Q86VB7 (C163A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Scavenger receptor cysteine-rich type 1 protein M130

Alternative name(s):
Hemoglobin scavenger receptor
CD_antigen=CD163

Cleaved into the following chain:

1. Soluble CD163
   Short name=sCD163

Gene names

Name:	CD163
Synonyms:	M130

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. Ref.7 Ref.9 Ref.10 Ref.12 Ref.18 After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. Ref.7 Ref.9 Ref.10 Ref.12 Ref.18
Subunit structure	Interacts with CSNK2B. Ref.9
Subcellular location	Soluble CD163: Secreted Ref.7 Ref.8. Cell membrane; Single-pass type I membrane protein. Note: Isoform 1 and isoform 2 show a lower surface expression when expressed in cells. Ref.7 Ref.8
Tissue specificity	Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood. Ref.7 Ref.10 Ref.18
Induction	Induced by anti-inflammatory mediators such as glucocorticoids, interleukin-6/IL6 and interleukin-10/IL10; suppressed by proinflammatory mediators like bacterial lipopolysaccharides (LPS), IFNG/IFN-gamma and TNF. Ref.7 Ref.8
Domain	The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes. Ref.15
Post-translational modification	A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated Probable. Ref.9
Miscellaneous	Intravenous lipopolysaccharide (LPS) produces a rapid rise of sCD163 in plasma of patient as it induces metalloproteinase-mediated shedding from monocytes surface. Long-term LPS infusion finally increases expression of the membrane-bound form on circulating monocytes. The soluble form (sCD163) in plasma is a novel parameter in diseases affecting macrophage function and monocyte/macrophage load in the body. The concentration of sCD163 is probably reflecting the number of macrophages of the 'alternative macrophage activation' phenotype with a high CD163 expression playing a major role in dampening the inflammatory response and scavenging components of damaged cells. This has initiated a number of clinical studies for evaluation of sCD163 as a disease marker in inflammatory conditions e.g. infection, autoimmune disease, transplantation, atherosclerosis and cancer.
Sequence similarities	Contains 9 SRCR domains.
Caution	It is uncertain whether Met-1 or Met-6 is the initiator.
Biophysicochemical properties	Kinetic parameters: KM=2.0 nM for hemoglobin/haptoglobin of HP*1S phenotype Ref.10 KM=0.2 nM for hemoglobin/haptoglobin of HP*1F phenotype
Sequence caution	The sequence CAA80541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA80542.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA80543.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA80544.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB45233.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Acute phase Inflammatory response
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Non-traceable author statement. Source: UniProtKB integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	scavenger receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86VB7-1)

Also known as: Long tail variant 1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86VB7-2)

Also known as: Long tail variant 2;

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1156: ENSHESADFS...SHTEKENGNL → GLWVLGGSIA...GSLDAYNGQE

Isoform 3 (identifier: Q86VB7-3)

Also known as: Short tail variant;

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1156: ENSHESADFSAAELISVSKFLPISGMEKEAILSHTEKENGNL → GGHSEPH

Isoform 4 (identifier: Q86VB7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     579-579: R → SKTQKTSLIGSYTVKGTGLGSHSCLFLKPCLLPG
     1115-1156: ENSHESADFSAAELISVSKFLPISGMEKEAILSHTEKENGNL → GGHSEPH

