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Q86V35 (CABP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium-binding protein 7

Short name=CaBP7
Alternative name(s):
Calneuron II
Calneuron-2
Gene names
Name:CABP7
Synonyms:CALN2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity By similarity.

Subunit structure

Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner By similarity.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type IV membrane protein Probable. Cytoplasmperinuclear region. Cell membrane; Single-pass type IV membrane protein Probable Ref.2.

Domain

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.

Sequence similarities

Contains 2 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215Calcium-binding protein 7
PRO_0000073526

Regions

Topological domain1 – 188188Cytoplasmic Potential
Transmembrane189 – 20921Helical; Anchor for type IV membrane protein; Potential
Topological domain210 – 2156Extracellular Potential
Domain33 – 6836EF-hand 1
Domain69 – 10436EF-hand 2
Calcium binding46 – 57121 Ref.3
Calcium binding82 – 93122 Ref.3

Secondary structure

................. 215
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q86V35 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 9C254C955F7AFFA8

FASTA21524,453
        10         20         30         40         50         60 
MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN GFISKQELGT 

        70         80         90        100        110        120 
AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP KLSTSGIPEK FHGTDFDTVF 

       130        140        150        160        170        180 
WKCDMQKLTV DELKRLLYDT FCEHLSMKDI ENIIMTEEES HLGTAEECPV DVETCSNQQI 

       190        200        210 
RQTCVRKSLI CAFAIAFIIS VMLIAANQVL RSGMK 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8."
McCue H.V., Burgoyne R.D., Haynes L.P.
Biochem. Biophys. Res. Commun. 380:825-831(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[3]"Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking."
McCue H.V., Patel P., Herbert A.P., Lian L.Y., Burgoyne R.D., Haynes L.P.
J. Biol. Chem. 287:38231-38243(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 1-100, CALCIUM-BINDING SITES.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC051805 mRNA. Translation: AAH51805.1.
RefSeqNP_872333.1. NM_182527.2.
UniGeneHs.643608.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LV7NMR-A1-100[»]
ProteinModelPortalQ86V35.
SMRQ86V35. Positions 1-154.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000216144.

PTM databases

PhosphoSiteQ86V35.

Polymorphism databases

DMDM37537777.

Proteomic databases

PaxDbQ86V35.
PRIDEQ86V35.

Protocols and materials databases

DNASU164633.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216144; ENSP00000216144; ENSG00000100314.
GeneID164633.
KEGGhsa:164633.
UCSCuc003agl.3. human.

Organism-specific databases

CTD164633.
GeneCardsGC22P030116.
HGNCHGNC:20834. CABP7.
HPAHPA016439.
neXtProtNX_Q86V35.
PharmGKBPA134928335.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000252990.
HOVERGENHBG050762.
InParanoidQ86V35.
OMAQQVKQTC.
OrthoDBEOG74R1RQ.
PhylomeDBQ86V35.
TreeFamTF331025.

Gene expression databases

BgeeQ86V35.
CleanExHS_CABP7.
GenevestigatorQ86V35.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi164633.
NextBio88474.
PROQ86V35.

Entry information

Entry nameCABP7_HUMAN
AccessionPrimary (citable) accession number: Q86V35
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM