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Protein

Leucine zipper protein 1

Gene

LUZP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper protein 1
Gene namesi
Name:LUZP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14985. LUZP1.

Subcellular locationi

  • Nucleus

  • Note: Also detected in soma and dendrites of neurons.By similarity

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30487.

Polymorphism and mutation databases

BioMutaiLUZP1.
DMDMi97072093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 10761075Leucine zipper protein 1PRO_0000234550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources1 Publication
Modified residuei394 – 3941PhosphoserineCombined sources
Modified residuei570 – 5701PhosphoserineCombined sources
Modified residuei574 – 5741PhosphoserineCombined sources
Modified residuei611 – 6111PhosphoserineCombined sources
Modified residuei659 – 6591PhosphoserineCombined sources
Modified residuei679 – 6791PhosphothreonineCombined sources
Modified residuei690 – 6901PhosphoserineCombined sources
Modified residuei745 – 7451PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86V48.
MaxQBiQ86V48.
PaxDbiQ86V48.
PRIDEiQ86V48.

PTM databases

iPTMnetiQ86V48.
PhosphoSiteiQ86V48.

Expressioni

Gene expression databases

BgeeiQ86V48.
CleanExiHS_LUZP1.
ExpressionAtlasiQ86V48. baseline and differential.
GenevisibleiQ86V48. HS.

Organism-specific databases

HPAiHPA028506.
HPA028542.

Interactioni

Protein-protein interaction databases

BioGridi113574. 72 interactions.
DIPiDIP-33113N.
IntActiQ86V48. 63 interactions.
MINTiMINT-4535525.
STRINGi9606.ENSP00000303758.

Structurei

3D structure databases

ProteinModelPortaliQ86V48.
SMRiQ86V48. Positions 309-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili11 – 359349Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJB9. Eukaryota.
ENOG410Y6B5. LUCA.
GeneTreeiENSGT00680000099614.
HOGENOMiHOG000246948.
HOVERGENiHBG081939.
InParanoidiQ86V48.
OMAiAWNHSAG.
OrthoDBiEOG7T4MJS.
PhylomeDBiQ86V48.
TreeFamiTF331399.

Family and domain databases

InterProiIPR026734. Luzp1.
[Graphical view]
PANTHERiPTHR23166:SF7. PTHR23166:SF7. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86V48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK
60 70 80 90 100
VIQAEGSNSS MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE
110 120 130 140 150
NLTRELKSEI ERLQKRMAEL EKLEEAFSRS KNDCTQLCLS LNEERNLTKK
160 170 180 190 200
ISSELEMLRV KVKELESSED RLDKTEQSLA SELEKLKSLT LSFVSERKYL
210 220 230 240 250
NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL RIEDGISSTL
260 270 280 290 300
PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT
310 320 330 340 350
QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ
360 370 380 390 400
KELENGEVEG EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE
410 420 430 440 450
RLRNREFALN NENYSLSNRQ VSSPSFTNRR AAKASHMGVS TDSGTQETKK
460 470 480 490 500
TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA AQEHSKAWKG TSKPGTESGL
510 520 530 540 550
KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG KRGHVLGNGS
560 570 580 590 600
QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP
610 620 630 640 650
VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK
660 670 680 690 700
SSGREKPDSD DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP
710 720 730 740 750
RTSLFENDKD AGMENESVKS VRASTNTMEL PDTNGAGVKS QRPFSPREAL
760 770 780 790 800
RSRAIIKPVI VDKDVKKIMG GSGTETTLEK QKPVSKPGPN KVTSSITIYP
810 820 830 840 850
SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS PFELSIHKHD
860 870 880 890 900
ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR
910 920 930 940 950
WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN
960 970 980 990 1000
AYTQRSSTDF SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS
1010 1020 1030 1040 1050
EVLTRRNRVG DTITVAAWNH SASMEEEGED CTLSVYRQLH NSLDPSELPG
1060 1070
KQGLPESGRV RAEERLRPTR PCAEEN
Length:1,076
Mass (Da):120,275
Last modified:May 16, 2006 - v2
Checksum:i682D8C008BE77F1A
GO
Isoform 2 (identifier: Q86V48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1025: E → SS
     1026-1076: Missing.

Note: No experimental confirmation available.
Show »
Length:1,026
Mass (Da):114,588
Checksum:iCC0F7FCB98E24787
GO
Isoform 3 (identifier: Q86V48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1025: E → VSSSLSPLSLFSLPFPSLPFPFSPLLWPV
     1026-1076: Missing.

Note: No experimental confirmation available.
Show »
Length:1,053
Mass (Da):117,555
Checksum:iAE160A5A76046E9C
GO

Sequence cautioni

The sequence AAH33219.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI19705.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251R → P in BAB84979 (PubMed:12693554).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171S → A.
Corresponds to variant rs12091554 [ dbSNP | Ensembl ].
VAR_056932
Natural varianti458 – 4581G → S.2 Publications
Corresponds to variant rs477830 [ dbSNP | Ensembl ].
VAR_026283
Natural varianti461 – 4611Q → K.2 Publications
Corresponds to variant rs3765407 [ dbSNP | Ensembl ].
VAR_026284
Natural varianti491 – 4911T → I.
Corresponds to variant rs35917050 [ dbSNP | Ensembl ].
VAR_056933
Natural varianti868 – 8681D → N.2 Publications
Corresponds to variant rs10799790 [ dbSNP | Ensembl ].
VAR_026285
Natural varianti1034 – 10341S → N.
Corresponds to variant rs12066671 [ dbSNP | Ensembl ].
VAR_056934

