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Protein

Inter-alpha-trypsin inhibitor heavy chain H5

Gene

ITIH5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a tumor suppressor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H5
Short name:
ITI heavy chain H5
Short name:
ITI-HC5
Short name:
Inter-alpha-inhibitor heavy chain 5
Gene namesi
Name:ITIH5
Synonyms:KIAA1953
ORF Names:PP14776, UNQ311/PRO354
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21449. ITIH5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899668.

Polymorphism and mutation databases

BioMutaiITIH5.
DMDMi187609608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 942926Inter-alpha-trypsin inhibitor heavy chain H5PRO_0000331408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence analysis
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence analysis
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence analysis
Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence analysis
Glycosylationi795 – 7951N-linked (GlcNAc...)Sequence analysis
Glycosylationi862 – 8621N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ86UX2.
PaxDbiQ86UX2.
PeptideAtlasiQ86UX2.
PRIDEiQ86UX2.

PTM databases

iPTMnetiQ86UX2.
PhosphoSiteiQ86UX2.

Expressioni

Tissue specificityi

Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression is barely detectable levels in all other tissues tested.1 Publication

Inductioni

Down-regulated in breast tumors.1 Publication

Gene expression databases

BgeeiQ86UX2.

Organism-specific databases

HPAiHPA038305.

Interactioni

Protein-protein interaction databases

BioGridi123294. 10 interactions.
IntActiQ86UX2. 9 interactions.
STRINGi9606.ENSP00000256861.

Structurei

3D structure databases

ProteinModelPortaliQ86UX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 161127VITPROSITE-ProRule annotationAdd
BLAST
Domaini295 – 478184VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ITIH family.Curated
Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
HOVERGENiHBG108012.
InParanoidiQ86UX2.
OrthoDBiEOG7CRTP5.
PhylomeDBiQ86UX2.
TreeFamiTF328982.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF13768. VWA_3. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLLGLCLG LSLCVGSQEE AQSWGHSSEQ DGLRVPRQVR LLQRLKTKPL
60 70 80 90 100
MTEFSVKSTI ISRYAFTTVS CRMLNRASED QDIEFQMQIP AAAFITNFTM
110 120 130 140 150
LIGDKVYQGE ITEREKKSGD RVKEKRNKTT EENGEKGTEI FRASAVIPSK
160 170 180 190 200
DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ LSGRLSVDVN ILESAGIASL
210 220 230 240 250
EVLPLHNSRQ RGSGRGEDDS GPPPSTVINQ NETFANIIFK PTVVQQARIA
260 270 280 290 300
QNGILGDFII RYDVNREQSI GDIQVLNGYF VHYFAPKDLP PLPKNVVFVL
310 320 330 340 350
DSSASMVGTK LRQTKDALFT ILHDLRPQDR FSIIGFSNRI KVWKDHLISV
360 370 380 390 400
TPDSIRDGKV YIHHMSPTGG TDINGALQRA IRLLNKYVAH SGIGDRSVSL
410 420 430 440 450
IVFLTDGKPT VGETHTLKIL NNTREAARGQ VCIFTIGIGN DVDFRLLEKL
460 470 480 490 500
SLENCGLTRR VHEEEDAGSQ LIGFYDEIRT PLLSDIRIDY PPSSVVQATK
510 520 530 540 550
TLFPNYFNGS EIIIAGKLVD RKLDHLHVEV TASNSKKFII LKTDVPVRPQ
560 570 580 590 600
KAGKDVTGSP RPGGDGEGDT NHIERLWSYL TTKELLSSWL QSDDEPEKER
610 620 630 640 650
LRQRAQALAV SYRFLTPFTS MKLRGPVPRM DGLEEAHGMS AAMGPEPVVQ
660 670 680 690 700
SVRGAGTQPG PLLKKPYQPR IKISKTSVDG DPHFVVDFPL SRLTVCFNID
710 720 730 740 750
GQPGDILRLV SDHRDSGVTV NGELIGAPAP PNGHKKQRTY LRTITILINK
760 770 780 790 800
PERSYLEITP SRVILDGGDR LVLPCNQSVV VGSWGLEVSV SANANVTVTI
810 820 830 840 850
QGSIAFVILI HLYKKPAPFQ RHHLGFYIAN SEGLSSNCHG LLGQFLNQDA
860 870 880 890 900
RLTEDPAGPS QNLTHPLLLQ VGEGPEAVLT VKGHQVPVVW KQRKIYNGEE
910 920 930 940
QIDCWFARNN AAKLIDGEYK DYLAFHPFDT GMTLGQGMSR EL
Length:942
Mass (Da):104,576
Last modified:April 29, 2008 - v2
Checksum:i1666BE1C9B90ED61
GO
Isoform 2 (identifier: Q86UX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-694: YQPRIKISKTSVDGDPHFVVDFPLSRLT → NSVKKKQNKTKKRHGRDGVFPLHHLGIR
     695-942: Missing.

Show »
Length:694
Mass (Da):77,401
Checksum:i42882C40AA8E4634
GO
Isoform 3 (identifier: Q86UX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-218: RGED → MRNY

Show »
Length:728
Mass (Da):80,664
Checksum:i11911A82F89BCECA
GO
Isoform 4 (identifier: Q86UX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-449: Missing.
     450-473: LSLENCGLTRRVHEEEDAGSQLIG → MRTYDTPGTSMCIIPDDPHRNPRR
     678-693: VDGDPHFVVDFPLSRL → GKAKDAVVCGLRVRDV
     694-942: Missing.

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):27,191
Checksum:i5E73E0B94241F8AB
GO

Sequence cautioni

The sequence CAI12953.1 differs from that shown. Reason: Frameshift at position 933. Curated
The sequence CAI12955.1 differs from that shown. Reason: Frameshift at position 933. Curated
The sequence CAI16360.1 differs from that shown. Reason: Frameshift at position 933. Curated
The sequence CAI16363.1 differs from that shown. Reason: Frameshift at position 933. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881D → G in BAB55070 (PubMed:14702039).Curated
Sequence conflicti337 – 3371S → P in BAB55070 (PubMed:14702039).Curated
Sequence conflicti343 – 3431W → R in CAH10363 (PubMed:17974005).Curated
Sequence conflicti936 – 9361Q → R in AAO49812 (PubMed:14744536).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391E → K.
Corresponds to variant rs12761771 [ dbSNP | Ensembl ].
VAR_042847
Natural varianti207 – 2071N → H.
Corresponds to variant rs36056263 [ dbSNP | Ensembl ].
VAR_042848
Natural varianti421 – 4211N → H.
Corresponds to variant rs36056263 [ dbSNP | Ensembl ].
VAR_055973
Natural varianti496 – 4961V → M.
Corresponds to variant rs35892621 [ dbSNP | Ensembl ].
VAR_061276
Natural varianti570 – 5701T → P.4 Publications
Corresponds to variant rs2275069 [ dbSNP | Ensembl ].
VAR_042849
Natural varianti629 – 6291R → C.
Corresponds to variant rs34213756 [ dbSNP | Ensembl ].
VAR_042850
Natural varianti925 – 9251F → S.2 Publications
Corresponds to variant rs10795551 [ dbSNP | Ensembl ].
VAR_055974

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 449449Missing in isoform 4. 1 PublicationVSP_035727Add
BLAST
Alternative sequencei1 – 214214Missing in isoform 3. CuratedVSP_033188Add
BLAST
Alternative sequencei215 – 2184RGED → MRNY in isoform 3. CuratedVSP_033189
Alternative sequencei450 – 47324LSLEN…SQLIG → MRTYDTPGTSMCIIPDDPHR NPRR in isoform 4. 1 PublicationVSP_035728Add
BLAST
Alternative sequencei667 – 69428YQPRI…LSRLT → NSVKKKQNKTKKRHGRDGVF PLHHLGIR in isoform 2. 1 PublicationVSP_033190Add
BLAST
Alternative sequencei678 – 69316VDGDP…PLSRL → GKAKDAVVCGLRVRDV in isoform 4. 1 PublicationVSP_035729Add
BLAST
Alternative sequencei694 – 942249Missing in isoform 4. 1 PublicationVSP_035730Add
BLAST
Alternative sequencei695 – 942248Missing in isoform 2. 1 PublicationVSP_033191Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238437 mRNA. Translation: AAO49812.1.
AY358426 mRNA. Translation: AAQ88792.1.
AK027375 mRNA. Translation: BAB55070.1.
AF318347 mRNA. Translation: AAL55854.1.
AL158044, AL355374 Genomic DNA. Translation: CAI12953.1. Frameshift.
AL158044, AL355374 Genomic DNA. Translation: CAI12955.1. Frameshift.
AL355374, AL158044 Genomic DNA. Translation: CAI16360.1. Frameshift.
AL355374 Genomic DNA. Translation: CAI16362.1.
AL355374, AL158044 Genomic DNA. Translation: CAI16363.1. Frameshift.
CH471072 Genomic DNA. Translation: EAW86379.1.
AB075833 mRNA. Translation: BAB85539.1.
CR627109 mRNA. Translation: CAH10363.1.
RefSeqiNP_001001851.1. NM_001001851.2.
NP_085046.5. NM_030569.6.
UniGeneiHs.498586.
Hs.732936.

Genome annotation databases

EnsembliENST00000256861; ENSP00000256861; ENSG00000123243.
ENST00000298441; ENSP00000298441; ENSG00000123243.
GeneIDi80760.
KEGGihsa:80760.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238437 mRNA. Translation: AAO49812.1.
AY358426 mRNA. Translation: AAQ88792.1.
AK027375 mRNA. Translation: BAB55070.1.
AF318347 mRNA. Translation: AAL55854.1.
AL158044, AL355374 Genomic DNA. Translation: CAI12953.1. Frameshift.
AL158044, AL355374 Genomic DNA. Translation: CAI12955.1. Frameshift.
AL355374, AL158044 Genomic DNA. Translation: CAI16360.1. Frameshift.
AL355374 Genomic DNA. Translation: CAI16362.1.
AL355374, AL158044 Genomic DNA. Translation: CAI16363.1. Frameshift.
CH471072 Genomic DNA. Translation: EAW86379.1.
AB075833 mRNA. Translation: BAB85539.1.
CR627109 mRNA. Translation: CAH10363.1.
RefSeqiNP_001001851.1. NM_001001851.2.
NP_085046.5. NM_030569.6.
UniGeneiHs.498586.
Hs.732936.

3D structure databases

ProteinModelPortaliQ86UX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123294. 10 interactions.
IntActiQ86UX2. 9 interactions.
STRINGi9606.ENSP00000256861.

PTM databases

iPTMnetiQ86UX2.
PhosphoSiteiQ86UX2.

Polymorphism and mutation databases

BioMutaiITIH5.
DMDMi187609608.

Proteomic databases

EPDiQ86UX2.
PaxDbiQ86UX2.
PeptideAtlasiQ86UX2.
PRIDEiQ86UX2.

Protocols and materials databases

DNASUi80760.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256861; ENSP00000256861; ENSG00000123243.
ENST00000298441; ENSP00000298441; ENSG00000123243.
GeneIDi80760.
KEGGihsa:80760.

Organism-specific databases

CTDi80760.
GeneCardsiITIH5.
HGNCiHGNC:21449. ITIH5.
HPAiHPA038305.
MIMi609783. gene.
neXtProtiNX_Q86UX2.
PharmGKBiPA134899668.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
HOVERGENiHBG108012.
InParanoidiQ86UX2.
OrthoDBiEOG7CRTP5.
PhylomeDBiQ86UX2.
TreeFamiTF328982.

Miscellaneous databases

ChiTaRSiITIH5. human.
GenomeRNAii80760.
PROiQ86UX2.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UX2.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF13768. VWA_3. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer."
    Himmelfarb M., Klopocki E., Grube S., Staub E., Klaman I., Hinzmann B., Kristiansen G., Rosenthal A., Duerst M., Dahl E.
    Cancer Lett. 204:69-77(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, VARIANT PRO-570.
    Tissue: Mammary gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-570 AND SER-925.
    Tissue: Mammary gland.
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT PRO-570.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-942 (ISOFORM 1), VARIANT SER-925.
    Tissue: Brain.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-677 (ISOFORM 1), VARIANT PRO-570.
    Tissue: Amygdala.

Entry informationi

Entry nameiITIH5_HUMAN
AccessioniPrimary (citable) accession number: Q86UX2
Secondary accession number(s): Q5T664
, Q5T665, Q5T666, Q6AI60, Q6UXB7, Q8TF48, Q8WYV2, Q96K70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 6, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Conflict in position 933 in the human genome assembly due to a frameshift.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.