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Protein

Lysosomal-associated transmembrane protein 4B

Gene

LAPTM4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.74.1.3. the 4 tms multidrug endosomal transporter (met) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4B
Alternative name(s):
Lysosome-associated transmembrane protein 4-beta
Gene namesi
Name:LAPTM4B
ORF Names:PSEC0001
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:13646. LAPTM4B.

Subcellular locationi

Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endomembrane system Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128395785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Lysosomal-associated transmembrane protein 4BPRO_0000249721Add
BLAST

Proteomic databases

MaxQBiQ86VI4.
PaxDbiQ86VI4.
PRIDEiQ86VI4.

PTM databases

PhosphoSiteiQ86VI4.

Expressioni

Gene expression databases

BgeeiQ86VI4.
CleanExiHS_LAPTM4B.
ExpressionAtlasiQ86VI4. baseline and differential.
GenevestigatoriQ86VI4.

Organism-specific databases

HPAiCAB020782.
HPA014996.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABCB1P081832EBI-3267258,EBI-1057359
PIK3R1P279862EBI-3267286,EBI-79464

Protein-protein interaction databases

BioGridi120633. 9 interactions.
IntActiQ86VI4. 2 interactions.
MINTiMINT-4726487.
STRINGi9606.ENSP00000220781.

Structurei

3D structure databases

ProteinModelPortaliQ86VI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46169.
GeneTreeiENSGT00390000013359.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ86VI4.
KOiK12387.
OMAiMSTNNMC.
OrthoDBiEOG7QC7X3.
PhylomeDBiQ86VI4.
TreeFamiTF330843.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELHERPDER RKARTSTQGR LGDWRRVHAD GFTHRVLGAP AAAWSSSSWL
60 70 80 90 100
EPAMTSRTRV TWPSPPRPLP VPAAAAVAFG AKGTDPAEAR SSRGIEEAGP
110 120 130 140 150
RAHGRAGREP ERRRSRQQRR GGLQARRSTL LKTCARARAT APGAMKMVAP
160 170 180 190 200
WTRFYSNSCC LCCHVRTGTI LLGVWYLIIN AVVLLILLSA LADPDQYNFS
210 220 230 240 250
SSELGGDFEF MDDANMCIAI AISLLMILIC AMATYGAYKQ RAAWIIPFFC
260 270 280 290 300
YQIFDFALNM LVAITVLIYP NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL
310 320 330 340 350
IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP
360 370
YDDATVNGAA KEPPPPYVSA
Length:370
Mass (Da):41,146
Last modified:May 31, 2003 - v1
Checksum:iA6C04BFCB8B26EC9
GO
Isoform 2 (identifier: Q86VI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Show »
Length:226
Mass (Da):25,419
Checksum:iA3156D2F2C0DCF0B
GO
Isoform 3 (identifier: Q86VI4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:317
Mass (Da):35,123
Checksum:i4E93093E066BE948
GO

Sequence cautioni

The sequence CAB66876.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381R → S in AAH38117 (PubMed:15489334).Curated
Sequence conflicti232 – 2321M → T in AAH38117 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 144144Missing in isoform 2. 2 PublicationsVSP_020544Add
BLAST
Alternative sequencei1 – 5353Missing in isoform 3. 4 PublicationsVSP_020545Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527412 mRNA. Translation: AAP14034.1.
AY057051 mRNA. Translation: AAL17908.2.
AF317417 mRNA. Translation: AAK69595.1.
AY261384 mRNA. Translation: AAO84265.1.
AK075326 mRNA. Translation: BAC11549.1.
AL136942 mRNA. Translation: CAB66876.2. Different initiation.
BC014129 mRNA. Translation: AAH14129.1.
BC031021 mRNA. Translation: AAH31021.1.
BC038117 mRNA. Translation: AAH38117.1.
CCDSiCCDS6275.1. [Q86VI4-3]
RefSeqiNP_060877.3. NM_018407.4. [Q86VI4-3]
UniGeneiHs.492314.

Genome annotation databases

EnsembliENST00000445593; ENSP00000402301; ENSG00000104341. [Q86VI4-3]
ENST00000521545; ENSP00000428409; ENSG00000104341. [Q86VI4-2]
ENST00000619747; ENSP00000482533; ENSG00000104341. [Q86VI4-3]
GeneIDi55353.
KEGGihsa:55353.
UCSCiuc003yia.3. human. [Q86VI4-1]

Polymorphism databases

DMDMi74714056.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527412 mRNA. Translation: AAP14034.1.
AY057051 mRNA. Translation: AAL17908.2.
AF317417 mRNA. Translation: AAK69595.1.
AY261384 mRNA. Translation: AAO84265.1.
AK075326 mRNA. Translation: BAC11549.1.
AL136942 mRNA. Translation: CAB66876.2. Different initiation.
BC014129 mRNA. Translation: AAH14129.1.
BC031021 mRNA. Translation: AAH31021.1.
BC038117 mRNA. Translation: AAH38117.1.
CCDSiCCDS6275.1. [Q86VI4-3]
RefSeqiNP_060877.3. NM_018407.4. [Q86VI4-3]
UniGeneiHs.492314.

3D structure databases

ProteinModelPortaliQ86VI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120633. 9 interactions.
IntActiQ86VI4. 2 interactions.
MINTiMINT-4726487.
STRINGi9606.ENSP00000220781.

Protein family/group databases

TCDBi2.A.74.1.3. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

PhosphoSiteiQ86VI4.

Polymorphism databases

DMDMi74714056.

Proteomic databases

MaxQBiQ86VI4.
PaxDbiQ86VI4.
PRIDEiQ86VI4.

Protocols and materials databases

DNASUi55353.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445593; ENSP00000402301; ENSG00000104341. [Q86VI4-3]
ENST00000521545; ENSP00000428409; ENSG00000104341. [Q86VI4-2]
ENST00000619747; ENSP00000482533; ENSG00000104341. [Q86VI4-3]
GeneIDi55353.
KEGGihsa:55353.
UCSCiuc003yia.3. human. [Q86VI4-1]

Organism-specific databases

CTDi55353.
GeneCardsiGC08P098787.
HGNCiHGNC:13646. LAPTM4B.
HPAiCAB020782.
HPA014996.
MIMi613296. gene.
neXtProtiNX_Q86VI4.
PharmGKBiPA128395785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46169.
GeneTreeiENSGT00390000013359.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ86VI4.
KOiK12387.
OMAiMSTNNMC.
OrthoDBiEOG7QC7X3.
PhylomeDBiQ86VI4.
TreeFamiTF330843.

Miscellaneous databases

GeneWikiiLAPTM4B.
GenomeRNAii55353.
NextBioi59711.
PROiQ86VI4.
SOURCEiSearch...

Gene expression databases

BgeeiQ86VI4.
CleanExiHS_LAPTM4B.
ExpressionAtlasiQ86VI4. baseline and differential.
GenevestigatoriQ86VI4.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma."
    Shao G.-Z., Zhou R.L., Zhang Q.Y., Zhang Y., Liu J.J., Rui J.A., Wei X., Ye D.X.
    Oncogene 22:5060-5069(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
  2. Hogue D.L.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Uterus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain, Eye and Lung.

Entry informationi

Entry nameiLAP4B_HUMAN
AccessioniPrimary (citable) accession number: Q86VI4
Secondary accession number(s): Q3ZCV5
, Q7L909, Q86VH8, Q9H060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 18, 2006
Last sequence update: May 31, 2003
Last modified: February 3, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.