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Protein

Hyaluronan and proteoglycan link protein 4

Gene

HAPLN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to hyaluronic acid and may be involved in formation of the extracellular matrix.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 4
Alternative name(s):
Brain link protein 2
Gene namesi
Name:HAPLN4
Synonyms:BRAL2, KIAA1926
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:31357. HAPLN4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886721.

Chemistry

DrugBankiDB08818. Hyaluronan.

Polymorphism and mutation databases

BioMutaiHAPLN4.
DMDMi47605684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 402373Hyaluronan and proteoglycan link protein 4Sequence AnalysisPRO_0000013192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 143By similarity
Glycosylationi132 – 1321N-linked (GlcNAc...)Curated
Disulfide bondi185 ↔ 266By similarity
Disulfide bondi209 ↔ 230By similarity
Disulfide bondi293 ↔ 363By similarity
Disulfide bondi318 ↔ 339By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ86UW8.
PaxDbiQ86UW8.
PRIDEiQ86UW8.

PTM databases

PhosphoSiteiQ86UW8.

Expressioni

Tissue specificityi

Expressed predominantly in brain.1 Publication

Gene expression databases

CleanExiHS_HAPLN4.
GenevisibleiQ86UW8. HS.

Organism-specific databases

HPAiHPA055856.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000291481.

Structurei

3D structure databases

ProteinModelPortaliQ86UW8.
SMRiQ86UW8. Positions 47-162, 164-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 161116Ig-like C2-typeAdd
BLAST
Domaini163 – 268106Link 1PROSITE-ProRule annotationCuratedAdd
BLAST
Domaini273 – 36593Link 2PROSITE-ProRule annotationCuratedAdd
BLAST

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.PROSITE-ProRule annotationCurated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG42970.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ86UW8.
KOiK06853.
OMAiKWTKVTD.
PhylomeDBiQ86UW8.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00408. IGc2. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCARAALGP GALWAAAWGV LLLTAPAGAQ RGRKKVVHVL EGESGSVVVQ
60 70 80 90 100
TAPGQVVSHR GGTIVLPCRY HYEAAAHGHD GVRLKWTKVV DPLAFTDVFV
110 120 130 140 150
ALGPQHRAFG SYRGRAELQG DGPGDASLVL RNVTLQDYGR YECEVTNELE
160 170 180 190 200
DDAGMVKLDL EGVVFPYHPR GGRYKLTFAE AQRACAEQDG ILASAEQLHA
210 220 230 240 250
AWRDGLDWCN AGWLRDGSVQ YPVNRPREPC GGLGGTGSAG GGGDANGGLR
260 270 280 290 300
NYGYRHNAEE RYDAFCFTSN LPGRVFFLKP LRPVPFSGAA RACAARGAAV
310 320 330 340 350
AKVGQLFAAW KLQLLDRCTA GWLADGSARY PIVNPRARCG GRRPGVRSLG
360 370 380 390 400
FPDATRRLFG VYCYRAPGAP DPAPGGWGWG WAGGGGWAGG ARDPAAWTPL

HV
Length:402
Mass (Da):42,801
Last modified:June 1, 2003 - v1
Checksum:iB1B6CE2098244124
GO

Sequence cautioni

The sequence BAB67819.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262756 mRNA. Translation: AAP22048.1.
AB107883 mRNA. Translation: BAC79077.1.
AB067513 mRNA. Translation: BAB67819.1. Different initiation.
CH471106 Genomic DNA. Translation: EAW84804.1.
BC142644 mRNA. Translation: AAI42645.1.
BC142698 mRNA. Translation: AAI42699.1.
CCDSiCCDS12398.1.
RefSeqiNP_075378.1. NM_023002.2.
UniGeneiHs.367829.

Genome annotation databases

EnsembliENST00000291481; ENSP00000291481; ENSG00000187664.
GeneIDi404037.
KEGGihsa:404037.
UCSCiuc002nmb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262756 mRNA. Translation: AAP22048.1.
AB107883 mRNA. Translation: BAC79077.1.
AB067513 mRNA. Translation: BAB67819.1. Different initiation.
CH471106 Genomic DNA. Translation: EAW84804.1.
BC142644 mRNA. Translation: AAI42645.1.
BC142698 mRNA. Translation: AAI42699.1.
CCDSiCCDS12398.1.
RefSeqiNP_075378.1. NM_023002.2.
UniGeneiHs.367829.

3D structure databases

ProteinModelPortaliQ86UW8.
SMRiQ86UW8. Positions 47-162, 164-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000291481.

Chemistry

DrugBankiDB08818. Hyaluronan.

PTM databases

PhosphoSiteiQ86UW8.

Polymorphism and mutation databases

BioMutaiHAPLN4.
DMDMi47605684.

Proteomic databases

MaxQBiQ86UW8.
PaxDbiQ86UW8.
PRIDEiQ86UW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291481; ENSP00000291481; ENSG00000187664.
GeneIDi404037.
KEGGihsa:404037.
UCSCiuc002nmb.3. human.

Organism-specific databases

CTDi404037.
GeneCardsiGC19M019366.
HGNCiHGNC:31357. HAPLN4.
HPAiHPA055856.
neXtProtiNX_Q86UW8.
PharmGKBiPA134886721.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42970.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ86UW8.
KOiK06853.
OMAiKWTKVTD.
PhylomeDBiQ86UW8.
TreeFamiTF332134.

Miscellaneous databases

GenomeRNAii404037.
NextBioi107801.
PROiQ86UW8.

Gene expression databases

CleanExiHS_HAPLN4.
GenevisibleiQ86UW8. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00408. IGc2. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links."
    Spicer A.P., Joo A., Bowling R.A. Jr.
    J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets."
    Bekku Y., Su W.-D., Hirakawa S., Faessler R., Ohtsuka A., Kang J.S., Sanders J., Murakami T., Ninomiya Y., Oohashi T.
    Mol. Cell. Neurosci. 24:148-159(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHPLN4_HUMAN
AccessioniPrimary (citable) accession number: Q86UW8
Secondary accession number(s): A5PKW5, Q96PW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.