Q86VL8 (S47A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Multidrug and toxin extrusion protein 2
Short name=MATE-2
Short name=hMATE-2

Alternative name(s):
Kidney-specific H(+)/organic cation antiporter
Solute carrier family 47 member 2

Gene names

Name:	SLC47A2
Synonyms:	MATE2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	602 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. Ref.1 Ref.6 Ref.7
Subcellular location	Cell membrane; Multi-pass membrane protein Potential. Note: Localized at the brush border membranes of the proximal tubules.
Tissue specificity	Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain. Ref.1
Sequence similarities	Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. [View classification]
Biophysicochemical properties	Kinetic parameters: KM=0.76 mM for TEA Ref.1 Ref.7 KM=0.11 mM for MPP KM=0.12 mM for cimetidine KM=1.98 mM for metformin KM=4.2 mM for guanidine KM=1.58 mM for procainamide KM=0.06 mM for topotecan KM=0.85 mM for estrone sulfate KM=4.32 mM for acyclovir KM=4.28 mM for ganciclovir Vmax=0.88 nmol/min/mg enzyme toward TEA Vmax=0.575 nmol/min/mg enzyme toward MPP Vmax=0.115 nmol/min/mg enzyme toward cimetidine Vmax=0.845 nmol/min/mg enzyme toward metformin Vmax=0.58 nmol/min/mg enzyme toward guanidine Vmax=3.385 nmol/min/mg enzyme toward procainamide Vmax=0.13 nmol/min/mg enzyme toward topotecan Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate Vmax=0.945 nmol/min/mg enzyme toward acyclovir Vmax=0.805 nmol/min/mg enzyme toward ganciclovir pH dependence: Optimum pH is 9.0. Active from pH 6 to 9.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antiporter activity Inferred from electronic annotation. Source: InterPro drug transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VL8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VL8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
     178-213: Missing.
     376-381: VGISLV → EMSLPW
     382-602: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q86VL8-3)

Also known as: MATE2-K;

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q86VL8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: Missing.
     339-339: M → MRHSHRLAYAAHVTR

Note: No experimental confirmation available.

Isoform 5 (identifier: Q86VL8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: Missing.
     317-398: GLLSVVDLSA...LKNQLGHIFT → EHAQCGGSLC...EKSAGAYFYQ
     399-602: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q86VL8-6)

Also known as: MATE2-B;

The sequence of this isoform differs from the canonical sequence as follows:
     178-219: GWLKGQEEES...HLFQKITWPQ → AGERLCVPAS...VHPPSISLTP
     220-602: Missing.

