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Protein

Adiponectin receptor protein 2

Gene

ADIPOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi202 – 2021Zinc1 Publication
Metal bindingi348 – 3481Zinc1 Publication
Metal bindingi352 – 3521Zinc1 Publication

GO - Molecular functioni

  • adipokinetic hormone receptor activity Source: UniProtKB
  • adiponectin binding Source: UniProtKB
  • hormone binding Source: GO_Central
  • receptor activity Source: GO_Central

GO - Biological processi

  • adiponectin-activated signaling pathway Source: UniProtKB
  • fatty acid oxidation Source: UniProtKB
  • female pregnancy Source: Ensembl
  • heart development Source: Ensembl
  • hormone-mediated signaling pathway Source: UniProtKB
  • negative regulation of cell growth Source: Ensembl
  • positive regulation of glucose import Source: Ensembl
  • response to nutrient Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Adiponectin receptor protein 2
Alternative name(s):
Progestin and adipoQ receptor family member II
Gene namesi
Name:ADIPOR2
Synonyms:PAQR21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24041. ADIPOR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 147147Cytoplasmic1 PublicationAdd
BLAST
Transmembranei148 – 16821Helical; Name=11 PublicationAdd
BLAST
Topological domaini169 – 18113Extracellular1 PublicationAdd
BLAST
Transmembranei182 – 20221Helical; Name=21 PublicationAdd
BLAST
Topological domaini203 – 21311Cytoplasmic1 PublicationAdd
BLAST
Transmembranei214 – 23421Helical; Name=31 PublicationAdd
BLAST
Topological domaini235 – 24511Extracellular1 PublicationAdd
BLAST
Transmembranei246 – 26621Helical; Name=41 PublicationAdd
BLAST
Topological domaini267 – 2737Cytoplasmic1 Publication
Transmembranei274 – 29421Helical; Name=51 PublicationAdd
BLAST
Topological domaini295 – 30915Extracellular1 PublicationAdd
BLAST
Transmembranei310 – 33021Helical; Name=61 PublicationAdd
BLAST
Topological domaini331 – 34818Cytoplasmic1 PublicationAdd
BLAST
Transmembranei349 – 36921Helical; Name=71 PublicationAdd
BLAST
Topological domaini370 – 38617Extracellular1 PublicationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi202 – 2021H → A: Abolishes response to ADIPOQ binding; when associated with A-219; A-348 and A-352. 1 Publication
Mutagenesisi219 – 2191D → A: Impairs response to ADIPOQ binding. Abolishes response to ADIPOQ binding; when associated with A-202; A-348 and A-352. 1 Publication
Mutagenesisi348 – 3481H → A: Impairs response to ADIPOQ binding. Abolishes response to ADIPOQ binding; when associated with A-202; A-219 and A-352. 1 Publication
Mutagenesisi352 – 3521H → A: Abolishes response to ADIPOQ binding; when associated with A-202; A-219 and A-348. 1 Publication

Organism-specific databases

PharmGKBiPA128394711.

Polymorphism and mutation databases

BioMutaiADIPOR2.
DMDMi38372190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Adiponectin receptor protein 2PRO_0000218829Add
BLAST

Proteomic databases

MaxQBiQ86V24.
PaxDbiQ86V24.
PRIDEiQ86V24.

Expressioni

Tissue specificityi

Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337).2 Publications

Gene expression databases

BgeeiQ86V24.
CleanExiHS_ADIPOR2.
GenevisibleiQ86V24. HS.

Organism-specific databases

HPAiHPA043737.

Interactioni

Subunit structurei

May form homooligomers and heterooligomers with ADIPOR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL1Q9UKG13EBI-1769445,EBI-741243

Protein-protein interaction databases

BioGridi122739. 4 interactions.
IntActiQ86V24. 1 interaction.
STRINGi9606.ENSP00000349616.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WXWX-ray2.40A100-368[»]
ProteinModelPortaliQ86V24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.1 Publication

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ86V24.
KOiK07297.
OMAiISEEHEC.
OrthoDBiEOG7BS49P.
PhylomeDBiQ86V24.
TreeFamiTF313640.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86V24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV
60 70 80 90 100
LSSHHKKSSE EHEYSDEAPQ EDEGFMGMSP LLQAHHAMEK MEEFVCKVWE
110 120 130 140 150
GRWRVIPHDV LPDWLKDNDF LLHGHRPPMP SFRACFKSIF RIHTETGNIW
160 170 180 190 200
THLLGCVFFL CLGIFYMFRP NISFVAPLQE KVVFGLFFLG AILCLSFSWL
210 220 230 240 250
FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY CNPQPCFIYL
260 270 280 290 300
IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFLGLGLSGI IPTLHYVISE
310 320 330 340 350
GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL
360 370 380
FHIFVVAGAF VHFHGVSNLQ EFRFMIGGGC SEEDAL
Length:386
Mass (Da):43,884
Last modified:June 1, 2003 - v1
Checksum:iB3B0FF0BBF118AA1
GO

Sequence cautioni

The sequence BAB15062.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581F → S in BAB15062 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391Q → R.
Corresponds to variant rs12298275 [ dbSNP | Ensembl ].
VAR_048203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424280 mRNA. Translation: AAR08368.1.
AK025085 mRNA. Translation: BAB15062.1. Different initiation.
AK127196 mRNA. Translation: BAC86881.1.
AK128511 mRNA. Translation: BAC87473.1.
CH471116 Genomic DNA. Translation: EAW88924.1.
BC051858 mRNA. Translation: AAH51858.1.
CCDSiCCDS8511.1.
RefSeqiNP_078827.2. NM_024551.2.
XP_005253846.1. XM_005253789.1.
XP_006719081.1. XM_006719018.1.
UniGeneiHs.371642.

Genome annotation databases

EnsembliENST00000357103; ENSP00000349616; ENSG00000006831.
GeneIDi79602.
KEGGihsa:79602.
UCSCiuc001qjm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Adiponectin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424280 mRNA. Translation: AAR08368.1.
AK025085 mRNA. Translation: BAB15062.1. Different initiation.
AK127196 mRNA. Translation: BAC86881.1.
AK128511 mRNA. Translation: BAC87473.1.
CH471116 Genomic DNA. Translation: EAW88924.1.
BC051858 mRNA. Translation: AAH51858.1.
CCDSiCCDS8511.1.
RefSeqiNP_078827.2. NM_024551.2.
XP_005253846.1. XM_005253789.1.
XP_006719081.1. XM_006719018.1.
UniGeneiHs.371642.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WXWX-ray2.40A100-368[»]
ProteinModelPortaliQ86V24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122739. 4 interactions.
IntActiQ86V24. 1 interaction.
STRINGi9606.ENSP00000349616.

Chemistry

GuidetoPHARMACOLOGYi650.

Polymorphism and mutation databases

BioMutaiADIPOR2.
DMDMi38372190.

Proteomic databases

MaxQBiQ86V24.
PaxDbiQ86V24.
PRIDEiQ86V24.

Protocols and materials databases

DNASUi79602.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357103; ENSP00000349616; ENSG00000006831.
GeneIDi79602.
KEGGihsa:79602.
UCSCiuc001qjm.3. human.

Organism-specific databases

CTDi79602.
GeneCardsiGC12P001801.
HGNCiHGNC:24041. ADIPOR2.
HPAiHPA043737.
MIMi607946. gene.
neXtProtiNX_Q86V24.
PharmGKBiPA128394711.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ86V24.
KOiK07297.
OMAiISEEHEC.
OrthoDBiEOG7BS49P.
PhylomeDBiQ86V24.
TreeFamiTF313640.

Miscellaneous databases

ChiTaRSiADIPOR2. human.
GeneWikiiADIPOR2.
GenomeRNAii79602.
NextBioi68634.
PROiQ86V24.
SOURCEiSearch...

Gene expression databases

BgeeiQ86V24.
CleanExiHS_ADIPOR2.
GenevisibleiQ86V24. HS.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Hippocampus and Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 100-386 IN COMPLEX WITH ZINC, FUNCTION, TOPOLOGY, SUBCELLULAR LOCATION, MUTAGENESIS OF HIS-202; ASP-219; HIS-348 AND HIS-352.

Entry informationi

Entry nameiADR2_HUMAN
AccessioniPrimary (citable) accession number: Q86V24
Secondary accession number(s): Q53YY5, Q9H737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: June 24, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.