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Protein

Mitochondrial coenzyme A transporter SLC25A42

Gene

SLC25A42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.1 Publication

GO - Molecular functioni

  • adenosine-diphosphatase activity Source: UniProtKB
  • ADP transmembrane transporter activity Source: UniProtKB
  • AMP transmembrane transporter activity Source: UniProtKB
  • ATP transmembrane transporter activity Source: UniProtKB
  • coenzyme A transmembrane transporter activity Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • ADP transport Source: UniProtKB
  • AMP transport Source: UniProtKB
  • ATP transport Source: UniProtKB
  • coenzyme A transmembrane transport Source: UniProtKB
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.12.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial coenzyme A transporter SLC25A42
Alternative name(s):
Solute carrier family 25 member 42
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28380. SLC25A42.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei186 – 20621Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei293 – 31321Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403703.

Polymorphism and mutation databases

BioMutaiSLC25A42.
DMDMi150416122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Mitochondrial coenzyme A transporter SLC25A42PRO_0000292336Add
BLAST

Proteomic databases

MaxQBiQ86VD7.
PaxDbiQ86VD7.
PRIDEiQ86VD7.

PTM databases

iPTMnetiQ86VD7.
PhosphoSiteiQ86VD7.

Expressioni

Gene expression databases

BgeeiQ86VD7.
CleanExiHS_SLC25A42.
ExpressionAtlasiQ86VD7. baseline and differential.
GenevisibleiQ86VD7. HS.

Organism-specific databases

HPAiHPA049449.

Interactioni

Protein-protein interaction databases

BioGridi129877. 2 interactions.
IntActiQ86VD7. 1 interaction.
STRINGi9606.ENSP00000326693.

Structurei

3D structure databases

ProteinModelPortaliQ86VD7.
SMRiQ86VD7. Positions 34-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 11787Solcar 1Add
BLAST
Repeati129 – 21486Solcar 2Add
BLAST
Repeati224 – 31289Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiQ86VD7.
KOiK15085.
OMAiEYSGRPQ.
OrthoDBiEOG7XM2Z1.
PhylomeDBiQ86VD7.
TreeFamiTF314806.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR014762. DNA_mismatch_repair_CS.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86VD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGVKEGPV RLHEDAEAVL SSSVSSKRDH RQVLSSLLSG ALAGALAKTA
60 70 80 90 100
VAPLDRTKII FQVSSKRFSA KEAFRVLYYT YLNEGFLSLW RGNSATMVRV
110 120 130 140 150
VPYAAIQFSA HEEYKRILGS YYGFRGEALP PWPRLFAGAL AGTTAASLTY
160 170 180 190 200
PLDLVRARMA VTPKEMYSNI FHVFIRISRE EGLKTLYHGF MPTVLGVIPY
210 220 230 240 250
AGLSFFTYET LKSLHREYSG RRQPYPFERM IFGACAGLIG QSASYPLDVV
260 270 280 290 300
RRRMQTAGVT GYPRASIART LRTIVREEGA VRGLYKGLSM NWVKGPIAVG
310
ISFTTFDLMQ ILLRHLQS
Length:318
Mass (Da):35,409
Last modified:June 26, 2007 - v2
Checksum:iD42F26C200D3EACF
GO

Sequence cautioni

The sequence AAC02758.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391S → P.1 Publication
Corresponds to variant rs17854359 [ dbSNP | Ensembl ].
VAR_032970
Natural varianti312 – 3121L → M.2 Publications
Corresponds to variant rs17854358 [ dbSNP | Ensembl ].
VAR_032971

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN356975 mRNA. Translation: CAX94853.1.
AC002126 Genomic DNA. Translation: AAB86983.1.
AC004143 Genomic DNA. Translation: AAC02758.1. Sequence problems.
BC045598 mRNA. Translation: AAH45598.1.
CCDSiCCDS32966.1.
RefSeqiNP_848621.2. NM_178526.4.
XP_005259918.1. XM_005259861.2.
XP_011526239.1. XM_011527937.1.
UniGeneiHs.303669.

Genome annotation databases

EnsembliENST00000318596; ENSP00000326693; ENSG00000181035.
GeneIDi284439.
KEGGihsa:284439.
UCSCiuc002nlf.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN356975 mRNA. Translation: CAX94853.1.
AC002126 Genomic DNA. Translation: AAB86983.1.
AC004143 Genomic DNA. Translation: AAC02758.1. Sequence problems.
BC045598 mRNA. Translation: AAH45598.1.
CCDSiCCDS32966.1.
RefSeqiNP_848621.2. NM_178526.4.
XP_005259918.1. XM_005259861.2.
XP_011526239.1. XM_011527937.1.
UniGeneiHs.303669.

3D structure databases

ProteinModelPortaliQ86VD7.
SMRiQ86VD7. Positions 34-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129877. 2 interactions.
IntActiQ86VD7. 1 interaction.
STRINGi9606.ENSP00000326693.

Protein family/group databases

TCDBi2.A.29.12.2. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ86VD7.
PhosphoSiteiQ86VD7.

Polymorphism and mutation databases

BioMutaiSLC25A42.
DMDMi150416122.

Proteomic databases

MaxQBiQ86VD7.
PaxDbiQ86VD7.
PRIDEiQ86VD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318596; ENSP00000326693; ENSG00000181035.
GeneIDi284439.
KEGGihsa:284439.
UCSCiuc002nlf.5. human.

Organism-specific databases

CTDi284439.
GeneCardsiSLC25A42.
H-InvDBHIX0027465.
HGNCiHGNC:28380. SLC25A42.
HPAiHPA049449.
MIMi610823. gene.
neXtProtiNX_Q86VD7.
PharmGKBiPA162403703.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiQ86VD7.
KOiK15085.
OMAiEYSGRPQ.
OrthoDBiEOG7XM2Z1.
PhylomeDBiQ86VD7.
TreeFamiTF314806.

Miscellaneous databases

GenomeRNAii284439.
PROiQ86VD7.
SOURCEiSearch...

Gene expression databases

BgeeiQ86VD7.
CleanExiHS_SLC25A42.
ExpressionAtlasiQ86VD7. baseline and differential.
GenevisibleiQ86VD7. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR014762. DNA_mismatch_repair_CS.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria."
    Fiermonte G., Paradies E., Todisco S., Marobbio C.M., Palmieri F.
    J. Biol. Chem. 284:18152-18159(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-312, FUNCTION, SUBCELLULAR LOCATION.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-39 AND MET-312.
    Tissue: Brain.
  4. "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
    Haitina T., Lindblom J., Renstroem T., Fredriksson R.
    Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS2542_HUMAN
AccessioniPrimary (citable) accession number: Q86VD7
Secondary accession number(s): D2T2J5, O14553, O43378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.