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Protein
Submitted name:

FZD2 protein

Gene

FZD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation, ReceptorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
FZD2 proteinImported
Gene namesi
Name:FZD2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei322 – 344HelicalSequence analysisAdd BLAST23
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Transmembranei405 – 430HelicalSequence analysisAdd BLAST26
Transmembranei489 – 515HelicalSequence analysisAdd BLAST27
Transmembranei536 – 559HelicalSequence analysisAdd BLAST24
Transmembranei594 – 616HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi115 ↔ 176PROSITE-ProRule annotation
Disulfide bondi123 ↔ 169PROSITE-ProRule annotation
Disulfide bondi190 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiQ86UZ8.
PaxDbiQ86UZ8.
PRIDEiQ86UZ8.

Expressioni

Gene expression databases

BgeeiENSG00000180340.
GenevisibleiQ86UZ8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323901.

Structurei

3D structure databases

ProteinModelPortaliQ86UZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 229FZ (frizzled)InterPro annotationAdd BLAST120
Domaini320 – 623G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST304

Sequence similaritiesi

Belongs to the G-protein coupled receptor Fz/Smo family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
KOiK02235.
PhylomeDBiQ86UZ8.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026550. FZD2.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF103. PTHR11309:SF103. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q86UZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ARGVSGCSVR PRQASGQAHR PLPRPASPTL RPRVKFAKRR GRRQPQRGGG
60 70 80 90 100
GEEAQSPGWG RGRGGRQGAG WGAAASMRPR SALPRLLLPL LLLPAAGPAQ
110 120 130 140 150
FHGEKGISIP DHGFCQPISI PLCTDIAYNQ TIMPNLLGHT NQEDAGLEVH
160 170 180 190 200
QFYPLVKVQC SPELRFFLCS MYAPVCTVLE QAIPPCRSIC ERARQGCEAL
210 220 230 240 250
MNKFGFQWPE RLRCEHFPRH GAEQICVGQN HSEDGAPALL TTAPPPGLQP
260 270 280 290 300
GAGGTPGGPG GGGAPPRYAT LEHPFHCPRV LKVPSYLSYK FLGERDCAAP
310 320 330 340 350
CEPARPDGSM FFSQEETRFA RLWILTWSVL CCASTFFTVT TYLVDMQRFR
360 370 380 390 400
YPERPIIFLS GCYTMVSVAY IAGFVLQERV VCNERFSEDG YRTVVQGTKK
410 420 430 440 450
EGCTILFMML YFFSMASSIW WVILSLTWFL AAGMKWGHEA IEANSQYFHL
460 470 480 490 500
AAWAVPAVKT ITILAMGQID GDLLSGVCFV GLNSLDPLRG FVLAPLFVYL
510 520 530 540 550
FIGTSFLLAG FVSLFRIRTI MKHDGTKTEK LERLMVRIGV FSVLYTVPAT
560 570 580 590 600
IVIACYFYEQ AFREHWERSW VSQHCKSLAI PCPAHYTPRM SPDFTVYMIK
610 620 630 640
YLMTLIVGIT SGFWIWSGKT LHSWRKFYTR LTNSRHGETT V
Length:641
Mass (Da):71,488
Last modified:June 1, 2003 - v1
Checksum:i120BCF98F673DA29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052266 mRNA. Translation: AAH52266.1.
RefSeqiNP_001457.1. NM_001466.3.
UniGeneiHs.142912.
Hs.732654.

Genome annotation databases

GeneIDi2535.
KEGGihsa:2535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052266 mRNA. Translation: AAH52266.1.
RefSeqiNP_001457.1. NM_001466.3.
UniGeneiHs.142912.
Hs.732654.

3D structure databases

ProteinModelPortaliQ86UZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323901.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

MaxQBiQ86UZ8.
PaxDbiQ86UZ8.
PRIDEiQ86UZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2535.
KEGGihsa:2535.

Organism-specific databases

CTDi2535.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
KOiK02235.
PhylomeDBiQ86UZ8.

Miscellaneous databases

ChiTaRSiFZD2. human.
GenomeRNAii2535.

Gene expression databases

BgeeiENSG00000180340.
GenevisibleiQ86UZ8. HS.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026550. FZD2.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF103. PTHR11309:SF103. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ86UZ8_HUMAN
AccessioniPrimary (citable) accession number: Q86UZ8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 10, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.