Q86VH2 (KIF27_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 78.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Kinesin-like protein KIF27 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Reference proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 1401 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Plays an essential role in motile ciliogenesis By similarity. |
| Subunit structure | Interacts with STK36 By similarity. |
| Subcellular location | Cytoplasm › cytoskeleton Probable. Cell projection › cilium By similarity. Note: Localizes to centrioles and basal bodies By similarity. |
| Tissue specificity | Testis, pancreatic islet, germ cell tumors and Jurkat T-cells. |
| Sequence similarities | Belongs to the kinesin-like protein family. KIF27 subfamily. Contains 1 kinesin-motor domain. |
| Sequence caution | The sequence CAB63770.1 differs from that shown. Reason: Frameshift at position 728. |
Ontologies
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q86VH2-1) Also known as: KIF27A; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q86VH2-2) Also known as: KIF27B; The sequence of this isoform differs from the canonical sequence as follows: 816-881: Missing. | ||||||
| Isoform 3 (identifier: Q86VH2-3) Also known as: KIF27C; The sequence of this isoform differs from the canonical sequence as follows: 882-978: Missing. | ||||||
| Isoform 4 (identifier: Q86VH2-4) The sequence of this isoform differs from the canonical sequence as follows: 1-609: Missing. 882-896: EIQLKTGQEEGLKPK → VILSYIPAKYNMKC 897-1401: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1401 | 1401 | Kinesin-like protein KIF27 | PRO_0000307143 | |||||
Regions | |||||||||
| Domain | 1 – 269 | 269 | Kinesin-motor | ||||||
| Nucleotide binding | 84 – 91 | 8 | ATP Potential | ||||||
| Coiled coil | 352 – 413 | 62 | Potential | ||||||
| Coiled coil | 489 – 557 | 69 | Potential | ||||||
| Coiled coil | 705 – 886 | 182 | Potential | ||||||
| Coiled coil | 916 – 1070 | 155 | Potential | ||||||
| Coiled coil | 1118 – 1154 | 37 | Potential | ||||||
| Coiled coil | 1190 – 1219 | 30 | Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 609 | 609 | Missing in isoform 4. | VSP_028602 | |||||
| Alternative sequence | 816 – 881 | 66 | Missing in isoform 2. | VSP_028603 | |||||
| Alternative sequence | 882 – 978 | 97 | Missing in isoform 3. | VSP_028604 | |||||
| Alternative sequence | 882 – 896 | 15 | EIQLK…GLKPK → VILSYIPAKYNMKC in isoform 4. | VSP_028605 | |||||
| Alternative sequence | 897 – 1401 | 505 | Missing in isoform 4. | VSP_028606 | |||||
| Natural variant | 213 | 1 | I → V. Corresponds to variant rs12001918 [ dbSNP | Ensembl ]. | VAR_035361 | |||||
| Natural variant | 300 | 1 | R → Q. Corresponds to variant rs35594736 [ dbSNP | Ensembl ]. | VAR_035362 | |||||
| Natural variant | 1036 | 1 | N → D. Ref.4 Corresponds to variant rs55654273 [ dbSNP | Ensembl ]. | VAR_061286 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs." Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C. BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). |
| [2] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 4). |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [4] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 569-1401 (ISOFORM 1), VARIANT ASP-1036. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY237536 mRNA. Translation: AAP04413.1. AY237537 mRNA. Translation: AAP04414.1. AY237538 mRNA. Translation: AAP04415.1. AL354733 Genomic DNA. Translation: CAI16012.1. AL354733 Genomic DNA. Translation: CAI16013.1. BC140788 mRNA. Translation: AAI40789.1. AL133654 mRNA. Translation: CAB63770.1. Frameshift. |
| IPI | IPI00294749. IPI00384317. IPI00869120. IPI00869282. |
| PIR | T43446. |
| RefSeq | NP_001258856.1. NM_001271927.1. NP_001258857.1. NM_001271928.1. NP_060046.1. NM_017576.2. |
| UniGene | Hs.697514. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1T5C based on UniProtKB Q02224. |
| ProteinModelPortal | Q86VH2. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9606.ENSP00000297814. |
PTM databases | |
| PhosphoSite | Q86VH2. |
Polymorphism databases | |
| DMDM | 74750464. |
Proteomic databases | |
| PaxDb | Q86VH2. |
| PRIDE | Q86VH2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000297814; ENSP00000297814; ENSG00000165115. ENST00000334204; ENSP00000333928; ENSG00000165115. ENST00000376347; ENSP00000365525; ENSG00000165115. ENST00000413982; ENSP00000401688; ENSG00000165115. |
| GeneID | 55582. |
| KEGG | hsa:55582. |
| UCSC | uc004ana.3. human. uc010mpw.3. human. uc010mpx.3. human. |
Organism-specific databases | |
| CTD | 55582. |
| GeneCards | GC09M086451. |
| HGNC | HGNC:18632. KIF27. |
| HPA | HPA022246. |
| MIM | 611253. gene. |
| neXtProt | NX_Q86VH2. |
| PharmGKB | PA134912901. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | COG5059. |
| HOGENOM | HOG000068072. |
| HOVERGEN | HBG054858. |
| InParanoid | Q86VH2. |
| KO | K10395. |
| OMA | NQFTKSH. |
| OrthoDB | EOG4CG07C. |
| PhylomeDB | Q86VH2. |
Gene expression databases | |
| ArrayExpress | Q86VH2. |
| Bgee | Q86VH2. |
| CleanEx | HS_KIF27. |
| Genevestigator | Q86VH2. |
Family and domain databases | |
| Gene3D | 3.40.850.10. 1 hit. |
| InterPro | IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view] |
| Pfam | PF00225. Kinesin. 1 hit. [Graphical view] |
| PRINTS | PR00380. KINESINHEAVY. |
| SMART | SM00129. KISc. 1 hit. [Graphical view] |
| PROSITE | PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 55582. |
| NextBio | 60090. |
| SOURCE | Search... |
Entry information
| Entry name | KIF27_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q86VH2 Secondary accession number(s): B2RTR8 Q9UF54 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
