Calcium-dependent secretion activator 2

Names and origin

Protein names

Recommended name:
    Calcium-dependent secretion activator 2
Alternative name(s):
    Calcium-dependent activator protein for secretion 2
      Short name=CAPS-2

Gene names

Name:	CADPS2
Synonyms:	CAPS2, KIAA1591

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1296 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca²⁺-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles By similarity.
Subunit structure	Homodimer By similarity. Interacts with the dopamine receptor DRD2. Ref.9
Subcellular location	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side Potential. Cell junction › synapse. Note: Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.
Tissue specificity	Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen. Ref.2
Domain	The PH domain is essential for regulated exocytosis and binds phospholipids By similarity.
Post-translational modification	Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR. Ref.10
Sequence similarities	Contains 1 C2 domain. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 PH domain.
Sequence caution	The sequence AAH54339.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. The sequence AK098170 differs from that shown. Reason: Miscellaneous discrepancy. Chimera.

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Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Calcium Lipid-binding Metal-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86UW7-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86UW7-2) The sequence of this isoform differs from the canonical sequence as follows: 618-621: SGKD → Y 860-862: Missing. 963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N 1104-1104: E → EFGSQW
Note: Phosphorylated on Ser-1061 upon DNA damage, probably by ATM or ATR.

Isoform 3 (identifier: Q86UW7-3) The sequence of this isoform differs from the canonical sequence as follows: 618-621: SGKD → Y 860-862: Missing. 963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1296

1296

Calcium-dependent secretion activator 2

PRO_0000053868

Regions

Domain

367 – 447

81

C2

Domain

487 – 590

104

PH

Domain

885 – 1056

172

MHD1

Region

755 – 1074

320

Interaction with DRD2

Amino acid modifications

Modified residue

586

1

Phosphotyrosine By similarity

Natural variations

Alternative sequence

618 – 621

4

SGKD → Y in isoform 2 and isoform 3.

VSP_016815

Alternative sequence

860 – 862

3

Missing in isoform 2 and isoform 3.

VSP_016816

Alternative sequence

963 – 1003

41

KNIAN…LYEST → N in isoform 2 and isoform 3.

VSP_016817

Alternative sequence

1104

1

E → EFGSQW in isoform 2.

