Q86V60 (Q86V60_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
PTPRM protein EMBL AAH51651.1

Gene names

Name:

PTPRM EMBL AAH51651.1

Organism

Homo sapiens (Human) EMBL AAH51651.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1390 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. SAAS SAAS016130

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase SAAS SAAS016130
PTM	Disulfide bond SAAS SAAS013151
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q86V60 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D8173543CDDD9F79	FASTA	1,390	156,937
	10 20 30 40 50 60 MPSGSFMLVN ASGRPEGQRA HLLLPQLKEN DTHCIDFHYF VSSKSNSPPG LLNVYVKVNN 70 80 90 100 110 120 GPLGNPIWNI SGDPARTWNR AELAISTFWP NFYQVIFEVI TSGHQGYLAI DEVKVLGHPC 130 140 150 160 170 180 TRTPHFLRIQ NVEVNAGQFA TFQCSAIGRT VAGDRLWLQG IDVRDAPLKE IKVTSSRRFI 190 200 210 220 230 240 ASFNVVNTTK RDAGKYRCMI RTEGGVGISN YAELVVKEPP VPIAPPQLAS VGATYLWIQL 250 260 270 280 290 300 NANSINGDGP IVAREVEYCT ASGSWNDRQP VDSTSYKIGH LDPDTEYEIS VLLTRPGEGG 310 320 330 340 350 360 TGSPGPALRT RTKCADPMRG PRKLEVVEVK SRQITISWEP FGYNVTRCHS YNLTVHYCYQ 370 380 390 400 410 420 VGGQEQVREE VSWDTENSHP QHTITNLSPY TNVSVKLILM NPEGRKESQE LIVQTDEDLP 430 440 450 460 470 480 GAVPTESIQG STFEEKIFLQ WREPTQTYGV ITLYEITYKA VSSFDPEIDL SNQSGRVSKL 490 500 510 520 530 540 GNETHFLFFG LYPGTTYSFT IRASTAKGFG PPATNQFTTK ISAPSMPAYE LETPLNQTDN 550 560 570 580 590 600 TVTVMLKPAH SRGAPVSVYQ IVVEEERPRR TKKTTEILKC YPVPIHFQNA SLLNSQYYFA 610 620 630 640 650 660 AEFPADSLQA AQPFTIGDNK TYNGYWNTPL LPYKSYRIYF QAASRANGET KIDCVQVATK 670 680 690 700 710 720 GAATPKPVPE PEKQTDHTVK IAGVIAGILL FVIIFLGVVL VMKKRKLAKK RKETMSSTRQ 730 740 750 760 770 780 EMTVMVNSMD KSYAEQGTNC DEAFSFMDTH NLNGRSVSSP SSFTMKTNTL STSVPNSYYP 790 800 810 820 830 840 DETHTMASDT SSLVQSHTYK KREPADVPYQ TGQLHPAIRV ADLLQHITQM KCAEGYGFKE 850 860 870 880 890 900 EYESFFEGQS APWDSAKKGE NRMKNRYGNI IAYDHSRVRL QTIEGDTNSD YINGNYIDGY 910 920 930 940 950 960 HRPNHYIATQ GPMQETIYDF WRMVWHENTA SIIMVTNLVE VGRVKCCKYW PDDTEIYKDI 970 980 990 1000 1010 1020 KVTLIETELL AEYVIRTFAV EKRGVHEIRE IRQFHFTGWP DRGVPYHATG LLGFVRQVKS 1030 1040 1050 1060 1070 1080 KSPPSAGPLV VHCSAGAGRT GCFIVIDIML DMAEREGVVD IYNCVRELRS RRVNMVQTEE 1090 1100 1110 1120 1130 1140 QYVFIHDAIL EACLCGDTSV PASQVRSLYY DMNKLDPQTN SSQIKEEFRT LNMVTPTLRV 1150 1160 1170 1180 1190 1200 EDCSIALLPR NHEKNRCMDI LPPDRCLPFL ITIDGESSNY INAALMDSYK QPSAFIVTQH 1210 1220 1230 1240 1250 1260 PLPNTVKDFW RLVLDYHCTS VVMLNDVDPA QLCPQYWPEN GVHRHGPIQV EFVSADLEED 1270 1280 1290 1300 1310 1320 IISRIFRIYN AARPQDGYRM VQQFQFLGWP MYRDTPVSKR SFLKLIRQVD KWQEEYNGGE 1330 1340 1350 1360 1370 1380 GRTVVHCLNG GGRSGTFCAI SIVCEMLRHQ RTVDVFHAVK TLRNNKPNMV DLLDQYKFCY 1390 EVALEYLNSG

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAH51651.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC051651 mRNA. Translation: AAH51651.1.
IPI	IPI00293849.
UniGene	Hs.49774.
3D structure databases
HSSP	HSSP built from PDB template 1RPM based on UniProtKB P28827.
ProteinModelPortal	Q86V60.
SMR	Q86V60. Positions 1-526, 817-1094.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG062785.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR003961. Fibronectin_type3. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013151. Immunoglobulin. IPR000998. MAM_dom. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00041. fn3. 2 hits. PF00047. ig. 1 hit. PF00629. MAM. 1 hit. PF00102. Y_phosphatase. 2 hits. [Graphical view]
PRINTS	PR00020. MAMDOMAIN. PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 4 hits. SM00409. IG. 1 hit. SM00194. PTPc. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit. SSF49265. FN_III-like. 3 hits.
PROSITE	PS50853. FN3. 3 hits. PS50835. IG_LIKE. 1 hit. PS00740. MAM_1. 1 hit. PS50060. MAM_2. 1 hit. PS00383. TYR_PHOSPHATASE_1. 2 hits. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PTPRM. human.

Entry information

Entry name

Q86V60_HUMAN

Accession

Primary (citable) accession number: Q86V60

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.