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Protein

Calcium-binding protein 7

Gene

CABP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi46 – 57121Add
BLAST
Calcium bindingi82 – 93122Add
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 7
Short name:
CaBP7
Alternative name(s):
Calneuron II
Calneuron-2
Gene namesi
Name:CABP7
Synonyms:CALN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:20834. CABP7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 188188CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei189 – 20921Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST
Topological domaini210 – 2156ExtracellularSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134928335.

Polymorphism and mutation databases

BioMutaiCABP7.
DMDMi37537777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Calcium-binding protein 7PRO_0000073526Add
BLAST

Proteomic databases

PaxDbiQ86V35.
PRIDEiQ86V35.

PTM databases

PhosphoSiteiQ86V35.

Expressioni

Gene expression databases

BgeeiQ86V35.
CleanExiHS_CABP7.
GenevisibleiQ86V35. HS.

Organism-specific databases

HPAiHPA016439.

Interactioni

Subunit structurei

Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000216144.

Structurei

Secondary structure

1
215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Turni21 – 244Combined sources
Helixi32 – 343Combined sources
Helixi35 – 4410Combined sources
Helixi55 – 6410Combined sources
Turni71 – 733Combined sources
Helixi74 – 818Combined sources
Beta strandi86 – 894Combined sources
Helixi91 – 977Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LV7NMR-A1-100[»]
ProteinModelPortaliQ86V35.
SMRiQ86V35. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 6836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini69 – 10436EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
HOVERGENiHBG050762.
InParanoidiQ86V35.
OMAiQQVKQTC.
OrthoDBiEOG74R1RQ.
PhylomeDBiQ86V35.
TreeFamiTF331025.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86V35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN
60 70 80 90 100
GFISKQELGT AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP
110 120 130 140 150
KLSTSGIPEK FHGTDFDTVF WKCDMQKLTV DELKRLLYDT FCEHLSMKDI
160 170 180 190 200
ENIIMTEEES HLGTAEECPV DVETCSNQQI RQTCVRKSLI CAFAIAFIIS
210
VMLIAANQVL RSGMK
Length:215
Mass (Da):24,453
Last modified:June 1, 2003 - v1
Checksum:i9C254C955F7AFFA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051805 mRNA. Translation: AAH51805.1.
CCDSiCCDS13867.1.
RefSeqiNP_872333.1. NM_182527.2.
UniGeneiHs.643608.

Genome annotation databases

EnsembliENST00000216144; ENSP00000216144; ENSG00000100314.
GeneIDi164633.
KEGGihsa:164633.
UCSCiuc003agl.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051805 mRNA. Translation: AAH51805.1.
CCDSiCCDS13867.1.
RefSeqiNP_872333.1. NM_182527.2.
UniGeneiHs.643608.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LV7NMR-A1-100[»]
ProteinModelPortaliQ86V35.
SMRiQ86V35. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000216144.

PTM databases

PhosphoSiteiQ86V35.

Polymorphism and mutation databases

BioMutaiCABP7.
DMDMi37537777.

Proteomic databases

PaxDbiQ86V35.
PRIDEiQ86V35.

Protocols and materials databases

DNASUi164633.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216144; ENSP00000216144; ENSG00000100314.
GeneIDi164633.
KEGGihsa:164633.
UCSCiuc003agl.3. human.

Organism-specific databases

CTDi164633.
GeneCardsiGC22P030116.
HGNCiHGNC:20834. CABP7.
HPAiHPA016439.
neXtProtiNX_Q86V35.
PharmGKBiPA134928335.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
HOVERGENiHBG050762.
InParanoidiQ86V35.
OMAiQQVKQTC.
OrthoDBiEOG74R1RQ.
PhylomeDBiQ86V35.
TreeFamiTF331025.

Miscellaneous databases

ChiTaRSiCABP7. human.
GenomeRNAii164633.
NextBioi88474.
PROiQ86V35.

Gene expression databases

BgeeiQ86V35.
CleanExiHS_CABP7.
GenevisibleiQ86V35. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8."
    McCue H.V., Burgoyne R.D., Haynes L.P.
    Biochem. Biophys. Res. Commun. 380:825-831(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking."
    McCue H.V., Patel P., Herbert A.P., Lian L.Y., Burgoyne R.D., Haynes L.P.
    J. Biol. Chem. 287:38231-38243(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-100, CALCIUM-BINDING SITES.

Entry informationi

Entry nameiCABP7_HUMAN
AccessioniPrimary (citable) accession number: Q86V35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.