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Protein

Nebulin-related-anchoring protein

Gene

NRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nebulin-related-anchoring protein
Short name:
N-RAP
Gene namesi
Name:NRAPImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:7988. NRAP.

Subcellular locationi


    Note: Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle.1 Publication

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4892.
OpenTargetsiENSG00000197893.
PharmGKBiPA31767.

Polymorphism and mutation databases

BioMutaiNRAP.
DMDMi115502505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002504251 – 1730Nebulin-related-anchoring proteinAdd BLAST1730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1081PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ86VF7.
PeptideAtlasiQ86VF7.
PRIDEiQ86VF7.

PTM databases

iPTMnetiQ86VF7.
PhosphoSitePlusiQ86VF7.
SwissPalmiQ86VF7.

Expressioni

Tissue specificityi

Expressed in cardiac and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000197893.
ExpressionAtlasiQ86VF7. baseline and differential.
GenevisibleiQ86VF7. HS.

Organism-specific databases

HPAiHPA037953.
HPA037954.

Interactioni

Subunit structurei

Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL. Interacts with CSRP3.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN2P356092EBI-5660292,EBI-77797
CSRP3P504612EBI-5660292,EBI-5658719

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110951. 4 interactors.
IntActiQ86VF7. 3 interactors.
MINTiMINT-4726323.
STRINGi9606.ENSP00000353078.

Structurei

3D structure databases

ProteinModelPortaliQ86VF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 64LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61
Repeati63 – 97Nebulin 1Sequence analysisAdd BLAST35
Repeati156 – 166Nebulin 2Sequence analysisAdd BLAST11
Repeati175 – 202Nebulin 3Sequence analysisAdd BLAST28
Repeati203 – 237Nebulin 4Sequence analysisAdd BLAST35
Repeati246 – 273Nebulin 5Sequence analysisAdd BLAST28
Repeati298 – 307Nebulin 6Sequence analysis10
Repeati316 – 343Nebulin 7Sequence analysisAdd BLAST28
Repeati348 – 382Nebulin 8Sequence analysisAdd BLAST35
Repeati389 – 417Nebulin 9Sequence analysisAdd BLAST29
Repeati419 – 453Nebulin 10Sequence analysisAdd BLAST35
Repeati487 – 521Nebulin 11Sequence analysisAdd BLAST35
Repeati522 – 556Nebulin 12Sequence analysisAdd BLAST35
Repeati558 – 592Nebulin 13Sequence analysisAdd BLAST35
Repeati602 – 626Nebulin 14Sequence analysisAdd BLAST25
Repeati627 – 661Nebulin 15Sequence analysisAdd BLAST35
Repeati662 – 692Nebulin 16Sequence analysisAdd BLAST31
Repeati702 – 724Nebulin 17Sequence analysisAdd BLAST23
Repeati726 – 760Nebulin 18Sequence analysisAdd BLAST35
Repeati761 – 795Nebulin 19Sequence analysisAdd BLAST35
Repeati797 – 831Nebulin 20Sequence analysisAdd BLAST35
Repeati844 – 869Nebulin 21Sequence analysisAdd BLAST26
Repeati870 – 896Nebulin 22Sequence analysisAdd BLAST27
Repeati901 – 935Nebulin 23Sequence analysisAdd BLAST35
Repeati945 – 963Nebulin 24Sequence analysisAdd BLAST19
Repeati969 – 1003Nebulin 25Sequence analysisAdd BLAST35
Repeati1004 – 1038Nebulin 26Sequence analysisAdd BLAST35
Repeati1040 – 1074Nebulin 27Sequence analysisAdd BLAST35
Repeati1078 – 1112Nebulin 28Sequence analysisAdd BLAST35
Repeati1113 – 1139Nebulin 29Sequence analysisAdd BLAST27
Repeati1144 – 1178Nebulin 30Sequence analysisAdd BLAST35
Repeati1183 – 1206Nebulin 31Sequence analysisAdd BLAST24
Repeati1212 – 1246Nebulin 32Sequence analysisAdd BLAST35
Repeati1247 – 1281Nebulin 33Sequence analysisAdd BLAST35
Repeati1283 – 1317Nebulin 34Sequence analysisAdd BLAST35
Repeati1321 – 1355Nebulin 35Sequence analysisAdd BLAST35
Repeati1356 – 1390Nebulin 36Sequence analysisAdd BLAST35
Repeati1391 – 1421Nebulin 37Sequence analysisAdd BLAST31
Repeati1429 – 1449Nebulin 38Sequence analysisAdd BLAST21
Repeati1455 – 1481Nebulin 39Sequence analysisAdd BLAST27
Repeati1490 – 1524Nebulin 40Sequence analysisAdd BLAST35
Repeati1526 – 1560Nebulin 41Sequence analysisAdd BLAST35
Repeati1564 – 1598Nebulin 42Sequence analysisAdd BLAST35
Repeati1599 – 1626Nebulin 43Sequence analysisAdd BLAST28
Repeati1640 – 1664Nebulin 44Sequence analysisAdd BLAST25

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
Contains 44 nebulin repeats.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1702. Eukaryota.
ENOG4111GQ8. LUCA.
GeneTreeiENSGT00530000062924.
HOVERGENiHBG052905.
InParanoidiQ86VF7.
PhylomeDBiQ86VF7.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR013998. Nebulin.
IPR000900. Nebulin_repeat.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 1 hit.
PF00880. Nebulin. 12 hits.
[Graphical view]
PRINTSiPR00510. NEBULIN.
SMARTiSM00132. LIM. 1 hit.
SM00227. NEBU. 41 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS51216. NEBULIN. 44 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q86VF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK
60 70 80 90 100
KPYCHAHNPK NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH
110 120 130 140 150
WDMKSKDKEG APNRQPLANE RAYWTGYGEG NAWCPGALPD PEIVRMVEAR
160 170 180 190 200
KSLGEEYTED YEQPRGKGSF PAMITPAYQR AKKANQLASQ VEYKRGHDER
210 220 230 240 250
ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS FPAMITPAYQ
260 270 280 290 300
IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE
310 320 330 340 350
EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL
360 370 380 390 400
PAQDNLVLKQ AQSVNKLVSE VEYKKDLESS RGHSINYCET PQFRNVSKIS
410 420 430 440 450
KFTSDNKYKE NYQNHMRGRY EGVGMDRRTL HAMKVGSLAS NVAYKADYKH
460 470 480 490 500
DIVDYNYPAT LTPSYQTAMK LVPLKDANYR QSIDKLKYSS VTDTPQIVQA
510 520 530 540 550
KINAQQLSHV NYRADYEKNK LNYTLPQDVP QLVKAKTNAK LFSEVKYKEG
560 570 580 590 600
WEKTKGKGFE MKLDAMSLLA AKASGELASN IKYKEEYEKT KGKAMGTADS
610 620 630 640 650
RLLHSLQIAK MSSEVEYKKG FEESKTRFHL PMDMVNIRHA KKAQTLASDL
660 670 680 690 700
DYRKKLHEYT VLPEDMKTQW AKKAYGLQSE LQYKADLAWM KGVGWLTEGS
710 720 730 740 750
LNLEQAKKAG QLVSEKNYRQ RVDELKFTSV TDSSQMEHAK KSQELQSGVA
760 770 780 790 800
YKAGNEQSVH QYTISKDEPL FLQARANAAN LSEKLYKSSW ENQKAKGFEL
810 820 830 840 850
RLDSLTFLAA KAKRDLASEV KYKEDYERSR GKLIGAKDVQ GDSQMSHSLQ
860 870 880 890 900
MSKLQSELEY KKGFEDTKSQ CHVSLDMVHL VHARKAQHLA TDVGYKTAEH
910 920 930 940 950
HFTALPTDMK VEWAKKAYGL QSDNQYRADV KWMKGMGWVA TGSLNVEQAK
960 970 980 990 1000
KAGELISEKK YRQHPDALKF TSIKDTPEMV QARISYTQAV DRLYREQGEN
1010 1020 1030 1040 1050
IKHHYTPTAD LPEVLLAKLN AMNISETRYK ESWSKLRDGG YKLRLDALPF
1060 1070 1080 1090 1100
QAAKASGEII SDYKYKEAFE KMKGQMLGSR SLEDDISLAH SVYATSLQSD
1110 1120 1130 1140 1150
VNYKKGFEHS KAQFHLPLDM AALVHAKKAQ TLASNQDYKH PLPQYTSLAE
1160 1170 1180 1190 1200
DLRLSCAKKA HKLQSENLYR SDLNFMRGVA CVIPGTLEIE GRKKASELIS
1210 1220 1230 1240 1250
ESKYRQHPHS FKYTAVTDTP NLLHAKFSNQ ITNERLYKAA GEDARHEYTM
1260 1270 1280 1290 1300
TLGLPEFIRA KTNAANLSDA RYKESWRNLR AQGYKLTIEA LPFQAARASG
1310 1320 1330 1340 1350
DIASDFLYRH DFVKERGKLI GPQSVRDDPR IQHCRRMGQL QSELQYRRGA
1360 1370 1380 1390 1400
TSSQAQFHLP MDMVHLVHAK NAQALASDHD YRTQYHKFTA LPEDLKMAWA
1410 1420 1430 1440 1450
KKAHALQSEL RYKSDLIGMK GIGWLALRSP QMESAKKAGE LISETKYRKK
1460 1470 1480 1490 1500
PDSIKFTTVV DSPDLVHAKN SYMHCNERMY RSGDAESLHR YTLIPDHPDF
1510 1520 1530 1540 1550
TRARLNALHL SDKVYRNSWE QTRAGSYDFR LDAIPFQTAR ASREIASDFR
1560 1570 1580 1590 1600
YKEAFLRDRG LQIGYRSVDD DPRMKHFLNV GRLQSDNEYK KDFAKSRSQF
1610 1620 1630 1640 1650
HSSTDQPGLL QAKRSQQLAS DVHYRQPLPQ PTCDPEQLGL RHAQKAHQLQ
1660 1670 1680 1690 1700
SDVKYKSDLN LTRGVGWTPP GSYKVEMARR AAELANARGL GLQGAYRGAE
1710 1720 1730
AVEAGDHQSG EVNPDATEIL HVKKKKALLL
Length:1,730
Mass (Da):197,074
Last modified:October 3, 2006 - v2
Checksum:i2F6AD0C7C07EC797
GO
Isoform 21 Publication (identifier: Q86VF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-580: N → NVHLLLSLK

