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Q86V24

- ADR2_HUMAN

UniProt

Q86V24 - ADR2_HUMAN

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Protein

Adiponectin receptor protein 2

Gene

ADIPOR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.1 Publication

GO - Molecular functioni

  1. hormone binding Source: UniProtKB
  2. receptor activity Source: RefGenome

GO - Biological processi

  1. adiponectin-activated signaling pathway Source: RefGenome
  2. fatty acid oxidation Source: UniProtKB
  3. female pregnancy Source: Ensembl
  4. heart development Source: Ensembl
  5. hormone-mediated signaling pathway Source: UniProtKB
  6. negative regulation of cell growth Source: Ensembl
  7. positive regulation of glucose import Source: Ensembl
  8. response to nutrient Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Adiponectin receptor protein 2
Alternative name(s):
Progestin and adipoQ receptor family member II
Gene namesi
Name:ADIPOR2
Synonyms:PAQR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24041. ADIPOR2.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Localized to the cell membrane and intracellular organelles.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Adiponectin receptor protein 2PRO_0000218829Add
BLAST

Proteomic databases

MaxQBiQ86V24.
PaxDbiQ86V24.
PRIDEiQ86V24.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.2 Publications

Gene expression databases

BgeeiQ86V24.
CleanExiHS_ADIPOR2.
GenevestigatoriQ86V24.

Organism-specific databases

HPAiHPA043737.

Interactioni

Subunit structurei

May form homomultimer and heteromultimers.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL1Q9UKG13EBI-1769445,EBI-741243

Protein-protein interaction databases

BioGridi122739. 5 interactions.
IntActiQ86V24. 1 interaction.
STRINGi9606.ENSP00000349616.

Structurei

3D structure databases

ProteinModelPortaliQ86V24.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 147147CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini169 – 18113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini203 – 22018CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini242 – 2454ExtracellularSequence Analysis
Topological domaini267 – 27812CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini300 – 3078ExtracellularSequence Analysis
Topological domaini329 – 34214CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini364 – 38623ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei148 – 16821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei308 – 32821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei343 – 36321Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domaini

The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ86V24.
KOiK07297.
OMAiYMFRPNM.
OrthoDBiEOG7BS49P.
PhylomeDBiQ86V24.
TreeFamiTF313640.

Family and domain databases

InterProiIPR004254. HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86V24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV
60 70 80 90 100
LSSHHKKSSE EHEYSDEAPQ EDEGFMGMSP LLQAHHAMEK MEEFVCKVWE
110 120 130 140 150
GRWRVIPHDV LPDWLKDNDF LLHGHRPPMP SFRACFKSIF RIHTETGNIW
160 170 180 190 200
THLLGCVFFL CLGIFYMFRP NISFVAPLQE KVVFGLFFLG AILCLSFSWL
210 220 230 240 250
FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY CNPQPCFIYL
260 270 280 290 300
IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFLGLGLSGI IPTLHYVISE
310 320 330 340 350
GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL
360 370 380
FHIFVVAGAF VHFHGVSNLQ EFRFMIGGGC SEEDAL
Length:386
Mass (Da):43,884
Last modified:June 1, 2003 - v1
Checksum:iB3B0FF0BBF118AA1
GO

Sequence cautioni

The sequence BAB15062.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581F → S in BAB15062. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391Q → R.
Corresponds to variant rs12298275 [ dbSNP | Ensembl ].
VAR_048203

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY424280 mRNA. Translation: AAR08368.1.
AK025085 mRNA. Translation: BAB15062.1. Different initiation.
AK127196 mRNA. Translation: BAC86881.1.
AK128511 mRNA. Translation: BAC87473.1.
CH471116 Genomic DNA. Translation: EAW88924.1.
BC051858 mRNA. Translation: AAH51858.1.
CCDSiCCDS8511.1.
RefSeqiNP_078827.2. NM_024551.2.
XP_005253846.1. XM_005253789.1.
XP_006719081.1. XM_006719018.1.
UniGeneiHs.371642.

Genome annotation databases

EnsembliENST00000357103; ENSP00000349616; ENSG00000006831.
GeneIDi79602.
KEGGihsa:79602.
UCSCiuc001qjm.3. human.

Polymorphism databases

DMDMi38372190.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Adiponectin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY424280 mRNA. Translation: AAR08368.1 .
AK025085 mRNA. Translation: BAB15062.1 . Different initiation.
AK127196 mRNA. Translation: BAC86881.1 .
AK128511 mRNA. Translation: BAC87473.1 .
CH471116 Genomic DNA. Translation: EAW88924.1 .
BC051858 mRNA. Translation: AAH51858.1 .
CCDSi CCDS8511.1.
RefSeqi NP_078827.2. NM_024551.2.
XP_005253846.1. XM_005253789.1.
XP_006719081.1. XM_006719018.1.
UniGenei Hs.371642.

3D structure databases

ProteinModelPortali Q86V24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122739. 5 interactions.
IntActi Q86V24. 1 interaction.
STRINGi 9606.ENSP00000349616.

Chemistry

GuidetoPHARMACOLOGYi 650.

Polymorphism databases

DMDMi 38372190.

Proteomic databases

MaxQBi Q86V24.
PaxDbi Q86V24.
PRIDEi Q86V24.

Protocols and materials databases

DNASUi 79602.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357103 ; ENSP00000349616 ; ENSG00000006831 .
GeneIDi 79602.
KEGGi hsa:79602.
UCSCi uc001qjm.3. human.

Organism-specific databases

CTDi 79602.
GeneCardsi GC12P001801.
HGNCi HGNC:24041. ADIPOR2.
HPAi HPA043737.
MIMi 607946. gene.
neXtProti NX_Q86V24.
PharmGKBi PA128394711.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1272.
GeneTreei ENSGT00530000062926.
HOGENOMi HOG000197115.
HOVERGENi HBG013916.
InParanoidi Q86V24.
KOi K07297.
OMAi YMFRPNM.
OrthoDBi EOG7BS49P.
PhylomeDBi Q86V24.
TreeFami TF313640.

Miscellaneous databases

ChiTaRSi ADIPOR2. human.
GeneWikii ADIPOR2.
GenomeRNAii 79602.
NextBioi 68634.
PROi Q86V24.
SOURCEi Search...

Gene expression databases

Bgeei Q86V24.
CleanExi HS_ADIPOR2.
Genevestigatori Q86V24.

Family and domain databases

InterProi IPR004254. HlyIII-related.
[Graphical view ]
PANTHERi PTHR20855. PTHR20855. 1 hit.
Pfami PF03006. HlyIII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Hippocampus and Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY.

Entry informationi

Entry nameiADR2_HUMAN
AccessioniPrimary (citable) accession number: Q86V24
Secondary accession number(s): Q53YY5, Q9H737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3