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Q86VI4

- LAP4B_HUMAN

UniProt

Q86VI4 - LAP4B_HUMAN

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Protein

Lysosomal-associated transmembrane protein 4B

Gene

LAPTM4B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.74.1.3. the 4 tms multidrug endosomal transporter (met) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4B
Alternative name(s):
Lysosome-associated transmembrane protein 4-beta
Gene namesi
Name:LAPTM4B
ORF Names:PSEC0001
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:13646. LAPTM4B.

Subcellular locationi

Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128395785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Lysosomal-associated transmembrane protein 4BPRO_0000249721Add
BLAST

Proteomic databases

MaxQBiQ86VI4.
PaxDbiQ86VI4.
PRIDEiQ86VI4.

PTM databases

PhosphoSiteiQ86VI4.

Expressioni

Gene expression databases

BgeeiQ86VI4.
CleanExiHS_LAPTM4B.
ExpressionAtlasiQ86VI4. baseline and differential.
GenevestigatoriQ86VI4.

Organism-specific databases

HPAiCAB020782.
HPA014996.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABCB1P081832EBI-3267258,EBI-1057359
PIK3R1P279862EBI-3267286,EBI-79464

Protein-protein interaction databases

BioGridi120633. 8 interactions.
IntActiQ86VI4. 2 interactions.
MINTiMINT-4726487.
STRINGi9606.ENSP00000220781.

Structurei

3D structure databases

ProteinModelPortaliQ86VI4.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46169.
GeneTreeiENSGT00390000013359.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ86VI4.
KOiK12387.
OMAiTIILGIW.
OrthoDBiEOG7QC7X3.
PhylomeDBiQ86VI4.
TreeFamiTF330843.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86VI4) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELHERPDER RKARTSTQGR LGDWRRVHAD GFTHRVLGAP AAAWSSSSWL
60 70 80 90 100
EPAMTSRTRV TWPSPPRPLP VPAAAAVAFG AKGTDPAEAR SSRGIEEAGP
110 120 130 140 150
RAHGRAGREP ERRRSRQQRR GGLQARRSTL LKTCARARAT APGAMKMVAP
160 170 180 190 200
WTRFYSNSCC LCCHVRTGTI LLGVWYLIIN AVVLLILLSA LADPDQYNFS
210 220 230 240 250
SSELGGDFEF MDDANMCIAI AISLLMILIC AMATYGAYKQ RAAWIIPFFC
260 270 280 290 300
YQIFDFALNM LVAITVLIYP NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL
310 320 330 340 350
IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP
360 370
YDDATVNGAA KEPPPPYVSA
Length:370
Mass (Da):41,146
Last modified:June 1, 2003 - v1
Checksum:iA6C04BFCB8B26EC9
GO
Isoform 2 (identifier: Q86VI4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Show »
Length:226
Mass (Da):25,419
Checksum:iA3156D2F2C0DCF0B
GO
Isoform 3 (identifier: Q86VI4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:317
Mass (Da):35,123
Checksum:i4E93093E066BE948
GO

Sequence cautioni

The sequence CAB66876.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381R → S in AAH38117. (PubMed:15489334)Curated
Sequence conflicti232 – 2321M → T in AAH38117. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 144144Missing in isoform 2. 2 PublicationsVSP_020544Add
BLAST
Alternative sequencei1 – 5353Missing in isoform 3. 4 PublicationsVSP_020545Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF527412 mRNA. Translation: AAP14034.1.
AY057051 mRNA. Translation: AAL17908.2.
AF317417 mRNA. Translation: AAK69595.1.
AY261384 mRNA. Translation: AAO84265.1.
AK075326 mRNA. Translation: BAC11549.1.
AL136942 mRNA. Translation: CAB66876.2. Different initiation.
BC014129 mRNA. Translation: AAH14129.1.
BC031021 mRNA. Translation: AAH31021.1.
BC038117 mRNA. Translation: AAH38117.1.
CCDSiCCDS6275.1. [Q86VI4-3]
RefSeqiNP_060877.3. NM_018407.4. [Q86VI4-3]
UniGeneiHs.492314.

