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Q86VF7 (NRAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nebulin-related-anchoring protein

Short name=N-RAP
Gene names
Name:NRAP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1730 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix By similarity. UniProtKB Q80XB4

Subunit structure

Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL By similarity.

Subcellular location

Note: Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. Ref.1

Tissue specificity

Expressed in cardiac and skeletal muscle. Ref.1

Sequence similarities

Contains 1 LIM zinc-binding domain.

Contains 44 nebulin repeats.

Sequence caution

The sequence AAH58825.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH70130.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAQ09536.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC04884.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 Ref.3 (identifier: Q86VF7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.4 (identifier: Q86VF7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     580-580: N → NVHLLLSLK
Note: Gene prediction based on EST data.
Isoform 3 Ref.4 (identifier: Q86VF7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.
     580-580: N → NVHLLLSLK
Note: Gene prediction based on EST data.
Isoform 4 Ref.1 Ref.2 (identifier: Q86VF7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17301730Nebulin-related-anchoring protein
PRO_0000250425

Regions

Domain4 – 6461LIM zinc-binding
Repeat63 – 9735Nebulin 1
Repeat156 – 16611Nebulin 2
Repeat175 – 20228Nebulin 3
Repeat203 – 23735Nebulin 4
Repeat246 – 27328Nebulin 5
Repeat298 – 30710Nebulin 6
Repeat316 – 34328Nebulin 7
Repeat348 – 38235Nebulin 8
Repeat389 – 41729Nebulin 9
Repeat419 – 45335Nebulin 10
Repeat487 – 52135Nebulin 11
Repeat522 – 55635Nebulin 12
Repeat558 – 59235Nebulin 13
Repeat602 – 62625Nebulin 14
Repeat627 – 66135Nebulin 15
Repeat662 – 69231Nebulin 16
Repeat702 – 72423Nebulin 17
Repeat726 – 76035Nebulin 18
Repeat761 – 79535Nebulin 19
Repeat797 – 83135Nebulin 20
Repeat844 – 86926Nebulin 21
Repeat870 – 89627Nebulin 22
Repeat901 – 93535Nebulin 23
Repeat945 – 96319Nebulin 24
Repeat969 – 100335Nebulin 25
Repeat1004 – 103835Nebulin 26
Repeat1040 – 107435Nebulin 27
Repeat1078 – 111235Nebulin 28
Repeat1113 – 113927Nebulin 29
Repeat1144 – 117835Nebulin 30
Repeat1183 – 120624Nebulin 31
Repeat1212 – 124635Nebulin 32
Repeat1247 – 128135Nebulin 33
Repeat1283 – 131735Nebulin 34
Repeat1321 – 135535Nebulin 35
Repeat1356 – 139035Nebulin 36
Repeat1391 – 142131Nebulin 37
Repeat1429 – 144921Nebulin 38
Repeat1455 – 148127Nebulin 39
Repeat1490 – 152435Nebulin 40
Repeat1526 – 156035Nebulin 41
Repeat1564 – 159835Nebulin 42
Repeat1599 – 162628Nebulin 43
Repeat1640 – 166425Nebulin 44