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 41	41	Potential
	Chain	42 – 1156	1115	Scavenger receptor cysteine-rich type 1 protein M130		PRO_0000238938
	Chain	42 – ?		Soluble CD163		PRO_0000238939
Regions
	Topological domain	42 – 1050	1009	Extracellular Potential
	Transmembrane	1051 – 1071	21	Helical; Potential
	Topological domain	1072 – 1156	85	Cytoplasmic Potential
	Domain	51 – 152	102	SRCR 1
	Domain	159 – 259	101	SRCR 2
	Domain	266 – 366	101	SRCR 3
	Domain	373 – 473	101	SRCR 4
	Domain	478 – 578	101	SRCR 5
	Domain	583 – 683	101	SRCR 6
	Domain	719 – 819	101	SRCR 7
	Domain	824 – 926	103	SRCR 8
	Domain	929 – 1029	101	SRCR 9
	Motif	1096 – 1099	4	Internalization signal
Sites
	Site	269 – 270	2	Cleavage; in calcium-free condition
	Site	281 – 282	2	Cleavage; in calcium-free condition
	Site	333 – 334	2	Cleavage; in calcium-free condition
	Site	360 – 361	2	Cleavage; in calcium-free condition
Amino acid modifications
	Modified residue	14	1	Phosphoserine By similarity
	Glycosylation	105	1	N-linked (GlcNAc...) Ref.17 Ref.19
	Glycosylation	140	1	N-linked (GlcNAc...) Ref.19
	Glycosylation	767	1	N-linked (GlcNAc...) Ref.19
	Glycosylation	1027	1	N-linked (GlcNAc...) Ref.19
	Disulfide bond	76 ↔ 141		By similarity
	Disulfide bond	89 ↔ 151		By similarity
	Disulfide bond	120 ↔ 130		By similarity
	Disulfide bond	184 ↔ 248		By similarity
	Disulfide bond	197 ↔ 258		By similarity
	Disulfide bond	228 ↔ 238		By similarity
	Disulfide bond	291 ↔ 355		By similarity
	Disulfide bond	304 ↔ 365		By similarity
	Disulfide bond	335 ↔ 345		By similarity
	Disulfide bond	398 ↔ 462		By similarity
	Disulfide bond	411 ↔ 472		By similarity
	Disulfide bond	442 ↔ 452		By similarity
	Disulfide bond	503 ↔ 567		By similarity
	Disulfide bond	516 ↔ 577		By similarity
	Disulfide bond	547 ↔ 557		By similarity
	Disulfide bond	608 ↔ 672		By similarity
	Disulfide bond	621 ↔ 682		By similarity
	Disulfide bond	652 ↔ 662		By similarity
	Disulfide bond	744 ↔ 808		By similarity
	Disulfide bond	757 ↔ 818		By similarity
	Disulfide bond	788 ↔ 798		By similarity
	Disulfide bond	864 ↔ 925		By similarity
	Disulfide bond	895 ↔ 905		By similarity
	Disulfide bond	954 ↔ 1018		By similarity
	Disulfide bond	967 ↔ 1028		By similarity
	Disulfide bond	998 ↔ 1008		By similarity
Natural variations
	Alternative sequence	579	1	R → SKTQKTSLIGSYTVKGTGLG SHSCLFLKPCLLPG in isoform 4.		VSP_019013
	Alternative sequence	1115 – 1156	42	ENSHE…ENGNL → GLWVLGGSIAQGFRSVAAVE AQTFYFDKQLKKSKNVIGSL DAYNGQE in isoform 2.		VSP_019014
	Alternative sequence	1115 – 1156	42	ENSHE…ENGNL → GGHSEPH in isoform 3 and isoform 4.		VSP_019015
	Natural variant	342	1	I → V. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs4883263 [ dbSNP | Ensembl ].		VAR_026574
Experimental info
	Mutagenesis	1072	1	T → A: Impaired phosphorylation by PRKCA. Ref.9
	Mutagenesis	1084	1	S → A: Impaired phosphorylation by PRKCA. Ref.9
	Mutagenesis	1096	1	Y → A: Massive decrease of endocytotic activity. Ref.18

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long tail variant 1) [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 57B49F76DA6C96EB	FASTA	1,156	125,451
	10 20 30 40 50 60 MSKLRMVLLE DSGSADFRRH FVNLSPFTIT VVLLLSACFV TSSLGGTDKE LRLVDGENKC 70 80 90 100 110 120 SGRVEVKVQE EWGTVCNNGW SMEAVSVICN QLGCPTAIKA PGWANSSAGS GRIWMDHVSC 130 140 150 160 170 180 RGNESALWDC KHDGWGKHSN CTHQQDAGVT CSDGSNLEMR LTRGGNMCSG RIEIKFQGRW 190 200 210 220 230 240 GTVCDDNFNI DHASVICRQL ECGSAVSFSG SSNFGEGSGP IWFDDLICNG NESALWNCKH 250 260 270 280 290 300 QGWGKHNCDH AEDAGVICSK GADLSLRLVD GVTECSGRLE VRFQGEWGTI CDDGWDSYDA 310 320 330 340 350 360 AVACKQLGCP TAVTAIGRVN ASKGFGHIWL DSVSCQGHEP AIWQCKHHEW GKHYCNHNED 370 380 390 400 410 420 AGVTCSDGSD LELRLRGGGS RCAGTVEVEI QRLLGKVCDR GWGLKEADVV CRQLGCGSAL 430 440 450 460 470 480 KTSYQVYSKI QATNTWLFLS SCNGNETSLW DCKNWQWGGL TCDHYEEAKI TCSAHREPRL 490 500 510 520 530 540 VGGDIPCSGR VEVKHGDTWG SICDSDFSLE AASVLCRELQ CGTVVSILGG AHFGEGNGQI 550 560 570 580 590 600 WAEEFQCEGH ESHLSLCPVA PRPEGTCSHS RDVGVVCSRY TEIRLVNGKT PCEGRVELKT 610 620 630 640 650 660 LGAWGSLCNS HWDIEDAHVL CQQLKCGVAL STPGGARFGK GNGQIWRHMF HCTGTEQHMG 670 680 690 700 710 720 DCPVTALGAS LCPSEQVASV ICSGNQSQTL SSCNSSSLGP TRPTIPEESA VACIESGQLR 730 740 750 760 770 780 LVNGGGRCAG RVEIYHEGSW GTICDDSWDL SDAHVVCRQL GCGEAINATG SAHFGEGTGP 790 800 810 820 830 840 IWLDEMKCNG KESRIWQCHS HGWGQQNCRH KEDAGVICSE FMSLRLTSEA SREACAGRLE 850 860 870 880 890 900 VFYNGAWGTV GKSSMSETTV GVVCRQLGCA DKGKINPASL DKAMSIPMWV DNVQCPKGPD 910 920 930 940 950 960 TLWQCPSSPW EKRLASPSEE TWITCDNKIR LQEGPTSCSG RVEIWHGGSW GTVCDDSWDL 970 980 990 1000 1010 1020 DDAQVVCQQL GCGPALKAFK EAEFGQGTGP IWLNEVKCKG NESSLWDCPA RRWGHSECGH 1030 1040 1050 1060 1070 1080 KEDAAVNCTD ISVQKTPQKA TTGRSSRQSS FIAVGILGVV LLAIFVALFF LTKKRRQRQR 1090 1100 1110 1120 1130 1140 LAVSSRGENL VHQIQYREMN SCLNADDLDL MNSSENSHES ADFSAAELIS VSKFLPISGM 1150 EKEAILSHTE KENGNL
	Isoform 2 (Long tail variant 2) [UniParc]. Checksum: DD1C93863FD07979	FASTA	1,161	125,982
	10 20 30 40 50 60 MSKLRMVLLE DSGSADFRRH FVNLSPFTIT VVLLLSACFV TSSLGGTDKE LRLVDGENKC 70 80 90 100 110 120 SGRVEVKVQE EWGTVCNNGW SMEAVSVICN QLGCPTAIKA PGWANSSAGS GRIWMDHVSC 130 140 150 160 170 180 RGNESALWDC KHDGWGKHSN CTHQQDAGVT CSDGSNLEMR LTRGGNMCSG RIEIKFQGRW 190 200 210 220 230 240 GTVCDDNFNI DHASVICRQL ECGSAVSFSG SSNFGEGSGP IWFDDLICNG NESALWNCKH 250 260 270 280 290 300 QGWGKHNCDH AEDAGVICSK GADLSLRLVD GVTECSGRLE VRFQGEWGTI CDDGWDSYDA 310 320 330 340 350 360 AVACKQLGCP TAVTAIGRVN ASKGFGHIWL DSVSCQGHEP AIWQCKHHEW GKHYCNHNED 370 380 390 400 410 420 AGVTCSDGSD LELRLRGGGS RCAGTVEVEI QRLLGKVCDR GWGLKEADVV CRQLGCGSAL 430 440 450 460 470 480 KTSYQVYSKI QATNTWLFLS SCNGNETSLW DCKNWQWGGL TCDHYEEAKI TCSAHREPRL 490 500 510 520 530 540 VGGDIPCSGR VEVKHGDTWG