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Protein

MORC family CW-type zinc finger protein 1

Gene

MORC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for spermatogenesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri477 – 53155CW-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MORC family CW-type zinc finger protein 1
Alternative name(s):
Cancer/testis antigen 33
Short name:
CT33
Gene namesi
Name:MORC1Imported
Synonyms:MORCImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:7198. MORC1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30906.

Polymorphism and mutation databases

BioMutaiMORC1.
DMDMi269849621.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984MORC family CW-type zinc finger protein 1PRO_0000248241Add
BLAST

Proteomic databases

EPDiQ86VD1.
PaxDbiQ86VD1.
PeptideAtlasiQ86VD1.
PRIDEiQ86VD1.

PTM databases

iPTMnetiQ86VD1.
PhosphoSiteiQ86VD1.

Expressioni

Gene expression databases

BgeeiQ86VD1.
CleanExiHS_MORC1.
GenevisibleiQ86VD1. HS.

Organism-specific databases

HPAiHPA036413.

Interactioni

Protein-protein interaction databases

BioGridi118026. 5 interactions.
STRINGi9606.ENSP00000232603.

Structurei

3D structure databases

ProteinModelPortaliQ86VD1.
SMRiQ86VD1. Positions 482-528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili284 – 35370Sequence analysisAdd
BLAST
Coiled coili737 – 76125Sequence analysisAdd
BLAST
Coiled coili900 – 93435Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 CW-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri477 – 53155CW-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1845. Eukaryota.
ENOG411033B. LUCA.
GeneTreeiENSGT00530000062983.
HOGENOMiHOG000060084.
HOVERGENiHBG056877.
InParanoidiQ86VD1.
OMAiCLYRPRK.
OrthoDBiEOG71ZP0X.
PhylomeDBiQ86VD1.
TreeFamiTF329118.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
InterProiIPR003594. HATPase_C.
IPR011124. Znf_CW.
[Graphical view]
PfamiPF07496. zf-CW. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 2 hits.
PROSITEiPS51050. ZF_CW. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDRYPALQR AQLRLDFIHA NSTTHSFLFG ALAELLDNAR DAGAERLDVF
60 70 80 90 100
SVDNEKLQGG FMLCFLDDGC GMSPEEASDI IYFGRSKKRL STLKFIGQYG
110 120 130 140 150
NGLKSGSMRI GKDFILFTKK EETMTCVFFS QTFCEEESLS EVVVPMPSWL
160 170 180 190 200
IRTRESVTDD PQKFAMELSI IYKYSPFKTE AELMQQFDVI YGKCGTLLVI
210 220 230 240 250
YNLKLLLNGE PELDVKTDKE DILMAGALED FPARWSFRAY TSVLYFNPWM
260 270 280 290 300
RIFIQAKRVK TKHLCYCLYR PRKYLYVTSS FKGAFKDEVK KAEEAVKIAE
310 320 330 340 350
SILKEAQIKV NQCDRTSLSS AKDVLQRALE DVEAKQKNLK EKQRELKTAR
360 370 380 390 400
TLSLFYGVNV ENRSQAGMFI YSNNRLIKMH EKVGSQLKLK SLLGAGVVGI
410 420 430 440 450
VNIPLEVMEP SHNKQEFLNV QEYNHLLKVM GQYLVQYCKD TGINNRNLTL
460 470 480 490 500
FCNEFGYQND IDVEKPLNSF QYQRRQAMGI PFIIQCDLCL KWRVLPSSTN
510 520 530 540 550
YQEKEFFDIW ICANNPNRLE NSCHQVECLP SIPLGTMSTI SPSKNEKEKQ
560 570 580 590 600
LRESVIKYQN RLAEQQPQPQ FIPVDEITVT STCLTSAHKE NTKTQKIRLL
610 620 630 640 650
GDDLKHESLS SFELSASRRG QKRNIEETDS DVEYISETKI MKKSMEEKMN
660 670 680 690 700
SQQQRIPVAL PENVKLAERS QRSQIANITT VWRAQPTEGC LKNAQAASWE
710 720 730 740 750
MKRKQSLNFV EECKVLTEDE NTSDSDIILV SDKSNTDVSL KQEKKEIPLL
760 770 780 790 800
NQEKQELCND VLAMKRSSSL PSWKSLLNVP MEDVNLSSGH IARVSVSGSC
810 820 830 840 850
KVASSPASSQ STPVKETVRK LKSKLREILL YFFPEHQLPS ELEEPALSCE
860 870 880 890 900
LEQCPEQMNK KLKMCFNQIQ NTYMVQYEKK IKRKLQSIIY DSNTRGIHNE
910 920 930 940 950
ISLGQCENKR KISEDKLKNL RIKLALLLQK LQLGGPEGDL EQTDTYLEAL
960 970 980
LKEDNLLFQN NLNKVTIDAR HRLPLEKNEK TSEN
Length:984
Mass (Da):112,881
Last modified:November 24, 2009 - v2
Checksum:i613163D31E2317A6
GO
Isoform 2 (identifier: Q86VD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-589: Missing.

