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Q86VE3 (SATL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Spermidine/spermine N(1)-acetyltransferase-like protein 1

EC=2.3.1.-
Gene names
Name:SATL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the acetyltransferase family.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionN-acetyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86VE3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86VE3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     439-445: GLGIGAE → DSHHNSM
     446-508: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Spermidine/spermine N(1)-acetyltransferase-like protein 1
PRO_0000282928

Regions

Domain342 – 508167N-acetyltransferase
Region365 – 3662Substrate binding By similarity
Region431 – 4333Acetyl-CoA binding By similarity
Region439 – 4446Acetyl-CoA binding By similarity
Region463 – 4653Substrate binding By similarity
Compositional bias8 – 336329Gln-rich

Sites

Binding site4891Substrate By similarity

Natural variations

Alternative sequence439 – 4457GLGIGAE → DSHHNSM in isoform 2.
VSP_024253
Alternative sequence446 – 50863Missing in isoform 2.
VSP_024254
Natural variant921W → R. Ref.2
Corresponds to variant rs10126146 [ dbSNP | Ensembl ].
VAR_031438

Experimental info

Sequence conflict2391P → L in AAI26402. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 3.
Checksum: FB45D4AEB625A024

FASTA50855,833
        10         20         30         40         50         60 
MSPPGMWQPG VQQPGISQQV PSHPDMSQPG MSQQVPSQPG IRQPDTSQSC KNQTDMSQPD 

        70         80         90        100        110        120 
ANQSSLSDSN QTGIIQPSPS LLGMNQMDMN QWSASLYEMN QVDMKQPSMS QAGMRQSGTN 

       130        140        150        160        170        180 
LPDINQPGMK QPGTWQLGRS QPGMWPQSLS ELVLSEASIS QPGPPQRAPS QSGPRQSSTS 

       190        200        210        220        230        240 
QAGTNQSGIS QPVMWQLDMR QSGGSQPSMR QVGTSQSGTS QIGMSQPGTW QTGLSQPVPR 

       250        260        270        280        290        300 
QPNKSPPGMW QRGMWQPGMS QQVPSQLGMR QPGTSQSSKN QTGMSHPGRG QPGIWEPGPS 

       310        320        330        340        350        360 
QPGLSQQDLN QLVLSQPGLS QPGRSQPSVS QMGMRQTSMD YFQIRHAEAG DCPEILRLIK 

       370        380        390        400        410        420 
ELAACENMLD AMELTAADLL RDGFGDNPLF YCLIAEVNDQ QKPSGKLTVG FAMYYFTYDS 

       430        440        450        460        470        480 
WTGKVLYLED FYVTQAYQGL GIGAEMLKRL SQIAITTQCN CMHFLVVIWN QASINYYTSR 

       490        500 
GALDLSSEEG WHLFRFNREE LLDMAWEE 

« Hide

Isoform 2 [UniParc].

Checksum: 22CEB636BB70165E
Show »

FASTA44548,551

References

[1]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-92.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z99571 Genomic DNA. Translation: CAI42723.1.
BC043215 mRNA. Translation: AAH43215.2.
BC126401 mRNA. Translation: AAI26402.1.
RefSeqNP_001012998.2. NM_001012980.2.
UniGeneHs.640783.

3D structure databases

ProteinModelPortalQ86VE3.
SMRQ86VE3. Positions 342-508.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000329115.

PTM databases

PhosphoSiteQ86VE3.

Polymorphism databases

DMDM143583359.

Proteomic databases

PaxDbQ86VE3.
PRIDEQ86VE3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332921; ENSP00000329115; ENSG00000184788. [Q86VE3-2]
ENST00000395409; ENSP00000378804; ENSG00000184788. [Q86VE3-1]
GeneID340562.
KEGGhsa:340562.

Organism-specific databases

CTD340562.
GeneCardsGC0XM084347.
HGNCHGNC:27992. SATL1.
HPAHPA060369.
neXtProtNX_Q86VE3.
PharmGKBPA134969637.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG289508.
HOGENOMHOG000154259.
HOVERGENHBG108460.
InParanoidQ86VE3.
PhylomeDBQ86VE3.

Gene expression databases

ArrayExpressQ86VE3.
BgeeQ86VE3.
CleanExHS_SATL1.
GenevestigatorQ86VE3.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi340562.
NextBio97935.
PROQ86VE3.

Entry information

Entry nameSATL1_HUMAN
AccessionPrimary (citable) accession number: Q86VE3
Secondary accession number(s): A0AVK7, Q5H8V9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM