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Q86V35

- CABP7_HUMAN

UniProt

Q86V35 - CABP7_HUMAN

Protein

Calcium-binding protein 7

Gene

CABP7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi46 – 57121Add
    BLAST
    Calcium bindingi82 – 93122Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-binding protein 7
    Short name:
    CaBP7
    Alternative name(s):
    Calneuron II
    Calneuron-2
    Gene namesi
    Name:CABP7
    Synonyms:CALN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:20834. CABP7.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane 1 Publication; Single-pass type IV membrane protein 1 Publication. Cytoplasmperinuclear region 1 Publication. Cell membrane 1 Publication; Single-pass type IV membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell
    4. trans-Golgi network membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134928335.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215Calcium-binding protein 7PRO_0000073526Add
    BLAST

    Proteomic databases

    PaxDbiQ86V35.
    PRIDEiQ86V35.

    PTM databases

    PhosphoSiteiQ86V35.

    Expressioni

    Gene expression databases

    BgeeiQ86V35.
    CleanExiHS_CABP7.
    GenevestigatoriQ86V35.

    Organism-specific databases

    HPAiHPA016439.

    Interactioni

    Subunit structurei

    Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000216144.

    Structurei

    Secondary structure

    1
    215
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 53
    Turni21 – 244
    Helixi32 – 343
    Helixi35 – 4410
    Helixi55 – 6410
    Turni71 – 733
    Helixi74 – 818
    Beta strandi86 – 894
    Helixi91 – 977

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LV7NMR-A1-100[»]
    ProteinModelPortaliQ86V35.
    SMRiQ86V35. Positions 1-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 188188CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini210 – 2156ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei189 – 20921Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 6836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini69 – 10436EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000252990.
    HOVERGENiHBG050762.
    InParanoidiQ86V35.
    OMAiQQVKQTC.
    OrthoDBiEOG74R1RQ.
    PhylomeDBiQ86V35.
    TreeFamiTF331025.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86V35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN    50
    GFISKQELGT AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP 100
    KLSTSGIPEK FHGTDFDTVF WKCDMQKLTV DELKRLLYDT FCEHLSMKDI 150
    ENIIMTEEES HLGTAEECPV DVETCSNQQI RQTCVRKSLI CAFAIAFIIS 200
    VMLIAANQVL RSGMK 215
    Length:215
    Mass (Da):24,453
    Last modified:June 1, 2003 - v1
    Checksum:i9C254C955F7AFFA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC051805 mRNA. Translation: AAH51805.1.
    CCDSiCCDS13867.1.
    RefSeqiNP_872333.1. NM_182527.2.
    UniGeneiHs.643608.

    Genome annotation databases

    EnsembliENST00000216144; ENSP00000216144; ENSG00000100314.
    GeneIDi164633.
    KEGGihsa:164633.
    UCSCiuc003agl.3. human.

    Polymorphism databases

    DMDMi37537777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC051805 mRNA. Translation: AAH51805.1 .
    CCDSi CCDS13867.1.
    RefSeqi NP_872333.1. NM_182527.2.
    UniGenei Hs.643608.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LV7 NMR - A 1-100 [» ]
    ProteinModelPortali Q86V35.
    SMRi Q86V35. Positions 1-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000216144.

    PTM databases

    PhosphoSitei Q86V35.

    Polymorphism databases

    DMDMi 37537777.

    Proteomic databases

    PaxDbi Q86V35.
    PRIDEi Q86V35.

    Protocols and materials databases

    DNASUi 164633.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216144 ; ENSP00000216144 ; ENSG00000100314 .
    GeneIDi 164633.
    KEGGi hsa:164633.
    UCSCi uc003agl.3. human.

    Organism-specific databases

    CTDi 164633.
    GeneCardsi GC22P030116.
    HGNCi HGNC:20834. CABP7.
    HPAi HPA016439.
    neXtProti NX_Q86V35.
    PharmGKBi PA134928335.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000252990.
    HOVERGENi HBG050762.
    InParanoidi Q86V35.
    OMAi QQVKQTC.
    OrthoDBi EOG74R1RQ.
    PhylomeDBi Q86V35.
    TreeFami TF331025.

    Miscellaneous databases

    GenomeRNAii 164633.
    NextBioi 88474.
    PROi Q86V35.

    Gene expression databases

    Bgeei Q86V35.
    CleanExi HS_CABP7.
    Genevestigatori Q86V35.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8."
      McCue H.V., Burgoyne R.D., Haynes L.P.
      Biochem. Biophys. Res. Commun. 380:825-831(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    3. "Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking."
      McCue H.V., Patel P., Herbert A.P., Lian L.Y., Burgoyne R.D., Haynes L.P.
      J. Biol. Chem. 287:38231-38243(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-100, CALCIUM-BINDING SITES.

    Entry informationi

    Entry nameiCABP7_HUMAN
    AccessioniPrimary (citable) accession number: Q86V35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3