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Q86V24

- ADR2_HUMAN

UniProt

Q86V24 - ADR2_HUMAN

Protein

Adiponectin receptor protein 2

Gene

ADIPOR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.1 Publication

    GO - Molecular functioni

    1. hormone binding Source: UniProtKB
    2. receptor activity Source: RefGenome

    GO - Biological processi

    1. adiponectin-activated signaling pathway Source: RefGenome
    2. fatty acid oxidation Source: UniProtKB
    3. female pregnancy Source: Ensembl
    4. heart development Source: Ensembl
    5. hormone-mediated signaling pathway Source: UniProtKB
    6. negative regulation of cell growth Source: Ensembl
    7. positive regulation of glucose import Source: Ensembl
    8. response to nutrient Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adiponectin receptor protein 2
    Alternative name(s):
    Progestin and adipoQ receptor family member II
    Gene namesi
    Name:ADIPOR2
    Synonyms:PAQR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24041. ADIPOR2.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Localized to the cell membrane and intracellular organelles.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394711.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386Adiponectin receptor protein 2PRO_0000218829Add
    BLAST

    Proteomic databases

    MaxQBiQ86V24.
    PaxDbiQ86V24.
    PRIDEiQ86V24.

    Expressioni

    Tissue specificityi

    Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.2 Publications

    Gene expression databases

    BgeeiQ86V24.
    CleanExiHS_ADIPOR2.
    GenevestigatoriQ86V24.

    Organism-specific databases

    HPAiHPA043737.

    Interactioni

    Subunit structurei

    May form homomultimer and heteromultimers.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APPL1Q9UKG13EBI-1769445,EBI-741243

    Protein-protein interaction databases

    BioGridi122739. 3 interactions.
    IntActiQ86V24. 1 interaction.
    STRINGi9606.ENSP00000349616.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86V24.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 147147CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 18113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini203 – 22018CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini242 – 2454ExtracellularSequence Analysis
    Topological domaini267 – 27812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini300 – 3078ExtracellularSequence Analysis
    Topological domaini329 – 34214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini364 – 38623ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei148 – 16821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.

    Sequence similaritiesi

    Belongs to the ADIPOR family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1272.
    HOGENOMiHOG000197115.
    HOVERGENiHBG013916.
    InParanoidiQ86V24.
    KOiK07297.
    OMAiYMFRPNM.
    OrthoDBiEOG7BS49P.
    PhylomeDBiQ86V24.
    TreeFamiTF313640.

    Family and domain databases

    InterProiIPR004254. HlyIII-related.
    [Graphical view]
    PANTHERiPTHR20855. PTHR20855. 1 hit.
    PfamiPF03006. HlyIII. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86V24-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV    50
    LSSHHKKSSE EHEYSDEAPQ EDEGFMGMSP LLQAHHAMEK MEEFVCKVWE 100
    GRWRVIPHDV LPDWLKDNDF LLHGHRPPMP SFRACFKSIF RIHTETGNIW 150
    THLLGCVFFL CLGIFYMFRP NISFVAPLQE KVVFGLFFLG AILCLSFSWL 200
    FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY CNPQPCFIYL 250
    IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFLGLGLSGI IPTLHYVISE 300
    GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL 350
    FHIFVVAGAF VHFHGVSNLQ EFRFMIGGGC SEEDAL 386
    Length:386
    Mass (Da):43,884
    Last modified:June 1, 2003 - v1
    Checksum:iB3B0FF0BBF118AA1
    GO

    Sequence cautioni

    The sequence BAB15062.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti158 – 1581F → S in BAB15062. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391Q → R.
    Corresponds to variant rs12298275 [ dbSNP | Ensembl ].
    VAR_048203

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424280 mRNA. Translation: AAR08368.1.
    AK025085 mRNA. Translation: BAB15062.1. Different initiation.
    AK127196 mRNA. Translation: BAC86881.1.
    AK128511 mRNA. Translation: BAC87473.1.
    CH471116 Genomic DNA. Translation: EAW88924.1.
    BC051858 mRNA. Translation: AAH51858.1.
    CCDSiCCDS8511.1.
    RefSeqiNP_078827.2. NM_024551.2.
    XP_005253846.1. XM_005253789.1.
    XP_006719081.1. XM_006719018.1.
    UniGeneiHs.371642.

    Genome annotation databases

    EnsembliENST00000357103; ENSP00000349616; ENSG00000006831.
    GeneIDi79602.
    KEGGihsa:79602.
    UCSCiuc001qjm.3. human.

    Polymorphism databases

    DMDMi38372190.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Adiponectin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424280 mRNA. Translation: AAR08368.1 .
    AK025085 mRNA. Translation: BAB15062.1 . Different initiation.
    AK127196 mRNA. Translation: BAC86881.1 .
    AK128511 mRNA. Translation: BAC87473.1 .
    CH471116 Genomic DNA. Translation: EAW88924.1 .
    BC051858 mRNA. Translation: AAH51858.1 .
    CCDSi CCDS8511.1.
    RefSeqi NP_078827.2. NM_024551.2.
    XP_005253846.1. XM_005253789.1.
    XP_006719081.1. XM_006719018.1.
    UniGenei Hs.371642.

    3D structure databases

    ProteinModelPortali Q86V24.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122739. 3 interactions.
    IntActi Q86V24. 1 interaction.
    STRINGi 9606.ENSP00000349616.

    Chemistry

    GuidetoPHARMACOLOGYi 650.

    Polymorphism databases

    DMDMi 38372190.

    Proteomic databases

    MaxQBi Q86V24.
    PaxDbi Q86V24.
    PRIDEi Q86V24.

    Protocols and materials databases

    DNASUi 79602.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357103 ; ENSP00000349616 ; ENSG00000006831 .
    GeneIDi 79602.
    KEGGi hsa:79602.
    UCSCi uc001qjm.3. human.

    Organism-specific databases

    CTDi 79602.
    GeneCardsi GC12P001801.
    HGNCi HGNC:24041. ADIPOR2.
    HPAi HPA043737.
    MIMi 607946. gene.
    neXtProti NX_Q86V24.
    PharmGKBi PA128394711.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1272.
    HOGENOMi HOG000197115.
    HOVERGENi HBG013916.
    InParanoidi Q86V24.
    KOi K07297.
    OMAi YMFRPNM.
    OrthoDBi EOG7BS49P.
    PhylomeDBi Q86V24.
    TreeFami TF313640.

    Miscellaneous databases

    ChiTaRSi ADIPOR2. human.
    GeneWikii ADIPOR2.
    GenomeRNAii 79602.
    NextBioi 68634.
    PROi Q86V24.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86V24.
    CleanExi HS_ADIPOR2.
    Genevestigatori Q86V24.

    Family and domain databases

    InterProi IPR004254. HlyIII-related.
    [Graphical view ]
    PANTHERi PTHR20855. PTHR20855. 1 hit.
    Pfami PF03006. HlyIII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
      Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
      J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon, Hippocampus and Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY.

    Entry informationi

    Entry nameiADR2_HUMAN
    AccessioniPrimary (citable) accession number: Q86V24
    Secondary accession number(s): Q53YY5, Q9H737
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3