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Q86UW8 (HPLN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronan and proteoglycan link protein 4
Alternative name(s):
Brain link protein 2
Gene names
Name:HAPLN4
Synonyms:BRAL2, KIAA1926
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to hyaluronic acid and may be involved in formation of the extracellular matrix By similarity. UniProtKB Q80WM4

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Expressed predominantly in brain. Ref.1

Sequence similarities

Belongs to the HAPLN family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 2 Link domains.

Sequence caution

The sequence BAB67819.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   DomainImmunoglobulin domain
Repeat
Signal
   LigandHyaluronic acid
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhyaluronic acid binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 402373Hyaluronan and proteoglycan link protein 4
PRO_0000013192

Regions

Domain46 – 161116Ig-like C2-type
Domain163 – 268106Link 1
Domain273 – 36593Link 2

Amino acid modifications

Glycosylation1321N-linked (GlcNAc...) Potential
Disulfide bond68 ↔ 143 By similarity UniProtKB P03994
Disulfide bond185 ↔ 266 By similarity UniProtKB P03994
Disulfide bond209 ↔ 230 By similarity UniProtKB P03994
Disulfide bond293 ↔ 363 By similarity UniProtKB P03994
Disulfide bond318 ↔ 339 By similarity UniProtKB P03994

Sequences

Sequence LengthMass (Da)Tools
Q86UW8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B1B6CE2098244124

FASTA40242,801
        10         20         30         40         50         60 
MVCARAALGP GALWAAAWGV LLLTAPAGAQ RGRKKVVHVL EGESGSVVVQ TAPGQVVSHR 

        70         80         90        100        110        120 
GGTIVLPCRY HYEAAAHGHD GVRLKWTKVV DPLAFTDVFV ALGPQHRAFG SYRGRAELQG 

       130        140        150        160        170        180 
DGPGDASLVL RNVTLQDYGR YECEVTNELE DDAGMVKLDL EGVVFPYHPR GGRYKLTFAE 

       190        200        210        220        230        240 
AQRACAEQDG ILASAEQLHA AWRDGLDWCN AGWLRDGSVQ YPVNRPREPC GGLGGTGSAG 

       250        260        270        280        290        300 
GGGDANGGLR NYGYRHNAEE RYDAFCFTSN LPGRVFFLKP LRPVPFSGAA RACAARGAAV 

       310        320        330        340        350        360 
AKVGQLFAAW KLQLLDRCTA GWLADGSARY PIVNPRARCG GRRPGVRSLG FPDATRRLFG 

       370        380        390        400 
VYCYRAPGAP DPAPGGWGWG WAGGGGWAGG ARDPAAWTPL HV 

« Hide

References

« Hide 'large scale' references
[1]"A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links."
Spicer A.P., Joo A., Bowling R.A. Jr.
J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets."
Bekku Y., Su W.-D., Hirakawa S., Faessler R., Ohtsuka A., Kang J.S., Sanders J., Murakami T., Ninomiya Y., Oohashi T.
Mol. Cell. Neurosci. 24:148-159(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY262756 mRNA. Translation: AAP22048.1.
AB107883 mRNA. Translation: BAC79077.1.
AB067513 mRNA. Translation: BAB67819.1. Different initiation.
CH471106 Genomic DNA. Translation: EAW84804.1.
BC142644 mRNA. Translation: AAI42645.1.
BC142698 mRNA. Translation: AAI42699.1.
RefSeqNP_075378.1. NM_023002.2.
UniGeneHs.367829.

3D structure databases

ProteinModelPortalQ86UW8.
SMRQ86UW8. Positions 55-161, 164-267, 275-366.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ86UW8.

Polymorphism databases

DMDM47605684.

Proteomic databases

PaxDbQ86UW8.
PRIDEQ86UW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000291481; ENSP00000291481; ENSG00000187664.
GeneID404037.
KEGGhsa:404037.
UCSCuc002nmb.3. human.

Organism-specific databases

CTD404037.
GeneCardsGC19M019366.
HGNCHGNC:31357. HAPLN4.
HPAHPA055856.
neXtProtNX_Q86UW8.
PharmGKBPA134886721.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42970.
HOGENOMHOG000234353.
HOVERGENHBG051922.
InParanoidQ86UW8.
KOK06853.
OMAKWTKVTD.
PhylomeDBQ86UW8.
TreeFamTF332134.

Gene expression databases

CleanExHS_HAPLN4.
GenevestigatorQ86UW8.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSPR01265. LINKMODULE.
SMARTSM00408. IGc2. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMSSF56436. SSF56436. 2 hits.
PROSITEPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi404037.
NextBio107801.
PROQ86UW8.

Entry information

Entry nameHPLN4_HUMAN
AccessionPrimary (citable) accession number: Q86UW8
Secondary accession number(s): A5PKW5, Q96PW2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: March 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM