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Protein

Kelch repeat and BTB domain-containing protein 6

Gene

KBTBD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 6
Gene namesi
Name:KBTBD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:25340. KBTBD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165572.
PharmGKBiPA134955690.

Polymorphism and mutation databases

BioMutaiKBTBD6.
DMDMi45477125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190841 – 674Kelch repeat and BTB domain-containing protein 6Add BLAST674

Proteomic databases

EPDiQ86V97.
MaxQBiQ86V97.
PaxDbiQ86V97.
PeptideAtlasiQ86V97.
PRIDEiQ86V97.

PTM databases

iPTMnetiQ86V97.
PhosphoSitePlusiQ86V97.

Expressioni

Gene expression databases

BgeeiENSG00000165572.
CleanExiHS_KBTBD6.
GenevisibleiQ86V97. HS.

Organism-specific databases

HPAiHPA046861.
HPA048914.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951663EBI-2514778,EBI-712001
GABARAPL1Q9H0R84EBI-2514778,EBI-746969
GABARAPL2P605202EBI-2514778,EBI-720116
MAP1LC3BQ9GZQ82EBI-2514778,EBI-373144
MAP1LC3CQ9BXW42EBI-2514778,EBI-2603996

Protein-protein interaction databases

BioGridi124639. 44 interactors.
IntActiQ86V97. 10 interactors.
STRINGi9606.ENSP00000368799.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XC2X-ray1.90E/F/G/H663-673[»]
ProteinModelPortaliQ86V97.
SMRiQ86V97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 138BTBPROSITE-ProRule annotationAdd BLAST76
Repeati386 – 435Kelch 1Add BLAST50
Repeati436 – 484Kelch 2Add BLAST49
Repeati486 – 523Kelch 3Add BLAST38
Repeati524 – 564Kelch 4Add BLAST41
Repeati567 – 616Kelch 5Add BLAST50
Repeati642 – 673Kelch 6Add BLAST32

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiENOG410JAC8. Eukaryota.
ENOG4110S2H. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000074585.
HOVERGENiHBG052214.
InParanoidiQ86V97.
KOiK10474.
OMAiFISFDLM.
OrthoDBiEOG091G033H.
PhylomeDBiQ86V97.
TreeFamiTF332672.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86V97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSREDAPRS RRLASPRGGK RPKKIHKPTV SAFFTGPEEL KDTAHSAALL
60 70 80 90 100
AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFPCNRNVLA AACPYFKSMF
110 120 130 140 150
TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VERLYAASDM
160 170 180 190 200
LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFGHRKLRS QAQSYIAQNF
210 220 230 240 250
KQLSHMGSIR EETLADLTLA QLLAVLRLDS LDVESEQTVC HVAVQWLEAA
260 270 280 290 300
PKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
310 320 330 340 350
MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG
360 370 380 390 400
HPRDPFLCCD PYSGDLYKVP SPLTCLAHTR TVTTLAVCIS PDHDIYLAAQ
410 420 430 440 450
PRTDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK
460 470 480 490 500
LKEVECYNVK RNQWALVAPL PHSFLSFDLM VIRDYLYALN SKRMFCYDPS
510 520 530 540 550
HNMWLKCVSL KRNDFQEACV FNEEIYCICD IPVMKVYNPV RAEWRQMNNI
560 570 580 590 600
PLVSETNNYR IIKHGQKLLL ITSRTPQWKK NRVTVYEYDI RGDQWINIGT
610 620 630 640 650
TLGLLQFDSN FFCLSARVYP SCLEPGQSFL TEEEEIPSES STEWDLGGFS
660 670
EPDSESGSSS SLSDDDFWVR VAPQ
Length:674
Mass (Da):76,138
Last modified:June 1, 2003 - v1
Checksum:i5ED49AAEC6350CB5
GO

Sequence cautioni

The sequence BAC04826 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61L → Q in BAB71238 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056633 mRNA. Translation: BAB71238.1.
AK096608 mRNA. Translation: BAC04826.1. Different initiation.
AL354696 Genomic DNA. Translation: CAI16611.1.
BC000560 mRNA. Translation: AAH00560.1.
BC051349 mRNA. Translation: AAH51349.1.
AL833839 mRNA. Translation: CAD38699.1.
CCDSiCCDS9376.1.
RefSeqiNP_690867.3. NM_152903.4.
UniGeneiHs.534040.

Genome annotation databases

EnsembliENST00000379485; ENSP00000368799; ENSG00000165572.
GeneIDi89890.
KEGGihsa:89890.
UCSCiuc001uxu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056633 mRNA. Translation: BAB71238.1.
AK096608 mRNA. Translation: BAC04826.1. Different initiation.
AL354696 Genomic DNA. Translation: CAI16611.1.
BC000560 mRNA. Translation: AAH00560.1.
BC051349 mRNA. Translation: AAH51349.1.
AL833839 mRNA. Translation: CAD38699.1.
CCDSiCCDS9376.1.
RefSeqiNP_690867.3. NM_152903.4.
UniGeneiHs.534040.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XC2X-ray1.90E/F/G/H663-673[»]
ProteinModelPortaliQ86V97.
SMRiQ86V97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124639. 44 interactors.
IntActiQ86V97. 10 interactors.
STRINGi9606.ENSP00000368799.

PTM databases

iPTMnetiQ86V97.
PhosphoSitePlusiQ86V97.

Polymorphism and mutation databases

BioMutaiKBTBD6.
DMDMi45477125.

Proteomic databases

EPDiQ86V97.
MaxQBiQ86V97.
PaxDbiQ86V97.
PeptideAtlasiQ86V97.
PRIDEiQ86V97.

Protocols and materials databases

DNASUi89890.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379485; ENSP00000368799; ENSG00000165572.
GeneIDi89890.
KEGGihsa:89890.
UCSCiuc001uxu.2. human.

Organism-specific databases

CTDi89890.
GeneCardsiKBTBD6.
H-InvDBHIX0011264.
HGNCiHGNC:25340. KBTBD6.
HPAiHPA046861.
HPA048914.
neXtProtiNX_Q86V97.
OpenTargetsiENSG00000165572.
PharmGKBiPA134955690.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAC8. Eukaryota.
ENOG4110S2H. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000074585.
HOVERGENiHBG052214.
InParanoidiQ86V97.
KOiK10474.
OMAiFISFDLM.
OrthoDBiEOG091G033H.
PhylomeDBiQ86V97.
TreeFamiTF332672.

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii89890.
PROiQ86V97.

Gene expression databases

BgeeiENSG00000165572.
CleanExiHS_KBTBD6.
GenevisibleiQ86V97. HS.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKBTB6_HUMAN
AccessioniPrimary (citable) accession number: Q86V97
Secondary accession number(s): Q5T6Y8
, Q8N8L0, Q8NDM5, Q96MP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.