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Protein

Calcium-binding protein 7

Gene

CABP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi46 – 571Add BLAST12
Calcium bindingi82 – 932Add BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 7
Short name:
CaBP7
Alternative name(s):
Calneuron II
Calneuron-2
Gene namesi
Name:CABP7
Synonyms:CALN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:20834. CABP7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 188CytoplasmicSequence analysisAdd BLAST188
Transmembranei189 – 209Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini210 – 215ExtracellularSequence analysis6

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100314.
PharmGKBiPA134928335.

Polymorphism and mutation databases

BioMutaiCABP7.
DMDMi37537777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735261 – 215Calcium-binding protein 7Add BLAST215

Proteomic databases

MaxQBiQ86V35.
PaxDbiQ86V35.
PeptideAtlasiQ86V35.
PRIDEiQ86V35.

PTM databases

iPTMnetiQ86V35.
PhosphoSitePlusiQ86V35.

Expressioni

Gene expression databases

BgeeiENSG00000100314.
CleanExiHS_CABP7.
GenevisibleiQ86V35. HS.

Organism-specific databases

HPAiHPA016439.

Interactioni

Subunit structurei

Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000216144.

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Turni21 – 24Combined sources4
Helixi32 – 34Combined sources3
Helixi35 – 44Combined sources10
Helixi55 – 64Combined sources10
Turni71 – 73Combined sources3
Helixi74 – 81Combined sources8
Beta strandi86 – 89Combined sources4
Helixi91 – 97Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LV7NMR-A1-100[»]
ProteinModelPortaliQ86V35.
SMRiQ86V35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 68EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini69 – 104EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Domaini

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
HOVERGENiHBG050762.
InParanoidiQ86V35.
OMAiCPVEVET.
OrthoDBiEOG091G0IOW.
PhylomeDBiQ86V35.
TreeFamiTF331025.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86V35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN
60 70 80 90 100
GFISKQELGT AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP
110 120 130 140 150
KLSTSGIPEK FHGTDFDTVF WKCDMQKLTV DELKRLLYDT FCEHLSMKDI
160 170 180 190 200
ENIIMTEEES HLGTAEECPV DVETCSNQQI RQTCVRKSLI CAFAIAFIIS
210
VMLIAANQVL RSGMK
Length:215
Mass (Da):24,453
Last modified:June 1, 2003 - v1
Checksum:i9C254C955F7AFFA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051805 mRNA. Translation: AAH51805.1.
CCDSiCCDS13867.1.
RefSeqiNP_872333.1. NM_182527.2.
UniGeneiHs.643608.

Genome annotation databases

EnsembliENST00000216144; ENSP00000216144; ENSG00000100314.
GeneIDi164633.
KEGGihsa:164633.
UCSCiuc003agl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051805 mRNA. Translation: AAH51805.1.
CCDSiCCDS13867.1.
RefSeqiNP_872333.1. NM_182527.2.
UniGeneiHs.643608.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LV7NMR-A1-100[»]
ProteinModelPortaliQ86V35.
SMRiQ86V35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000216144.

PTM databases

iPTMnetiQ86V35.
PhosphoSitePlusiQ86V35.

Polymorphism and mutation databases

BioMutaiCABP7.
DMDMi37537777.

Proteomic databases

MaxQBiQ86V35.
PaxDbiQ86V35.
PeptideAtlasiQ86V35.
PRIDEiQ86V35.

Protocols and materials databases

DNASUi164633.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216144; ENSP00000216144; ENSG00000100314.
GeneIDi164633.
KEGGihsa:164633.
UCSCiuc003agl.4. human.

Organism-specific databases

CTDi164633.
GeneCardsiCABP7.
HGNCiHGNC:20834. CABP7.
HPAiHPA016439.
neXtProtiNX_Q86V35.
OpenTargetsiENSG00000100314.
PharmGKBiPA134928335.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
HOVERGENiHBG050762.
InParanoidiQ86V35.
OMAiCPVEVET.
OrthoDBiEOG091G0IOW.
PhylomeDBiQ86V35.
TreeFamiTF331025.

Miscellaneous databases

ChiTaRSiCABP7. human.
GenomeRNAii164633.
PROiQ86V35.

Gene expression databases

BgeeiENSG00000100314.
CleanExiHS_CABP7.
GenevisibleiQ86V35. HS.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCABP7_HUMAN
AccessioniPrimary (citable) accession number: Q86V35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.