Q86V48 (LUZP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine zipper protein 1

Gene names

Name:

LUZP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1076 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus. Note: Also detected in soma and dendrites of neurons By similarity.
Sequence caution	The sequence AAH33219.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI19705.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	artery development Inferred from electronic annotation. Source: Compara neural fold bending Inferred from electronic annotation. Source: Compara ventricular septum development Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86V48-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86V48-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1025: E → SS
     1026-1076: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q86V48-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1025: E → VSSSLSPLSLFSLPFPSLPFPFSPLLWPV
     1026-1076: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 1076	1075	Leucine zipper protein 1		PRO_0000234550
Regions
	Coiled coil	11 – 359	349	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.3
	Modified residue	394	1	Phosphoserine Ref.5
	Modified residue	570	1	Phosphoserine Ref.7
	Modified residue	574	1	Phosphoserine Ref.8
	Modified residue	611	1	Phosphoserine Ref.9
	Modified residue	659	1	Phosphoserine Ref.5 Ref.7 Ref.8 Ref.9
	Modified residue	679	1	Phosphothreonine Ref.7
	Modified residue	690	1	Phosphoserine Ref.5 Ref.7 Ref.8
	Modified residue	745	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1025	1	E → SS in isoform 2.		VSP_018351
	Alternative sequence	1025	1	E → VSSSLSPLSLFSLPFPSLPF PFSPLLWPV in isoform 3.		VSP_018352
	Alternative sequence	1026 – 1076	51	Missing in isoform 2 and isoform 3.		VSP_018353
	Natural variant	317	1	S → A. Corresponds to variant rs12091554 [ dbSNP | Ensembl ].		VAR_056932
	Natural variant	458	1	G → S. Ref.2 Ref.4 Corresponds to variant rs477830 [ dbSNP | Ensembl ].		VAR_026283
	Natural variant	461	1	Q → K. Ref.2 Ref.4 Corresponds to variant rs3765407 [ dbSNP | Ensembl ].		VAR_026284
	Natural variant	491	1	T → I. Corresponds to variant rs35917050 [ dbSNP | Ensembl ].		VAR_056933
	Natural variant	868	1	D → N. Ref.2 Ref.4 Corresponds to variant rs10799790 [ dbSNP | Ensembl ].		VAR_026285
	Natural variant	1034	1	S → N. Corresponds to variant rs12066671 [ dbSNP | Ensembl ].		VAR_056934
Experimental info
	Sequence conflict	25	1	R → P in BAB84979. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: 682D8C008BE77F1A	FASTA	1,076	120,275
	10 20 30 40 50 60 MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK VIQAEGSNSS 70 80 90 100 110 120 MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE NLTRELKSEI ERLQKRMAEL 130 140 150 160 170 180 EKLEEAFSRS KNDCTQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLA 190 200 210 220 230 240 SELEKLKSLT LSFVSERKYL NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL 250 260 270 280 290 300 RIEDGISSTL PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT 310 320 330 340 350 360 QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ KELENGEVEG 370 380 390 400 410 420 EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE RLRNREFALN NENYSLSNRQ 430 440 450 460 470 480 VSSPSFTNRR AAKASHMGVS TDSGTQETKK TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA 490 500 510 520 530 540 AQEHSKAWKG TSKPGTESGL KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG 550 560 570 580 590 600 KRGHVLGNGS QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP 610 620 630 640 650 660 VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK SSGREKPDSD 670 680 690 700 710 720 DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP RTSLFENDKD AGMENESVKS 730 740 750 760 770 780 VRASTNTMEL PDTNGAGVKS QRPFSPREAL RSRAIIKPVI VDKDVKKIMG GSGTETTLEK 790 800 810 820 830 840 QKPVSKPGPN KVTSSITIYP SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS 850 860 870 880 890 900 PFELSIHKHD ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR 910 920 930 940 950 960 WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN AYTQRSSTDF 970 980 990 1000 1010 1020 SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS EVLTRRNRVG DTITVAAWNH 1030 1040 1050 1060 1070 SASMEEEGED CTLSVYRQLH NSLDPSELPG KQGLPESGRV RAEERLRPTR PCAEEN
	Isoform 2 [UniParc]. Checksum: CC0F7FCB98E24787	FASTA	1,026	114,588
	10 20 30 40 50 60 MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK VIQAEGSNSS 70 80 90 100 110 120 MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE NLTRELKSEI ERLQKRMAEL 130 140 150 160 170 180 EKLEEAFSRS KNDCTQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLA 190 200 210 220 230 240 SELEKLKSLT LSFVSERKYL NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL 250 260 270 280 290 300 RIEDGISSTL PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT 310 320 330 340 350 360 QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ KELENGEVEG 370 380 390 400 410 420 EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE RLRNREFALN NENYSLSNRQ 430 440 450 460 470 480 VSSPSFTNRR AAKASHMGVS TDSGTQETKK TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA 490 500 510 520 530 540 AQEHSKAWKG TSKPGTESGL KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG 550 560 570 580 590 600 KRGHVLGNGS QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP 610 620 630 640 650 660 VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK SSGREKPDSD 670 680 690 700 710 720 DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP RTSLFENDKD AGMENESVKS 730 740 750 760 770 780 VRASTNTMEL PDTNGAGVKS QRPFSPREAL RSRAIIKPVI VDKDVKKIMG GSGTETTLEK 790 800 810 820 830 840 QKPVSKPGPN KVTSSITIYP SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS 850 860 870 880 890 900 PFELSIHKHD ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR 910 920 930 940 950 960 WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN AYTQRSSTDF 970 980 990 1000 1010 1020 SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS EVLTRRNRVG DTITVAAWNH SASMSS
