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Q86VH2

- KIF27_HUMAN

UniProt

Q86VH2 - KIF27_HUMAN

Protein

Kinesin-like protein KIF27

Gene

KIF27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Plays an essential role in motile ciliogenesis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi84 – 918ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: InterPro

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. epithelial cilium movement Source: Ensembl
    3. ventricular system development Source: Ensembl

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF27
    Gene namesi
    Name:KIF27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18632. KIF27.

    Subcellular locationi

    Cytoplasmcytoskeleton Curated. Cell projectioncilium By similarity
    Note: Localizes to centrioles and basal bodies.By similarity

    GO - Cellular componenti

    1. cilium Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW
    3. extracellular vesicular exosome Source: UniProt
    4. kinesin complex Source: InterPro
    5. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134912901.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14011401Kinesin-like protein KIF27PRO_0000307143Add
    BLAST

    Proteomic databases

    MaxQBiQ86VH2.
    PaxDbiQ86VH2.
    PRIDEiQ86VH2.

    PTM databases

    PhosphoSiteiQ86VH2.

    Expressioni

    Tissue specificityi

    Testis, pancreatic islet, germ cell tumors and Jurkat T-cells.

    Gene expression databases

    ArrayExpressiQ86VH2.
    BgeeiQ86VH2.
    CleanExiHS_KIF27.
    GenevestigatoriQ86VH2.

    Organism-specific databases

    HPAiHPA022246.

    Interactioni

    Subunit structurei

    Interacts with STK36.By similarity

    Protein-protein interaction databases

    BioGridi120730. 1 interaction.
    IntActiQ86VH2. 1 interaction.
    MINTiMINT-7944150.
    STRINGi9606.ENSP00000297814.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VH2.
    SMRiQ86VH2. Positions 2-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 341337Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili352 – 41362Sequence AnalysisAdd
    BLAST
    Coiled coili489 – 55769Sequence AnalysisAdd
    BLAST
    Coiled coili705 – 886182Sequence AnalysisAdd
    BLAST
    Coiled coili916 – 1070155Sequence AnalysisAdd
    BLAST
    Coiled coili1118 – 115437Sequence AnalysisAdd
    BLAST
    Coiled coili1190 – 121930Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOGENOMiHOG000068072.
    HOVERGENiHBG054858.
    InParanoidiQ86VH2.
    KOiK10395.
    OMAiSPEEEHV.
    OrthoDBiEOG7K3TK3.
    PhylomeDBiQ86VH2.
    TreeFamiTF325946.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86VH2-1) [UniParc]FASTAAdd to Basket

    Also known as: KIF27A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEIPVKVAV RIRPLLCKEA LHNHQVCVRV IPNSQQVIIG RDRVFTFDFV     50
    FGKNSTQDEV YNTCIKPLVL SLIEGYNATV FAYGQTGSGK TYTIGGGHIA 100
    SVVEGQKGII PRAIQEIFQS ISEHPSIDFN VKVSYIEVYK EDLRDLLELE 150
    TSMKDLHIRE DEKGNTVIVG AKECHVESAG EVMSLLEMGN AARHTGTTQM 200
    NEHSSRSHAI FTISICQVHK NMEAAEDGSW YSPRHIVSKF HFVDLAGSER 250
    VTKTGNTGER FKESIQINSG LLALGNVISA LGDPRRKSSH IPYRDAKITR 300
    LLKDSLGGSA KTVMITCVSP SSSNFDESLN SLKYANRARN IRNKPTVNFS 350
    PESDRIDEME FEIKLLREAL QSQQAGVSQT TQINREGSPD TNRIHSLEEQ 400
    VAQLQGECLG YQCCVEEAFT FLVDLKDTVR LNEKQQHKLQ EWFNMIQEVR 450
    KAVLTSFRGI GGTASLEEGP QHVTVLQLKR ELKKCQCVLA ADEVVFNQKE 500
    LEVKELKNQV QMMVQENKGH AVSLKEAQKV NRLQNEKIIE QQLLVDQLSE 550
    ELTKLNLSVT SSAKENCGDG PDARIPERRP YTVPFDTHLG HYIYIPSRQD 600
    SRKVHTSPPM YSLDRIFAGF RTRSQMLLGH IEEQDKVLHC QFSDNSDDEE 650
    SEGQEKSGTR CRSRSWIQKP DSVCSLVELS DTQDETQKSD LENEDLKIDC 700
    LQESQELNLQ KLKNSERILT EAKQKMRELT INIKMKEDLI KELIKTGNDA 750
    KSVSKQYSLK VTKLEHDAEQ AKVELIETQK QLQELENKDL SDVAMKVKLQ 800
    KEFRKKMDAA KLRVQVLQKK QQDSKKLASL SIQNEKRANE LEQSVDHMKY 850
    QKIQLQRKLR EENEKRKQLD AVIKRDQQKI KEIQLKTGQE EGLKPKAEDL 900
    DACNLKRRKG SFGSIDHLQK LDEQKKWLDE EVEKVLNQRQ ELEELEADLK 950
    KREAIVSKKE ALLQEKSHLE NKKLRSSQAL NTDSLKISTR LNLLEQELSE 1000
    KNVQLQTSTA EEKTKISEQV EVLQKEKDQL QKRRHNVDEK LKNGRVLSPE 1050
    EEHVLFQLEE GIEALEAAIE YRNESIQNRQ KSLRASFHNL SRGEANVLEK 1100
    LACLSPVEIR TILFRYFNKV VNLREAERKQ QLYNEEMKMK VLERDNMVRE 1150
    LESALDHLKL QCDRRLTLQQ KEHEQKMQLL LHHFKEQDGE GIMETFKTYE 1200
    DKIQQLEKDL YFYKKTSRDH KKKLKELVGE AIRRQLAPSE YQEAGDGVLK 1250
    PEGGGMLSEE LKWASRPESM KLSGREREMD SSASSLRTQP NPQKLWEDIP 1300
    ELPPIHSSLA PPSGHMLGNE NKTETDDNQF TKSHSRLSSQ IQVVGNVGRL 1350
    HGVTPVKLCR KELRQISALE LSLRRSSLGV GIGSMAADSI EVSRKPRDLK 1400
    T 1401
    Length:1,401
    Mass (Da):160,283
    Last modified:June 1, 2003 - v1
    Checksum:i4563BA414C30DB21
    GO
    Isoform 2 (identifier: Q86VH2-2) [UniParc]FASTAAdd to Basket

