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Q86V15

- CASZ1_HUMAN

UniProt

Q86V15 - CASZ1_HUMAN

Protein

Zinc finger protein castor homolog 1

Gene

CASZ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 4 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri551 – 57525C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri610 – 63425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri668 – 69225C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1031 – 105525C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1300 – 132425C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1457 – 148125C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1515 – 153723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1571 – 159525C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein castor homolog 1
    Alternative name(s):
    Castor-related protein
    Putative survival-related protein
    Zinc finger protein 693
    Gene namesi
    Name:CASZ1
    Synonyms:CST, SRG, ZNF693
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26002. CASZ1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. intracellular membrane-bounded organelle Source: HPA
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672203.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17591759Zinc finger protein castor homolog 1PRO_0000046912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei981 – 9811Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86V15.
    PaxDbiQ86V15.
    PRIDEiQ86V15.

    PTM databases

    PhosphoSiteiQ86V15.

    Expressioni

    Tissue specificityi

    Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain.1 Publication

    Gene expression databases

    ArrayExpressiQ86V15.
    BgeeiQ86V15.
    CleanExiHS_CASZ1.
    GenevestigatoriQ86V15.

    Organism-specific databases

    HPAiHPA028222.
    HPA029927.

    Interactioni

    Protein-protein interaction databases

    BioGridi120243. 3 interactions.
    IntActiQ86V15. 1 interaction.
    STRINGi9606.ENSP00000366221.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86V15.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi384 – 41734Pro-richAdd
    BLAST
    Compositional biasi1080 – 114364Pro-richAdd
    BLAST
    Compositional biasi1635 – 167036Ala-richAdd
    BLAST
    Compositional biasi1672 – 172958Glu-richAdd
    BLAST
    Compositional biasi1691 – 171828Asp-richAdd
    BLAST

    Sequence similaritiesi

    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri551 – 57525C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri610 – 63425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri668 – 69225C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1031 – 105525C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1300 – 132425C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1457 – 148125C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1515 – 153723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1571 – 159525C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG324200.
    HOVERGENiHBG080122.
    InParanoidiQ86V15.
    OMAiTAEGTRC.
    OrthoDBiEOG73NG37.
    PhylomeDBiQ86V15.
    TreeFamiTF324787.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 11 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86V15-1) [UniParc]FASTAAdd to Basket

    Also known as: hCASZ11

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLGTAEGTR CTDPPAGKPA MAPKRKGGLK LNAICAKLSR QVVVEKRADA     50
    GSHTEGSPSQ PRDQERSGPE SGAARAPRSE EDKRRAVIEK WVNGEYSEEP 100
    APTPVLGRIA REGLELPPEG VYMVQPQGCS DEEDHAEEPS KDGGALEEKD 150
    SDGAASKEDS GPSTRQASGE ASSLRDYAAS TMTEFLGMFG YDDQNTRDEL 200
    ARKISFEKLH AGSTPEAATS SMLPTSEDTL SKRARFSKYE EYIRKLKAGE 250
    QLSWPAPSTK TEERVGKEVV GTLPGLRLPS STAHLETKAT ILPLPSHSSV 300
    QMQNLVARAS KYDFFIQKLK TGENLRPQNG STYKKPSKYD LENVKYLHLF 350
    KPGEGSPDMG GAIAFKTGKV GRPSKYDVRG IQKPGPAKVP PTPSLAPAPL 400
    ASVPSAPSAP GPGPEPPASL SFNTPEYLKS TFSKTDSITT GTVSTVKNGL 450
    PTDKPAVTED VNIYQKYIAR FSGSQHCGHI HCAYQYREHY HCLDPECNYQ 500
    RFTSKQDVIR HYNMHKKRDN SLQHGFMRFS PLDDCSVYYH GCHLNGKSTH 550
    YHCMQVGCNK VYTSTSDVMT HENFHKKNTQ LINDGFQRFR ATEDCGTADC 600
    QFYGQKTTHF HCRRPGCTFT FKNKCDIEKH KSYHIKDDAY AKDGFKKFYK 650
    YEECKYEGCV YSKATNHFHC IRAGCGFTFT STSQMTSHKR KHERRHIRSS 700
    GALGLPPSLL GAKDTEHEES SNDDLVDFSA LSSKNSSLSA SPTSQQSSAS 750
    LAAATAATEA GPSATKPPNS KISGLLPQGL PGSIPLALAL SNSGLPTPTP 800
    YFPILAGRGS TSLPVGTPSL LGAVSSGSAA SATPDTPTLV ASGAGDSAPV 850
    AAASVPAPPA SIMERISASK GLISPMMARL AAAALKPSAT FDPGSGQQVT 900
    PARFPPAQVK PEPGESTGAP GPHEASQDRS LDLTVKEPSN ESNGHAVPAN 950
    SSLLSSLMNK MSQGNPGLGS LLNIKAEAEG SPAAEPSPFL GKAVKALVQE 1000
    KLAEPWKVYL RRFGTKDFCD GQCDFLHKAH FHCVVEECGA LFSTLDGAIK 1050
    HANFHFRTEG GAAKGNTEAA FPASAAETKP PMAPSSPPVP PVTTATVSSL 1100
    EGPAPSPASV PSTPTLLAWK QLASTIPQMP QIPASVPHLP ASPLATTSLE 1150
    NAKPQVKPGF LQFQENDPCL ATDCKYANKF HFHCLFGNCK YVCKTSGKAE 1200
    SHCLDHINPN NNLVNVRDQF AYYSLQCLCP NQHCEFRMRG HYHCLRTGCY 1250
    FVTNITTKLP WHIKKHEKAE RRAANGFKYF TKREECGRLG CKYNQVNSHF 1300
    HCIREGCQFS FLLKHQMTSH ARKHMRRMLG KNFDRVPPSQ GPPGLMDAET 1350
    DECMDYTGCS PGAMSSESST MDRSCSSTPV GNESTAAGNT ISMPTASGAK 1400
    KRFWIIEDMS PFGKRRKTAS SRKMLDEGMM LEGFRRFDLY EDCKDAACQF 1450
    SLKVTHYHCT RENCGYKFCG RTHMYKHAQH HDRVDNLVLD DFKRFKASLS 1500
    CHFADCPFSG TSTHFHCLRC RFRCTDSTKV TAHRKHHGKQ DVISAAGFCQ 1550
    FSSSADCAVP DCKYKLKCSH FHCTFPGCRH TVVGMSQMDS HKRKHEKQER 1600
    GEPAAEGPAP GPPISLDGSL SLGAEPGSLL FLQSAAAGLG LALGDAGDPG 1650
    PPDAAAPGPR EGAAAAAAAA GESSQEDEEE ELELPEEEAE DDEDEDDDED 1700
    DDDEDDDEDD DDEDLRTDSE ESLPEAAAEA AGAGARTPAL AALAALGAPG 1750
    PAPTAASSP 1759
    Length:1,759
    Mass (Da):190,069
    Last modified:July 13, 2010 - v4
    Checksum:i4F5146BE72606654
    GO
    Isoform 2 (identifier: Q86V15-2) [UniParc]FASTAAdd to Basket

    Also known as: hCASZ5

    The sequence of this isoform differs from the canonical sequence as follows:
         1166-1166: N → K
         1167-1759: Missing.

    Show »
    Length:1,166
    Mass (Da):124,788
    Checksum:i920E46461E4BC1A5
    GO

    Sequence cautioni

    The sequence BAA91089.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921D → N in ABB29845. (PubMed:16631614)Curated
    Sequence conflicti273 – 2731L → P in ABB29845. (PubMed:16631614)Curated
    Sequence conflicti408 – 4081S → N in BAA91089. (PubMed:15489334)Curated
    Sequence conflicti486 – 4861Y → H in ABB29845. (PubMed:16631614)Curated
    Sequence conflicti650 – 6501K → E in ABB29845. (PubMed:16631614)Curated
    Sequence conflicti813 – 8131L → P in AAH51883. (PubMed:16710414)Curated
    Sequence conflicti961 – 9611M → T in ABB29845. (PubMed:16631614)Curated
    Sequence conflicti989 – 9891F → S in ABB29845. (PubMed:16631614)Curated
    Sequence conflicti1061 – 10611G → E in BAA91089. (PubMed:15489334)Curated
    Sequence conflicti1297 – 12971N → S in ABB29845. (PubMed:16631614)Curated
    Sequence conflicti1501 – 15011C → R in ABB29845. (PubMed:16631614)Curated
    Sequence conflicti1549 – 15491C → R in ABB29845. (PubMed:16631614)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1166 – 11661N → K in isoform 2. 2 PublicationsVSP_027093
    Alternative sequencei1167 – 1759593Missing in isoform 2. 2 PublicationsVSP_027094Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ372703 mRNA. Translation: ABD14411.1. Sequence problems.
    DQ217660 mRNA. Translation: ABB29845.1.
    AL139423 Genomic DNA. Translation: CAI22571.1.
    BC004410 mRNA. Translation: AAH04410.2.
    BC051883 mRNA. Translation: AAH51883.2.
    AK000328 mRNA. Translation: BAA91089.1. Different initiation.
    AK130996 mRNA. Translation: BAC85474.1. Sequence problems.
    CCDSiCCDS120.2. [Q86V15-2]
    CCDS41246.1. [Q86V15-1]
    RefSeqiNP_001073312.1. NM_001079843.2. [Q86V15-1]
    NP_060236.3. NM_017766.4. [Q86V15-2]
    XP_006710775.1. XM_006710712.1. [Q86V15-1]
    UniGeneiHs.439894.

