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Protein

Hyaluronan and proteoglycan link protein 4

Gene

HAPLN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to hyaluronic acid and may be involved in formation of the extracellular matrix.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 4
Alternative name(s):
Brain link protein 2
Gene namesi
Name:HAPLN4
Synonyms:BRAL2, KIAA1926
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000187664.8
HGNCiHGNC:31357 HAPLN4
neXtProtiNX_Q86UW8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi404037
PharmGKBiPA134886721

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMutaiHAPLN4
DMDMi47605684

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001319230 – 402Hyaluronan and proteoglycan link protein 4Sequence analysisAdd BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 143By similarity
Glycosylationi132N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi185 ↔ 266By similarity
Disulfide bondi209 ↔ 230By similarity
Disulfide bondi293 ↔ 363By similarity
Disulfide bondi318 ↔ 339By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ86UW8
PaxDbiQ86UW8
PeptideAtlasiQ86UW8
PRIDEiQ86UW8

PTM databases

iPTMnetiQ86UW8
PhosphoSitePlusiQ86UW8

Expressioni

Tissue specificityi

Expressed predominantly in brain.1 Publication

Gene expression databases

BgeeiENSG00000187664
CleanExiHS_HAPLN4
GenevisibleiQ86UW8 HS

Organism-specific databases

HPAiHPA055856

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000291481

Structurei

3D structure databases

ProteinModelPortaliQ86UW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 161Ig-like C2-typeAdd BLAST116
Domaini163 – 268Link 1PROSITE-ProRule annotationCuratedAdd BLAST106
Domaini273 – 365Link 2PROSITE-ProRule annotationCuratedAdd BLAST93

Sequence similaritiesi

Belongs to the HAPLN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IENV Eukaryota
ENOG411150M LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000234353
HOVERGENiHBG051922
InParanoidiQ86UW8
KOiK06853
OMAiDDTGMVK
OrthoDBiEOG091G09EL
PhylomeDBiQ86UW8
TreeFamiTF332134

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.100.10, 2 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000538 Link_dom
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCARAALGP GALWAAAWGV LLLTAPAGAQ RGRKKVVHVL EGESGSVVVQ
60 70 80 90 100
TAPGQVVSHR GGTIVLPCRY HYEAAAHGHD GVRLKWTKVV DPLAFTDVFV
110 120 130 140 150
ALGPQHRAFG SYRGRAELQG DGPGDASLVL RNVTLQDYGR YECEVTNELE
160 170 180 190 200
DDAGMVKLDL EGVVFPYHPR GGRYKLTFAE AQRACAEQDG ILASAEQLHA
210 220 230 240 250
AWRDGLDWCN AGWLRDGSVQ YPVNRPREPC GGLGGTGSAG GGGDANGGLR
260 270 280 290 300
NYGYRHNAEE RYDAFCFTSN LPGRVFFLKP LRPVPFSGAA RACAARGAAV
310 320 330 340 350
AKVGQLFAAW KLQLLDRCTA GWLADGSARY PIVNPRARCG GRRPGVRSLG
360 370 380 390 400
FPDATRRLFG VYCYRAPGAP DPAPGGWGWG WAGGGGWAGG ARDPAAWTPL

HV
Length:402
Mass (Da):42,801
Last modified:June 1, 2003 - v1
Checksum:iB1B6CE2098244124
GO

Sequence cautioni

The sequence BAB67819 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262756 mRNA Translation: AAP22048.1
AB107883 mRNA Translation: BAC79077.1
AB067513 mRNA Translation: BAB67819.1 Different initiation.
CH471106 Genomic DNA Translation: EAW84804.1
BC142644 mRNA Translation: AAI42645.1
BC142698 mRNA Translation: AAI42699.1
CCDSiCCDS12398.1
RefSeqiNP_075378.1, NM_023002.2
UniGeneiHs.367829

Genome annotation databases

EnsembliENST00000291481; ENSP00000291481; ENSG00000187664
GeneIDi404037
KEGGihsa:404037
UCSCiuc002nmb.5 human

Similar proteinsi

Entry informationi

Entry nameiHPLN4_HUMAN
AccessioniPrimary (citable) accession number: Q86UW8
Secondary accession number(s): A5PKW5, Q96PW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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