Genome annotation databases

EnsembliENST00000445593; ENSP00000402301; ENSG00000104341. [Q86VI4-3]
ENST00000521545; ENSP00000428409; ENSG00000104341. [Q86VI4-2]
ENST00000619747; ENSP00000482533; ENSG00000104341. [Q86VI4-3]
GeneIDi55353.
KEGGihsa:55353.
UCSCiuc003yia.3. human. [Q86VI4-1]

Polymorphism databases

DMDMi74714056.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF527412 mRNA. Translation: AAP14034.1 .
AY057051 mRNA. Translation: AAL17908.2 .
AF317417 mRNA. Translation: AAK69595.1 .
AY261384 mRNA. Translation: AAO84265.1 .
AK075326 mRNA. Translation: BAC11549.1 .
AL136942 mRNA. Translation: CAB66876.2 . Different initiation.
BC014129 mRNA. Translation: AAH14129.1 .
BC031021 mRNA. Translation: AAH31021.1 .
BC038117 mRNA. Translation: AAH38117.1 .
CCDSi CCDS6275.1. [Q86VI4-3 ]
RefSeqi NP_060877.3. NM_018407.4. [Q86VI4-3 ]
UniGenei Hs.492314.

3D structure databases

ProteinModelPortali Q86VI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120633. 8 interactions.
IntActi Q86VI4. 2 interactions.
MINTi MINT-4726487.
STRINGi 9606.ENSP00000220781.

Protein family/group databases

TCDBi 2.A.74.1.3. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

PhosphoSitei Q86VI4.

Polymorphism databases

DMDMi 74714056.

Proteomic databases

MaxQBi Q86VI4.
PaxDbi Q86VI4.
PRIDEi Q86VI4.

Protocols and materials databases

DNASUi 55353.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000445593 ; ENSP00000402301 ; ENSG00000104341 . [Q86VI4-3 ]
ENST00000521545 ; ENSP00000428409 ; ENSG00000104341 . [Q86VI4-2 ]
ENST00000619747 ; ENSP00000482533 ; ENSG00000104341 . [Q86VI4-3 ]
GeneIDi 55353.
KEGGi hsa:55353.
UCSCi uc003yia.3. human. [Q86VI4-1 ]

Organism-specific databases

CTDi 55353.
GeneCardsi GC08P098787.
HGNCi HGNC:13646. LAPTM4B.
HPAi CAB020782.
HPA014996.
MIMi 613296. gene.
neXtProti NX_Q86VI4.
PharmGKBi PA128395785.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46169.
GeneTreei ENSGT00390000013359.
HOGENOMi HOG000007698.
HOVERGENi HBG000908.
InParanoidi Q86VI4.
KOi K12387.
OMAi TIILGIW.
OrthoDBi EOG7QC7X3.
PhylomeDBi Q86VI4.
TreeFami TF330843.

Miscellaneous databases

GeneWikii LAPTM4B.
GenomeRNAii 55353.
NextBioi 59711.
PROi Q86VI4.
SOURCEi Search...

Gene expression databases

Bgeei Q86VI4.
CleanExi HS_LAPTM4B.
ExpressionAtlasi Q86VI4. baseline and differential.
Genevestigatori Q86VI4.

Family and domain databases

InterProi IPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view ]
PANTHERi PTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
Pfami PF03821. Mtp. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma."
    Shao G.-Z., Zhou R.L., Zhang Q.Y., Zhang Y., Liu J.J., Rui J.A., Wei X., Ye D.X.
    Oncogene 22:5060-5069(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
  2. Hogue D.L.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Uterus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain, Eye and Lung.

Entry informationi

Entry nameiLAP4B_HUMAN
AccessioniPrimary (citable) accession number: Q86VI4
Secondary accession number(s): Q3ZCV5
, Q7L909, Q86VH8, Q9H060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3