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1025 – 10251E → SS in isoform 2. 1 PublicationVSP_018351
Alternative sequencei1025 – 10251E → VSSSLSPLSLFSLPFPSLPF PFSPLLWPV in isoform 3. 1 PublicationVSP_018352
Alternative sequencei1026 – 107651Missing in isoform 2 and isoform 3. 2 PublicationsVSP_018353Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031428 Genomic DNA. Translation: CAI19705.1. Sequence problems.
BC033219 mRNA. Translation: AAH33219.1. Different initiation.
BC051733 mRNA. Translation: AAH51733.1.
AK074153 mRNA. Translation: BAB84979.1.
CCDSiCCDS30628.1. [Q86V48-1]
RefSeqiNP_001136018.1. NM_001142546.1. [Q86V48-1]
NP_361013.3. NM_033631.3. [Q86V48-1]
XP_011540392.1. XM_011542090.1. [Q86V48-1]
XP_011540393.1. XM_011542091.1. [Q86V48-1]
UniGeneiHs.257900.

Genome annotation databases

EnsembliENST00000302291; ENSP00000303758; ENSG00000169641. [Q86V48-1]
ENST00000314174; ENSP00000313705; ENSG00000169641. [Q86V48-2]
ENST00000418342; ENSP00000393460; ENSG00000169641. [Q86V48-1]
GeneIDi7798.
KEGGihsa:7798.
UCSCiuc001bgl.4. human. [Q86V48-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031428 Genomic DNA. Translation: CAI19705.1. Sequence problems.
BC033219 mRNA. Translation: AAH33219.1. Different initiation.
BC051733 mRNA. Translation: AAH51733.1.
AK074153 mRNA. Translation: BAB84979.1.
CCDSiCCDS30628.1. [Q86V48-1]
RefSeqiNP_001136018.1. NM_001142546.1. [Q86V48-1]
NP_361013.3. NM_033631.3. [Q86V48-1]
XP_011540392.1. XM_011542090.1. [Q86V48-1]
XP_011540393.1. XM_011542091.1. [Q86V48-1]
UniGeneiHs.257900.

3D structure databases

ProteinModelPortaliQ86V48.
SMRiQ86V48. Positions 309-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113574. 72 interactions.
DIPiDIP-33113N.
IntActiQ86V48. 63 interactions.
MINTiMINT-4535525.
STRINGi9606.ENSP00000303758.

PTM databases

iPTMnetiQ86V48.
PhosphoSiteiQ86V48.

Polymorphism and mutation databases

BioMutaiLUZP1.
DMDMi97072093.

Proteomic databases

EPDiQ86V48.
MaxQBiQ86V48.
PaxDbiQ86V48.
PRIDEiQ86V48.

Protocols and materials databases

DNASUi7798.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302291; ENSP00000303758; ENSG00000169641. [Q86V48-1]
ENST00000314174; ENSP00000313705; ENSG00000169641. [Q86V48-2]
ENST00000418342; ENSP00000393460; ENSG00000169641. [Q86V48-1]
GeneIDi7798.
KEGGihsa:7798.
UCSCiuc001bgl.4. human. [Q86V48-1]

Organism-specific databases

CTDi7798.
GeneCardsiLUZP1.
H-InvDBHIX0000240.
HGNCiHGNC:14985. LUZP1.
HPAiHPA028506.
HPA028542.
MIMi601422. gene.
neXtProtiNX_Q86V48.
PharmGKBiPA30487.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJB9. Eukaryota.
ENOG410Y6B5. LUCA.
GeneTreeiENSGT00680000099614.
HOGENOMiHOG000246948.
HOVERGENiHBG081939.
InParanoidiQ86V48.
OMAiAWNHSAG.
OrthoDBiEOG7T4MJS.
PhylomeDBiQ86V48.
TreeFamiTF331399.

Miscellaneous databases

ChiTaRSiLUZP1. human.
GenomeRNAii7798.
PROiQ86V48.
SOURCEiSearch...

Gene expression databases

BgeeiQ86V48.
CleanExiHS_LUZP1.
ExpressionAtlasiQ86V48. baseline and differential.
GenevisibleiQ86V48. HS.

Family and domain databases

InterProiIPR026734. Luzp1.
[Graphical view]
PANTHERiPTHR23166:SF7. PTHR23166:SF7. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 856-1076 (ISOFORM 1), VARIANTS SER-458; LYS-461 AND ASN-868.
    Tissue: Pancreas and Testis.
  3. Bienvenut W.V., Dozynkiewicz M., Norman J.C.
    Submitted (JUN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-14 AND 673-691, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  4. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-1076 (ISOFORM 3), VARIANTS SER-458; LYS-461 AND ASN-868.
    Tissue: Spleen.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; SER-659 AND SER-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570; SER-659; THR-679 AND SER-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-574; SER-659; SER-690 AND SER-745, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-611 AND SER-659, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiLUZP1_HUMAN
AccessioniPrimary (citable) accession number: Q86V48
Secondary accession number(s): Q5TH93, Q8N4X3, Q8TEH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.