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Q86V15

- CASZ1_HUMAN

UniProt

Q86V15 - CASZ1_HUMAN

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Protein

Zinc finger protein castor homolog 1

Gene

CASZ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri551 – 57525C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri610 – 63425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri668 – 69225C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1031 – 105525C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1300 – 132425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1457 – 148125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1515 – 153723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1571 – 159525C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein castor homolog 1
Alternative name(s):
Castor-related protein
Putative survival-related protein
Zinc finger protein 693
Gene namesi
Name:CASZ1
Synonyms:CST, SRG, ZNF693
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26002. CASZ1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. intracellular membrane-bounded organelle Source: HPA
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17591759Zinc finger protein castor homolog 1PRO_0000046912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei981 – 9811Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86V15.
PaxDbiQ86V15.
PRIDEiQ86V15.

PTM databases

PhosphoSiteiQ86V15.

Expressioni

Tissue specificityi

Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain.1 Publication

Gene expression databases

BgeeiQ86V15.
CleanExiHS_CASZ1.
ExpressionAtlasiQ86V15. baseline and differential.
GenevestigatoriQ86V15.

Organism-specific databases

HPAiHPA028222.
HPA029927.

Interactioni

Protein-protein interaction databases

BioGridi120243. 3 interactions.
IntActiQ86V15. 1 interaction.
STRINGi9606.ENSP00000366221.

Structurei

3D structure databases

ProteinModelPortaliQ86V15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi384 – 41734Pro-richAdd
BLAST
Compositional biasi1080 – 114364Pro-richAdd
BLAST
Compositional biasi1635 – 167036Ala-richAdd
BLAST
Compositional biasi1672 – 172958Glu-richAdd
BLAST
Compositional biasi1691 – 171828Asp-richAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri551 – 57525C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri610 – 63425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri668 – 69225C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1031 – 105525C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1300 – 132425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1457 – 148125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1515 – 153723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1571 – 159525C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG324200.
GeneTreeiENSGT00390000008187.
HOVERGENiHBG080122.
InParanoidiQ86V15.
OMAiTAEGTRC.
OrthoDBiEOG73NG37.
PhylomeDBiQ86V15.
TreeFamiTF324787.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86V15-1) [UniParc]FASTAAdd to Basket

Also known as: hCASZ11

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLGTAEGTR CTDPPAGKPA MAPKRKGGLK LNAICAKLSR QVVVEKRADA
60 70 80 90 100
GSHTEGSPSQ PRDQERSGPE SGAARAPRSE EDKRRAVIEK WVNGEYSEEP
110 120 130 140 150
APTPVLGRIA REGLELPPEG VYMVQPQGCS DEEDHAEEPS KDGGALEEKD
160 170 180 190 200
SDGAASKEDS GPSTRQASGE ASSLRDYAAS TMTEFLGMFG YDDQNTRDEL
210 220 230 240 250
ARKISFEKLH AGSTPEAATS SMLPTSEDTL SKRARFSKYE EYIRKLKAGE
260 270 280 290 300
QLSWPAPSTK TEERVGKEVV GTLPGLRLPS STAHLETKAT ILPLPSHSSV
310 320 330 340 350
QMQNLVARAS KYDFFIQKLK TGENLRPQNG STYKKPSKYD LENVKYLHLF
360 370 380 390 400
KPGEGSPDMG GAIAFKTGKV GRPSKYDVRG IQKPGPAKVP PTPSLAPAPL
410 420 430 440 450
ASVPSAPSAP GPGPEPPASL SFNTPEYLKS TFSKTDSITT GTVSTVKNGL
460 470 480 490 500
PTDKPAVTED VNIYQKYIAR FSGSQHCGHI HCAYQYREHY HCLDPECNYQ
510 520 530 540 550
RFTSKQDVIR HYNMHKKRDN SLQHGFMRFS PLDDCSVYYH GCHLNGKSTH
560 570 580 590 600
YHCMQVGCNK VYTSTSDVMT HENFHKKNTQ LINDGFQRFR ATEDCGTADC
610 620 630 640 650
QFYGQKTTHF HCRRPGCTFT FKNKCDIEKH KSYHIKDDAY AKDGFKKFYK
660 670 680 690 700
YEECKYEGCV YSKATNHFHC IRAGCGFTFT STSQMTSHKR KHERRHIRSS
710 720 730 740 750
GALGLPPSLL GAKDTEHEES SNDDLVDFSA LSSKNSSLSA SPTSQQSSAS
760 770 780 790 800
LAAATAATEA GPSATKPPNS KISGLLPQGL PGSIPLALAL SNSGLPTPTP
810 820 830 840 850
YFPILAGRGS TSLPVGTPSL LGAVSSGSAA SATPDTPTLV ASGAGDSAPV
860 870 880 890 900
AAASVPAPPA SIMERISASK GLISPMMARL AAAALKPSAT FDPGSGQQVT
910 920 930 940 950
PARFPPAQVK PEPGESTGAP GPHEASQDRS LDLTVKEPSN ESNGHAVPAN
960 970 980 990 1000
SSLLSSLMNK MSQGNPGLGS LLNIKAEAEG SPAAEPSPFL GKAVKALVQE
1010 1020 1030 1040 1050
KLAEPWKVYL RRFGTKDFCD GQCDFLHKAH FHCVVEECGA LFSTLDGAIK
1060 1070 1080 1090 1100
HANFHFRTEG GAAKGNTEAA FPASAAETKP PMAPSSPPVP PVTTATVSSL
1110 1120 1130 1140 1150
EGPAPSPASV PSTPTLLAWK QLASTIPQMP QIPASVPHLP ASPLATTSLE
1160 1170 1180 1190 1200
NAKPQVKPGF LQFQENDPCL ATDCKYANKF HFHCLFGNCK YVCKTSGKAE
1210 1220 1230 1240 1250
SHCLDHINPN NNLVNVRDQF AYYSLQCLCP NQHCEFRMRG HYHCLRTGCY
1260 1270 1280 1290 1300
FVTNITTKLP WHIKKHEKAE RRAANGFKYF TKREECGRLG CKYNQVNSHF
1310 1320 1330 1340 1350
HCIREGCQFS FLLKHQMTSH ARKHMRRMLG KNFDRVPPSQ GPPGLMDAET
1360 1370 1380 1390 1400
DECMDYTGCS PGAMSSESST MDRSCSSTPV GNESTAAGNT ISMPTASGAK
1410 1420 1430 1440 1450
KRFWIIEDMS PFGKRRKTAS SRKMLDEGMM LEGFRRFDLY EDCKDAACQF
1460 1470 1480 1490 1500
SLKVTHYHCT RENCGYKFCG RTHMYKHAQH HDRVDNLVLD DFKRFKASLS
1510 1520 1530 1540 1550
CHFADCPFSG TSTHFHCLRC RFRCTDSTKV TAHRKHHGKQ DVISAAGFCQ
1560 1570 1580 1590 1600
FSSSADCAVP DCKYKLKCSH FHCTFPGCRH TVVGMSQMDS HKRKHEKQER
1610 1620 1630 1640 1650
GEPAAEGPAP GPPISLDGSL SLGAEPGSLL FLQSAAAGLG LALGDAGDPG
1660 1670 1680 1690 1700
PPDAAAPGPR EGAAAAAAAA GESSQEDEEE ELELPEEEAE DDEDEDDDED
1710 1720 1730 1740 1750
DDDEDDDEDD DDEDLRTDSE ESLPEAAAEA AGAGARTPAL AALAALGAPG

PAPTAASSP
Length:1,759
Mass (Da):190,069
Last modified:July 13, 2010 - v4
Checksum:i4F5146BE72606654
GO
Isoform 2 (identifier: Q86V15-2) [UniParc]FASTAAdd to Basket

Also known as: hCASZ5

The sequence of this isoform differs from the canonical sequence as follows:
     1166-1166: N → K
     1167-1759: Missing.

Show »
Length:1,166
Mass (Da):124,788
Checksum:i920E46461E4BC1A5
GO

Sequence cautioni

The sequence BAA91089.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921D → N in ABB29845. (PubMed:16631614)Curated
Sequence conflicti273 – 2731L → P in ABB29845. (PubMed:16631614)Curated
Sequence conflicti408 – 4081S → N in BAA91089. (PubMed:15489334)Curated
Sequence conflicti486 – 4861Y → H in ABB29845. (PubMed:16631614)Curated
Sequence conflicti650 – 6501K → E in ABB29845. (PubMed:16631614)Curated
Sequence conflicti813 – 8131L → P in AAH51883. (PubMed:16710414)Curated
Sequence conflicti961 – 9611M → T in ABB29845. (PubMed:16631614)Curated
Sequence conflicti989 – 9891F → S in ABB29845. (PubMed:16631614)Curated
Sequence conflicti1061 – 10611G → E in BAA91089. (PubMed:15489334)Curated
Sequence conflicti1297 – 12971N → S in ABB29845. (PubMed:16631614)Curated
Sequence conflicti1501 – 15011C → R in ABB29845. (PubMed:16631614)Curated
Sequence conflicti1549 – 15491C → R in ABB29845. (PubMed:16631614)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1166 – 11661N → K in isoform 2. 2 PublicationsVSP_027093
Alternative sequencei1167 – 1759593Missing in isoform 2. 2 PublicationsVSP_027094Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ372703 mRNA. Translation: ABD14411.1. Sequence problems.
DQ217660 mRNA. Translation: ABB29845.1.
AL139423 Genomic DNA. Translation: CAI22571.1.
BC004410 mRNA. Translation: AAH04410.2.
BC051883 mRNA. Translation: AAH51883.2.
AK000328 mRNA. Translation: BAA91089.1. Different initiation.
AK130996 mRNA. Translation: BAC85474.1. Sequence problems.
CCDSiCCDS120.2. [Q86V15-2]
CCDS41246.1. [Q86V15-1]
RefSeqiNP_001073312.1. NM_001079843.2. [Q86V15-1]
NP_060236.3. NM_017766.4. [Q86V15-2]
XP_006710775.1. XM_006710712.1. [Q86V15-1]
UniGeneiHs.439894.

