Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PNMA-like protein 1

Gene

PNMAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
PNMA-like protein 1
Gene namesi
Name:PNMAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25578. PNMAL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399835.

Polymorphism and mutation databases

BioMutaiPNMAL1.
DMDMi74727539.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439PNMA-like protein 1PRO_0000325836Add
BLAST

Proteomic databases

EPDiQ86V59.
MaxQBiQ86V59.
PaxDbiQ86V59.
PeptideAtlasiQ86V59.
PRIDEiQ86V59.

PTM databases

iPTMnetiQ86V59.
PhosphoSiteiQ86V59.

Expressioni

Gene expression databases

BgeeiENSG00000182013.
CleanExiHS_PNMAL1.
ExpressionAtlasiQ86V59. baseline and differential.
GenevisibleiQ86V59. HS.

Organism-specific databases

HPAiHPA012956.

Interactioni

Protein-protein interaction databases

BioGridi120523. 7 interactions.
IntActiQ86V59. 2 interactions.
MINTiMINT-4719531.
STRINGi9606.ENSP00000318131.

Structurei

3D structure databases

ProteinModelPortaliQ86V59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410IKIG. Eukaryota.
ENOG41116VX. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000115592.
HOVERGENiHBG108276.
InParanoidiQ86V59.
OMAiEGRTWED.
OrthoDBiEOG091G0BG9.
PhylomeDBiQ86V59.
TreeFamiTF335054.

Family and domain databases

InterProiIPR026523. PNMA.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 2 hits.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86V59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKTMAMNLL EDWCRGMEVD IHRSLLVTGI PEDCGQAEIE ETLNGVLSPL
60 70 80 90 100
GPYRVLNKIF VREENVKAAL IEVGEGVNLS TIPREFPGRG GVWRVVCRDP
110 120 130 140 150
TQDAEFLKNL NEFLDAEGRT WEDVVRLLQL NHPTLSQNQH QPPENWAEAL
160 170 180 190 200
GVLLGAVVQI IFCMDAEIRS REEARAQEAA EFEEMAAWAL AAGRKVKKEP
210 220 230 240 250
GLAAEVGSAL KAETPNNWNA TEDQHEPTKP LVRRAGAKSR SRRKKQKKNS
260 270 280 290 300
RQEAVPWKKP KGINSNSTAN LEDPEVGDAE SMAISEPIKG SRKPCVNKEE
310 320 330 340 350
LALKKPMAKC AWKGPREPPQ DARAEAESPG GASESDQDGG HESPPKKKAV
360 370 380 390 400
AWVSAKNPAP MRKKKKVSLG PVSYVLVDSE DGRKKPVMPK KGPGSRREAS
410 420 430
DQKAPRGQQP AEATASTSRG PKAKPEGSPR RATNESRKV
Length:439
Mass (Da):48,161
Last modified:December 7, 2004 - v2
Checksum:i43E43FA1CAEC1E81
GO
Isoform 2 (identifier: Q86V59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-378: VSLGPVSYVLVD → NPERFDLGDHPY
     379-439: Missing.

Show »
Length:378
Mass (Da):41,864
Checksum:i3386C5CAB2EBA3F6
GO

Sequence cautioni

The sequence BAA91804 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF82907 differs from that shown.Probable cloning artifact. Aberrant splice sites.Curated
The sequence BAF82907 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence EAW57420 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti319 – 3191P → S in AAH32508 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801S → T.
Corresponds to variant rs12610254 [ dbSNP | Ensembl ].
VAR_039935
Natural varianti97 – 971C → Y.
Corresponds to variant rs7248888 [ dbSNP | Ensembl ].
VAR_039936