Natural variations

Alternative sequence371 – 40535Missing in isoform 3 and isoform 4. Ref.1 Ref.2 Ref.4
VSP_052165
Alternative sequence5801N → NVHLLLSLK in isoform 2 and isoform 3. Ref.4
VSP_052166
Natural variant1321A → S.
Corresponds to variant rs34700024 [ dbSNP | Ensembl ].
VAR_034073
Natural variant1861Q → E.
Corresponds to variant rs35049661 [ dbSNP | Ensembl ].
VAR_034074
Natural variant2081V → A. Ref.2 Ref.3 Ref.3 Ref.5 Ref.6
Corresponds to variant rs2154028 [ dbSNP | Ensembl ].
VAR_027556
Natural variant2491Y → C. Ref.3 Ref.3
Corresponds to variant rs2185913 [ dbSNP | Ensembl ].
VAR_027557
Natural variant2821A → T.
Corresponds to variant rs2275799 [ dbSNP | Ensembl ].
VAR_034075
Natural variant3441A → T. Ref.2 Ref.3 Ref.3 Ref.5
Corresponds to variant rs3121478 [ dbSNP | Ensembl ].
VAR_027558
Natural variant3601Q → R. Ref.2 Ref.3 Ref.3 Ref.5
Corresponds to variant rs3127106 [ dbSNP | Ensembl ].
VAR_027559
Natural variant4841D → N.
Corresponds to variant rs11196400 [ dbSNP | Ensembl ].
VAR_050160
Natural variant4901S → L. Ref.3 Ref.4
Corresponds to variant rs3189030 [ dbSNP | Ensembl ].
VAR_034076
Natural variant5191N → I.
Corresponds to variant rs2270182 [ dbSNP | Ensembl ].
VAR_034077
Natural variant6471A → S.
Corresponds to variant rs2286734 [ dbSNP | Ensembl ].
VAR_050161
Natural variant6741A → V. Ref.2
Corresponds to variant rs2286735 [ dbSNP | Ensembl ].
VAR_034078
Natural variant8841R → C. Ref.3
Corresponds to variant rs868738 [ dbSNP | Ensembl ].
VAR_034079
Natural variant10221M → V.
Corresponds to variant rs34523503 [ dbSNP | Ensembl ].
VAR_061357
Natural variant11121A → V. Ref.3
Corresponds to variant rs1539587 [ dbSNP | Ensembl ].
VAR_034080
Natural variant11831I → V. Ref.1 Ref.3
Corresponds to variant rs10749138 [ dbSNP | Ensembl ].
VAR_050162
Natural variant15311L → P. Ref.3 Ref.3
Corresponds to variant rs11196389 [ dbSNP | Ensembl ].
VAR_027560
Natural variant15661R → C. Ref.3
Corresponds to variant rs1885434 [ dbSNP | Ensembl ].
VAR_050163
Natural variant15691D → N.
Corresponds to variant rs11575798 [ dbSNP | Ensembl ].
VAR_050164
Natural variant16431A → S.
Corresponds to variant rs11575797 [ dbSNP | Ensembl ].
VAR_050165

Experimental info

Sequence conflict2241S → N in CAD38623. Ref.3
Sequence conflict2611D → G in CAD89910. Ref.3
Sequence conflict3381F → S in CAE45846. Ref.3
Sequence conflict3951N → D in CAD38623. Ref.3
Sequence conflict4881Y → H in CAE45811. Ref.3
Sequence conflict5451V → A in BAB71328. Ref.5
Sequence conflict6581E → G in CAD89910. Ref.3
Sequence conflict8621K → E in CAD89910. Ref.3
Sequence conflict8621K → E in CAE45846. Ref.3
Sequence conflict12101S → P in CAE45846. Ref.3
Sequence conflict12361L → F in CAD89910. Ref.3
Sequence conflict12601A → V in CAE45846. Ref.3
Sequence conflict13481R → K in CAE45846. Ref.3
Sequence conflict13571F → L in CAD89899. Ref.3
Sequence conflict14141S → L in CAE45846. Ref.3
Sequence conflict15631I → V in CAD89910. Ref.3
Sequence conflict16071P → H in CAD89910. Ref.3
Sequence conflict16721S → P in CAD38623. Ref.3
Sequence conflict16961Y → YQ in CAD89910. Ref.3
Sequence conflict16961Y → YQ in CAD89998. Ref.3
Sequence conflict16961Y → YQ Ref.4
Sequence conflict16971R → Q in CAD89899. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: 2F6AD0C7C07EC797

FASTA1,730197,074
        10         20         30         40         50         60 
MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK KPYCHAHNPK 

        70         80         90        100        110        120 
NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH WDMKSKDKEG APNRQPLANE 

       130        140        150        160        170        180 
RAYWTGYGEG NAWCPGALPD PEIVRMVEAR KSLGEEYTED YEQPRGKGSF PAMITPAYQR 

       190        200        210        220        230        240 
AKKANQLASQ VEYKRGHDER ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS 

       250        260        270        280        290        300 
FPAMITPAYQ IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE 

       310        320        330        340        350        360 
EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL PAQDNLVLKQ 

       370        380        390        400        410        420 
AQSVNKLVSE VEYKKDLESS RGHSINYCET PQFRNVSKIS KFTSDNKYKE NYQNHMRGRY 

       430        440        450        460        470        480 
EGVGMDRRTL HAMKVGSLAS NVAYKADYKH DIVDYNYPAT LTPSYQTAMK LVPLKDANYR 

       490        500        510        520        530        540 
QSIDKLKYSS VTDTPQIVQA KINAQQLSHV NYRADYEKNK LNYTLPQDVP QLVKAKTNAK 

       550        560        570        580        590        600 
LFSEVKYKEG WEKTKGKGFE MKLDAMSLLA AKASGELASN IKYKEEYEKT KGKAMGTADS 

       610        620        630        640        650        660 
RLLHSLQIAK MSSEVEYKKG FEESKTRFHL PMDMVNIRHA KKAQTLASDL DYRKKLHEYT 

