Q86V24 (ADR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adiponectin receptor protein 2

Alternative name(s):
Progestin and adipoQ receptor family member II

Gene names

Name:	ADIPOR2
Synonyms:	PAQR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Ref.5
Subunit structure	May form homomultimer and heteromultimers. Ref.5
Subcellular location	Membrane; Multi-pass membrane protein. Note: Localized to the cell membrane and intracellular organelles. Ref.5
Tissue specificity	Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung. Ref.1 Ref.5
Domain	The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
Sequence similarities	Belongs to the ADIPOR family.
Sequence caution	The sequence BAB15062.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid oxidation Inferred from sequence or structural similarity Ref.5. Source: UniProtKB hormone-mediated signaling pathway Inferred from sequence or structural similarity Ref.5. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hormone binding Inferred from sequence or structural similarity Ref.5. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
APPL1	Q9UKG1	3	EBI-1769445,EBI-741243

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Adiponectin receptor protein 2		PRO_0000218829
Regions
	Topological domain	1 – 147	147	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Helical; Name=1; Potential
	Topological domain	169 – 181	13	Extracellular Potential
	Transmembrane	182 – 202	21	Helical; Name=2; Potential
	Topological domain	203 – 220	18	Cytoplasmic Potential
	Transmembrane	221 – 241	21	Helical; Name=3; Potential
	Topological domain	242 – 245	4	Extracellular Potential
	Transmembrane	246 – 266	21	Helical; Name=4; Potential
	Topological domain	267 – 278	12	Cytoplasmic Potential
	Transmembrane	279 – 299	21	Helical; Name=5; Potential
	Topological domain	300 – 307	8	Extracellular Potential
	Transmembrane	308 – 328	21	Helical; Name=6; Potential
	Topological domain	329 – 342	14	Cytoplasmic Potential
	Transmembrane	343 – 363	21	Helical; Name=7; Potential
	Topological domain	364 – 386	23	Extracellular Potential
Natural variations
	Natural variant	39	1	Q → R. Corresponds to variant rs12298275 [ dbSNP | Ensembl ].		VAR_048203
Experimental info
	Sequence conflict	158	1	F → S in BAB15062. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q86V24 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B3B0FF0BBF118AA1	FASTA	386	43,884
	10 20 30 40 50 60 MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV LSSHHKKSSE 70 80 90 100 110 120 EHEYSDEAPQ EDEGFMGMSP LLQAHHAMEK MEEFVCKVWE GRWRVIPHDV LPDWLKDNDF 130 140 150 160 170 180 LLHGHRPPMP SFRACFKSIF RIHTETGNIW THLLGCVFFL CLGIFYMFRP NISFVAPLQE 190 200 210 220 230 240 KVVFGLFFLG AILCLSFSWL FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY 250 260 270 280 290 300 CNPQPCFIYL IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFLGLGLSGI IPTLHYVISE 310 320 330 340 350 360 GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL FHIFVVAGAF 370 380 VHFHGVSNLQ EFRFMIGGGC SEEDAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Hippocampus and Trachea.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[5]	"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects." Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y. , Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T. Nature 423:762-769(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY.
+	Additional computationally mapped references.

Web resources

Wikipedia

Adiponectin entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY424280 mRNA. Translation: AAR08368.1. AK025085 mRNA. Translation: BAB15062.1. Different initiation. AK127196 mRNA. Translation: BAC86881.1. AK128511 mRNA. Translation: BAC87473.1. CH471116 Genomic DNA. Translation: EAW88924.1. BC051858 mRNA. Translation: AAH51858.1.
IPI	IPI00002224.
RefSeq	NP_078827.2. NM_024551.2.
UniGene	Hs.371642.
3D structure databases
ProteinModelPortal	Q86V24.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86V24. 1 interaction.
STRING	9606.ENSP00000349616.
Polymorphism databases
DMDM	38372190.
Proteomic databases
PaxDb	Q86V24.
PRIDE	Q86V24.
Protocols and materials databases
DNASU	79602.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357103; ENSP00000349616; ENSG00000006831.
GeneID	79602.
KEGG	hsa:79602.
UCSC	uc001qjm.3. human.
Organism-specific databases
CTD	79602.
GeneCards	GC12P001801.
HGNC	HGNC:24041. ADIPOR2.
HPA	HPA043737.
MIM	607946. gene.
neXtProt	NX_Q86V24.
PharmGKB	PA128394711.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1272.
HOGENOM	HOG000197115.
HOVERGEN	HBG013916.
InParanoid	Q86V24.
KO	K07297.
OMA	YMFRPNM.
OrthoDB	EOG408N8G.
PhylomeDB	Q86V24.
Gene expression databases
Bgee	Q86V24.
CleanEx	HS_ADIPOR2.
Genevestigator	Q86V24.
GermOnline	ENSG00000006831. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ADIPOR2. human.
GenomeRNAi	79602.
NextBio	68634.
SOURCE	Search...

Entry information

Entry name

ADR2_HUMAN

Accession

Primary (citable) accession number: Q86V24
Secondary accession number(s): Q53YY5, Q9H737

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.