CD44

Functionⁱ

GO - Molecular functionⁱ

hyaluronic acid binding Source: InterPro

GO - Biological processⁱ

cell adhesion Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: CD44 antigenImported Submitted name: CD44 proteinImported
Gene namesⁱ	Name:CD44Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

HGNCⁱ

HGNC:1681. CD44.

Subcellular locationⁱ

GO - Cellular componentⁱ

integral component of membrane Source: InterPro

Complete GO annotation...

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000026508.

OpenTargetsⁱ

ENSG00000026508.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_5010145612	21 – 80	Sequence analysisAdd BLAST		60

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86UZ1.

MaxQBⁱ

Q86UZ1.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000026508.
ExpressionAtlasⁱ	Q86UZ1. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	Q86UZ1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	32 – 80	LinkInterPro annotationAdd BLAST		49

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IZCP. Eukaryota. ENOG4111S6T. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063822.

Family and domain databases

Gene3Dⁱ	3.10.100.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016186. C-type_lectin-like/link. IPR001231. CD44_antigen. IPR016187. CTDL_fold. IPR000538. Link_dom.
PANTHERⁱ	PTHR10225:SF8. PTHR10225:SF8. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00193. Xlink. 1 hit.
PRINTSⁱ	PR00658. CD44.
SMARTⁱ	View protein in SMART SM00445. LINK. 1 hit.
SUPFAMⁱ	SSF56436. SSF56436. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50963. LINK_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q86UZ1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA 
        60         70         80
DLCKAFNSTL PTMAQMEKAL SIGFETCSST

Length:80

Mass (Da):8,931

Last modified:June 1, 2003 - v1

Checksum:ⁱB0AC664418A5EB56

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL133330 Genomic DNA. No translation available. AL136989 Genomic DNA. No translation available. AL356215 Genomic DNA. No translation available. BC052287 mRNA. Translation: AAH52287.1.
UniGeneⁱ	Hs.502328.

Genome annotation databases

Ensemblⁱ	ENST00000425428; ENSP00000395953; ENSG00000026508.
UCSC genome browser More...UCSCⁱ	uc058ain.1. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL133330 Genomic DNA. No translation available. AL136989 Genomic DNA. No translation available. AL356215 Genomic DNA. No translation available. BC052287 mRNA. Translation: AAH52287.1.
UniGeneⁱ	Hs.502328.

3D structure databases

SMRⁱ	Q86UZ1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86UZ1.

MaxQBⁱ

Q86UZ1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000425428; ENSP00000395953; ENSG00000026508.
UCSC genome browser More...UCSCⁱ	uc058ain.1. human.

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1681. CD44.
Open Targets More...OpenTargetsⁱ	ENSG00000026508.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZCP. Eukaryota. ENOG4111S6T. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063822.

Miscellaneous databases

ChiTaRSⁱ	CD44. human.

ChiTaRSⁱ

CD44. human.

Gene expression databases

Bgeeⁱ	ENSG00000026508.
ExpressionAtlasⁱ	Q86UZ1. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.10.100.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016186. C-type_lectin-like/link. IPR001231. CD44_antigen. IPR016187. CTDL_fold. IPR000538. Link_dom.
PANTHERⁱ	PTHR10225:SF8. PTHR10225:SF8. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00193. Xlink. 1 hit.
PRINTSⁱ	PR00658. CD44.
SMARTⁱ	View protein in SMART SM00445. LINK. 1 hit.
SUPFAMⁱ	SSF56436. SSF56436. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50963. LINK_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q86UZ1_HUMAN
Accessionⁱ	Q86UZ1Primary (citable) accession number: Q86UZ1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 2003
	Last sequence update:	June 1, 2003
	Last modified:	July 5, 2017
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86UZ1 (Q86UZ1_HUMAN)

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CD44 antigen

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