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Q86VF7

- NRAP_HUMAN

UniProt

Q86VF7 - NRAP_HUMAN

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Protein

Nebulin-related-anchoring protein

Gene

NRAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.By similarity

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. muscle alpha-actinin binding Source: UniProtKB
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nebulin-related-anchoring protein
Short name:
N-RAP
Gene namesi
Name:NRAPImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:7988. NRAP.

Subcellular locationi


Note: Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle.1 Publication

GO - Cellular componenti

  1. fascia adherens Source: UniProtKB
  2. muscle tendon junction Source: UniProtKB
  3. myofibril Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31767.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17301730Nebulin-related-anchoring proteinPRO_0000250425Add
BLAST

Proteomic databases

PaxDbiQ86VF7.
PRIDEiQ86VF7.

PTM databases

PhosphoSiteiQ86VF7.

Expressioni

Tissue specificityi

Expressed in cardiac and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ86VF7.
GenevestigatoriQ86VF7.

Organism-specific databases

HPAiHPA037953.
HPA037954.

Interactioni

Subunit structurei

Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL.By similarity

Protein-protein interaction databases

BioGridi110951. 4 interactions.
IntActiQ86VF7. 1 interaction.
MINTiMINT-4726323.

Structurei

3D structure databases

ProteinModelPortaliQ86VF7.
SMRiQ86VF7. Positions 6-55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6461LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST
Repeati63 – 9735Nebulin 1Sequence AnalysisAdd
BLAST
Repeati156 – 16611Nebulin 2Sequence AnalysisAdd
BLAST
Repeati175 – 20228Nebulin 3Sequence AnalysisAdd
BLAST
Repeati203 – 23735Nebulin 4Sequence AnalysisAdd
BLAST
Repeati246 – 27328Nebulin 5Sequence AnalysisAdd
BLAST
Repeati298 – 30710Nebulin 6Sequence Analysis
Repeati316 – 34328Nebulin 7Sequence AnalysisAdd
BLAST
Repeati348 – 38235Nebulin 8Sequence AnalysisAdd
BLAST
Repeati389 – 41729Nebulin 9Sequence AnalysisAdd
BLAST
Repeati419 – 45335Nebulin 10Sequence AnalysisAdd
BLAST
Repeati487 – 52135Nebulin 11Sequence AnalysisAdd
BLAST
Repeati522 – 55635Nebulin 12Sequence AnalysisAdd
BLAST
Repeati558 – 59235Nebulin 13Sequence AnalysisAdd
BLAST
Repeati602 – 62625Nebulin 14Sequence AnalysisAdd
BLAST
Repeati627 – 66135Nebulin 15Sequence AnalysisAdd
BLAST
Repeati662 – 69231Nebulin 16Sequence AnalysisAdd
BLAST