SICDSDFSLE AASVLCRELQ CGTVVSILGG AHFGEGNGQI 550 560 570 580 590 600 WAEEFQCEGH ESHLSLCPVA PRPEGTCSHS RDVGVVCSRY TEIRLVNGKT PCEGRVELKT 610 620 630 640 650 660 LGAWGSLCNS HWDIEDAHVL CQQLKCGVAL STPGGARFGK GNGQIWRHMF HCTGTEQHMG 670 680 690 700 710 720 DCPVTALGAS LCPSEQVASV ICSGNQSQTL SSCNSSSLGP TRPTIPEESA VACIESGQLR 730 740 750 760 770 780 LVNGGGRCAG RVEIYHEGSW GTICDDSWDL SDAHVVCRQL GCGEAINATG SAHFGEGTGP 790 800 810 820 830 840 IWLDEMKCNG KESRIWQCHS HGWGQQNCRH KEDAGVICSE FMSLRLTSEA SREACAGRLE 850 860 870 880 890 900 VFYNGAWGTV GKSSMSETTV GVVCRQLGCA DKGKINPASL DKAMSIPMWV DNVQCPKGPD 910 920 930 940 950 960 TLWQCPSSPW EKRLASPSEE TWITCDNKIR LQEGPTSCSG RVEIWHGGSW GTVCDDSWDL 970 980 990 1000 1010 1020 DDAQVVCQQL GCGPALKAFK EAEFGQGTGP IWLNEVKCKG NESSLWDCPA RRWGHSECGH 1030 1040 1050 1060 1070 1080 KEDAAVNCTD ISVQKTPQKA TTGRSSRQSS FIAVGILGVV LLAIFVALFF LTKKRRQRQR 1090 1100 1110 1120 1130 1140 LAVSSRGENL VHQIQYREMN SCLNADDLDL MNSSGLWVLG GSIAQGFRSV AAVEAQTFYF 1150 1160 DKQLKKSKNV IGSLDAYNGQ E
	Isoform 3 (Short tail variant) [UniParc]. Checksum: 31279FC947960606	FASTA	1,121	121,609
	10 20 30 40 50 60 MSKLRMVLLE DSGSADFRRH FVNLSPFTIT VVLLLSACFV TSSLGGTDKE LRLVDGENKC 70 80 90 100 110 120 SGRVEVKVQE EWGTVCNNGW SMEAVSVICN QLGCPTAIKA PGWANSSAGS GRIWMDHVSC 130 140 150 160 170 180 RGNESALWDC KHDGWGKHSN CTHQQDAGVT CSDGSNLEMR LTRGGNMCSG RIEIKFQGRW 190 200 210 220 230 240 GTVCDDNFNI DHASVICRQL ECGSAVSFSG SSNFGEGSGP IWFDDLICNG NESALWNCKH 250 260 270 280 290 300 QGWGKHNCDH AEDAGVICSK GADLSLRLVD GVTECSGRLE VRFQGEWGTI CDDGWDSYDA 310 320 330 340 350 360 AVACKQLGCP TAVTAIGRVN ASKGFGHIWL DSVSCQGHEP AIWQCKHHEW GKHYCNHNED 370 380 390 400 410 420 AGVTCSDGSD LELRLRGGGS RCAGTVEVEI QRLLGKVCDR GWGLKEADVV CRQLGCGSAL 430 440 450 460 470 480 KTSYQVYSKI QATNTWLFLS SCNGNETSLW DCKNWQWGGL TCDHYEEAKI TCSAHREPRL 490 500 510 520 530 540 VGGDIPCSGR VEVKHGDTWG SICDSDFSLE AASVLCRELQ CGTVVSILGG AHFGEGNGQI 550 560 570 580 590 600 WAEEFQCEGH ESHLSLCPVA PRPEGTCSHS RDVGVVCSRY TEIRLVNGKT PCEGRVELKT 610 620 630 640 650 660 LGAWGSLCNS HWDIEDAHVL CQQLKCGVAL STPGGARFGK GNGQIWRHMF HCTGTEQHMG 670 680 690 700 710 720 DCPVTALGAS LCPSEQVASV ICSGNQSQTL SSCNSSSLGP TRPTIPEESA VACIESGQLR 730 740 750 760 770 780 LVNGGGRCAG RVEIYHEGSW GTICDDSWDL SDAHVVCRQL GCGEAINATG SAHFGEGTGP 790 800 810 820 830 840 IWLDEMKCNG KESRIWQCHS HGWGQQNCRH KEDAGVICSE FMSLRLTSEA SREACAGRLE 850 860 870 880 890 900 VFYNGAWGTV GKSSMSETTV GVVCRQLGCA DKGKINPASL DKAMSIPMWV DNVQCPKGPD 910 920 930 940 950 960 TLWQCPSSPW EKRLASPSEE TWITCDNKIR LQEGPTSCSG RVEIWHGGSW GTVCDDSWDL 970 980 990 1000 1010 1020 DDAQVVCQQL GCGPALKAFK EAEFGQGTGP IWLNEVKCKG NESSLWDCPA RRWGHSECGH 1030 1040 1050 1060 1070 1080 KEDAAVNCTD ISVQKTPQKA TTGRSSRQSS FIAVGILGVV LLAIFVALFF LTKKRRQRQR 1090 1100 1110 1120 LAVSSRGENL VHQIQYREMN SCLNADDLDL MNSSGGHSEP H
	Isoform 4 [UniParc]. Checksum: 8814E05FB2EDFE7B	FASTA	1,154	124,958
	10 20 30 40 50 60 MSKLRMVLLE DSGSADFRRH FVNLSPFTIT VVLLLSACFV TSSLGGTDKE LRLVDGENKC 70 80 90 100 110 120 SGRVEVKVQE EWGTVCNNGW SMEAVSVICN QLGCPTAIKA PGWANSSAGS GRIWMDHVSC 130 140 150 160 170 180 RGNESALWDC KHDGWGKHSN CTHQQDAGVT CSDGSNLEMR LTRGGNMCSG RIEIKFQGRW 190 200 210 220 230 240 GTVCDDNFNI DHASVICRQL ECGSAVSFSG SSNFGEGSGP IWFDDLICNG NESALWNCKH 250 260 270 280 290 300 QGWGKHNCDH AEDAGVICSK GADLSLRLVD GVTECSGRLE VRFQGEWGTI CDDGWDSYDA 310 320 330 340 350 360 AVACKQLGCP TAVTAIGRVN ASKGFGHIWL DSVSCQGHEP AIWQCKHHEW GKHYCNHNED 370 380 390 400 410 420 AGVTCSDGSD LELRLRGGGS RCAGTVEVEI QRLLGKVCDR GWGLKEADVV CRQLGCGSAL 430 440 450 460 470 480 KTSYQVYSKI QATNTWLFLS SCNGNETSLW DCKNWQWGGL TCDHYEEAKI TCSAHREPRL 490 500 510 520 530 540 VGGDIPCSGR VEVKHGDTWG SICDSDFSLE AASVLCRELQ CGTVVSILGG AHFGEGNGQI 550 560 570 580 590 600 WAEEFQCEGH ESHLSLCPVA PRPEGTCSHS RDVGVVCSSK TQKTSLIGSY TVKGTGLGSH 610 620 630 640 650 660 SCLFLKPCLL PGYTEIRLVN GKTPCEGRVE LKTLGAWGSL CNSHWDIEDA HVLCQQLKCG 670 680 690 700 710 720 VALSTPGGAR FGKGNGQIWR HMFHCTGTEQ HMGDCPVTAL GASLCPSEQV ASVICSGNQS 730 740 750 760 770 780 QTLSSCNSSS LGPTRPTIPE ESAVACIESG QLRLVNGGGR CAGRVEIYHE GSWGTICDDS 790 800 810 820 830 840 WDLSDAHVVC RQLGCGEAIN ATGSAHFGEG TGPIWLDEMK CNGKESRIWQ CHSHGWGQQN 850 860 870 880 890 900 CRHKEDAGVI CSEFMSLRLT SEASREACAG RLEVFYNGAW GTVGKSSMSE TTVGVVCRQL 910 920 930 940 950 960 GCADKGKINP ASLDKAMSIP MWVDNVQCPK GPDTLWQCPS SPWEKRLASP SEETWITCDN 970 980 990 1000 1010 1020 KIRLQEGPTS CSGRVEIWHG GSWGTVCDDS WDLDDAQVVC QQLGCGPALK AFKEAEFGQG 1030 1040 1050 1060 1070 1080 TGPIWLNEVK CKGNESSLWD CPARRWGHSE CGHKEDAAVN CTDISVQKTP QKATTGRSSR 1090 1100 1110 1120 1130 1140 QSSFIAVGIL GVVLLAIFVA LFFLTKKRRQ RQRLAVSSRG ENLVHQIQYR EMNSCLNADD 1150 LDLMNSSGGH SEPH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily." Law S.K.A., Micklem K.J., Shaw J.M., Zhang X.-P., Dong Y., Willis A.C., Mason D.Y. Eur. J. Immunol. 23:2320-2325(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT VAL-342.
[2]	"Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily." Ritter M., Buechler C., Langmann T., Schmitz G. Biochem. Biophys. Res. Commun. 260:466-474(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-342.
[3]	"Scavenger receptor cd163 is a cell permissive factor for infection with porcine reproductive and respiratory syndrome viruses." Welch S.-K.W., Calvert J.G., Slade D.E., Shields S.L. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT VAL-342.
[4]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-342. Tissue: Spleen.
[6]	"Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family." Droste A., Sorg C., Hogger P. Biochem. Biophys. Res. Commun. 256:110-113(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE.