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei367 – 37812VSLGP…YVLVD → NPERFDLGDHPY in isoform 2. 1 PublicationVSP_032441Add
BLAST
Alternative sequencei379 – 43961Missing in isoform 2. 1 PublicationVSP_032442Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834344 mRNA. Translation: CAD39010.1.
CH471126 Genomic DNA. Translation: EAW57420.1. Different initiation.
CH471126 Genomic DNA. Translation: EAW57421.1.
BC026026 mRNA. Translation: AAH26026.2.
BC032508 mRNA. Translation: AAH32508.1.
BC051688 mRNA. Translation: AAH51688.2.
AK001643 mRNA. Translation: BAA91804.1. Different initiation.
AK290218 mRNA. Translation: BAF82907.1. Sequence problems.
CCDSiCCDS33059.1. [Q86V59-1]
CCDS46124.1. [Q86V59-2]
RefSeqiNP_001096619.1. NM_001103149.1. [Q86V59-2]
NP_060685.2. NM_018215.3. [Q86V59-1]
UniGeneiHs.8395.

Genome annotation databases

EnsembliENST00000313683; ENSP00000318131; ENSG00000182013. [Q86V59-1]
ENST00000438932; ENSP00000410273; ENSG00000182013. [Q86V59-2]
GeneIDi55228.
KEGGihsa:55228.
UCSCiuc002peq.5. human. [Q86V59-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834344 mRNA. Translation: CAD39010.1.
CH471126 Genomic DNA. Translation: EAW57420.1. Different initiation.
CH471126 Genomic DNA. Translation: EAW57421.1.
BC026026 mRNA. Translation: AAH26026.2.
BC032508 mRNA. Translation: AAH32508.1.
BC051688 mRNA. Translation: AAH51688.2.
AK001643 mRNA. Translation: BAA91804.1. Different initiation.
AK290218 mRNA. Translation: BAF82907.1. Sequence problems.
CCDSiCCDS33059.1. [Q86V59-1]
CCDS46124.1. [Q86V59-2]
RefSeqiNP_001096619.1. NM_001103149.1. [Q86V59-2]
NP_060685.2. NM_018215.3. [Q86V59-1]
UniGeneiHs.8395.

3D structure databases

ProteinModelPortaliQ86V59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120523. 7 interactions.
IntActiQ86V59. 2 interactions.
MINTiMINT-4719531.
STRINGi9606.ENSP00000318131.

PTM databases

iPTMnetiQ86V59.
PhosphoSiteiQ86V59.

Polymorphism and mutation databases

BioMutaiPNMAL1.
DMDMi74727539.

Proteomic databases

EPDiQ86V59.
MaxQBiQ86V59.
PaxDbiQ86V59.
PeptideAtlasiQ86V59.
PRIDEiQ86V59.

Protocols and materials databases

DNASUi55228.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313683; ENSP00000318131; ENSG00000182013. [Q86V59-1]
ENST00000438932; ENSP00000410273; ENSG00000182013. [Q86V59-2]
GeneIDi55228.
KEGGihsa:55228.
UCSCiuc002peq.5. human. [Q86V59-1]

Organism-specific databases

CTDi55228.
GeneCardsiPNMAL1.
H-InvDBHIX0015252.
HGNCiHGNC:25578. PNMAL1.
HPAiHPA012956.
neXtProtiNX_Q86V59.
PharmGKBiPA162399835.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKIG. Eukaryota.
ENOG41116VX. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000115592.
HOVERGENiHBG108276.
InParanoidiQ86V59.
OMAiEGRTWED.
OrthoDBiEOG091G0BG9.
PhylomeDBiQ86V59.
TreeFamiTF335054.

Miscellaneous databases

ChiTaRSiPNMAL1. human.
GeneWikiiFLJ10781.
GenomeRNAii55228.
PROiQ86V59.

Gene expression databases

BgeeiENSG00000182013.
CleanExiHS_PNMAL1.
ExpressionAtlasiQ86V59. baseline and differential.
GenevisibleiQ86V59. HS.

Family and domain databases

InterProiIPR026523. PNMA.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 2 hits.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNML1_HUMAN
AccessioniPrimary (citable) accession number: Q86V59
Secondary accession number(s): A8K2F3
, Q5U638, Q8N3H4, Q9NVE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.