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Protein

Integral membrane protein GPR180

Gene

GPR180

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein GPR180
Alternative name(s):
Intimal thickness-related receptor
Gene namesi
Name:GPR180
Synonyms:ITR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:28899. GPR180.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence analysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Transmembranei284 – 30421HelicalSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Transmembranei360 – 38021HelicalSequence analysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596429.

Polymorphism and mutation databases

BioMutaiGPR180.
DMDMi74750449.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 440418Integral membrane protein GPR180PRO_0000239662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ86V85.
MaxQBiQ86V85.
PaxDbiQ86V85.
PRIDEiQ86V85.

Expressioni

Gene expression databases

BgeeiQ86V85.
CleanExiHS_GPR180.
GenevisibleiQ86V85. HS.

Organism-specific databases

HPAiHPA047250.

Interactioni

Protein-protein interaction databases

BioGridi127770. 4 interactions.
IntActiQ86V85. 1 interaction.
STRINGi9606.ENSP00000366157.

Structurei

3D structure databases

ProteinModelPortaliQ86V85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4290. Eukaryota.
ENOG410XRGS. LUCA.
GeneTreeiENSGT00730000111205.
HOGENOMiHOG000013021.
HOVERGENiHBG056171.
InParanoidiQ86V85.
OMAiPGLACIS.
OrthoDBiEOG793B7H.
PhylomeDBiQ86V85.
TreeFamiTF314975.

Family and domain databases

InterProiIPR019336. Intimal_thickness-rel_rcpt.
[Graphical view]
PfamiPF10192. GpcrRhopsn4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86V85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLRLLAVA LTCCWWPQGS QGKTLRGSFS STAAQDAQGQ RIGHFEFHGD
60 70 80 90 100
HALLCVRINN IAVAVGKEAK LYLFQAQEWL KLQQSSHGYS CSEKLSKAQL
110 120 130 140 150
TMTMNQTEHN LTVSQIPSPQ TWHVFYADKY TCQDDKENSQ VEDIPFEMVL
160 170 180 190 200
LNPDAEGNPF DHFSAGESGL HEFFFLLVLV YFVIACIYAQ SLWQAIKKGG
210 220 230 240 250
PMHMILKVLT TALLLQAGSA LANYIHFSSY SKDGIGVPFM GSLAEFFDIA
260 270 280 290 300
SQIQMLYLLL SLCMGWTIVR MKKSQSRPLQ WDSTPASTGI AVFIVMTQSV
310 320 330 340 350
LLLWEQFEDI SHHSYHSHHN LAGILLIVLR ICLALSLGCG LYQIITVERS
360 370 380 390 400
TLKREFYITF AKGCILWFLC HPVLACISVI FSDYQRDKVI TIGVILCQSV
410 420 430 440
SMVILYRLFL SHSLYWEVSS LSSVTLPLTI SSGHKSRPHF
Length:440
Mass (Da):49,395
Last modified:June 1, 2003 - v1
Checksum:iCC703269832CF8A3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321T → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_035925

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289850 mRNA. Translation: BAF82539.1.
AL359708 Genomic DNA. Translation: CAI12412.1.
CH471085 Genomic DNA. Translation: EAX08944.1.
BC052243 mRNA. Translation: AAH52243.1.
CCDSiCCDS9472.1.
RefSeqiNP_851320.1. NM_180989.5.
UniGeneiHs.439363.

Genome annotation databases

EnsembliENST00000376958; ENSP00000366157; ENSG00000152749.
GeneIDi160897.
KEGGihsa:160897.
UCSCiuc001vly.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289850 mRNA. Translation: BAF82539.1.
AL359708 Genomic DNA. Translation: CAI12412.1.
CH471085 Genomic DNA. Translation: EAX08944.1.
BC052243 mRNA. Translation: AAH52243.1.
CCDSiCCDS9472.1.
RefSeqiNP_851320.1. NM_180989.5.
UniGeneiHs.439363.

3D structure databases

ProteinModelPortaliQ86V85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127770. 4 interactions.
IntActiQ86V85. 1 interaction.
STRINGi9606.ENSP00000366157.

Polymorphism and mutation databases

BioMutaiGPR180.
DMDMi74750449.

Proteomic databases

EPDiQ86V85.
MaxQBiQ86V85.
PaxDbiQ86V85.
PRIDEiQ86V85.

Protocols and materials databases

DNASUi160897.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376958; ENSP00000366157; ENSG00000152749.
GeneIDi160897.
KEGGihsa:160897.
UCSCiuc001vly.4. human.

Organism-specific databases

CTDi160897.
GeneCardsiGPR180.
HGNCiHGNC:28899. GPR180.
HPAiHPA047250.
MIMi607787. gene.
neXtProtiNX_Q86V85.
PharmGKBiPA144596429.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4290. Eukaryota.
ENOG410XRGS. LUCA.
GeneTreeiENSGT00730000111205.
HOGENOMiHOG000013021.
HOVERGENiHBG056171.
InParanoidiQ86V85.
OMAiPGLACIS.
OrthoDBiEOG793B7H.
PhylomeDBiQ86V85.
TreeFamiTF314975.

Miscellaneous databases

GenomeRNAii160897.
PROiQ86V85.
SOURCEiSearch...

Gene expression databases

BgeeiQ86V85.
CleanExiHS_GPR180.
GenevisibleiQ86V85. HS.

Family and domain databases

InterProiIPR019336. Intimal_thickness-rel_rcpt.
[Graphical view]
PfamiPF10192. GpcrRhopsn4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  5. "High-density SNP map of human ITR, a gene associated with vascular remodeling."
    Iida A., Tanaka T., Nakamura Y.
    J. Hum. Genet. 48:170-172(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE ORGANIZATION.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-32.

Entry informationi

Entry nameiGP180_HUMAN
AccessioniPrimary (citable) accession number: Q86V85
Secondary accession number(s): A8K1D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.