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Protein

Protein FAM160B2

Gene

FAM160B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM160B2
Alternative name(s):
Retinoic acid-induced protein 16
Gene namesi
Name:FAM160B2
Synonyms:RAI16
ORF Names:FP13191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:16492. FAM160B2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158863.
PharmGKBiPA162386837.

Polymorphism and mutation databases

BioMutaiFAM160B2.
DMDMi145566932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846451 – 743Protein FAM160B2Add BLAST743

Proteomic databases

EPDiQ86V87.
MaxQBiQ86V87.
PaxDbiQ86V87.
PeptideAtlasiQ86V87.
PRIDEiQ86V87.

PTM databases

iPTMnetiQ86V87.
PhosphoSitePlusiQ86V87.

Expressioni

Gene expression databases

BgeeiENSG00000158863.
CleanExiHS_FAM160B2.
ExpressionAtlasiQ86V87. baseline and differential.
GenevisibleiQ86V87. HS.

Organism-specific databases

HPAiHPA025040.

Interactioni

Protein-protein interaction databases

BioGridi122273. 7 interactors.
IntActiQ86V87. 1 interactor.
STRINGi9606.ENSP00000289921.

Structurei

3D structure databases

ProteinModelPortaliQ86V87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0518 family.Curated

Phylogenomic databases

eggNOGiENOG410IN31. Eukaryota.
ENOG410XTDG. LUCA.
GeneTreeiENSGT00760000119270.
HOVERGENiHBG107875.
InParanoidiQ86V87.
OMAiEHWKGIT.
OrthoDBiEOG091G04PO.
PhylomeDBiQ86V87.
TreeFamiTF313941.

Family and domain databases

InterProiIPR019384. RetinoicA-induced_16-like.
[Graphical view]
PfamiPF10257. RAI16-like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86V87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRLGALLQ EAVGAREPSI DLLQAFVEHW KGITHYYIES TDESTPAKKT
60 70 80 90 100
DIPWRLKQML DILVYEEQQQ AAAGEAGPCL EYLLQHKILE TLCTLGKAEY
110 120 130 140 150
PPGMRQQVFQ FFSKVLAQVQ HPLLHYLSVH RPVQKLLRLG GTASGSVTEK
160 170 180 190 200
EEVQFTTVLC SKIQQDPELL AYILEGKKIV GRKKACGEPT ALPKDTTSHG
210 220 230 240 250
DKDCSHDGAP ARPQLDGESC GAQALNSHMP AETEELDGGT TESNLITSLL
260 270 280 290 300
GLCQSKKSRV ALKAQENLLL LVSMASPAAA TYLVQSSACC PAIVRHLCQL
310 320 330 340 350
YRSMPVFLDP ADIATLEGIS WRLPSAPSDE ASFPGKEALA AFLGWFDYCD
360 370 380 390 400
HLITEAHTVV ADALAKAVAE NFFVETLQPQ LLHVSEQSIL TSTALLTAML
410 420 430 440 450
RQLRSPALLR EAVAFLLGTD RQPEAPGDNP HTLYAHLIGH CDHLSDEISI
460 470 480 490 500
TTLRLFEELL QKPHEGIIHS LVLRNLEGRP YVAWGSPEPE SYEDTLDLEE
510 520 530 540 550
DPYFTDSFLD SGFQTPAKPR LAPATSYDGK TAVTEIVNSF LCLVPEEAKT
560 570 580 590 600
SAFLEETGYD TYVHDAYGLF QECSSRVASW GWPLTPTPLD PHEPERPFFE
610 620 630 640 650
GHFLRVLFDR MSRILDQPYS LNLQVTSVLS RLALFPHPHI HEYLLDPYIS
660 670 680 690 700
LAPGCRSLFS VLVRVIGDLM QRIQRVPQFP GKLLLVRKQL TGQAPGEQLD
710 720 730 740
HQTLLQGVVV LEEFCKELAA IAFVKFPPHD PRQNVSPAPE GQV
Length:743
Mass (Da):82,340
Last modified:April 17, 2007 - v2
Checksum:i3AD149894AB08CF5
GO