Note: Inactive. Note=No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 602	602	Multidrug and toxin extrusion protein 2		PRO_0000311952
Regions
	Topological domain	1 – 33	33	Cytoplasmic Potential
	Transmembrane	34 – 54	21	Helical; Potential
	Topological domain	55 – 66	12	Extracellular Potential
	Transmembrane	67 – 87	21	Helical; Potential
	Topological domain	88 – 119	32	Cytoplasmic Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Topological domain	141 – 153	13	Extracellular Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Topological domain	175 – 219	45	Cytoplasmic Potential
	Transmembrane	220 – 240	21	Helical; Potential
	Topological domain	241 – 248	8	Extracellular Potential
	Transmembrane	249 – 269	21	Helical; Potential
	Topological domain	270 – 289	20	Cytoplasmic Potential
	Transmembrane	290 – 309	20	Helical; Potential
	Topological domain	310 – 327	18	Extracellular Potential
	Transmembrane	328 – 348	21	Helical; Potential
	Topological domain	349 – 368	20	Cytoplasmic Potential
	Transmembrane	369 – 389	21	Helical; Potential
	Topological domain	390 – 402	13	Extracellular Potential
	Transmembrane	403 – 423	21	Helical; Potential
	Topological domain	424 – 442	19	Cytoplasmic Potential
	Transmembrane	443 – 463	21	Helical; Potential
	Topological domain	464 – 466	3	Extracellular Potential
	Transmembrane	467 – 487	21	Helical; Potential
	Topological domain	488 – 578	91	Cytoplasmic Potential
	Transmembrane	579 – 599	21	Helical; Potential
	Topological domain	600 – 602	3	Extracellular Potential
	Compositional bias	508 – 511	4	Poly-Gln
Natural variations
	Alternative sequence	1 – 49	49	Missing in isoform 2.		VSP_029656
	Alternative sequence	178 – 219	42	GWLKG…ITWPQ → AGERLCVPASSNSSTGMAEG AGGGVPIPNPGFVHPPSISL TP in isoform 6.		VSP_029657
	Alternative sequence	178 – 213	36	Missing in isoform 2, isoform 3, isoform 4 and isoform 5.		VSP_029658
	Alternative sequence	220 – 602	383	Missing in isoform 6.		VSP_029659
	Alternative sequence	317 – 398	82	GLLSV…GHIFT → EHAQCGGSLCPGCHLGGHCD LHDSLGAQHRGLCPSGDGSG GRGYCAGQALGRLGRAQHSW HFPGPGHPDKHPEKSAGAYF YQ in isoform 5.		VSP_029660
	Alternative sequence	339	1	M → MRHSHRLAYAAHVTR in isoform 4.		VSP_029662
	Alternative sequence	376 – 381	6	VGISLV → EMSLPW in isoform 2.		VSP_029663
	Alternative sequence	382 – 602	221	Missing in isoform 2.		VSP_029664
	Alternative sequence	399 – 602	204	Missing in isoform 5.		VSP_029661
	Natural variant	429	1	G → R. Corresponds to variant rs34399035 [ dbSNP | Ensembl ].		VAR_037358
Experimental info
	Sequence conflict	6	1	D → E in BAF37007. Ref.1
	Sequence conflict	23	1	V → A in AK055758. Ref.2
	Sequence conflict	93	1	D → G in AK055758. Ref.2
	Sequence conflict	284	1	C → Y in CAH56154. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 88EB90286AE701D1	FASTA	602	65,085
	10 20 30 40 50 60 MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG 70 80 90 100 110 120 HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL 130 140 150 160 170 180 LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL 190 200 210 220 230 240 KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV 250 260 270 280 290 300 LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML 310 320 330 340 350 360 MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD 370 380 390 400 410 420 TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF 430 440 450 460 470 480 EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL 490 500 510 520 530 540 ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL 550 560 570 580 590 600 TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT RH
	Isoform 2 [UniParc]. Checksum: A8233F83A55432EC	FASTA	296	32,120
	10 20 30 40 50 60 MIYIVSTVFC GHLGKVELAS VTLAVAFVNV CGVSVGVGLS SACDTLMSQS FGSPNKKHVG 70 80 90 100 110 120 VILQRGALVL LLCCLPCWAL FLNTQHILLL FRQDPDVSRL TQDYVMIFIP GLPVIFLYNL 130 140 150 160 170 180 LAKYLQNQKI TWPQVLSGVV GNCVNGVANY ALVSVLNLGV RGSAYANIIS QFAQTVFLLL 190 200 210 220 230 240 YIVLKKLHLE TWAGWSSQCL QDWGPFFSLA VPSMLMICVE WWAYEIGSFL MGLLSVVDLS 250 260 270 280 290 AQAVIYEVAT VTYMIPLGLS IGVCVRVGMA LGAADTVQAK RSAVSGVLSI EMSLPW
	Isoform 3 (MATE2-K) [UniParc]. Checksum: A3D0B0E578E0B8C2	FASTA	566	61,016
	10 20 30 40 50 60 MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG 70 80 90 100 110 120 HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL 130 140 150 160 170 180 LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQKIT 190 200 210 220 230 240 WPQVLSGVVG NCVNGVANYA LVSVLNLGVR GSAYANIISQ FAQTVFLLLY IVLKKLHLET 250 260 270 280 290 300 WAGWSSQCLQ DWGPFFSLAV PSMLMICVEW WAYEIGSFLM GLLSVVDLSA QAVIYEVATV 310 320 330 340 350 360 TYMIPLGLSI GVCVRVGMAL GAADTVQAKR SAVSGVLSIV GISLVLGTLI SILKNQLGHI 370 380 390 400 410 420 FTNDEDVIAL VSQVLPVYSV FHVFEAICCV YGGVLRGTGK QAFGAAVNAI TYYIIGLPLG 430 440 450 460 470 480 ILLTFVVRMR IMGLWLGMLA CVFLATAAFV AYTARLDWKL AAEEAKKHSG RQQQQRAEST 490 500 510 520 530 540 ATRPGPEKAV LSSVATGSSP GITLTTYSRS ECHVDFFRTP EEAHALSAPT SRLSVKQLVI 550 560 RRGAALGAAS ATLMVGLTVR ILATRH
	Isoform 4 [UniParc]. Checksum: 848F216F93C7F1C7	FASTA	580	62,673
