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Q86V15 (CASZ1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein castor homolog 1
Alternative name(s):
Castor-related protein
Putative survival-related protein
Zinc finger protein 693
Gene names
Name:CASZ1
Synonyms:CST, SRG, ZNF693
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1759 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcription factor By similarity.

Subcellular location

Nucleus Ref.2.

Tissue specificity

Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain. Ref.2

Sequence similarities

Contains 8 C2H2-type zinc fingers.

Caution

According to Ref.1, another protein (SRG) is encoded on the 3'-UTR of the CASZ1 gene. The existence of this protein that may play a role in apoptosis is extremely dubious despite the fact it was localized in the cytoplasm with the help of a polyclonal antibody.

Sequence caution

The sequence ABD14411.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

The sequence BAA91089.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC85474.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86V15-1)

Also known as: hCASZ11;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86V15-2)

Also known as: hCASZ5;

The sequence of this isoform differs from the canonical sequence as follows:
     1166-1166: N → K
     1167-1759: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17591759Zinc finger protein castor homolog 1
PRO_0000046912

Regions

Zinc finger551 – 57525C2H2-type 1
Zinc finger610 – 63425C2H2-type 2
Zinc finger668 – 69225C2H2-type 3
Zinc finger1031 – 105525C2H2-type 4
Zinc finger1300 – 132425C2H2-type 5
Zinc finger1457 – 148125C2H2-type 6
Zinc finger1515 – 153723C2H2-type 7
Zinc finger1571 – 159525C2H2-type 8
Compositional bias384 – 41734Pro-rich
Compositional bias1080 – 114364Pro-rich
Compositional bias1635 – 167036Ala-rich
Compositional bias1672 – 172958Glu-rich
Compositional bias1691 – 171828Asp-rich

Amino acid modifications

Modified residue9811Phosphoserine Ref.6

Natural variations

Alternative sequence11661N → K in isoform 2.
VSP_027093
Alternative sequence1167 – 1759593Missing in isoform 2.
VSP_027094

Experimental info

Sequence conflict1921D → N in ABB29845. Ref.2
Sequence conflict2731L → P in ABB29845. Ref.2
Sequence conflict4081S → N in BAA91089. Ref.4
Sequence conflict4861Y → H in ABB29845. Ref.2
Sequence conflict6501K → E in ABB29845. Ref.2
Sequence conflict8131L → P in AAH51883. Ref.3
Sequence conflict9611M → T in ABB29845. Ref.2
Sequence conflict9891F → S in ABB29845. Ref.2
Sequence conflict10611G → E in BAA91089. Ref.4
Sequence conflict12971N → S in ABB29845. Ref.2
Sequence conflict15011C → R in ABB29845. Ref.2
Sequence conflict15491C → R in ABB29845. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (hCASZ11) [UniParc].

Last modified July 13, 2010. Version 4.
Checksum: 4F5146BE72606654

FASTA1,759190,069
        10         20         30         40         50         60 
MDLGTAEGTR CTDPPAGKPA MAPKRKGGLK LNAICAKLSR QVVVEKRADA GSHTEGSPSQ 

        70         80         90        100        110        120 
PRDQERSGPE SGAARAPRSE EDKRRAVIEK WVNGEYSEEP APTPVLGRIA REGLELPPEG 

       130        140        150        160        170        180 
VYMVQPQGCS DEEDHAEEPS KDGGALEEKD SDGAASKEDS GPSTRQASGE ASSLRDYAAS 

       190        200        210        220        230        240 
TMTEFLGMFG YDDQNTRDEL ARKISFEKLH AGSTPEAATS SMLPTSEDTL SKRARFSKYE 

       250        260        270        280        290        300 
EYIRKLKAGE QLSWPAPSTK TEERVGKEVV GTLPGLRLPS STAHLETKAT ILPLPSHSSV 

       310        320        330        340        350        360 
QMQNLVARAS KYDFFIQKLK TGENLRPQNG STYKKPSKYD LENVKYLHLF KPGEGSPDMG 

       370        380        390        400        410        420 
GAIAFKTGKV GRPSKYDVRG IQKPGPAKVP PTPSLAPAPL ASVPSAPSAP GPGPEPPASL 

       430        440        450        460        470        480 
SFNTPEYLKS TFSKTDSITT GTVSTVKNGL PTDKPAVTED VNIYQKYIAR FSGSQHCGHI 

       490        500        510        520        530        540 
HCAYQYREHY HCLDPECNYQ RFTSKQDVIR HYNMHKKRDN SLQHGFMRFS PLDDCSVYYH 

       550        560        570        580        590        600 
GCHLNGKSTH YHCMQVGCNK VYTSTSDVMT HENFHKKNTQ LINDGFQRFR ATEDCGTADC 

       610        620        630        640        650        660 
QFYGQKTTHF HCRRPGCTFT FKNKCDIEKH KSYHIKDDAY AKDGFKKFYK YEECKYEGCV 

       670        680        690        700        710        720 
YSKATNHFHC IRAGCGFTFT STSQMTSHKR KHERRHIRSS GALGLPPSLL GAKDTEHEES 

       730        740        750        760        770        780 
SNDDLVDFSA LSSKNSSLSA SPTSQQSSAS LAAATAATEA GPSATKPPNS KISGLLPQGL 

       790        800        810        820        830        840 
PGSIPLALAL SNSGLPTPTP YFPILAGRGS TSLPVGTPSL LGAVSSGSAA SATPDTPTLV 

       850        860        870        880        890        900 
ASGAGDSAPV AAASVPAPPA SIMERISASK GLISPMMARL AAAALKPSAT FDPGSGQQVT 

       910        920        930        940        950        960 
PARFPPAQVK PEPGESTGAP GPHEASQDRS LDLTVKEPSN ESNGHAVPAN SSLLSSLMNK 

       970        980        990       1000       1010       1020 
MSQGNPGLGS LLNIKAEAEG SPAAEPSPFL GKAVKALVQE KLAEPWKVYL RRFGTKDFCD 

      1030       1040       1050       1060       1070       1080 
GQCDFLHKAH FHCVVEECGA LFSTLDGAIK HANFHFRTEG GAAKGNTEAA FPASAAETKP 

      1090       1100       1110       1120       1130       1140 
PMAPSSPPVP PVTTATVSSL EGPAPSPASV PSTPTLLAWK QLASTIPQMP QIPASVPHLP 

      1150       1160       1170       1180       1190       1200 
ASPLATTSLE NAKPQVKPGF LQFQENDPCL ATDCKYANKF HFHCLFGNCK YVCKTSGKAE 

      1210       1220       1230       1240       1250       1260 
SHCLDHINPN NNLVNVRDQF AYYSLQCLCP NQHCEFRMRG HYHCLRTGCY FVTNITTKLP 

      1270       1280       1290       1300       1310       1320 
WHIKKHEKAE RRAANGFKYF TKREECGRLG CKYNQVNSHF HCIREGCQFS FLLKHQMTSH 

      1330       1340       1350       1360       1370       1380 
ARKHMRRMLG KNFDRVPPSQ GPPGLMDAET DECMDYTGCS PGAMSSESST MDRSCSSTPV 

      1390       1400       1410       1420       1430       1440 
GNESTAAGNT ISMPTASGAK KRFWIIEDMS PFGKRRKTAS SRKMLDEGMM LEGFRRFDLY 

      1450       1460       1470       1480       1490       1500 
EDCKDAACQF SLKVTHYHCT RENCGYKFCG RTHMYKHAQH HDRVDNLVLD DFKRFKASLS 

      1510       1520       1530       1540       1550       1560 
CHFADCPFSG TSTHFHCLRC RFRCTDSTKV TAHRKHHGKQ DVISAAGFCQ FSSSADCAVP 

      1570       1580       1590       1600       1610       1620 
DCKYKLKCSH FHCTFPGCRH TVVGMSQMDS HKRKHEKQER GEPAAEGPAP GPPISLDGSL 

      1630       1640       1650       1660       1670       1680 
SLGAEPGSLL FLQSAAAGLG LALGDAGDPG PPDAAAPGPR EGAAAAAAAA GESSQEDEEE 

      1690       1700       1710       1720       1730       1740 
ELELPEEEAE DDEDEDDDED DDDEDDDEDD DDEDLRTDSE ESLPEAAAEA AGAGARTPAL 

      1750 
AALAALGAPG PAPTAASSP 

« Hide

Isoform 2 (hCASZ5) [UniParc].

Checksum: 920E46461E4BC1A5
Show »

FASTA1,166124,788

References

« Hide 'large scale' references
[1]"Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis."
Yuan Z.-R., Wang R., Solomon J., Luo X., Sun H., Zhang L., Shi Y.
Cancer Res. 65:10716-10724(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation."
Liu Z., Yang X., Tan F., Cullion K., Thiele C.J.
Biochem. Biophys. Res. Commun. 344:834-844(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Pancreas and Uterus.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 115-1759 (ISOFORM 2).
Tissue: Hepatoma and Rectum.
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-981, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ372703 mRNA. Translation: ABD14411.1. Sequence problems.
DQ217660 mRNA. Translation: ABB29845.1.
AL139423 Genomic DNA. Translation: CAI22571.1.
BC004410 mRNA. Translation: AAH04410.2.
BC051883 mRNA. Translation: AAH51883.2.
AK000328 mRNA. Translation: BAA91089.1. Different initiation.
AK130996 mRNA. Translation: BAC85474.1. Sequence problems.
RefSeqNP_001073312.1. NM_001079843.2.
NP_060236.3. NM_017766.4.
UniGeneHs.439894.

3D structure databases

ProteinModelPortalQ86V15.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120243. 2 interactions.
STRING9606.ENSP00000366221.

PTM databases

PhosphoSiteQ86V15.

Polymorphism databases

DMDM300669712.

Proteomic databases

PaxDbQ86V15.
PRIDEQ86V15.

Protocols and materials databases

DNASU54897.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344008; ENSP00000339445; ENSG00000130940. [Q86V15-2]
ENST00000377022; ENSP00000366221; ENSG00000130940. [Q86V15-1]
GeneID54897.
KEGGhsa:54897.
UCSCuc001aro.4. human. [Q86V15-1]
uc001arp.2. human. [Q86V15-2]

Organism-specific databases

CTD54897.
GeneCardsGC01M010642.
HGNCHGNC:26002. CASZ1.
HPAHPA028222.
HPA029927.
MIM609895. gene.
neXtProtNX_Q86V15.
PharmGKBPA142672203.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG324200.
HOVERGENHBG080122.
InParanoidQ86V15.
OMATAEGTRC.
OrthoDBEOG73NG37.
PhylomeDBQ86V15.
TreeFamTF324787.

Gene expression databases

ArrayExpressQ86V15.
BgeeQ86V15.
CleanExHS_CASZ1.
GenevestigatorQ86V15.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCASZ1.
GenomeRNAi54897.
NextBio57910.
PROQ86V15.
SOURCESearch...

Entry information

Entry nameCASZ1_HUMAN
AccessionPrimary (citable) accession number: Q86V15
Secondary accession number(s): Q078S9 expand/collapse secondary AC list , Q2EN02, Q5T9S1, Q6ZNM8, Q8WX49, Q8WX50, Q9BT16, Q9NXC6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 13, 2010
Last modified: April 16, 2014
This is version 102 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM