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Q86VL8

- S47A2_HUMAN

UniProt

Q86VL8 - S47A2_HUMAN

Protein

Multidrug and toxin extrusion protein 2

Gene

SLC47A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.3 Publications

    Kineticsi

    1. KM=0.76 mM for TEA2 Publications
    2. KM=0.11 mM for MPP2 Publications
    3. KM=0.12 mM for cimetidine2 Publications
    4. KM=1.98 mM for metformin2 Publications
    5. KM=4.2 mM for guanidine2 Publications
    6. KM=1.58 mM for procainamide2 Publications
    7. KM=0.06 mM for topotecan2 Publications
    8. KM=0.85 mM for estrone sulfate2 Publications
    9. KM=4.32 mM for acyclovir2 Publications
    10. KM=4.28 mM for ganciclovir2 Publications

    Vmax=0.88 nmol/min/mg enzyme toward TEA2 Publications

    Vmax=0.575 nmol/min/mg enzyme toward MPP2 Publications

    Vmax=0.115 nmol/min/mg enzyme toward cimetidine2 Publications

    Vmax=0.845 nmol/min/mg enzyme toward metformin2 Publications

    Vmax=0.58 nmol/min/mg enzyme toward guanidine2 Publications

    Vmax=3.385 nmol/min/mg enzyme toward procainamide2 Publications

    Vmax=0.13 nmol/min/mg enzyme toward topotecan2 Publications

    Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate2 Publications

    Vmax=0.945 nmol/min/mg enzyme toward acyclovir2 Publications

    Vmax=0.805 nmol/min/mg enzyme toward ganciclovir2 Publications

    pH dependencei

    Optimum pH is 9.0. Active from pH 6 to 9.2 Publications

    GO - Molecular functioni

    1. antiporter activity Source: InterPro
    2. drug transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Protein family/group databases

    TCDBi2.A.66.1.20. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug and toxin extrusion protein 2
    Short name:
    MATE-2
    Short name:
    hMATE-2
    Alternative name(s):
    Kidney-specific H(+)/organic cation antiporter
    Solute carrier family 47 member 2
    Gene namesi
    Name:SLC47A2
    Synonyms:MATE2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:26439. SLC47A2.

    Subcellular locationi

    Cell membrane Curated; Multi-pass membrane protein Curated
    Note: Localized at the brush border membranes of the proximal tubules.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162403847.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602Multidrug and toxin extrusion protein 2PRO_0000311952Add
    BLAST

    Proteomic databases

    PaxDbiQ86VL8.
    PRIDEiQ86VL8.

    PTM databases

    PhosphoSiteiQ86VL8.

    Expressioni

    Tissue specificityi

    Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ86VL8.
    BgeeiQ86VL8.
    CleanExiHS_SLC47A2.
    GenevestigatoriQ86VL8.

    Organism-specific databases

    HPAiHPA044412.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4723030.
    STRINGi9606.ENSP00000326671.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VL8.
    SMRiQ86VL8. Positions 19-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 6612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini88 – 11932CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini141 – 15313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini175 – 21945CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini241 – 2488ExtracellularSequence Analysis
    Topological domaini270 – 28920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini310 – 32718ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini349 – 36820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini390 – 40213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini424 – 44219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini464 – 4663ExtracellularSequence Analysis
    Topological domaini488 – 57891CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini600 – 6023ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei220 – 24021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 30920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei443 – 46321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei579 – 59921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi508 – 5114Poly-Gln

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000060313.
    HOVERGENiHBG056043.
    InParanoidiQ86VL8.
    KOiK03327.
    OMAiCEPTKVT.
    OrthoDBiEOG7RRF71.
    PhylomeDBiQ86VL8.
    TreeFamiTF324441.

    Family and domain databases

    InterProiIPR002528. MATE.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86VL8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM    50
    IYIVSTVFCG HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF 100
    GSPNKKHVGV ILQRGALVLL LCCLPCWALF LNTQHILLLF RQDPDVSRLT 150
    QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL KGQEEESPFQ TPGLSILHPS 200
    HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV LNLGVRGSAY 250
    ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML 300
    MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV 350
    RVGMALGAAD TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND 400
    EDVIALVSQV LPVYSVFHVF EAICCVYGGV LRGTGKQAFG AAVNAITYYI 450
    IGLPLGILLT FVVRMRIMGL WLGMLACVFL ATAAFVAYTA RLDWKLAAEE 500
    AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL TTYSRSECHV 550
    DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT 600
    RH 602
    Length:602
    Mass (Da):65,085
    Last modified:June 1, 2003 - v1
    Checksum:i88EB90286AE701D1
    GO
    Isoform 2 (identifier: Q86VL8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-49: Missing.
         178-213: Missing.
         376-381: VGISLV → EMSLPW
         382-602: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:296
    Mass (Da):32,120
    Checksum:iA8233F83A55432EC
    GO
    Isoform 3 (identifier: Q86VL8-3) [UniParc]FASTAAdd to Basket

