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Q86VF7

- NRAP_HUMAN

UniProt

Q86VF7 - NRAP_HUMAN

Protein

Nebulin-related-anchoring protein

Gene

NRAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.By similarity

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. muscle alpha-actinin binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Actin-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nebulin-related-anchoring protein
    Short name:
    N-RAP
    Gene namesi
    Name:NRAPImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:7988. NRAP.

    Subcellular locationi


    Note: Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle.1 Publication

    GO - Cellular componenti

    1. fascia adherens Source: UniProtKB
    2. muscle tendon junction Source: UniProtKB
    3. myofibril Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31767.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17301730Nebulin-related-anchoring proteinPRO_0000250425Add
    BLAST

    Proteomic databases

    PaxDbiQ86VF7.
    PRIDEiQ86VF7.

    PTM databases

    PhosphoSiteiQ86VF7.

    Expressioni

    Tissue specificityi

    Expressed in cardiac and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ86VF7.
    GenevestigatoriQ86VF7.

    Organism-specific databases

    HPAiHPA037953.
    HPA037954.

    Interactioni

    Subunit structurei

    Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL.By similarity

    Protein-protein interaction databases

    BioGridi110951. 4 interactions.
    IntActiQ86VF7. 1 interaction.
    MINTiMINT-4726323.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VF7.
    SMRiQ86VF7. Positions 6-55.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 6461LIM zinc-bindingPROSITE-ProRule annotationAdd
    BLAST
    Repeati63 – 9735Nebulin 1Sequence AnalysisAdd
    BLAST
    Repeati156 – 16611Nebulin 2Sequence AnalysisAdd
    BLAST
    Repeati175 – 20228Nebulin 3Sequence AnalysisAdd
    BLAST
    Repeati203 – 23735Nebulin 4Sequence AnalysisAdd
    BLAST
    Repeati246 – 27328Nebulin 5Sequence AnalysisAdd
    BLAST
    Repeati298 – 30710Nebulin 6Sequence Analysis
    Repeati316 – 34328Nebulin 7Sequence AnalysisAdd
    BLAST
    Repeati348 – 38235Nebulin 8Sequence AnalysisAdd
    BLAST
    Repeati389 – 41729Nebulin 9Sequence AnalysisAdd
    BLAST
    Repeati419 – 45335Nebulin 10Sequence AnalysisAdd
    BLAST
    Repeati487 – 52135Nebulin 11Sequence AnalysisAdd
    BLAST
    Repeati522 – 55635Nebulin 12Sequence AnalysisAdd
    BLAST
    Repeati558 – 59235Nebulin 13Sequence AnalysisAdd
    BLAST
    Repeati602 – 62625Nebulin 14Sequence AnalysisAdd
    BLAST
    Repeati627 – 66135Nebulin 15Sequence AnalysisAdd
    BLAST
    Repeati662 – 69231Nebulin 16Sequence AnalysisAdd
    BLAST
    Repeati702 – 72423Nebulin 17Sequence AnalysisAdd
    BLAST
    Repeati726 – 76035Nebulin 18Sequence AnalysisAdd
    BLAST
    Repeati761 – 79535Nebulin 19Sequence AnalysisAdd
    BLAST
    Repeati797 – 83135Nebulin 20Sequence AnalysisAdd
    BLAST
    Repeati844 – 86926Nebulin 21Sequence AnalysisAdd
    BLAST
    Repeati870 – 89627Nebulin 22Sequence AnalysisAdd
    BLAST
    Repeati901 – 93535Nebulin 23Sequence AnalysisAdd
    BLAST
    Repeati945 – 96319Nebulin 24Sequence AnalysisAdd
    BLAST
    Repeati969 – 100335Nebulin 25Sequence AnalysisAdd
    BLAST
    Repeati1004 – 103835Nebulin 26Sequence AnalysisAdd
    BLAST
    Repeati1040 – 107435Nebulin 27Sequence AnalysisAdd
    BLAST
    Repeati1078 – 111235Nebulin 28Sequence AnalysisAdd
    BLAST
    Repeati1113 – 113927Nebulin 29Sequence AnalysisAdd
    BLAST
    Repeati1144 – 117835Nebulin 30Sequence AnalysisAdd
    BLAST
    Repeati1183 – 120624Nebulin 31Sequence AnalysisAdd
    BLAST
    Repeati1212 – 124635Nebulin 32Sequence AnalysisAdd
    BLAST
    Repeati1247 – 128135Nebulin 33Sequence AnalysisAdd
    BLAST
    Repeati1283 – 131735Nebulin 34Sequence AnalysisAdd
    BLAST
    Repeati1321 – 135535Nebulin 35Sequence AnalysisAdd
    BLAST
    Repeati1356 – 139035Nebulin 36Sequence AnalysisAdd
    BLAST
    Repeati1391 – 142131Nebulin 37Sequence AnalysisAdd
    BLAST
    Repeati1429 – 144921Nebulin 38Sequence AnalysisAdd
    BLAST
    Repeati1455 – 148127Nebulin 39Sequence AnalysisAdd
    BLAST
    Repeati1490 – 152435Nebulin 40Sequence AnalysisAdd
    BLAST
    Repeati1526 – 156035Nebulin 41Sequence AnalysisAdd
    BLAST
    Repeati1564 – 159835Nebulin 42Sequence AnalysisAdd
    BLAST
    Repeati1599 – 162628Nebulin 43Sequence AnalysisAdd
    BLAST
    Repeati1640 – 166425Nebulin 44Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
    Contains 44 nebulin repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG262357.
    HOVERGENiHBG052905.
    OMAiFHLPMDM.
    OrthoDBiEOG7GFB81.
    PhylomeDBiQ86VF7.
    TreeFamiTF313758.

