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Protein

Uncharacterized protein C11orf74

Gene

C11orf74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C11orf74
Alternative name(s):
Protein HEPIS
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25142. C11orf74.

Pathology & Biotechi

Organism-specific databases

DisGeNETi119710.
OpenTargetsiENSG00000166352.
PharmGKBiPA144596493.

Polymorphism and mutation databases

DMDMi74727571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888541 – 221Uncharacterized protein C11orf74Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86VG3.
MaxQBiQ86VG3.
PaxDbiQ86VG3.
PeptideAtlasiQ86VG3.
PRIDEiQ86VG3.

PTM databases

iPTMnetiQ86VG3.
PhosphoSitePlusiQ86VG3.

Expressioni

Gene expression databases

BgeeiENSG00000166352.
CleanExiHS_C11orf74.
ExpressionAtlasiQ86VG3. baseline and differential.
GenevisibleiQ86VG3. HS.

Organism-specific databases

HPAiHPA044880.

Interactioni

Protein-protein interaction databases

BioGridi125655. 10 interactors.
IntActiQ86VG3. 3 interactors.
STRINGi9606.ENSP00000334848.

Structurei

3D structure databases

ProteinModelPortaliQ86VG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVZ8. Eukaryota.
ENOG4112BAY. LUCA.
GeneTreeiENSGT00390000013149.
HOGENOMiHOG000111739.
HOVERGENiHBG103240.
InParanoidiQ86VG3.
OMAiNEPNDHH.
OrthoDBiEOG091G0JGG.
PhylomeDBiQ86VG3.
TreeFamiTF335968.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VG3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAHMSGLEI MDEDQLIKDV LDKFLNCHEQ TYDEEFLNTF THLSQEDHVS
60 70 80 90 100
KRGVFGTDSS ENIFTSAKVT HKNEADDYHL RNKTIFLRTS SQCLEEQVDN
110 120 130 140 150
FLDLEDLDMD EEIKPQMSED LLLLPGEVEQ DVSTSIPSCI PFVAQPPTCE
160 170 180 190 200
VKPKPSVKRM DKQTEEILGD EVQLFSLDEE FDYDNVMLTS KFSPAEIENI
210 220
KELCKQQKRK DTSPDLEKSC D
Length:221
Mass (Da):25,407
Last modified:June 1, 2003 - v1
Checksum:i7C75C1C2061207D4
GO
Isoform 2 (identifier: Q86VG3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-119: Missing.

Show »
Length:147
Mass (Da):16,847
Checksum:iE8A16798E7F345F5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02579346 – 119Missing in isoform 2. 2 PublicationsAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ121386 mRNA. Translation: AAZ29248.1.
CH471064 Genomic DNA. Translation: EAW68112.1.
CH471064 Genomic DNA. Translation: EAW68113.1.
CH471064 Genomic DNA. Translation: EAW68114.1.
CH471064 Genomic DNA. Translation: EAW68115.1.
BC009561 mRNA. Translation: AAH09561.1.
BC051031 mRNA. Translation: AAH51031.1.
CCDSiCCDS60762.1. [Q86VG3-2]
CCDS7904.1. [Q86VG3-1]
RefSeqiNP_001263651.1. NM_001276722.1. [Q86VG3-1]
NP_001263652.1. NM_001276723.1. [Q86VG3-1]
NP_001263653.1. NM_001276724.1. [Q86VG3-1]
NP_001263654.1. NM_001276725.1. [Q86VG3-2]
NP_001263655.1. NM_001276726.1. [Q86VG3-2]
NP_001263656.1. NM_001276727.1. [Q86VG3-2]
NP_620142.2. NM_138787.3. [Q86VG3-1]
XP_006718201.1. XM_006718138.3. [Q86VG3-1]
XP_011518187.1. XM_011519885.2. [Q86VG3-1]
UniGeneiHs.159376.

Genome annotation databases

EnsembliENST00000334307; ENSP00000334848; ENSG00000166352. [Q86VG3-1]
ENST00000347206; ENSP00000299442; ENSG00000166352. [Q86VG3-2]
ENST00000446510; ENSP00000403937; ENSG00000166352. [Q86VG3-1]
ENST00000532470; ENSP00000431374; ENSG00000166352. [Q86VG3-1]
ENST00000534635; ENSP00000433152; ENSG00000166352. [Q86VG3-2]
ENST00000617650; ENSP00000483671; ENSG00000166352. [Q86VG3-1]
GeneIDi119710.
KEGGihsa:119710.
UCSCiuc001mwy.3. human. [Q86VG3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ121386 mRNA. Translation: AAZ29248.1.
CH471064 Genomic DNA. Translation: EAW68112.1.
CH471064 Genomic DNA. Translation: EAW68113.1.
CH471064 Genomic DNA. Translation: EAW68114.1.
CH471064 Genomic DNA. Translation: EAW68115.1.
BC009561 mRNA. Translation: AAH09561.1.
BC051031 mRNA. Translation: AAH51031.1.
CCDSiCCDS60762.1. [Q86VG3-2]
CCDS7904.1. [Q86VG3-1]
RefSeqiNP_001263651.1. NM_001276722.1. [Q86VG3-1]
NP_001263652.1. NM_001276723.1. [Q86VG3-1]
NP_001263653.1. NM_001276724.1. [Q86VG3-1]
NP_001263654.1. NM_001276725.1. [Q86VG3-2]
NP_001263655.1. NM_001276726.1. [Q86VG3-2]
NP_001263656.1. NM_001276727.1. [Q86VG3-2]
NP_620142.2. NM_138787.3. [Q86VG3-1]
XP_006718201.1. XM_006718138.3. [Q86VG3-1]
XP_011518187.1. XM_011519885.2. [Q86VG3-1]
UniGeneiHs.159376.

3D structure databases

ProteinModelPortaliQ86VG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125655. 10 interactors.
IntActiQ86VG3. 3 interactors.
STRINGi9606.ENSP00000334848.

PTM databases

iPTMnetiQ86VG3.
PhosphoSitePlusiQ86VG3.

Polymorphism and mutation databases

DMDMi74727571.

Proteomic databases

EPDiQ86VG3.
MaxQBiQ86VG3.
PaxDbiQ86VG3.
PeptideAtlasiQ86VG3.
PRIDEiQ86VG3.

Protocols and materials databases

DNASUi119710.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334307; ENSP00000334848; ENSG00000166352. [Q86VG3-1]
ENST00000347206; ENSP00000299442; ENSG00000166352. [Q86VG3-2]
ENST00000446510; ENSP00000403937; ENSG00000166352. [Q86VG3-1]
ENST00000532470; ENSP00000431374; ENSG00000166352. [Q86VG3-1]
ENST00000534635; ENSP00000433152; ENSG00000166352. [Q86VG3-2]
ENST00000617650; ENSP00000483671; ENSG00000166352. [Q86VG3-1]
GeneIDi119710.
KEGGihsa:119710.
UCSCiuc001mwy.3. human. [Q86VG3-1]

Organism-specific databases

CTDi119710.
DisGeNETi119710.
GeneCardsiC11orf74.
HGNCiHGNC:25142. C11orf74.
HPAiHPA044880.
neXtProtiNX_Q86VG3.
OpenTargetsiENSG00000166352.
PharmGKBiPA144596493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVZ8. Eukaryota.
ENOG4112BAY. LUCA.
GeneTreeiENSGT00390000013149.
HOGENOMiHOG000111739.
HOVERGENiHBG103240.
InParanoidiQ86VG3.
OMAiNEPNDHH.
OrthoDBiEOG091G0JGG.
PhylomeDBiQ86VG3.
TreeFamiTF335968.

Miscellaneous databases

GenomeRNAii119710.
PROiQ86VG3.

Gene expression databases

BgeeiENSG00000166352.
CleanExiHS_C11orf74.
ExpressionAtlasiQ86VG3. baseline and differential.
GenevisibleiQ86VG3. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCK074_HUMAN
AccessioniPrimary (citable) accession number: Q86VG3
Secondary accession number(s): D3DR18, Q96DD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.