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Protein

Ras GTPase-activating-like protein IQGAP3

Gene

IQGAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • myosin VI light chain binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30690-MONOMER.
ReactomeiR-HSA-5626467. RHO GTPases activate IQGAPs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating-like protein IQGAP3
Gene namesi
Name:IQGAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20669. IQGAP3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi128239.
OpenTargetsiENSG00000183856.
PharmGKBiPA134954177.

Polymorphism and mutation databases

BioMutaiIQGAP3.
DMDMi229462887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566511 – 1631Ras GTPase-activating-like protein IQGAP3Add BLAST1631

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphotyrosineBy similarity1
Modified residuei539PhosphoserineCombined sources1
Modified residuei1424PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86VI3.
MaxQBiQ86VI3.
PaxDbiQ86VI3.
PeptideAtlasiQ86VI3.
PRIDEiQ86VI3.

PTM databases

iPTMnetiQ86VI3.
PhosphoSitePlusiQ86VI3.

Expressioni

Gene expression databases

BgeeiENSG00000183856.
CleanExiHS_IQGAP3.
ExpressionAtlasiQ86VI3. baseline and differential.
GenevisibleiQ86VI3. HS.

Organism-specific databases

HPAiHPA030142.
HPA030143.

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • myosin VI light chain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126102. 27 interactors.
IntActiQ86VI3. 12 interactors.
MINTiMINT-8330040.
STRINGi9606.ENSP00000354451.

