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Protein

Zinc finger protein 410

Gene

ZNF410

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 410
Alternative name(s):
Another partner for ARF 1
Zinc finger protein APA-1
Gene namesi
Name:ZNF410
Synonyms:APA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20144. ZNF410.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57862.
OpenTargetsiENSG00000119725.
PharmGKBiPA134958929.

Polymorphism and mutation databases

BioMutaiZNF410.
DMDMi37538029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475711 – 478Zinc finger protein 410Add BLAST478

Post-translational modificationi

Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ86VK4.
PaxDbiQ86VK4.
PeptideAtlasiQ86VK4.
PRIDEiQ86VK4.

PTM databases

iPTMnetiQ86VK4.
PhosphoSitePlusiQ86VK4.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

During fibroblast senescence.1 Publication

Gene expression databases

BgeeiENSG00000119725.
CleanExiHS_ZNF410.
ExpressionAtlasiQ86VK4. baseline and differential.
GenevisibleiQ86VK4. HS.

Organism-specific databases

HPAiHPA002871.

Interactioni

Subunit structurei

Interacts with CDKN2A/p14ARF.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BLZF1Q9H2G93EBI-720304,EBI-2548012
CEP70Q8NHQ13EBI-720304,EBI-739624
FAM9BQ8IZU03EBI-720304,EBI-10175124
FSD2A1L4K13EBI-720304,EBI-5661036
GOLGA2Q083793EBI-720304,EBI-618309
MTUS2Q5JR593EBI-720304,EBI-742948
RAB3IPQ96QF03EBI-720304,EBI-747844
SERTAD1Q53GC03EBI-720304,EBI-2826300
TRAF2Q129333EBI-720304,EBI-355744
TSGA10Q9BZW73EBI-720304,EBI-744794
ZNF397Q8NF993EBI-720304,EBI-10213894

Protein-protein interaction databases

BioGridi121792. 13 interactors.
IntActiQ86VK4. 32 interactors.
MINTiMINT-1425763.
STRINGi9606.ENSP00000407130.

Structurei

3D structure databases

ProteinModelPortaliQ86VK4.
SMRiQ86VK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000069877.
HOVERGENiHBG055280.
InParanoidiQ86VK4.
OMAiDDTPNHT.
OrthoDBiEOG091G06YO.
PhylomeDBiQ86VK4.
TreeFamiTF333498.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSDELESKP ELLVQFVQNT SIPLGQGLVE SEAKDITCLS LLPVTEASEC
60 70 80 90 100
SRLMLPDDTT NHSNSSKEVP SSAVLRSLRV NVGPDGEETR AQTVQKSPEF
110 120 130 140 150
LSTSESSSLL QDLQPSDSTS FILLNLTRAG LGSSAEHLVF VQDEAEDSGN
160 170 180 190 200
DFLSSESTDS SIPWFLRVQE LAHDSLIAAT RAQLAKNAKT SSNGENVHLG
210 220 230 240 250
SGDGQSKDSG PLPQVEKKLK CTVEGCDRTF VWPAHFKYHL KTHRNDRSFI
260 270 280 290 300
CPAEGCGKSF YVLQRLKVHM RTHNGEKPFM CHESGCGKQF TTAGNLKNHR
310 320 330 340 350
RIHTGEKPFL CEAQGCGRSF AEYSSLRKHL VVHSGEKPHQ CQVCGKTFSQ
360 370 380 390 400
SGSRNVHMRK HHLQLGAAGS QEQEQTAEPL MGSSLLEEAS VPSKNLVSMN
410 420 430 440 450
SQPSLGGESL NLPNTNSILG VDDEVLAEGS PRSLSSVPDV THHLVTMQSG
460 470
RQSYEVSVLT AVNPQELLNQ GDLTERRT
Length:478
Mass (Da):52,113
Last modified:October 3, 2003 - v2
Checksum:i1D7F7E139618F863
GO
Isoform 2 (identifier: Q86VK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-272: NDRSFICPAEGCGKSFYVLQRLKVHMRT → RLWEKLLCAAEAEGAHEDPQWREALYVP
     273-478: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:272
Mass (Da):29,761
Checksum:iB3A06732DA0C01F8
GO
Isoform 3 (identifier: Q86VK4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-423: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):47,318
Checksum:i92051EC28E38E1A4
GO
Isoform 4 (identifier: Q86VK4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-129: Missing.

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):44,254
Checksum:i99A1BF0D2CDCB18C
GO
Isoform 5 (identifier: Q86VK4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-57: D → EPVPWREEDGKSGCSDLN
     467-478: LLNQGDLTERRT → SLAPLPRLECSGAFSAHCNLCLPGSSDSPASAS

Note: No experimental confirmation available.
Show »
Length:516
Mass (Da):55,829
Checksum:i062D596402E5AAAA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04242457 – 129Missing in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_04341757D → EPVPWREEDGKSGCSDLN in isoform 5. 1 Publication1
Alternative sequenceiVSP_008485245 – 272NDRSF…VHMRT → RLWEKLLCAAEAEGAHEDPQ WREALYVP in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_008486273 – 478Missing in isoform 2. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_008487377 – 423Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_043418467 – 478LLNQG…TERRT → SLAPLPRLECSGAFSAHCNL CLPGSSDSPASAS in isoform 5. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90919 mRNA. Translation: AAB51059.1.
AK293350 mRNA. Translation: BAG56866.1.
AK299138 mRNA. Translation: BAG61190.1.
AC005480 Genomic DNA. No translation available.
AC005520 Genomic DNA. No translation available.
BC000330 mRNA. No translation available.
BC004357 mRNA. No translation available.
BC050683 mRNA. Translation: AAH50683.1.
CCDSiCCDS55929.1. [Q86VK4-5]
CCDS55930.1. [Q86VK4-3]
CCDS55931.1. [Q86VK4-4]
CCDS9821.1. [Q86VK4-1]
RefSeqiNP_001229853.1. NM_001242924.1. [Q86VK4-5]
NP_001229855.1. NM_001242926.1. [Q86VK4-3]
NP_001229856.1. NM_001242927.1. [Q86VK4-4]
NP_067011.1. NM_021188.2. [Q86VK4-1]
UniGeneiHs.270869.

Genome annotation databases

EnsembliENST00000324593; ENSP00000323293; ENSG00000119725. [Q86VK4-3]
ENST00000398139; ENSP00000381208; ENSG00000119725. [Q86VK4-2]
ENST00000442160; ENSP00000407130; ENSG00000119725. [Q86VK4-5]
ENST00000540593; ENSP00000442228; ENSG00000119725. [Q86VK4-4]
ENST00000555044; ENSP00000451763; ENSG00000119725. [Q86VK4-1]
ENST00000615736; ENSP00000483073; ENSG00000119725. [Q86VK4-5]
GeneIDi57862.
KEGGihsa:57862.
UCSCiuc001xoz.3. human. [Q86VK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90919 mRNA. Translation: AAB51059.1.
AK293350 mRNA. Translation: BAG56866.1.
AK299138 mRNA. Translation: BAG61190.1.
AC005480 Genomic DNA. No translation available.
AC005520 Genomic DNA. No translation available.
BC000330 mRNA. No translation available.
BC004357 mRNA. No translation available.
BC050683 mRNA. Translation: AAH50683.1.
CCDSiCCDS55929.1. [Q86VK4-5]
CCDS55930.1. [Q86VK4-3]
CCDS55931.1. [Q86VK4-4]
CCDS9821.1. [Q86VK4-1]
RefSeqiNP_001229853.1. NM_001242924.1. [Q86VK4-5]
NP_001229855.1. NM_001242926.1. [Q86VK4-3]
NP_001229856.1. NM_001242927.1. [Q86VK4-4]
NP_067011.1. NM_021188.2. [Q86VK4-1]
UniGeneiHs.270869.

3D structure databases

ProteinModelPortaliQ86VK4.
SMRiQ86VK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121792. 13 interactors.
IntActiQ86VK4. 32 interactors.
MINTiMINT-1425763.
STRINGi9606.ENSP00000407130.

PTM databases

iPTMnetiQ86VK4.
PhosphoSitePlusiQ86VK4.

Polymorphism and mutation databases

BioMutaiZNF410.
DMDMi37538029.

Proteomic databases

MaxQBiQ86VK4.
PaxDbiQ86VK4.
PeptideAtlasiQ86VK4.
PRIDEiQ86VK4.

Protocols and materials databases

DNASUi57862.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324593; ENSP00000323293; ENSG00000119725. [Q86VK4-3]
ENST00000398139; ENSP00000381208; ENSG00000119725. [Q86VK4-2]
ENST00000442160; ENSP00000407130; ENSG00000119725. [Q86VK4-5]
ENST00000540593; ENSP00000442228; ENSG00000119725. [Q86VK4-4]
ENST00000555044; ENSP00000451763; ENSG00000119725. [Q86VK4-1]
ENST00000615736; ENSP00000483073; ENSG00000119725. [Q86VK4-5]
GeneIDi57862.
KEGGihsa:57862.
UCSCiuc001xoz.3. human. [Q86VK4-1]

Organism-specific databases

CTDi57862.
DisGeNETi57862.
GeneCardsiZNF410.
HGNCiHGNC:20144. ZNF410.
HPAiHPA002871.
neXtProtiNX_Q86VK4.
OpenTargetsiENSG00000119725.
PharmGKBiPA134958929.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000069877.
HOVERGENiHBG055280.
InParanoidiQ86VK4.
OMAiDDTPNHT.
OrthoDBiEOG091G06YO.
PhylomeDBiQ86VK4.
TreeFamiTF333498.

Miscellaneous databases

ChiTaRSiZNF410. human.
GenomeRNAii57862.
PROiQ86VK4.

Gene expression databases

BgeeiENSG00000119725.
CleanExiHS_ZNF410.
ExpressionAtlasiQ86VK4. baseline and differential.
GenevisibleiQ86VK4. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN410_HUMAN
AccessioniPrimary (citable) accession number: Q86VK4
Secondary accession number(s): B4DDV5
, B4DR78, O00153, Q9BQ19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.