       670        680        690        700        710        720 
VLPEDMKTQW AKKAYGLQSE LQYKADLAWM KGVGWLTEGS LNLEQAKKAG QLVSEKNYRQ 

       730        740        750        760        770        780 
RVDELKFTSV TDSSQMEHAK KSQELQSGVA YKAGNEQSVH QYTISKDEPL FLQARANAAN 

       790        800        810        820        830        840 
LSEKLYKSSW ENQKAKGFEL RLDSLTFLAA KAKRDLASEV KYKEDYERSR GKLIGAKDVQ 

       850        860        870        880        890        900 
GDSQMSHSLQ MSKLQSELEY KKGFEDTKSQ CHVSLDMVHL VHARKAQHLA TDVGYKTAEH 

       910        920        930        940        950        960 
HFTALPTDMK VEWAKKAYGL QSDNQYRADV KWMKGMGWVA TGSLNVEQAK KAGELISEKK 

       970        980        990       1000       1010       1020 
YRQHPDALKF TSIKDTPEMV QARISYTQAV DRLYREQGEN IKHHYTPTAD LPEVLLAKLN 

      1030       1040       1050       1060       1070       1080 
AMNISETRYK ESWSKLRDGG YKLRLDALPF QAAKASGEII SDYKYKEAFE KMKGQMLGSR 

      1090       1100       1110       1120       1130       1140 
SLEDDISLAH SVYATSLQSD VNYKKGFEHS KAQFHLPLDM AALVHAKKAQ TLASNQDYKH 

      1150       1160       1170       1180       1190       1200 
PLPQYTSLAE DLRLSCAKKA HKLQSENLYR SDLNFMRGVA CVIPGTLEIE GRKKASELIS 

      1210       1220       1230       1240       1250       1260 
ESKYRQHPHS FKYTAVTDTP NLLHAKFSNQ ITNERLYKAA GEDARHEYTM TLGLPEFIRA 

      1270       1280       1290       1300       1310       1320 
KTNAANLSDA RYKESWRNLR AQGYKLTIEA LPFQAARASG DIASDFLYRH DFVKERGKLI 

      1330       1340       1350       1360       1370       1380 
GPQSVRDDPR IQHCRRMGQL QSELQYRRGA TSSQAQFHLP MDMVHLVHAK NAQALASDHD 

      1390       1400       1410       1420       1430       1440 
YRTQYHKFTA LPEDLKMAWA KKAHALQSEL RYKSDLIGMK GIGWLALRSP QMESAKKAGE 

      1450       1460       1470       1480       1490       1500 
LISETKYRKK PDSIKFTTVV DSPDLVHAKN SYMHCNERMY RSGDAESLHR YTLIPDHPDF 

      1510       1520       1530       1540       1550       1560 
TRARLNALHL SDKVYRNSWE QTRAGSYDFR LDAIPFQTAR ASREIASDFR YKEAFLRDRG 

      1570       1580       1590       1600       1610       1620 
LQIGYRSVDD DPRMKHFLNV GRLQSDNEYK KDFAKSRSQF HSSTDQPGLL QAKRSQQLAS 

      1630       1640       1650       1660       1670       1680 
DVHYRQPLPQ PTCDPEQLGL RHAQKAHQLQ SDVKYKSDLN LTRGVGWTPP GSYKVEMARR 

      1690       1700       1710       1720       1730 
AAELANARGL GLQGAYRGAE AVEAGDHQSG EVNPDATEIL HVKKKKALLL 

« Hide

Isoform 2 [UniParc].

Checksum: D6A39759359FB9BF
Show »

FASTA1,738197,978
Isoform 3 [UniParc].

Checksum: E7FA287C6611A0CD
Show »

FASTA1,703193,902
Isoform 4 [UniParc].

Checksum: FA5D00F9978B811A
Show »

