Q86VE3 (SATL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spermidine/spermine N(1)-acetyltransferase-like protein 1
EC=2.3.1.-

Gene names

Name:

SATL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the acetyltransferase family. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	N-acetyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VE3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VE3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     439-445: GLGIGAE → DSHHNSM
     446-508: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Spermidine/spermine N(1)-acetyltransferase-like protein 1		PRO_0000282928
Regions
	Domain	342 – 508	167	N-acetyltransferase
	Region	365 – 366	2	Substrate binding By similarity
	Region	431 – 433	3	Acetyl-CoA binding By similarity
	Region	439 – 444	6	Acetyl-CoA binding By similarity
	Region	463 – 465	3	Substrate binding By similarity
	Compositional bias	8 – 336	329	Gln-rich
Sites
	Binding site	489	1	Substrate By similarity
Natural variations
	Alternative sequence	439 – 445	7	GLGIGAE → DSHHNSM in isoform 2.		VSP_024253
	Alternative sequence	446 – 508	63	Missing in isoform 2.		VSP_024254
	Natural variant	92	1	W → R. Ref.2 Corresponds to variant rs10126146 [ dbSNP | Ensembl ].		VAR_031438
Experimental info
	Sequence conflict	239	1	P → L in AAI26402. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 3. Checksum: FB45D4AEB625A024	FASTA	508	55,833
	10 20 30 40 50 60 MSPPGMWQPG VQQPGISQQV PSHPDMSQPG MSQQVPSQPG IRQPDTSQSC KNQTDMSQPD 70 80 90 100 110 120 ANQSSLSDSN QTGIIQPSPS LLGMNQMDMN QWSASLYEMN QVDMKQPSMS QAGMRQSGTN 130 140 150 160 170 180 LPDINQPGMK QPGTWQLGRS QPGMWPQSLS ELVLSEASIS QPGPPQRAPS QSGPRQSSTS 190 200 210 220 230 240 QAGTNQSGIS QPVMWQLDMR QSGGSQPSMR QVGTSQSGTS QIGMSQPGTW QTGLSQPVPR 250 260 270 280 290 300 QPNKSPPGMW QRGMWQPGMS QQVPSQLGMR QPGTSQSSKN QTGMSHPGRG QPGIWEPGPS 310 320 330 340 350 360 QPGLSQQDLN QLVLSQPGLS QPGRSQPSVS QMGMRQTSMD YFQIRHAEAG DCPEILRLIK 370 380 390 400 410 420 ELAACENMLD AMELTAADLL RDGFGDNPLF YCLIAEVNDQ QKPSGKLTVG FAMYYFTYDS 430 440 450 460 470 480 WTGKVLYLED FYVTQAYQGL GIGAEMLKRL SQIAITTQCN CMHFLVVIWN QASINYYTSR 490 500 GALDLSSEEG WHLFRFNREE LLDMAWEE
	Isoform 2 [UniParc]. Checksum: 22CEB636BB70165E	FASTA	445	48,551
	10 20 30 40 50 60 MSPPGMWQPG VQQPGISQQV PSHPDMSQPG MSQQVPSQPG IRQPDTSQSC KNQTDMSQPD 70 80 90 100 110 120 ANQSSLSDSN QTGIIQPSPS LLGMNQMDMN QWSASLYEMN QVDMKQPSMS QAGMRQSGTN 130 140 150 160 170 180 LPDINQPGMK QPGTWQLGRS QPGMWPQSLS ELVLSEASIS QPGPPQRAPS QSGPRQSSTS 190 200 210 220 230 240 QAGTNQSGIS QPVMWQLDMR QSGGSQPSMR QVGTSQSGTS QIGMSQPGTW QTGLSQPVPR 250 260 270 280 290 300 QPNKSPPGMW QRGMWQPGMS QQVPSQLGMR QPGTSQSSKN QTGMSHPGRG QPGIWEPGPS 310 320 330 340 350 360 QPGLSQQDLN QLVLSQPGLS QPGRSQPSVS QMGMRQTSMD YFQIRHAEAG DCPEILRLIK 370 380 390 400 410 420 ELAACENMLD AMELTAADLL RDGFGDNPLF YCLIAEVNDQ QKPSGKLTVG FAMYYFTYDS 430 440 WTGKVLYLED FYVTQAYQDS HHNSM

References

[1]

"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-92. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z99571 Genomic DNA. Translation: CAI42723.1. BC043215 mRNA. Translation: AAH43215.2. BC126401 mRNA. Translation: AAI26402.1.
IPI	IPI00328878. IPI00844497.
RefSeq	NP_001012998.2. NM_001012980.2.
UniGene	Hs.640783.
3D structure databases
HSSP	HSSP built from PDB template 2B5G based on UniProtKB P21673.
ProteinModelPortal	Q86VE3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000329115.
PTM databases
PhosphoSite	Q86VE3.
Polymorphism databases
DMDM	143583359.
Proteomic databases
PaxDb	Q86VE3.
PRIDE	Q86VE3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332921; ENSP00000329115; ENSG00000184788. ENST00000395409; ENSP00000378804; ENSG00000184788.
GeneID	340562.
KEGG	hsa:340562.
Organism-specific databases
CTD	340562.
GeneCards	GC0XM084347.
HGNC	HGNC:27992. SATL1.
neXtProt	NX_Q86VE3.
PharmGKB	PA134969637.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG289508.
HOGENOM	HOG000154259.
HOVERGEN	HBG108460.
InParanoid	Q86VE3.
Gene expression databases
ArrayExpress	Q86VE3.
Bgee	Q86VE3.
CleanEx	HS_SATL1.
Genevestigator	Q86VE3.
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000182. GNAT_dom. [Graphical view]
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	340562.
NextBio	97935.

Entry information

Entry name

SATL1_HUMAN

Accession

Primary (citable) accession number: Q86VE3
Secondary accession number(s): A0AVK7, Q5H8V9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.