Note: Gene prediction based on EST data.Curated
Show »
Length:1,738
Mass (Da):197,978
Checksum:iD6A39759359FB9BF
GO
Isoform 31 Publication (identifier: Q86VF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.
     580-580: N → NVHLLLSLK

Note: Gene prediction based on EST data.Curated
Show »
Length:1,703
Mass (Da):193,902
Checksum:iE7FA287C6611A0CD
GO
Isoform 42 Publications (identifier: Q86VF7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.

Show »
Length:1,695
Mass (Da):192,997
Checksum:iFA5D00F9978B811A
GO

Sequence cautioni

The sequence AAH58825 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH70130 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAQ09536 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04884 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224S → N in CAD38623 (PubMed:17974005).Curated1
Sequence conflicti261D → G in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti338F → S in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti395N → D in CAD38623 (PubMed:17974005).Curated1
Sequence conflicti488Y → H in CAE45811 (PubMed:17974005).Curated1
Sequence conflicti545V → A in BAB71328 (PubMed:14702039).Curated1
Sequence conflicti658E → G in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti862K → E in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti862K → E in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1210S → P in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1236L → F in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti1260A → V in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1348R → K in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1357F → L in CAD89899 (PubMed:17974005).Curated1
Sequence conflicti1414S → L in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1563I → V in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti1607P → H in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti1672S → P in CAD38623 (PubMed:17974005).Curated1
Sequence conflicti1696Y → YQ in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti1696Y → YQ in CAD89998 (PubMed:17974005).Curated1
Sequence conflicti1696Y → YQ (PubMed:15164054).Curated1
Sequence conflicti1697R → Q in CAD89899 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034073132A → S.Corresponds to variant rs34700024dbSNPEnsembl.1
Natural variantiVAR_034074186Q → E.Corresponds to variant rs35049661dbSNPEnsembl.1
Natural variantiVAR_027556208V → A.4 PublicationsCorresponds to variant rs2154028dbSNPEnsembl.1
Natural variantiVAR_027557249Y → C.1 PublicationCorresponds to variant rs2185913dbSNPEnsembl.1
Natural variantiVAR_034075282A → T.Corresponds to variant rs2275799dbSNPEnsembl.1
Natural variantiVAR_027558344A → T.3 PublicationsCorresponds to variant rs3121478dbSNPEnsembl.1
Natural variantiVAR_027559360Q → R.3 PublicationsCorresponds to variant rs3127106dbSNPEnsembl.1
Natural variantiVAR_050160484D → N.Corresponds to variant rs11196400dbSNPEnsembl.1
Natural variantiVAR_034076490S → L.2 PublicationsCorresponds to variant rs3189030dbSNPEnsembl.1
Natural variantiVAR_034077519N → I.Corresponds to variant rs2270182dbSNPEnsembl.1
Natural variantiVAR_050161647A → S.Corresponds to variant rs2286734dbSNPEnsembl.1
Natural variantiVAR_034078674A → V.1 PublicationCorresponds to variant rs2286735dbSNPEnsembl.1
Natural variantiVAR_034079884R → C.1 PublicationCorresponds to variant rs868738dbSNPEnsembl.1
Natural variantiVAR_0613571022M → V.Corresponds to variant rs34523503dbSNPEnsembl.1
Natural variantiVAR_0340801112A → V.1 PublicationCorresponds to variant rs1539587dbSNPEnsembl.1
Natural variantiVAR_0501621183I → V.2 PublicationsCorresponds to variant rs10749138dbSNPEnsembl.1
Natural variantiVAR_0275601531L → P.1 PublicationCorresponds to variant rs11196389dbSNPEnsembl.1
Natural variantiVAR_0501631566R → C.1 PublicationCorresponds to variant rs1885434dbSNPEnsembl.1
Natural variantiVAR_0501641569D → N.Corresponds to variant rs11575798dbSNPEnsembl.1
Natural variantiVAR_0501651643A → S.Corresponds to variant rs11575797dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052165371 – 405Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_052166580N → NVHLLLSLK in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177620 mRNA. Translation: AAO47073.1.
AY177621 mRNA. Translation: AAO47074.1.
AY081943 mRNA. Translation: AAL99185.2.
AL831980 mRNA. Translation: CAD89899.1.
AL832025 mRNA. Translation: CAD89910.1.
AL832330 mRNA. Translation: CAD38623.1.
AL832457 mRNA. Translation: CAD89998.1.
BX640682 mRNA. Translation: CAE45811.1.
BX640730 mRNA. Translation: CAE45846.1.
BX641052 mRNA. Translation: CAE46027.1.
AL390197 Genomic DNA. Translation: CAH71110.1.
AL390197 Genomic DNA. Translation: CAH71111.1.
AK056969 mRNA. Translation: BAB71328.1.
AK096886 mRNA. Translation: BAC04884.1. Different initiation.
BC058825 mRNA. Translation: AAH58825.1. Sequence problems.
BC070130 mRNA. Translation: AAH70130.1. Sequence problems.
U96486 Genomic DNA. Translation: AAC51786.1.
AF542553 mRNA. Translation: AAQ09536.1. Different initiation.
CCDSiCCDS7578.1. [Q86VF7-4]
CCDS7579.1. [Q86VF7-1]
RefSeqiNP_001248392.1. NM_001261463.1.
NP_006166.3. NM_006175.4. [Q86VF7-4]
NP_932326.2. NM_198060.3. [Q86VF7-1]
UniGeneiHs.268788.

Genome annotation databases

EnsembliENST00000359988; ENSP00000353078; ENSG00000197893. [Q86VF7-1]
ENST00000360478; ENSP00000353666; ENSG00000197893. [Q86VF7-4]
ENST00000369360; ENSP00000358367; ENSG00000197893. [Q86VF7-3]
GeneIDi4892.
KEGGihsa:4892.
UCSCiuc001laj.5. human. [Q86VF7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177620 mRNA. Translation: AAO47073.1.
AY177621 mRNA. Translation: AAO47074.1.
AY081943 mRNA. Translation: AAL99185.2.
AL831980 mRNA. Translation: CAD89899.1.
AL832025 mRNA. Translation: CAD89910.1.
AL832330 mRNA. Translation: CAD38623.1.
AL832457 mRNA. Translation: CAD89998.1.
BX640682 mRNA. Translation: CAE45811.1.
BX640730 mRNA. Translation: CAE45846.1.
BX641052 mRNA. Translation: CAE46027.1.
AL390197 Genomic DNA. Translation: CAH71110.1.
AL390197 Genomic DNA. Translation: CAH71111.1.
AK056969 mRNA. Translation: BAB71328.1.
AK096886 mRNA. Translation: BAC04884.1. Different initiation.
BC058825 mRNA. Translation: AAH58825.1. Sequence problems.
BC070130 mRNA. Translation: AAH70130.1. Sequence problems.
U96486 Genomic DNA. Translation: AAC51786.1.
AF542553 mRNA. Translation: AAQ09536.1. Different initiation.
CCDSiCCDS7578.1. [Q86VF7-4]
CCDS7579.1. [Q86VF7-1]
RefSeqiNP_001248392.1. NM_001261463.1.
NP_006166.3. NM_006175.4. [Q86VF7-4]
NP_932326.2. NM_198060.3. [Q86VF7-1]
UniGeneiHs.268788.

3D structure databases

ProteinModelPortaliQ86VF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110951. 4 interactors.
IntActiQ86VF7. 3 interactors.
MINTiMINT-4726323.
STRINGi9606.ENSP00000353078.

PTM databases

iPTMnetiQ86VF7.
PhosphoSitePlusiQ86VF7.
SwissPalmiQ86VF7.

Polymorphism and mutation databases

BioMutaiNRAP.
DMDMi115502505.

Proteomic databases

PaxDbiQ86VF7.
PeptideAtlasiQ86VF7.
PRIDEiQ86VF7.

Protocols and materials databases

DNASUi4892.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359988; ENSP00000353078; ENSG00000197893. [Q86VF7-1]
ENST00000360478; ENSP00000353666; ENSG00000197893. [Q86VF7-4]
ENST00000369360; ENSP00000358367; ENSG00000197893. [Q86VF7-3]
GeneIDi4892.
KEGGihsa:4892.
UCSCiuc001laj.5. human. [Q86VF7-1]

Organism-specific databases

CTDi4892.
DisGeNETi4892.
GeneCardsiNRAP.
H-InvDBHIX0009218.
HGNCiHGNC:7988. NRAP.
HPAiHPA037953.
HPA037954.
MIMi602873. gene.
neXtProtiNX_Q86VF7.
OpenTargetsiENSG00000197893.
PharmGKBiPA31767.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1702. Eukaryota.
ENOG4111GQ8. LUCA.
GeneTreeiENSGT00530000062924.
HOVERGENiHBG052905.
InParanoidiQ86VF7.
PhylomeDBiQ86VF7.
TreeFamiTF313758.

Miscellaneous databases

GeneWikiiNRAP.
GenomeRNAii4892.
PROiQ86VF7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197893.
ExpressionAtlasiQ86VF7. baseline and differential.
GenevisibleiQ86VF7. HS.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR013998. Nebulin.
IPR000900. Nebulin_repeat.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 1 hit.
PF00880. Nebulin. 12 hits.
[Graphical view]
PRINTSiPR00510. NEBULIN.
SMARTiSM00132. LIM. 1 hit.
SM00227. NEBU. 41 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS51216. NEBULIN. 44 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRAP_HUMAN
AccessioniPrimary (citable) accession number: Q86VF7
Secondary accession number(s): O15500
, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.