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Q86VE3

- SATL1_HUMAN

UniProt

Q86VE3 - SATL1_HUMAN

Protein

Spermidine/spermine N(1)-acetyltransferase-like protein 1

Gene

SATL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 3 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei489 – 4891SubstrateBy similarity

    GO - Molecular functioni

    1. N-acetyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spermidine/spermine N(1)-acetyltransferase-like protein 1 (EC:2.3.1.-)
    Gene namesi
    Name:SATL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:27992. SATL1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134969637.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Spermidine/spermine N(1)-acetyltransferase-like protein 1PRO_0000282928Add
    BLAST

    Proteomic databases

    PaxDbiQ86VE3.
    PRIDEiQ86VE3.

    PTM databases

    PhosphoSiteiQ86VE3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86VE3.
    BgeeiQ86VE3.
    CleanExiHS_SATL1.
    GenevestigatoriQ86VE3.

    Organism-specific databases

    HPAiHPA060369.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000329115.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86VE3.
    SMRiQ86VE3. Positions 342-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini342 – 508167N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni365 – 3662Substrate bindingBy similarity
    Regioni431 – 4333Acetyl-CoA bindingBy similarity
    Regioni439 – 4446Acetyl-CoA bindingBy similarity
    Regioni463 – 4653Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi8 – 336329Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the acetyltransferase family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG289508.
    HOGENOMiHOG000154259.
    HOVERGENiHBG108460.
    InParanoidiQ86VE3.
    PhylomeDBiQ86VE3.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86VE3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSPPGMWQPG VQQPGISQQV PSHPDMSQPG MSQQVPSQPG IRQPDTSQSC    50
    KNQTDMSQPD ANQSSLSDSN QTGIIQPSPS LLGMNQMDMN QWSASLYEMN 100
    QVDMKQPSMS QAGMRQSGTN LPDINQPGMK QPGTWQLGRS QPGMWPQSLS 150
    ELVLSEASIS QPGPPQRAPS QSGPRQSSTS QAGTNQSGIS QPVMWQLDMR 200
    QSGGSQPSMR QVGTSQSGTS QIGMSQPGTW QTGLSQPVPR QPNKSPPGMW 250
    QRGMWQPGMS QQVPSQLGMR QPGTSQSSKN QTGMSHPGRG QPGIWEPGPS 300
    QPGLSQQDLN QLVLSQPGLS QPGRSQPSVS QMGMRQTSMD YFQIRHAEAG 350
    DCPEILRLIK ELAACENMLD AMELTAADLL RDGFGDNPLF YCLIAEVNDQ 400
    QKPSGKLTVG FAMYYFTYDS WTGKVLYLED FYVTQAYQGL GIGAEMLKRL 450
    SQIAITTQCN CMHFLVVIWN QASINYYTSR GALDLSSEEG WHLFRFNREE 500
    LLDMAWEE 508
    Length:508
    Mass (Da):55,833
    Last modified:April 3, 2007 - v3
    Checksum:iFB45D4AEB625A024
    GO
    Isoform 2 (identifier: Q86VE3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         439-445: GLGIGAE → DSHHNSM
         446-508: Missing.

    Show »
    Length:445
    Mass (Da):48,551
    Checksum:i22CEB636BB70165E
    GO
    Isoform 3 (identifier: Q86VE3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MNQSGTNQSS...SQPVLRQPNM
         439-445: GLGIGAE → DSHHNSM
         446-508: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:632
    Mass (Da):68,530
    Checksum:i53B23E9AB1BEEB0B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti239 – 2391P → L in AAI26402. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921W → R.1 Publication
    Corresponds to variant rs10126146 [ dbSNP | Ensembl ].
    VAR_031438

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MNQSGTNQSSLSDSNQAGIN QPSTNSLGMNQMDMNQGSAS LYEMNQVDMKQPSMSQAGMR QSGTNLPDINQPDMKQPDTW QLGRSQPGMLQQELSQLVLS KAGISQPDPSQPGPSQSGPS QSRMRQIGTNQSGMSQPVMQ QLDSQSGGSQPSMRQVGTSQ LGTSQIGMSQPGTWQTGLSQ PVLRQPNM in isoform 3. CuratedVSP_055674
    Alternative sequencei439 – 4457GLGIGAE → DSHHNSM in isoform 2 and isoform 3. 1 PublicationVSP_024253
    Alternative sequencei446 – 50863Missing in isoform 2 and isoform 3. 1 PublicationVSP_024254Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z83820 Genomic DNA. No translation available.
    Z99571 Genomic DNA. No translation available.
    BC043215 mRNA. Translation: AAH43215.2.
    BC126401 mRNA. Translation: AAI26402.1.
    RefSeqiNP_001012998.2. NM_001012980.2.
    UniGeneiHs.640783.

    Genome annotation databases

    EnsembliENST00000395409; ENSP00000378804; ENSG00000184788. [Q86VE3-1]
    ENST00000509231; ENSP00000425421; ENSG00000184788. [Q86VE3-3]
    GeneIDi340562.
    KEGGihsa:340562.

    Polymorphism databases

    DMDMi143583359.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z83820 Genomic DNA. No translation available.
    Z99571 Genomic DNA. No translation available.
    BC043215 mRNA. Translation: AAH43215.2 .
    BC126401 mRNA. Translation: AAI26402.1 .
    RefSeqi NP_001012998.2. NM_001012980.2.
    UniGenei Hs.640783.

    3D structure databases

    ProteinModelPortali Q86VE3.
    SMRi Q86VE3. Positions 342-508.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000329115.

    PTM databases

    PhosphoSitei Q86VE3.

    Polymorphism databases

    DMDMi 143583359.

    Proteomic databases

    PaxDbi Q86VE3.
    PRIDEi Q86VE3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395409 ; ENSP00000378804 ; ENSG00000184788 . [Q86VE3-1 ]
    ENST00000509231 ; ENSP00000425421 ; ENSG00000184788 . [Q86VE3-3 ]
    GeneIDi 340562.
    KEGGi hsa:340562.

    Organism-specific databases

    CTDi 340562.
    GeneCardsi GC0XM084347.
    HGNCi HGNC:27992. SATL1.
    HPAi HPA060369.
    neXtProti NX_Q86VE3.
    PharmGKBi PA134969637.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289508.
    HOGENOMi HOG000154259.
    HOVERGENi HBG108460.
    InParanoidi Q86VE3.
    PhylomeDBi Q86VE3.

    Miscellaneous databases

    GenomeRNAii 340562.
    NextBioi 97935.
    PROi Q86VE3.

    Gene expression databases

    ArrayExpressi Q86VE3.
    Bgeei Q86VE3.
    CleanExi HS_SATL1.
    Genevestigatori Q86VE3.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-92.
      Tissue: Testis.

    Entry informationi

    Entry nameiSATL1_HUMAN
    AccessioniPrimary (citable) accession number: Q86VE3
    Secondary accession number(s): A0AVK7, E9PB72, Q5H8V9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3