Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inter-alpha-trypsin inhibitor heavy chain H5

Gene

ITIH5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a tumor suppressor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H5
Short name:
ITI heavy chain H5
Short name:
ITI-HC5
Short name:
Inter-alpha-inhibitor heavy chain 5
Gene namesi
Name:ITIH5
Synonyms:KIAA1953
ORF Names:PP14776, UNQ311/PRO354
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21449. ITIH5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi80760.
PharmGKBiPA134899668.

Polymorphism and mutation databases

BioMutaiITIH5.
DMDMi187609608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000033140817 – 942Inter-alpha-trypsin inhibitor heavy chain H5Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Glycosylationi421N-linked (GlcNAc...)Sequence analysis1
Glycosylationi508N-linked (GlcNAc...)Sequence analysis1
Glycosylationi776N-linked (GlcNAc...)Sequence analysis1
Glycosylationi795N-linked (GlcNAc...)Sequence analysis1
Glycosylationi862N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86UX2.
PeptideAtlasiQ86UX2.
PRIDEiQ86UX2.

PTM databases

iPTMnetiQ86UX2.
PhosphoSitePlusiQ86UX2.

Expressioni

Tissue specificityi

Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression is barely detectable levels in all other tissues tested.1 Publication

Inductioni

Down-regulated in breast tumors.1 Publication

Gene expression databases

BgeeiENSG00000123243.

Organism-specific databases

HPAiHPA038305.

Interactioni

Protein-protein interaction databases

BioGridi123294. 10 interactors.
IntActiQ86UX2. 9 interactors.
STRINGi9606.ENSP00000256861.

Structurei

3D structure databases

ProteinModelPortaliQ86UX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 161VITPROSITE-ProRule annotationAdd BLAST127
Domaini295 – 478VWFAPROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Belongs to the ITIH family.Curated
Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
HOVERGENiHBG108012.
InParanoidiQ86UX2.
PhylomeDBiQ86UX2.
TreeFamiTF328982.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF13768. VWA_3. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLLGLCLG LSLCVGSQEE AQSWGHSSEQ DGLRVPRQVR LLQRLKTKPL
60 70 80 90 100
MTEFSVKSTI ISRYAFTTVS CRMLNRASED QDIEFQMQIP AAAFITNFTM
110 120 130 140 150
LIGDKVYQGE ITEREKKSGD RVKEKRNKTT EENGEKGTEI FRASAVIPSK
160 170 180 190 200
DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ LSGRLSVDVN ILESAGIASL
210 220 230 240 250
EVLPLHNSRQ RGSGRGEDDS GPPPSTVINQ NETFANIIFK PTVVQQARIA
260 270 280 290 300
QNGILGDFII RYDVNREQSI GDIQVLNGYF VHYFAPKDLP PLPKNVVFVL
310 320 330 340 350
DSSASMVGTK LRQTKDALFT ILHDLRPQDR FSIIGFSNRI KVWKDHLISV
360 370 380 390 400
TPDSIRDGKV YIHHMSPTGG TDINGALQRA IRLLNKYVAH SGIGDRSVSL
410 420 430 440 450
IVFLTDGKPT VGETHTLKIL NNTREAARGQ VCIFTIGIGN DVDFRLLEKL
460 470 480 490 500
SLENCGLTRR VHEEEDAGSQ LIGFYDEIRT PLLSDIRIDY PPSSVVQATK
510 520 530 540 550
TLFPNYFNGS EIIIAGKLVD RKLDHLHVEV TASNSKKFII LKTDVPVRPQ
560 570 580 590 600
KAGKDVTGSP RPGGDGEGDT NHIERLWSYL TTKELLSSWL QSDDEPEKER
610 620 630 640 650
LRQRAQALAV SYRFLTPFTS MKLRGPVPRM DGLEEAHGMS AAMGPEPVVQ
660 670 680 690 700
SVRGAGTQPG PLLKKPYQPR IKISKTSVDG DPHFVVDFPL SRLTVCFNID
710 720 730 740 750
GQPGDILRLV SDHRDSGVTV NGELIGAPAP PNGHKKQRTY LRTITILINK
760 770 780 790 800
PERSYLEITP SRVILDGGDR LVLPCNQSVV VGSWGLEVSV SANANVTVTI
810 820 830 840 850
QGSIAFVILI HLYKKPAPFQ RHHLGFYIAN SEGLSSNCHG LLGQFLNQDA
860 870 880 890 900
RLTEDPAGPS QNLTHPLLLQ VGEGPEAVLT VKGHQVPVVW KQRKIYNGEE
910 920 930 940
QIDCWFARNN AAKLIDGEYK DYLAFHPFDT GMTLGQGMSR EL
Length:942
Mass (Da):104,576
Last modified:April 29, 2008 - v2
Checksum:i1666BE1C9B90ED61
GO
Isoform 2 (identifier: Q86UX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-694: YQPRIKISKTSVDGDPHFVVDFPLSRLT → NSVKKKQNKTKKRHGRDGVFPLHHLGIR
     695-942: Missing.