    Family and domain databases

    Gene3Di2.10.110.10. 1 hit.
    InterProiIPR013998. Nebulin.
    IPR000900. Nebulin_repeat.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 1 hit.
    PF00880. Nebulin. 19 hits.
    [Graphical view]
    PRINTSiPR00510. NEBULIN.
    SMARTiSM00132. LIM. 1 hit.
    SM00227. NEBU. 41 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.
    PS51216. NEBULIN. 44 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q86VF7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK     50
    KPYCHAHNPK NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH 100
    WDMKSKDKEG APNRQPLANE RAYWTGYGEG NAWCPGALPD PEIVRMVEAR 150
    KSLGEEYTED YEQPRGKGSF PAMITPAYQR AKKANQLASQ VEYKRGHDER 200
    ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS FPAMITPAYQ 250
    IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE 300
    EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL 350
    PAQDNLVLKQ AQSVNKLVSE VEYKKDLESS RGHSINYCET PQFRNVSKIS 400
    KFTSDNKYKE NYQNHMRGRY EGVGMDRRTL HAMKVGSLAS NVAYKADYKH 450
    DIVDYNYPAT LTPSYQTAMK LVPLKDANYR QSIDKLKYSS VTDTPQIVQA 500
    KINAQQLSHV NYRADYEKNK LNYTLPQDVP QLVKAKTNAK LFSEVKYKEG 550
    WEKTKGKGFE MKLDAMSLLA AKASGELASN IKYKEEYEKT KGKAMGTADS 600
    RLLHSLQIAK MSSEVEYKKG FEESKTRFHL PMDMVNIRHA KKAQTLASDL 650
    DYRKKLHEYT VLPEDMKTQW AKKAYGLQSE LQYKADLAWM KGVGWLTEGS 700
    LNLEQAKKAG QLVSEKNYRQ RVDELKFTSV TDSSQMEHAK KSQELQSGVA 750
    YKAGNEQSVH QYTISKDEPL FLQARANAAN LSEKLYKSSW ENQKAKGFEL 800
    RLDSLTFLAA KAKRDLASEV KYKEDYERSR GKLIGAKDVQ GDSQMSHSLQ 850
    MSKLQSELEY KKGFEDTKSQ CHVSLDMVHL VHARKAQHLA TDVGYKTAEH 900
    HFTALPTDMK VEWAKKAYGL QSDNQYRADV KWMKGMGWVA TGSLNVEQAK 950
    KAGELISEKK YRQHPDALKF TSIKDTPEMV QARISYTQAV DRLYREQGEN 1000
    IKHHYTPTAD LPEVLLAKLN AMNISETRYK ESWSKLRDGG YKLRLDALPF 1050
    QAAKASGEII SDYKYKEAFE KMKGQMLGSR SLEDDISLAH SVYATSLQSD 1100
    VNYKKGFEHS KAQFHLPLDM AALVHAKKAQ TLASNQDYKH PLPQYTSLAE 1150
    DLRLSCAKKA HKLQSENLYR SDLNFMRGVA CVIPGTLEIE GRKKASELIS 1200
    ESKYRQHPHS FKYTAVTDTP NLLHAKFSNQ ITNERLYKAA GEDARHEYTM 1250
    TLGLPEFIRA KTNAANLSDA RYKESWRNLR AQGYKLTIEA LPFQAARASG 1300
    DIASDFLYRH DFVKERGKLI GPQSVRDDPR IQHCRRMGQL QSELQYRRGA 1350
    TSSQAQFHLP MDMVHLVHAK NAQALASDHD YRTQYHKFTA LPEDLKMAWA 1400
    KKAHALQSEL RYKSDLIGMK GIGWLALRSP QMESAKKAGE LISETKYRKK 1450
    PDSIKFTTVV DSPDLVHAKN SYMHCNERMY RSGDAESLHR YTLIPDHPDF 1500
    TRARLNALHL SDKVYRNSWE QTRAGSYDFR LDAIPFQTAR ASREIASDFR 1550
    YKEAFLRDRG LQIGYRSVDD DPRMKHFLNV GRLQSDNEYK KDFAKSRSQF 1600
    HSSTDQPGLL QAKRSQQLAS DVHYRQPLPQ PTCDPEQLGL RHAQKAHQLQ 1650
    SDVKYKSDLN LTRGVGWTPP GSYKVEMARR AAELANARGL GLQGAYRGAE 1700
    AVEAGDHQSG EVNPDATEIL HVKKKKALLL 1730
    Length:1,730
    Mass (Da):197,074
    Last modified:October 3, 2006 - v2
    Checksum:i2F6AD0C7C07EC797
    GO
    Isoform 21 Publication (identifier: Q86VF7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         580-580: N → NVHLLLSLK