Sequence cautioni

The sequence AAH52237 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI12148 differs from that shown. Reason: Frameshift at position 291.Curated
The sequence AAI12148 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAQ06676 differs from that shown. Reason: Frameshift at positions 258 and 727.Curated
The sequence BAB15137 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG38002 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG51483 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182R → G in AAQ06676 (PubMed:15498874).Curated1
Sequence conflicti684L → F in AAH12865 (PubMed:15489334).Curated1
Sequence conflicti684L → F in AAH13350 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054008315T → A.2 PublicationsCorresponds to variant rs35497596dbSNPEnsembl.1
Natural variantiVAR_054009667G → R.Corresponds to variant rs7822461dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091171 Genomic DNA. No translation available.
BC012865 mRNA. Translation: AAH12865.3.
BC013350 mRNA. Translation: AAH13350.2.
BC052237 mRNA. Translation: AAH52237.1. Different initiation.
BC112147 mRNA. Translation: AAI12148.2. Sequence problems.
AF495722 mRNA. Translation: AAQ06676.1. Frameshift.
AK025454 mRNA. Translation: BAB15137.1. Different initiation.
AK315634 mRNA. Translation: BAG38002.1. Different initiation.
AK055191 mRNA. Translation: BAG51483.1. Different initiation.
CCDSiCCDS6021.2.
RefSeqiNP_073586.5. NM_022749.5.
UniGeneiHs.491223.

Genome annotation databases

EnsembliENST00000289921; ENSP00000289921; ENSG00000158863.
ENST00000450006; ENSP00000403288; ENSG00000158863.
GeneIDi64760.
KEGGihsa:64760.
UCSCiuc011kyx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091171 Genomic DNA. No translation available.
BC012865 mRNA. Translation: AAH12865.3.
BC013350 mRNA. Translation: AAH13350.2.
BC052237 mRNA. Translation: AAH52237.1. Different initiation.
BC112147 mRNA. Translation: AAI12148.2. Sequence problems.
AF495722 mRNA. Translation: AAQ06676.1. Frameshift.
AK025454 mRNA. Translation: BAB15137.1. Different initiation.
AK315634 mRNA. Translation: BAG38002.1. Different initiation.
AK055191 mRNA. Translation: BAG51483.1. Different initiation.
CCDSiCCDS6021.2.
RefSeqiNP_073586.5. NM_022749.5.
UniGeneiHs.491223.

3D structure databases

ProteinModelPortaliQ86V87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122273. 7 interactors.
IntActiQ86V87. 1 interactor.
STRINGi9606.ENSP00000289921.

PTM databases

iPTMnetiQ86V87.
PhosphoSitePlusiQ86V87.

Polymorphism and mutation databases

BioMutaiFAM160B2.
DMDMi145566932.

Proteomic databases

EPDiQ86V87.
MaxQBiQ86V87.
PaxDbiQ86V87.
PeptideAtlasiQ86V87.
PRIDEiQ86V87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289921; ENSP00000289921; ENSG00000158863.
ENST00000450006; ENSP00000403288; ENSG00000158863.
GeneIDi64760.
KEGGihsa:64760.
UCSCiuc011kyx.3. human.

Organism-specific databases

CTDi64760.
GeneCardsiFAM160B2.
HGNCiHGNC:16492. FAM160B2.
HPAiHPA025040.
neXtProtiNX_Q86V87.
OpenTargetsiENSG00000158863.
PharmGKBiPA162386837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN31. Eukaryota.
ENOG410XTDG. LUCA.
GeneTreeiENSGT00760000119270.
HOVERGENiHBG107875.
InParanoidiQ86V87.
OMAiEHWKGIT.
OrthoDBiEOG091G04PO.
PhylomeDBiQ86V87.
TreeFamiTF313941.

Miscellaneous databases

GenomeRNAii64760.
PROiQ86V87.

Gene expression databases

BgeeiENSG00000158863.
CleanExiHS_FAM160B2.
ExpressionAtlasiQ86V87. baseline and differential.
GenevisibleiQ86V87. HS.

Family and domain databases

InterProiIPR019384. RetinoicA-induced_16-like.
[Graphical view]
PfamiPF10257. RAI16-like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF16B2_HUMAN
AccessioniPrimary (citable) accession number: Q86V87
Secondary accession number(s): B2RDQ5
, B3KNX1, Q2M211, Q71JB5, Q7L3J6, Q969T0, Q9H6W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.