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Q86UW8

- HPLN4_HUMAN

UniProt

Q86UW8 - HPLN4_HUMAN

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Protein
Hyaluronan and proteoglycan link protein 4
Gene
HAPLN4, BRAL2, KIAA1926
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to hyaluronic acid and may be involved in formation of the extracellular matrix By similarity.By similarity

GO - Molecular functioni

  1. hyaluronic acid binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 4
Alternative name(s):
Brain link protein 2
Gene namesi
Name:HAPLN4
Synonyms:BRAL2, KIAA1926
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:31357. HAPLN4.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 402373Hyaluronan and proteoglycan link protein 4
PRO_0000013192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 143 By similarityBy similarity
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi185 ↔ 266 By similarityBy similarity
Disulfide bondi209 ↔ 230 By similarityBy similarity
Disulfide bondi293 ↔ 363 By similarityBy similarity
Disulfide bondi318 ↔ 339 By similarityBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ86UW8.
PaxDbiQ86UW8.
PRIDEiQ86UW8.

PTM databases

PhosphoSiteiQ86UW8.

Expressioni

Tissue specificityi

Expressed predominantly in brain.1 Publication

Gene expression databases

CleanExiHS_HAPLN4.
GenevestigatoriQ86UW8.

Organism-specific databases

HPAiHPA055856.

Structurei

3D structure databases

ProteinModelPortaliQ86UW8.
SMRiQ86UW8. Positions 55-161, 164-267, 275-366.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 161116Ig-like C2-type
Add
BLAST
Domaini163 – 268106Link 1
Add
BLAST
Domaini273 – 36593Link 2
Add
BLAST

Sequence similaritiesi

Belongs to the HAPLN family.
Contains 2 Link domains.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG42970.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ86UW8.
KOiK06853.
OMAiKWTKVTD.
PhylomeDBiQ86UW8.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00408. IGc2. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UW8-1 [UniParc]FASTAAdd to Basket

« Hide

MVCARAALGP GALWAAAWGV LLLTAPAGAQ RGRKKVVHVL EGESGSVVVQ    50
TAPGQVVSHR GGTIVLPCRY HYEAAAHGHD GVRLKWTKVV DPLAFTDVFV 100
ALGPQHRAFG SYRGRAELQG DGPGDASLVL RNVTLQDYGR YECEVTNELE 150
DDAGMVKLDL EGVVFPYHPR GGRYKLTFAE AQRACAEQDG ILASAEQLHA 200
AWRDGLDWCN AGWLRDGSVQ YPVNRPREPC GGLGGTGSAG GGGDANGGLR 250
NYGYRHNAEE RYDAFCFTSN LPGRVFFLKP LRPVPFSGAA RACAARGAAV 300
AKVGQLFAAW KLQLLDRCTA GWLADGSARY PIVNPRARCG GRRPGVRSLG 350
FPDATRRLFG VYCYRAPGAP DPAPGGWGWG WAGGGGWAGG ARDPAAWTPL 400
HV 402
Length:402
Mass (Da):42,801
Last modified:June 1, 2003 - v1
Checksum:iB1B6CE2098244124
GO

Sequence cautioni

The sequence BAB67819.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY262756 mRNA. Translation: AAP22048.1.
AB107883 mRNA. Translation: BAC79077.1.
AB067513 mRNA. Translation: BAB67819.1. Different initiation.
CH471106 Genomic DNA. Translation: EAW84804.1.
BC142644 mRNA. Translation: AAI42645.1.
BC142698 mRNA. Translation: AAI42699.1.
CCDSiCCDS12398.1.
RefSeqiNP_075378.1. NM_023002.2.
UniGeneiHs.367829.

Genome annotation databases

EnsembliENST00000291481; ENSP00000291481; ENSG00000187664.
GeneIDi404037.
KEGGihsa:404037.
UCSCiuc002nmb.3. human.

Polymorphism databases

DMDMi47605684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY262756 mRNA. Translation: AAP22048.1 .
AB107883 mRNA. Translation: BAC79077.1 .
AB067513 mRNA. Translation: BAB67819.1 . Different initiation.
CH471106 Genomic DNA. Translation: EAW84804.1 .
BC142644 mRNA. Translation: AAI42645.1 .
BC142698 mRNA. Translation: AAI42699.1 .
CCDSi CCDS12398.1.
RefSeqi NP_075378.1. NM_023002.2.
UniGenei Hs.367829.

3D structure databases

ProteinModelPortali Q86UW8.
SMRi Q86UW8. Positions 55-161, 164-267, 275-366.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q86UW8.

Polymorphism databases

DMDMi 47605684.

Proteomic databases

MaxQBi Q86UW8.
PaxDbi Q86UW8.
PRIDEi Q86UW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000291481 ; ENSP00000291481 ; ENSG00000187664 .
GeneIDi 404037.
KEGGi hsa:404037.
UCSCi uc002nmb.3. human.

Organism-specific databases

CTDi 404037.
GeneCardsi GC19M019366.
HGNCi HGNC:31357. HAPLN4.
HPAi HPA055856.
neXtProti NX_Q86UW8.
PharmGKBi PA134886721.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42970.
HOGENOMi HOG000234353.
HOVERGENi HBG051922.
InParanoidi Q86UW8.
KOi K06853.
OMAi KWTKVTD.
PhylomeDBi Q86UW8.
TreeFami TF332134.

Miscellaneous databases

GenomeRNAii 404037.
NextBioi 107801.
PROi Q86UW8.

Gene expression databases

CleanExi HS_HAPLN4.
Genevestigatori Q86UW8.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProi IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view ]
PRINTSi PR01265. LINKMODULE.
SMARTi SM00408. IGc2. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 2 hits.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links."
    Spicer A.P., Joo A., Bowling R.A. Jr.
    J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets."
    Bekku Y., Su W.-D., Hirakawa S., Faessler R., Ohtsuka A., Kang J.S., Sanders J., Murakami T., Ninomiya Y., Oohashi T.
    Mol. Cell. Neurosci. 24:148-159(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHPLN4_HUMAN
AccessioniPrimary (citable) accession number: Q86UW8
Secondary accession number(s): A5PKW5, Q96PW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi