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Q86UW9

- DTX2_HUMAN

UniProt

Q86UW9 - DTX2_HUMAN

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Protein

Probable E3 ubiquitin-protein ligase DTX2

Gene

DTX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri412 – 47362RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. Notch signaling pathway Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Notch signaling pathway, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase DTX2 (EC:6.3.2.-)
Alternative name(s):
Protein deltex-2
Short name:
Deltex2
Short name:
hDTX2
RING finger protein 58
Gene namesi
Name:DTX2
Synonyms:KIAA1528, RNF58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:15973. DTX2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Predominantly cytoplasmic. Partially nuclear.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nuclear membrane Source: HPA
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Probable E3 ubiquitin-protein ligase DTX2PRO_0000219083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-acetyllysine1 Publication
Modified residuei360 – 3601Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ86UW9.
PaxDbiQ86UW9.
PRIDEiQ86UW9.

PTM databases

PhosphoSiteiQ86UW9.

Expressioni

Gene expression databases

BgeeiQ86UW9.
CleanExiHS_DTX2.
ExpressionAtlasiQ86UW9. baseline and differential.
GenevestigatoriQ86UW9.

Organism-specific databases

HPAiHPA042931.

Interactioni

Subunit structurei

Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
UBE2D4Q9Y2X83EBI-740376,EBI-745527

Protein-protein interaction databases

BioGridi125266. 16 interactions.
IntActiQ86UW9. 18 interactions.
MINTiMINT-1436106.
STRINGi9606.ENSP00000322885.

Structurei

3D structure databases

ProteinModelPortaliQ86UW9.
SMRiQ86UW9. Positions 18-182, 392-614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 9790WWE 1PROSITE-ProRule annotationAdd
BLAST
Domaini98 – 17477WWE 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.By similarity

Sequence similaritiesi

Belongs to the Deltex family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 2 WWE domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri412 – 47362RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0323.
GeneTreeiENSGT00440000035370.
HOGENOMiHOG000007352.
HOVERGENiHBG007213.
InParanoidiQ86UW9.
KOiK06058.
OMAiQPQGKME.
OrthoDBiEOG7J17ZB.
PhylomeDBiQ86UW9.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02825. WWE. 2 hits.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view]
PROSITEiPS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86UW9-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMAPSPSLV QVYTSPAAVA VWEWQDGLGT WHPYSATVCS FIEQQFVQQK
60 70 80 90 100
GQRFGLGSLA HSIPLGQADP SLAPYIIDLP SWTQFRQDTG TMRAVRRHLF
110 120 130 140 150
PQHSAPGRGV VWEWLSDDGS WTAYEASVCD YLEQQVARGN QLVDLAPLGY
160 170 180 190 200
NYTVNYTTHT QTNKTSSFCR SVRRQAGPPY PVTTIIAPPG HTGVACSCHQ
210 220 230 240 250
CLSGSRTGPV SGRYRHSMTN LPAYPVPQHP PHRTASVFGT HQAFAPYNKP
260 270 280 290 300
SLSGARSAPR LNTTNAWGAA PPSLGSQPLY RSSLSHLGPQ HLPPGSSTSG
310 320 330 340 350
AVSASLPSGP SSSPGSVPAT VPMQMPKPSR VQQALAGMTS VLMSAIGLPV
360 370 380 390 400
CLSRAPQPTS PPASRLASKS HGSVKRLRKM SVKGATPKPE PEPEQVIKNY
410 420 430 440 450
TEELKVPPDE DCIICMEKLS TASGYSDVTD SKAIGSLAVG HLTKCSHAFH
460 470 480 490 500
LLCLLAMYCN GNKDGSLQCP SCKTIYGEKT GTQPQGKMEV LRFQMSLPGH
510 520 530 540 550
EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE
560 570 580 590 600
LLKVAWKRRL IFTVGTSSTT GETDTVVWNE IHHKTEMDRN ITGHGYPDPN
610 620
YLQNVLAELA AQGVTEDCLE QQ
Length:622
Mass (Da):67,246
Last modified:June 21, 2005 - v3
Checksum:iABE1398204F2273A
GO
Isoform 2 (identifier: Q86UW9-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     337-383: Missing.

Show »
Length:575
Mass (Da):62,344
Checksum:i449202FB53C026B3
GO

Sequence cautioni

The sequence BAA96052.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941A → T.
Corresponds to variant rs2462312 [ dbSNP | Ensembl ].
VAR_016920
Natural varianti384 – 3841G → E.3 Publications
Corresponds to variant rs1638152 [ dbSNP | Ensembl ].
VAR_016921
Natural varianti421 – 4211T → A.2 Publications
Corresponds to variant rs6979487 [ dbSNP | Ensembl ].
VAR_016922

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei337 – 38347Missing in isoform 2. CuratedVSP_008350Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225124 mRNA. Translation: AAP57518.1.
AY225125 mRNA. Translation: AAP57519.1.
AB040961 mRNA. Translation: BAA96052.1. Different initiation.
AK023924 mRNA. Translation: BAB14727.1.
AC005522 Genomic DNA. Translation: AAP21881.1.
AC007078 Genomic DNA. No translation available.
BC008856 mRNA. Translation: AAH08856.1.
BC018555 mRNA. Translation: AAH18555.1.
BC026059 mRNA. Translation: AAH26059.1.
BC093079 mRNA. Translation: AAH93079.1.
CCDSiCCDS43605.1. [Q86UW9-2]
CCDS5587.1. [Q86UW9-1]
RefSeqiNP_001096064.1. NM_001102594.1. [Q86UW9-1]
NP_001096065.1. NM_001102595.1. [Q86UW9-1]
NP_001096066.1. NM_001102596.1. [Q86UW9-2]
NP_065943.2. NM_020892.2. [Q86UW9-1]
XP_005250188.1. XM_005250131.1. [Q86UW9-1]
XP_005250189.1. XM_005250132.1. [Q86UW9-1]
XP_005250191.1. XM_005250134.1. [Q86UW9-2]
XP_006715909.1. XM_006715846.1. [Q86UW9-1]
UniGeneiHs.187058.

Genome annotation databases

EnsembliENST00000324432; ENSP00000322885; ENSG00000091073. [Q86UW9-1]
ENST00000413936; ENSP00000390218; ENSG00000091073. [Q86UW9-1]
ENST00000430490; ENSP00000411986; ENSG00000091073. [Q86UW9-1]
ENST00000446820; ENSP00000392545; ENSG00000091073. [Q86UW9-2]
GeneIDi113878.
KEGGihsa:113878.
UCSCiuc003uff.4. human. [Q86UW9-1]
uc003ufj.4. human. [Q86UW9-2]

Polymorphism databases

DMDMi68067880.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225124 mRNA. Translation: AAP57518.1 .
AY225125 mRNA. Translation: AAP57519.1 .
AB040961 mRNA. Translation: BAA96052.1 . Different initiation.
AK023924 mRNA. Translation: BAB14727.1 .
AC005522 Genomic DNA. Translation: AAP21881.1 .
AC007078 Genomic DNA. No translation available.
BC008856 mRNA. Translation: AAH08856.1 .
BC018555 mRNA. Translation: AAH18555.1 .
BC026059 mRNA. Translation: AAH26059.1 .
BC093079 mRNA. Translation: AAH93079.1 .
CCDSi CCDS43605.1. [Q86UW9-2 ]
CCDS5587.1. [Q86UW9-1 ]
RefSeqi NP_001096064.1. NM_001102594.1. [Q86UW9-1 ]
NP_001096065.1. NM_001102595.1. [Q86UW9-1 ]
NP_001096066.1. NM_001102596.1. [Q86UW9-2 ]
NP_065943.2. NM_020892.2. [Q86UW9-1 ]
XP_005250188.1. XM_005250131.1. [Q86UW9-1 ]
XP_005250189.1. XM_005250132.1. [Q86UW9-1 ]
XP_005250191.1. XM_005250134.1. [Q86UW9-2 ]
XP_006715909.1. XM_006715846.1. [Q86UW9-1 ]
UniGenei Hs.187058.

3D structure databases

ProteinModelPortali Q86UW9.
SMRi Q86UW9. Positions 18-182, 392-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125266. 16 interactions.
IntActi Q86UW9. 18 interactions.
MINTi MINT-1436106.
STRINGi 9606.ENSP00000322885.

PTM databases

PhosphoSitei Q86UW9.

Polymorphism databases

DMDMi 68067880.

Proteomic databases

MaxQBi Q86UW9.
PaxDbi Q86UW9.
PRIDEi Q86UW9.

Protocols and materials databases

DNASUi 113878.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324432 ; ENSP00000322885 ; ENSG00000091073 . [Q86UW9-1 ]
ENST00000413936 ; ENSP00000390218 ; ENSG00000091073 . [Q86UW9-1 ]
ENST00000430490 ; ENSP00000411986 ; ENSG00000091073 . [Q86UW9-1 ]
ENST00000446820 ; ENSP00000392545 ; ENSG00000091073 . [Q86UW9-2 ]
GeneIDi 113878.
KEGGi hsa:113878.
UCSCi uc003uff.4. human. [Q86UW9-1 ]
uc003ufj.4. human. [Q86UW9-2 ]

Organism-specific databases

CTDi 113878.
GeneCardsi GC07P076090.
HGNCi HGNC:15973. DTX2.
HPAi HPA042931.
MIMi 613141. gene.
neXtProti NX_Q86UW9.
PharmGKBi PA27515.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0323.
GeneTreei ENSGT00440000035370.
HOGENOMi HOG000007352.
HOVERGENi HBG007213.
InParanoidi Q86UW9.
KOi K06058.
OMAi QPQGKME.
OrthoDBi EOG7J17ZB.
PhylomeDBi Q86UW9.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.

Miscellaneous databases

ChiTaRSi DTX2. human.
GeneWikii DTX2.
GenomeRNAii 113878.
NextBioi 78930.
PROi Q86UW9.
SOURCEi Search...

Gene expression databases

Bgeei Q86UW9.
CleanExi HS_DTX2.
ExpressionAtlasi Q86UW9. baseline and differential.
Genevestigatori Q86UW9.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF02825. WWE. 2 hits.
PF00097. zf-C3HC4. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view ]
PROSITEi PS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity."
    Takeyama K., Aguiar R.C.T., Gu L., He C., Freeman G.J., Kutok J.L., Aster J.C., Shipp M.A.
    J. Biol. Chem. 278:21930-21937(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), VARIANT GLU-384, SUBUNIT, IN VITRO UBIQUITIN LIGASE ACTIVITY.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-384 AND ALA-421.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-421.
    Tissue: Thyroid.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-384.
    Tissue: Brain, Lymph and Muscle.
  6. Cited for: SUBCELLULAR LOCATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDTX2_HUMAN
AccessioniPrimary (citable) accession number: Q86UW9
Secondary accession number(s): Q6XM87
, Q6XM88, Q96H69, Q9H890, Q9P200
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3