	Isoform 3 [UniParc]. Checksum: AE160A5A76046E9C	FASTA	1,053	117,555
	10 20 30 40 50 60 MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK VIQAEGSNSS 70 80 90 100 110 120 MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE NLTRELKSEI ERLQKRMAEL 130 140 150 160 170 180 EKLEEAFSRS KNDCTQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLA 190 200 210 220 230 240 SELEKLKSLT LSFVSERKYL NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL 250 260 270 280 290 300 RIEDGISSTL PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT 310 320 330 340 350 360 QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ KELENGEVEG 370 380 390 400 410 420 EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE RLRNREFALN NENYSLSNRQ 430 440 450 460 470 480 VSSPSFTNRR AAKASHMGVS TDSGTQETKK TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA 490 500 510 520 530 540 AQEHSKAWKG TSKPGTESGL KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG 550 560 570 580 590 600 KRGHVLGNGS QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP 610 620 630 640 650 660 VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK SSGREKPDSD 670 680 690 700 710 720 DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP RTSLFENDKD AGMENESVKS 730 740 750 760 770 780 VRASTNTMEL PDTNGAGVKS QRPFSPREAL RSRAIIKPVI VDKDVKKIMG GSGTETTLEK 790 800 810 820 830 840 QKPVSKPGPN KVTSSITIYP SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS 850 860 870 880 890 900 PFELSIHKHD ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR 910 920 930 940 950 960 WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN AYTQRSSTDF 970 980 990 1000 1010 1020 SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS EVLTRRNRVG DTITVAAWNH 1030 1040 1050 SASMVSSSLS PLSLFSLPFP SLPFPFSPLL WPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 856-1076 (ISOFORM 1), VARIANTS SER-458; LYS-461 AND ASN-868. Tissue: Pancreas and Testis.
[3]	Bienvenut W.V., Dozynkiewicz M., Norman J.C. Submitted (JUN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-14 AND 673-691, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Ovarian carcinoma.
[4]	"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones." Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O. DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-1076 (ISOFORM 3), VARIANTS SER-458; LYS-461 AND ASN-868. Tissue: Spleen.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; SER-659 AND SER-690, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570; SER-659; THR-679 AND SER-690, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-574; SER-659; SER-690 AND SER-745, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-611 AND SER-659, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL031428 Genomic DNA. Translation: CAI19705.1. Sequence problems. BC033219 mRNA. Translation: AAH33219.1. Different initiation. BC051733 mRNA. Translation: AAH51733.1. AK074153 mRNA. Translation: BAB84979.1.
IPI	IPI00296830. IPI00395737. IPI00744623.
RefSeq	NP_001136018.1. NM_001142546.1. NP_361013.3. NM_033631.3.
UniGene	Hs.257900.
3D structure databases
ProteinModelPortal	Q86V48.
SMR	Q86V48. Positions 326-353.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-33113N.
IntAct	Q86V48. 2 interactions.
STRING	9606.ENSP00000363752.
PTM databases
PhosphoSite	Q86V48.
Polymorphism databases
DMDM	97072093.
Proteomic databases
PaxDb	Q86V48.
PRIDE	Q86V48.
Protocols and materials databases
DNASU	7798.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302291; ENSP00000303758; ENSG00000169641. ENST00000314174; ENSP00000313705; ENSG00000169641. ENST00000374623; ENSP00000363752; ENSG00000169641. ENST00000418342; ENSP00000393460; ENSG00000169641.
GeneID	7798.
KEGG	hsa:7798.
UCSC	uc001bgk.2. human. uc001bgl.3. human.
Organism-specific databases
CTD	7798.
GeneCards	GC01M023410.
H-InvDB	HIX0000240.
HGNC	HGNC:14985. LUZP1.
HPA	HPA028506. HPA028542.
MIM	601422. gene.
neXtProt	NX_Q86V48.
PharmGKB	PA30487.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG10839.
HOGENOM	HOG000246948.
HOVERGEN	HBG081939.
InParanoid	Q86V48.
OMA	VKKIMGG.
Gene expression databases
ArrayExpress	Q86V48.
Bgee	Q86V48.
CleanEx	HS_LUZP1.
Genevestigator	Q86V48.
GermOnline	ENSG00000169641. Homo sapiens.
Family and domain databases
InterPro	IPR026734. Luzp1. [Graphical view]
PANTHER	PTHR23166:SF1. PTHR23166:SF1. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	LUZP1. human.
GenomeRNAi	7798.
NextBio	30166.
SOURCE	Search...

Entry information

Entry name

LUZP1_HUMAN

Accession

Primary (citable) accession number: Q86V48
Secondary accession number(s): Q5TH93, Q8N4X3, Q8TEH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.