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Q86V24 (ADR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified August 10, 2010. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
Customize displayNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Names and origin

Protein namesRecommended name:
Adiponectin receptor protein 2
Alternative name(s):
Progestin and adipoQ receptor family member II
Gene names
Name:ADIPOR2
Synonyms:PAQR2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Ref.5

Subunit structure

May form homo and heteromultimers. Ref.5

Subcellular location

Membrane; Multi-pass membrane protein. Note: Localized to the cell membrane and intracellular organelles. Ref.5

Tissue specificity

Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung. Ref.5 Ref.1

Domain

The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.

Sequence similarities

Belongs to the ADIPOR family.

Sequence caution

The sequence BAB15062.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfatty acid oxidation Ref.5

Inferred from sequence or structural similarity. Source: UniProtKB

hormone-mediated signaling pathway Ref.5

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionhormone binding Ref.5

Inferred from sequence or structural similarity. Source: UniProtKB

receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

APPL1Q9UKG13EBI-1769445,EBI-741243

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Adiponectin receptor protein 2
PRO_0000218829

Regions

Topological domain1 – 147147Cytoplasmic Potential
Transmembrane148 – 16821Helical; Name=1; Potential
Topological domain169 – 18113Extracellular Potential
Transmembrane182 – 20221Helical; Name=2; Potential
Topological domain203 – 22018Cytoplasmic Potential
Transmembrane221 – 24121Helical; Name=3; Potential
Topological domain242 – 2454Extracellular Potential
Transmembrane246 – 26621Helical; Name=4; Potential
Topological domain267 – 27812Cytoplasmic Potential
Transmembrane279 – 29921Helical; Name=5; Potential
Topological domain300 – 3078Extracellular Potential
Transmembrane308 – 32821Helical; Name=6; Potential
Topological domain329 – 34214Cytoplasmic Potential
Transmembrane343 – 36321Helical; Name=7; Potential
Topological domain364 – 38623Extracellular Potential

Natural variations

Natural variant391Q → R. [dbSNP:rs12298275]
VAR_048203

Experimental info

Sequence conflict1581F → S in BAB15062. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q86V24-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B3B0FF0BBF118AA1

FASTA38643,884
        10         20         30         40         50         60 
MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV LSSHHKKSSE 

        70         80         90        100        110        120 
EHEYSDEAPQ EDEGFMGMSP LLQAHHAMEK MEEFVCKVWE GRWRVIPHDV LPDWLKDNDF 

       130        140        150        160        170        180 
LLHGHRPPMP SFRACFKSIF RIHTETGNIW THLLGCVFFL CLGIFYMFRP NISFVAPLQE 

       190        200        210        220        230        240 
KVVFGLFFLG AILCLSFSWL FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY 

       250        260        270        280        290        300 
CNPQPCFIYL IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFLGLGLSGI IPTLHYVISE 

       310        320        330        340        350        360 
GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL FHIFVVAGAF 

       370        380 
VHFHGVSNLQ EFRFMIGGGC SEEDAL

« Hide

References

« Hide 'large scale' references
[1]"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
J. Mol. Evol. 61:372-380(2005) [PubMed: 16044242] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon, Hippocampus and Trachea.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[5]"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects."
Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y. expand/collapse author list , Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T.
Nature 423:762-769(2003) [PubMed: 12802337] [Abstract]
Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY.
+Additional computationally mapped references.

Web resources

Wikipedia

Adiponectin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY424280 mRNA. Translation: AAR08368.1.
AK025085 mRNA. Translation: BAB15062.1. Different initiation.
AK127196 mRNA. Translation: BAC86881.1.
AK128511 mRNA. Translation: BAC87473.1.
CH471116 Genomic DNA. Translation: EAW88924.1.
BC051858 mRNA. Translation: AAH51858.1.
IPIIPI00002224.
RefSeqNP_078827.2.
UniGeneHs.371642.

3D structure databases

ProteinModelPortalQ86V24.
ModBaseSearch...

Protein-protein interaction databases

IntActQ86V24. 3 interactions.
STRINGQ86V24.

Proteomic databases

PRIDEQ86V24.

Genome annotation databases

EnsemblENST00000357103; ENSP00000349616; ENSG00000006831; Homo sapiens. [Genome view]
GeneID79602.
KEGGhsa:79602.
UCSCuc001qjm.1. human.

Organism-specific databases

CTD79602.
GeneCardsGC12P001801.
H-InvDBHIX0010320.
HGNCHGNC:24041. ADIPOR2.
MIM607946. gene.
PharmGKBPA128394711.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG749828.
HOVERGENHBG013916.
InParanoidQ86V24.
OMANMSFVAP.
OrthoDBEOG93JFQD.
PhylomeDBQ86V24.

Gene expression databases

ArrayExpressQ86V24.
BgeeQ86V24.
CleanExHS_ADIPOR2.
GenevestigatorQ86V24.
GermOnlineENSG00000006831. Homo sapiens.

Family and domain databases

InterProIPR004254. HlyIII_related.
[Graphical view]
PANTHERPTHR20855. HlyIII_related. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio68634.
SOURCESearch...

Entry information

Entry nameADR2_HUMAN
AccessionPrimary (citable) accession number: Q86V24
Secondary accession number(s): Q53YY5, Q9H737
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: August 10, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents