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Q86VI4

- LAP4B_HUMAN

UniProt

Q86VI4 - LAP4B_HUMAN

Protein

Lysosomal-associated transmembrane protein 4B

Gene

LAPTM4B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.74.1.3. the 4 tms multidrug endosomal transporter (met) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal-associated transmembrane protein 4B
    Alternative name(s):
    Lysosome-associated transmembrane protein 4-beta
    Gene namesi
    Name:LAPTM4B
    ORF Names:PSEC0001
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:13646. LAPTM4B.

    Subcellular locationi

    Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128395785.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Lysosomal-associated transmembrane protein 4BPRO_0000249721Add
    BLAST

    Proteomic databases

    MaxQBiQ86VI4.
    PaxDbiQ86VI4.
    PRIDEiQ86VI4.

    PTM databases

    PhosphoSiteiQ86VI4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86VI4.
    BgeeiQ86VI4.
    CleanExiHS_LAPTM4B.
    GenevestigatoriQ86VI4.

    Organism-specific databases

    HPAiCAB020782.
    HPA014996.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABCB1P081832EBI-3267258,EBI-1057359
    PIK3R1P279862EBI-3267286,EBI-79464

    Protein-protein interaction databases

    BioGridi120633. 3 interactions.
    IntActiQ86VI4. 2 interactions.
    MINTiMINT-4726487.
    STRINGi9606.ENSP00000220781.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LAPTM4/LAPTM5 transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46169.
    HOGENOMiHOG000007698.
    HOVERGENiHBG000908.
    InParanoidiQ86VI4.
    KOiK12387.
    OMAiTIILGIW.
    OrthoDBiEOG7QC7X3.
    PhylomeDBiQ86VI4.
    TreeFamiTF330843.

    Family and domain databases

    InterProiIPR004687. LAPTM4/5.
    IPR018401. Lysosomal-assoc_TM_prot4B.
    [Graphical view]
    PANTHERiPTHR12479. PTHR12479. 1 hit.
    PTHR12479:SF6. PTHR12479:SF6. 1 hit.
    PfamiPF03821. Mtp. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86VI4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELHERPDER RKARTSTQGR LGDWRRVHAD GFTHRVLGAP AAAWSSSSWL    50
    EPAMTSRTRV TWPSPPRPLP VPAAAAVAFG AKGTDPAEAR SSRGIEEAGP 100
    RAHGRAGREP ERRRSRQQRR GGLQARRSTL LKTCARARAT APGAMKMVAP 150
    WTRFYSNSCC LCCHVRTGTI LLGVWYLIIN AVVLLILLSA LADPDQYNFS 200
    SSELGGDFEF MDDANMCIAI AISLLMILIC AMATYGAYKQ RAAWIIPFFC 250
    YQIFDFALNM LVAITVLIYP NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL 300
    IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP 350
    YDDATVNGAA KEPPPPYVSA 370
    Length:370
    Mass (Da):41,146
    Last modified:June 1, 2003 - v1
    Checksum:iA6C04BFCB8B26EC9
    GO
    Isoform 2 (identifier: Q86VI4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-144: Missing.

    Show »
    Length:226
    Mass (Da):25,419
    Checksum:iA3156D2F2C0DCF0B
    GO
    Isoform 3 (identifier: Q86VI4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-53: Missing.

    Show »
    Length:317
    Mass (Da):35,123
    Checksum:i4E93093E066BE948
    GO

    Sequence cautioni

    The sequence CAB66876.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381R → S in AAH38117. (PubMed:15489334)Curated
    Sequence conflicti232 – 2321M → T in AAH38117. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 144144Missing in isoform 2. 2 PublicationsVSP_020544Add
    BLAST
    Alternative sequencei1 – 5353Missing in isoform 3. 4 PublicationsVSP_020545Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF527412 mRNA. Translation: AAP14034.1.
    AY057051 mRNA. Translation: AAL17908.2.
    AF317417 mRNA. Translation: AAK69595.1.
    AY261384 mRNA. Translation: AAO84265.1.
    AK075326 mRNA. Translation: BAC11549.1.
    AL136942 mRNA. Translation: CAB66876.2. Different initiation.
    BC014129 mRNA. Translation: AAH14129.1.
    BC031021 mRNA. Translation: AAH31021.1.
    BC038117 mRNA. Translation: AAH38117.1.
    CCDSiCCDS6275.1. [Q86VI4-3]
    RefSeqiNP_060877.3. NM_018407.4. [Q86VI4-3]
    UniGeneiHs.492314.

