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Protein

Kelch repeat and BTB domain-containing protein 6

Gene

KBTBD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 6
Gene namesi
Name:KBTBD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:25340. KBTBD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134955690.

Polymorphism and mutation databases

BioMutaiKBTBD6.
DMDMi45477125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674Kelch repeat and BTB domain-containing protein 6PRO_0000119084Add
BLAST

Proteomic databases

EPDiQ86V97.
MaxQBiQ86V97.
PaxDbiQ86V97.
PRIDEiQ86V97.

PTM databases

iPTMnetiQ86V97.
PhosphoSiteiQ86V97.

Expressioni

Gene expression databases

BgeeiQ86V97.
CleanExiHS_KBTBD6.
GenevisibleiQ86V97. HS.

Organism-specific databases

HPAiHPA046861.
HPA048914.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951663EBI-2514778,EBI-712001
GABARAPL1Q9H0R84EBI-2514778,EBI-746969
GABARAPL2P605202EBI-2514778,EBI-720116
MAP1LC3BQ9GZQ82EBI-2514778,EBI-373144
MAP1LC3CQ9BXW42EBI-2514778,EBI-2603996

Protein-protein interaction databases

BioGridi124639. 44 interactions.
IntActiQ86V97. 10 interactions.
STRINGi9606.ENSP00000368799.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XC2X-ray1.90E/F/G/H663-673[»]
ProteinModelPortaliQ86V97.
SMRiQ86V97. Positions 42-289, 402-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 13876BTBPROSITE-ProRule annotationAdd
BLAST
Repeati386 – 43550Kelch 1Add
BLAST
Repeati436 – 48449Kelch 2Add
BLAST
Repeati486 – 52338Kelch 3Add
BLAST
Repeati524 – 56441Kelch 4Add
BLAST
Repeati567 – 61650Kelch 5Add
BLAST
Repeati642 – 67332Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiENOG410JAC8. Eukaryota.
ENOG4110S2H. LUCA.
GeneTreeiENSGT00840000129730.
HOGENOMiHOG000074585.
HOVERGENiHBG052214.
InParanoidiQ86V97.
KOiK10474.
OMAiFISFDLM.
OrthoDBiEOG7MSMNJ.
PhylomeDBiQ86V97.
TreeFamiTF332672.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86V97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSREDAPRS RRLASPRGGK RPKKIHKPTV SAFFTGPEEL KDTAHSAALL
60 70 80 90 100
AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFPCNRNVLA AACPYFKSMF
110 120 130 140 150
TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VERLYAASDM
160 170 180 190 200
LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFGHRKLRS QAQSYIAQNF
210 220 230 240 250
KQLSHMGSIR EETLADLTLA QLLAVLRLDS LDVESEQTVC HVAVQWLEAA
260 270 280 290 300
PKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
310 320 330 340 350
MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG
360 370 380 390 400
HPRDPFLCCD PYSGDLYKVP SPLTCLAHTR TVTTLAVCIS PDHDIYLAAQ
410 420 430 440 450
PRTDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK
460 470 480 490 500
LKEVECYNVK RNQWALVAPL PHSFLSFDLM VIRDYLYALN SKRMFCYDPS
510 520 530 540 550
HNMWLKCVSL KRNDFQEACV FNEEIYCICD IPVMKVYNPV RAEWRQMNNI
560 570 580 590 600
PLVSETNNYR IIKHGQKLLL ITSRTPQWKK NRVTVYEYDI RGDQWINIGT
610 620 630 640 650
TLGLLQFDSN FFCLSARVYP SCLEPGQSFL TEEEEIPSES STEWDLGGFS
660 670
EPDSESGSSS SLSDDDFWVR VAPQ
Length:674
Mass (Da):76,138
Last modified:June 1, 2003 - v1
Checksum:i5ED49AAEC6350CB5
GO

Sequence cautioni

The sequence BAC04826.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611L → Q in BAB71238 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056633 mRNA. Translation: BAB71238.1.
AK096608 mRNA. Translation: BAC04826.1. Different initiation.
AL354696 Genomic DNA. Translation: CAI16611.1.
BC000560 mRNA. Translation: AAH00560.1.
BC051349 mRNA. Translation: AAH51349.1.
AL833839 mRNA. Translation: CAD38699.1.
CCDSiCCDS9376.1.
RefSeqiNP_690867.3. NM_152903.4.
UniGeneiHs.534040.

Genome annotation databases

EnsembliENST00000379485; ENSP00000368799; ENSG00000165572.
GeneIDi89890.
KEGGihsa:89890.
UCSCiuc001uxu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056633 mRNA. Translation: BAB71238.1.
AK096608 mRNA. Translation: BAC04826.1. Different initiation.
AL354696 Genomic DNA. Translation: CAI16611.1.
BC000560 mRNA. Translation: AAH00560.1.
BC051349 mRNA. Translation: AAH51349.1.
AL833839 mRNA. Translation: CAD38699.1.
CCDSiCCDS9376.1.
RefSeqiNP_690867.3. NM_152903.4.
UniGeneiHs.534040.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XC2X-ray1.90E/F/G/H663-673[»]
ProteinModelPortaliQ86V97.
SMRiQ86V97. Positions 42-289, 402-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124639. 44 interactions.
IntActiQ86V97. 10 interactions.
STRINGi9606.ENSP00000368799.

PTM databases

iPTMnetiQ86V97.
PhosphoSiteiQ86V97.

Polymorphism and mutation databases

BioMutaiKBTBD6.
DMDMi45477125.

Proteomic databases

EPDiQ86V97.
MaxQBiQ86V97.
PaxDbiQ86V97.
PRIDEiQ86V97.

Protocols and materials databases

DNASUi89890.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379485; ENSP00000368799; ENSG00000165572.
GeneIDi89890.
KEGGihsa:89890.
UCSCiuc001uxu.2. human.

Organism-specific databases

CTDi89890.
GeneCardsiKBTBD6.
H-InvDBHIX0011264.
HGNCiHGNC:25340. KBTBD6.
HPAiHPA046861.
HPA048914.
neXtProtiNX_Q86V97.
PharmGKBiPA134955690.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAC8. Eukaryota.
ENOG4110S2H. LUCA.
GeneTreeiENSGT00840000129730.
HOGENOMiHOG000074585.
HOVERGENiHBG052214.
InParanoidiQ86V97.
KOiK10474.
OMAiFISFDLM.
OrthoDBiEOG7MSMNJ.
PhylomeDBiQ86V97.
TreeFamiTF332672.

Miscellaneous databases

GenomeRNAii89890.
NextBioi76417.
PROiQ86V97.

Gene expression databases

BgeeiQ86V97.
CleanExiHS_KBTBD6.
GenevisibleiQ86V97. HS.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Prostate.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-674.
    Tissue: Brain.

Entry informationi

Entry nameiKBTB6_HUMAN
AccessioniPrimary (citable) accession number: Q86V97
Secondary accession number(s): Q5T6Y8
, Q8N8L0, Q8NDM5, Q96MP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.