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Protein

Exocyst complex component 3-like protein

Gene

EXOC3L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

As part of the exocyst, may play a role in regulated exocytosis of insulin granules.By similarity

GO - Molecular functioni

GO - Biological processi

  • exocyst localization Source: GO_Central
  • exocytosis Source: UniProtKB
  • peptide hormone secretion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3-like protein
Alternative name(s):
Protein Jiangli
Gene namesi
Name:EXOC3L1
Synonyms:EXOC3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:27540. EXOC3L1.

Subcellular locationi

GO - Cellular componenti

  • exocyst Source: UniProtKB
  • secretory granule Source: UniProtKB
  • transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi283849.
OpenTargetsiENSG00000179044.
PharmGKBiPA147031724.

Polymorphism and mutation databases

BioMutaiEXOC3L1.
DMDMi223590205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094741 – 746Exocyst complex component 3-like proteinAdd BLAST746

Proteomic databases

PaxDbiQ86VI1.
PeptideAtlasiQ86VI1.
PRIDEiQ86VI1.

PTM databases

iPTMnetiQ86VI1.
PhosphoSitePlusiQ86VI1.

Expressioni

Gene expression databases

BgeeiENSG00000179044.
CleanExiHS_EXOC3L.
ExpressionAtlasiQ86VI1. baseline and differential.
GenevisibleiQ86VI1. HS.

Organism-specific databases

HPAiHPA029574.

Interactioni

Subunit structurei

Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ86VI1. 4 interactors.
STRINGi9606.ENSP00000325674.

Structurei

3D structure databases

ProteinModelPortaliQ86VI1.
SMRiQ86VI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 370Mediates interaction with EXOC2, EXOC4 and EXOC5By similarityAdd BLAST370

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOVERGENiHBG098199.
InParanoidiQ86VI1.
KOiK19987.
OMAiMQGRLVC.
OrthoDBiEOG091G02T2.
PhylomeDBiQ86VI1.
TreeFamiTF314979.

Family and domain databases

InterProiIPR010326. EXOC3/Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAAKDEMQ PALSPGPEWP EQERAEQLAR GAALKWASGI FYRPEQLARL
60 70 80 90 100
GQYRSREVQR TCSLESRLKS VMQSYLEGVQ TGVWQLAQAI EVVQGTREAL
110 120 130 140 150
SQARGLLQGM SQALQTLEPL RERVAQHKQL QALSHLLPRL RAVPAAVSHT
160 170 180 190 200
QTLIDGQQFL EAYVSLRELE QLREDTWAPL GGLELPVFQG LDLLFEALGQ
210 220 230 240 250
AVEAAAGAAG KLAREDPALL VAAVRVAEVE TGRTTPLGQV PRDWRQRCLR
260 270 280 290 300
ALQEGLEQAH FGSPLLPAPG ALPGWLEALR VALPVELATA EALVAPCCPP
310 320 330 340 350
QYNVVQLWAH TLHSGLRRSL QNLLAGPELE AADAFALLHW ALHVYLGQEM
360 370 380 390 400
MGSLELGPEA DVSQLEPLLT LENIEQLEAT FVANIQASVS QWLQNALDGE
410 420 430 440 450
VAEWGREHGP NTDPSGSYYS PMPAIVLQIL EENIRVASLV SESLQQRVHG
460 470 480 490 500
MALSELGTFL RSFSDALIRF SRDHFRGKSM APHYVPYLLA ALNHKSALSS
510 520 530 540 550
SVSVLQLDGA PSGALAPVEA ALDELQRRIY RLVLEALQAE LQPLFADLPS
560 570 580 590 600
RQWLSSPELL QSVCERTGRF CRDFWRVRNP TVQLLLAEAE RAVVLQYLSA
610 620 630 640 650
LMQGRLVCRG ADERTQAAER LRHDAAQLQQ LFLSLGLEEN AHCAPVLLAL
660 670 680 690 700
RELLNLRDPA LLGLEVAGLR QQFPDVSEDH VSALLGLRGD LSREQHLAAL
710 720 730 740
SSLQAALPPS PRASRRVLFS LVPAPALAPA SCLPSGSCAR ALLLAE
Length:746
Mass (Da):81,678
Last modified:February 10, 2009 - v2
Checksum:iC762DE3E63D782C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187V → F in BAB84916 (PubMed:12693554).Curated1
Sequence conflicti499S → G in AAP12545 (Ref. 1) Curated1
Sequence conflicti499S → G in BAB84916 (PubMed:12693554).Curated1
Sequence conflicti701 – 707Missing in BAC03991 (PubMed:14702039).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03700275Y → N in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs117403380dbSNPEnsembl.1
Natural variantiVAR_037003514A → D in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs142958191dbSNPEnsembl.1
Natural variantiVAR_036959561Q → E.Corresponds to variant rs9939768dbSNPEnsembl.1
Natural variantiVAR_036960634S → G.Corresponds to variant rs16957212dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY255669 mRNA. Translation: AAP12545.1.
AK092858 mRNA. Translation: BAC03991.1.
AK292004 mRNA. Translation: BAF84693.1.
AC040160 Genomic DNA. No translation available.
AC074143 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83092.1.
AK074090 mRNA. Translation: BAB84916.1.
CCDSiCCDS10832.1.
RefSeqiNP_848611.2. NM_178516.3.
UniGeneiHs.647356.

Genome annotation databases

EnsembliENST00000314586; ENSP00000325674; ENSG00000179044.
GeneIDi283849.
KEGGihsa:283849.
UCSCiuc002erx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY255669 mRNA. Translation: AAP12545.1.
AK092858 mRNA. Translation: BAC03991.1.
AK292004 mRNA. Translation: BAF84693.1.
AC040160 Genomic DNA. No translation available.
AC074143 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83092.1.
AK074090 mRNA. Translation: BAB84916.1.
CCDSiCCDS10832.1.
RefSeqiNP_848611.2. NM_178516.3.
UniGeneiHs.647356.

3D structure databases

ProteinModelPortaliQ86VI1.
SMRiQ86VI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86VI1. 4 interactors.
STRINGi9606.ENSP00000325674.

PTM databases

iPTMnetiQ86VI1.
PhosphoSitePlusiQ86VI1.

Polymorphism and mutation databases

BioMutaiEXOC3L1.
DMDMi223590205.

Proteomic databases

PaxDbiQ86VI1.
PeptideAtlasiQ86VI1.
PRIDEiQ86VI1.

Protocols and materials databases

DNASUi283849.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314586; ENSP00000325674; ENSG00000179044.
GeneIDi283849.
KEGGihsa:283849.
UCSCiuc002erx.1. human.

Organism-specific databases

CTDi283849.
DisGeNETi283849.
GeneCardsiEXOC3L1.
H-InvDBHIX0079826.
HGNCiHGNC:27540. EXOC3L1.
HPAiHPA029574.
MIMi614117. gene.
neXtProtiNX_Q86VI1.
OpenTargetsiENSG00000179044.
PharmGKBiPA147031724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOVERGENiHBG098199.
InParanoidiQ86VI1.
KOiK19987.
OMAiMQGRLVC.
OrthoDBiEOG091G02T2.
PhylomeDBiQ86VI1.
TreeFamiTF314979.

Miscellaneous databases

GeneWikiiEXOC3L.
GenomeRNAii283849.
PROiQ86VI1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179044.
CleanExiHS_EXOC3L.
ExpressionAtlasiQ86VI1. baseline and differential.
GenevisibleiQ86VI1. HS.

Family and domain databases

InterProiIPR010326. EXOC3/Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEX3L1_HUMAN
AccessioniPrimary (citable) accession number: Q86VI1
Secondary accession number(s): A8K7I9, Q8NAD2, Q8TEN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 10, 2009
Last modified: November 30, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.