Q86VE9 (SERC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine incorporator 5

Gene names

Name:	SERINC5
Synonyms:	C5orf12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes By similarity. Ref.1
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain. Ref.1
Sequence similarities	Belongs to the TDE1 family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	myelination Inferred from electronic annotation. Source: Compara phosphatidylserine metabolic process Inferred from sequence or structural similarity. Source: HGNC phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of transferase activity Inferred from sequence or structural similarity. Source: HGNC
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW myelin sheath Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VE9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VE9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     413-416: NHVR → K

Isoform 3 (identifier: Q86VE9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     413-423: NHVRSAFHLLP → KNYQC

Isoform 4 (identifier: Q86VE9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     414-423: HVRSAFHLLP → YESANIESFFSGSWSIFWVKMASCWICVLLYLCTLVAPLCCPTREFSV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	Serine incorporator 5		PRO_0000330630
Regions
	Topological domain	1 – 36	36	Extracellular Potential
	Transmembrane	37 – 57	21	Helical; Potential
	Topological domain	58 – 89	32	Cytoplasmic Potential
	Transmembrane	90 – 110	21	Helical; Potential
	Topological domain	111 – 124	14	Extracellular Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Topological domain	146 – 156	11	Cytoplasmic Potential
	Transmembrane	157 – 177	21	Helical; Potential
	Topological domain	178 – 198	21	Extracellular Potential
	Transmembrane	199 – 219	21	Helical; Potential
	Topological domain	220 – 230	11	Cytoplasmic Potential
	Transmembrane	231 – 251	21	Helical; Potential
	Topological domain	252 – 258	7	Extracellular Potential
	Transmembrane	259 – 279	21	Helical; Potential
	Topological domain	280 – 311	32	Cytoplasmic Potential
	Transmembrane	312 – 332	21	Helical; Potential
	Topological domain	333 – 385	53	Extracellular Potential
	Transmembrane	386 – 406	21	Helical; Potential
	Topological domain	407 – 423	17	Cytoplasmic Potential
	Compositional bias	5 – 26	22	Cys-rich
Amino acid modifications
	Glycosylation	113	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	413 – 423	11	NHVRSAFHLLP → KNYQC in isoform 3.		VSP_033054
	Alternative sequence	413 – 416	4	NHVR → K in isoform 2.		VSP_033055
	Alternative sequence	414 – 423	10	HVRSAFHLLP → YESANIESFFSGSWSIFWVK MASCWICVLLYLCTLVAPLC CPTREFSV in isoform 4.		VSP_042310

