UniProtKB - Q86V86 (PIM3_HUMAN)
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Protein
Serine/threonine-protein kinase pim-3
Gene
PIM3
Organism
Homo sapiens (Human)
Status
Functioni
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.5 Publications
Catalytic activityi
ATP + a protein = ADP + a phosphoprotein.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 69 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 170 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 46 – 54 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
- protein autophosphorylation Source: GO_Central
- protein phosphorylation Source: UniProtKB
- regulation of mitotic cell cycle Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Cell cycle |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | Q86V86. |
SIGNORi | Q86V86. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PIM3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198355.4. |
HGNCi | HGNC:19310. PIM3. |
MIMi | 610580. gene. |
neXtProti | NX_Q86V86. |
Pathology & Biotechi
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 415116. |
OpenTargetsi | ENSG00000198355. |
PharmGKBi | PA134980758. |
Chemistry databases
ChEMBLi | CHEMBL5407. |
GuidetoPHARMACOLOGYi | 2160. |
Polymorphism and mutation databases
BioMutai | PIM3. |
DMDMi | 215274221. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086533 | 1 – 326 | Serine/threonine-protein kinase pim-3Add BLAST | 326 |
Post-translational modificationi
Ubiquitinated, leading to proteasomal degradation.1 Publication
Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q86V86. |
MaxQBi | Q86V86. |
PaxDbi | Q86V86. |
PeptideAtlasi | Q86V86. |
PRIDEi | Q86V86. |
PTM databases
iPTMneti | Q86V86. |
PhosphoSitePlusi | Q86V86. |
Expressioni
Tissue specificityi
Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs.3 Publications
Gene expression databases
Bgeei | ENSG00000198355. |
CleanExi | HS_PIM3. |
Genevisiblei | Q86V86. HS. |
Organism-specific databases
HPAi | HPA068758. |
Interactioni
Subunit structurei
Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM3, ubiquitination and proteasomal degradation. Interacts with SOCS6 (By similarity).By similarity
Protein-protein interaction databases
BioGridi | 136104. 1 interactor. |
IntActi | Q86V86. 2 interactors. |
MINTi | Q86V86. |
STRINGi | 9606.ENSP00000353824. |
Chemistry databases
BindingDBi | Q86V86. |
Structurei
3D structure databases
ProteinModelPortali | Q86V86. |
SMRi | Q86V86. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 293 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 254 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0583. Eukaryota. COG0515. LUCA. |
GeneTreei | ENSGT00760000119045. |
HOGENOMi | HOG000231357. |
HOVERGENi | HBG106681. |
InParanoidi | Q86V86. |
KOi | K08807. |
OMAi | MDHLPVK. |
OrthoDBi | EOG091G0IMW. |
PhylomeDBi | Q86V86. |
TreeFami | TF320810. |
Family and domain databases
InterProi | View protein in InterPro IPR011009. Kinase-like_dom_sf. IPR017348. PIM1/2/3. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. |
Pfami | View protein in Pfam PF00069. Pkinase. 1 hit. |
PIRSFi | PIRSF037993. STPK_Pim-1. 1 hit. |
SMARTi | View protein in SMART SM00220. S_TKc. 1 hit. |
SUPFAMi | SSF56112. SSF56112. 1 hit. |
PROSITEi | View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q86V86-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLSKFGSLA HLCGPGGVDH LPVKILQPAK ADKESFEKAY QVGAVLGSGG
60 70 80 90 100
FGTVYAGSRI ADGLPVAVKH VVKERVTEWG SLGGATVPLE VVLLRKVGAA
110 120 130 140 150
GGARGVIRLL DWFERPDGFL LVLERPEPAQ DLFDFITERG ALDEPLARRF
160 170 180 190 200
FAQVLAAVRH CHSCGVVHRD IKDENLLVDL RSGELKLIDF GSGALLKDTV
210 220 230 240 250
YTDFDGTRVY SPPEWIRYHR YHGRSATVWS LGVLLYDMVC GDIPFEQDEE
260 270 280 290 300
ILRGRLLFRR RVSPECQQLI RWCLSLRPSE RPSLDQIAAH PWMLGADGGV
310 320
PESCDLRLCT LDPDDVASTT SSSESL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | E → K in AAI41856 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 300 | V → A in BAD42438 (PubMed:15540201).Curated | 1 | |
Sequence conflicti | 300 | V → A in BAF84694 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 300 | V → A in AAI41856 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB114795 mRNA. Translation: BAD42438.1. AK292005 mRNA. Translation: BAF84694.1. CR536608 Genomic DNA. No translation available. BX539320 Genomic DNA. No translation available. BC052239 mRNA. No translation available. BC141855 mRNA. Translation: AAI41856.1. |
CCDSi | CCDS33678.1. |
RefSeqi | NP_001001852.2. NM_001001852.3. |
UniGenei | Hs.530381. |
Genome annotation databases
Ensembli | ENST00000360612; ENSP00000353824; ENSG00000198355. |
GeneIDi | 415116. |
KEGGi | hsa:415116. |
UCSCi | uc003bjb.4. human. |
Similar proteinsi
Entry informationi
Entry namei | PIM3_HUMAN | |
Accessioni | Q86V86Primary (citable) accession number: Q86V86 Secondary accession number(s): A5D8X8 Q68BM2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 21, 2003 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 28, 2018 | |
This is version 135 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |