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Protein

Zinc finger protein 429

Gene

ZNF429

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 429
Gene namesi
Name:ZNF429
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197013.9
HGNCiHGNC:20817 ZNF429
neXtProtiNX_Q86V71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi353088
OpenTargetsiENSG00000197013
PharmGKBiPA134910790

Polymorphism and mutation databases

BioMutaiZNF429
DMDMi218511972

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475771 – 674Zinc finger protein 429Add BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei605PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86V71
MaxQBiQ86V71
PaxDbiQ86V71
PeptideAtlasiQ86V71
PRIDEiQ86V71

PTM databases

iPTMnetiQ86V71
PhosphoSitePlusiQ86V71

Expressioni

Gene expression databases

BgeeiENSG00000197013
CleanExiHS_ZNF429
ExpressionAtlasiQ86V71 baseline and differential

Organism-specific databases

HPAiHPA004139

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351280

Structurei

3D structure databases

ProteinModelPortaliQ86V71
SMRiQ86V71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000145214
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ86V71
KOiK09228
OMAiIRENTYR
OrthoDBiEOG091G02KC
PhylomeDBiQ86V71
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

Sequencei

Sequence statusi: Complete.

Q86V71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLTFTDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEKEK EPCKMKRHEM VDEPPVVCSH FAEDFWPEQD IKDSFQKVTL
110 120 130 140 150
RRYDKRGHEN LQLRKGYKTV GDCKLYKGGY NGLNQCLTLT QSKMYHCDIY
160 170 180 190 200
VKVFYAFSNA DRYKTRHTGK KPFQCKKCGK SFCMLSQLTQ HKKIHIRENT
210 220 230 240 250
YRCKEFGNAF NQSSALTNHK RIYVGEKHYR CEECGKAFNH YSTLTNHKRI
260 270 280 290 300
HTGEKPYKCK ECGKAFSRYS TLTTHKRIHS GEKPYKCDEC GKTFSISSTF
310 320 330 340 350
TKHKIIHTEE KPYKCKECGK AFNRSSTLTS HKRIHTGEKP YKCEECGKAF
360 370 380 390 400
NWSSTLTKHK VIHTGEKPYK CEECGKAFNQ SSRLTRHKKI HTGEEPYKFE
410 420 430 440 450
KCGRVFTCSS TLTQDKKIHT GEKPYNCEEC GKVFTYSSTL TRHKRIHTEE
460 470 480 490 500
KPYKCNECGK AFNRSSHLTS HRRIHTGEKP YKCEECGKAF KQSSNLNSHK
510 520 530 540 550
KIHSGEKPYK CEECGKAFIL SSRLTQHKKI HTGEKPYKCE ECGKAFNRSS
560 570 580 590 600
RLTQHKKIHT GEKPYKCKQC DKAFTHSSNL SSHKKIHSGE KPYKCEECGK
610 620 630 640 650
AFNRSSRLTQ HKKIHTREKP YKCEECAKAF TRSSRLTQHK KIHRMGVVAH
660 670
ACNPSTLGGR GGRITRSGDR DRPG
Length:674
Mass (Da):78,152
Last modified:December 16, 2008 - v2
Checksum:iC48BC76B58059FE7
GO

Sequence cautioni

The sequence AAK01422 differs from that shown.Curated
The sequence AAK01422 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAP30884 differs from that shown.Curated
The sequence AAP30884 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167H → Y in AAP30884 (Ref. 2) Curated1
Sequence conflicti167H → Y in AAK01422 (PubMed:7865130).Curated1
Sequence conflicti206 – 207FG → CC in AAP30884 (Ref. 2) Curated2
Sequence conflicti206 – 207FG → CC in AAK01422 (PubMed:7865130).Curated2
Sequence conflicti249 – 276Missing in AAP30884 (Ref. 2) CuratedAdd BLAST28
Sequence conflicti249 – 276Missing in AAK01422 (PubMed:7865130).CuratedAdd BLAST28
Sequence conflicti252T → S in AAP30884 (Ref. 2) Curated1
Sequence conflicti252T → S in AAK01422 (PubMed:7865130).Curated1
Sequence conflicti337G → V in AAP30884 (Ref. 2) Curated1
Sequence conflicti337G → V in AAK01422 (PubMed:7865130).Curated1
Sequence conflicti361V → I in AAP30884 (Ref. 2) Curated1
Sequence conflicti361V → I in AAK01422 (PubMed:7865130).Curated1
Sequence conflicti367K → N in AAK01422 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047848650H → Y. Corresponds to variant dbSNP:rs2562473Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010615 Genomic DNA No translation available.
AY269786 mRNA Translation: AAP30884.1 Sequence problems.
AF325191 mRNA Translation: AAK01422.1 Sequence problems.
BM996292 mRNA No translation available.
CCDSiCCDS42537.1
RefSeqiNP_001001415.2, NM_001001415.3
UniGeneiHs.572567
Hs.659553
Hs.709598

Genome annotation databases

EnsembliENST00000358491; ENSP00000351280; ENSG00000197013
GeneIDi353088
KEGGihsa:353088
UCSCiuc002nqd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN429_HUMAN
AccessioniPrimary (citable) accession number: Q86V71
Secondary accession number(s): A6NLV7, Q9BZE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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