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Protein

Myb-related transcription factor, partner of profilin

Gene

MYPOP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-related transcription factor, partner of profilin
Alternative name(s):
Myb-related protein p42POP
Partner of profilin
Gene namesi
Name:MYPOP
Synonyms:P42POP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20178. MYPOP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723403.

Polymorphism and mutation databases

BioMutaiMYPOP.
DMDMi74759426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Myb-related transcription factor, partner of profilinPRO_0000344799Add
BLAST

Proteomic databases

EPDiQ86VE0.
MaxQBiQ86VE0.
PaxDbiQ86VE0.
PRIDEiQ86VE0.

PTM databases

PhosphoSiteiQ86VE0.

Expressioni

Gene expression databases

BgeeiQ86VE0.
GenevisibleiQ86VE0. HS.

Interactioni

Subunit structurei

Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ86VE0. 1 interaction.
STRINGi9606.ENSP00000325402.

Structurei

3D structure databases

ProteinModelPortaliQ86VE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8473Myb-likePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi83 – 864Nuclear localization signalBy similarity
Motifi382 – 3854Nuclear localization signalBy similarity
Motifi390 – 3934Nuclear localization signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi136 – 380245Pro-richAdd
BLAST

Domaini

The proline-rich region is required for PFN1 interaction.By similarity

Sequence similaritiesi

Contains 1 Myb-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEV7. Eukaryota.
ENOG410XX4G. LUCA.
GeneTreeiENSGT00450000040421.
HOGENOMiHOG000113710.
InParanoidiQ86VE0.
OMAiACPQRYV.
OrthoDBiEOG7PZRZQ.
PhylomeDBiQ86VE0.
TreeFamiTF338618.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR028002. Myb_DNA-bind_5.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
PROSITEiPS50090. MYB_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAAAGEAE ETTRLRKPRF SFEENQILIR EVRAHYPQLY GAQSRRVSVA
60 70 80 90 100
ERRRVWDGIA AKINGITSWK RTGQEVQKRW NDFKRRTKEK LARVPHSTQG
110 120 130 140 150
AGPAAEDAFS AEEETIFAIL GPGVAAPGAG AGAEEPPAAP SSQPPPPSAC
160 170 180 190 200
PQRYVLSEDR REDRRADTSA HSKAGSSSPE PWARPSCTPQ EGGCPRPKER
210 220 230 240 250
ESPPPSALQP VQLPRLALSP PPPAPPLPPP PPLAQVAPSP PSPPPPPRPP
260 270 280 290 300
PTLSASDPSL DFLRAQQETA NAIRELAGTL RQGLAKLSEA LSALLPLLPG
310 320 330 340 350
TPVDSLPPPL PPPPPPPPPP RPVLPPPAPK VEITPEPVSV VAAVVDGAVV
360 370 380 390
AARGVIIAPR SEEGAPRPPP APLPPHDSPP HKRRKGFPTR KRRGRWKSP
Length:399
Mass (Da):42,508
Last modified:April 26, 2005 - v2
Checksum:iF949A70588E0C454
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044311 mRNA. Translation: AAH44311.2.
CCDSiCCDS33055.1.
RefSeqiNP_001012661.1. NM_001012643.3.
UniGeneiHs.515478.

Genome annotation databases

EnsembliENST00000322217; ENSP00000325402; ENSG00000176182.
GeneIDi339344.
KEGGihsa:339344.
UCSCiuc002pdt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044311 mRNA. Translation: AAH44311.2.
CCDSiCCDS33055.1.
RefSeqiNP_001012661.1. NM_001012643.3.
UniGeneiHs.515478.

3D structure databases

ProteinModelPortaliQ86VE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86VE0. 1 interaction.
STRINGi9606.ENSP00000325402.

PTM databases

PhosphoSiteiQ86VE0.

Polymorphism and mutation databases

BioMutaiMYPOP.
DMDMi74759426.

Proteomic databases

EPDiQ86VE0.
MaxQBiQ86VE0.
PaxDbiQ86VE0.
PRIDEiQ86VE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322217; ENSP00000325402; ENSG00000176182.
GeneIDi339344.
KEGGihsa:339344.
UCSCiuc002pdt.4. human.

Organism-specific databases

CTDi339344.
GeneCardsiMYPOP.
HGNCiHGNC:20178. MYPOP.
neXtProtiNX_Q86VE0.
PharmGKBiPA164723403.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEV7. Eukaryota.
ENOG410XX4G. LUCA.
GeneTreeiENSGT00450000040421.
HOGENOMiHOG000113710.
InParanoidiQ86VE0.
OMAiACPQRYV.
OrthoDBiEOG7PZRZQ.
PhylomeDBiQ86VE0.
TreeFamiTF338618.

Miscellaneous databases

ChiTaRSiMYPOP. human.
GenomeRNAii339344.
NextBioi97360.
PROiQ86VE0.

Gene expression databases

BgeeiQ86VE0.
GenevisibleiQ86VE0. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR028002. Myb_DNA-bind_5.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
PROSITEiPS50090. MYB_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.

Entry informationi

Entry nameiMYPOP_HUMAN
AccessioniPrimary (citable) accession number: Q86VE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 26, 2005
Last modified: March 16, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.