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Protein
Submitted name:

FZD2 protein

Gene

FZD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation, ReceptorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
FZD2 proteinImported
Gene namesi
Name:FZD2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei322 – 344HelicalSequence analysisAdd BLAST23
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Transmembranei405 – 430HelicalSequence analysisAdd BLAST26
Transmembranei489 – 515HelicalSequence analysisAdd BLAST27
Transmembranei536 – 559HelicalSequence analysisAdd BLAST24
Transmembranei594 – 616HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi115 ↔ 176PROSITE-ProRule annotation
Disulfide bondi123 ↔ 169PROSITE-ProRule annotation
Disulfide bondi190 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiQ86UZ8
PRIDEiQ86UZ8

Expressioni

Gene expression databases

GenevisibleiQ86UZ8 HS

Structurei

3D structure databases

ProteinModelPortaliQ86UZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 229FZInterPro annotationAdd BLAST120
Domaini320 – 623G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST304

Sequence similaritiesi

Belongs to the G-protein coupled receptor Fz/Smo family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
HOGENOMiHOG000233237
HOVERGENiHBG006977
KOiK02235
PhylomeDBiQ86UZ8

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR026550 FZD2
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF34 PTHR11309:SF34, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Fragment.

Q86UZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ARGVSGCSVR PRQASGQAHR PLPRPASPTL RPRVKFAKRR GRRQPQRGGG
60 70 80 90 100
GEEAQSPGWG RGRGGRQGAG WGAAASMRPR SALPRLLLPL LLLPAAGPAQ
110 120 130 140 150
FHGEKGISIP DHGFCQPISI PLCTDIAYNQ TIMPNLLGHT NQEDAGLEVH
160 170 180 190 200
QFYPLVKVQC SPELRFFLCS MYAPVCTVLE QAIPPCRSIC ERARQGCEAL
210 220 230 240 250
MNKFGFQWPE RLRCEHFPRH GAEQICVGQN HSEDGAPALL TTAPPPGLQP
260 270 280 290 300
GAGGTPGGPG GGGAPPRYAT LEHPFHCPRV LKVPSYLSYK FLGERDCAAP
310 320 330 340 350
CEPARPDGSM FFSQEETRFA RLWILTWSVL CCASTFFTVT TYLVDMQRFR
360 370 380 390 400
YPERPIIFLS GCYTMVSVAY IAGFVLQERV VCNERFSEDG YRTVVQGTKK
410 420 430 440 450
EGCTILFMML YFFSMASSIW WVILSLTWFL AAGMKWGHEA IEANSQYFHL
460 470 480 490 500
AAWAVPAVKT ITILAMGQID GDLLSGVCFV GLNSLDPLRG FVLAPLFVYL
510 520 530 540 550
FIGTSFLLAG FVSLFRIRTI MKHDGTKTEK LERLMVRIGV FSVLYTVPAT
560 570 580 590 600
IVIACYFYEQ AFREHWERSW VSQHCKSLAI PCPAHYTPRM SPDFTVYMIK
610 620 630 640
YLMTLIVGIT SGFWIWSGKT LHSWRKFYTR LTNSRHGETT V
Length:641
Mass (Da):71,488
Last modified:June 1, 2003 - v1
Checksum:i120BCF98F673DA29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052266 mRNA Translation: AAH52266.1
RefSeqiNP_001457.1, NM_001466.3
UniGeneiHs.142912
Hs.732654

Genome annotation databases

GeneIDi2535
KEGGihsa:2535

Similar proteinsi

Entry informationi

Entry nameiQ86UZ8_HUMAN
AccessioniPrimary (citable) accession number: Q86UZ8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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