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Q86VI4 (LAP4B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosomal-associated transmembrane protein 4B
Alternative name(s):
Lysosome-associated transmembrane protein 4-beta
Gene names
Name:LAPTM4B
ORF Names:PSEC0001
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endomembrane system; Multi-pass membrane protein Ref.1.

Sequence similarities

Belongs to the LAPTM4/LAPTM5 transporter family.

Sequence caution

The sequence CAB66876.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendomembrane system

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 20711237PubMed 20711237. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ABCB1P081832EBI-3267258,EBI-1057359
PIK3R1P279862EBI-3267286,EBI-79464

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86VI4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86VI4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
Isoform 3 (identifier: Q86VI4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Lysosomal-associated transmembrane protein 4B
PRO_0000249721

Regions

Transmembrane170 – 19021Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane244 – 26421Helical; Potential
Transmembrane297 – 31721Helical; Potential

Natural variations

Alternative sequence1 – 144144Missing in isoform 2.
VSP_020544
Alternative sequence1 – 5353Missing in isoform 3.
VSP_020545

Experimental info

Sequence conflict1381R → S in AAH38117. Ref.5
Sequence conflict2321M → T in AAH38117. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A6C04BFCB8B26EC9

FASTA37041,146
        10         20         30         40         50         60 
MELHERPDER RKARTSTQGR LGDWRRVHAD GFTHRVLGAP AAAWSSSSWL EPAMTSRTRV 

        70         80         90        100        110        120 
TWPSPPRPLP VPAAAAVAFG AKGTDPAEAR SSRGIEEAGP RAHGRAGREP ERRRSRQQRR 

       130        140        150        160        170        180 
GGLQARRSTL LKTCARARAT APGAMKMVAP WTRFYSNSCC LCCHVRTGTI LLGVWYLIIN 

       190        200        210        220        230        240 
AVVLLILLSA LADPDQYNFS SSELGGDFEF MDDANMCIAI AISLLMILIC AMATYGAYKQ 

       250        260        270        280        290        300 
RAAWIIPFFC YQIFDFALNM LVAITVLIYP NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL 

       310        320        330        340        350        360 
IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP YDDATVNGAA 

       370 
KEPPPPYVSA 

« Hide

Isoform 2 [UniParc].

Checksum: A3156D2F2C0DCF0B
Show »

FASTA22625,419
Isoform 3 [UniParc].

Checksum: 4E93093E066BE948
Show »

FASTA31735,123

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma."
Shao G.-Z., Zhou R.L., Zhang Q.Y., Zhang Y., Liu J.J., Rui J.A., Wei X., Ye D.X.
Oncogene 22:5060-5069(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
[2]Hogue D.L.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Uterus.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Brain, Eye and Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF527412 mRNA. Translation: AAP14034.1.
AY057051 mRNA. Translation: AAL17908.2.
AF317417 mRNA. Translation: AAK69595.1.
AY261384 mRNA. Translation: AAO84265.1.
AK075326 mRNA. Translation: BAC11549.1.
AL136942 mRNA. Translation: CAB66876.2. Different initiation.
BC014129 mRNA. Translation: AAH14129.1.
BC031021 mRNA. Translation: AAH31021.1.
BC038117 mRNA. Translation: AAH38117.1.
CCDSCCDS6275.1. [Q86VI4-3]
RefSeqNP_060877.3. NM_018407.4. [Q86VI4-3]
UniGeneHs.492314.

3D structure databases

ProteinModelPortalQ86VI4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120633. 3 interactions.
IntActQ86VI4. 2 interactions.
MINTMINT-4726487.
STRING9606.ENSP00000220781.

Protein family/group databases

TCDB2.A.74.1.3. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

PhosphoSiteQ86VI4.

Polymorphism databases

DMDM74714056.

Proteomic databases

MaxQBQ86VI4.
PaxDbQ86VI4.
PRIDEQ86VI4.

Protocols and materials databases

DNASU55353.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000445593; ENSP00000402301; ENSG00000104341. [Q86VI4-3]
ENST00000521545; ENSP00000428409; ENSG00000104341. [Q86VI4-2]
GeneID55353.
KEGGhsa:55353.
UCSCuc003yia.3. human. [Q86VI4-1]

Organism-specific databases

CTD55353.
GeneCardsGC08P098787.
HGNCHGNC:13646. LAPTM4B.
HPACAB020782.
HPA014996.
MIM613296. gene.
neXtProtNX_Q86VI4.
PharmGKBPA128395785.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46169.
HOGENOMHOG000007698.
HOVERGENHBG000908.
InParanoidQ86VI4.
KOK12387.
OMATIILGIW.
OrthoDBEOG7QC7X3.
PhylomeDBQ86VI4.
TreeFamTF330843.

Gene expression databases

ArrayExpressQ86VI4.
BgeeQ86VI4.
CleanExHS_LAPTM4B.
GenevestigatorQ86VI4.

Family and domain databases

InterProIPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view]
PANTHERPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
PfamPF03821. Mtp. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLAPTM4B.
GenomeRNAi55353.
NextBio59711.
PROQ86VI4.
SOURCESearch...

Entry information

Entry nameLAP4B_HUMAN
AccessionPrimary (citable) accession number: Q86VI4
Secondary accession number(s): Q3ZCV5 expand/collapse secondary AC list , Q7L909, Q86VH8, Q9H060
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM