Q86VF7 (NRAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nebulin-related-anchoring protein
Short name=N-RAP

Gene names

Name:

NRAP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1730 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix By similarity. UniProtKB Q80XB4
Subunit structure	Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL By similarity.
Subcellular location	Note: Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. Ref.1
Tissue specificity	Expressed in cardiac and skeletal muscle. Ref.1
Sequence similarities	Contains 1 LIM zinc-binding domain. Contains 44 nebulin repeats.
Sequence caution	The sequence AAH58825.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH70130.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAQ09536.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC04884.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	LIM domain Repeat
Ligand	Actin-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	fascia adherens Inferred from sequence or structural similarity. Source: UniProtKB muscle tendon junction Inferred from sequence or structural similarity. Source: UniProtKB myofibril Inferred from electronic annotation. Source: Compara
Molecular_function	actin binding Inferred from sequence or structural similarity. Source: UniProtKB muscle alpha-actinin binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 Ref.3 (identifier: Q86VF7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.4 (identifier: Q86VF7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     580-580: N → NVHLLLSLK

Note: Gene prediction based on EST data.

Isoform 3 Ref.4 (identifier: Q86VF7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.
     580-580: N → NVHLLLSLK

Note: Gene prediction based on EST data.

Isoform 4 Ref.1 Ref.2 (identifier: Q86VF7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1730	1730	Nebulin-related-anchoring protein		PRO_0000250425
Regions
	Domain	4 – 64	61	LIM zinc-binding
	Repeat	63 – 97	35	Nebulin 1
	Repeat	156 – 166	11	Nebulin 2
	Repeat	175 – 202	28	Nebulin 3
	Repeat	203 – 237	35	Nebulin 4
	Repeat	246 – 273	28	Nebulin 5
	Repeat	298 – 307	10	Nebulin 6
	Repeat	316 – 343	28	Nebulin 7
	Repeat	348 – 382	35	Nebulin 8
	Repeat	389 – 417	29	Nebulin 9
	Repeat	419 – 453	35	Nebulin 10
	Repeat	487 – 521	35	Nebulin 11
	Repeat	522 – 556	35	Nebulin 12
	Repeat	558 – 592	35	Nebulin 13
	Repeat	602 – 626	25	Nebulin 14
	Repeat	627 – 661	35	Nebulin 15
	Repeat	662 – 692	31	Nebulin 16
	Repeat	702 – 724	23	Nebulin 17
	Repeat	726 – 760	35	Nebulin 18
	Repeat	761 – 795	35	Nebulin 19
	Repeat	797 – 831	35	Nebulin 20
	Repeat	844 – 869	26	Nebulin 21
	Repeat	870 – 896	27	Nebulin 22
	Repeat	901 – 935	35	Nebulin 23
	Repeat	945 – 963	19	Nebulin 24
	Repeat	969 – 1003	35	Nebulin 25
	Repeat	1004 – 1038	35	Nebulin 26
	Repeat	1040 – 1074	35	Nebulin 27
	Repeat	1078 – 1112	35	Nebulin 28
	Repeat	1113 – 1139	27	Nebulin 29
	Repeat	1144 – 1178	35	Nebulin 30
	Repeat	1183 – 1206	24	Nebulin 31
	Repeat	1212 – 1246	35	Nebulin 32
	Repeat	1247 – 1281	35	Nebulin 33
	Repeat	1283 – 1317	35	Nebulin 34
	Repeat	1321 – 1355	35	Nebulin 35
	Repeat	1356 – 1390	35	Nebulin 36
	Repeat	1391 – 1421	31	Nebulin 37
	Repeat	1429 – 1449	21	Nebulin 38
	Repeat	1455 – 1481	27	Nebulin 39
	Repeat	1490 – 1524	35	Nebulin 40
	Repeat	1526 – 1560	35	Nebulin 41
	Repeat	1564 – 1598	35	Nebulin 42
	Repeat	1599 – 1626	28	Nebulin 43
	Repeat	1640 – 1664	25	Nebulin 44
Natural variations
	Alternative sequence	371 – 405	35	Missing in isoform 3 and isoform 4. Ref.1 Ref.2 Ref.4		VSP_052165
	Alternative sequence	580	1	N → NVHLLLSLK in isoform 2 and isoform 3. Ref.4		VSP_052166
	Natural variant	132	1	A → S. Corresponds to variant rs34700024 [ dbSNP | Ensembl ].		VAR_034073
	Natural variant	186	1	Q → E. Corresponds to variant rs35049661 [ dbSNP | Ensembl ].		VAR_034074
	Natural variant	208	1	V → A. Ref.2 Ref.3 Ref.3 Ref.5 Ref.6 Corresponds to variant rs2154028 [ dbSNP | Ensembl ].		VAR_027556
	Natural variant	249	1	Y → C. Ref.3 Ref.3 Corresponds to variant rs2185913 [ dbSNP | Ensembl ].		VAR_027557
	Natural variant	282	1	A → T. Corresponds to variant rs2275799 [ dbSNP | Ensembl ].		VAR_034075
	Natural variant	344	1	A → T. Ref.2 Ref.3 Ref.3 Ref.5 Corresponds to variant rs3121478 [ dbSNP | Ensembl ].		VAR_027558
	Natural variant	360	1	Q → R. Ref.2 Ref.3 Ref.3 Ref.5 Corresponds to variant rs3127106 [ dbSNP | Ensembl ].		VAR_027559
	Natural variant	484	1	D → N. Corresponds to variant rs11196400 [ dbSNP | Ensembl ].		VAR_050160
	Natural variant	490	1	S → L. Ref.3 Ref.4 Corresponds to variant rs3189030 [ dbSNP | Ensembl ].		VAR_034076
	Natural variant	519	1	N → I. Corresponds to variant rs2270182 [ dbSNP | Ensembl ].		VAR_034077
	Natural variant	647	1	A → S. Corresponds to variant rs2286734 [ dbSNP | Ensembl ].		VAR_050161
	Natural variant	674	1	A → V. Ref.2 Corresponds to variant rs2286735 [ dbSNP | Ensembl ].		VAR_034078
	Natural variant	884	1	R → C. Ref.3 Corresponds to variant rs868738 [ dbSNP | Ensembl ].		VAR_034079
	Natural variant	1022	1	M → V. Corresponds to variant rs34523503 [ dbSNP | Ensembl ].		VAR_061357
	Natural variant	1112	1	A → V. Ref.3 Corresponds to variant rs1539587 [ dbSNP | Ensembl ].		VAR_034080
	Natural variant	1183	1	I → V. Ref.1 Ref.3 Corresponds to variant rs10749138 [ dbSNP | Ensembl ].		VAR_050162
	Natural variant	1531	1	L → P. Ref.3 Ref.3 Corresponds to variant rs11196389 [ dbSNP | Ensembl ].		VAR_027560
	Natural variant	1566	1	R → C. Ref.3 Corresponds to variant rs1885434 [ dbSNP | Ensembl ].		VAR_050163
	Natural variant	1569	1	D → N. Corresponds to variant rs11575798 [ dbSNP | Ensembl ].		VAR_050164
	Natural variant	1643	1	A → S. Corresponds to variant rs11575797 [ dbSNP | Ensembl ].		VAR_050165
Experimental info
	Sequence conflict	224	1	S → N in CAD38623. Ref.3
	Sequence conflict	261	1	D → G in CAD89910. Ref.3
	Sequence conflict	338	1	F → S in CAE45846. Ref.3
	Sequence conflict	395	1	N → D in CAD38623. Ref.3
	Sequence conflict	488	1	Y → H in CAE45811. Ref.3
	Sequence conflict	545	1	V → A in BAB71328. Ref.5
	Sequence conflict	658	1	E → G in CAD89910. Ref.3
	Sequence conflict	862	1	K → E in CAD89910. Ref.3
	Sequence conflict	862	1	K → E in CAE45846. Ref.3
	Sequence conflict	1210	1	S → P in CAE45846. Ref.3
	Sequence conflict	1236	1	L → F in CAD89910. Ref.3
	Sequence conflict	1260	1	A → V in CAE45846. Ref.3
	Sequence conflict	1348	1	R → K in CAE45846. Ref.3
	Sequence conflict	1357	1	F → L in CAD89899. Ref.3
	Sequence conflict	1414	1	S → L in CAE45846. Ref.3
	Sequence conflict	1563	1	I → V in CAD89910. Ref.3
	Sequence conflict	1607	1	P → H in CAD89910. Ref.3
	Sequence conflict	1672	1	S → P in CAD38623. Ref.3
	Sequence conflict	1696	1	Y → YQ in CAD89910. Ref.3
	Sequence conflict	1696	1	Y → YQ in CAD89998. Ref.3
	Sequence conflict	1696	1	Y → YQ Ref.4
	Sequence conflict	1697	1	R → Q in CAD89899. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: 2F6AD0C7C07EC797	FASTA	1,730	197,074
	10 20 30 40 50 60 MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK KPYCHAHNPK 70 80 90 100 110 120 NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH WDMKSKDKEG APNRQPLANE 130 140 150 160 170 180 RAYWTGYGEG NAWCPGALPD PEIVRMVEAR KSLGEEYTED YEQPRGKGSF PAMITPAYQR 190 200 210 220 230 240 AKKANQLASQ VEYKRGHDER ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS 250 260 270 280 290 300 FPAMITPAYQ IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE 310 320 330 340 350 360 EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL PAQDNLVLKQ 370 380 390 400 410 420 AQSVNKLVSE VEYKKDLESS RGHSINYCET PQFRNVSKIS KFTSDNKYKE NYQNHMRGRY 430 440 450 460 470 480 EGVGMDRRTL HAMKVGSLAS NVAYKADYKH DIVDYNYPAT LTPSYQTAMK LVPLKDANYR 490 500 510 520 530 540 QSIDKLKYSS VTDTPQIVQA KINAQQLSHV NYRADYEKNK LNYTLPQDVP QLVKAKTNAK 550 560 570 580 590 600 LFSEVKYKEG WEKTKGKGFE MKLDAMSLLA AKASGELASN IKYKEEYEKT KGKAMGTADS 610 620 630 640 650 660 RLLHSLQIAK MSSEVEYKKG FEESKTRFHL PMDMVNIRHA KKAQTLASDL DYRKKLHEYT 670 680 690 700 710 720 VLPEDMKTQW AKKAYGLQSE LQYKADLAWM KGVGWLTEGS LNLEQAKKAG QLVSEKNYRQ 730 740 750 760 770 780 RVDELKFTSV TDSSQMEHAK KSQELQSGVA YKAGNEQSVH QYTISKDEPL FLQARANAAN 790 800 810 820 830 840 LSEKLYKSSW ENQKAKGFEL RLDSLTFLAA KAKRDLASEV KYKEDYERSR GKLIGAKDVQ 850 860 870 880 890 900 GDSQMSHSLQ MSKLQSELEY KKGFEDTKSQ CHVSLDMVHL VHARKAQHLA TDVGYKTAEH 910 920 930 940 950 960 HFTALPTDMK VEWAKKAYGL QSDNQYRADV KWMKGMGWVA TGSLNVEQAK KAGELISEKK 970 980 990 1000 1010 1020 YRQHPDALKF TSIKDTPEMV QARISYTQAV DRLYREQGEN IKHHYTPTAD LPEVLLAKLN 1030 1040 1050 1060 1070 1080 AMNISETRYK ESWSKLRDGG YKLRLDALPF QAAKASGEII SDYKYKEAFE KMKGQMLGSR 1090 1100 1110 1120 1130 1140 SLEDDISLAH SVYATSLQSD VNYKKGFEHS KAQFHLPLDM AALVHAKKAQ TLASNQDYKH 1150 1160 1170 1180 1190 1200 PLPQYTSLAE DLRLSCAKKA HKLQSENLYR SDLNFMRGVA CVIPGTLEIE GRKKASELIS 1210 1220 1230 1240 1250 1260 ESKYRQHPHS FKYTAVTDTP NLLHAKFSNQ ITNERLYKAA GEDARHEYTM TLGLPEFIRA 1270 1280 1290 1300 1310 1320 KTNAANLSDA RYKESWRNLR AQGYKLTIEA LPFQAARASG DIASDFLYRH DFVKERGKLI 1330 1340 1350 1360 1370 1380 GPQSVRDDPR IQHCRRMGQL QSELQYRRGA TSSQAQFHLP MDMVHLVHAK NAQALASDHD 1390 1400 1410 1420 1430 1440 YRTQYHKFTA LPEDLKMAWA KKAHALQSEL RYKSDLIGMK GIGWLALRSP QMESAKKAGE 1450 1460 1470 1480 1490 1500 LISETKYRKK PDSIKFTTVV DSPDLVHAKN SYMHCNERMY RSGDAESLHR YTLIPDHPDF 1510 1520 1530 1540 1550 1560 TRARLNALHL SDKVYRNSWE QTRAGSYDFR LDAIPFQTAR ASREIASDFR YKEAFLRDRG 1570 1580 1590 1600 1610 1620 LQIGYRSVDD DPRMKHFLNV GRLQSDNEYK KDFAKSRSQF HSSTDQPGLL QAKRSQQLAS 1630 1640 1650 1660 1670 1680 DVHYRQPLPQ PTCDPEQLGL RHAQKAHQLQ SDVKYKSDLN LTRGVGWTPP GSYKVEMARR 1690 1700 1710 1720 1730 AAELANARGL GLQGAYRGAE AVEAGDHQSG EVNPDATEIL HVKKKKALLL
	Isoform 2 [UniParc]. Checksum: D6A39759359FB9BF	FASTA	1,738	197,978
	10 20 30 40 50 60 MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK KPYCHAHNPK 70 80 90 100 110 120 NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH WDMKSKDKEG APNRQPLANE 130 140 150 160 170 180 RAYWTGYGEG NAWCPGALPD PEIVRMVEAR KSLGEEYTED YEQPRGKGSF PAMITPAYQR 190 200 210 220 230 240 AKKANQLASQ VEYKRGHDER ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS 250 260 270 280 290 300 FPAMITPAYQ IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE 310 320 330 340 350 360 EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL PAQDNLVLKQ 370 380 390 400 410 420 AQSVNKLVSE VEYKKDLESS RGHSINYCET PQFRNVSKIS KFTSDNKYKE NYQNHMRGRY 430 440 450 460 470 480 EGVGMDRRTL HAMKVGSLAS NVAYKADYKH DIVDYNYPAT LTPSYQTAMK LVPLKDANYR 490 500 510 520 530 540 QSIDKLKYSS VTDTPQIVQA KINAQQLSHV NYRADYEKNK LNYTLPQDVP QLVKAKTNAK 550 560 570 580 590 600 LFSEVKYKEG WEKTKGKGFE MKLDAMSLLA AKASGELASN VHLLLSLKIK YKEEYEKTKG 610 620 630 640 650 660 KAMGTADSRL LHSLQIAKMS SEVEYKKGFE ESKTRFHLPM DMVNIRHAKK AQTLASDLDY 670 680 690 700 710 720 RKKLHEYTVL PEDMKTQWAK KAYGLQSELQ YKADLAWMKG VGWLTEGSLN LEQAKKAGQL 730 740 750 760 770 780 VSEKNYRQRV DELKFTSVTD SSQMEHAKKS QELQSGVAYK AGNEQSVHQY TISKDEPLFL 790 800 810 820 830 840 QARANAANLS EKLYKSSWEN QKAKGFELRL DSLTFLAAKA KRDLASEVKY KEDYERSRGK 850 860 870 880 890 900 LIGAKDVQGD SQMSHSLQMS KLQSELEYKK GFEDTKSQCH VSLDMVHLVH ARKAQHLATD 910 920 930 940 950 960 VGYKTAEHHF TALPTDMKVE WAKKAYGLQS DNQYRADVKW MKGMGWVATG SLNVEQAKKA 970 980 990 1000 1010 1020 GELISEKKYR QHPDALKFTS IKDTPEMVQA RISYTQAVDR LYREQGENIK HHYTPTADLP 1030 1040 1050 1060 1070 1080 EVLLAKLNAM NISETRYKES WSKLRDGGYK LRLDALPFQA AKASGEIISD YKYKEAFEKM 1090 1100 1110 1120 1130 1140 KGQMLGSRSL EDDISLAHSV YATSLQSDVN YKKGFEHSKA QFHLPLDMAA LVHAKKAQTL 1150 1160 1170 1180 1190 1200 ASNQDYKHPL PQYTSLAEDL RLSCAKKAHK LQSENLYRSD LNFMRGVACV IPGTLEIEGR 1210 1220 1230 1240 1250 1260 KKASELISES KYRQHPHSFK YTAVTDTPNL LHAKFSNQIT NERLYKAAGE DARHEYTMTL 1270 1280 1290 1300 1310 1320 GLPEFIRAKT NAANLSDARY KESWRNLRAQ GYKLTIEALP FQAARASGDI ASDFLYRHDF 1330 1340 1350 1360 1370 1380 VKERGKLIGP QSVRDDPRIQ HCRRMGQLQS ELQYRRGATS SQAQFHLPMD MVHLVHAKNA 1390 1400 1410 1420 1430 1440 QALASDHDYR TQYHKFTALP EDLKMAWAKK AHALQSELRY KSDLIGMKGI GWLALRSPQM 1450 1460 1470 1480 1490 1500 ESAKKAGELI SETKYRKKPD SIKFTTVVDS PDLVHAKNSY MHCNERMYRS GDAESLHRYT 1510 1520 1530 1540 1550 1560 LIPDHPDFTR ARLNALHLSD KVYRNSWEQT RAGSYDFRLD AIPFQTARAS REIASDFRYK 1570 1580 1590 1600 1610 1620 EAFLRDRGLQ IGYRSVDDDP RMKHFLNVGR LQSDNEYKKD FAKSRSQFHS STDQPGLLQA 1630 1640 1650 1660 1670 1680 KRSQQLASDV HYRQPLPQPT CDPEQLGLRH AQKAHQLQSD VKYKSDLNLT RGVGWTPPGS 1690 1700 1710 1720 1730 YKVEMARRAA ELANARGLGL QGAYRGAEAV EAGDHQSGEV NPDATEILHV KKKKALLL
	Isoform 3 [UniParc]. Checksum: E7FA287C6611A0CD	FASTA	1,703	193,902
	10 20 30 40 50 60 MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK KPYCHAHNPK 70 80 90 100 110 120 NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH WDMKSKDKEG APNRQPLANE 130 140 150 160 170 180 RAYWTGYGEG NAWCPGALPD PEIVRMVEAR KSLGEEYTED YEQPRGKGSF PAMITPAYQR 190 200 210 220 230 240 AKKANQLASQ VEYKRGHDER ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS 250 260 270 280 290 300 FPAMITPAYQ IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE 310 320 330 340 350 360 EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL PAQDNLVLKQ 370 380 390 400 410 420 AQSVNKLVSE NKYKENYQNH MRGRYEGVGM DRRTLHAMKV GSLASNVAYK ADYKHDIVDY 430 440 450 460 470 480 NYPATLTPSY QTAMKLVPLK DANYRQSIDK LKYSSVTDTP QIVQAKINAQ QLSHVNYRAD 490 500 510 520 530 540 YEKNKLNYTL PQDVPQLVKA KTNAKLFSEV KYKEGWEKTK GKGFEMKLDA MSLLAAKASG 550 560 570 580 590 600 ELASNVHLLL SLKIKYKEEY EKTKGKAMGT ADSRLLHSLQ IAKMSSEVEY KKGFEESKTR 610 620 630 640 650 660 FHLPMDMVNI RHAKKAQTLA SDLDYRKKLH EYTVLPEDMK TQWAKKAYGL QSELQYKADL 670 680 690 700 710 720 AWMKGVGWLT EGSLNLEQAK KAGQLVSEKN YRQRVDELKF TSVTDSSQME HAKKSQELQS 730 740 750 760 770 780 GVAYKAGNEQ SVHQYTISKD EPLFLQARAN AANLSEKLYK SSWENQKAKG FELRLDSLTF 790 800 810 820 830 840 LAAKAKRDLA SEVKYKEDYE RSRGKLIGAK DVQGDSQMSH SLQMSKLQSE LEYKKGFEDT 850 860 870 880 890 900 KSQCHVSLDM VHLVHARKAQ HLATDVGYKT AEHHFTALPT DMKVEWAKKA YGLQSDNQYR 910 920 930 940 950 960 ADVKWMKGMG WVATGSLNVE QAKKAGELIS EKKYRQHPDA LKFTSIKDTP EMVQARISYT 970 980 990 1000 1010 1020 QAVDRLYREQ GENIKHHYTP TADLPEVLLA KLNAMNISET RYKESWSKLR DGGYKLRLDA 1030 1040 1050 1060 1070 1080 LPFQAAKASG EIISDYKYKE AFEKMKGQML GSRSLEDDIS LAHSVYATSL QSDVNYKKGF 1090 1100 1110 1120 1130 1140 EHSKAQFHLP LDMAALVHAK KAQTLASNQD YKHPLPQYTS LAEDLRLSCA KKAHKLQSEN 1150 1160 1170 1180 1190 1200 LYRSDLNFMR GVACVIPGTL EIEGRKKASE LISESKYRQH PHSFKYTAVT DTPNLLHAKF 1210 1220 1230 1240 1250 1260 SNQITNERLY KAAGEDARHE YTMTLGLPEF IRAKTNAANL SDARYKESWR NLRAQGYKLT 1270 1280 1290 1300 1310 1320 IEALPFQAAR ASGDIASDFL YRHDFVKERG KLIGPQSVRD DPRIQHCRRM GQLQSELQYR 1330 1340 1350 1360 1370 1380 RGATSSQAQF HLPMDMVHLV HAKNAQALAS DHDYRTQYHK FTALPEDLKM AWAKKAHALQ 1390 1400 1410 1420 1430 1440 SELRYKSDLI GMKGIGWLAL RSPQMESAKK AGELISETKY RKKPDSIKFT TVVDSPDLVH 1450 1460 1470 1480 1490 1500 AKNSYMHCNE RMYRSGDAES LHRYTLIPDH PDFTRARLNA LHLSDKVYRN SWEQTRAGSY 1510 1520 1530 1540 1550 1560 DFRLDAIPFQ TARASREIAS DFRYKEAFLR DRGLQIGYRS VDDDPRMKHF LNVGRLQSDN 1570 1580 1590 1600 1610 1620 EYKKDFAKSR SQFHSSTDQP GLLQAKRSQQ LASDVHYRQP LPQPTCDPEQ LGLRHAQKAH 1630 1640 1650 1660 1670 1680 QLQSDVKYKS DLNLTRGVGW TPPGSYKVEM ARRAAELANA RGLGLQGAYR GAEAVEAGDH 1690 1700 QSGEVNPDAT EILHVKKKKA LLL
	Isoform 4 [UniParc]. Checksum: FA5D00F9978B811A	FASTA	1,695	192,997
	10 20 30 40 50 60 MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK KPYCHAHNPK 70 80 90 100 110 120 NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH WDMKSKDKEG APNRQPLANE 130 140 150 160 170 180 RAYWTGYGEG NAWCPGALPD PEIVRMVEAR KSLGEEYTED YEQPRGKGSF PAMITPAYQR 190 200 210 220 230 240 AKKANQLASQ VEYKRGHDER ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS 250 260 270 280 290 300 FPAMITPAYQ IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE 310 320 330 340 350 360 EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL PAQDNLVLKQ 370 380 390 400 410 420 AQSVNKLVSE NKYKENYQNH MRGRYEGVGM DRRTLHAMKV GSLASNVAYK ADYKHDIVDY 430 440 450 460 470 480 NYPATLTPSY QTAMKLVPLK DANYRQSIDK LKYSSVTDTP QIVQAKINAQ QLSHVNYRAD 490 500 510 520 530 540 YEKNKLNYTL PQDVPQLVKA KTNAKLFSEV KYKEGWEKTK GKGFEMKLDA MSLLAAKASG 550 560 570 580 590 600 ELASNIKYKE EYEKTKGKAM GTADSRLLHS LQIAKMSSEV EYKKGFEESK TRFHLPMDMV 610 620 630 640 650 660 NIRHAKKAQT LASDLDYRKK LHEYTVLPED MKTQWAKKAY GLQSELQYKA DLAWMKGVGW 670 680 690 700 710 720 LTEGSLNLEQ AKKAGQLVSE KNYRQRVDEL KFTSVTDSSQ MEHAKKSQEL QSGVAYKAGN 730 740 750 760 770 780 EQSVHQYTIS KDEPLFLQAR ANAANLSEKL YKSSWENQKA KGFELRLDSL TFLAAKAKRD 790 800 810 820 830 840 LASEVKYKED YERSRGKLIG AKDVQGDSQM SHSLQMSKLQ SELEYKKGFE DTKSQCHVSL 850 860 870 880 890 900 DMVHLVHARK AQHLATDVGY KTAEHHFTAL PTDMKVEWAK KAYGLQSDNQ YRADVKWMKG 910 920 930 940 950 960 MGWVATGSLN VEQAKKAGEL ISEKKYRQHP DALKFTSIKD TPEMVQARIS YTQAVDRLYR 970 980 990 1000 1010 1020 EQGENIKHHY TPTADLPEVL LAKLNAMNIS ETRYKESWSK LRDGGYKLRL DALPFQAAKA 1030 1040 1050 1060 1070 1080 SGEIISDYKY KEAFEKMKGQ MLGSRSLEDD ISLAHSVYAT SLQSDVNYKK GFEHSKAQFH 1090 1100 1110 1120 1130 1140 LPLDMAALVH AKKAQTLASN QDYKHPLPQY TSLAEDLRLS CAKKAHKLQS ENLYRSDLNF 1150 1160 1170 1180 1190 1200 MRGVACVIPG TLEIEGRKKA SELISESKYR QHPHSFKYTA VTDTPNLLHA KFSNQITNER 1210 1220 1230 1240 1250 1260 LYKAAGEDAR HEYTMTLGLP EFIRAKTNAA NLSDARYKES WRNLRAQGYK LTIEALPFQA 1270 1280 1290 1300 1310 1320 ARASGDIASD FLYRHDFVKE RGKLIGPQSV RDDPRIQHCR RMGQLQSELQ YRRGATSSQA 1330 1340 1350 1360 1370 1380 QFHLPMDMVH LVHAKNAQAL ASDHDYRTQY HKFTALPEDL KMAWAKKAHA LQSELRYKSD 1390 1400 1410 1420 1430 1440 LIGMKGIGWL ALRSPQMESA KKAGELISET KYRKKPDSIK FTTVVDSPDL VHAKNSYMHC 1450 1460 1470 1480 1490 1500 NERMYRSGDA ESLHRYTLIP DHPDFTRARL NALHLSDKVY RNSWEQTRAG SYDFRLDAIP 1510 1520 1530 1540 1550 1560 FQTARASREI ASDFRYKEAF LRDRGLQIGY RSVDDDPRMK HFLNVGRLQS DNEYKKDFAK 1570 1580 1590 1600 1610 1620 SRSQFHSSTD QPGLLQAKRS QQLASDVHYR QPLPQPTCDP EQLGLRHAQK AHQLQSDVKY 1630 1640 1650 1660 1670 1680 KSDLNLTRGV GWTPPGSYKV EMARRAAELA NARGLGLQGA YRGAEAVEAG DHQSGEVNPD 1690 ATEILHVKKK KALLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization, alternative splicing, and expression of human and mouse N-RAP, a nebulin-related LIM protein of striated muscle." Mohiddin S.A., Lu S., Cardoso J.-P., Carroll S., Jha S., Horowits R., Fananapazir L. Cell Motil. Cytoskeleton 55:200-212(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT VAL-1183.
[2]	"Human Nrap, a novel gene which interact with actin." Yuan H.F., Wang X., Wang D.M., Li H.M., Feng K., Bai C.X., Zhang R., Chen L., Li Y.H., Gao Y.H., Zhen M., Yue W., Xie C., Xie X.Y., Niu L.L., Gao W.J., Zhang J., Cao H., Pei X.T. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS ALA-208; THR-344; ARG-360 AND VAL-674. Tissue: Skeletal muscle.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-208; CYS-249; THR-344; ARG-360; LEU-490; CYS-884; VAL-1112; VAL-1183; PRO-1531 AND CYS-1566. Tissue: Skeletal muscle.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-490.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-580 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1311-1730 (ISOFORM 1), VARIANTS ALA-208; THR-344 AND ARG-360. Tissue: Skeletal muscle.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-270 (ISOFORM 1), VARIANT ALA-208. Tissue: Skeletal muscle.
[7]	"Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes." Luo G., Leroy E., Kozak C.A., Polymeropoulos M.H., Horowits R. Genomics 45:229-232(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1004-1080 (ISOFORM 1).
[8]	"Cloning and characterization of a novel human gene encoding a protein of 394 amino acids with significant motif of nebulin signature IV and nebulin repeat." Zhang D.L., Cai J.J., Ma D.L. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1314-1730 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY177620 mRNA. Translation: AAO47073.1. AY177621 mRNA. Translation: AAO47074.1. AY081943 mRNA. Translation: AAL99185.2. AL831980 mRNA. Translation: CAD89899.1. AL832025 mRNA. Translation: CAD89910.1. AL832330 mRNA. Translation: CAD38623.1. AL832457 mRNA. Translation: CAD89998.1. BX640682 mRNA. Translation: CAE45811.1. BX640730 mRNA. Translation: CAE45846.1. BX641052 mRNA. Translation: CAE46027.1. AL390197 Genomic DNA. Translation: CAH71110.1. AL390197 Genomic DNA. Translation: CAH71111.1. AK056969 mRNA. Translation: BAB71328.1. AK096886 mRNA. Translation: BAC04884.1. Different initiation. BC058825 mRNA. Translation: AAH58825.1. Sequence problems. BC070130 mRNA. Translation: AAH70130.1. Sequence problems. U96486 Genomic DNA. Translation: AAC51786.1. AF542553 mRNA. Translation: AAQ09536.1. Different initiation.
IPI	IPI00398162. IPI00478974. IPI00745227. IPI00786896.
RefSeq	NP_001248392.1. NM_001261463.1. NP_006166.3. NM_006175.4. NP_932326.2. NM_198060.3.
UniGene	Hs.268788.
3D structure databases
ProteinModelPortal	Q86VF7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VF7. 1 interaction.
MINT	MINT-4726323.
PTM databases
PhosphoSite	Q86VF7.
Polymorphism databases
DMDM	115502505.
Proteomic databases
PaxDb	Q86VF7.
PRIDE	Q86VF7.
Protocols and materials databases
DNASU	4892.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359988; ENSP00000353078; ENSG00000197893. ENST00000360478; ENSP00000353666; ENSG00000197893. ENST00000369358; ENSP00000358365; ENSG00000197893. ENST00000369360; ENSP00000358367; ENSG00000197893.
GeneID	4892.
KEGG	hsa:4892.
UCSC	uc001laj.3. human. uc001lak.3. human.
Organism-specific databases
CTD	4892.
GeneCards	GC10M115338.
H-InvDB	HIX0009218.
HGNC	HGNC:7988. NRAP.
HPA	HPA037954.
MIM	602873. gene.
neXtProt	NX_Q86VF7.
PharmGKB	PA31767.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG262357.
HOVERGEN	HBG052905.
OMA	WMKGVGW.
PhylomeDB	Q86VF7.
Gene expression databases
ArrayExpress	Q86VF7.
Bgee	Q86VF7.
Genevestigator	Q86VF7.
GermOnline	ENSG00000197893. Homo sapiens.
Family and domain databases
Gene3D	2.10.110.10. 1 hit.
InterPro	IPR013998. Nebulin. IPR000900. Nebulin_35r-motif. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00412. LIM. 1 hit. PF00880. Nebulin. 19 hits. [Graphical view]
PRINTS	PR00510. NEBULIN.
SMART	SM00132. LIM. 1 hit. SM00227. NEBU. 41 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 1 hit. PS50023. LIM_DOMAIN_2. 1 hit. PS51216. NEBULIN. 44 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4892.
NextBio	18829.
SOURCE	Search...

Entry information

Entry name

NRAP_HUMAN

Accession

Primary (citable) accession number: Q86VF7
Secondary accession number(s): O15500 , Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	May 29, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.