    Also known as: MATE2-K

    The sequence of this isoform differs from the canonical sequence as follows:
         178-213: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:566
    Mass (Da):61,016
    Checksum:iA3D0B0E578E0B8C2
    GO
    Isoform 4 (identifier: Q86VL8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         178-213: Missing.
         339-339: M → MRHSHRLAYAAHVTR

    Note: No experimental confirmation available.

    Show »
    Length:580
    Mass (Da):62,673
    Checksum:i848F216F93C7F1C7
    GO
    Isoform 5 (identifier: Q86VL8-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         178-213: Missing.
         317-398: GLLSVVDLSA...LKNQLGHIFT → EHAQCGGSLC...EKSAGAYFYQ
         399-602: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:362
    Mass (Da):39,287
    Checksum:i35A2CE7A78E3E19D
    GO
    Isoform 6 (identifier: Q86VL8-6) [UniParc]FASTAAdd to Basket

    Also known as: MATE2-B

    The sequence of this isoform differs from the canonical sequence as follows:
         178-219: GWLKGQEEES...HLFQKITWPQ → AGERLCVPAS...VHPPSISLTP
         220-602: Missing.

    Note: Inactive. Note=No experimental confirmation available.

    Show »
    Length:219
    Mass (Da):23,344
    Checksum:i40D6F1AA297DAA91
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61D → E in BAF37007. (PubMed:16807400)Curated
    Sequence conflicti23 – 231V → A in AK055758. (PubMed:14702039)Curated
    Sequence conflicti93 – 931D → G in AK055758. (PubMed:14702039)Curated
    Sequence conflicti284 – 2841C → Y in CAH56154. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti429 – 4291G → R.
    Corresponds to variant rs34399035 [ dbSNP | Ensembl ].
    VAR_037358

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_029656Add
    BLAST
    Alternative sequencei178 – 21942GWLKG…ITWPQ → AGERLCVPASSNSSTGMAEG AGGGVPIPNPGFVHPPSISL TP in isoform 6. 1 PublicationVSP_029657Add
    BLAST
    Alternative sequencei178 – 21336Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 4 PublicationsVSP_029658Add
    BLAST
    Alternative sequencei220 – 602383Missing in isoform 6. 1 PublicationVSP_029659Add
    BLAST
    Alternative sequencei317 – 39882GLLSV…GHIFT → EHAQCGGSLCPGCHLGGHCD LHDSLGAQHRGLCPSGDGSG GRGYCAGQALGRLGRAQHSW HFPGPGHPDKHPEKSAGAYF YQ in isoform 5. 1 PublicationVSP_029660Add
    BLAST
    Alternative sequencei339 – 3391M → MRHSHRLAYAAHVTR in isoform 4. 1 PublicationVSP_029662
    Alternative sequencei376 – 3816VGISLV → EMSLPW in isoform 2. 1 PublicationVSP_029663
    Alternative sequencei382 – 602221Missing in isoform 2. 1 PublicationVSP_029664Add
    BLAST
    Alternative sequencei399 – 602204Missing in isoform 5. 1 PublicationVSP_029661Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB250364 mRNA. Translation: BAF36847.1.
    AB250701 mRNA. Translation: BAF37007.1.
    AK055758 mRNA. No translation available.
    BX648861 mRNA. Translation: CAH56154.1.
    CH471212 Genomic DNA. Translation: EAW50902.1.
    CH471212 Genomic DNA. Translation: EAW50904.1.
    CH471212 Genomic DNA. Translation: EAW50905.1.
    BC035288 mRNA. Translation: AAH35288.1.
    BC050578 mRNA. Translation: AAH50578.1.
    CCDSiCCDS11211.1. [Q86VL8-1]
    CCDS58530.1. [Q86VL8-4]
    RefSeqiNP_001093116.1. NM_001099646.1. [Q86VL8-3]
    NP_001243592.1. NM_001256663.1. [Q86VL8-4]
    NP_690872.2. NM_152908.3. [Q86VL8-1]
    UniGeneiHs.126830.

    Genome annotation databases

    EnsembliENST00000325411; ENSP00000326671; ENSG00000180638. [Q86VL8-1]
    ENST00000350657; ENSP00000338084; ENSG00000180638. [Q86VL8-4]
    ENST00000574239; ENSP00000458694; ENSG00000180638. [Q86VL8-6]
    GeneIDi146802.
    KEGGihsa:146802.
    UCSCiuc002gwe.4. human. [Q86VL8-1]
    uc002gwf.4. human. [Q86VL8-4]
    uc002gwg.4. human. [Q86VL8-3]

    Polymorphism databases

    DMDMi74727585.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB250364 mRNA. Translation: BAF36847.1 .
    AB250701 mRNA. Translation: BAF37007.1 .
    AK055758 mRNA. No translation available.
    BX648861 mRNA. Translation: CAH56154.1 .
    CH471212 Genomic DNA. Translation: EAW50902.1 .
    CH471212 Genomic DNA. Translation: EAW50904.1 .
    CH471212 Genomic DNA. Translation: EAW50905.1 .
    BC035288 mRNA. Translation: AAH35288.1 .
    BC050578 mRNA. Translation: AAH50578.1 .
    CCDSi CCDS11211.1. [Q86VL8-1 ]
    CCDS58530.1. [Q86VL8-4 ]
    RefSeqi NP_001093116.1. NM_001099646.1. [Q86VL8-3 ]
    NP_001243592.1. NM_001256663.1. [Q86VL8-4 ]
    NP_690872.2. NM_152908.3. [Q86VL8-1 ]
    UniGenei Hs.126830.

    3D structure databases

    ProteinModelPortali Q86VL8.
    SMRi Q86VL8. Positions 19-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4723030.
    STRINGi 9606.ENSP00000326671.

    Chemistry

    ChEMBLi CHEMBL1743127.
    GuidetoPHARMACOLOGYi 1217.

    Protein family/group databases

    TCDBi 2.A.66.1.20. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

    PTM databases

    PhosphoSitei Q86VL8.

    Polymorphism databases

    DMDMi 74727585.

    Proteomic databases

    PaxDbi Q86VL8.
    PRIDEi Q86VL8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325411 ; ENSP00000326671 ; ENSG00000180638 . [Q86VL8-1 ]
    ENST00000350657 ; ENSP00000338084 ; ENSG00000180638 . [Q86VL8-4 ]
    ENST00000574239 ; ENSP00000458694 ; ENSG00000180638 . [Q86VL8-6 ]
    GeneIDi 146802.
    KEGGi hsa:146802.
    UCSCi uc002gwe.4. human. [Q86VL8-1 ]
    uc002gwf.4. human. [Q86VL8-4 ]
    uc002gwg.4. human. [Q86VL8-3 ]

    Organism-specific databases

    CTDi 146802.
    GeneCardsi GC17M019582.
    H-InvDB HIX0039367.
    HGNCi HGNC:26439. SLC47A2.
    HPAi HPA044412.
    MIMi 609833. gene.
    neXtProti NX_Q86VL8.
    PharmGKBi PA162403847.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000060313.
    HOVERGENi HBG056043.
    InParanoidi Q86VL8.
    KOi K03327.
    OMAi CEPTKVT.
    OrthoDBi EOG7RRF71.
    PhylomeDBi Q86VL8.
    TreeFami TF324441.

    Enzyme and pathway databases

    Reactomei REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Miscellaneous databases

    GeneWikii SLC47A2.
    GenomeRNAii 146802.
    NextBioi 85455.
    PROi Q86VL8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86VL8.
    Bgeei Q86VL8.
    CleanExi HS_SLC47A2.
    Genevestigatori Q86VL8.

    Family and domain databases

    InterProi IPR002528. MATE.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2."
      Masuda S., Terada T., Yonezawa A., Tanihara Y., Kishimoto K., Katsura T., Ogawa O., Inui K.
      J. Am. Soc. Nephrol. 17:2127-2135(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 6), TISSUE SPECIFICITY, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
      Tissue: Brain and Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Small intestine.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Colon.
    6. "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations."
      Omote H., Hiasa M., Matsumoto T., Otsuka M., Moriyama Y.
      Trends Pharmacol. Sci. 27:587-593(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters."
      Tanihara Y., Masuda S., Sato T., Katsura T., Ogawa O., Inui K.
      Biochem. Pharmacol. 74:359-371(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

    Entry informationi

    Entry nameiS47A2_HUMAN
    AccessioniPrimary (citable) accession number: Q86VL8
    Secondary accession number(s): A0JBX9
    , A0P8Z7, Q63HJ9, Q8IV44, Q96NA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3