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B05A461D418D049B	FASTA	423	47,009
	10 20 30 40 50 60 MSAQCCAGQL ACCCGSAGCS LCCDCCPRIR QSLSTRFMYA LYFILVVVLC CIMMSTTVAH 70 80 90 100 110 120 KMKEHIPFFE DMCKGIKAGD TCEKLVGYSA VYRVCFGMAC FFFIFCLLTL KINNSKSCRA 130 140 150 160 170 180 HIHNGFWFFK LLLLGAMCSG AFFIPDQDTF LNAWRYVGAV GGFLFIGIQL LLLVEFAHKW 190 200 210 220 230 240 NKNWTAGTAS NKLWYASLAL VTLIMYSIAT GGLVLMAVFY TQKDSCMENK ILLGVNGGLC 250 260 270 280 290 300 LLISLVAISP WVQNRQPHSG LLQSGVISCY VTYLTFSALS SKPAEVVLDE HGKNVTICVP 310 320 330 340 350 360 DFGQDLYRDE NLVTILGTSL LIGCILYSCL TSTTRSSSDA LQGRYAAPEL EIARCCFCFS 370 380 390 400 410 420 PGGEDTEEQQ PGKEGPRVIY DEKKGTVYIY SYFHFVFFLA SLYVMMTVTN WFNHVRSAFH LLP
	Isoform 2 [UniParc]. Checksum: 8ACF67E0D648341F	FASTA	420	46,631
	10 20 30 40 50 60 MSAQCCAGQL ACCCGSAGCS LCCDCCPRIR QSLSTRFMYA LYFILVVVLC CIMMSTTVAH 70 80 90 100 110 120 KMKEHIPFFE DMCKGIKAGD TCEKLVGYSA VYRVCFGMAC FFFIFCLLTL KINNSKSCRA 130 140 150 160 170 180 HIHNGFWFFK LLLLGAMCSG AFFIPDQDTF LNAWRYVGAV GGFLFIGIQL LLLVEFAHKW 190 200 210 220 230 240 NKNWTAGTAS NKLWYASLAL VTLIMYSIAT GGLVLMAVFY TQKDSCMENK ILLGVNGGLC 250 260 270 280 290 300 LLISLVAISP WVQNRQPHSG LLQSGVISCY VTYLTFSALS SKPAEVVLDE HGKNVTICVP 310 320 330 340 350 360 DFGQDLYRDE NLVTILGTSL LIGCILYSCL TSTTRSSSDA LQGRYAAPEL EIARCCFCFS 370 380 390 400 410 420 PGGEDTEEQQ PGKEGPRVIY DEKKGTVYIY SYFHFVFFLA SLYVMMTVTN WFKSAFHLLP
	Isoform 3 [UniParc]. Checksum: BF994EA5EFBEEDC7	FASTA	417	46,373
	10 20 30 40 50 60 MSAQCCAGQL ACCCGSAGCS LCCDCCPRIR QSLSTRFMYA LYFILVVVLC CIMMSTTVAH 70 80 90 100 110 120 KMKEHIPFFE DMCKGIKAGD TCEKLVGYSA VYRVCFGMAC FFFIFCLLTL KINNSKSCRA 130 140 150 160 170 180 HIHNGFWFFK LLLLGAMCSG AFFIPDQDTF LNAWRYVGAV GGFLFIGIQL LLLVEFAHKW 190 200 210 220 230 240 NKNWTAGTAS NKLWYASLAL VTLIMYSIAT GGLVLMAVFY TQKDSCMENK ILLGVNGGLC 250 260 270 280 290 300 LLISLVAISP WVQNRQPHSG LLQSGVISCY VTYLTFSALS SKPAEVVLDE HGKNVTICVP 310 320 330 340 350 360 DFGQDLYRDE NLVTILGTSL LIGCILYSCL TSTTRSSSDA LQGRYAAPEL EIARCCFCFS 370 380 390 400 410 PGGEDTEEQQ PGKEGPRVIY DEKKGTVYIY SYFHFVFFLA SLYVMMTVTN WFKNYQC
	Isoform 4 [UniParc]. Checksum: 3B74F5AA1944E437	FASTA	461	51,335
	10 20 30 40 50 60 MSAQCCAGQL ACCCGSAGCS LCCDCCPRIR QSLSTRFMYA LYFILVVVLC CIMMSTTVAH 70 80 90 100 110 120 KMKEHIPFFE DMCKGIKAGD TCEKLVGYSA VYRVCFGMAC FFFIFCLLTL KINNSKSCRA 130 140 150 160 170 180 HIHNGFWFFK LLLLGAMCSG AFFIPDQDTF LNAWRYVGAV GGFLFIGIQL LLLVEFAHKW 190 200 210 220 230 240 NKNWTAGTAS NKLWYASLAL VTLIMYSIAT GGLVLMAVFY TQKDSCMENK ILLGVNGGLC 250 260 270 280 290 300 LLISLVAISP WVQNRQPHSG LLQSGVISCY VTYLTFSALS SKPAEVVLDE HGKNVTICVP 310 320 330 340 350 360 DFGQDLYRDE NLVTILGTSL LIGCILYSCL TSTTRSSSDA LQGRYAAPEL EIARCCFCFS 370 380 390 400 410 420 PGGEDTEEQQ PGKEGPRVIY DEKKGTVYIY SYFHFVFFLA SLYVMMTVTN WFNYESANIE 430 440 450 460 SFFSGSWSIF WVKMASCWIC VLLYLCTLVA PLCCPTREFS V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a novel human C5orf12 gene, a member of the TMS_TDE family." Xu J., Ji C., Wang L., Cao Y., Dai J., Ye X., Zeng L., Dai J., Wu Q., Xie Y., Mao Y. Mol. Biol. Rep. 30:47-52(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Fetus.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF498273 mRNA. Translation: AAP06800.1. AK297467 mRNA. Translation: BAG59889.1. AC010260 Genomic DNA. No translation available. AC012636 Genomic DNA. No translation available. CH471084 Genomic DNA. Translation: EAW95843.1. CH471084 Genomic DNA. Translation: EAW95844.1. CH471084 Genomic DNA. Translation: EAW95845.1. BC101280 mRNA. Translation: AAI01281.1. BC101281 mRNA. Translation: AAI01282.1. BC101283 mRNA. Translation: AAI01284.1.
IPI	IPI00890708. IPI00966609. IPI00966938.
RefSeq	NP_001167542.1. NM_001174071.1. NP_001167543.1. NM_001174072.1. NP_840060.1. NM_178276.5.
UniGene	Hs.288232.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47313N.
STRING	9606.ENSP00000406585.
PTM databases
PhosphoSite	Q86VE9.
Polymorphism databases
DMDM	74714045.
Proteomic databases
PaxDb	Q86VE9.
PRIDE	Q86VE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000507668; ENSP00000426237; ENSG00000164300. ENST00000512721; ENSP00000420863; ENSG00000164300. ENST00000512972; ENSP00000421665; ENSG00000164300.
GeneID	256987.
KEGG	hsa:256987.
UCSC	uc003kgj.3. human. uc003kgm.3. human.
Organism-specific databases
CTD	256987.
GeneCards	GC05M079407.
HGNC	HGNC:18825. SERINC5.
HPA	HPA037898.
MIM	614551. gene.
neXtProt	NX_Q86VE9.
PharmGKB	PA38698.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG247442.
HOGENOM	HOG000165463.
HOVERGEN	HBG025699.
InParanoid	Q86VE9.
OMA	SIFWVKM.
OrthoDB	EOG4D26PW.
Gene expression databases
ArrayExpress	Q86VE9.
Bgee	Q86VE9.
CleanEx	HS_SERINC5.
Genevestigator	Q86VE9.
Family and domain databases
InterPro	IPR005016. TMS_TDE. IPR015460. TPO1. [Graphical view]
PANTHER	PTHR10383. PTHR10383. 1 hit. PTHR10383:SF4. PTHR10383:SF4. 1 hit.
Pfam	PF03348. Serinc. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SERINC5. human.
GenomeRNAi	256987.
NextBio	92895.
SOURCE	Search...

Entry information

Entry name

SERC5_HUMAN

Accession

Primary (citable) accession number: Q86VE9
Secondary accession number(s): B4DMH7, Q495A4, Q495A6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.