Note: No experimental confirmation available.
Show »
Length:963
Mass (Da):110,612
Checksum:i2FC5A04E37E5C650
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651F → C in BAG63883 (PubMed:14702039).Curated
Sequence conflicti692 – 6921K → E in BAG63883 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531T → P.
Corresponds to variant rs35282274 [ dbSNP | Ensembl ].
VAR_051188
Natural varianti322 – 3221K → M.
Corresponds to variant rs17225637 [ dbSNP | Ensembl ].
VAR_051189
Natural varianti462 – 4621D → E.
Corresponds to variant rs3762696 [ dbSNP | Ensembl ].
VAR_059698
Natural varianti470 – 4701F → I.4 Publications
Corresponds to variant rs4855576 [ dbSNP | Ensembl ].
VAR_051190
Natural varianti478 – 4781M → V.
Corresponds to variant rs3762697 [ dbSNP | Ensembl ].
VAR_051191
Natural varianti649 – 6491M → I.
Corresponds to variant rs35421732 [ dbSNP | Ensembl ].
VAR_051192
Natural varianti767 – 7671S → N.
Corresponds to variant rs2290057 [ dbSNP | Ensembl ].
VAR_051193
Natural varianti836 – 8361H → Y.3 Publications
Corresponds to variant rs2593943 [ dbSNP | Ensembl ].
VAR_051194
Natural varianti982 – 9821S → C.
Corresponds to variant rs16855035 [ dbSNP | Ensembl ].
VAR_051195
Natural varianti982 – 9821S → W.
Corresponds to variant rs16855035 [ dbSNP | Ensembl ].
VAR_051196

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei569 – 58921Missing in isoform 2. 1 PublicationVSP_055495Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084946 mRNA. Translation: AAD43004.1.
AK302642 mRNA. Translation: BAG63883.1.
AC016948 Genomic DNA. No translation available.
AC112138 Genomic DNA. No translation available.
BC050307 mRNA. Translation: AAH50307.1.
AL353955 mRNA. Translation: CAB89255.1.
CCDSiCCDS2955.1. [Q86VD1-1]
PIRiT48690.
RefSeqiNP_055244.3. NM_014429.3. [Q86VD1-1]
UniGeneiHs.591296.

Genome annotation databases

EnsembliENST00000232603; ENSP00000232603; ENSG00000114487. [Q86VD1-1]
ENST00000483760; ENSP00000417282; ENSG00000114487. [Q86VD1-2]
GeneIDi27136.
KEGGihsa:27136.
UCSCiuc003dxl.4. human. [Q86VD1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084946 mRNA. Translation: AAD43004.1.
AK302642 mRNA. Translation: BAG63883.1.
AC016948 Genomic DNA. No translation available.
AC112138 Genomic DNA. No translation available.
BC050307 mRNA. Translation: AAH50307.1.
AL353955 mRNA. Translation: CAB89255.1.
CCDSiCCDS2955.1. [Q86VD1-1]
PIRiT48690.
RefSeqiNP_055244.3. NM_014429.3. [Q86VD1-1]
UniGeneiHs.591296.

3D structure databases

ProteinModelPortaliQ86VD1.
SMRiQ86VD1. Positions 482-528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118026. 5 interactions.
STRINGi9606.ENSP00000232603.

PTM databases

iPTMnetiQ86VD1.
PhosphoSiteiQ86VD1.

Polymorphism and mutation databases

BioMutaiMORC1.
DMDMi269849621.

Proteomic databases

EPDiQ86VD1.
PaxDbiQ86VD1.
PeptideAtlasiQ86VD1.
PRIDEiQ86VD1.

Protocols and materials databases

DNASUi27136.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232603; ENSP00000232603; ENSG00000114487. [Q86VD1-1]
ENST00000483760; ENSP00000417282; ENSG00000114487. [Q86VD1-2]
GeneIDi27136.
KEGGihsa:27136.
UCSCiuc003dxl.4. human. [Q86VD1-1]

Organism-specific databases

CTDi27136.
GeneCardsiMORC1.
HGNCiHGNC:7198. MORC1.
HPAiHPA036413.
MIMi603205. gene.
neXtProtiNX_Q86VD1.
PharmGKBiPA30906.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1845. Eukaryota.
ENOG411033B. LUCA.
GeneTreeiENSGT00530000062983.
HOGENOMiHOG000060084.
HOVERGENiHBG056877.
InParanoidiQ86VD1.
OMAiCLYRPRK.
OrthoDBiEOG71ZP0X.
PhylomeDBiQ86VD1.
TreeFamiTF329118.

Miscellaneous databases

GenomeRNAii27136.
PROiQ86VD1.
SOURCEiSearch...

Gene expression databases

BgeeiQ86VD1.
CleanExiHS_MORC1.
GenevisibleiQ86VD1. HS.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
InterProiIPR003594. HATPase_C.
IPR011124. Znf_CW.
[Graphical view]
PfamiPF07496. zf-CW. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 2 hits.
PROSITEiPS51050. ZF_CW. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis."
    Inoue N., Hess K.D., Moreadith R.W., Richardson L.L., Handel M.A., Watson M.L., Zinn A.R.
    Hum. Mol. Genet. 8:1201-1207(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-470 AND TYR-836.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ILE-470 AND TYR-836.
    Tissue: Testis.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-470.
    Tissue: TestisImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-984 (ISOFORM 1), VARIANTS ILE-470 AND TYR-836.
    Tissue: Testis.

Entry informationi

Entry nameiMORC1_HUMAN
AccessioniPrimary (citable) accession number: Q86VD1
Secondary accession number(s): B4DYX1
, E7ERX1, Q7L8E2, Q9NSG7, Q9Y6D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 24, 2009
Last modified: July 6, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.