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Protein

Zinc finger and BTB domain-containing protein 46

Gene

ZBTB46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Function as a transcriptional repressor for PRDM1.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri418 – 43619C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 46
Alternative name(s):
BTB-ZF protein expressed in effector lymphocytes
Short name:
BZEL
BTB/POZ domain-containing protein 4
Zinc finger protein 340
Gene namesi
Name:ZBTB46
Synonyms:BTBD4, ZNF340
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16094. ZBTB46.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25441.

Polymorphism and mutation databases

BioMutaiZBTB46.
DMDMi42558860.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Zinc finger and BTB domain-containing protein 46PRO_0000047746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki46 – 46Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki229 – 229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei234 – 2341PhosphoserineCombined sources

Post-translational modificationi

Sumoylated. Desumoylation by PPPDE2 reverses transcriptional repression activity (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ86UZ6.
MaxQBiQ86UZ6.
PaxDbiQ86UZ6.
PeptideAtlasiQ86UZ6.
PRIDEiQ86UZ6.

PTM databases

iPTMnetiQ86UZ6.
PhosphoSiteiQ86UZ6.

Expressioni

Gene expression databases

BgeeiQ86UZ6.
CleanExiHS_ZBTB46.
GenevisibleiQ86UZ6. HS.

Organism-specific databases

HPAiHPA013997.

Interactioni

Protein-protein interaction databases

BioGridi126648. 23 interactions.
STRINGi9606.ENSP00000245663.

Structurei

3D structure databases

ProteinModelPortaliQ86UZ6.
SMRiQ86UZ6. Positions 9-164, 352-379, 403-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9969BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri418 – 43619C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129682.
HOVERGENiHBG079368.
InParanoidiQ86UZ6.
KOiK10517.
OMAiTSGWPFS.
OrthoDBiEOG7KWSH5.
PhylomeDBiQ86UZ6.
TreeFamiTF341953.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86UZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL
60 70 80 90 100
GSSRYFKTLY CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR
110 120 130 140 150
NVIEVMSAAS FLQMTDIVQA CHDFIKAALD ISIKSDASDE LAEFEIGASS
160 170 180 190 200
SSSTEALISA VMAGRSISPW LARRTSPANS SGDSAIASCH DGGSSYGKED
210 220 230 240 250
QEPKADGPDD VSSQPLWPGD VGYGPLRIKE EQVSPSQYGG SELPSAKDGA
260 270 280 290 300
VQNSFSEQSA GDAWQPTGRR KNRKNKETVR HITQQVEDDS RASSPVPSFL
310 320 330 340 350
PTSGWPFSSR DSNADLSVTE ASSSDSRGER AELYAQVEEG LLGGEASYLG
360 370 380 390 400
PPLTPEKDDA LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP
410 420 430 440 450
RGAHSLSLNE FTVIRKKFKC PYCSFSAMHQ CILKRHMRSH TGERPYPCEI
460 470 480 490 500
CGKKFTRREH MKRHTLVHSK DKKYVCKVCS RVFMSAASVG IRHGSRRHGV
510 520 530 540 550
CTDCAGRGMA GPLDHGGGGG EGSPEALFPG DGPYLEDPED PRGEAEELGE
560 570 580
DDEGLAPEDA LLADDKDEED SPRPRSPPGG PDKDFAWLS
Length:589
Mass (Da):64,083
Last modified:February 16, 2004 - v2
Checksum:iF03FC7D7BF9B9E09
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111T → A.1 Publication
Corresponds to variant rs2281929 [ dbSNP | Ensembl ].
VAR_030629

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121845 Genomic DNA. Translation: CAI21885.1.
CH471077 Genomic DNA. Translation: EAW75205.1.
CH471077 Genomic DNA. Translation: EAW75206.1.
BC052269 mRNA. Translation: AAH52269.1.
BC073800 mRNA. Translation: AAH73800.1.
CCDSiCCDS13538.1.
RefSeqiNP_079500.2. NM_025224.3.
XP_005260252.1. XM_005260195.3.
XP_005260253.1. XM_005260196.2.
XP_005260254.1. XM_005260197.3.
XP_005260255.1. XM_005260198.3.
XP_006723763.1. XM_006723700.2.
XP_011526850.1. XM_011528548.1.
UniGeneiHs.585028.

Genome annotation databases

EnsembliENST00000245663; ENSP00000245663; ENSG00000130584.
ENST00000302995; ENSP00000303102; ENSG00000130584.
ENST00000395104; ENSP00000378536; ENSG00000130584.
GeneIDi140685.
KEGGihsa:140685.
UCSCiuc061ypq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121845 Genomic DNA. Translation: CAI21885.1.
CH471077 Genomic DNA. Translation: EAW75205.1.
CH471077 Genomic DNA. Translation: EAW75206.1.
BC052269 mRNA. Translation: AAH52269.1.
BC073800 mRNA. Translation: AAH73800.1.
CCDSiCCDS13538.1.
RefSeqiNP_079500.2. NM_025224.3.
XP_005260252.1. XM_005260195.3.
XP_005260253.1. XM_005260196.2.
XP_005260254.1. XM_005260197.3.
XP_005260255.1. XM_005260198.3.
XP_006723763.1. XM_006723700.2.
XP_011526850.1. XM_011528548.1.
UniGeneiHs.585028.

3D structure databases

ProteinModelPortaliQ86UZ6.
SMRiQ86UZ6. Positions 9-164, 352-379, 403-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126648. 23 interactions.
STRINGi9606.ENSP00000245663.

PTM databases

iPTMnetiQ86UZ6.
PhosphoSiteiQ86UZ6.

Polymorphism and mutation databases

BioMutaiZBTB46.
DMDMi42558860.

Proteomic databases

EPDiQ86UZ6.
MaxQBiQ86UZ6.
PaxDbiQ86UZ6.
PeptideAtlasiQ86UZ6.
PRIDEiQ86UZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245663; ENSP00000245663; ENSG00000130584.
ENST00000302995; ENSP00000303102; ENSG00000130584.
ENST00000395104; ENSP00000378536; ENSG00000130584.
GeneIDi140685.
KEGGihsa:140685.
UCSCiuc061ypq.1. human.

Organism-specific databases

CTDi140685.
GeneCardsiZBTB46.
HGNCiHGNC:16094. ZBTB46.
HPAiHPA013997.
MIMi614639. gene.
neXtProtiNX_Q86UZ6.
PharmGKBiPA25441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129682.
HOVERGENiHBG079368.
InParanoidiQ86UZ6.
KOiK10517.
OMAiTSGWPFS.
OrthoDBiEOG7KWSH5.
PhylomeDBiQ86UZ6.
TreeFamiTF341953.

Miscellaneous databases

ChiTaRSiZBTB46. human.
GenomeRNAii140685.
PROiQ86UZ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UZ6.
CleanExiHS_ZBTB46.
GenevisibleiQ86UZ6. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-11.
    Tissue: Prostate.
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  5. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-229, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZBT46_HUMAN
AccessioniPrimary (citable) accession number: Q86UZ6
Secondary accession number(s): E1P5K9
, Q5JWJ3, Q6GMV4, Q9BQK3, Q9H3Z8, Q9H3Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: July 6, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.