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Protein

Spermidine/spermine N(1)-acetyltransferase-like protein 1

Gene

SATL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei489SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine/spermine N(1)-acetyltransferase-like protein 1 (EC:2.3.1.-)
Gene namesi
Name:SATL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:27992. SATL1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi340562.
OpenTargetsiENSG00000184788.
PharmGKBiPA134969637.

Polymorphism and mutation databases

BioMutaiSATL1.
DMDMi143583359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829281 – 508Spermidine/spermine N(1)-acetyltransferase-like protein 1Add BLAST508

Proteomic databases

PaxDbiQ86VE3.
PRIDEiQ86VE3.

PTM databases

iPTMnetiQ86VE3.
PhosphoSitePlusiQ86VE3.

Expressioni

Gene expression databases

BgeeiENSG00000184788.
CleanExiHS_SATL1.

Organism-specific databases

HPAiHPA060369.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000425421.

Structurei

3D structure databases

ProteinModelPortaliQ86VE3.
SMRiQ86VE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini342 – 508N-acetyltransferasePROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni365 – 366Substrate bindingBy similarity2
Regioni431 – 433Acetyl-CoA bindingBy similarity3
Regioni439 – 444Acetyl-CoA bindingBy similarity6
Regioni463 – 465Substrate bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 336Gln-richAdd BLAST329

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3216. Eukaryota.
COG0454. LUCA.
GeneTreeiENSGT00440000039972.
HOGENOMiHOG000154259.
HOVERGENiHBG108460.
InParanoidiQ86VE3.
OMAiREPGPSQ.
OrthoDBiEOG091G0UNU.
PhylomeDBiQ86VE3.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPPGMWQPG VQQPGISQQV PSHPDMSQPG MSQQVPSQPG IRQPDTSQSC
60 70 80 90 100
KNQTDMSQPD ANQSSLSDSN QTGIIQPSPS LLGMNQMDMN QWSASLYEMN
110 120 130 140 150
QVDMKQPSMS QAGMRQSGTN LPDINQPGMK QPGTWQLGRS QPGMWPQSLS
160 170 180 190 200
ELVLSEASIS QPGPPQRAPS QSGPRQSSTS QAGTNQSGIS QPVMWQLDMR
210 220 230 240 250
QSGGSQPSMR QVGTSQSGTS QIGMSQPGTW QTGLSQPVPR QPNKSPPGMW
260 270 280 290 300
QRGMWQPGMS QQVPSQLGMR QPGTSQSSKN QTGMSHPGRG QPGIWEPGPS
310 320 330 340 350
QPGLSQQDLN QLVLSQPGLS QPGRSQPSVS QMGMRQTSMD YFQIRHAEAG
360 370 380 390 400
DCPEILRLIK ELAACENMLD AMELTAADLL RDGFGDNPLF YCLIAEVNDQ
410 420 430 440 450
QKPSGKLTVG FAMYYFTYDS WTGKVLYLED FYVTQAYQGL GIGAEMLKRL
460 470 480 490 500
SQIAITTQCN CMHFLVVIWN QASINYYTSR GALDLSSEEG WHLFRFNREE

LLDMAWEE
Length:508
Mass (Da):55,833
Last modified:April 3, 2007 - v3
Checksum:iFB45D4AEB625A024
GO
Isoform 2 (identifier: Q86VE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-445: GLGIGAE → DSHHNSM
     446-508: Missing.

Show »
Length:445
Mass (Da):48,551
Checksum:i22CEB636BB70165E
GO
Isoform 3 (identifier: Q86VE3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNQSGTNQSS...SQPVLRQPNM
     439-445: GLGIGAE → DSHHNSM
     446-508: Missing.

Note: No experimental confirmation available.
Show »
Length:632
Mass (Da):68,530
Checksum:i53B23E9AB1BEEB0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239P → L in AAI26402 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03143892W → R.1 PublicationCorresponds to variant rs10126146dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556741M → MNQSGTNQSSLSDSNQAGIN QPSTNSLGMNQMDMNQGSAS LYEMNQVDMKQPSMSQAGMR QSGTNLPDINQPDMKQPDTW QLGRSQPGMLQQELSQLVLS KAGISQPDPSQPGPSQSGPS QSRMRQIGTNQSGMSQPVMQ QLDSQSGGSQPSMRQVGTSQ LGTSQIGMSQPGTWQTGLSQ PVLRQPNM in isoform 3. Curated1
Alternative sequenceiVSP_024253439 – 445GLGIGAE → DSHHNSM in isoform 2 and isoform 3. 1 Publication7
Alternative sequenceiVSP_024254446 – 508Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83820 Genomic DNA. No translation available.
Z99571 Genomic DNA. No translation available.
BC043215 mRNA. Translation: AAH43215.2.
BC126401 mRNA. Translation: AAI26402.1.
CCDSiCCDS35343.2. [Q86VE3-3]
RefSeqiNP_001012998.2. NM_001012980.2. [Q86VE3-3]
UniGeneiHs.640783.

Genome annotation databases

EnsembliENST00000395409; ENSP00000378804; ENSG00000184788. [Q86VE3-1]
ENST00000509231; ENSP00000425421; ENSG00000184788. [Q86VE3-3]
GeneIDi340562.
KEGGihsa:340562.
UCSCiuc004een.4. human. [Q86VE3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83820 Genomic DNA. No translation available.
Z99571 Genomic DNA. No translation available.
BC043215 mRNA. Translation: AAH43215.2.
BC126401 mRNA. Translation: AAI26402.1.
CCDSiCCDS35343.2. [Q86VE3-3]
RefSeqiNP_001012998.2. NM_001012980.2. [Q86VE3-3]
UniGeneiHs.640783.

3D structure databases

ProteinModelPortaliQ86VE3.
SMRiQ86VE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000425421.

PTM databases

iPTMnetiQ86VE3.
PhosphoSitePlusiQ86VE3.

Polymorphism and mutation databases

BioMutaiSATL1.
DMDMi143583359.

Proteomic databases

PaxDbiQ86VE3.
PRIDEiQ86VE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395409; ENSP00000378804; ENSG00000184788. [Q86VE3-1]
ENST00000509231; ENSP00000425421; ENSG00000184788. [Q86VE3-3]
GeneIDi340562.
KEGGihsa:340562.
UCSCiuc004een.4. human. [Q86VE3-1]

Organism-specific databases

CTDi340562.
DisGeNETi340562.
GeneCardsiSATL1.
HGNCiHGNC:27992. SATL1.
HPAiHPA060369.
neXtProtiNX_Q86VE3.
OpenTargetsiENSG00000184788.
PharmGKBiPA134969637.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3216. Eukaryota.
COG0454. LUCA.
GeneTreeiENSGT00440000039972.
HOGENOMiHOG000154259.
HOVERGENiHBG108460.
InParanoidiQ86VE3.
OMAiREPGPSQ.
OrthoDBiEOG091G0UNU.
PhylomeDBiQ86VE3.

Miscellaneous databases

GenomeRNAii340562.
PROiQ86VE3.

Gene expression databases

BgeeiENSG00000184788.
CleanExiHS_SATL1.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSATL1_HUMAN
AccessioniPrimary (citable) accession number: Q86VE3
Secondary accession number(s): A0AVK7, E9PB72, Q5H8V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.