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Q86UX6

- ST32C_HUMAN

UniProt

Q86UX6 - ST32C_HUMAN

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Protein

Serine/threonine-protein kinase 32C

Gene

STK32C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221ATPBy similarityPROSITE-ProRule annotation
Active sitei216 – 2161Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi99 – 1079ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ86UX6.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 32C (EC:2.7.11.1)
Alternative name(s):
PKE
Yet another novel kinase 3
Gene namesi
Name:STK32CImported
Synonyms:YANK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:21332. STK32C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134888050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Serine/threonine-protein kinase 32CPRO_0000232415Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine1 Publication
Modified residuei18 – 181Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86UX6.
PaxDbiQ86UX6.
PRIDEiQ86UX6.

PTM databases

PhosphoSiteiQ86UX6.

Expressioni

Gene expression databases

BgeeiQ86UX6.
CleanExiHS_STK32C.
ExpressionAtlasiQ86UX6. baseline and differential.
GenevestigatoriQ86UX6.

Organism-specific databases

HPAiHPA017894.

Interactioni

Protein-protein interaction databases

BioGridi129429. 9 interactions.
IntActiQ86UX6. 2 interactions.
STRINGi9606.ENSP00000298630.

Structurei

3D structure databases

ProteinModelPortaliQ86UX6.
SMRiQ86UX6. Positions 22-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 353261Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00670000097961.
HOGENOMiHOG000021314.
HOVERGENiHBG106458.
InParanoidiQ86UX6.
KOiK08793.
PhylomeDBiQ86UX6.
TreeFamiTF313395.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86UX6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSGAERRGS SAAASPGSPP PGRARPAGSD APSALPPPAA GQPRARDSGD
60 70 80 90 100
VRSQPRPLFQ WSKWKKRMGS SMSAATARRP VFDDKEDVNF DHFQILRAIG
110 120 130 140 150
KGSFGKVCIV QKRDTEKMYA MKYMNKQQCI ERDEVRNVFR ELEILQEIEH
160 170 180 190 200
VFLVNLWYSF QDEEDMFMVV DLLLGGDLRY HLQQNVQFSE DTVRLYICEM
210 220 230 240 250
ALALDYLRGQ HIIHRDVKPD NILLDERGHA HLTDFNIATI IKDGERATAL
260 270 280 290 300
AGTKPYMAPE IFHSFVNGGT GYSFEVDWWS VGVMAYELLR GWRPYDIHSS
310 320 330 340 350
NAVESLVQLF STVSVQYVPT WSKEMVALLR KLLTVNPEHR LSSLQDVQAA
360 370 380 390 400
PALAGVLWDH LSEKRVEPGF VPNKGRLHCD PTFELEEMIL ESRPLHKKKK
410 420 430 440 450
RLAKNKSRDN SRDSSQSEND YLQDCLDAIQ QDFVIFNREK LKRSQDLPRE
460 470 480
PLPAPESRDA AEPVEDEAER SALPMCGPIC PSAGSG
Length:486
Mass (Da):54,994
Last modified:June 1, 2003 - v1
Checksum:i38FEFBB3863B21F3
GO
Isoform 21 Publication (identifier: Q86UX6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:369
Mass (Da):42,425
Checksum:i83C54C4AF7D792E5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti334 – 3341T → A.1 Publication
Corresponds to variant rs17854384 [ dbSNP | Ensembl ].
VAR_025900
Natural varianti376 – 3761R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035637
Natural varianti454 – 4541A → T.1 Publication
Corresponds to variant rs56109103 [ dbSNP | Ensembl ].
VAR_041170
Natural varianti467 – 4671E → K.1 Publication
Corresponds to variant rs55812591 [ dbSNP | Ensembl ].
VAR_041171

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 117117Missing in isoform 2. 1 PublicationVSP_051998Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY098866 mRNA. Translation: AAM21719.1.
AL512622, AL590105 Genomic DNA. Translation: CAI12181.1.
AL512622 Genomic DNA. Translation: CAI12187.1.
AL590105, AL512622 Genomic DNA. Translation: CAI13011.1.
BC045760 mRNA. Translation: AAH45760.1.
CCDSiCCDS7666.1. [Q86UX6-1]
RefSeqiNP_775846.2. NM_173575.2. [Q86UX6-1]
UniGeneiHs.469002.

Genome annotation databases

EnsembliENST00000298630; ENSP00000298630; ENSG00000165752. [Q86UX6-1]
ENST00000368622; ENSP00000357611; ENSG00000165752. [Q86UX6-2]
GeneIDi282974.
KEGGihsa:282974.
UCSCiuc001lld.1. human. [Q86UX6-1]

Polymorphism databases

DMDMi74762451.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY098866 mRNA. Translation: AAM21719.1 .
AL512622 , AL590105 Genomic DNA. Translation: CAI12181.1 .
AL512622 Genomic DNA. Translation: CAI12187.1 .
AL590105 , AL512622 Genomic DNA. Translation: CAI13011.1 .
BC045760 mRNA. Translation: AAH45760.1 .
CCDSi CCDS7666.1. [Q86UX6-1 ]
RefSeqi NP_775846.2. NM_173575.2. [Q86UX6-1 ]
UniGenei Hs.469002.

3D structure databases

ProteinModelPortali Q86UX6.
SMRi Q86UX6. Positions 22-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129429. 9 interactions.
IntActi Q86UX6. 2 interactions.
STRINGi 9606.ENSP00000298630.

Chemistry

BindingDBi Q86UX6.
ChEMBLi CHEMBL5405.
GuidetoPHARMACOLOGYi 1539.

PTM databases

PhosphoSitei Q86UX6.

Polymorphism databases

DMDMi 74762451.

Proteomic databases

MaxQBi Q86UX6.
PaxDbi Q86UX6.
PRIDEi Q86UX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298630 ; ENSP00000298630 ; ENSG00000165752 . [Q86UX6-1 ]
ENST00000368622 ; ENSP00000357611 ; ENSG00000165752 . [Q86UX6-2 ]
GeneIDi 282974.
KEGGi hsa:282974.
UCSCi uc001lld.1. human. [Q86UX6-1 ]

Organism-specific databases

CTDi 282974.
GeneCardsi GC10M134020.
HGNCi HGNC:21332. STK32C.
HPAi HPA017894.
neXtProti NX_Q86UX6.
PharmGKBi PA134888050.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00670000097961.
HOGENOMi HOG000021314.
HOVERGENi HBG106458.
InParanoidi Q86UX6.
KOi K08793.
PhylomeDBi Q86UX6.
TreeFami TF313395.

Enzyme and pathway databases

SignaLinki Q86UX6.

Miscellaneous databases

GenomeRNAii 282974.
NextBioi 93549.
PROi Q86UX6.

Gene expression databases

Bgeei Q86UX6.
CleanExi HS_STK32C.
ExpressionAtlasi Q86UX6. baseline and differential.
Genevestigatori Q86UX6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PKE, a new human AGC group kinase, phosphorylates SET, a PP2A inhibitor."
    Ma A.-H., Nelson D.A., Xia L., Ravi L., Chen H.-C., Robinson D.R., Kung H.-J.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-334.
    Tissue: TestisImported.
  4. Cited for: NOMENCLATURE.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-376.
  7. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-454 AND LYS-467.

Entry informationi

Entry nameiST32C_HUMAN
AccessioniPrimary (citable) accession number: Q86UX6
Secondary accession number(s): Q5T0Q5, Q86UE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3