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Q86VH2 (KIF27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF27
Gene names
Name:KIF27
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1401 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an essential role in motile ciliogenesis By similarity.

Subunit structure

Interacts with STK36 By similarity.

Subcellular location

Cytoplasmcytoskeleton Probable. Cell projectioncilium By similarity. Note: Localizes to centrioles and basal bodies By similarity.

Tissue specificity

Testis, pancreatic islet, germ cell tumors and Jurkat T-cells.

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.

Contains 1 kinesin motor domain.

Sequence caution

The sequence CAB63770.1 differs from that shown. Reason: Frameshift at position 728.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86VH2-1)

Also known as: KIF27A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86VH2-2)

Also known as: KIF27B;

The sequence of this isoform differs from the canonical sequence as follows:
     816-881: Missing.
Isoform 3 (identifier: Q86VH2-3)

Also known as: KIF27C;

The sequence of this isoform differs from the canonical sequence as follows:
     882-978: Missing.
Isoform 4 (identifier: Q86VH2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-609: Missing.
     882-896: EIQLKTGQEEGLKPK → VILSYIPAKYNMKC
     897-1401: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14011401Kinesin-like protein KIF27
PRO_0000307143

Regions

Domain5 – 341337Kinesin motor
Nucleotide binding84 – 918ATP By similarity
Coiled coil352 – 41362 Potential
Coiled coil489 – 55769 Potential
Coiled coil705 – 886182 Potential
Coiled coil916 – 1070155 Potential
Coiled coil1118 – 115437 Potential
Coiled coil1190 – 121930 Potential

Natural variations

Alternative sequence1 – 609609Missing in isoform 4.
VSP_028602
Alternative sequence816 – 88166Missing in isoform 2.
VSP_028603
Alternative sequence882 – 97897Missing in isoform 3.
VSP_028604
Alternative sequence882 – 89615EIQLK…GLKPK → VILSYIPAKYNMKC in isoform 4.
VSP_028605
Alternative sequence897 – 1401505Missing in isoform 4.
VSP_028606
Natural variant2131I → V.
Corresponds to variant rs12001918 [ dbSNP | Ensembl ].
VAR_035361
Natural variant3001R → Q.
Corresponds to variant rs35594736 [ dbSNP | Ensembl ].
VAR_035362
Natural variant10361N → D. Ref.4
Corresponds to variant rs55654273 [ dbSNP | Ensembl ].
VAR_061286

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (KIF27A) [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 4563BA414C30DB21

FASTA1,401160,283
        10         20         30         40         50         60 
MEEIPVKVAV RIRPLLCKEA LHNHQVCVRV IPNSQQVIIG RDRVFTFDFV FGKNSTQDEV 

        70         80         90        100        110        120 
YNTCIKPLVL SLIEGYNATV FAYGQTGSGK TYTIGGGHIA SVVEGQKGII PRAIQEIFQS 

       130        140        150        160        170        180 
ISEHPSIDFN VKVSYIEVYK EDLRDLLELE TSMKDLHIRE DEKGNTVIVG AKECHVESAG 

       190        200        210        220        230        240 
EVMSLLEMGN AARHTGTTQM NEHSSRSHAI FTISICQVHK NMEAAEDGSW YSPRHIVSKF 

       250        260        270        280        290        300 
HFVDLAGSER VTKTGNTGER FKESIQINSG LLALGNVISA LGDPRRKSSH IPYRDAKITR 

       310        320        330        340        350        360 
LLKDSLGGSA KTVMITCVSP SSSNFDESLN SLKYANRARN IRNKPTVNFS PESDRIDEME 

       370        380        390        400        410        420 
FEIKLLREAL QSQQAGVSQT TQINREGSPD TNRIHSLEEQ VAQLQGECLG YQCCVEEAFT 

       430        440        450        460        470        480 
FLVDLKDTVR LNEKQQHKLQ EWFNMIQEVR KAVLTSFRGI GGTASLEEGP QHVTVLQLKR 

       490        500        510        520        530        540 
ELKKCQCVLA ADEVVFNQKE LEVKELKNQV QMMVQENKGH AVSLKEAQKV NRLQNEKIIE 

       550        560        570        580        590        600 
QQLLVDQLSE ELTKLNLSVT SSAKENCGDG PDARIPERRP YTVPFDTHLG HYIYIPSRQD 

       610        620        630        640        650        660 
SRKVHTSPPM YSLDRIFAGF RTRSQMLLGH IEEQDKVLHC QFSDNSDDEE SEGQEKSGTR 

       670        680        690        700        710        720 
CRSRSWIQKP DSVCSLVELS DTQDETQKSD LENEDLKIDC LQESQELNLQ KLKNSERILT 

       730        740        750        760        770        780 
EAKQKMRELT INIKMKEDLI KELIKTGNDA KSVSKQYSLK VTKLEHDAEQ AKVELIETQK 

       790        800        810        820        830        840 
QLQELENKDL SDVAMKVKLQ KEFRKKMDAA KLRVQVLQKK QQDSKKLASL SIQNEKRANE 

       850        860        870        880        890        900 
LEQSVDHMKY QKIQLQRKLR EENEKRKQLD AVIKRDQQKI KEIQLKTGQE EGLKPKAEDL 