Repeati702 – 72423Nebulin 17Sequence AnalysisAdd
BLAST
Repeati726 – 76035Nebulin 18Sequence AnalysisAdd
BLAST
Repeati761 – 79535Nebulin 19Sequence AnalysisAdd
BLAST
Repeati797 – 83135Nebulin 20Sequence AnalysisAdd
BLAST
Repeati844 – 86926Nebulin 21Sequence AnalysisAdd
BLAST
Repeati870 – 89627Nebulin 22Sequence AnalysisAdd
BLAST
Repeati901 – 93535Nebulin 23Sequence AnalysisAdd
BLAST
Repeati945 – 96319Nebulin 24Sequence AnalysisAdd
BLAST
Repeati969 – 100335Nebulin 25Sequence AnalysisAdd
BLAST
Repeati1004 – 103835Nebulin 26Sequence AnalysisAdd
BLAST
Repeati1040 – 107435Nebulin 27Sequence AnalysisAdd
BLAST
Repeati1078 – 111235Nebulin 28Sequence AnalysisAdd
BLAST
Repeati1113 – 113927Nebulin 29Sequence AnalysisAdd
BLAST
Repeati1144 – 117835Nebulin 30Sequence AnalysisAdd
BLAST
Repeati1183 – 120624Nebulin 31Sequence AnalysisAdd
BLAST
Repeati1212 – 124635Nebulin 32Sequence AnalysisAdd
BLAST
Repeati1247 – 128135Nebulin 33Sequence AnalysisAdd
BLAST
Repeati1283 – 131735Nebulin 34Sequence AnalysisAdd
BLAST
Repeati1321 – 135535Nebulin 35Sequence AnalysisAdd
BLAST
Repeati1356 – 139035Nebulin 36Sequence AnalysisAdd
BLAST
Repeati1391 – 142131Nebulin 37Sequence AnalysisAdd
BLAST
Repeati1429 – 144921Nebulin 38Sequence AnalysisAdd
BLAST
Repeati1455 – 148127Nebulin 39Sequence AnalysisAdd
BLAST
Repeati1490 – 152435Nebulin 40Sequence AnalysisAdd
BLAST
Repeati1526 – 156035Nebulin 41Sequence AnalysisAdd
BLAST
Repeati1564 – 159835Nebulin 42Sequence AnalysisAdd
BLAST
Repeati1599 – 162628Nebulin 43Sequence AnalysisAdd
BLAST
Repeati1640 – 166425Nebulin 44Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
Contains 44 nebulin repeats.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG262357.
GeneTreeiENSGT00530000062924.
HOVERGENiHBG052905.
InParanoidiQ86VF7.
OMAiFHLPMDM.
OrthoDBiEOG7GFB81.
PhylomeDBiQ86VF7.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR013998. Nebulin.
IPR000900. Nebulin_repeat.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 1 hit.
PF00880. Nebulin. 19 hits.
[Graphical view]
PRINTSiPR00510. NEBULIN.
SMARTiSM00132. LIM. 1 hit.
SM00227. NEBU. 41 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS51216. NEBULIN. 44 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q86VF7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK
60 70 80 90 100
KPYCHAHNPK NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH
110 120 130 140 150
WDMKSKDKEG APNRQPLANE RAYWTGYGEG NAWCPGALPD PEIVRMVEAR
160 170 180 190 200
KSLGEEYTED YEQPRGKGSF PAMITPAYQR AKKANQLASQ VEYKRGHDER
210 220 230 240 250
ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS FPAMITPAYQ
260 270 280 290 300
IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE
310 320 330 340 350
EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL
360 370 380 390 400
PAQDNLVLKQ AQSVNKLVSE VEYKKDLESS RGHSINYCET PQFRNVSKIS
410 420 430 440 450
KFTSDNKYKE NYQNHMRGRY EGVGMDRRTL HAMKVGSLAS NVAYKADYKH
460 470 480 490 500
DIVDYNYPAT LTPSYQTAMK LVPLKDANYR QSIDKLKYSS VTDTPQIVQA
510 520 530 540 550
KINAQQLSHV NYRADYEKNK LNYTLPQDVP QLVKAKTNAK LFSEVKYKEG
560 570 580 590 600
WEKTKGKGFE MKLDAMSLLA AKASGELASN IKYKEEYEKT KGKAMGTADS
610 620 630 640 650
RLLHSLQIAK MSSEVEYKKG FEESKTRFHL PMDMVNIRHA KKAQTLASDL
660 670 680 690 700
DYRKKLHEYT VLPEDMKTQW AKKAYGLQSE LQYKADLAWM KGVGWLTEGS
710 720 730 740 750
LNLEQAKKAG QLVSEKNYRQ RVDELKFTSV TDSSQMEHAK KSQELQSGVA
760 770 780 790 800
YKAGNEQSVH QYTISKDEPL FLQARANAAN LSEKLYKSSW ENQKAKGFEL
810 820 830 840 850
RLDSLTFLAA KAKRDLASEV KYKEDYERSR GKLIGAKDVQ GDSQMSHSLQ
860 870 880 890 900
MSKLQSELEY KKGFEDTKSQ CHVSLDMVHL VHARKAQHLA TDVGYKTAEH
910 920 930 940 950
HFTALPTDMK VEWAKKAYGL QSDNQYRADV KWMKGMGWVA TGSLNVEQAK
960 970 980 990 1000
KAGELISEKK YRQHPDALKF TSIKDTPEMV QARISYTQAV DRLYREQGEN
1010 1020 1030 1040 1050
IKHHYTPTAD LPEVLLAKLN AMNISETRYK ESWSKLRDGG YKLRLDALPF
1060 1070 1080 1090 1100
QAAKASGEII SDYKYKEAFE KMKGQMLGSR SLEDDISLAH SVYATSLQSD
1110 1120 1130 1140 1150
VNYKKGFEHS KAQFHLPLDM AALVHAKKAQ TLASNQDYKH PLPQYTSLAE
1160 1170 1180 1190 1200
DLRLSCAKKA HKLQSENLYR SDLNFMRGVA CVIPGTLEIE GRKKASELIS
1210 1220 1230 1240 1250
ESKYRQHPHS FKYTAVTDTP NLLHAKFSNQ ITNERLYKAA GEDARHEYTM
1260 1270 1280 1290 1300
TLGLPEFIRA KTNAANLSDA RYKESWRNLR AQGYKLTIEA LPFQAARASG
1310 1320 1330 1340 1350
DIASDFLYRH DFVKERGKLI GPQSVRDDPR IQHCRRMGQL QSELQYRRGA
1360 1370 1380 1390 1400
TSSQAQFHLP MDMVHLVHAK NAQALASDHD YRTQYHKFTA LPEDLKMAWA
1410 1420 1430 1440 1450
KKAHALQSEL RYKSDLIGMK GIGWLALRSP QMESAKKAGE LISETKYRKK
1460 1470 1480 1490 1500
PDSIKFTTVV DSPDLVHAKN SYMHCNERMY RSGDAESLHR YTLIPDHPDF
1510 1520 1530 1540 1550
TRARLNALHL SDKVYRNSWE QTRAGSYDFR LDAIPFQTAR ASREIASDFR
1560 1570 1580 1590 1600
YKEAFLRDRG LQIGYRSVDD DPRMKHFLNV GRLQSDNEYK KDFAKSRSQF
1610 1620 1630 1640 1650
HSSTDQPGLL QAKRSQQLAS DVHYRQPLPQ PTCDPEQLGL RHAQKAHQLQ
1660 1670 1680 1690 1700
SDVKYKSDLN LTRGVGWTPP GSYKVEMARR AAELANARGL GLQGAYRGAE
1710 1720 1730
AVEAGDHQSG EVNPDATEIL HVKKKKALLL
Length:1,730
Mass (Da):197,074
Last modified:October 3, 2006 - v2
Checksum:i2F6AD0C7C07EC797
GO
Isoform 21 Publication (identifier: Q86VF7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-580: N → NVHLLLSLK

Note: Gene prediction based on EST data.Curated

Show »
Length:1,738
Mass (Da):197,978
Checksum:iD6A39759359FB9BF
GO
Isoform 31 Publication (identifier: Q86VF7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.
     580-580: N → NVHLLLSLK

Note: Gene prediction based on EST data.Curated

Show »
Length:1,703
Mass (Da):193,902
Checksum:iE7FA287C6611A0CD
GO
Isoform 42 Publications (identifier: Q86VF7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.

Show »
Length:1,695
Mass (Da):192,997
Checksum:iFA5D00F9978B811A
GO

Sequence cautioni

The sequence AAH58825.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH70130.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAQ09536.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC04884.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241S → N in CAD38623. (PubMed:17974005)Curated
Sequence conflicti261 – 2611D → G in CAD89910. (PubMed:17974005)Curated
Sequence conflicti338 – 3381F → S in CAE45846. (PubMed:17974005)Curated
Sequence conflicti395 – 3951N → D in CAD38623. (PubMed:17974005)Curated
Sequence conflicti488 – 4881Y → H in CAE45811. (PubMed:17974005)Curated
Sequence conflicti545 – 5451V → A in BAB71328. (PubMed:14702039)Curated
Sequence conflicti658 – 6581E → G in CAD89910. (PubMed:17974005)Curated
Sequence conflicti862 – 8621K → E in CAD89910. (PubMed:17974005)Curated
Sequence conflicti862 – 8621K → E in CAE45846. (PubMed:17974005)Curated
Sequence conflicti1210 – 12101S → P in CAE45846. (PubMed:17974005)Curated
Sequence conflicti1236 – 12361L → F in CAD89910. (PubMed:17974005)Curated
Sequence conflicti1260 – 12601A → V in CAE45846. (PubMed:17974005)Curated
Sequence conflicti1348 – 13481R → K in CAE45846. (PubMed:17974005)Curated
Sequence conflicti1357 – 13571F → L in CAD89899. (PubMed:17974005)Curated
Sequence conflicti1414 – 14141S → L in CAE45846. (PubMed:17974005)Curated
Sequence conflicti1563 – 15631I → V in CAD89910. (PubMed:17974005)Curated
Sequence conflicti1607 – 16071P → H in CAD89910. (PubMed:17974005)Curated
Sequence conflicti1672 – 16721S → P in CAD38623. (PubMed:17974005)Curated
Sequence conflicti1696 – 16961Y → YQ in CAD89910. (PubMed:17974005)Curated
Sequence conflicti1696 – 16961Y → YQ in CAD89998. (PubMed:17974005)Curated
Sequence conflicti1696 – 16961Y → YQ(PubMed:15164054)Curated
Sequence conflicti1697 – 16971R → Q in CAD89899. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti132 – 1321A → S.
Corresponds to variant rs34700024 [ dbSNP | Ensembl ].
VAR_034073
Natural varianti186 – 1861Q → E.
Corresponds to variant rs35049661 [ dbSNP | Ensembl ].
VAR_034074
Natural varianti208 – 2081V → A.4 Publications
Corresponds to variant rs2154028 [ dbSNP | Ensembl ].
VAR_027556
Natural varianti249 – 2491Y → C.1 Publication
Corresponds to variant rs2185913 [ dbSNP | Ensembl ].
VAR_027557
Natural varianti282 – 2821A → T.
Corresponds to variant rs2275799 [ dbSNP | Ensembl ].
VAR_034075
Natural varianti344 – 3441A → T.3 Publications
Corresponds to variant rs3121478 [ dbSNP | Ensembl ].
VAR_027558
Natural varianti360 – 3601Q → R.3 Publications
Corresponds to variant rs3127106 [ dbSNP | Ensembl ].
VAR_027559
Natural varianti484 – 4841D → N.
Corresponds to variant rs11196400 [ dbSNP | Ensembl ].
VAR_050160
Natural varianti490 – 4901S → L.2 Publications
Corresponds to variant rs3189030 [ dbSNP | Ensembl ].
VAR_034076
Natural varianti519 – 5191N → I.
Corresponds to variant rs2270182 [ dbSNP | Ensembl ].
VAR_034077
Natural varianti647 – 6471A → S.
Corresponds to variant rs2286734 [ dbSNP | Ensembl ].
VAR_050161
Natural varianti674 – 6741A → V.1 Publication
Corresponds to variant rs2286735 [ dbSNP | Ensembl ].
VAR_034078
Natural varianti884 – 8841R → C.1 Publication
Corresponds to variant rs868738 [ dbSNP | Ensembl ].
VAR_034079
Natural varianti1022 – 10221M → V.
Corresponds to variant rs34523503 [ dbSNP | Ensembl ].
VAR_061357
Natural varianti1112 – 11121A → V.1 Publication
Corresponds to variant rs1539587 [ dbSNP | Ensembl ].
VAR_034080
Natural varianti1183 – 11831I → V.2 Publications
Corresponds to variant rs10749138 [ dbSNP | Ensembl ].
VAR_050162
Natural varianti1531 – 15311L → P.1 Publication
Corresponds to variant rs11196389 [ dbSNP | Ensembl ].
VAR_027560
Natural varianti1566 – 15661R → C.1 Publication
Corresponds to variant rs1885434 [ dbSNP | Ensembl ].
VAR_050163
Natural varianti1569 – 15691D → N.
Corresponds to variant rs11575798 [ dbSNP | Ensembl ].
VAR_050164
Natural varianti1643 – 16431A → S.
Corresponds to variant rs11575797 [ dbSNP | Ensembl ].
VAR_050165

