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Protein

Kinesin-like protein KIF27

Gene

KIF27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in motile ciliogenesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 918ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: GO_Central
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: GO_Central

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. epithelial cilium movement Source: Ensembl
  3. metabolic process Source: GOC
  4. microtubule-based movement Source: GO_Central
  5. smoothened signaling pathway Source: GO_Central
  6. ventricular system development Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF27
Gene namesi
Name:KIF27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18632. KIF27.

Subcellular locationi

Cytoplasmcytoskeleton Curated. Cell projectioncilium By similarity
Note: Localizes to centrioles and basal bodies.By similarity

GO - Cellular componenti

  1. cilium Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: UniProtKB
  4. kinesin complex Source: GO_Central
  5. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134912901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14011401Kinesin-like protein KIF27PRO_0000307143Add
BLAST

Proteomic databases

MaxQBiQ86VH2.
PaxDbiQ86VH2.
PRIDEiQ86VH2.

PTM databases

PhosphoSiteiQ86VH2.

Expressioni

Tissue specificityi

Testis, pancreatic islet, germ cell tumors and Jurkat T-cells.

Gene expression databases

BgeeiQ86VH2.
CleanExiHS_KIF27.
ExpressionAtlasiQ86VH2. baseline and differential.
GenevestigatoriQ86VH2.

Organism-specific databases

HPAiHPA022246.

Interactioni

Subunit structurei

Interacts with STK36.By similarity

Protein-protein interaction databases

BioGridi120730. 1 interaction.
IntActiQ86VH2. 1 interaction.
MINTiMINT-7944150.
STRINGi9606.ENSP00000297814.

Structurei

3D structure databases

ProteinModelPortaliQ86VH2.
SMRiQ86VH2. Positions 2-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 341337Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili352 – 41362Sequence AnalysisAdd
BLAST
Coiled coili489 – 55769Sequence AnalysisAdd
BLAST
Coiled coili705 – 886182Sequence AnalysisAdd
BLAST
Coiled coili916 – 1070155Sequence AnalysisAdd
BLAST
Coiled coili1118 – 115437Sequence AnalysisAdd
BLAST
Coiled coili1190 – 121930Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOGENOMiHOG000068072.
HOVERGENiHBG054858.
InParanoidiQ86VH2.
KOiK10395.
OMAiRIFTFDF.
OrthoDBiEOG7K3TK3.
PhylomeDBiQ86VH2.
TreeFamiTF325946.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VH2-1) [UniParc]FASTAAdd to basket

Also known as: KIF27A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEIPVKVAV RIRPLLCKEA LHNHQVCVRV IPNSQQVIIG RDRVFTFDFV
60 70 80 90 100
FGKNSTQDEV YNTCIKPLVL SLIEGYNATV FAYGQTGSGK TYTIGGGHIA
110 120 130 140 150
SVVEGQKGII PRAIQEIFQS ISEHPSIDFN VKVSYIEVYK EDLRDLLELE
160 170 180 190 200
TSMKDLHIRE DEKGNTVIVG AKECHVESAG EVMSLLEMGN AARHTGTTQM
210 220 230 240 250
NEHSSRSHAI FTISICQVHK NMEAAEDGSW YSPRHIVSKF HFVDLAGSER
260 270 280 290 300
VTKTGNTGER FKESIQINSG LLALGNVISA LGDPRRKSSH IPYRDAKITR
310 320 330 340 350
LLKDSLGGSA KTVMITCVSP SSSNFDESLN SLKYANRARN IRNKPTVNFS
360 370 380 390 400
PESDRIDEME FEIKLLREAL QSQQAGVSQT TQINREGSPD TNRIHSLEEQ
410 420 430 440 450
VAQLQGECLG YQCCVEEAFT FLVDLKDTVR LNEKQQHKLQ EWFNMIQEVR
460 470 480 490 500
KAVLTSFRGI GGTASLEEGP QHVTVLQLKR ELKKCQCVLA ADEVVFNQKE
510 520 530 540 550
LEVKELKNQV QMMVQENKGH AVSLKEAQKV NRLQNEKIIE QQLLVDQLSE
560 570 580 590 600
ELTKLNLSVT SSAKENCGDG PDARIPERRP YTVPFDTHLG HYIYIPSRQD
610 620 630 640 650
SRKVHTSPPM YSLDRIFAGF RTRSQMLLGH IEEQDKVLHC QFSDNSDDEE
660 670 680 690 700
SEGQEKSGTR CRSRSWIQKP DSVCSLVELS DTQDETQKSD LENEDLKIDC
710 720 730 740 750
LQESQELNLQ KLKNSERILT EAKQKMRELT INIKMKEDLI KELIKTGNDA
760 770 780 790 800
KSVSKQYSLK VTKLEHDAEQ AKVELIETQK QLQELENKDL SDVAMKVKLQ
810 820 830 840 850
KEFRKKMDAA KLRVQVLQKK QQDSKKLASL SIQNEKRANE LEQSVDHMKY
860 870 880 890 900
QKIQLQRKLR EENEKRKQLD AVIKRDQQKI KEIQLKTGQE EGLKPKAEDL
910 920 930 940 950
DACNLKRRKG SFGSIDHLQK LDEQKKWLDE EVEKVLNQRQ ELEELEADLK
960 970 980 990 1000
KREAIVSKKE ALLQEKSHLE NKKLRSSQAL NTDSLKISTR LNLLEQELSE
1010 1020 1030 1040 1050
KNVQLQTSTA EEKTKISEQV EVLQKEKDQL QKRRHNVDEK LKNGRVLSPE
1060 1070 1080 1090 1100
EEHVLFQLEE GIEALEAAIE YRNESIQNRQ KSLRASFHNL SRGEANVLEK
1110 1120 1130 1140 1150
LACLSPVEIR TILFRYFNKV VNLREAERKQ QLYNEEMKMK VLERDNMVRE
1160 1170 1180 1190 1200
LESALDHLKL QCDRRLTLQQ KEHEQKMQLL LHHFKEQDGE GIMETFKTYE
1210 1220 1230 1240 1250
DKIQQLEKDL YFYKKTSRDH KKKLKELVGE AIRRQLAPSE YQEAGDGVLK
1260 1270 1280 1290 1300
PEGGGMLSEE LKWASRPESM KLSGREREMD SSASSLRTQP NPQKLWEDIP
1310 1320 1330 1340 1350
ELPPIHSSLA PPSGHMLGNE NKTETDDNQF TKSHSRLSSQ IQVVGNVGRL
1360 1370 1380 1390 1400
HGVTPVKLCR KELRQISALE LSLRRSSLGV GIGSMAADSI EVSRKPRDLK

T
Length:1,401
Mass (Da):160,283
Last modified:June 1, 2003 - v1
Checksum:i4563BA414C30DB21
GO
Isoform 2 (identifier: Q86VH2-2) [UniParc]FASTAAdd to basket

Also known as: KIF27B

The sequence of this isoform differs from the canonical sequence as follows:
     816-881: Missing.

Show »
Length:1,335
Mass (Da):152,314
Checksum:iD3D02A926D9E823F
GO
Isoform 3 (identifier: Q86VH2-3) [UniParc]FASTAAdd to basket

Also known as: KIF27C

The sequence of this isoform differs from the canonical sequence as follows:
     882-978: Missing.

Show »
Length:1,304
Mass (Da):148,978
Checksum:i7FEBD1BBC879016C
GO
Isoform 4 (identifier: Q86VH2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-609: Missing.
     882-896: EIQLKTGQEEGLKPK → VILSYIPAKYNMKC
     897-1401: Missing.

Show »
Length:286
Mass (Da):33,547
Checksum:iD68AE60C142EC48B
GO

Sequence cautioni

The sequence CAB63770.1 differs from that shown. Reason: Frameshift at position 728. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131I → V.
Corresponds to variant rs12001918 [ dbSNP | Ensembl ].
VAR_035361
Natural varianti300 – 3001R → Q.
Corresponds to variant rs35594736 [ dbSNP | Ensembl ].
VAR_035362
Natural varianti1036 – 10361N → D.1 Publication
Corresponds to variant rs55654273 [ dbSNP | Ensembl ].
VAR_061286

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 609609Missing in isoform 4. CuratedVSP_028602Add
BLAST
Alternative sequencei816 – 88166Missing in isoform 2. 1 PublicationVSP_028603Add
BLAST
Alternative sequencei882 – 97897Missing in isoform 3. 1 PublicationVSP_028604Add
BLAST
Alternative sequencei882 – 89615EIQLK…GLKPK → VILSYIPAKYNMKC in isoform 4. CuratedVSP_028605Add
BLAST
Alternative sequencei897 – 1401505Missing in isoform 4. CuratedVSP_028606Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237536 mRNA. Translation: AAP04413.1.
AY237537 mRNA. Translation: AAP04414.1.
AY237538 mRNA. Translation: AAP04415.1.
AL354733 Genomic DNA. Translation: CAI16012.1.
AL354733 Genomic DNA. Translation: CAI16013.1.
BC140788 mRNA. Translation: AAI40789.1.
AL133654 mRNA. Translation: CAB63770.1. Frameshift.
CCDSiCCDS65071.1. [Q86VH2-2]
CCDS65072.1. [Q86VH2-3]
CCDS6665.1. [Q86VH2-1]
PIRiT43446.
RefSeqiNP_001258856.1. NM_001271927.1. [Q86VH2-2]
NP_001258857.1. NM_001271928.1. [Q86VH2-3]
NP_060046.1. NM_017576.2. [Q86VH2-1]
XP_006717239.1. XM_006717176.1. [Q86VH2-1]
UniGeneiHs.697514.

Genome annotation databases

EnsembliENST00000297814; ENSP00000297814; ENSG00000165115. [Q86VH2-1]
ENST00000334204; ENSP00000333928; ENSG00000165115. [Q86VH2-3]
ENST00000376347; ENSP00000365525; ENSG00000165115. [Q86VH2-4]
ENST00000413982; ENSP00000401688; ENSG00000165115. [Q86VH2-2]
GeneIDi55582.
KEGGihsa:55582.
UCSCiuc004ana.4. human. [Q86VH2-1]
uc010mpw.4. human. [Q86VH2-2]
uc010mpx.4. human. [Q86VH2-3]

Polymorphism databases

DMDMi74750464.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237536 mRNA. Translation: AAP04413.1.
AY237537 mRNA. Translation: AAP04414.1.
AY237538 mRNA. Translation: AAP04415.1.
AL354733 Genomic DNA. Translation: CAI16012.1.
AL354733 Genomic DNA. Translation: CAI16013.1.
BC140788 mRNA. Translation: AAI40789.1.
AL133654 mRNA. Translation: CAB63770.1. Frameshift.
CCDSiCCDS65071.1. [Q86VH2-2]
CCDS65072.1. [Q86VH2-3]
CCDS6665.1. [Q86VH2-1]
PIRiT43446.
RefSeqiNP_001258856.1. NM_001271927.1. [Q86VH2-2]
NP_001258857.1. NM_001271928.1. [Q86VH2-3]
NP_060046.1. NM_017576.2. [Q86VH2-1]
XP_006717239.1. XM_006717176.1. [Q86VH2-1]
UniGeneiHs.697514.

3D structure databases

ProteinModelPortaliQ86VH2.
SMRiQ86VH2. Positions 2-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120730. 1 interaction.
IntActiQ86VH2. 1 interaction.
MINTiMINT-7944150.
STRINGi9606.ENSP00000297814.

PTM databases

PhosphoSiteiQ86VH2.

Polymorphism databases

DMDMi74750464.

Proteomic databases

MaxQBiQ86VH2.
PaxDbiQ86VH2.
PRIDEiQ86VH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297814; ENSP00000297814; ENSG00000165115. [Q86VH2-1]
ENST00000334204; ENSP00000333928; ENSG00000165115. [Q86VH2-3]
ENST00000376347; ENSP00000365525; ENSG00000165115. [Q86VH2-4]
ENST00000413982; ENSP00000401688; ENSG00000165115. [Q86VH2-2]
GeneIDi55582.
KEGGihsa:55582.
UCSCiuc004ana.4. human. [Q86VH2-1]
uc010mpw.4. human. [Q86VH2-2]
uc010mpx.4. human. [Q86VH2-3]

Organism-specific databases

CTDi55582.
GeneCardsiGC09M086451.
HGNCiHGNC:18632. KIF27.
HPAiHPA022246.
MIMi611253. gene.
neXtProtiNX_Q86VH2.
PharmGKBiPA134912901.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOGENOMiHOG000068072.
HOVERGENiHBG054858.
InParanoidiQ86VH2.
KOiK10395.
OMAiRIFTFDF.
OrthoDBiEOG7K3TK3.
PhylomeDBiQ86VH2.
TreeFamiTF325946.

Miscellaneous databases

GenomeRNAii55582.
NextBioi60090.
PROiQ86VH2.
SOURCEiSearch...

Gene expression databases

BgeeiQ86VH2.
CleanExiHS_KIF27.
ExpressionAtlasiQ86VH2. baseline and differential.
GenevestigatoriQ86VH2.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
    Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
    BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 4).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 569-1401 (ISOFORM 1), VARIANT ASP-1036.
    Tissue: Testis.

Entry informationi

Entry nameiKIF27_HUMAN
AccessioniPrimary (citable) accession number: Q86VH2
Secondary accession number(s): B2RTR8
, Q5T6W0, Q86VH0, Q86VH1, Q9UF54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2003
Last modified: March 4, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.