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UniProtKB - Q86V86 (PIM3_HUMAN)

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Protein

Serine/threonine-protein kinase pim-3

Gene

PIM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.5 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69ATPPROSITE-ProRule annotation1
Active sitei170Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 54ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cell cycle Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  • protein autophosphorylation Source: GO_Central
  • protein phosphorylation Source: UniProtKB
  • regulation of mitotic cell cycle Source: UniProtKB
Complete GO annotation...

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Cell cycle
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ86V86.
SIGNORiQ86V86.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase pim-3 (EC:2.7.11.1)
Gene namesi
Name:PIM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:19310. PIM3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi415116.
OpenTargetsiENSG00000198355.
PharmGKBiPA134980758.

Chemistry databases

ChEMBLiCHEMBL5407.
GuidetoPHARMACOLOGYi2160.

Polymorphism and mutation databases

BioMutaiPIM3.
DMDMi215274221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865331 – 326Serine/threonine-protein kinase pim-3Add BLAST326

Post-translational modificationi

Ubiquitinated, leading to proteasomal degradation.1 Publication
Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ86V86.
PaxDbiQ86V86.
PeptideAtlasiQ86V86.
PRIDEiQ86V86.

PTM databases

iPTMnetiQ86V86.
PhosphoSitePlusiQ86V86.

Expressioni

Tissue specificityi

Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs.3 Publications

Gene expression databases

BgeeiENSG00000198355.
CleanExiHS_PIM3.
GenevisibleiQ86V86. HS.

Organism-specific databases

HPAiHPA068758.

Interactioni

Subunit structurei

Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM3, ubiquitination and proteasomal degradation. Interacts with SOCS6 (By similarity).By similarity

Protein-protein interaction databases

BioGridi136104. 1 interactor.
IntActiQ86V86. 2 interactors.
MINTiMINT-6823599.
STRINGi9606.ENSP00000353824.

Chemistry databases

BindingDBiQ86V86.

Structurei

3D structure databases

ProteinModelPortaliQ86V86.
SMRiQ86V86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 293Protein kinasePROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.Curated

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000119045.
HOGENOMiHOG000231357.
HOVERGENiHBG106681.
InParanoidiQ86V86.
KOiK08807.
OMAiMDHLPVK.
OrthoDBiEOG091G0IMW.
PhylomeDBiQ86V86.
TreeFamiTF320810.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR017348. PIM1/2/3.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
PIRSFiPIRSF037993. STPK_Pim-1. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86V86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSKFGSLA HLCGPGGVDH LPVKILQPAK ADKESFEKAY QVGAVLGSGG 
        60         70         80         90        100
FGTVYAGSRI ADGLPVAVKH VVKERVTEWG SLGGATVPLE VVLLRKVGAA 
       110        120        130        140        150
GGARGVIRLL DWFERPDGFL LVLERPEPAQ DLFDFITERG ALDEPLARRF 
       160        170        180        190        200
FAQVLAAVRH CHSCGVVHRD IKDENLLVDL RSGELKLIDF GSGALLKDTV 
       210        220        230        240        250
YTDFDGTRVY SPPEWIRYHR YHGRSATVWS LGVLLYDMVC GDIPFEQDEE 
       260        270        280        290        300
ILRGRLLFRR RVSPECQQLI RWCLSLRPSE RPSLDQIAAH PWMLGADGGV 
       310        320 
PESCDLRLCT LDPDDVASTT SSSESL
Length:326
Mass (Da):35,891
Last modified:November 25, 2008 - v3
Checksum:i41FDEFAC4367A162
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37E → K in AAI41856 (PubMed:15489334).Curated1
Sequence conflicti300V → A in BAD42438 (PubMed:15540201).Curated1
Sequence conflicti300V → A in BAF84694 (PubMed:16141072).Curated1
Sequence conflicti300V → A in AAI41856 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB114795 mRNA. Translation: BAD42438.1.
AK292005 mRNA. Translation: BAF84694.1.
CR536608, BX539320 Genomic DNA. Translation: CAO03523.1.
BX539320, CR536608 Genomic DNA. Translation: CAO03581.1.
BC052239 mRNA. No translation available.
BC141855 mRNA. Translation: AAI41856.1.
CCDSiCCDS33678.1.
RefSeqiNP_001001852.2. NM_001001852.3.
UniGeneiHs.530381.

Genome annotation databases

EnsembliENST00000360612; ENSP00000353824; ENSG00000198355.
GeneIDi415116.
KEGGihsa:415116.
UCSCiuc003bjb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB114795 mRNA. Translation: BAD42438.1.
AK292005 mRNA. Translation: BAF84694.1.
CR536608, BX539320 Genomic DNA. Translation: CAO03523.1.
BX539320, CR536608 Genomic DNA. Translation: CAO03581.1.
BC052239 mRNA. No translation available.
BC141855 mRNA. Translation: AAI41856.1.
CCDSiCCDS33678.1.
RefSeqiNP_001001852.2. NM_001001852.3.
UniGeneiHs.530381.

3D structure databases

ProteinModelPortaliQ86V86.
SMRiQ86V86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136104. 1 interactor.
IntActiQ86V86. 2 interactors.
MINTiMINT-6823599.
STRINGi9606.ENSP00000353824.

Chemistry databases

BindingDBiQ86V86.
ChEMBLiCHEMBL5407.
GuidetoPHARMACOLOGYi2160.

PTM databases

iPTMnetiQ86V86.
PhosphoSitePlusiQ86V86.

Polymorphism and mutation databases

BioMutaiPIM3.
DMDMi215274221.

Proteomic databases

MaxQBiQ86V86.
PaxDbiQ86V86.
PeptideAtlasiQ86V86.
PRIDEiQ86V86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360612; ENSP00000353824; ENSG00000198355.
GeneIDi415116.
KEGGihsa:415116.
UCSCiuc003bjb.4. human.

Organism-specific databases

CTDi415116.
DisGeNETi415116.
GeneCardsiPIM3.
H-InvDBiHIX0203204.
HGNCiHGNC:19310. PIM3.
HPAiHPA068758.
MIMi610580. gene.
neXtProtiNX_Q86V86.
OpenTargetsiENSG00000198355.
PharmGKBiPA134980758.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000119045.
HOGENOMiHOG000231357.
HOVERGENiHBG106681.
InParanoidiQ86V86.
KOiK08807.
OMAiMDHLPVK.
OrthoDBiEOG091G0IMW.
PhylomeDBiQ86V86.
TreeFamiTF320810.

Enzyme and pathway databases

SignaLinkiQ86V86.
SIGNORiQ86V86.

Miscellaneous databases

ChiTaRSiPIM3. human.
GenomeRNAii415116.
PROiPR:Q86V86.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198355.
CleanExiHS_PIM3.
GenevisibleiQ86V86. HS.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR017348. PIM1/2/3.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
PIRSFiPIRSF037993. STPK_Pim-1. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPIM3_HUMAN
AccessioniPrimary (citable) accession number: Q86V86
Secondary accession number(s): A5D8X8
, A8K7J0, B1B0P0, Q68BM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 25, 2008
Last modified: June 7, 2017
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.