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei371 – 40535Missing in isoform 3 and isoform 4. 3 PublicationsVSP_052165Add
BLAST
Alternative sequencei580 – 5801N → NVHLLLSLK in isoform 2 and isoform 3. 1 PublicationVSP_052166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177620 mRNA. Translation: AAO47073.1.
AY177621 mRNA. Translation: AAO47074.1.
AY081943 mRNA. Translation: AAL99185.2.
AL831980 mRNA. Translation: CAD89899.1.
AL832025 mRNA. Translation: CAD89910.1.
AL832330 mRNA. Translation: CAD38623.1.
AL832457 mRNA. Translation: CAD89998.1.
BX640682 mRNA. Translation: CAE45811.1.
BX640730 mRNA. Translation: CAE45846.1.
BX641052 mRNA. Translation: CAE46027.1.
AL390197 Genomic DNA. Translation: CAH71110.1.
AL390197 Genomic DNA. Translation: CAH71111.1.
AK056969 mRNA. Translation: BAB71328.1.
AK096886 mRNA. Translation: BAC04884.1. Different initiation.
BC058825 mRNA. Translation: AAH58825.1. Sequence problems.
BC070130 mRNA. Translation: AAH70130.1. Sequence problems.
U96486 Genomic DNA. Translation: AAC51786.1.
AF542553 mRNA. Translation: AAQ09536.1. Different initiation.
CCDSiCCDS7578.1. [Q86VF7-4]
CCDS7579.1. [Q86VF7-1]
RefSeqiNP_001248392.1. NM_001261463.1.
NP_006166.3. NM_006175.4. [Q86VF7-4]
NP_932326.2. NM_198060.3. [Q86VF7-1]
UniGeneiHs.268788.

Genome annotation databases

EnsembliENST00000359988; ENSP00000353078; ENSG00000197893. [Q86VF7-1]
ENST00000360478; ENSP00000353666; ENSG00000197893. [Q86VF7-4]
ENST00000369360; ENSP00000358367; ENSG00000197893. [Q86VF7-3]
GeneIDi4892.
KEGGihsa:4892.
UCSCiuc001laj.4. human. [Q86VF7-1]
uc001lak.4. human. [Q86VF7-4]

Polymorphism databases

DMDMi115502505.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177620 mRNA. Translation: AAO47073.1 .
AY177621 mRNA. Translation: AAO47074.1 .
AY081943 mRNA. Translation: AAL99185.2 .
AL831980 mRNA. Translation: CAD89899.1 .
AL832025 mRNA. Translation: CAD89910.1 .
AL832330 mRNA. Translation: CAD38623.1 .
AL832457 mRNA. Translation: CAD89998.1 .
BX640682 mRNA. Translation: CAE45811.1 .
BX640730 mRNA. Translation: CAE45846.1 .
BX641052 mRNA. Translation: CAE46027.1 .
AL390197 Genomic DNA. Translation: CAH71110.1 .
AL390197 Genomic DNA. Translation: CAH71111.1 .
AK056969 mRNA. Translation: BAB71328.1 .
AK096886 mRNA. Translation: BAC04884.1 . Different initiation.
BC058825 mRNA. Translation: AAH58825.1 . Sequence problems.
BC070130 mRNA. Translation: AAH70130.1 . Sequence problems.
U96486 Genomic DNA. Translation: AAC51786.1 .
AF542553 mRNA. Translation: AAQ09536.1 . Different initiation.
CCDSi CCDS7578.1. [Q86VF7-4 ]
CCDS7579.1. [Q86VF7-1 ]
RefSeqi NP_001248392.1. NM_001261463.1.
NP_006166.3. NM_006175.4. [Q86VF7-4 ]
NP_932326.2. NM_198060.3. [Q86VF7-1 ]
UniGenei Hs.268788.