[7]	"Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation." Van den Heuvel M.M., Tensen C.P., van As J.H., Van den Berg T.K., Fluitsma D.M., Dijkstra C.D., Dopp E.A., Droste A., Van Gaalen F.A., Sorg C., Hoegger P., Beelen R.H.J. J. Leukoc. Biol. 66:858-866(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION.
[8]	"Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli." Buechler C., Ritter M., Orso E., Langmann T., Klucken J., Schmitz G. J. Leukoc. Biol. 67:97-103(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, SUBCELLULAR LOCATION.
[9]	"Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C." Ritter M., Buechler C., Kapinsky M., Schmitz G. Eur. J. Immunol. 31:999-1009(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION, MUTAGENESIS OF THR-1072 AND SER-1084, INTERACTION WITH CSNK2B.
[10]	"Identification of the haemoglobin scavenger receptor." Kristiansen M., Graversen J.H., Jacobsen C., Sonne O., Hoffman H.-J., Law S.K.A., Moestrup S.K. Nature 409:198-201(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, MASS SPECTROMETRY.
[11]	"Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3." Matsushita N., Kashiwagi M., Wait R., Nagayoshi R., Nakamura M., Matsuda T., Hogger P., Guyre P.M., Nagase H., Matsuyama T. Clin. Exp. Immunol. 130:156-161(2002) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE.
[12]	"Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester-activated T-lymphocytes, whereas membrane-bound protein has no effect." Frings W., Dreier J., Sorg C. FEBS Lett. 526:93-96(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[13]	"Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163." Hintz K.A., Rassias A.J., Wardwell K., Moss M.L., Morganelli P.M., Pioli P.A., Givan A.L., Wallace P.K., Yeager M.P., Guyre P.M. J. Leukoc. Biol. 72:711-717(2002) [PubMed] [Europe PMC] [Abstract] Cited for: MISCELLANEOUS.
[14]	"CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response." Moestrup S.K., Moller H.J. Ann. Med. 36:347-354(2004) [PubMed] [Europe PMC] [Abstract] Cited for: RELEVANCE AS DISEASE MARKER IN INFLAMMATORY CONDITIONS.
[15]	"Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region." Madsen M., Moller H.J., Nielsen M.J., Jacobsen C., Graversen J.H., van den Berg T., Moestrup S.K. J. Biol. Chem. 279:51561-51567(2004) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN, CLEAVAGE SITES.
[16]	"Cross-linking of FcgammaR triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163." Sulahian T.H., Pioli P.A., Wardwell K., Guyre P.M. J. Leukoc. Biol. 76:271-277(2004) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE.
[17]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-105, MASS SPECTROMETRY. Tissue: Plasma.
