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Q86VE3

- SATL1_HUMAN

UniProt

Q86VE3 - SATL1_HUMAN

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Protein

Spermidine/spermine N(1)-acetyltransferase-like protein 1

Gene

SATL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei489 – 4891SubstrateBy similarity

GO - Molecular functioni

  1. N-acetyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine/spermine N(1)-acetyltransferase-like protein 1 (EC:2.3.1.-)
Gene namesi
Name:SATL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:27992. SATL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134969637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Spermidine/spermine N(1)-acetyltransferase-like protein 1PRO_0000282928Add
BLAST

Proteomic databases

PaxDbiQ86VE3.
PRIDEiQ86VE3.

PTM databases

PhosphoSiteiQ86VE3.

Expressioni

Gene expression databases

BgeeiQ86VE3.
CleanExiHS_SATL1.
ExpressionAtlasiQ86VE3. baseline.
GenevestigatoriQ86VE3.

Organism-specific databases

HPAiHPA060369.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329115.

Structurei

3D structure databases

ProteinModelPortaliQ86VE3.
SMRiQ86VE3. Positions 342-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini342 – 508167N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni365 – 3662Substrate bindingBy similarity
Regioni431 – 4333Acetyl-CoA bindingBy similarity
Regioni439 – 4446Acetyl-CoA bindingBy similarity
Regioni463 – 4653Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 336329Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG289508.
GeneTreeiENSGT00440000039972.
HOGENOMiHOG000154259.
HOVERGENiHBG108460.
InParanoidiQ86VE3.
PhylomeDBiQ86VE3.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86VE3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPPGMWQPG VQQPGISQQV PSHPDMSQPG MSQQVPSQPG IRQPDTSQSC
60 70 80 90 100
KNQTDMSQPD ANQSSLSDSN QTGIIQPSPS LLGMNQMDMN QWSASLYEMN
110 120 130 140 150
QVDMKQPSMS QAGMRQSGTN LPDINQPGMK QPGTWQLGRS QPGMWPQSLS
160 170 180 190 200
ELVLSEASIS QPGPPQRAPS QSGPRQSSTS QAGTNQSGIS QPVMWQLDMR
210 220 230 240 250
QSGGSQPSMR QVGTSQSGTS QIGMSQPGTW QTGLSQPVPR QPNKSPPGMW
260 270 280 290 300
QRGMWQPGMS QQVPSQLGMR QPGTSQSSKN QTGMSHPGRG QPGIWEPGPS
310 320 330 340 350
QPGLSQQDLN QLVLSQPGLS QPGRSQPSVS QMGMRQTSMD YFQIRHAEAG
360 370 380 390 400
DCPEILRLIK ELAACENMLD AMELTAADLL RDGFGDNPLF YCLIAEVNDQ
410 420 430 440 450
QKPSGKLTVG FAMYYFTYDS WTGKVLYLED FYVTQAYQGL GIGAEMLKRL
460 470 480 490 500
SQIAITTQCN CMHFLVVIWN QASINYYTSR GALDLSSEEG WHLFRFNREE

LLDMAWEE
Length:508
Mass (Da):55,833
Last modified:April 3, 2007 - v3
Checksum:iFB45D4AEB625A024
GO
Isoform 2 (identifier: Q86VE3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-445: GLGIGAE → DSHHNSM
     446-508: Missing.

Show »
Length:445
Mass (Da):48,551
Checksum:i22CEB636BB70165E
GO
Isoform 3 (identifier: Q86VE3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNQSGTNQSS...SQPVLRQPNM
     439-445: GLGIGAE → DSHHNSM
     446-508: Missing.

Note: No experimental confirmation available.

Show »
Length:632
Mass (Da):68,530
Checksum:i53B23E9AB1BEEB0B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391P → L in AAI26402. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921W → R.1 Publication
Corresponds to variant rs10126146 [ dbSNP | Ensembl ].
VAR_031438

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MNQSGTNQSSLSDSNQAGIN QPSTNSLGMNQMDMNQGSAS LYEMNQVDMKQPSMSQAGMR QSGTNLPDINQPDMKQPDTW QLGRSQPGMLQQELSQLVLS KAGISQPDPSQPGPSQSGPS QSRMRQIGTNQSGMSQPVMQ QLDSQSGGSQPSMRQVGTSQ LGTSQIGMSQPGTWQTGLSQ PVLRQPNM in isoform 3. CuratedVSP_055674
Alternative sequencei439 – 4457GLGIGAE → DSHHNSM in isoform 2 and isoform 3. 1 PublicationVSP_024253
Alternative sequencei446 – 50863Missing in isoform 2 and isoform 3. 1 PublicationVSP_024254Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83820 Genomic DNA. No translation available.
Z99571 Genomic DNA. No translation available.
BC043215 mRNA. Translation: AAH43215.2.
BC126401 mRNA. Translation: AAI26402.1.
CCDSiCCDS35343.2. [Q86VE3-3]
RefSeqiNP_001012998.2. NM_001012980.2. [Q86VE3-3]
UniGeneiHs.640783.

Genome annotation databases

EnsembliENST00000395409; ENSP00000378804; ENSG00000184788. [Q86VE3-1]
ENST00000509231; ENSP00000425421; ENSG00000184788. [Q86VE3-3]
GeneIDi340562.
KEGGihsa:340562.

Polymorphism databases

DMDMi143583359.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83820 Genomic DNA. No translation available.
Z99571 Genomic DNA. No translation available.
BC043215 mRNA. Translation: AAH43215.2 .
BC126401 mRNA. Translation: AAI26402.1 .
CCDSi CCDS35343.2. [Q86VE3-3 ]
RefSeqi NP_001012998.2. NM_001012980.2. [Q86VE3-3 ]
UniGenei Hs.640783.

3D structure databases

ProteinModelPortali Q86VE3.
SMRi Q86VE3. Positions 342-508.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000329115.

PTM databases

PhosphoSitei Q86VE3.

Polymorphism databases

DMDMi 143583359.

Proteomic databases

PaxDbi Q86VE3.
PRIDEi Q86VE3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395409 ; ENSP00000378804 ; ENSG00000184788 . [Q86VE3-1 ]
ENST00000509231 ; ENSP00000425421 ; ENSG00000184788 . [Q86VE3-3 ]
GeneIDi 340562.
KEGGi hsa:340562.

Organism-specific databases

CTDi 340562.
GeneCardsi GC0XM084347.
HGNCi HGNC:27992. SATL1.
HPAi HPA060369.
neXtProti NX_Q86VE3.
PharmGKBi PA134969637.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289508.
GeneTreei ENSGT00440000039972.
HOGENOMi HOG000154259.
HOVERGENi HBG108460.
InParanoidi Q86VE3.
PhylomeDBi Q86VE3.

Miscellaneous databases

GenomeRNAii 340562.
NextBioi 97935.
PROi Q86VE3.

Gene expression databases

Bgeei Q86VE3.
CleanExi HS_SATL1.
ExpressionAtlasi Q86VE3. baseline.
Genevestigatori Q86VE3.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-92.
    Tissue: Testis.

Entry informationi

Entry nameiSATL1_HUMAN
AccessioniPrimary (citable) accession number: Q86VE3
Secondary accession number(s): A0AVK7, E9PB72, Q5H8V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3