3D structure databases

ProteinModelPortali Q86VF7.
SMRi Q86VF7. Positions 6-55.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110951. 4 interactions.
IntActi Q86VF7. 1 interaction.
MINTi MINT-4726323.

PTM databases

PhosphoSitei Q86VF7.

Polymorphism databases

DMDMi 115502505.

Proteomic databases

PaxDbi Q86VF7.
PRIDEi Q86VF7.

Protocols and materials databases

DNASUi 4892.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359988 ; ENSP00000353078 ; ENSG00000197893 . [Q86VF7-1 ]
ENST00000360478 ; ENSP00000353666 ; ENSG00000197893 . [Q86VF7-4 ]
ENST00000369360 ; ENSP00000358367 ; ENSG00000197893 . [Q86VF7-3 ]
GeneIDi 4892.
KEGGi hsa:4892.
UCSCi uc001laj.4. human. [Q86VF7-1 ]
uc001lak.4. human. [Q86VF7-4 ]

Organism-specific databases

CTDi 4892.
GeneCardsi GC10M115338.
H-InvDB HIX0009218.
HGNCi HGNC:7988. NRAP.
HPAi HPA037953.
HPA037954.
MIMi 602873. gene.
neXtProti NX_Q86VF7.
PharmGKBi PA31767.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262357.
GeneTreei ENSGT00530000062924.
HOVERGENi HBG052905.
InParanoidi Q86VF7.
OMAi FHLPMDM.
OrthoDBi EOG7GFB81.
PhylomeDBi Q86VF7.
TreeFami TF313758.

Miscellaneous databases

GeneWikii NRAP.
GenomeRNAii 4892.
NextBioi 18829.
PROi Q86VF7.
SOURCEi Search...

Gene expression databases

Bgeei Q86VF7.
Genevestigatori Q86VF7.

Family and domain databases

Gene3Di 2.10.110.10. 1 hit.
InterProi IPR013998. Nebulin.
IPR000900. Nebulin_repeat.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 1 hit.
PF00880. Nebulin. 19 hits.
[Graphical view ]
PRINTSi PR00510. NEBULIN.
SMARTi SM00132. LIM. 1 hit.
SM00227. NEBU. 41 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS51216. NEBULIN. 44 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization, alternative splicing, and expression of human and mouse N-RAP, a nebulin-related LIM protein of striated muscle."
    Mohiddin S.A., Lu S., Cardoso J.-P., Carroll S., Jha S., Horowits R., Fananapazir L.
    Cell Motil. Cytoskeleton 55:200-212(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT VAL-1183.
  2. "Human Nrap, a novel gene which interact with actin."
    Yuan H.F., Wang X., Wang D.M., Li H.M., Feng K., Bai C.X., Zhang R., Chen L., Li Y.H., Gao Y.H., Zhen M., Yue W., Xie C., Xie X.Y., Niu L.L., Gao W.J., Zhang J., Cao H., Pei X.T.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS ALA-208; THR-344; ARG-360 AND VAL-674.
    Tissue: Skeletal muscleImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-208; CYS-249; THR-344; ARG-360; LEU-490; CYS-884; VAL-1112; VAL-1183; PRO-1531 AND CYS-1566.
    Tissue: Skeletal muscle.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-490.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-580 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1311-1730 (ISOFORM 1), VARIANTS ALA-208; THR-344 AND ARG-360.
    Tissue: Skeletal muscleImported.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-270 (ISOFORM 1), VARIANT ALA-208.
    Tissue: Skeletal muscleImported.
  7. "Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes."
    Luo G., Leroy E., Kozak C.A., Polymeropoulos M.H., Horowits R.
    Genomics 45:229-232(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1004-1080 (ISOFORM 1).
  8. "Cloning and characterization of a novel human gene encoding a protein of 394 amino acids with significant motif of nebulin signature IV and nebulin repeat."
    Zhang D.L., Cai J.J., Ma D.L.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1314-1730 (ISOFORM 1).

Entry informationi

Entry nameiNRAP_HUMAN
AccessioniPrimary (citable) accession number: Q86VF7
Secondary accession number(s): O15500
, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3