	10 20 30 40 50 60 MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG 70 80 90 100 110 120 HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL 130 140 150 160 170 180 LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQKIT 190 200 210 220 230 240 WPQVLSGVVG NCVNGVANYA LVSVLNLGVR GSAYANIISQ FAQTVFLLLY IVLKKLHLET 250 260 270 280 290 300 WAGWSSQCLQ DWGPFFSLAV PSMLMICVEW WAYEIGSFLM GLLSVVDLSA QAVIYEVATV 310 320 330 340 350 360 TYMRHSHRLA YAAHVTRIPL GLSIGVCVRV GMALGAADTV QAKRSAVSGV LSIVGISLVL 370 380 390 400 410 420 GTLISILKNQ LGHIFTNDED VIALVSQVLP VYSVFHVFEA ICCVYGGVLR GTGKQAFGAA 430 440 450 460 470 480 VNAITYYIIG LPLGILLTFV VRMRIMGLWL GMLACVFLAT AAFVAYTARL DWKLAAEEAK 490 500 510 520 530 540 KHSGRQQQQR AESTATRPGP EKAVLSSVAT GSSPGITLTT YSRSECHVDF FRTPEEAHAL 550 560 570 580 SAPTSRLSVK QLVIRRGAAL GAASATLMVG LTVRILATRH
	Isoform 5 [UniParc]. Checksum: 35A2CE7A78E3E19D	FASTA	362	39,287
	10 20 30 40 50 60 MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG 70 80 90 100 110 120 HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL 130 140 150 160 170 180 LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQKIT 190 200 210 220 230 240 WPQVLSGVVG NCVNGVANYA LVSVLNLGVR GSAYANIISQ FAQTVFLLLY IVLKKLHLET 250 260 270 280 290 300 WAGWSSQCLQ DWGPFFSLAV PSMLMICVEW WAYEIGSFLM EHAQCGGSLC PGCHLGGHCD 310 320 330 340 350 360 LHDSLGAQHR GLCPSGDGSG GRGYCAGQAL GRLGRAQHSW HFPGPGHPDK HPEKSAGAYF YQ
	Isoform 6 (MATE2-B) [UniParc]. Checksum: 40D6F1AA297DAA91	FASTA	219	23,344
	10 20 30 40 50 60 MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG 70 80 90 100 110 120 HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL 130 140 150 160 170 180 LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQAGE 190 200 210 RLCVPASSNS STGMAEGAGG GVPIPNPGFV HPPSISLTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2." Masuda S., Terada T., Yonezawa A., Tanihara Y., Kishimoto K., Katsura T., Ogawa O., Inui K. J. Am. Soc. Nephrol. 17:2127-2135(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 6), TISSUE SPECIFICITY, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES. Tissue: Brain and Kidney.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Kidney.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Small intestine.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Colon.
[6]	"The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations." Omote H., Hiasa M., Matsumoto T., Otsuka M., Moriyama Y. Trends Pharmacol. Sci. 27:587-593(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters." Tanihara Y., Masuda S., Sato T., Katsura T., Ogawa O., Inui K. Biochem. Pharmacol. 74:359-371(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB250364 mRNA. Translation: BAF36847.1. AB250701 mRNA. Translation: BAF37007.1. AK055758 mRNA. No translation available. BX648861 mRNA. Translation: CAH56154.1. CH471212 Genomic DNA. Translation: EAW50902.1. CH471212 Genomic DNA. Translation: EAW50904.1. CH471212 Genomic DNA. Translation: EAW50905.1. BC035288 mRNA. Translation: AAH35288.1. BC050578 mRNA. Translation: AAH50578.1.
IPI	IPI00383387. IPI00384332. IPI00793287. IPI00796514. IPI00876926. IPI00876983.
RefSeq	NP_001093116.1. NM_001099646.1. NP_001243592.1. NM_001256663.1. NP_690872.2. NM_152908.3.
UniGene	Hs.126830.
3D structure databases
ProteinModelPortal	Q86VL8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000326671.
Protein family/group databases
TCDB	2.A.66.1.17. multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) flippase superfamily. 2.A.66.1.20. multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) flippase superfamily.
PTM databases
PhosphoSite	Q86VL8.
Polymorphism databases
DMDM	74727585.
Proteomic databases
PaxDb	Q86VL8.
PRIDE	Q86VL8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325411; ENSP00000326671; ENSG00000180638. ENST00000350657; ENSP00000338084; ENSG00000180638. ENST00000574239; ENSP00000458694; ENSG00000180638.
GeneID	146802.
KEGG	hsa:146802.
UCSC	uc002gwe.4. human. uc002gwf.4. human. uc002gwg.4. human.
Organism-specific databases
CTD	146802.
GeneCards	GC17M019582.
H-InvDB	HIX0039367.
HGNC	HGNC:26439. SLC47A2.
HPA	HPA044412.
MIM	609833. gene.
neXtProt	NX_Q86VL8.
PharmGKB	PA162403847.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0534.
HOGENOM	HOG000060313.
HOVERGEN	HBG056043.
InParanoid	Q86VL8.
KO	K03327.
OMA	QGFWLAF.
PhylomeDB	Q86VL8.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_20633. Bile salt and organic anion SLC transporters.
Gene expression databases
ArrayExpress	Q86VL8.
Bgee	Q86VL8.
CleanEx	HS_SLC47A2.
Genevestigator	Q86VL8.
Family and domain databases
InterPro	IPR002528. MATE. [Graphical view]
Pfam	PF01554. MatE. 2 hits. [Graphical view]
TIGRFAMs	TIGR00797. matE. 1 hit.
ProtoNet	Search...
Other
ChEMBL	CHEMBL1743127.
GenomeRNAi	146802.
NextBio	85455.
SOURCE	Search...

Entry information

Entry name

S47A2_HUMAN

Accession

Primary (citable) accession number: Q86VL8
Secondary accession number(s): A0JBX9 , A0P8Z7, Q63HJ9, Q8IV44, Q96NA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.