    Genome annotation databases

    EnsembliENST00000445593; ENSP00000402301; ENSG00000104341. [Q86VI4-3]
    ENST00000521545; ENSP00000428409; ENSG00000104341. [Q86VI4-2]
    GeneIDi55353.
    KEGGihsa:55353.
    UCSCiuc003yia.3. human. [Q86VI4-1]

    Polymorphism databases

    DMDMi74714056.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF527412 mRNA. Translation: AAP14034.1 .
    AY057051 mRNA. Translation: AAL17908.2 .
    AF317417 mRNA. Translation: AAK69595.1 .
    AY261384 mRNA. Translation: AAO84265.1 .
    AK075326 mRNA. Translation: BAC11549.1 .
    AL136942 mRNA. Translation: CAB66876.2 . Different initiation.
    BC014129 mRNA. Translation: AAH14129.1 .
    BC031021 mRNA. Translation: AAH31021.1 .
    BC038117 mRNA. Translation: AAH38117.1 .
    CCDSi CCDS6275.1. [Q86VI4-3 ]
    RefSeqi NP_060877.3. NM_018407.4. [Q86VI4-3 ]
    UniGenei Hs.492314.

    3D structure databases

    ProteinModelPortali Q86VI4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120633. 3 interactions.
    IntActi Q86VI4. 2 interactions.
    MINTi MINT-4726487.
    STRINGi 9606.ENSP00000220781.

    Protein family/group databases

    TCDBi 2.A.74.1.3. the 4 tms multidrug endosomal transporter (met) family.

    PTM databases

    PhosphoSitei Q86VI4.

    Polymorphism databases

    DMDMi 74714056.

    Proteomic databases

    MaxQBi Q86VI4.
    PaxDbi Q86VI4.
    PRIDEi Q86VI4.

    Protocols and materials databases

    DNASUi 55353.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000445593 ; ENSP00000402301 ; ENSG00000104341 . [Q86VI4-3 ]
    ENST00000521545 ; ENSP00000428409 ; ENSG00000104341 . [Q86VI4-2 ]
    GeneIDi 55353.
    KEGGi hsa:55353.
    UCSCi uc003yia.3. human. [Q86VI4-1 ]

    Organism-specific databases

    CTDi 55353.
    GeneCardsi GC08P098787.
    HGNCi HGNC:13646. LAPTM4B.
    HPAi CAB020782.
    HPA014996.
    MIMi 613296. gene.
    neXtProti NX_Q86VI4.
    PharmGKBi PA128395785.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46169.
    HOGENOMi HOG000007698.
    HOVERGENi HBG000908.
    InParanoidi Q86VI4.
    KOi K12387.
    OMAi TIILGIW.
    OrthoDBi EOG7QC7X3.
    PhylomeDBi Q86VI4.
    TreeFami TF330843.

    Miscellaneous databases

    GeneWikii LAPTM4B.
    GenomeRNAii 55353.
    NextBioi 59711.
    PROi Q86VI4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86VI4.
    Bgeei Q86VI4.
    CleanExi HS_LAPTM4B.
    Genevestigatori Q86VI4.

    Family and domain databases

    InterProi IPR004687. LAPTM4/5.
    IPR018401. Lysosomal-assoc_TM_prot4B.
    [Graphical view ]
    PANTHERi PTHR12479. PTHR12479. 1 hit.
    PTHR12479:SF6. PTHR12479:SF6. 1 hit.
    Pfami PF03821. Mtp. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma."
      Shao G.-Z., Zhou R.L., Zhang Q.Y., Zhang Y., Liu J.J., Rui J.A., Wei X., Ye D.X.
      Oncogene 22:5060-5069(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
    2. Hogue D.L.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Uterus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain, Eye and Lung.

    Entry informationi

    Entry nameiLAP4B_HUMAN
    AccessioniPrimary (citable) accession number: Q86VI4
    Secondary accession number(s): Q3ZCV5
    , Q7L909, Q86VH8, Q9H060
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3