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Protein
Submitted name:

TXNDC5 protein

Gene

TXNDC5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
TXNDC5 proteinImported
Gene namesi
Name:TXNDC5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

EPDiQ86UY0.

Interactioni

Protein-protein interaction databases

IntActiQ86UY0. 21 interactions.
STRINGi9606.ENSP00000369081.

Structurei

3D structure databases

SMRiQ86UY0. Positions 17-98, 118-224, 251-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation
Contains 2 thioredoxin domains.UniRule annotation

Keywords - Domaini

Redox-active centerSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
HOVERGENiHBG058611.
PhylomeDBiQ86UY0.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86UY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSVDSNRG NRNEKRCGHC QRLQPTWNDL GDKYNSMEDA KVYVAKVDCT
60 70 80 90 100
AHSDVCSAQG VRGYPTLKLF KPGQEAVKYQ GPRDFQTLEN WMLQTLNEEP
110 120 130 140 150
VTPEPEVEPP SAPELKQGLY ELSASNFELH VAQGDHFIKF FAPWCGHCKA
160 170 180 190 200
LAPTWEQLAL GLEHSETVKI GKVDCTQHYE LCSGNQVRGY PTLLWFRDGK
210 220 230 240 250
KVDQYKGKRD LESLREYVES QLQRTETGAT ETVTPSEAPV LAAEPEADKG
260 270 280 290 300
TVLALTENNF DDTIAEGITF IKFYAPWCGH CKTLAPTWEE LSKKEFPGLA
310 320 330 340 350
GVKIAEVDCT AERNICSKYS VRGYPTLLLF RGGKKVSEHS GGRDLDSLHR
360
FVLSQAKDEL
Length:360
Mass (Da):40,369
Last modified:June 1, 2003 - v1
Checksum:i32A402B0D2E8D18A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052310 mRNA. Translation: AAH52310.1.
UniGeneiHs.150837.

Genome annotation databases

UCSCiuc063lrr.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052310 mRNA. Translation: AAH52310.1.
UniGeneiHs.150837.

3D structure databases

SMRiQ86UY0. Positions 17-98, 118-224, 251-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86UY0. 21 interactions.
STRINGi9606.ENSP00000369081.

Proteomic databases

EPDiQ86UY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc063lrr.1. human.

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
HOVERGENiHBG058611.
PhylomeDBiQ86UY0.

Miscellaneous databases

ChiTaRSiTXNDC5. human.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: OvaryImported.

Entry informationi

Entry nameiQ86UY0_HUMAN
AccessioniPrimary (citable) accession number: Q86UY0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.