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Q86UW9

- DTX2_HUMAN

UniProt

Q86UW9 - DTX2_HUMAN

Protein

Probable E3 ubiquitin-protein ligase DTX2

Gene

DTX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri412 – 47362RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. Notch signaling pathway Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Notch signaling pathway, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable E3 ubiquitin-protein ligase DTX2 (EC:6.3.2.-)
    Alternative name(s):
    Protein deltex-2
    Short name:
    Deltex2
    Short name:
    hDTX2
    RING finger protein 58
    Gene namesi
    Name:DTX2
    Synonyms:KIAA1528, RNF58
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:15973. DTX2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Predominantly cytoplasmic. Partially nuclear.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear membrane Source: HPA
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27515.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 622622Probable E3 ubiquitin-protein ligase DTX2PRO_0000219083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei249 – 2491N6-acetyllysine1 Publication
    Modified residuei360 – 3601Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ86UW9.
    PaxDbiQ86UW9.
    PRIDEiQ86UW9.

    PTM databases

    PhosphoSiteiQ86UW9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86UW9.
    BgeeiQ86UW9.
    CleanExiHS_DTX2.
    GenevestigatoriQ86UW9.

    Organism-specific databases

    HPAiHPA042931.

    Interactioni

    Subunit structurei

    Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UBE2D4Q9Y2X83EBI-740376,EBI-745527

    Protein-protein interaction databases

    BioGridi125266. 15 interactions.
    IntActiQ86UW9. 18 interactions.
    MINTiMINT-1436106.
    STRINGi9606.ENSP00000322885.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UW9.
    SMRiQ86UW9. Positions 18-182, 392-614.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 9790WWE 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 17477WWE 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.By similarity

    Sequence similaritiesi

    Belongs to the Deltex family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 2 WWE domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri412 – 47362RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0323.
    HOGENOMiHOG000007352.
    HOVERGENiHBG007213.
    InParanoidiQ86UW9.
    KOiK06058.
    OMAiQPQGKME.
    OrthoDBiEOG7J17ZB.
    PhylomeDBiQ86UW9.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR004170. WWE-dom.
    IPR018123. WWE-dom_subgr.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF02825. WWE. 2 hits.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00678. WWE. 2 hits.
    [Graphical view]
    PROSITEiPS50918. WWE. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86UW9-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMAPSPSLV QVYTSPAAVA VWEWQDGLGT WHPYSATVCS FIEQQFVQQK    50
    GQRFGLGSLA HSIPLGQADP SLAPYIIDLP SWTQFRQDTG TMRAVRRHLF 100
    PQHSAPGRGV VWEWLSDDGS WTAYEASVCD YLEQQVARGN QLVDLAPLGY 150
    NYTVNYTTHT QTNKTSSFCR SVRRQAGPPY PVTTIIAPPG HTGVACSCHQ 200
    CLSGSRTGPV SGRYRHSMTN LPAYPVPQHP PHRTASVFGT HQAFAPYNKP 250
    SLSGARSAPR LNTTNAWGAA PPSLGSQPLY RSSLSHLGPQ HLPPGSSTSG 300
    AVSASLPSGP SSSPGSVPAT VPMQMPKPSR VQQALAGMTS VLMSAIGLPV 350
    CLSRAPQPTS PPASRLASKS HGSVKRLRKM SVKGATPKPE PEPEQVIKNY 400
    TEELKVPPDE DCIICMEKLS TASGYSDVTD SKAIGSLAVG HLTKCSHAFH 450
    LLCLLAMYCN GNKDGSLQCP SCKTIYGEKT GTQPQGKMEV LRFQMSLPGH 500
    EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE 550
    LLKVAWKRRL IFTVGTSSTT GETDTVVWNE IHHKTEMDRN ITGHGYPDPN 600
    YLQNVLAELA AQGVTEDCLE QQ 622
    Length:622
    Mass (Da):67,246
    Last modified:June 21, 2005 - v3
    Checksum:iABE1398204F2273A
    GO
    Isoform 2 (identifier: Q86UW9-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         337-383: Missing.

    Show »
    Length:575
    Mass (Da):62,344
    Checksum:i449202FB53C026B3
    GO

    Sequence cautioni

    The sequence BAA96052.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti94 – 941A → T.
    Corresponds to variant rs2462312 [ dbSNP | Ensembl ].
    VAR_016920
    Natural varianti384 – 3841G → E.3 Publications
    Corresponds to variant rs1638152 [ dbSNP | Ensembl ].
    VAR_016921
    Natural varianti421 – 4211T → A.2 Publications
    Corresponds to variant rs6979487 [ dbSNP | Ensembl ].
    VAR_016922

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei337 – 38347Missing in isoform 2. CuratedVSP_008350Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY225124 mRNA. Translation: AAP57518.1.
    AY225125 mRNA. Translation: AAP57519.1.
    AB040961 mRNA. Translation: BAA96052.1. Different initiation.
    AK023924 mRNA. Translation: BAB14727.1.
    AC005522 Genomic DNA. Translation: AAP21881.1.
    AC007078 Genomic DNA. No translation available.
    BC008856 mRNA. Translation: AAH08856.1.
    BC018555 mRNA. Translation: AAH18555.1.
    BC026059 mRNA. Translation: AAH26059.1.
    BC093079 mRNA. Translation: AAH93079.1.
    CCDSiCCDS43605.1. [Q86UW9-2]
    CCDS5587.1. [Q86UW9-1]
    RefSeqiNP_001096064.1. NM_001102594.1. [Q86UW9-1]
    NP_001096065.1. NM_001102595.1. [Q86UW9-1]
    NP_001096066.1. NM_001102596.1. [Q86UW9-2]
    NP_065943.2. NM_020892.2. [Q86UW9-1]
    XP_005250188.1. XM_005250131.1. [Q86UW9-1]
    XP_005250189.1. XM_005250132.1. [Q86UW9-1]
    XP_005250191.1. XM_005250134.1. [Q86UW9-2]
    XP_006715909.1. XM_006715846.1. [Q86UW9-1]
    UniGeneiHs.187058.

    Genome annotation databases

    EnsembliENST00000324432; ENSP00000322885; ENSG00000091073. [Q86UW9-1]
    ENST00000413936; ENSP00000390218; ENSG00000091073. [Q86UW9-1]
    ENST00000430490; ENSP00000411986; ENSG00000091073. [Q86UW9-1]
    ENST00000446820; ENSP00000392545; ENSG00000091073. [Q86UW9-2]
    GeneIDi113878.
    KEGGihsa:113878.
    UCSCiuc003uff.4. human. [Q86UW9-1]
    uc003ufj.4. human. [Q86UW9-2]

    Polymorphism databases

    DMDMi68067880.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY225124 mRNA. Translation: AAP57518.1 .
    AY225125 mRNA. Translation: AAP57519.1 .
    AB040961 mRNA. Translation: BAA96052.1 . Different initiation.
    AK023924 mRNA. Translation: BAB14727.1 .
    AC005522 Genomic DNA. Translation: AAP21881.1 .
    AC007078 Genomic DNA. No translation available.
    BC008856 mRNA. Translation: AAH08856.1 .
    BC018555 mRNA. Translation: AAH18555.1 .
    BC026059 mRNA. Translation: AAH26059.1 .
    BC093079 mRNA. Translation: AAH93079.1 .
    CCDSi CCDS43605.1. [Q86UW9-2 ]
    CCDS5587.1. [Q86UW9-1 ]
    RefSeqi NP_001096064.1. NM_001102594.1. [Q86UW9-1 ]
    NP_001096065.1. NM_001102595.1. [Q86UW9-1 ]
    NP_001096066.1. NM_001102596.1. [Q86UW9-2 ]
    NP_065943.2. NM_020892.2. [Q86UW9-1 ]
    XP_005250188.1. XM_005250131.1. [Q86UW9-1 ]
    XP_005250189.1. XM_005250132.1. [Q86UW9-1 ]
    XP_005250191.1. XM_005250134.1. [Q86UW9-2 ]
    XP_006715909.1. XM_006715846.1. [Q86UW9-1 ]
    UniGenei Hs.187058.

    3D structure databases

    ProteinModelPortali Q86UW9.
    SMRi Q86UW9. Positions 18-182, 392-614.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125266. 15 interactions.
    IntActi Q86UW9. 18 interactions.
    MINTi MINT-1436106.
    STRINGi 9606.ENSP00000322885.

    PTM databases

    PhosphoSitei Q86UW9.

    Polymorphism databases

    DMDMi 68067880.

    Proteomic databases

    MaxQBi Q86UW9.
    PaxDbi Q86UW9.
    PRIDEi Q86UW9.

    Protocols and materials databases

    DNASUi 113878.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324432 ; ENSP00000322885 ; ENSG00000091073 . [Q86UW9-1 ]
    ENST00000413936 ; ENSP00000390218 ; ENSG00000091073 . [Q86UW9-1 ]
    ENST00000430490 ; ENSP00000411986 ; ENSG00000091073 . [Q86UW9-1 ]
    ENST00000446820 ; ENSP00000392545 ; ENSG00000091073 . [Q86UW9-2 ]
    GeneIDi 113878.
    KEGGi hsa:113878.
    UCSCi uc003uff.4. human. [Q86UW9-1 ]
    uc003ufj.4. human. [Q86UW9-2 ]

    Organism-specific databases

    CTDi 113878.
    GeneCardsi GC07P076090.
    HGNCi HGNC:15973. DTX2.
    HPAi HPA042931.
    MIMi 613141. gene.
    neXtProti NX_Q86UW9.
    PharmGKBi PA27515.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0323.
    HOGENOMi HOG000007352.
    HOVERGENi HBG007213.
    InParanoidi Q86UW9.
    KOi K06058.
    OMAi QPQGKME.
    OrthoDBi EOG7J17ZB.
    PhylomeDBi Q86UW9.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.

    Miscellaneous databases

    ChiTaRSi DTX2. human.
    GeneWikii DTX2.
    GenomeRNAii 113878.
    NextBioi 78930.
    PROi Q86UW9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UW9.
    Bgeei Q86UW9.
    CleanExi HS_DTX2.
    Genevestigatori Q86UW9.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR004170. WWE-dom.
    IPR018123. WWE-dom_subgr.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF02825. WWE. 2 hits.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00678. WWE. 2 hits.
    [Graphical view ]
    PROSITEi PS50918. WWE. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity."
      Takeyama K., Aguiar R.C.T., Gu L., He C., Freeman G.J., Kutok J.L., Aster J.C., Shipp M.A.
      J. Biol. Chem. 278:21930-21937(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), VARIANT GLU-384, SUBUNIT, IN VITRO UBIQUITIN LIGASE ACTIVITY.
    2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-384 AND ALA-421.
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-421.
      Tissue: Thyroid.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-384.
      Tissue: Brain, Lymph and Muscle.
    6. Cited for: SUBCELLULAR LOCATION.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDTX2_HUMAN
    AccessioniPrimary (citable) accession number: Q86UW9
    Secondary accession number(s): Q6XM87
    , Q6XM88, Q96H69, Q9H890, Q9P200
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3