    Genome annotation databases

    EnsembliENST00000344008; ENSP00000339445; ENSG00000130940. [Q86V15-2]
    ENST00000377022; ENSP00000366221; ENSG00000130940. [Q86V15-1]
    GeneIDi54897.
    KEGGihsa:54897.
    UCSCiuc001aro.4. human. [Q86V15-1]
    uc001arp.2. human. [Q86V15-2]

    Polymorphism databases

    DMDMi300669712.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ372703 mRNA. Translation: ABD14411.1 . Sequence problems.
    DQ217660 mRNA. Translation: ABB29845.1 .
    AL139423 Genomic DNA. Translation: CAI22571.1 .
    BC004410 mRNA. Translation: AAH04410.2 .
    BC051883 mRNA. Translation: AAH51883.2 .
    AK000328 mRNA. Translation: BAA91089.1 . Different initiation.
    AK130996 mRNA. Translation: BAC85474.1 . Sequence problems.
    CCDSi CCDS120.2. [Q86V15-2 ]
    CCDS41246.1. [Q86V15-1 ]
    RefSeqi NP_001073312.1. NM_001079843.2. [Q86V15-1 ]
    NP_060236.3. NM_017766.4. [Q86V15-2 ]
    XP_006710775.1. XM_006710712.1. [Q86V15-1 ]
    UniGenei Hs.439894.

    3D structure databases

    ProteinModelPortali Q86V15.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120243. 3 interactions.
    IntActi Q86V15. 1 interaction.
    STRINGi 9606.ENSP00000366221.

    PTM databases

    PhosphoSitei Q86V15.

    Polymorphism databases

    DMDMi 300669712.

    Proteomic databases

    MaxQBi Q86V15.
    PaxDbi Q86V15.
    PRIDEi Q86V15.

    Protocols and materials databases

    DNASUi 54897.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344008 ; ENSP00000339445 ; ENSG00000130940 . [Q86V15-2 ]
    ENST00000377022 ; ENSP00000366221 ; ENSG00000130940 . [Q86V15-1 ]
    GeneIDi 54897.
    KEGGi hsa:54897.
    UCSCi uc001aro.4. human. [Q86V15-1 ]
    uc001arp.2. human. [Q86V15-2 ]

    Organism-specific databases

    CTDi 54897.
    GeneCardsi GC01M010642.
    HGNCi HGNC:26002. CASZ1.
    HPAi HPA028222.
    HPA029927.
    MIMi 609895. gene.
    neXtProti NX_Q86V15.
    PharmGKBi PA142672203.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324200.
    HOVERGENi HBG080122.
    InParanoidi Q86V15.
    OMAi TAEGTRC.
    OrthoDBi EOG73NG37.
    PhylomeDBi Q86V15.
    TreeFami TF324787.

    Miscellaneous databases

    GeneWikii CASZ1.
    GenomeRNAii 54897.
    NextBioi 57910.
    PROi Q86V15.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86V15.
    Bgeei Q86V15.
    CleanExi HS_CASZ1.
    Genevestigatori Q86V15.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 11 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis."
      Yuan Z.-R., Wang R., Solomon J., Luo X., Sun H., Zhang L., Shi Y.
      Cancer Res. 65:10716-10724(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation."
      Liu Z., Yang X., Tan F., Cullion K., Thiele C.J.
      Biochem. Biophys. Res. Commun. 344:834-844(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Pancreas and Uterus.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 115-1759 (ISOFORM 2).
      Tissue: Hepatoma and Rectum.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-981, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway."
      Charpentier M.S., Christine K.S., Amin N.M., Dorr K.M., Kushner E.J., Bautch V.L., Taylor J.M., Conlon F.L.
      Dev. Cell 25:132-143(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MISCELLANEOUS.

    Entry informationi

    Entry nameiCASZ1_HUMAN
    AccessioniPrimary (citable) accession number: Q86V15
    Secondary accession number(s): Q078S9
    , Q2EN02, Q5T9S1, Q6ZNM8, Q8WX49, Q8WX50, Q9BT16, Q9NXC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 106 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Endothelial cells depleted in CASZ1 by siRNAs display dramatic alterations in adhesion, morphology and sprouting; normal behavior can be rescued by restoration of EGFL7 expression. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.

    Caution

    According to PubMed:16322216, another protein (SRG) is encoded on the 3'-UTR of the CASZ1 gene. The existence of this protein that may play a role in apoptosis is extremely dubious despite the fact it was localized in the cytoplasm with the help of a polyclonal antibody.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3