Show »
Length:694
Mass (Da):77,401
Checksum:i42882C40AA8E4634
GO
Isoform 3 (identifier: Q86UX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-218: RGED → MRNY

Show »
Length:728
Mass (Da):80,664
Checksum:i11911A82F89BCECA
GO
Isoform 4 (identifier: Q86UX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-449: Missing.
     450-473: LSLENCGLTRRVHEEEDAGSQLIG → MRTYDTPGTSMCIIPDDPHRNPRR
     678-693: VDGDPHFVVDFPLSRL → GKAKDAVVCGLRVRDV
     694-942: Missing.

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):27,191
Checksum:i5E73E0B94241F8AB
GO

Sequence cautioni

The sequence CAI12953 differs from that shown. Reason: Frameshift at position 933.Curated
The sequence CAI12955 differs from that shown. Reason: Frameshift at position 933.Curated
The sequence CAI16360 differs from that shown. Reason: Frameshift at position 933.Curated
The sequence CAI16363 differs from that shown. Reason: Frameshift at position 933.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188D → G in BAB55070 (PubMed:14702039).Curated1
Sequence conflicti337S → P in BAB55070 (PubMed:14702039).Curated1
Sequence conflicti343W → R in CAH10363 (PubMed:17974005).Curated1
Sequence conflicti936Q → R in AAO49812 (PubMed:14744536).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042847139E → K.Corresponds to variant rs12761771dbSNPEnsembl.1
Natural variantiVAR_042848207N → H.Corresponds to variant rs36056263dbSNPEnsembl.1
Natural variantiVAR_055973421N → H.Corresponds to variant rs36056263dbSNPEnsembl.1
Natural variantiVAR_061276496V → M.Corresponds to variant rs35892621dbSNPEnsembl.1
Natural variantiVAR_042849570T → P.4 PublicationsCorresponds to variant rs2275069dbSNPEnsembl.1
Natural variantiVAR_042850629R → C.Corresponds to variant rs34213756dbSNPEnsembl.1
Natural variantiVAR_055974925F → S.2 PublicationsCorresponds to variant rs10795551dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0357271 – 449Missing in isoform 4. 1 PublicationAdd BLAST449
Alternative sequenceiVSP_0331881 – 214Missing in isoform 3. CuratedAdd BLAST214
Alternative sequenceiVSP_033189215 – 218RGED → MRNY in isoform 3. Curated4
Alternative sequenceiVSP_035728450 – 473LSLEN…SQLIG → MRTYDTPGTSMCIIPDDPHR NPRR in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_033190667 – 694YQPRI…LSRLT → NSVKKKQNKTKKRHGRDGVF PLHHLGIR in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_035729678 – 693VDGDP…PLSRL → GKAKDAVVCGLRVRDV in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_035730694 – 942Missing in isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_033191695 – 942Missing in isoform 2. 1 PublicationAdd BLAST248

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238437 mRNA. Translation: AAO49812.1.
AY358426 mRNA. Translation: AAQ88792.1.
AK027375 mRNA. Translation: BAB55070.1.
AF318347 mRNA. Translation: AAL55854.1.
AL158044, AL355374 Genomic DNA. Translation: CAI12953.1. Frameshift.
AL158044, AL355374 Genomic DNA. Translation: CAI12955.1. Frameshift.
AL355374, AL158044 Genomic DNA. Translation: CAI16360.1. Frameshift.
AL355374 Genomic DNA. Translation: CAI16362.1.
AL355374, AL158044 Genomic DNA. Translation: CAI16363.1. Frameshift.
CH471072 Genomic DNA. Translation: EAW86379.1.
AB075833 mRNA. Translation: BAB85539.1.
CR627109 mRNA. Translation: CAH10363.1.
CCDSiCCDS31140.2. [Q86UX2-3]
RefSeqiNP_001001851.1. NM_001001851.2.
NP_085046.5. NM_030569.6.
UniGeneiHs.498586.
Hs.732936.

Genome annotation databases

EnsembliENST00000256861; ENSP00000256861; ENSG00000123243.
ENST00000298441; ENSP00000298441; ENSG00000123243.
GeneIDi80760.
KEGGihsa:80760.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238437 mRNA. Translation: AAO49812.1.
AY358426 mRNA. Translation: AAQ88792.1.
AK027375 mRNA. Translation: BAB55070.1.
AF318347 mRNA. Translation: AAL55854.1.
AL158044, AL355374 Genomic DNA. Translation: CAI12953.1. Frameshift.
AL158044, AL355374 Genomic DNA. Translation: CAI12955.1. Frameshift.
AL355374, AL158044 Genomic DNA. Translation: CAI16360.1. Frameshift.
AL355374 Genomic DNA. Translation: CAI16362.1.
AL355374, AL158044 Genomic DNA. Translation: CAI16363.1. Frameshift.
CH471072 Genomic DNA. Translation: EAW86379.1.
AB075833 mRNA. Translation: BAB85539.1.
CR627109 mRNA. Translation: CAH10363.1.
CCDSiCCDS31140.2. [Q86UX2-3]
RefSeqiNP_001001851.1. NM_001001851.2.
NP_085046.5. NM_030569.6.
UniGeneiHs.498586.
Hs.732936.

3D structure databases

ProteinModelPortaliQ86UX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123294. 10 interactors.
IntActiQ86UX2. 9 interactors.
STRINGi9606.ENSP00000256861.

PTM databases

iPTMnetiQ86UX2.
PhosphoSitePlusiQ86UX2.

Polymorphism and mutation databases

BioMutaiITIH5.
DMDMi187609608.

Proteomic databases

PaxDbiQ86UX2.
PeptideAtlasiQ86UX2.
PRIDEiQ86UX2.

Protocols and materials databases

DNASUi80760.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256861; ENSP00000256861; ENSG00000123243.
ENST00000298441; ENSP00000298441; ENSG00000123243.
GeneIDi80760.
KEGGihsa:80760.

Organism-specific databases

CTDi80760.
DisGeNETi80760.
GeneCardsiITIH5.
HGNCiHGNC:21449. ITIH5.
HPAiHPA038305.
MIMi609783. gene.
neXtProtiNX_Q86UX2.
PharmGKBiPA134899668.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
HOVERGENiHBG108012.
InParanoidiQ86UX2.
PhylomeDBiQ86UX2.
TreeFamiTF328982.

Miscellaneous databases

ChiTaRSiITIH5. human.
GenomeRNAii80760.
PROiQ86UX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123243.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF13768. VWA_3. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITIH5_HUMAN
AccessioniPrimary (citable) accession number: Q86UX2
Secondary accession number(s): Q5T664
, Q5T665, Q5T666, Q6AI60, Q6UXB7, Q8TF48, Q8WYV2, Q96K70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Conflict in position 933 in the human genome assembly due to a frameshift.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.