Q86VI4 (LAP4B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysosomal-associated transmembrane protein 4B

Alternative name(s):
Lysosome-associated transmembrane protein 4-beta

Gene names

Name:	LAPTM4B
ORF Names:	PSEC0001

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Endomembrane system; Multi-pass membrane protein Ref.1.
Sequence similarities	Belongs to the LAPTM4/LAPTM5 transporter family.
Sequence caution	The sequence CAB66876.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABCB1	P08183	2	EBI-3267258,EBI-1057359
PIK3R1	P27986	2	EBI-3267286,EBI-79464

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VI4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VI4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Isoform 3 (identifier: Q86VI4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Lysosomal-associated transmembrane protein 4B		PRO_0000249721
Regions
	Transmembrane	170 – 190	21	Helical; Potential
	Transmembrane	216 – 236	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential
	Transmembrane	297 – 317	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 144	144	Missing in isoform 2.		VSP_020544
	Alternative sequence	1 – 53	53	Missing in isoform 3.		VSP_020545
Experimental info
	Sequence conflict	138	1	R → S in AAH38117. Ref.5
	Sequence conflict	232	1	M → T in AAH38117. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A6C04BFCB8B26EC9	FASTA	370	41,146
	10 20 30 40 50 60 MELHERPDER RKARTSTQGR LGDWRRVHAD GFTHRVLGAP AAAWSSSSWL EPAMTSRTRV 70 80 90 100 110 120 TWPSPPRPLP VPAAAAVAFG AKGTDPAEAR SSRGIEEAGP RAHGRAGREP ERRRSRQQRR 130 140 150 160 170 180 GGLQARRSTL LKTCARARAT APGAMKMVAP WTRFYSNSCC LCCHVRTGTI LLGVWYLIIN 190 200 210 220 230 240 AVVLLILLSA LADPDQYNFS SSELGGDFEF MDDANMCIAI AISLLMILIC AMATYGAYKQ 250 260 270 280 290 300 RAAWIIPFFC YQIFDFALNM LVAITVLIYP NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL 310 320 330 340 350 360 IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP YDDATVNGAA 370 KEPPPPYVSA
	Isoform 2 [UniParc]. Checksum: A3156D2F2C0DCF0B	FASTA	226	25,419
	10 20 30 40 50 60 MKMVAPWTRF YSNSCCLCCH VRTGTILLGV WYLIINAVVL LILLSALADP DQYNFSSSEL 70 80 90 100 110 120 GGDFEFMDDA NMCIAIAISL LMILICAMAT YGAYKQRAAW IIPFFCYQIF DFALNMLVAI 130 140 150 160 170 180 TVLIYPNSIQ EYIRQLPPNF PYRDDVMSVN PTCLVLIILL FISIILTFKG YLISCVWNCY 190 200 210 220 RYINGRNSSD VLVYVTSNDT TVLLPPYDDA TVNGAAKEPP PPYVSA
	Isoform 3 [UniParc]. Checksum: 4E93093E066BE948	FASTA	317	35,123
	10 20 30 40 50 60 MTSRTRVTWP SPPRPLPVPA AAAVAFGAKG TDPAEARSSR GIEEAGPRAH GRAGREPERR 70 80 90 100 110 120 RSRQQRRGGL QARRSTLLKT CARARATAPG AMKMVAPWTR FYSNSCCLCC HVRTGTILLG 130 140 150 160 170 180 VWYLIINAVV LLILLSALAD PDQYNFSSSE LGGDFEFMDD ANMCIAIAIS LLMILICAMA 190 200 210 220 230 240 TYGAYKQRAA WIIPFFCYQI FDFALNMLVA ITVLIYPNSI QEYIRQLPPN FPYRDDVMSV 250 260 270 280 290 300 NPTCLVLIIL LFISIILTFK GYLISCVWNC YRYINGRNSS DVLVYVTSND TTVLLPPYDD 310 ATVNGAAKEP PPPYVSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma." Shao G.-Z., Zhou R.L., Zhang Q.Y., Zhang Y., Liu J.J., Rui J.A., Wei X., Ye D.X. Oncogene 22:5060-5069(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
[2]	Hogue D.L. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Uterus.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain, Eye and Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF527412 mRNA. Translation: AAP14034.1. AY057051 mRNA. Translation: AAL17908.2. AF317417 mRNA. Translation: AAK69595.1. AY261384 mRNA. Translation: AAO84265.1. AK075326 mRNA. Translation: BAC11549.1. AL136942 mRNA. Translation: CAB66876.2. Different initiation. BC014129 mRNA. Translation: AAH14129.1. BC031021 mRNA. Translation: AAH31021.1. BC038117 mRNA. Translation: AAH38117.1.
IPI	IPI00465172. IPI00743046. IPI00786974.
RefSeq	NP_060877.3. NM_018407.4.
UniGene	Hs.492314.
3D structure databases
ProteinModelPortal	Q86VI4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VI4. 2 interactions.
MINT	MINT-4726487.
STRING	9606.ENSP00000220781.
PTM databases
PhosphoSite	Q86VI4.
Polymorphism databases
DMDM	74714056.
Proteomic databases
PaxDb	Q86VI4.
PRIDE	Q86VI4.
Protocols and materials databases
DNASU	55353.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000445593; ENSP00000402301; ENSG00000104341. ENST00000521545; ENSP00000428409; ENSG00000104341.
GeneID	55353.
KEGG	hsa:55353.
UCSC	uc003yia.3. human.
Organism-specific databases
CTD	55353.
GeneCards	GC08P098787.
HGNC	HGNC:13646. LAPTM4B.
HPA	CAB020782.
MIM	613296. gene.
neXtProt	NX_Q86VI4.
PharmGKB	PA128395785.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46169.
HOGENOM	HOG000007698.
HOVERGEN	HBG000908.
InParanoid	Q86VI4.
KO	K12387.
OrthoDB	EOG47WNPC.
Gene expression databases
ArrayExpress	Q86VI4.
Bgee	Q86VI4.
CleanEx	HS_LAPTM4B.
Genevestigator	Q86VI4.
GermOnline	ENSG00000104341. Homo sapiens.
Family and domain databases
InterPro	IPR004687. LAPTM4/5. IPR018401. Lysosomal-assoc_TM_prot4B. [Graphical view]
PANTHER	PTHR12479. PTHR12479. 1 hit. PTHR12479:SF6. PTHR12479:SF6. 1 hit.
Pfam	PF03821. Mtp. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55353.
NextBio	59711.
SOURCE	Search...

Entry information

Entry name

LAP4B_HUMAN

Accession

Primary (citable) accession number: Q86VI4
Secondary accession number(s): Q3ZCV5 , Q7L909, Q86VH8, Q9H060

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.