Genome annotation databases

EnsembliENST00000344008; ENSP00000339445; ENSG00000130940. [Q86V15-2]
ENST00000377022; ENSP00000366221; ENSG00000130940. [Q86V15-1]
GeneIDi54897.
KEGGihsa:54897.
UCSCiuc001aro.4. human. [Q86V15-1]
uc001arp.2. human. [Q86V15-2]

Polymorphism databases

DMDMi300669712.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ372703 mRNA. Translation: ABD14411.1 . Sequence problems.
DQ217660 mRNA. Translation: ABB29845.1 .
AL139423 Genomic DNA. Translation: CAI22571.1 .
BC004410 mRNA. Translation: AAH04410.2 .
BC051883 mRNA. Translation: AAH51883.2 .
AK000328 mRNA. Translation: BAA91089.1 . Different initiation.
AK130996 mRNA. Translation: BAC85474.1 . Sequence problems.
CCDSi CCDS120.2. [Q86V15-2 ]
CCDS41246.1. [Q86V15-1 ]
RefSeqi NP_001073312.1. NM_001079843.2. [Q86V15-1 ]
NP_060236.3. NM_017766.4. [Q86V15-2 ]
XP_006710775.1. XM_006710712.1. [Q86V15-1 ]
UniGenei Hs.439894.

3D structure databases

ProteinModelPortali Q86V15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120243. 3 interactions.
IntActi Q86V15. 1 interaction.
STRINGi 9606.ENSP00000366221.

PTM databases

PhosphoSitei Q86V15.

Polymorphism databases

DMDMi 300669712.

Proteomic databases

MaxQBi Q86V15.
PaxDbi Q86V15.
PRIDEi Q86V15.

Protocols and materials databases

DNASUi 54897.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344008 ; ENSP00000339445 ; ENSG00000130940 . [Q86V15-2 ]
ENST00000377022 ; ENSP00000366221 ; ENSG00000130940 . [Q86V15-1 ]
GeneIDi 54897.
KEGGi hsa:54897.
UCSCi uc001aro.4. human. [Q86V15-1 ]
uc001arp.2. human. [Q86V15-2 ]

Organism-specific databases

CTDi 54897.
GeneCardsi GC01M010642.
HGNCi HGNC:26002. CASZ1.
HPAi HPA028222.
HPA029927.
MIMi 609895. gene.
neXtProti NX_Q86V15.
PharmGKBi PA142672203.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG324200.
GeneTreei ENSGT00390000008187.
HOVERGENi HBG080122.
InParanoidi Q86V15.
OMAi TAEGTRC.
OrthoDBi EOG73NG37.
PhylomeDBi Q86V15.
TreeFami TF324787.

Miscellaneous databases

GeneWikii CASZ1.
GenomeRNAii 54897.
NextBioi 57910.
PROi Q86V15.
SOURCEi Search...

Gene expression databases

Bgeei Q86V15.
CleanExi HS_CASZ1.
ExpressionAtlasi Q86V15. baseline and differential.
Genevestigatori Q86V15.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 11 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis."
    Yuan Z.-R., Wang R., Solomon J., Luo X., Sun H., Zhang L., Shi Y.
    Cancer Res. 65:10716-10724(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation."
    Liu Z., Yang X., Tan F., Cullion K., Thiele C.J.
    Biochem. Biophys. Res. Commun. 344:834-844(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Pancreas and Uterus.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 115-1759 (ISOFORM 2).
    Tissue: Hepatoma and Rectum.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-981, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway."
    Charpentier M.S., Christine K.S., Amin N.M., Dorr K.M., Kushner E.J., Bautch V.L., Taylor J.M., Conlon F.L.
    Dev. Cell 25:132-143(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MISCELLANEOUS.

Entry informationi

Entry nameiCASZ1_HUMAN
AccessioniPrimary (citable) accession number: Q86V15
Secondary accession number(s): Q078S9
, Q2EN02, Q5T9S1, Q6ZNM8, Q8WX49, Q8WX50, Q9BT16, Q9NXC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Endothelial cells depleted in CASZ1 by siRNAs display dramatic alterations in adhesion, morphology and sprouting; normal behavior can be rescued by restoration of EGFL7 expression. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.

Caution

According to PubMed:16322216, another protein (SRG) is encoded on the 3'-UTR of the CASZ1 gene. The existence of this protein that may play a role in apoptosis is extremely dubious despite the fact it was localized in the cytoplasm with the help of a polyclonal antibody.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3