Q86V25 (VASH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vasohibin-2

Alternative name(s):
Vasohibin-like protein

Gene names

Name:	VASH2
Synonyms:	VASHL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Angiogenesis inhibitor. Inhibits network formation by endothelial cells. Ref.1
Developmental stage	Expressed in various embryonic organs at 6 to 12 embryonic weeks. Detected in vessels from 20-week embryonic organs as well as in endothelial cells from large vessels in neonate. Ref.1
Induction	By VEGF. Ref.1
Sequence similarities	Belongs to the vasohibin family.
Sequence caution	The sequence CAH71916.1 differs from that shown. Reason: Erroneous initiation. The sequence CAH71918.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of angiogenesis Inferred from direct assay. Source: MGI positive regulation of endothelial cell proliferation Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Inferred from direct assay. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86V25-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86V25-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q86V25-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.
     294-298: ILKPA → GLCSH
     299-355: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q86V25-4)

The sequence of this isoform differs from the canonical sequence as follows:
     167-169: YLT → THS
     170-355: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q86V25-5)

The sequence of this isoform differs from the canonical sequence as follows:
     122-166: QYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGI → H

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Vasohibin-2		PRO_0000189982
Natural variations
	Alternative sequence	1 – 142	142	Missing in isoform 3.		VSP_013329
	Alternative sequence	1 – 65	65	Missing in isoform 2.		VSP_013328
	Alternative sequence	122 – 166	45	QYNHT…VILGI → H in isoform 5.		VSP_013334
	Alternative sequence	167 – 169	3	YLT → THS in isoform 4.		VSP_013332
	Alternative sequence	170 – 355	186	Missing in isoform 4.		VSP_013333
	Alternative sequence	294 – 298	5	ILKPA → GLCSH in isoform 3.		VSP_013330
	Alternative sequence	299 – 355	57	Missing in isoform 3.		VSP_013331

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 12, 2005. Version 2. Checksum: C74C313FEF6A0837	FASTA	355	40,450
	10 20 30 40 50 60 MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS 70 80 90 100 110 120 HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT 130 140 150 160 170 180 LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI 190 200 210 220 230 240 SFKTYFSGNY FHHVVLGIYC NGRYGSLGMS RRAELMDKPL TFRTLSDLIF DFEDSYKKYL 250 260 270 280 290 300 HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA 310 320 330 340 350 HSPTQVRSRG KSLSPRRRQA SPPRRLGRRE KSPALPEKKV ADLSTLNEVG YQIRI
	Isoform 2 [UniParc]. Checksum: 21042C9BB88CAB7B	FASTA	290	33,538
	10 20 30 40 50 60 MWMHVAKVHP KGGEMVGAIR NAAFLAKPSI PQVPNYRLSM TIPDWLQAIQ NYMKTLQYNH 70 80 90 100 110 120 TGTQFFEIRK MRPLSGLMET AKEMTRESLP IKCLEAVILG IYLTNGQPSI ERFPISFKTY 130 140 150 160 170 180 FSGNYFHHVV LGIYCNGRYG SLGMSRRAEL MDKPLTFRTL SDLIFDFEDS YKKYLHTVKK 190 200 210 220 230 240 VKIGLYVPHE PHSFQPIEWK QLVLNVSKML RADIRKELEK YARDMRMKIL KPASAHSPTQ 250 260 270 280 290 VRSRGKSLSP RRRQASPPRR LGRREKSPAL PEKKVADLST LNEVGYQIRI
	Isoform 3 [UniParc]. Checksum: 4F1B7393CD050DCE	FASTA	156	18,271
	10 20 30 40 50 60 METAKEMTRE SLPIKCLEAV ILGIYLTNGQ PSIERFPISF KTYFSGNYFH HVVLGIYCNG 70 80 90 100 110 120 RYGSLGMSRR AELMDKPLTF RTLSDLIFDF EDSYKKYLHT VKKVKIGLYV PHEPHSFQPI 130 140 150 EWKQLVLNVS KMLRADIRKE LEKYARDMRM KGLCSH
	Isoform 4 [UniParc]. Checksum: E72AD1B6BB438113	FASTA	169	18,753
	10 20 30 40 50 60 MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS 70 80 90 100 110 120 HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT 130 140 150 160 LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGITHS
	Isoform 5 [UniParc]. Checksum: E7955D3D5C278530	FASTA	311	35,423
	10 20 30 40 50 60 MTGSAADTHR CPHPKGAKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS 70 80 90 100 110 120 HTWERMWMHV AKVHPKGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT 130 140 150 160 170 180 LHYLTNGQPS IERFPISFKT YFSGNYFHHV VLGIYCNGRY GSLGMSRRAE LMDKPLTFRT 190 200 210 220 230 240 LSDLIFDFED SYKKYLHTVK KVKIGLYVPH EPHSFQPIEW KQLVLNVSKM LRADIRKELE 250 260 270 280 290 300 KYARDMRMKI LKPASAHSPT QVRSRGKSLS PRRRQASPPR RLGRREKSPA LPEKKVADLS 310 TLNEVGYQIR I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin." Shibuya T., Watanabe K., Yamashita H., Shimizu K., Miyashita H., Abe M., Moriya T., Ohta H., Sonoda H., Shimosegawa T., Tabayashi K., Sato Y. Arterioscler. Thromb. Vasc. Biol. 26:1051-1057(2006) [PubMed: 16528006] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DEVELOPMENTAL STAGE, INDUCTION.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Teratocarcinoma.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5). Tissue: Brain and Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY834202 mRNA. Translation: AAX39752.1. AK022567 mRNA. Translation: BAB14103.1. AL592449 Genomic DNA. Translation: CAH71916.1. Different initiation. AL592449 Genomic DNA. Translation: CAH71917.1. AL592449 Genomic DNA. Translation: CAH71918.1. Different initiation. BC028194 mRNA. Translation: AAH28194.1. BC051856 mRNA. Translation: AAH51856.1. BC053836 mRNA. Translation: AAH53836.1.
IPI	IPI00328783. IPI00386499. IPI00555607. IPI00556467. IPI00940695.
RefSeq	NP_001129946.1. NM_001136474.1. NP_079025.2. NM_024749.3.
UniGene	Hs.96885.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q86V25.
PTM databases
PhosphoSite	Q86V25.
Proteomic databases
PRIDE	Q86V25.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366968; ENSP00000355935; ENSG00000143494.
GeneID	79805.
KEGG	hsa:79805.
UCSC	uc001hju.1. human. uc001hjw.1. human. uc001hjx.1. human. uc001hjy.1. human.
Organism-specific databases
CTD	79805.
GeneCards	GC01P213123.
HGNC	HGNC:25723. VASH2.
MIM	610471. gene.
neXtProt	NX_Q86V25.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10532.
GeneTree	ENSGT00390000012703.
HOVERGEN	HBG079337.
OMA	KFARDMR.
OrthoDB	EOG4N5VXD.
Gene expression databases
ArrayExpress	Q86V25.
Bgee	Q86V25.
CleanEx	HS_VASH2.
Genevestigator	Q86V25.
GermOnline	ENSG00000143494. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	69382.
SOURCE	Search...

Entry information

Entry name

VASH2_HUMAN

Accession

Primary (citable) accession number: Q86V25
Secondary accession number(s): Q2VT46 , Q5VTE7, Q5VTE9, Q7Z6E3, Q8IZ24, Q9H9W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	April 12, 2005
Last modified:	January 25, 2012
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.