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Protein

Zinc finger and BTB domain-containing protein 46

Gene

ZBTB46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Function as a transcriptional repressor for PRDM1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri418 – 436C2H2-type 1PROSITE-ProRule annotationAdd BLAST19
Zinc fingeri446 – 468C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 46
Alternative name(s):
BTB-ZF protein expressed in effector lymphocytes
Short name:
BZEL
BTB/POZ domain-containing protein 4
Zinc finger protein 340
Gene namesi
Name:ZBTB46
Synonyms:BTBD4, ZNF340
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000130584.10
HGNCiHGNC:16094 ZBTB46
MIMi614639 gene
neXtProtiNX_Q86UZ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi140685
OpenTargetsiENSG00000130584
PharmGKBiPA25441

Polymorphism and mutation databases

BioMutaiZBTB46
DMDMi42558860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477461 – 589Zinc finger and BTB domain-containing protein 46Add BLAST589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei234PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated. Desumoylation by PPPDE2 reverses transcriptional repression activity (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ86UZ6
MaxQBiQ86UZ6
PaxDbiQ86UZ6
PeptideAtlasiQ86UZ6
PRIDEiQ86UZ6
ProteomicsDBi69942

PTM databases

iPTMnetiQ86UZ6
PhosphoSitePlusiQ86UZ6

Expressioni

Gene expression databases

BgeeiENSG00000130584
CleanExiHS_ZBTB46
GenevisibleiQ86UZ6 HS

Organism-specific databases

HPAiHPA013997

Interactioni

Protein-protein interaction databases

BioGridi126648, 26 interactors
STRINGi9606.ENSP00000245663

Structurei

3D structure databases

ProteinModelPortaliQ86UZ6
SMRiQ86UZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 99BTBPROSITE-ProRule annotationAdd BLAST69

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri418 – 436C2H2-type 1PROSITE-ProRule annotationAdd BLAST19
Zinc fingeri446 – 468C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148950
HOVERGENiHBG079368
InParanoidiQ86UZ6
KOiK10517
OMAiPTSGWPF
OrthoDBiEOG091G05WK
PhylomeDBiQ86UZ6
TreeFamiTF341953

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q86UZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL
60 70 80 90 100
GSSRYFKTLY CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR
110 120 130 140 150
NVIEVMSAAS FLQMTDIVQA CHDFIKAALD ISIKSDASDE LAEFEIGASS
160 170 180 190 200
SSSTEALISA VMAGRSISPW LARRTSPANS SGDSAIASCH DGGSSYGKED
210 220 230 240 250
QEPKADGPDD VSSQPLWPGD VGYGPLRIKE EQVSPSQYGG SELPSAKDGA
260 270 280 290 300
VQNSFSEQSA GDAWQPTGRR KNRKNKETVR HITQQVEDDS RASSPVPSFL
310 320 330 340 350
PTSGWPFSSR DSNADLSVTE ASSSDSRGER AELYAQVEEG LLGGEASYLG
360 370 380 390 400
PPLTPEKDDA LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP
410 420 430 440 450
RGAHSLSLNE FTVIRKKFKC PYCSFSAMHQ CILKRHMRSH TGERPYPCEI
460 470 480 490 500
CGKKFTRREH MKRHTLVHSK DKKYVCKVCS RVFMSAASVG IRHGSRRHGV
510 520 530 540 550
CTDCAGRGMA GPLDHGGGGG EGSPEALFPG DGPYLEDPED PRGEAEELGE
560 570 580
DDEGLAPEDA LLADDKDEED SPRPRSPPGG PDKDFAWLS
Length:589
Mass (Da):64,083
Last modified:February 16, 2004 - v2
Checksum:iF03FC7D7BF9B9E09
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03062911T → A1 PublicationCorresponds to variant dbSNP:rs2281929Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121845 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75205.1
CH471077 Genomic DNA Translation: EAW75206.1
BC052269 mRNA Translation: AAH52269.1
BC073800 mRNA Translation: AAH73800.1
CCDSiCCDS13538.1
RefSeqiNP_079500.2, NM_025224.3
XP_005260252.1, XM_005260195.4
XP_005260253.1, XM_005260196.3
XP_005260254.1, XM_005260197.4
XP_005260255.1, XM_005260198.4
XP_006723763.1, XM_006723700.3
XP_011526850.1, XM_011528548.2
UniGeneiHs.585028

Genome annotation databases

EnsembliENST00000245663; ENSP00000245663; ENSG00000130584
ENST00000302995; ENSP00000303102; ENSG00000130584
ENST00000395104; ENSP00000378536; ENSG00000130584
GeneIDi140685
KEGGihsa:140685
UCSCiuc061ypq.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBT46_HUMAN
AccessioniPrimary (citable) accession number: Q86UZ6
Secondary accession number(s): E1P5K9
, Q5JWJ3, Q6GMV4, Q9BQK3, Q9H3Z8, Q9H3Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: June 20, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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