    Also known as: KIF27B

    The sequence of this isoform differs from the canonical sequence as follows:
         816-881: Missing.

    Show »
    Length:1,335
    Mass (Da):152,314
    Checksum:iD3D02A926D9E823F
    GO
    Isoform 3 (identifier: Q86VH2-3) [UniParc]FASTAAdd to Basket

    Also known as: KIF27C

    The sequence of this isoform differs from the canonical sequence as follows:
         882-978: Missing.

    Show »
    Length:1,304
    Mass (Da):148,978
    Checksum:i7FEBD1BBC879016C
    GO
    Isoform 4 (identifier: Q86VH2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-609: Missing.
         882-896: EIQLKTGQEEGLKPK → VILSYIPAKYNMKC
         897-1401: Missing.

    Show »
    Length:286
    Mass (Da):33,547
    Checksum:iD68AE60C142EC48B
    GO

    Sequence cautioni

    The sequence CAB63770.1 differs from that shown. Reason: Frameshift at position 728.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti213 – 2131I → V.
    Corresponds to variant rs12001918 [ dbSNP | Ensembl ].
    VAR_035361
    Natural varianti300 – 3001R → Q.
    Corresponds to variant rs35594736 [ dbSNP | Ensembl ].
    VAR_035362
    Natural varianti1036 – 10361N → D.1 Publication
    Corresponds to variant rs55654273 [ dbSNP | Ensembl ].
    VAR_061286

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 609609Missing in isoform 4. CuratedVSP_028602Add
    BLAST
    Alternative sequencei816 – 88166Missing in isoform 2. 1 PublicationVSP_028603Add
    BLAST
    Alternative sequencei882 – 97897Missing in isoform 3. 1 PublicationVSP_028604Add
    BLAST
    Alternative sequencei882 – 89615EIQLK…GLKPK → VILSYIPAKYNMKC in isoform 4. CuratedVSP_028605Add
    BLAST
    Alternative sequencei897 – 1401505Missing in isoform 4. CuratedVSP_028606Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY237536 mRNA. Translation: AAP04413.1.
    AY237537 mRNA. Translation: AAP04414.1.
    AY237538 mRNA. Translation: AAP04415.1.
    AL354733 Genomic DNA. Translation: CAI16012.1.
    AL354733 Genomic DNA. Translation: CAI16013.1.
    BC140788 mRNA. Translation: AAI40789.1.
    AL133654 mRNA. Translation: CAB63770.1. Frameshift.
    CCDSiCCDS65071.1. [Q86VH2-2]
    CCDS65072.1. [Q86VH2-3]
    CCDS6665.1. [Q86VH2-1]
    PIRiT43446.
    RefSeqiNP_001258856.1. NM_001271927.1. [Q86VH2-2]
    NP_001258857.1. NM_001271928.1. [Q86VH2-3]
    NP_060046.1. NM_017576.2. [Q86VH2-1]
    XP_006717239.1. XM_006717176.1. [Q86VH2-1]
    UniGeneiHs.697514.

    Genome annotation databases

    EnsembliENST00000297814; ENSP00000297814; ENSG00000165115. [Q86VH2-1]
    ENST00000334204; ENSP00000333928; ENSG00000165115. [Q86VH2-3]
    ENST00000376347; ENSP00000365525; ENSG00000165115. [Q86VH2-4]
    ENST00000413982; ENSP00000401688; ENSG00000165115. [Q86VH2-2]
    GeneIDi55582.
    KEGGihsa:55582.
    UCSCiuc004ana.4. human. [Q86VH2-1]
    uc010mpw.4. human. [Q86VH2-2]
    uc010mpx.4. human. [Q86VH2-3]

    Polymorphism databases

    DMDMi74750464.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY237536 mRNA. Translation: AAP04413.1 .
    AY237537 mRNA. Translation: AAP04414.1 .
    AY237538 mRNA. Translation: AAP04415.1 .
    AL354733 Genomic DNA. Translation: CAI16012.1 .
    AL354733 Genomic DNA. Translation: CAI16013.1 .
    BC140788 mRNA. Translation: AAI40789.1 .
    AL133654 mRNA. Translation: CAB63770.1 . Frameshift.
    CCDSi CCDS65071.1. [Q86VH2-2 ]
    CCDS65072.1. [Q86VH2-3 ]
    CCDS6665.1. [Q86VH2-1 ]
    PIRi T43446.
    RefSeqi NP_001258856.1. NM_001271927.1. [Q86VH2-2 ]
    NP_001258857.1. NM_001271928.1. [Q86VH2-3 ]
    NP_060046.1. NM_017576.2. [Q86VH2-1 ]
    XP_006717239.1. XM_006717176.1. [Q86VH2-1 ]
    UniGenei Hs.697514.

    3D structure databases

    ProteinModelPortali Q86VH2.
    SMRi Q86VH2. Positions 2-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120730. 1 interaction.
    IntActi Q86VH2. 1 interaction.
    MINTi MINT-7944150.
    STRINGi 9606.ENSP00000297814.

    PTM databases

    PhosphoSitei Q86VH2.

    Polymorphism databases

    DMDMi 74750464.

    Proteomic databases

    MaxQBi Q86VH2.
    PaxDbi Q86VH2.
    PRIDEi Q86VH2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297814 ; ENSP00000297814 ; ENSG00000165115 . [Q86VH2-1 ]
    ENST00000334204 ; ENSP00000333928 ; ENSG00000165115 . [Q86VH2-3 ]
    ENST00000376347 ; ENSP00000365525 ; ENSG00000165115 . [Q86VH2-4 ]
    ENST00000413982 ; ENSP00000401688 ; ENSG00000165115 . [Q86VH2-2 ]
    GeneIDi 55582.
    KEGGi hsa:55582.
    UCSCi uc004ana.4. human. [Q86VH2-1 ]
    uc010mpw.4. human. [Q86VH2-2 ]
    uc010mpx.4. human. [Q86VH2-3 ]

    Organism-specific databases

    CTDi 55582.
    GeneCardsi GC09M086451.
    HGNCi HGNC:18632. KIF27.
    HPAi HPA022246.
    MIMi 611253. gene.
    neXtProti NX_Q86VH2.
    PharmGKBi PA134912901.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOGENOMi HOG000068072.
    HOVERGENi HBG054858.
    InParanoidi Q86VH2.
    KOi K10395.
    OMAi SPEEEHV.
    OrthoDBi EOG7K3TK3.
    PhylomeDBi Q86VH2.
    TreeFami TF325946.

    Miscellaneous databases

    GenomeRNAii 55582.
    NextBioi 60090.
    PROi Q86VH2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86VH2.
    Bgeei Q86VH2.
    CleanExi HS_KIF27.
    Genevestigatori Q86VH2.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
      Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
      BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 4).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 569-1401 (ISOFORM 1), VARIANT ASP-1036.
      Tissue: Testis.

    Entry informationi

    Entry nameiKIF27_HUMAN
    AccessioniPrimary (citable) accession number: Q86VH2
    Secondary accession number(s): B2RTR8
    , Q5T6W0, Q86VH0, Q86VH1, Q9UF54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3