Q86VI1 (EX3L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exocyst complex component 3-like protein

Alternative name(s):
Protein Jiangli

Gene names

Name:	EXOC3L1
Synonyms:	EXOC3L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	746 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	As part of the exocyst, may play a role in regulated exocytosis of insulin granules By similarity.
Subunit structure	Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle By similarity. Note: Colocalizes with insulin granules By similarity.
Sequence similarities	Belongs to the SEC6 family.

Ontologies

Keywords
Biological process	Exocytosis
Cellular component	Cytoplasmic vesicle
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from sequence or structural similarity PubMed 18480549. Source: UniProtKB peptide hormone secretion Inferred from sequence or structural similarity PubMed 18480549. Source: UniProtKB
Cellular_component	exocyst Inferred from sequence or structural similarity PubMed 18480549. Source: UniProtKB secretory granule Inferred from sequence or structural similarity PubMed 18480549. Source: UniProtKB transport vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 746	746	Exocyst complex component 3-like protein		PRO_0000309474
Regions
	Region	1 – 370	370	Mediates interaction with EXOC2, EXOC4 and EXOC5 By similarity
Natural variations
	Natural variant	75	1	Y → N in a breast cancer sample; somatic mutation. Ref.6		VAR_037002
	Natural variant	514	1	A → D in a breast cancer sample; somatic mutation. Ref.6		VAR_037003
	Natural variant	561	1	Q → E. Corresponds to variant rs9939768 [ dbSNP | Ensembl ].		VAR_036959
	Natural variant	634	1	S → G. Corresponds to variant rs16957212 [ dbSNP | Ensembl ].		VAR_036960
Experimental info
	Sequence conflict	187	1	V → F in BAB84916. Ref.5
	Sequence conflict	499	1	S → G in AAP12545. Ref.1
	Sequence conflict	499	1	S → G in BAB84916. Ref.5
	Sequence conflict	701 – 707	7	Missing in BAC03991. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q86VI1 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: C762DE3E63D782C9	FASTA	746	81,678
	10 20 30 40 50 60 MDSAAKDEMQ PALSPGPEWP EQERAEQLAR GAALKWASGI FYRPEQLARL GQYRSREVQR 70 80 90 100 110 120 TCSLESRLKS VMQSYLEGVQ TGVWQLAQAI EVVQGTREAL SQARGLLQGM SQALQTLEPL 130 140 150 160 170 180 RERVAQHKQL QALSHLLPRL RAVPAAVSHT QTLIDGQQFL EAYVSLRELE QLREDTWAPL 190 200 210 220 230 240 GGLELPVFQG LDLLFEALGQ AVEAAAGAAG KLAREDPALL VAAVRVAEVE TGRTTPLGQV 250 260 270 280 290 300 PRDWRQRCLR ALQEGLEQAH FGSPLLPAPG ALPGWLEALR VALPVELATA EALVAPCCPP 310 320 330 340 350 360 QYNVVQLWAH TLHSGLRRSL QNLLAGPELE AADAFALLHW ALHVYLGQEM MGSLELGPEA 370 380 390 400 410 420 DVSQLEPLLT LENIEQLEAT FVANIQASVS QWLQNALDGE VAEWGREHGP NTDPSGSYYS 430 440 450 460 470 480 PMPAIVLQIL EENIRVASLV SESLQQRVHG MALSELGTFL RSFSDALIRF SRDHFRGKSM 490 500 510 520 530 540 APHYVPYLLA ALNHKSALSS SVSVLQLDGA PSGALAPVEA ALDELQRRIY RLVLEALQAE 550 560 570 580 590 600 LQPLFADLPS RQWLSSPELL QSVCERTGRF CRDFWRVRNP TVQLLLAEAE RAVVLQYLSA 610 620 630 640 650 660 LMQGRLVCRG ADERTQAAER LRHDAAQLQQ LFLSLGLEEN AHCAPVLLAL RELLNLRDPA 670 680 690 700 710 720 LLGLEVAGLR QQFPDVSEDH VSALLGLRGD LSREQHLAAL SSLQAALPPS PRASRRVLFS 730 740 LVPAPALAPA SCLPSGSCAR ALLLAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of Jiangli gene." Shan Y.X., Jiang L., Yu L. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine and Spleen.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones." Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O. DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-746. Tissue: Spleen.
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-75 AND ASP-514.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY255669 mRNA. Translation: AAP12545.1. AK092858 mRNA. Translation: BAC03991.1. AK292004 mRNA. Translation: BAF84693.1. AC040160 Genomic DNA. No translation available. AC074143 Genomic DNA. No translation available. CH471092 Genomic DNA. Translation: EAW83092.1. AK074090 mRNA. Translation: BAB84916.1.
IPI	IPI00328904.
RefSeq	NP_848611.2. NM_178516.3.
UniGene	Hs.647356.
3D structure databases
ProteinModelPortal	Q86VI1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VI1. 1 interaction.
STRING	9606.ENSP00000325674.
PTM databases
PhosphoSite	Q86VI1.
Polymorphism databases
DMDM	223590205.
Proteomic databases
PaxDb	Q86VI1.
PRIDE	Q86VI1.
Protocols and materials databases
DNASU	283849.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314586; ENSP00000325674; ENSG00000179044.
GeneID	283849.
KEGG	hsa:283849.
UCSC	uc002erw.1. human.
Organism-specific databases
CTD	283849.
GeneCards	GC16M067219.
H-InvDB	HIX0079826.
HGNC	HGNC:27540. EXOC3L1.
HPA	HPA029574.
MIM	614117. gene.
neXtProt	NX_Q86VI1.
PharmGKB	PA147031724.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG329014.
HOVERGEN	HBG098199.
InParanoid	Q86VI1.
OMA	MQGRLVC.
OrthoDB	EOG4J6RQJ.
PhylomeDB	Q86VI1.
Gene expression databases
ArrayExpress	Q86VI1.
Bgee	Q86VI1.
CleanEx	HS_EXOC3L.
Genevestigator	Q86VI1.
Family and domain databases
InterPro	IPR010326. Sec6. [Graphical view]
PANTHER	PTHR21292. PTHR21292. 1 hit.
Pfam	PF06046. Sec6. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	283849.
NextBio	94285.
SOURCE	Search...

Entry information

Entry name

EX3L1_HUMAN

Accession

Primary (citable) accession number: Q86VI1
Secondary accession number(s): A8K7I9, Q8NAD2, Q8TEN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	February 10, 2009
Last modified:	April 3, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.