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Protein

Multidrug and toxin extrusion protein 2

Gene

SLC47A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.3 Publications

Kineticsi

  1. KM=0.76 mM for TEA2 Publications
  2. KM=0.11 mM for MPP2 Publications
  3. KM=0.12 mM for cimetidine2 Publications
  4. KM=1.98 mM for metformin2 Publications
  5. KM=4.2 mM for guanidine2 Publications
  6. KM=1.58 mM for procainamide2 Publications
  7. KM=0.06 mM for topotecan2 Publications
  8. KM=0.85 mM for estrone sulfate2 Publications
  9. KM=4.32 mM for acyclovir2 Publications
  10. KM=4.28 mM for ganciclovir2 Publications
  1. Vmax=0.88 nmol/min/mg enzyme toward TEA2 Publications
  2. Vmax=0.575 nmol/min/mg enzyme toward MPP2 Publications
  3. Vmax=0.115 nmol/min/mg enzyme toward cimetidine2 Publications
  4. Vmax=0.845 nmol/min/mg enzyme toward metformin2 Publications
  5. Vmax=0.58 nmol/min/mg enzyme toward guanidine2 Publications
  6. Vmax=3.385 nmol/min/mg enzyme toward procainamide2 Publications
  7. Vmax=0.13 nmol/min/mg enzyme toward topotecan2 Publications
  8. Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate2 Publications
  9. Vmax=0.945 nmol/min/mg enzyme toward acyclovir2 Publications
  10. Vmax=0.805 nmol/min/mg enzyme toward ganciclovir2 Publications

pH dependencei

Optimum pH is 9.0. Active from pH 6 to 9.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.66.1.20. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 2
Short name:
MATE-2
Short name:
hMATE-2
Alternative name(s):
Kidney-specific H(+)/organic cation antiporter
Solute carrier family 47 member 2
Gene namesi
Name:SLC47A2
Synonyms:MATE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26439. SLC47A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Topological domaini55 – 6612ExtracellularSequence AnalysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Topological domaini88 – 11932CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Topological domaini141 – 15313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Topological domaini175 – 21945CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence AnalysisAdd
BLAST
Topological domaini241 – 2488ExtracellularSequence Analysis
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Topological domaini270 – 28920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei290 – 30920HelicalSequence AnalysisAdd
BLAST
Topological domaini310 – 32718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence AnalysisAdd
BLAST
Topological domaini349 – 36820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei369 – 38921HelicalSequence AnalysisAdd
BLAST
Topological domaini390 – 40213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence AnalysisAdd
BLAST
Topological domaini424 – 44219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei443 – 46321HelicalSequence AnalysisAdd
BLAST
Topological domaini464 – 4663ExtracellularSequence Analysis
Transmembranei467 – 48721HelicalSequence AnalysisAdd
BLAST
Topological domaini488 – 57891CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei579 – 59921HelicalSequence AnalysisAdd
BLAST
Topological domaini600 – 6023ExtracellularSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403847.

Chemistry

DrugBankiDB00787. Aciclovir.

Polymorphism and mutation databases

BioMutaiSLC47A2.
DMDMi74727585.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Multidrug and toxin extrusion protein 2PRO_0000311952Add
BLAST

Proteomic databases

PaxDbiQ86VL8.
PRIDEiQ86VL8.

PTM databases

PhosphoSiteiQ86VL8.

Expressioni

Tissue specificityi

Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.1 Publication

Gene expression databases

BgeeiQ86VL8.
CleanExiHS_SLC47A2.
ExpressionAtlasiQ86VL8. baseline and differential.
GenevisibleiQ86VL8. HS.

Organism-specific databases

HPAiHPA062112.

Interactioni

Protein-protein interaction databases

MINTiMINT-4723030.
STRINGi9606.ENSP00000326671.

Structurei

3D structure databases

ProteinModelPortaliQ86VL8.
SMRiQ86VL8. Positions 19-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi508 – 5114Poly-Gln

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
GeneTreeiENSGT00390000015713.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiQ86VL8.
KOiK03327.
OMAiKISHHHI.
OrthoDBiEOG7RRF71.
PhylomeDBiQ86VL8.
TreeFamiTF324441.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM
60 70 80 90 100
IYIVSTVFCG HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF
110 120 130 140 150
GSPNKKHVGV ILQRGALVLL LCCLPCWALF LNTQHILLLF RQDPDVSRLT
160 170 180 190 200
QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL KGQEEESPFQ TPGLSILHPS
210 220 230 240 250
HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV LNLGVRGSAY
260 270 280 290 300
ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML
310 320 330 340 350
MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV
360 370 380 390 400
RVGMALGAAD TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND
410 420 430 440 450
EDVIALVSQV LPVYSVFHVF EAICCVYGGV LRGTGKQAFG AAVNAITYYI
460 470 480 490 500
IGLPLGILLT FVVRMRIMGL WLGMLACVFL ATAAFVAYTA RLDWKLAAEE
510 520 530 540 550
AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL TTYSRSECHV
560 570 580 590 600
DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT

RH
Length:602
Mass (Da):65,085
Last modified:June 1, 2003 - v1
Checksum:i88EB90286AE701D1
GO
Isoform 2 (identifier: Q86VL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
     178-213: Missing.
     376-381: VGISLV → EMSLPW
     382-602: Missing.

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):32,120
Checksum:iA8233F83A55432EC
GO
Isoform 3 (identifier: Q86VL8-3) [UniParc]FASTAAdd to basket

Also known as: MATE2-K

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: Missing.

Note: No experimental confirmation available.
Show »
Length:566
Mass (Da):61,016
Checksum:iA3D0B0E578E0B8C2
GO
Isoform 4 (identifier: Q86VL8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: Missing.
     339-339: M → MRHSHRLAYAAHVTR

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):62,673
Checksum:i848F216F93C7F1C7
GO
Isoform 5 (identifier: Q86VL8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: Missing.
     317-398: GLLSVVDLSA...LKNQLGHIFT → EHAQCGGSLC...EKSAGAYFYQ
     399-602: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):39,287
Checksum:i35A2CE7A78E3E19D
GO
Isoform 6 (identifier: Q86VL8-6) [UniParc]FASTAAdd to basket

Also known as: MATE2-B

The sequence of this isoform differs from the canonical sequence as follows:
     178-219: GWLKGQEEES...HLFQKITWPQ → AGERLCVPAS...VHPPSISLTP
     220-602: Missing.

Note: Inactive. Note=No experimental confirmation available.
Show »
Length:219
Mass (Da):23,344
Checksum:i40D6F1AA297DAA91
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61D → E in BAF37007 (PubMed:16807400).Curated
Sequence conflicti23 – 231V → A in AK055758 (PubMed:14702039).Curated
Sequence conflicti93 – 931D → G in AK055758 (PubMed:14702039).Curated
Sequence conflicti284 – 2841C → Y in CAH56154 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti429 – 4291G → R.
Corresponds to variant rs34399035 [ dbSNP | Ensembl ].
VAR_037358

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_029656Add
BLAST
Alternative sequencei178 – 21942GWLKG…ITWPQ → AGERLCVPASSNSSTGMAEG AGGGVPIPNPGFVHPPSISL TP in isoform 6. 1 PublicationVSP_029657Add
BLAST
Alternative sequencei178 – 21336Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 4 PublicationsVSP_029658Add
BLAST
Alternative sequencei220 – 602383Missing in isoform 6. 1 PublicationVSP_029659Add
BLAST
Alternative sequencei317 – 39882GLLSV…GHIFT → EHAQCGGSLCPGCHLGGHCD LHDSLGAQHRGLCPSGDGSG GRGYCAGQALGRLGRAQHSW HFPGPGHPDKHPEKSAGAYF YQ in isoform 5. 1 PublicationVSP_029660Add
BLAST
Alternative sequencei339 – 3391M → MRHSHRLAYAAHVTR in isoform 4. 1 PublicationVSP_029662
Alternative sequencei376 – 3816VGISLV → EMSLPW in isoform 2. 1 PublicationVSP_029663
Alternative sequencei382 – 602221Missing in isoform 2. 1 PublicationVSP_029664Add
BLAST
Alternative sequencei399 – 602204Missing in isoform 5. 1 PublicationVSP_029661Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB250364 mRNA. Translation: BAF36847.1.
AB250701 mRNA. Translation: BAF37007.1.
AK055758 mRNA. No translation available.
BX648861 mRNA. Translation: CAH56154.1.
CH471212 Genomic DNA. Translation: EAW50902.1.
CH471212 Genomic DNA. Translation: EAW50904.1.
CH471212 Genomic DNA. Translation: EAW50905.1.
BC035288 mRNA. Translation: AAH35288.1.
BC050578 mRNA. Translation: AAH50578.1.
CCDSiCCDS11211.1. [Q86VL8-1]
CCDS58530.1. [Q86VL8-4]
RefSeqiNP_001093116.1. NM_001099646.1. [Q86VL8-3]
NP_001243592.1. NM_001256663.1. [Q86VL8-4]
NP_690872.2. NM_152908.3. [Q86VL8-1]
UniGeneiHs.126830.

Genome annotation databases

EnsembliENST00000325411; ENSP00000326671; ENSG00000180638.
ENST00000350657; ENSP00000338084; ENSG00000180638. [Q86VL8-4]
ENST00000574239; ENSP00000458694; ENSG00000180638. [Q86VL8-6]
GeneIDi146802.
KEGGihsa:146802.
UCSCiuc002gwe.4. human. [Q86VL8-1]
uc002gwf.4. human. [Q86VL8-4]
uc002gwg.4. human. [Q86VL8-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB250364 mRNA. Translation: BAF36847.1.
AB250701 mRNA. Translation: BAF37007.1.
AK055758 mRNA. No translation available.
BX648861 mRNA. Translation: CAH56154.1.
CH471212 Genomic DNA. Translation: EAW50902.1.
CH471212 Genomic DNA. Translation: EAW50904.1.
CH471212 Genomic DNA. Translation: EAW50905.1.
BC035288 mRNA. Translation: AAH35288.1.
BC050578 mRNA. Translation: AAH50578.1.
CCDSiCCDS11211.1. [Q86VL8-1]
CCDS58530.1. [Q86VL8-4]
RefSeqiNP_001093116.1. NM_001099646.1. [Q86VL8-3]
NP_001243592.1. NM_001256663.1. [Q86VL8-4]
NP_690872.2. NM_152908.3. [Q86VL8-1]
UniGeneiHs.126830.

3D structure databases

ProteinModelPortaliQ86VL8.
SMRiQ86VL8. Positions 19-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4723030.
STRINGi9606.ENSP00000326671.

Chemistry

BindingDBiQ86VL8.
ChEMBLiCHEMBL1743127.
DrugBankiDB00787. Aciclovir.
GuidetoPHARMACOLOGYi1217.

Protein family/group databases

TCDBi2.A.66.1.20. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

PTM databases

PhosphoSiteiQ86VL8.

Polymorphism and mutation databases

BioMutaiSLC47A2.
DMDMi74727585.

Proteomic databases

PaxDbiQ86VL8.
PRIDEiQ86VL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325411; ENSP00000326671; ENSG00000180638.
ENST00000350657; ENSP00000338084; ENSG00000180638. [Q86VL8-4]
ENST00000574239; ENSP00000458694; ENSG00000180638. [Q86VL8-6]
GeneIDi146802.
KEGGihsa:146802.
UCSCiuc002gwe.4. human. [Q86VL8-1]
uc002gwf.4. human. [Q86VL8-4]
uc002gwg.4. human. [Q86VL8-3]

Organism-specific databases

CTDi146802.
GeneCardsiGC17M019582.
H-InvDBHIX0039367.
HGNCiHGNC:26439. SLC47A2.
HPAiHPA062112.
MIMi609833. gene.
neXtProtiNX_Q86VL8.
PharmGKBiPA162403847.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0534.
GeneTreeiENSGT00390000015713.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiQ86VL8.
KOiK03327.
OMAiKISHHHI.
OrthoDBiEOG7RRF71.
PhylomeDBiQ86VL8.
TreeFamiTF324441.

Enzyme and pathway databases

ReactomeiREACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

GeneWikiiSLC47A2.
GenomeRNAii146802.
NextBioi85455.
PROiQ86VL8.
SOURCEiSearch...

Gene expression databases

BgeeiQ86VL8.
CleanExiHS_SLC47A2.
ExpressionAtlasiQ86VL8. baseline and differential.
GenevisibleiQ86VL8. HS.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2."
    Masuda S., Terada T., Yonezawa A., Tanihara Y., Kishimoto K., Katsura T., Ogawa O., Inui K.
    J. Am. Soc. Nephrol. 17:2127-2135(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 6), TISSUE SPECIFICITY, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    Tissue: Brain and Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Colon.
  6. "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations."
    Omote H., Hiasa M., Matsumoto T., Otsuka M., Moriyama Y.
    Trends Pharmacol. Sci. 27:587-593(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters."
    Tanihara Y., Masuda S., Sato T., Katsura T., Ogawa O., Inui K.
    Biochem. Pharmacol. 74:359-371(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

Entry informationi

Entry nameiS47A2_HUMAN
AccessioniPrimary (citable) accession number: Q86VL8
Secondary accession number(s): A0JBX9
, A0P8Z7, Q63HJ9, Q8IV44, Q96NA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.