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Q86UW8

- HPLN4_HUMAN

UniProt

Q86UW8 - HPLN4_HUMAN

Protein

Hyaluronan and proteoglycan link protein 4

Gene

HAPLN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Binds to hyaluronic acid and may be involved in formation of the extracellular matrix.By similarity

    GO - Molecular functioni

    1. hyaluronic acid binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: InterPro

    Keywords - Ligandi

    Hyaluronic acid

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronan and proteoglycan link protein 4
    Alternative name(s):
    Brain link protein 2
    Gene namesi
    Name:HAPLN4
    Synonyms:BRAL2, KIAA1926
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:31357. HAPLN4.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134886721.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 402373Hyaluronan and proteoglycan link protein 4Sequence AnalysisPRO_0000013192Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi68 ↔ 143By similarity
    Glycosylationi132 – 1321N-linked (GlcNAc...)Curated
    Disulfide bondi185 ↔ 266By similarity
    Disulfide bondi209 ↔ 230By similarity
    Disulfide bondi293 ↔ 363By similarity
    Disulfide bondi318 ↔ 339By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ86UW8.
    PaxDbiQ86UW8.
    PRIDEiQ86UW8.

    PTM databases

    PhosphoSiteiQ86UW8.

    Expressioni

    Tissue specificityi

    Expressed predominantly in brain.1 Publication

    Gene expression databases

    CleanExiHS_HAPLN4.
    GenevestigatoriQ86UW8.

    Organism-specific databases

    HPAiHPA055856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UW8.
    SMRiQ86UW8. Positions 55-161, 164-267, 275-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 161116Ig-like C2-typeAdd
    BLAST
    Domaini163 – 268106Link 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini273 – 36593Link 2CuratedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HAPLN family.Curated
    Contains 2 Link domains.CuratedPROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG42970.
    HOGENOMiHOG000234353.
    HOVERGENiHBG051922.
    InParanoidiQ86UW8.
    KOiK06853.
    OMAiKWTKVTD.
    PhylomeDBiQ86UW8.
    TreeFamiTF332134.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.100.10. 2 hits.
    InterProiIPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR000538. Link.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view]
    PRINTSiPR01265. LINKMODULE.
    SMARTiSM00408. IGc2. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 2 hits.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS01241. LINK_1. 1 hit.
    PS50963. LINK_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86UW8-1 [UniParc]FASTAAdd to Basket

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    MVCARAALGP GALWAAAWGV LLLTAPAGAQ RGRKKVVHVL EGESGSVVVQ    50
    TAPGQVVSHR GGTIVLPCRY HYEAAAHGHD GVRLKWTKVV DPLAFTDVFV 100
    ALGPQHRAFG SYRGRAELQG DGPGDASLVL RNVTLQDYGR YECEVTNELE 150
    DDAGMVKLDL EGVVFPYHPR GGRYKLTFAE AQRACAEQDG ILASAEQLHA 200
    AWRDGLDWCN AGWLRDGSVQ YPVNRPREPC GGLGGTGSAG GGGDANGGLR 250
    NYGYRHNAEE RYDAFCFTSN LPGRVFFLKP LRPVPFSGAA RACAARGAAV 300
    AKVGQLFAAW KLQLLDRCTA GWLADGSARY PIVNPRARCG GRRPGVRSLG 350
    FPDATRRLFG VYCYRAPGAP DPAPGGWGWG WAGGGGWAGG ARDPAAWTPL 400
    HV 402
    Length:402
    Mass (Da):42,801
    Last modified:June 1, 2003 - v1
    Checksum:iB1B6CE2098244124
    GO

    Sequence cautioni

    The sequence BAB67819.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY262756 mRNA. Translation: AAP22048.1.
    AB107883 mRNA. Translation: BAC79077.1.
    AB067513 mRNA. Translation: BAB67819.1. Different initiation.
    CH471106 Genomic DNA. Translation: EAW84804.1.
    BC142644 mRNA. Translation: AAI42645.1.
    BC142698 mRNA. Translation: AAI42699.1.
    CCDSiCCDS12398.1.
    RefSeqiNP_075378.1. NM_023002.2.
    UniGeneiHs.367829.

    Genome annotation databases

    EnsembliENST00000291481; ENSP00000291481; ENSG00000187664.
    GeneIDi404037.
    KEGGihsa:404037.
    UCSCiuc002nmb.3. human.

    Polymorphism databases

    DMDMi47605684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY262756 mRNA. Translation: AAP22048.1 .
    AB107883 mRNA. Translation: BAC79077.1 .
    AB067513 mRNA. Translation: BAB67819.1 . Different initiation.
    CH471106 Genomic DNA. Translation: EAW84804.1 .
    BC142644 mRNA. Translation: AAI42645.1 .
    BC142698 mRNA. Translation: AAI42699.1 .
    CCDSi CCDS12398.1.
    RefSeqi NP_075378.1. NM_023002.2.
    UniGenei Hs.367829.

    3D structure databases

    ProteinModelPortali Q86UW8.
    SMRi Q86UW8. Positions 55-161, 164-267, 275-366.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q86UW8.

    Polymorphism databases

    DMDMi 47605684.

    Proteomic databases

    MaxQBi Q86UW8.
    PaxDbi Q86UW8.
    PRIDEi Q86UW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291481 ; ENSP00000291481 ; ENSG00000187664 .
    GeneIDi 404037.
    KEGGi hsa:404037.
    UCSCi uc002nmb.3. human.

    Organism-specific databases

    CTDi 404037.
    GeneCardsi GC19M019366.
    HGNCi HGNC:31357. HAPLN4.
    HPAi HPA055856.
    neXtProti NX_Q86UW8.
    PharmGKBi PA134886721.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42970.
    HOGENOMi HOG000234353.
    HOVERGENi HBG051922.
    InParanoidi Q86UW8.
    KOi K06853.
    OMAi KWTKVTD.
    PhylomeDBi Q86UW8.
    TreeFami TF332134.

    Miscellaneous databases

    GenomeRNAii 404037.
    NextBioi 107801.
    PROi Q86UW8.

    Gene expression databases

    CleanExi HS_HAPLN4.
    Genevestigatori Q86UW8.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.100.10. 2 hits.
    InterProi IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR000538. Link.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view ]
    PRINTSi PR01265. LINKMODULE.
    SMARTi SM00408. IGc2. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 2 hits.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS01241. LINK_1. 1 hit.
    PS50963. LINK_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links."
      Spicer A.P., Joo A., Bowling R.A. Jr.
      J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets."
      Bekku Y., Su W.-D., Hirakawa S., Faessler R., Ohtsuka A., Kang J.S., Sanders J., Murakami T., Ninomiya Y., Oohashi T.
      Mol. Cell. Neurosci. 24:148-159(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiHPLN4_HUMAN
    AccessioniPrimary (citable) accession number: Q86UW8
    Secondary accession number(s): A5PKW5, Q96PW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3