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Protein

Leucine zipper protein 1

Gene

LUZP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper protein 1
Gene namesi
Name:LUZP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000169641.13
HGNCiHGNC:14985 LUZP1
MIMi601422 gene
neXtProtiNX_Q86V48

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169641
PharmGKBiPA30487

Polymorphism and mutation databases

BioMutaiLUZP1
DMDMi97072093

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002345502 – 1076Leucine zipper protein 1Add BLAST1075

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei255PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei570PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1
Modified residuei611PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei679PhosphothreonineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei745PhosphoserineCombined sources1
Modified residuei905PhosphoserineCombined sources1
Modified residuei932PhosphoserineCombined sources1
Modified residuei958PhosphothreonineCombined sources1
Modified residuei995PhosphoserineCombined sources1
Modified residuei1042PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86V48
MaxQBiQ86V48
PaxDbiQ86V48
PeptideAtlasiQ86V48
PRIDEiQ86V48

PTM databases

CarbonylDBiQ86V48
iPTMnetiQ86V48
PhosphoSitePlusiQ86V48

Expressioni

Gene expression databases

BgeeiENSG00000169641
CleanExiHS_LUZP1
ExpressionAtlasiQ86V48 baseline and differential
GenevisibleiQ86V48 HS

Organism-specific databases

HPAiHPA028506
HPA028542

Interactioni

Protein-protein interaction databases

BioGridi113574, 84 interactors
DIPiDIP-33113N
IntActiQ86V48, 64 interactors
STRINGi9606.ENSP00000303758

Structurei

3D structure databases

ProteinModelPortaliQ86V48
SMRiQ86V48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 359Sequence analysisAdd BLAST349

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJB9 Eukaryota
ENOG410Y6B5 LUCA
GeneTreeiENSGT00910000144112
HOGENOMiHOG000246948
HOVERGENiHBG081939
InParanoidiQ86V48
OMAiAWNHSAG
OrthoDBiEOG091G01LW
PhylomeDBiQ86V48
TreeFamiTF331399

Family and domain databases

InterProiView protein in InterPro
IPR026734 Luzp1
PANTHERiPTHR23166:SF7 PTHR23166:SF7, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86V48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEFTSYKET ASSRHLRFKL QSLSRRLDEL EEATKNLQKA EDELLDLQDK
60 70 80 90 100
VIQAEGSNSS MLAEIEVLRQ RVLRIEGKDE EIKRAEDLCR LMKEKLEEEE
110 120 130 140 150
NLTRELKSEI ERLQKRMAEL EKLEEAFSRS KNDCTQLCLS LNEERNLTKK
160 170 180 190 200
ISSELEMLRV KVKELESSED RLDKTEQSLA SELEKLKSLT LSFVSERKYL
210 220 230 240 250
NEKEKENEKL IKELTQKLEQ NKKMNRDYTR NASNLERNDL RIEDGISSTL
260 270 280 290 300
PSKESRRKGG LDYLKQVENE TRNKSENEKN RNQEDNKVKD LNQEIEKLKT
310 320 330 340 350
QIKHFESLEE ELKKMKSKNN DLQDNYLSEQ NKNKLLASQL EEIKLQIKKQ
360 370 380 390 400
KELENGEVEG EDAFLSSKGR HERTKFRGHG SEASVSKHTA RELSPQHKRE
410 420 430 440 450
RLRNREFALN NENYSLSNRQ VSSPSFTNRR AAKASHMGVS TDSGTQETKK
460 470 480 490 500
TEDRFVPGSS QSEGKKSREQ PSVLSRYPPA AQEHSKAWKG TSKPGTESGL
510 520 530 540 550
KGKVEKTTRT FSDTTHGSVP SDPLGRADKA SDTSSETVFG KRGHVLGNGS
560 570 580 590 600
QVTQAANSGC SKAIGALASS RRSSSEGLSK GKKAANGLEA DNSCPNSKAP
610 620 630 640 650
VLSKYPYSCR SQENILQGFS TSHKEGVNQP AAVVMEDSSP HEALRCRVIK
660 670 680 690 700
SSGREKPDSD DDLDIASLVT AKLVNTTITP EPEPKPQPNS REKAKTRGAP
710 720 730 740 750
RTSLFENDKD AGMENESVKS VRASTNTMEL PDTNGAGVKS QRPFSPREAL
760 770 780 790 800
RSRAIIKPVI VDKDVKKIMG GSGTETTLEK QKPVSKPGPN KVTSSITIYP
810 820 830 840 850
SDSSSPRAAP GEALRERHTS TSNIQVGLAE LTSVSNHVSS PFELSIHKHD
860 870 880 890 900
ITLQLAEAER MADGPLKDRP ETVVSRSSII IKPSDPVERN SHAPPAETIR
910 920 930 940 950
WKSHSAPSEV GFSDARHVTV RNAWKSRRDL KSLEDPPTRI GKNVESTNSN
960 970 980 990 1000
AYTQRSSTDF SELEQPRSCL FEQGTRRVGP SSGDAPEPSS RRTQSSLTVS
1010 1020 1030 1040 1050
EVLTRRNRVG DTITVAAWNH SASMEEEGED CTLSVYRQLH NSLDPSELPG
1060 1070
KQGLPESGRV RAEERLRPTR PCAEEN
Length:1,076
Mass (Da):120,275
Last modified:May 16, 2006 - v2
Checksum:i682D8C008BE77F1A
GO
Isoform 2 (identifier: Q86V48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1025: E → SS
     1026-1076: Missing.

Note: No experimental confirmation available.
Show »
Length:1,026
Mass (Da):114,588
Checksum:iCC0F7FCB98E24787
GO
Isoform 3 (identifier: Q86V48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1025: E → VSSSLSPLSLFSLPFPSLPFPFSPLLWPV
     1026-1076: Missing.

Note: No experimental confirmation available.
Show »
Length:1,053
Mass (Da):117,555
Checksum:iAE160A5A76046E9C
GO

Sequence cautioni

The sequence AAH33219 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI19705 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25R → P in BAB84979 (PubMed:12693554).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056932317S → A. Corresponds to variant dbSNP:rs12091554Ensembl.1
Natural variantiVAR_026283458G → S2 PublicationsCorresponds to variant dbSNP:rs477830Ensembl.1
Natural variantiVAR_026284461Q → K2 PublicationsCorresponds to variant dbSNP:rs3765407Ensembl.1
Natural variantiVAR_056933491T → I. Corresponds to variant dbSNP:rs35917050Ensembl.1
Natural variantiVAR_026285868D → N2 PublicationsCorresponds to variant dbSNP:rs10799790Ensembl.1
Natural variantiVAR_0569341034S → N. Corresponds to variant dbSNP:rs12066671Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183511025E → SS in isoform 2. 1 Publication1
Alternative sequenceiVSP_0183521025E → VSSSLSPLSLFSLPFPSLPF PFSPLLWPV in isoform 3. 1 Publication1
Alternative sequenceiVSP_0183531026 – 1076Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031428 Genomic DNA Translation: CAI19705.1 Sequence problems.
BC033219 mRNA Translation: AAH33219.1 Different initiation.
BC051733 mRNA Translation: AAH51733.1
AK074153 mRNA Translation: BAB84979.1
CCDSiCCDS30628.1 [Q86V48-1]
RefSeqiNP_001136018.1, NM_001142546.1 [Q86V48-1]
NP_361013.3, NM_033631.3 [Q86V48-1]
XP_011540392.1, XM_011542090.2 [Q86V48-1]
XP_011540393.1, XM_011542091.2 [Q86V48-1]
XP_016857741.1, XM_017002252.1 [Q86V48-1]
UniGeneiHs.257900

Genome annotation databases

EnsembliENST00000302291; ENSP00000303758; ENSG00000169641 [Q86V48-1]
ENST00000314174; ENSP00000313705; ENSG00000169641 [Q86V48-2]
ENST00000418342; ENSP00000393460; ENSG00000169641 [Q86V48-1]
GeneIDi7798
KEGGihsa:7798
UCSCiuc001bgl.4 human [Q86V48-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiLUZP1_HUMAN
AccessioniPrimary (citable) accession number: Q86V48
Secondary accession number(s): Q5TH93, Q8N4X3, Q8TEH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: May 23, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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