Structurei

Secondary structure

11631
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1535 – 1538Combined sources4
Helixi1539 – 1544Combined sources6
Beta strandi1547 – 1551Combined sources5
Helixi1556 – 1561Combined sources6
Beta strandi1562 – 1568Combined sources7
Beta strandi1574 – 1581Combined sources8
Beta strandi1589 – 1592Combined sources4
Helixi1593 – 1601Combined sources9
Beta strandi1606 – 1609Combined sources4
Turni1610 – 1612Combined sources3
Beta strandi1613 – 1616Combined sources4
Helixi1617 – 1627Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ISUX-ray1.88A1529-1631[»]
ProteinModelPortaliQ86VI3.
SMRiQ86VI3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86VI3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 149CHPROSITE-ProRule annotationAdd BLAST116
Domaini730 – 759IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini760 – 789IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini790 – 819IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini820 – 849IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini988 – 1221Ras-GAPPROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 4 IQ domains.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2128. Eukaryota.
COG5261. LUCA.
GeneTreeiENSGT00600000084379.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
InParanoidiQ86VI3.
KOiK05767.
OMAiYRNGRGQ.
OrthoDBiEOG091G00ET.
PhylomeDBiQ86VI3.
TreeFamiTF313078.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 4 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 4 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 4 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRAAGPGW AAYERLTAEE MDEQRRQNVA YQYLCRLEEA KRWMEACLKE
60 70 80 90 100
ELPSPVELEE SLRNGVLLAK LGHCFAPSVV PLKKIYDVEQ LRYQATGLHF
110 120 130 140 150
RHTDNINFWL SAIAHIGLPS TFFPETTDIY DKKNMPRVVY CIHALSLFLF
160 170 180 190 200
RLGLAPQIHD LYGKVKFTAE ELSNMASELA KYGLQLPAFS KIGGILANEL
210 220 230 240 250
SVDEAAVHAA VLAINEAVER GVVEDTLAAL QNPSALLENL REPLAAVYQE
260 270 280 290 300
MLAQAKMEKA ANARNHDDRE SQDIYDHYLT QAEIQGNINH VNVHGALEVV
310 320 330 340 350
DDALERQSPE ALLKALQDPA LALRGVRRDF ADWYLEQLNS DREQKAQELG
360 370 380 390 400
LVELLEKEEV QAGVAAANTK GDQEQAMLHA VQRINKAIRR RVAADTVKEL
410 420 430 440 450
MCPEAQLPPV YPVASSMYQL ELAVLQQQQG ELGQEELFVA VEMLSAVVLI
460 470 480 490 500
NRALEARDAS GFWSSLVNPA TGLAEVEGEN AQRYFDALLK LRQERGMGED
510 520 530 540 550
FLSWNDLQAT VSQVNAQTQE ETDRVLAVSL INEALDKGSP EKTLSALLLP
560 570 580 590 600
AAGLDDVSLP VAPRYHLLLV AAKRQKAQVT GDPGAVLWLE EIRQGVVRAN
610 620 630 640 650
QDTNTAQRMA LGVAAINQAI KEGKAAQTER VLRNPAVALR GVVPDCANGY
660 670 680 690 700
QRALESAMAK KQRPADTAFW VQHDMKDGTA YYFHLQTFQG IWEQPPGCPL
710 720 730 740 750
NTSHLTREEI QSAVTKVTAA YDRQQLWKAN VGFVIQLQAR LRGFLVRQKF
760 770 780 790 800
AEHSHFLRTW LPAVIKIQAH WRGYRQRKIY LEWLQYFKAN LDAIIKIQAW
810 820 830 840 850
ARMWAARRQY LRRLHYFQKN VNSIVKIQAF FRARKAQDDY RILVHAPHPP
860 870 880 890 900
LSVVRRFAHL LNQSQQDFLA EAELLKLQEE VVRKIRSNQQ LEQDLNIMDI
910 920 930 940 950
KIGLLVKNRI TLQEVVSHCK KLTKRNKEQL SDMMVLDKQK GLKSLSKEKR
960 970 980 990 1000
QKLEAYQHLF YLLQTQPIYL AKLIFQMPQN KTTKFMEAVI FSLYNYASSR
1010 1020 1030 1040 1050
REAYLLLQLF KTALQEEIKS KVEQPQDVVT GNPTVVRLVV RFYRNGRGQS
1060 1070 1080 1090 1100
ALQEILGKVI QDVLEDKVLS VHTDPVHLYK NWINQTEAQT GQRSHLPYDV
1110 1120 1130 1140 1150
TPEQALSHPE VQRRLDIALR NLLAMTDKFL LAITSSVDQI PYGMRYVAKV
1160 1170 1180 1190 1200
LKATLAEKFP DATDSEVYKV VGNLLYYRFL NPAVVAPDAF DIVAMAAGGA
1210 1220 1230 1240 1250
LAAPQRHALG AVAQLLQHAA AGKAFSGQSQ HLRVLNDYLE ETHLKFRKFI
1260 1270 1280 1290 1300
HRACQVPEPE ERFAVDEYSD MVAVAKPMVY ITVGELVNTH RLLLEHQDCI
1310 1320 1330 1340 1350
APDHQDPLHE LLEDLGELPT IPDLIGESIA ADGHTDLSKL EVSLTLTNKF
1360 1370 1380 1390 1400
EGLEADADDS NTRSLLLSTK QLLADIIQFH PGDTLKEILS LSASREQEAA
1410 1420 1430 1440 1450
HKQLMSRRQA CTAQTPEPLR RHRSLTAHSL LPLAEKQRRV LRNLRRLEAL
1460 1470 1480 1490 1500
GLVSARNGYQ GLVDELAKDI RNQHRHRHRR KAELVKLQAT LQGLSTKTTF
1510 1520 1530 1540 1550
YEEQGDYYSQ YIRACLDHLA PDSKSSGKGK KQPSLHYTAA QLLEKGVLVE
1560 1570 1580 1590 1600
IEDLPASHFR NVIFDITPGD EAGKFEVNAK FLGVDMERFQ LHYQDLLQLQ
1610 1620 1630
YEGVAVMKLF NKAKVNVNLL IFLLNKKFLR K
Length:1,631
Mass (Da):184,699
Last modified:May 5, 2009 - v2
Checksum:i93480B30076470DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti610A → S in BAC85501 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055278391R → G.2 PublicationsCorresponds to variant rs2488269dbSNPEnsembl.1
Natural variantiVAR_055279410V → L.Corresponds to variant rs11264498dbSNPEnsembl.1
Natural variantiVAR_055280645D → N.Corresponds to variant rs11264496dbSNPEnsembl.1
Natural variantiVAR_055281663R → C.2 PublicationsCorresponds to variant rs744224dbSNPEnsembl.1
Natural variantiVAR_055282770H → Y.Corresponds to variant rs1078890dbSNPEnsembl.1
Natural variantiVAR_0552831061Q → H.Corresponds to variant rs11804414dbSNPEnsembl.1
Natural variantiVAR_0552841097P → S.Corresponds to variant rs12562301dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY253300 mRNA. Translation: AAP06954.1.
AB105103 mRNA. Translation: BAC78211.1.
AL365181 Genomic DNA. Translation: CAI13046.1.
AK122653 mRNA. Translation: BAC85501.1.
CCDSiCCDS1144.1.
RefSeqiNP_839943.2. NM_178229.4.
UniGeneiHs.591495.

Genome annotation databases

EnsembliENST00000361170; ENSP00000354451; ENSG00000183856.
GeneIDi128239.
KEGGihsa:128239.
UCSCiuc001fpf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY253300 mRNA. Translation: AAP06954.1.
AB105103 mRNA. Translation: BAC78211.1.
AL365181 Genomic DNA. Translation: CAI13046.1.
AK122653 mRNA. Translation: BAC85501.1.
CCDSiCCDS1144.1.
RefSeqiNP_839943.2. NM_178229.4.
UniGeneiHs.591495.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ISUX-ray1.88A1529-1631[»]
ProteinModelPortaliQ86VI3.
SMRiQ86VI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126102. 27 interactors.
IntActiQ86VI3. 12 interactors.
MINTiMINT-8330040.
STRINGi9606.ENSP00000354451.

PTM databases

iPTMnetiQ86VI3.
PhosphoSitePlusiQ86VI3.

Polymorphism and mutation databases

BioMutaiIQGAP3.
DMDMi229462887.

Proteomic databases

EPDiQ86VI3.
MaxQBiQ86VI3.
PaxDbiQ86VI3.
PeptideAtlasiQ86VI3.
PRIDEiQ86VI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361170; ENSP00000354451; ENSG00000183856.
GeneIDi128239.
KEGGihsa:128239.
UCSCiuc001fpf.4. human.

Organism-specific databases

CTDi128239.
DisGeNETi128239.
GeneCardsiIQGAP3.
H-InvDBHIX0023560.
HGNCiHGNC:20669. IQGAP3.
HPAiHPA030142.
HPA030143.
neXtProtiNX_Q86VI3.
OpenTargetsiENSG00000183856.
PharmGKBiPA134954177.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2128. Eukaryota.
COG5261. LUCA.
GeneTreeiENSGT00600000084379.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
InParanoidiQ86VI3.
KOiK05767.
OMAiYRNGRGQ.
OrthoDBiEOG091G00ET.
PhylomeDBiQ86VI3.
TreeFamiTF313078.

Enzyme and pathway databases

BioCyciZFISH:G66-30690-MONOMER.
ReactomeiR-HSA-5626467. RHO GTPases activate IQGAPs.

Miscellaneous databases

ChiTaRSiIQGAP3. human.
EvolutionaryTraceiQ86VI3.
GenomeRNAii128239.
PROiQ86VI3.

Gene expression databases

BgeeiENSG00000183856.
CleanExiHS_IQGAP3.
ExpressionAtlasiQ86VI3. baseline and differential.
GenevisibleiQ86VI3. HS.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 4 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 4 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 4 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIQGA3_HUMAN
AccessioniPrimary (citable) accession number: Q86VI3
Secondary accession number(s): Q5T3H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.