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Q86UX6 (ST32C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase 32C

EC=2.7.11.1
Alternative name(s):
PKE
Yet another novel kinase 3
Gene names
Name:STK32C
Synonyms:YANK3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB Q60592

Cofactor

Magnesium By similarity. UniProtKB Q60592

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.5 (identifier: Q86UX6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.3 (identifier: Q86UX6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Serine/threonine-protein kinase 32C
PRO_0000232415

Regions

Domain93 – 353261Protein kinase
Nucleotide binding99 – 1079ATP By similarity UniProtKB Q60592

Sites

Active site2161Proton acceptor By similarity UniProtKB Q60592
Binding site1221ATP By similarity UniProtKB Q60592

Amino acid modifications

Modified residue151Phosphoserine Ref.5
Modified residue181Phosphoserine Ref.5

Natural variations

Alternative sequence1 – 117117Missing in isoform 2. Ref.5
VSP_051998
Natural variant3341T → A. Ref.3 Ref.4
Corresponds to variant rs17854384 [ dbSNP | Ensembl ].
VAR_025900
Natural variant3761R → H in a colorectal cancer sample; somatic mutation. Ref.6
VAR_035637
Natural variant4541A → T. Ref.7
Corresponds to variant rs56109103 [ dbSNP | Ensembl ].
VAR_041170
Natural variant4671E → K. Ref.7
Corresponds to variant rs55812591 [ dbSNP | Ensembl ].
VAR_041171

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 38FEFBB3863B21F3

FASTA48654,994
        10         20         30         40         50         60 
MRSGAERRGS SAAASPGSPP PGRARPAGSD APSALPPPAA GQPRARDSGD VRSQPRPLFQ 

        70         80         90        100        110        120 
WSKWKKRMGS SMSAATARRP VFDDKEDVNF DHFQILRAIG KGSFGKVCIV QKRDTEKMYA 

       130        140        150        160        170        180 
MKYMNKQQCI ERDEVRNVFR ELEILQEIEH VFLVNLWYSF QDEEDMFMVV DLLLGGDLRY 

       190        200        210        220        230        240 
HLQQNVQFSE DTVRLYICEM ALALDYLRGQ HIIHRDVKPD NILLDERGHA HLTDFNIATI 

       250        260        270        280        290        300 
IKDGERATAL AGTKPYMAPE IFHSFVNGGT GYSFEVDWWS VGVMAYELLR GWRPYDIHSS 

       310        320        330        340        350        360 
NAVESLVQLF STVSVQYVPT WSKEMVALLR KLLTVNPEHR LSSLQDVQAA PALAGVLWDH 

       370        380        390        400        410        420 
LSEKRVEPGF VPNKGRLHCD PTFELEEMIL ESRPLHKKKK RLAKNKSRDN SRDSSQSEND 

       430        440        450        460        470        480 
YLQDCLDAIQ QDFVIFNREK LKRSQDLPRE PLPAPESRDA AEPVEDEAER SALPMCGPIC 


PSAGSG 

« Hide

Isoform 2 [UniParc].

Checksum: 83C54C4AF7D792E5
Show »

FASTA36942,425

References

« Hide 'large scale' references
[1]"PKE, a new human AGC group kinase, phosphorylates SET, a PP2A inhibitor."
Ma A.-H., Nelson D.A., Xia L., Ravi L., Chen H.-C., Robinson D.R., Kung H.-J.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-334.
Tissue: Testis.
[4]"The protein kinase complement of the human genome."
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.
Science 298:1912-1934(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-376.
[7]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-454 AND LYS-467.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY098866 mRNA. Translation: AAM21719.1.
AL512622, AL590105 Genomic DNA. Translation: CAI12181.1.
AL512622 Genomic DNA. Translation: CAI12187.1.
AL590105, AL512622 Genomic DNA. Translation: CAI13011.1.
BC045760 mRNA. Translation: AAH45760.1.
RefSeqNP_775846.2. NM_173575.2.
UniGeneHs.469002.

3D structure databases

ProteinModelPortalQ86UX6.
SMRQ86UX6. Positions 22-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129429. 4 interactions.
IntActQ86UX6. 2 interactions.
STRING9606.ENSP00000298630.

Chemistry

BindingDBQ86UX6.
ChEMBLCHEMBL5405.
GuidetoPHARMACOLOGY1539.

PTM databases

PhosphoSiteQ86UX6.

Polymorphism databases

DMDM74762451.

Proteomic databases

PaxDbQ86UX6.
PRIDEQ86UX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298630; ENSP00000298630; ENSG00000165752. [Q86UX6-1]
ENST00000368622; ENSP00000357611; ENSG00000165752. [Q86UX6-2]
GeneID282974.
KEGGhsa:282974.
UCSCuc001lld.1. human. [Q86UX6-1]

Organism-specific databases

CTD282974.
GeneCardsGC10M134020.
HGNCHGNC:21332. STK32C.
HPAHPA017894.
neXtProtNX_Q86UX6.
PharmGKBPA134888050.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000021314.
HOVERGENHBG106458.
InParanoidQ86UX6.
KOK08793.
PhylomeDBQ86UX6.
TreeFamTF313395.

Enzyme and pathway databases

SignaLinkQ86UX6.

Gene expression databases

ArrayExpressQ86UX6.
BgeeQ86UX6.
CleanExHS_STK32C.
GenevestigatorQ86UX6.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi282974.
NextBio93549.
PROQ86UX6.

Entry information

Entry nameST32C_HUMAN
AccessionPrimary (citable) accession number: Q86UX6
Secondary accession number(s): Q5T0Q5, Q86UE1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2003
Last modified: March 19, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM