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Protein
Submitted name:

Protein BLOC1S5-TXNDC5

Gene

TXNDC5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein BLOC1S5-TXNDC5Imported
Submitted name:
TXNDC5 proteinImported
Gene namesi
Name:TXNDC5Imported
Synonyms:BLOC1S5-TXNDC5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:42001. BLOC1S5-TXNDC5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

ExpressionAtlasiQ86UY0. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALS2CR12Q96Q353EBI-2825190,EBI-750451
BLZF1Q9H2G93EBI-2825190,EBI-2548012
EFEMP1Q128053EBI-2825190,EBI-536772
GMPPBQ9Y5P63EBI-2825190,EBI-750945
KRT38O760153EBI-2825190,EBI-1047263
KRT40Q6A1623EBI-2825190,EBI-10171697
KRTAP10-5P603703EBI-2825190,EBI-10172150
KRTAP10-7P604093EBI-2825190,EBI-10172290
KRTAP10-8P604103EBI-2825190,EBI-10171774
KRTAP10-9P604113EBI-2825190,EBI-10172052
KRTAP4-12Q9BQ663EBI-2825190,EBI-739863
KRTAP4-2Q9BYR53EBI-2825190,EBI-10172511
LHX4Q969G23EBI-2825190,EBI-2865388
NOTCH2NLQ7Z3S93EBI-2825190,EBI-945833
SPRY2O435973EBI-2825190,EBI-742487
TRIM23P364063EBI-2825190,EBI-740098
TRIM42A1L4B63EBI-2825190,EBI-10172216
TRIP6Q156543EBI-2825190,EBI-742327

Protein-protein interaction databases

IntActiQ86UY0. 20 interactions.
STRINGi9606.ENSP00000369081.

Structurei

3D structure databases

ProteinModelPortaliQ86UY0.
SMRiQ86UY0. Positions 17-98, 118-224, 251-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotation
Contains 2 thioredoxin domains.UniRule annotation

Keywords - Domaini

Redox-active centerSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00730000110455.
HOVERGENiHBG058611.
PhylomeDBiQ86UY0.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86UY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSVDSNRG NRNEKRCGHC QRLQPTWNDL GDKYNSMEDA KVYVAKVDCT
60 70 80 90 100
AHSDVCSAQG VRGYPTLKLF KPGQEAVKYQ GPRDFQTLEN WMLQTLNEEP
110 120 130 140 150
VTPEPEVEPP SAPELKQGLY ELSASNFELH VAQGDHFIKF FAPWCGHCKA
160 170 180 190 200
LAPTWEQLAL GLEHSETVKI GKVDCTQHYE LCSGNQVRGY PTLLWFRDGK
210 220 230 240 250
KVDQYKGKRD LESLREYVES QLQRTETGAT ETVTPSEAPV LAAEPEADKG
260 270 280 290 300
TVLALTENNF DDTIAEGITF IKFYAPWCGH CKTLAPTWEE LSKKEFPGLA
310 320 330 340 350
GVKIAEVDCT AERNICSKYS VRGYPTLLLF RGGKKVSEHS GGRDLDSLHR
360
FVLSQAKDEL
Length:360
Mass (Da):40,369
Last modified:June 1, 2003 - v1
Checksum:i32A402B0D2E8D18A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023694 Genomic DNA. No translation available.
AL096800 Genomic DNA. No translation available.
AL133541 Genomic DNA. No translation available.
BC052310 mRNA. Translation: AAH52310.1.
UniGeneiHs.150837.

Genome annotation databases

EnsembliENST00000539054; ENSP00000442453; ENSG00000259040.
UCSCiuc003mxw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023694 Genomic DNA. No translation available.
AL096800 Genomic DNA. No translation available.
AL133541 Genomic DNA. No translation available.
BC052310 mRNA. Translation: AAH52310.1.
UniGeneiHs.150837.

3D structure databases

ProteinModelPortaliQ86UY0.
SMRiQ86UY0. Positions 17-98, 118-224, 251-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86UY0. 20 interactions.
STRINGi9606.ENSP00000369081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000539054; ENSP00000442453; ENSG00000259040.
UCSCiuc003mxw.3. human.

Organism-specific databases

HGNCiHGNC:42001. BLOC1S5-TXNDC5.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000110455.
HOVERGENiHBG058611.
PhylomeDBiQ86UY0.

Miscellaneous databases

ChiTaRSiTXNDC5. human.

Gene expression databases

ExpressionAtlasiQ86UY0. baseline.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: OvaryImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ86UY0_HUMAN
AccessioniPrimary (citable) accession number: Q86UY0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 24, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.