[18]	"The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants." Nielsen M.J., Madsen M., Moller H.J., Moestrup S.K. J. Leukoc. Biol. 79:837-845(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF TYR-1096, TISSUE SPECIFICITY.
[19]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-105; ASN-140; ASN-767 AND ASN-1027, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z22968 mRNA. Translation: CAA80541.1. Different initiation. Z22969 mRNA. Translation: CAA80542.1. Different initiation. Z22970 mRNA. Translation: CAA80543.1. Different initiation. Z22971 mRNA. Translation: CAA80544.1. Different initiation. Y18388 , Y18389, Y18390, Y18391, Y18392, Y18393, Y18394, Y18395, Y18396, Y18397, Y18398, Y18399, Y18400, Y18401, Y18402, Y18403 Genomic DNA. Translation: CAB45233.1. Different initiation. DQ058615 mRNA. Translation: AAY99762.1. AC131206 Genomic DNA. No translation available. BC051281 mRNA. Translation: AAH51281.1.
IPI	IPI00104074. IPI00513892. IPI00759642. IPI00953368.
PIR	I38004. I38005. I38006.
RefSeq	NP_004235.4. NM_004244.5. NP_981961.2. NM_203416.3.
UniGene	Hs.504641.
3D structure databases
ProteinModelPortal	Q86VB7.
SMR	Q86VB7. Positions 48-264, 277-366, 373-473, 479-683, 714-824, 837-1030.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86VB7. 1 interaction.
STRING	9606.ENSP00000352071.
PTM databases
PhosphoSite	Q86VB7.
Proteomic databases
PaxDb	Q86VB7.
PRIDE	Q86VB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359156; ENSP00000352071; ENSG00000177575. ENST00000432237; ENSP00000403885; ENSG00000177575.
GeneID	9332.
KEGG	hsa:9332.
UCSC	uc001qsz.3. human. uc001qta.3. human.
Organism-specific databases
CTD	9332.
GeneCards	GC12M007623.
HGNC	HGNC:1631. CD163.
HPA	CAB002432.
MIM	605545. gene.
neXtProt	NX_Q86VB7.
PharmGKB	PA26190.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG83796.
HOVERGEN	HBG080943.
InParanoid	Q86VB7.
KO	K06545.
OMA	RFQGEWG.
OrthoDB	EOG4JWVD4.
PhylomeDB	Q86VB7.
Gene expression databases
ArrayExpress	Q86VB7.
Bgee	Q86VB7.
CleanEx	HS_CD163.
Genevestigator	Q86VB7.
GermOnline	ENSG00000177575. Homo sapiens.
Family and domain databases
InterPro	IPR001190. Srcr_rcpt. IPR017448. Srcr_rcpt-rel. [Graphical view]
Pfam	PF00530. SRCR. 9 hits. [Graphical view]
PRINTS	PR00258. SPERACTRCPTR.
SMART	SM00202. SR. 9 hits. [Graphical view]
SUPFAM	SSF56487. Srcr_receptor. 9 hits.
PROSITE	PS00420. SRCR_1. 4 hits. PS50287. SRCR_2. 9 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CD163. human.
GenomeRNAi	9332.
NextBio	34955.
SOURCE	Search...

Entry information

Entry name

C163A_HUMAN

Accession

Primary (citable) accession number: Q86VB7
Secondary accession number(s): C9JIG2 , Q07898, Q07899, Q07900, Q07901, Q2VLH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.