FASTA1,695192,997

References

« Hide 'large scale' references
[1]"Genomic organization, alternative splicing, and expression of human and mouse N-RAP, a nebulin-related LIM protein of striated muscle."
Mohiddin S.A., Lu S., Cardoso J.-P., Carroll S., Jha S., Horowits R., Fananapazir L.
Cell Motil. Cytoskeleton 55:200-212(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT VAL-1183.
[2]"Human Nrap, a novel gene which interact with actin."
Yuan H.F., Wang X., Wang D.M., Li H.M., Feng K., Bai C.X., Zhang R., Chen L., Li Y.H., Gao Y.H., Zhen M., Yue W., Xie C., Xie X.Y., Niu L.L., Gao W.J., Zhang J., Cao H., Pei X.T.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS ALA-208; THR-344; ARG-360 AND VAL-674.
Tissue: Skeletal muscle.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-208; CYS-249; THR-344; ARG-360; LEU-490; CYS-884; VAL-1112; VAL-1183; PRO-1531 AND CYS-1566.
Tissue: Skeletal muscle.
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-490.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-580 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1311-1730 (ISOFORM 1), VARIANTS ALA-208; THR-344 AND ARG-360.
Tissue: Skeletal muscle.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-270 (ISOFORM 1), VARIANT ALA-208.
Tissue: Skeletal muscle.
[7]"Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes."
Luo G., Leroy E., Kozak C.A., Polymeropoulos M.H., Horowits R.
Genomics 45:229-232(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1004-1080 (ISOFORM 1).
[8]"Cloning and characterization of a novel human gene encoding a protein of 394 amino acids with significant motif of nebulin signature IV and nebulin repeat."
Zhang D.L., Cai J.J., Ma D.L.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1314-1730 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY177620 mRNA. Translation: AAO47073.1.
AY177621 mRNA. Translation: AAO47074.1.
AY081943 mRNA. Translation: AAL99185.2.
AL831980 mRNA. Translation: CAD89899.1.
AL832025 mRNA. Translation: CAD89910.1.
AL832330 mRNA. Translation: CAD38623.1.
AL832457 mRNA. Translation: CAD89998.1.
BX640682 mRNA. Translation: CAE45811.1.
BX640730 mRNA. Translation: CAE45846.1.
BX641052 mRNA. Translation: CAE46027.1.
AL390197 Genomic DNA. Translation: CAH71110.1.
AL390197 Genomic DNA. Translation: CAH71111.1.
AK056969 mRNA. Translation: BAB71328.1.
AK096886 mRNA. Translation: BAC04884.1. Different initiation.
BC058825 mRNA. Translation: AAH58825.1. Sequence problems.
BC070130 mRNA. Translation: AAH70130.1. Sequence problems.
U96486 Genomic DNA. Translation: AAC51786.1.
AF542553 mRNA. Translation: AAQ09536.1. Different initiation.
CCDSCCDS7578.1. [Q86VF7-4]
CCDS7579.1. [Q86VF7-1]
RefSeqNP_001248392.1. NM_001261463.1.
NP_006166.3. NM_006175.4. [Q86VF7-4]
NP_932326.2. NM_198060.3. [Q86VF7-1]
UniGeneHs.268788.

3D structure databases

ProteinModelPortalQ86VF7.
SMRQ86VF7. Positions 6-55.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110951. 4 interactions.
IntActQ86VF7. 1 interaction.
MINTMINT-4726323.

PTM databases

PhosphoSiteQ86VF7.

Polymorphism databases

DMDM115502505.

Proteomic databases

PaxDbQ86VF7.
PRIDEQ86VF7.

Protocols and materials databases

DNASU4892.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359988; ENSP00000353078; ENSG00000197893. [Q86VF7-1]
ENST00000360478; ENSP00000353666; ENSG00000197893. [Q86VF7-4]
ENST00000369358; ENSP00000358365; ENSG00000197893. [Q86VF7-2]
ENST00000369360; ENSP00000358367; ENSG00000197893. [Q86VF7-3]
GeneID4892.
KEGGhsa:4892.
UCSCuc001laj.4. human. [Q86VF7-1]
uc001lak.4. human. [Q86VF7-4]

Organism-specific databases

CTD4892.
GeneCardsGC10M115338.
H-InvDBHIX0009218.
HGNCHGNC:7988. NRAP.
HPAHPA037953.
HPA037954.
MIM602873. gene.
neXtProtNX_Q86VF7.
PharmGKBPA31767.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG262357.
HOVERGENHBG052905.
OMAFHLPMDM.
OrthoDBEOG7GFB81.
PhylomeDBQ86VF7.
TreeFamTF313758.

Gene expression databases

BgeeQ86VF7.
GenevestigatorQ86VF7.

Family and domain databases

Gene3D2.10.110.10. 1 hit.
InterProIPR013998. Nebulin.
IPR000900. Nebulin_repeat.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 1 hit.
PF00880. Nebulin. 19 hits.
[Graphical view]
PRINTSPR00510. NEBULIN.
SMARTSM00132. LIM. 1 hit.
SM00227. NEBU. 41 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS51216. NEBULIN. 44 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNRAP.
GenomeRNAi4892.
NextBio18829.
PROQ86VF7.
SOURCESearch...

Entry information

Entry nameNRAP_HUMAN
AccessionPrimary (citable) accession number: Q86VF7
Secondary accession number(s): O15500 expand/collapse secondary AC list , Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM