Q86V35 (CABP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium-binding protein 7
Short name=CaBP7

Alternative name(s):
Calneuron II
Calneuron-2

Gene names

Name:	CABP7
Synonyms:	CALN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity By similarity.
Subunit structure	Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner By similarity.
Subcellular location	Golgi apparatus › trans-Golgi network membrane; Single-pass type IV membrane protein Probable. Cytoplasm › perinuclear region. Cell membrane; Single-pass type IV membrane protein Probable Ref.2.
Domain	The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
Sequence similarities	Contains 2 EF-hand domains.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Golgi apparatus Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell trans-Golgi network membrane Inferred from direct assay Ref.2. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 215

215

Calcium-binding protein 7

PRO_0000073526

Regions

Topological domain

1 – 188

188

Cytoplasmic Potential

Transmembrane

189 – 209

21

Helical; Anchor for type IV membrane protein; Potential

Topological domain

210 – 215

6

Extracellular Potential

Domain

33 – 68

36

EF-hand 1

Domain

69 – 104

36

EF-hand 2

Calcium binding

46 – 57

12

1 Potential

Calcium binding

82 – 93

12

2 Potential

Amino acid modifications

Modified residue

16

1

Phosphotyrosine By similarity

Modified residue

17

1

Phosphothreonine By similarity

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

215

Helix Strand Turn

Details...

Beta strand

3 – 5

3

Turn

21 – 24

4

Helix

32 – 34

3

Helix

35 – 44

10

Helix

55 – 64

10

Turn

71 – 73

3

Helix

74 – 81

8

Beta strand

86 – 89

4

Helix

91 – 97

7

Sequences

	Sequence		Length	Mass (Da)
	Q86V35 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 9C254C955F7AFFA8	FASTA	215	24,453
	10 20 30 40 50 60 MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN GFISKQELGT 70 80 90 100 110 120 AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP KLSTSGIPEK FHGTDFDTVF 130 140 150 160 170 180 WKCDMQKLTV DELKRLLYDT FCEHLSMKDI ENIIMTEEES HLGTAEECPV DVETCSNQQI 190 200 210 RQTCVRKSLI CAFAIAFIIS VMLIAANQVL RSGMK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8." McCue H.V., Burgoyne R.D., Haynes L.P. Biochem. Biophys. Res. Commun. 380:825-831(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BC051805 mRNA. Translation: AAH51805.1.

IPI

IPI00095870.

RefSeq

NP_872333.1. NM_182527.2.

UniGene

Hs.643608.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LV7	NMR	-	A	1-100	[»]

ProteinModelPortal

Q86V35.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000216144.

PTM databases

PhosphoSite

Q86V35.

Polymorphism databases

DMDM

37537777.

Proteomic databases

PaxDb

Q86V35.

PRIDE

Q86V35.

Protocols and materials databases

DNASU

164633.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000216144; ENSP00000216144; ENSG00000100314.

GeneID

164633.

KEGG

hsa:164633.

UCSC

uc003agl.3. human.

Organism-specific databases

CTD

164633.

GeneCards

GC22P030116.

HGNC

HGNC:20834. CABP7.

HPA

HPA016439.

neXtProt

NX_Q86V35.

PharmGKB

PA134928335.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5126.

HOGENOM

HOG000252990.

HOVERGEN

HBG050762.

InParanoid

Q86V35.

OMA

ECPVEVE.

OrthoDB

EOG4BK54Q.

PhylomeDB

Q86V35.

Gene expression databases

Bgee

Q86V35.

CleanEx

HS_CABP7.

Genevestigator

Q86V35.

GermOnline

ENSG00000100314. Homo sapiens.

Family and domain databases

Gene3D

1.10.238.10. 1 hit.

InterPro

IPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]

Pfam

PF13499. EF_hand_5. 1 hit.
[Graphical view]

SMART

SM00054. EFh. 2 hits.
[Graphical view]

PROSITE

PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

164633.

NextBio

88474.

Entry information

Entry name

CABP7_HUMAN

Accession

Primary (citable) accession number: Q86V35

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.