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Protein

Mitochondrial coenzyme A transporter SLC25A42

Gene

SLC25A42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.1 Publication

GO - Molecular functioni

  • adenosine-diphosphatase activity Source: UniProtKB
  • ADP transmembrane transporter activity Source: UniProtKB
  • AMP transmembrane transporter activity Source: UniProtKB
  • ATP transmembrane transporter activity Source: UniProtKB
  • coenzyme A transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • ADP transport Source: UniProtKB
  • AMP transport Source: UniProtKB
  • ATP transport Source: UniProtKB
  • coenzyme A transmembrane transport Source: UniProtKB
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.12.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial coenzyme A transporter SLC25A42
Alternative name(s):
Solute carrier family 25 member 42
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28380. SLC25A42.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei135 – 155Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei186 – 206Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • mitochondrial inner membrane Source: GO_Central
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi284439.
OpenTargetsiENSG00000181035.
PharmGKBiPA162403703.

Polymorphism and mutation databases

BioMutaiSLC25A42.
DMDMi150416122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002923361 – 318Mitochondrial coenzyme A transporter SLC25A42Add BLAST318

Proteomic databases

MaxQBiQ86VD7.
PaxDbiQ86VD7.
PeptideAtlasiQ86VD7.
PRIDEiQ86VD7.

PTM databases

iPTMnetiQ86VD7.
PhosphoSitePlusiQ86VD7.

Expressioni

Gene expression databases

BgeeiENSG00000181035.
CleanExiHS_SLC25A42.
ExpressionAtlasiQ86VD7. baseline and differential.
GenevisibleiQ86VD7. HS.

Organism-specific databases

HPAiHPA049449.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153234EBI-6598313,EBI-948001

Protein-protein interaction databases

BioGridi129877. 2 interactors.
IntActiQ86VD7. 6 interactors.
STRINGi9606.ENSP00000326693.

Structurei

3D structure databases

ProteinModelPortaliQ86VD7.
SMRiQ86VD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 117Solcar 1Add BLAST87
Repeati129 – 214Solcar 2Add BLAST86
Repeati224 – 312Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00880000137904.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiQ86VD7.
KOiK15085.
OMAiTHDTVGD.
OrthoDBiEOG091G0C8S.
PhylomeDBiQ86VD7.
TreeFamiTF314806.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR014762. DNA_mismatch_repair_CS.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q86VD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGVKEGPV RLHEDAEAVL SSSVSSKRDH RQVLSSLLSG ALAGALAKTA
60 70 80 90 100
VAPLDRTKII FQVSSKRFSA KEAFRVLYYT YLNEGFLSLW RGNSATMVRV
110 120 130 140 150
VPYAAIQFSA HEEYKRILGS YYGFRGEALP PWPRLFAGAL AGTTAASLTY
160 170 180 190 200
PLDLVRARMA VTPKEMYSNI FHVFIRISRE EGLKTLYHGF MPTVLGVIPY
210 220 230 240 250
AGLSFFTYET LKSLHREYSG RRQPYPFERM IFGACAGLIG QSASYPLDVV
260 270 280 290 300
RRRMQTAGVT GYPRASIART LRTIVREEGA VRGLYKGLSM NWVKGPIAVG
310
ISFTTFDLMQ ILLRHLQS
Length:318
Mass (Da):35,409
Last modified:June 26, 2007 - v2
Checksum:iD42F26C200D3EACF
GO

Sequence cautioni

The sequence AAC02758 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03297039S → P1 PublicationCorresponds to variant dbSNP:rs17854359Ensembl.1
Natural variantiVAR_032971312L → M2 PublicationsCorresponds to variant dbSNP:rs17854358Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN356975 mRNA. Translation: CAX94853.1.
AC002126 Genomic DNA. Translation: AAB86983.1.
AC004143 Genomic DNA. Translation: AAC02758.1. Sequence problems.
BC045598 mRNA. Translation: AAH45598.1.
CCDSiCCDS32966.1.
RefSeqiNP_001308473.1. NM_001321544.1.
NP_848621.2. NM_178526.4.
XP_005259918.1. XM_005259861.3.
XP_011526239.1. XM_011527937.2.
UniGeneiHs.303669.

Genome annotation databases

EnsembliENST00000318596; ENSP00000326693; ENSG00000181035.
GeneIDi284439.
KEGGihsa:284439.
UCSCiuc002nlf.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS2542_HUMAN
AccessioniPrimary (citable) accession number: Q86VD7
Secondary accession number(s): D2T2J5, O14553, O43378
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: August 30, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families