    Note: Gene prediction based on EST data.Curated

    Show »
    Length:1,738
    Mass (Da):197,978
    Checksum:iD6A39759359FB9BF
    GO
    Isoform 31 Publication (identifier: Q86VF7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         371-405: Missing.
         580-580: N → NVHLLLSLK

    Note: Gene prediction based on EST data.Curated

    Show »
    Length:1,703
    Mass (Da):193,902
    Checksum:iE7FA287C6611A0CD
    GO
    Isoform 42 Publications (identifier: Q86VF7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         371-405: Missing.

    Show »
    Length:1,695
    Mass (Da):192,997
    Checksum:iFA5D00F9978B811A
    GO

    Sequence cautioni

    The sequence AAH58825.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH70130.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAQ09536.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC04884.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti224 – 2241S → N in CAD38623. (PubMed:17974005)Curated
    Sequence conflicti261 – 2611D → G in CAD89910. (PubMed:17974005)Curated
    Sequence conflicti338 – 3381F → S in CAE45846. (PubMed:17974005)Curated
    Sequence conflicti395 – 3951N → D in CAD38623. (PubMed:17974005)Curated
    Sequence conflicti488 – 4881Y → H in CAE45811. (PubMed:17974005)Curated
    Sequence conflicti545 – 5451V → A in BAB71328. (PubMed:14702039)Curated
    Sequence conflicti658 – 6581E → G in CAD89910. (PubMed:17974005)Curated
    Sequence conflicti862 – 8621K → E in CAD89910. (PubMed:17974005)Curated
    Sequence conflicti862 – 8621K → E in CAE45846. (PubMed:17974005)Curated
    Sequence conflicti1210 – 12101S → P in CAE45846. (PubMed:17974005)Curated
    Sequence conflicti1236 – 12361L → F in CAD89910. (PubMed:17974005)Curated
    Sequence conflicti1260 – 12601A → V in CAE45846. (PubMed:17974005)Curated
    Sequence conflicti1348 – 13481R → K in CAE45846. (PubMed:17974005)Curated
    Sequence conflicti1357 – 13571F → L in CAD89899. (PubMed:17974005)Curated
    Sequence conflicti1414 – 14141S → L in CAE45846. (PubMed:17974005)Curated
    Sequence conflicti1563 – 15631I → V in CAD89910. (PubMed:17974005)Curated
    Sequence conflicti1607 – 16071P → H in CAD89910. (PubMed:17974005)Curated
    Sequence conflicti1672 – 16721S → P in CAD38623. (PubMed:17974005)Curated
    Sequence conflicti1696 – 16961Y → YQ in CAD89910. (PubMed:17974005)Curated
    Sequence conflicti1696 – 16961Y → YQ in CAD89998. (PubMed:17974005)Curated
    Sequence conflicti1696 – 16961Y → YQ(PubMed:15164054)Curated
    Sequence conflicti1697 – 16971R → Q in CAD89899. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti132 – 1321A → S.
    Corresponds to variant rs34700024 [ dbSNP | Ensembl ].
    VAR_034073
    Natural varianti186 – 1861Q → E.
    Corresponds to variant rs35049661 [ dbSNP | Ensembl ].
    VAR_034074
    Natural varianti208 – 2081V → A.4 Publications
    Corresponds to variant rs2154028 [ dbSNP | Ensembl ].
    VAR_027556
    Natural varianti249 – 2491Y → C.1 Publication
    Corresponds to variant rs2185913 [ dbSNP | Ensembl ].
    VAR_027557
    Natural varianti282 – 2821A → T.
    Corresponds to variant rs2275799 [ dbSNP | Ensembl ].
    VAR_034075
    Natural varianti344 – 3441A → T.3 Publications
    Corresponds to variant rs3121478 [ dbSNP | Ensembl ].
    VAR_027558
    Natural varianti360 – 3601Q → R.3 Publications
    Corresponds to variant rs3127106 [ dbSNP | Ensembl ].
    VAR_027559
    Natural varianti484 – 4841D → N.
    Corresponds to variant rs11196400 [ dbSNP | Ensembl ].
    VAR_050160
    Natural varianti490 – 4901S → L.2 Publications
    Corresponds to variant rs3189030 [ dbSNP | Ensembl ].
    VAR_034076
    Natural varianti519 – 5191N → I.
    Corresponds to variant rs2270182 [ dbSNP | Ensembl ].
    VAR_034077
    Natural varianti647 – 6471A → S.
    Corresponds to variant rs2286734 [ dbSNP | Ensembl ].
    VAR_050161
    Natural varianti674 – 6741A → V.1 Publication
    Corresponds to variant rs2286735 [ dbSNP | Ensembl ].
    VAR_034078
    Natural varianti884 – 8841R → C.1 Publication
    Corresponds to variant rs868738 [ dbSNP | Ensembl ].
    VAR_034079
    Natural varianti1022 – 10221M → V.
    Corresponds to variant rs34523503 [ dbSNP | Ensembl ].
    VAR_061357
    Natural varianti1112 – 11121A → V.1 Publication
    Corresponds to variant rs1539587 [ dbSNP | Ensembl ].
    VAR_034080
    Natural varianti1183 – 11831I → V.2 Publications
    Corresponds to variant rs10749138 [ dbSNP | Ensembl ].
    VAR_050162
    Natural varianti1531 – 15311L → P.1 Publication
    Corresponds to variant rs11196389 [ dbSNP | Ensembl ].
    VAR_027560
    Natural varianti1566 – 15661R → C.1 Publication
    Corresponds to variant rs1885434 [ dbSNP | Ensembl ].
    VAR_050163
    Natural varianti1569 – 15691D → N.
    Corresponds to variant rs11575798 [ dbSNP | Ensembl ].
    VAR_050164
    Natural varianti1643 – 16431A → S.
    Corresponds to variant rs11575797 [ dbSNP | Ensembl ].
    VAR_050165

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei371 – 40535Missing in isoform 3 and isoform 4. 3 PublicationsVSP_052165Add
    BLAST
    Alternative sequencei580 – 5801N → NVHLLLSLK in isoform 2 and isoform 3. 1 PublicationVSP_052166

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY177620 mRNA. Translation: AAO47073.1.
    AY177621 mRNA. Translation: AAO47074.1.
    AY081943 mRNA. Translation: AAL99185.2.
    AL831980 mRNA. Translation: CAD89899.1.
    AL832025 mRNA. Translation: CAD89910.1.
    AL832330 mRNA. Translation: CAD38623.1.
    AL832457 mRNA. Translation: CAD89998.1.
    BX640682 mRNA. Translation: CAE45811.1.
    BX640730 mRNA. Translation: CAE45846.1.
    BX641052 mRNA. Translation: CAE46027.1.
    AL390197 Genomic DNA. Translation: CAH71110.1.
    AL390197 Genomic DNA. Translation: CAH71111.1.
    AK056969 mRNA. Translation: BAB71328.1.
    AK096886 mRNA. Translation: BAC04884.1. Different initiation.
    BC058825 mRNA. Translation: AAH58825.1. Sequence problems.
    BC070130 mRNA. Translation: AAH70130.1. Sequence problems.
    U96486 Genomic DNA. Translation: AAC51786.1.
    AF542553 mRNA. Translation: AAQ09536.1. Different initiation.
    CCDSiCCDS7578.1. [Q86VF7-4]
    CCDS7579.1. [Q86VF7-1]
    RefSeqiNP_001248392.1. NM_001261463.1.
    NP_006166.3. NM_006175.4. [Q86VF7-4]
    NP_932326.2. NM_198060.3. [Q86VF7-1]
    UniGeneiHs.268788.

    Genome annotation databases

    EnsembliENST00000359988; ENSP00000353078; ENSG00000197893. [Q86VF7-1]
    ENST00000360478; ENSP00000353666; ENSG00000197893. [Q86VF7-4]
    ENST00000369358; ENSP00000358365; ENSG00000197893. [Q86VF7-2]
    ENST00000369360; ENSP00000358367; ENSG00000197893. [Q86VF7-3]
    GeneIDi4892.
    KEGGihsa:4892.
    UCSCiuc001laj.4. human. [Q86VF7-1]
    uc001lak.4. human. [Q86VF7-4]

    Polymorphism databases

    DMDMi115502505.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY177620 mRNA. Translation: AAO47073.1 .
    AY177621 mRNA. Translation: AAO47074.1 .
    AY081943 mRNA. Translation: AAL99185.2 .
    AL831980 mRNA. Translation: CAD89899.1 .
    AL832025 mRNA. Translation: CAD89910.1 .
    AL832330 mRNA. Translation: CAD38623.1 .
    AL832457 mRNA. Translation: CAD89998.1 .
    BX640682 mRNA. Translation: CAE45811.1 .
    BX640730 mRNA. Translation: CAE45846.1 .
    BX641052 mRNA. Translation: CAE46027.1 .
    AL390197 Genomic DNA. Translation: CAH71110.1 .
    AL390197 Genomic DNA. Translation: CAH71111.1 .
    AK056969 mRNA. Translation: BAB71328.1 .
    AK096886 mRNA. Translation: BAC04884.1 . Different initiation.
    BC058825 mRNA. Translation: AAH58825.1 . Sequence problems.
    BC070130 mRNA. Translation: AAH70130.1 . Sequence problems.
    U96486 Genomic DNA. Translation: AAC51786.1 .
    AF542553 mRNA. Translation: AAQ09536.1 . Different initiation.
    CCDSi CCDS7578.1. [Q86VF7-4 ]
    CCDS7579.1. [Q86VF7-1 ]
    RefSeqi NP_001248392.1. NM_001261463.1.
    NP_006166.3. NM_006175.4. [Q86VF7-4 ]
    NP_932326.2. NM_198060.3. [Q86VF7-1 ]
    UniGenei Hs.268788.

    3D structure databases

    ProteinModelPortali Q86VF7.
    SMRi Q86VF7. Positions 6-55.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110951. 4 interactions.
    IntActi Q86VF7. 1 interaction.
    MINTi MINT-4726323.

    PTM databases

    PhosphoSitei Q86VF7.

    Polymorphism databases

    DMDMi 115502505.

    Proteomic databases

    PaxDbi Q86VF7.
    PRIDEi Q86VF7.

    Protocols and materials databases

    DNASUi 4892.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359988 ; ENSP00000353078 ; ENSG00000197893 . [Q86VF7-1 ]
    ENST00000360478 ; ENSP00000353666 ; ENSG00000197893 . [Q86VF7-4 ]
    ENST00000369358 ; ENSP00000358365 ; ENSG00000197893 . [Q86VF7-2 ]
    ENST00000369360 ; ENSP00000358367 ; ENSG00000197893 . [Q86VF7-3 ]
    GeneIDi 4892.
    KEGGi hsa:4892.
    UCSCi uc001laj.4. human. [Q86VF7-1 ]
    uc001lak.4. human. [Q86VF7-4 ]

    Organism-specific databases

    CTDi 4892.
    GeneCardsi GC10M115338.
    H-InvDB HIX0009218.
    HGNCi HGNC:7988. NRAP.
    HPAi HPA037953.
    HPA037954.
    MIMi 602873. gene.
    neXtProti NX_Q86VF7.
    PharmGKBi PA31767.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262357.
    HOVERGENi HBG052905.
    OMAi FHLPMDM.
    OrthoDBi EOG7GFB81.
    PhylomeDBi Q86VF7.
    TreeFami TF313758.

    Miscellaneous databases

    GeneWikii NRAP.
    GenomeRNAii 4892.
    NextBioi 18829.
    PROi Q86VF7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86VF7.
    Genevestigatori Q86VF7.

    Family and domain databases

    Gene3Di 2.10.110.10. 1 hit.
    InterProi IPR013998. Nebulin.
    IPR000900. Nebulin_repeat.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 1 hit.
    PF00880. Nebulin. 19 hits.
    [Graphical view ]
    PRINTSi PR00510. NEBULIN.
    SMARTi SM00132. LIM. 1 hit.
    SM00227. NEBU. 41 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.
    PS51216. NEBULIN. 44 hits.
    [Graphical view ]
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    Publicationsi

    1. "Genomic organization, alternative splicing, and expression of human and mouse N-RAP, a nebulin-related LIM protein of striated muscle."
      Mohiddin S.A., Lu S., Cardoso J.-P., Carroll S., Jha S., Horowits R., Fananapazir L.
      Cell Motil. Cytoskeleton 55:200-212(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT VAL-1183.
    2. "Human Nrap, a novel gene which interact with actin."
      Yuan H.F., Wang X., Wang D.M., Li H.M., Feng K., Bai C.X., Zhang R., Chen L., Li Y.H., Gao Y.H., Zhen M., Yue W., Xie C., Xie X.Y., Niu L.L., Gao W.J., Zhang J., Cao H., Pei X.T.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS ALA-208; THR-344; ARG-360 AND VAL-674.
      Tissue: Skeletal muscleImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-208; CYS-249; THR-344; ARG-360; LEU-490; CYS-884; VAL-1112; VAL-1183; PRO-1531 AND CYS-1566.
      Tissue: Skeletal muscle.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-490.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-580 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1311-1730 (ISOFORM 1), VARIANTS ALA-208; THR-344 AND ARG-360.
      Tissue: Skeletal muscleImported.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-270 (ISOFORM 1), VARIANT ALA-208.
      Tissue: Skeletal muscleImported.
    7. "Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes."
      Luo G., Leroy E., Kozak C.A., Polymeropoulos M.H., Horowits R.
      Genomics 45:229-232(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1004-1080 (ISOFORM 1).
    8. "Cloning and characterization of a novel human gene encoding a protein of 394 amino acids with significant motif of nebulin signature IV and nebulin repeat."
      Zhang D.L., Cai J.J., Ma D.L.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1314-1730 (ISOFORM 1).

    Entry informationi

    Entry nameiNRAP_HUMAN
    AccessioniPrimary (citable) accession number: Q86VF7
    Secondary accession number(s): O15500
    , Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3