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Q86UX6

- ST32C_HUMAN

UniProt

Q86UX6 - ST32C_HUMAN

Protein

Serine/threonine-protein kinase 32C

Gene

STK32C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.By similarity

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei122 – 1221ATPBy similarityPROSITE-ProRule annotation
    Active sitei216 – 2161Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi99 – 1079ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ86UX6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase 32C (EC:2.7.11.1)
    Alternative name(s):
    PKE
    Yet another novel kinase 3
    Gene namesi
    Name:STK32CImported
    Synonyms:YANK3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:21332. STK32C.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134888050.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Serine/threonine-protein kinase 32CPRO_0000232415Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei15 – 151Phosphoserine1 Publication
    Modified residuei18 – 181Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86UX6.
    PaxDbiQ86UX6.
    PRIDEiQ86UX6.

    PTM databases

    PhosphoSiteiQ86UX6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86UX6.
    BgeeiQ86UX6.
    CleanExiHS_STK32C.
    GenevestigatoriQ86UX6.

    Organism-specific databases

    HPAiHPA017894.

    Interactioni

    Protein-protein interaction databases

    BioGridi129429. 4 interactions.
    IntActiQ86UX6. 2 interactions.
    STRINGi9606.ENSP00000298630.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UX6.
    SMRiQ86UX6. Positions 22-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 353261Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000021314.
    HOVERGENiHBG106458.
    InParanoidiQ86UX6.
    KOiK08793.
    PhylomeDBiQ86UX6.
    TreeFamiTF313395.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86UX6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRSGAERRGS SAAASPGSPP PGRARPAGSD APSALPPPAA GQPRARDSGD    50
    VRSQPRPLFQ WSKWKKRMGS SMSAATARRP VFDDKEDVNF DHFQILRAIG 100
    KGSFGKVCIV QKRDTEKMYA MKYMNKQQCI ERDEVRNVFR ELEILQEIEH 150
    VFLVNLWYSF QDEEDMFMVV DLLLGGDLRY HLQQNVQFSE DTVRLYICEM 200
    ALALDYLRGQ HIIHRDVKPD NILLDERGHA HLTDFNIATI IKDGERATAL 250
    AGTKPYMAPE IFHSFVNGGT GYSFEVDWWS VGVMAYELLR GWRPYDIHSS 300
    NAVESLVQLF STVSVQYVPT WSKEMVALLR KLLTVNPEHR LSSLQDVQAA 350
    PALAGVLWDH LSEKRVEPGF VPNKGRLHCD PTFELEEMIL ESRPLHKKKK 400
    RLAKNKSRDN SRDSSQSEND YLQDCLDAIQ QDFVIFNREK LKRSQDLPRE 450
    PLPAPESRDA AEPVEDEAER SALPMCGPIC PSAGSG 486
    Length:486
    Mass (Da):54,994
    Last modified:June 1, 2003 - v1
    Checksum:i38FEFBB3863B21F3
    GO
    Isoform 21 Publication (identifier: Q86UX6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-117: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:369
    Mass (Da):42,425
    Checksum:i83C54C4AF7D792E5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti334 – 3341T → A.1 Publication
    Corresponds to variant rs17854384 [ dbSNP | Ensembl ].
    VAR_025900
    Natural varianti376 – 3761R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035637
    Natural varianti454 – 4541A → T.1 Publication
    Corresponds to variant rs56109103 [ dbSNP | Ensembl ].
    VAR_041170
    Natural varianti467 – 4671E → K.1 Publication
    Corresponds to variant rs55812591 [ dbSNP | Ensembl ].
    VAR_041171

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 117117Missing in isoform 2. 1 PublicationVSP_051998Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY098866 mRNA. Translation: AAM21719.1.
    AL512622, AL590105 Genomic DNA. Translation: CAI12181.1.
    AL512622 Genomic DNA. Translation: CAI12187.1.
    AL590105, AL512622 Genomic DNA. Translation: CAI13011.1.
    BC045760 mRNA. Translation: AAH45760.1.
    CCDSiCCDS7666.1. [Q86UX6-1]
    RefSeqiNP_775846.2. NM_173575.2. [Q86UX6-1]
    UniGeneiHs.469002.

    Genome annotation databases

    EnsembliENST00000298630; ENSP00000298630; ENSG00000165752. [Q86UX6-1]
    ENST00000368622; ENSP00000357611; ENSG00000165752. [Q86UX6-2]
    GeneIDi282974.
    KEGGihsa:282974.
    UCSCiuc001lld.1. human. [Q86UX6-1]

    Polymorphism databases

    DMDMi74762451.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY098866 mRNA. Translation: AAM21719.1 .
    AL512622 , AL590105 Genomic DNA. Translation: CAI12181.1 .
    AL512622 Genomic DNA. Translation: CAI12187.1 .
    AL590105 , AL512622 Genomic DNA. Translation: CAI13011.1 .
    BC045760 mRNA. Translation: AAH45760.1 .
    CCDSi CCDS7666.1. [Q86UX6-1 ]
    RefSeqi NP_775846.2. NM_173575.2. [Q86UX6-1 ]
    UniGenei Hs.469002.

    3D structure databases

    ProteinModelPortali Q86UX6.
    SMRi Q86UX6. Positions 22-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129429. 4 interactions.
    IntActi Q86UX6. 2 interactions.
    STRINGi 9606.ENSP00000298630.

    Chemistry

    BindingDBi Q86UX6.
    ChEMBLi CHEMBL5405.
    GuidetoPHARMACOLOGYi 1539.

    PTM databases

    PhosphoSitei Q86UX6.

    Polymorphism databases

    DMDMi 74762451.

    Proteomic databases

    MaxQBi Q86UX6.
    PaxDbi Q86UX6.
    PRIDEi Q86UX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298630 ; ENSP00000298630 ; ENSG00000165752 . [Q86UX6-1 ]
    ENST00000368622 ; ENSP00000357611 ; ENSG00000165752 . [Q86UX6-2 ]
    GeneIDi 282974.
    KEGGi hsa:282974.
    UCSCi uc001lld.1. human. [Q86UX6-1 ]

    Organism-specific databases

    CTDi 282974.
    GeneCardsi GC10M134020.
    HGNCi HGNC:21332. STK32C.
    HPAi HPA017894.
    neXtProti NX_Q86UX6.
    PharmGKBi PA134888050.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000021314.
    HOVERGENi HBG106458.
    InParanoidi Q86UX6.
    KOi K08793.
    PhylomeDBi Q86UX6.
    TreeFami TF313395.

    Enzyme and pathway databases

    SignaLinki Q86UX6.

    Miscellaneous databases

    GenomeRNAii 282974.
    NextBioi 93549.
    PROi Q86UX6.

    Gene expression databases

    ArrayExpressi Q86UX6.
    Bgeei Q86UX6.
    CleanExi HS_STK32C.
    Genevestigatori Q86UX6.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PKE, a new human AGC group kinase, phosphorylates SET, a PP2A inhibitor."
      Ma A.-H., Nelson D.A., Xia L., Ravi L., Chen H.-C., Robinson D.R., Kung H.-J.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-334.
      Tissue: TestisImported.
    4. Cited for: NOMENCLATURE.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-376.
    7. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-454 AND LYS-467.

    Entry informationi

    Entry nameiST32C_HUMAN
    AccessioniPrimary (citable) accession number: Q86UX6
    Secondary accession number(s): Q5T0Q5, Q86UE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3