       910        920        930        940        950        960 
DACNLKRRKG SFGSIDHLQK LDEQKKWLDE EVEKVLNQRQ ELEELEADLK KREAIVSKKE 

       970        980        990       1000       1010       1020 
ALLQEKSHLE NKKLRSSQAL NTDSLKISTR LNLLEQELSE KNVQLQTSTA EEKTKISEQV 

      1030       1040       1050       1060       1070       1080 
EVLQKEKDQL QKRRHNVDEK LKNGRVLSPE EEHVLFQLEE GIEALEAAIE YRNESIQNRQ 

      1090       1100       1110       1120       1130       1140 
KSLRASFHNL SRGEANVLEK LACLSPVEIR TILFRYFNKV VNLREAERKQ QLYNEEMKMK 

      1150       1160       1170       1180       1190       1200 
VLERDNMVRE LESALDHLKL QCDRRLTLQQ KEHEQKMQLL LHHFKEQDGE GIMETFKTYE 

      1210       1220       1230       1240       1250       1260 
DKIQQLEKDL YFYKKTSRDH KKKLKELVGE AIRRQLAPSE YQEAGDGVLK PEGGGMLSEE 

      1270       1280       1290       1300       1310       1320 
LKWASRPESM KLSGREREMD SSASSLRTQP NPQKLWEDIP ELPPIHSSLA PPSGHMLGNE 

      1330       1340       1350       1360       1370       1380 
NKTETDDNQF TKSHSRLSSQ IQVVGNVGRL HGVTPVKLCR KELRQISALE LSLRRSSLGV 

      1390       1400 
GIGSMAADSI EVSRKPRDLK T 

« Hide

Isoform 2 (KIF27B) [UniParc].

Checksum: D3D02A926D9E823F
Show »

FASTA1,335152,314
Isoform 3 (KIF27C) [UniParc].

Checksum: 7FEBD1BBC879016C
Show »

FASTA1,304148,978
Isoform 4 [UniParc].

Checksum: D68AE60C142EC48B
Show »

FASTA28633,547

References

« Hide 'large scale' references
[1]"Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 4).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 569-1401 (ISOFORM 1), VARIANT ASP-1036.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY237536 mRNA. Translation: AAP04413.1.
AY237537 mRNA. Translation: AAP04414.1.
AY237538 mRNA. Translation: AAP04415.1.
AL354733 Genomic DNA. Translation: CAI16012.1.
AL354733 Genomic DNA. Translation: CAI16013.1.
BC140788 mRNA. Translation: AAI40789.1.
AL133654 mRNA. Translation: CAB63770.1. Frameshift.
CCDSCCDS65071.1. [Q86VH2-2]
CCDS65072.1. [Q86VH2-3]
CCDS6665.1. [Q86VH2-1]
PIRT43446.
RefSeqNP_001258856.1. NM_001271927.1. [Q86VH2-2]
NP_001258857.1. NM_001271928.1. [Q86VH2-3]
NP_060046.1. NM_017576.2. [Q86VH2-1]
XP_006717239.1. XM_006717176.1. [Q86VH2-1]
UniGeneHs.697514.

3D structure databases

ProteinModelPortalQ86VH2.
SMRQ86VH2. Positions 2-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120730. 1 interaction.
IntActQ86VH2. 1 interaction.
MINTMINT-7944150.
STRING9606.ENSP00000297814.

PTM databases

PhosphoSiteQ86VH2.

Polymorphism databases

DMDM74750464.

Proteomic databases

MaxQBQ86VH2.
PaxDbQ86VH2.
PRIDEQ86VH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297814; ENSP00000297814; ENSG00000165115. [Q86VH2-1]
ENST00000334204; ENSP00000333928; ENSG00000165115. [Q86VH2-3]
ENST00000376347; ENSP00000365525; ENSG00000165115. [Q86VH2-4]
ENST00000413982; ENSP00000401688; ENSG00000165115. [Q86VH2-2]
GeneID55582.
KEGGhsa:55582.
UCSCuc004ana.4. human. [Q86VH2-1]
uc010mpw.4. human. [Q86VH2-2]
uc010mpx.4. human. [Q86VH2-3]

Organism-specific databases

CTD55582.
GeneCardsGC09M086451.
HGNCHGNC:18632. KIF27.
HPAHPA022246.
MIM611253. gene.
neXtProtNX_Q86VH2.
PharmGKBPA134912901.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5059.
HOGENOMHOG000068072.
HOVERGENHBG054858.
InParanoidQ86VH2.
KOK10395.
OMASPEEEHV.
OrthoDBEOG7K3TK3.
PhylomeDBQ86VH2.
TreeFamTF325946.

Gene expression databases

ArrayExpressQ86VH2.
BgeeQ86VH2.
CleanExHS_KIF27.
GenevestigatorQ86VH2.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi55582.
NextBio60090.
PROQ86VH2.
SOURCESearch...

Entry information

Entry nameKIF27_HUMAN
AccessionPrimary (citable) accession number: Q86VH2
Secondary accession number(s): B2RTR8 expand/collapse secondary AC list , Q5T6W0, Q86VH0, Q86VH1, Q9UF54
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM