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Protein

Leucine-rich repeat transmembrane neuronal protein 3

Gene

LRRTM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31264-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 3
Gene namesi
Name:LRRTM3
ORF Names:UNQ803/PRO1693
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:19410. LRRTM3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 419ExtracellularSequence analysisAdd BLAST389
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Topological domaini441 – 581CytoplasmicSequence analysisAdd BLAST141

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi347731.
OpenTargetsiENSG00000198739.
PharmGKBiPA134962991.

Polymorphism and mutation databases

BioMutaiLRRTM3.
DMDMi68052341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001835531 – 581Leucine-rich repeat transmembrane neuronal protein 3Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi357N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ86VH5.
PaxDbiQ86VH5.
PeptideAtlasiQ86VH5.
PRIDEiQ86VH5.

PTM databases

iPTMnetiQ86VH5.
PhosphoSitePlusiQ86VH5.

Expressioni

Tissue specificityi

Expressed in neuronal tissues.1 Publication

Gene expression databases

BgeeiENSG00000198739.
CleanExiHS_LRRTM3.

Organism-specific databases

HPAiHPA024109.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355187.

Structurei

3D structure databases

ProteinModelPortaliQ86VH5.
SMRiQ86VH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 61LRRNTAdd BLAST31
Repeati63 – 83LRR 1Add BLAST21
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 179LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Repeati206 – 226LRR 7Add BLAST21
Repeati230 – 251LRR 8Add BLAST22
Repeati254 – 275LRR 9Add BLAST22
Repeati279 – 300LRR 10Add BLAST22
Domaini312 – 363LRRCTAdd BLAST52

Sequence similaritiesi

Belongs to the LRRTM family.Curated
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ86VH5.
OMAiGPCTYSK.
OrthoDBiEOG091G03BI.
PhylomeDBiQ86VH5.
TreeFamiTF332659.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFNVIRLLS GSAVALVIAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ
60 70 80 90 100
KLQEIPSSIS AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI
110 120 130 140 150
DENAFNGIRR LKELILSSNR ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS
160 170 180 190 200
EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC RNLELLDLGY NRIRSLARNV
210 220 230 240 250
FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYLQWNK ISVIGQTMSW
260 270 280 290 300
TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS
310 320 330 340 350
WISLNDISLA GNIWECSRNI CSLVNWLKSF KGLRENTIIC ASPKELQGVN
360 370 380 390 400
VIDAVKNYSI CGKSTTERFD LARALPKPTF KPKLPRPKHE SKPPLPPTVG
410 420 430 440 450
ATEPGPETDA DAEHISFHKI IAGSVALFLS VLVILLVIYV SWKRYPASMK
460 470 480 490 500
QLQQRSLMRR HRKKKRQSLK QMTPSTQEFY VDYKPTNTET SEMLLNGTGP
510 520 530 540 550
CTYNKSGSRE CEIPLSMNVS TFLAYDQPTI SYCGVHHELL SHKSFETNAQ
560 570 580
EDTMETHLET ELDLSTITTA GRISDHKQQL A
Length:581
Mass (Da):65,896
Last modified:June 21, 2005 - v2
Checksum:iA025CF13AA663730
GO
Isoform 2 (identifier: Q86VH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: I → V
     514-581: Missing.

Show »
Length:513
Mass (Da):58,267
Checksum:i9D909E8F917A26F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266E → G in CAE45717 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014189513I → V in isoform 2. 2 Publications1
Alternative sequenceiVSP_014190514 – 581Missing in isoform 2. 2 PublicationsAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182028 mRNA. Translation: AAO67549.1.
AY358315 mRNA. Translation: AAQ88681.1.
AK290168 mRNA. Translation: BAF82857.1.
BX640611 mRNA. Translation: CAE45717.1.
BC111492 mRNA. Translation: AAI11493.1.
BC113715 mRNA. Translation: AAI13716.1.
BC113717 mRNA. Translation: AAI13718.1.
CCDSiCCDS7270.1. [Q86VH5-1]
RefSeqiNP_821079.3. NM_178011.4. [Q86VH5-1]
UniGeneiHs.652155.
Hs.712279.

Genome annotation databases

EnsembliENST00000361320; ENSP00000355187; ENSG00000198739. [Q86VH5-1]
GeneIDi347731.
KEGGihsa:347731.
UCSCiuc001jmz.2. human. [Q86VH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182028 mRNA. Translation: AAO67549.1.
AY358315 mRNA. Translation: AAQ88681.1.
AK290168 mRNA. Translation: BAF82857.1.
BX640611 mRNA. Translation: CAE45717.1.
BC111492 mRNA. Translation: AAI11493.1.
BC113715 mRNA. Translation: AAI13716.1.
BC113717 mRNA. Translation: AAI13718.1.
CCDSiCCDS7270.1. [Q86VH5-1]
RefSeqiNP_821079.3. NM_178011.4. [Q86VH5-1]
UniGeneiHs.652155.
Hs.712279.

3D structure databases

ProteinModelPortaliQ86VH5.
SMRiQ86VH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355187.

PTM databases

iPTMnetiQ86VH5.
PhosphoSitePlusiQ86VH5.

Polymorphism and mutation databases

BioMutaiLRRTM3.
DMDMi68052341.

Proteomic databases

MaxQBiQ86VH5.
PaxDbiQ86VH5.
PeptideAtlasiQ86VH5.
PRIDEiQ86VH5.

Protocols and materials databases

DNASUi347731.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361320; ENSP00000355187; ENSG00000198739. [Q86VH5-1]
GeneIDi347731.
KEGGihsa:347731.
UCSCiuc001jmz.2. human. [Q86VH5-1]

Organism-specific databases

CTDi347731.
DisGeNETi347731.
GeneCardsiLRRTM3.
HGNCiHGNC:19410. LRRTM3.
HPAiHPA024109.
MIMi610869. gene.
neXtProtiNX_Q86VH5.
OpenTargetsiENSG00000198739.
PharmGKBiPA134962991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ86VH5.
OMAiGPCTYSK.
OrthoDBiEOG091G03BI.
PhylomeDBiQ86VH5.
TreeFamiTF332659.

Enzyme and pathway databases

BioCyciZFISH:G66-31264-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

GenomeRNAii347731.
PROiQ86VH5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198739.
CleanExiHS_LRRTM3.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRT3_HUMAN
AccessioniPrimary (citable) accession number: Q86VH5
Secondary accession number(s): A8K2A3, Q2NKX7, Q6N0A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.