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Protein

Zinc finger protein 429

Gene

ZNF429

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 429
Gene namesi
Name:ZNF429
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20817. ZNF429.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910790.

Polymorphism and mutation databases

BioMutaiZNF429.
DMDMi218511972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674Zinc finger protein 429PRO_0000047577Add
BLAST

Proteomic databases

EPDiQ86V71.
PaxDbiQ86V71.
PeptideAtlasiQ86V71.
PRIDEiQ86V71.

PTM databases

iPTMnetiQ86V71.
PhosphoSiteiQ86V71.

Expressioni

Gene expression databases

BgeeiENSG00000197013.
CleanExiHS_ZNF429.
ExpressionAtlasiQ86V71. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351280.

Structurei

3D structure databases

ProteinModelPortaliQ86V71.
SMRiQ86V71. Positions 143-646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86V71.
KOiK09228.
OMAiIRENTYR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86V71.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86V71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLTFTDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEKEK EPCKMKRHEM VDEPPVVCSH FAEDFWPEQD IKDSFQKVTL
110 120 130 140 150
RRYDKRGHEN LQLRKGYKTV GDCKLYKGGY NGLNQCLTLT QSKMYHCDIY
160 170 180 190 200
VKVFYAFSNA DRYKTRHTGK KPFQCKKCGK SFCMLSQLTQ HKKIHIRENT
210 220 230 240 250
YRCKEFGNAF NQSSALTNHK RIYVGEKHYR CEECGKAFNH YSTLTNHKRI
260 270 280 290 300
HTGEKPYKCK ECGKAFSRYS TLTTHKRIHS GEKPYKCDEC GKTFSISSTF
310 320 330 340 350
TKHKIIHTEE KPYKCKECGK AFNRSSTLTS HKRIHTGEKP YKCEECGKAF
360 370 380 390 400
NWSSTLTKHK VIHTGEKPYK CEECGKAFNQ SSRLTRHKKI HTGEEPYKFE
410 420 430 440 450
KCGRVFTCSS TLTQDKKIHT GEKPYNCEEC GKVFTYSSTL TRHKRIHTEE
460 470 480 490 500
KPYKCNECGK AFNRSSHLTS HRRIHTGEKP YKCEECGKAF KQSSNLNSHK
510 520 530 540 550
KIHSGEKPYK CEECGKAFIL SSRLTQHKKI HTGEKPYKCE ECGKAFNRSS
560 570 580 590 600
RLTQHKKIHT GEKPYKCKQC DKAFTHSSNL SSHKKIHSGE KPYKCEECGK
610 620 630 640 650
AFNRSSRLTQ HKKIHTREKP YKCEECAKAF TRSSRLTQHK KIHRMGVVAH
660 670
ACNPSTLGGR GGRITRSGDR DRPG
Length:674
Mass (Da):78,152
Last modified:December 16, 2008 - v2
Checksum:iC48BC76B58059FE7
GO

Sequence cautioni

The sequence AAK01422 differs from that shown.Curated
The sequence AAK01422 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AAP30884 differs from that shown.Curated
The sequence AAP30884 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671H → Y in AAP30884 (Ref. 2) Curated
Sequence conflicti167 – 1671H → Y in AAK01422 (PubMed:7865130).Curated
Sequence conflicti206 – 2072FG → CC in AAP30884 (Ref. 2) Curated
Sequence conflicti206 – 2072FG → CC in AAK01422 (PubMed:7865130).Curated
Sequence conflicti249 – 27628Missing in AAP30884 (Ref. 2) CuratedAdd
BLAST
Sequence conflicti249 – 27628Missing in AAK01422 (PubMed:7865130).CuratedAdd
BLAST
Sequence conflicti252 – 2521T → S in AAP30884 (Ref. 2) Curated
Sequence conflicti252 – 2521T → S in AAK01422 (PubMed:7865130).Curated
Sequence conflicti337 – 3371G → V in AAP30884 (Ref. 2) Curated
Sequence conflicti337 – 3371G → V in AAK01422 (PubMed:7865130).Curated
Sequence conflicti361 – 3611V → I in AAP30884 (Ref. 2) Curated
Sequence conflicti361 – 3611V → I in AAK01422 (PubMed:7865130).Curated
Sequence conflicti367 – 3671K → N in AAK01422 (PubMed:7865130).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti650 – 6501H → Y.
Corresponds to variant rs2562473 [ dbSNP | Ensembl ].
VAR_047848

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010615 Genomic DNA. No translation available.
AY269786 mRNA. Translation: AAP30884.1. Sequence problems.
AF325191 mRNA. Translation: AAK01422.1. Sequence problems.
BM996292 mRNA. No translation available.
CCDSiCCDS42537.1.
RefSeqiNP_001001415.2. NM_001001415.2.
UniGeneiHs.572567.
Hs.709598.

Genome annotation databases

EnsembliENST00000358491; ENSP00000351280; ENSG00000197013.
GeneIDi353088.
KEGGihsa:353088.
UCSCiuc002nqd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010615 Genomic DNA. No translation available.
AY269786 mRNA. Translation: AAP30884.1. Sequence problems.
AF325191 mRNA. Translation: AAK01422.1. Sequence problems.
BM996292 mRNA. No translation available.
CCDSiCCDS42537.1.
RefSeqiNP_001001415.2. NM_001001415.2.
UniGeneiHs.572567.
Hs.709598.

3D structure databases

ProteinModelPortaliQ86V71.
SMRiQ86V71. Positions 143-646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351280.

PTM databases

iPTMnetiQ86V71.
PhosphoSiteiQ86V71.

Polymorphism and mutation databases

BioMutaiZNF429.
DMDMi218511972.

Proteomic databases

EPDiQ86V71.
PaxDbiQ86V71.
PeptideAtlasiQ86V71.
PRIDEiQ86V71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358491; ENSP00000351280; ENSG00000197013.
GeneIDi353088.
KEGGihsa:353088.
UCSCiuc002nqd.2. human.

Organism-specific databases

CTDi353088.
GeneCardsiZNF429.
HGNCiHGNC:20817. ZNF429.
neXtProtiNX_Q86V71.
PharmGKBiPA134910790.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86V71.
KOiK09228.
OMAiIRENTYR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86V71.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF429. human.
GenomeRNAii353088.
PROiQ86V71.

Gene expression databases

BgeeiENSG00000197013.
CleanExiHS_ZNF429.
ExpressionAtlasiQ86V71. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN429_HUMAN
AccessioniPrimary (citable) accession number: Q86V71
Secondary accession number(s): A6NLV7, Q9BZE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.