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Q86V35

- CABP7_HUMAN

UniProt

Q86V35 - CABP7_HUMAN

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Protein

Calcium-binding protein 7

Gene
CABP7, CALN2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi46 – 571211 PublicationAdd
BLAST
Calcium bindingi82 – 931221 PublicationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 7
Short name:
CaBP7
Alternative name(s):
Calneuron II
Calneuron-2
Gene namesi
Name:CABP7
Synonyms:CALN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:20834. CABP7.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane; Single-pass type IV membrane protein Inferred. Cytoplasmperinuclear region. Cell membrane; Single-pass type IV membrane protein Inferred 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 188188Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei189 – 20921Helical; Anchor for type IV membrane protein; Reviewed predictionAdd
BLAST
Topological domaini210 – 2156Extracellular Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
  4. trans-Golgi network membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134928335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Calcium-binding protein 7PRO_0000073526Add
BLAST

Proteomic databases

PaxDbiQ86V35.
PRIDEiQ86V35.

PTM databases

PhosphoSiteiQ86V35.

Expressioni

Gene expression databases

BgeeiQ86V35.
CleanExiHS_CABP7.
GenevestigatoriQ86V35.

Organism-specific databases

HPAiHPA016439.

Interactioni

Subunit structurei

Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000216144.

Structurei

Secondary structure

1
215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53
Turni21 – 244
Helixi32 – 343
Helixi35 – 4410
Helixi55 – 6410
Turni71 – 733
Helixi74 – 818
Beta strandi86 – 894
Helixi91 – 977

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LV7NMR-A1-100[»]
ProteinModelPortaliQ86V35.
SMRiQ86V35. Positions 1-177.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 6836EF-hand 1Add
BLAST
Domaini69 – 10436EF-hand 2Add
BLAST

Domaini

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.

Sequence similaritiesi

Contains 2 EF-hand domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000252990.
HOVERGENiHBG050762.
InParanoidiQ86V35.
OMAiQQVKQTC.
OrthoDBiEOG74R1RQ.
PhylomeDBiQ86V35.
TreeFamiTF331025.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86V35-1 [UniParc]FASTAAdd to Basket

« Hide

MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN    50
GFISKQELGT AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP 100
KLSTSGIPEK FHGTDFDTVF WKCDMQKLTV DELKRLLYDT FCEHLSMKDI 150
ENIIMTEEES HLGTAEECPV DVETCSNQQI RQTCVRKSLI CAFAIAFIIS 200
VMLIAANQVL RSGMK 215
Length:215
Mass (Da):24,453
Last modified:June 1, 2003 - v1
Checksum:i9C254C955F7AFFA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC051805 mRNA. Translation: AAH51805.1.
CCDSiCCDS13867.1.
RefSeqiNP_872333.1. NM_182527.2.
UniGeneiHs.643608.

Genome annotation databases

EnsembliENST00000216144; ENSP00000216144; ENSG00000100314.
GeneIDi164633.
KEGGihsa:164633.
UCSCiuc003agl.3. human.

Polymorphism databases

DMDMi37537777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC051805 mRNA. Translation: AAH51805.1 .
CCDSi CCDS13867.1.
RefSeqi NP_872333.1. NM_182527.2.
UniGenei Hs.643608.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LV7 NMR - A 1-100 [» ]
ProteinModelPortali Q86V35.
SMRi Q86V35. Positions 1-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000216144.

PTM databases

PhosphoSitei Q86V35.

Polymorphism databases

DMDMi 37537777.

Proteomic databases

PaxDbi Q86V35.
PRIDEi Q86V35.

Protocols and materials databases

DNASUi 164633.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216144 ; ENSP00000216144 ; ENSG00000100314 .
GeneIDi 164633.
KEGGi hsa:164633.
UCSCi uc003agl.3. human.

Organism-specific databases

CTDi 164633.
GeneCardsi GC22P030116.
HGNCi HGNC:20834. CABP7.
HPAi HPA016439.
neXtProti NX_Q86V35.
PharmGKBi PA134928335.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5126.
HOGENOMi HOG000252990.
HOVERGENi HBG050762.
InParanoidi Q86V35.
OMAi QQVKQTC.
OrthoDBi EOG74R1RQ.
PhylomeDBi Q86V35.
TreeFami TF331025.

Miscellaneous databases

GenomeRNAii 164633.
NextBioi 88474.
PROi Q86V35.

Gene expression databases

Bgeei Q86V35.
CleanExi HS_CABP7.
Genevestigatori Q86V35.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view ]
Pfami PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8."
    McCue H.V., Burgoyne R.D., Haynes L.P.
    Biochem. Biophys. Res. Commun. 380:825-831(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking."
    McCue H.V., Patel P., Herbert A.P., Lian L.Y., Burgoyne R.D., Haynes L.P.
    J. Biol. Chem. 287:38231-38243(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-100, CALCIUM-BINDING SITES.

Entry informationi

Entry nameiCABP7_HUMAN
AccessioniPrimary (citable) accession number: Q86V35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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