VSP_016818

Natural variant

298

1

A → T: dbSNP rs17144625. Ref.2

VAR_024786

Experimental info

Sequence conflict

44 – 47

4

APGR → GRG in AAN38707. Ref.2

Sequence conflict

90

1

F → L in AAP22132. Ref.1

Sequence conflict

360

1

D → G in AAP22132. Ref.1

Sequence conflict

457

1

S → T in AK098170. Ref.6

Sequence conflict

488

1

M → I in AAN38707. Ref.2

Sequence conflict

579

1

I → V in BAB15210. Ref.6

Sequence conflict

1068

1

S → G in BAB15210. Ref.6

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 7BF3456F3D90410C Show »	FASTA	1,296	147,735
10 20 30 40 50 60 MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG GGAARSVSPS 70 80 90 100 110 120 PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN AKQPTDMARR QQKLNKQQLQ 130 140 150 160 170 180 LLKERFQAFL NGETQIVADE AFCNAVRSYY EVFLKSDRVA RMVQSGGCSA NDFREVFKKN 190 200 210 220 230 240 IEKRVRSLPE IDGLSKETVL SSWIAKYDAI YRGEEDLCKQ PNRMALSAVS ELILSKEQLY 250 260 270 280 290 300 EMFQQILGIK KLEHQLLYNA CQLDNADEQA AQIRRELDGR LQLADKMAKE RKFPKFIAKD 310 320 330 340 350 360 MENMYIEELR SSVNLLMANL ESLPVSKGGP EFKLQKLKRS QNSAFLDIGD ENEIQLSKSD 370 380 390 400 410 420 VVLSFTLEIV IMEVQGLKSV APNRIVYCTM EVEGEKLQTD QAEASRPQWG TQGDFTTTHP 430 440 450 460 470 480 RPVVKVKLFT ESTGVLALED KELGRVILYP TSNSSKSAEL HRMVVPKNSQ DSDLKIKLAV 490 500 510 520 530 540 RMDKPAHMKH SGYLYALGQK VWKRWKKRYF VLVQVSQYTF AMCSYREKKS EPQELMQLEG 550 560 570 580 590 600 YTVDYTDPHP GLQGGCMFFN AVKEGDTVIF ASDDEQDRIL WVQAMYRATG QSYKPVPAIQ 610 620 630 640 650 660 TQKLNPKGGT LHADAQLSGK DADRFQKHGM DEFISANPCK LDHAFLFRIL QRQTLDHRLN 670 680 690 700 710 720 DSYSCLGWFS PGQVFVLDEY CARYGVRGCH RHLCYLAELM EHSENGAVID PTLLHYSFAF 730 740 750 760 770 780 CASHVHGNRP DGIGTVSVEE KERFEEIKER LSSLLENQIS HFRYCFPFGR PEGALKATLS 790 800 810 820 830 840 LLERVLMKDI ATPIPAEEVK KVVRKCLEKA ALINYTRLTE YAKIEETMNQ ASPARKLEEI 850 860 870 880 890 900 LHLAELCIEV LQQNEEHHAE GREAFAWWPD LLAEHAEKFW ALFTVDMDTA LEAQPQDSWD 910 920 930 940 950 960 SFPLFQLLNN FLRNDTLLCN GKFHKHLQEI FVPLVVRYVD LMESSIAQSI HRGFEQETWQ 970 980 990 1000 1010 1020 PVKNIANSLP NVALPKVPSL PLNLPQIPNI STASWMPSLY ESTNGSATSE DLFWKLDALQ 1030 1040 1050 1060 1070 1080 MFVFDLHWPE QEFAHHLEQR LKLMASDMLE ACVKRTRTAF ELKLQKASKT TDLRIPASVC 1090 1100 1110 1120 1130 1140 TMFNVLVDAK KQSTKLCALD GGQEQQYHSK IDDLIDNSVK EIISLLVSKF VSVLEGVLSK 1150 1160 1170 1180 1190 1200 LSRYDEGTFF SSILSFTVKA AAKYVDVPKP GMDLADTYIM FVRQNQDILR EKVNEEMYIE 1210 1220 1230 1240 1250 1260 KLFDQWYSSS MKVICVWLTD RLDLQLHIYQ LKTLIKIVKK TYRDFRLQGV LEGTLNSKTY 1270 1280 1290 DTVHRRLTVE EATASVSEGG GLQGITMKDS DEEEEG « Hide
Isoform 2. Checksum: D13DA3579388CC04 Show »	FASTA	1,255	143,489
10 20 30 40 50 60 MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG GGAARSVSPS 70 80 90 100 110 120 PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN AKQPTDMARR QQKLNKQQLQ 130 140 150 160 170 180 LLKERFQAFL NGETQIVADE AFCNAVRSYY EVFLKSDRVA RMVQSGGCSA NDFREVFKKN 190 200 210 220 230 240 IEKRVRSLPE IDGLSKETVL SSWIAKYDAI YRGEEDLCKQ PNRMALSAVS ELILSKEQLY 250 260 270 280 290 300 EMFQQILGIK KLEHQLLYNA CQLDNADEQA AQIRRELDGR LQLADKMAKE RKFPKFIAKD 310 320 330 340 350 360 MENMYIEELR SSVNLLMANL ESLPVSKGGP EFKLQKLKRS QNSAFLDIGD ENEIQLSKSD 370 380 390 400 410 420 VVLSFTLEIV IMEVQGLKSV APNRIVYCTM EVEGEKLQTD QAEASRPQWG TQGDFTTTHP 430 440 450 460 470 480 RPVVKVKLFT ESTGVLALED KELGRVILYP TSNSSKSAEL HRMVVPKNSQ DSDLKIKLAV 490 500 510 520 530 540 RMDKPAHMKH SGYLYALGQK VWKRWKKRYF VLVQVSQYTF AMCSYREKKS EPQELMQLEG 550 560 570 580 590 600 YTVDYTDPHP GLQGGCMFFN AVKEGDTVIF ASDDEQDRIL WVQAMYRATG QSYKPVPAIQ 610 620 630 640 650 660 TQKLNPKGGT LHADAQLYAD RFQKHGMDEF ISANPCKLDH AFLFRILQRQ TLDHRLNDSY 670 680 690 700 710 720 SCLGWFSPGQ VFVLDEYCAR YGVRGCHRHL CYLAELMEHS ENGAVIDPTL LHYSFAFCAS 730 740 750 760 770 780 HVHGNRPDGI GTVSVEEKER FEEIKERLSS LLENQISHFR YCFPFGRPEG ALKATLSLLE 790 800 810 820 830 840 RVLMKDIATP IPAEEVKKVV RKCLEKAALI NYTRLTEYAK IEETMNQASP ARKLEEILHL 850 860 870 880 890 900 AELCIEVLQQ NEEHHAEAFA WWPDLLAEHA EKFWALFTVD MDTALEAQPQ DSWDSFPLFQ 910 920 930 940 950 960 LLNNFLRNDT LLCNGKFHKH LQEIFVPLVV RYVDLMESSI AQSIHRGFEQ ETWQPVNNGS 970 980 990 1000 1010 1020 ATSEDLFWKL DALQMFVFDL HWPEQEFAHH LEQRLKLMAS DMLEACVKRT RTAFELKLQK 1030 1040 1050 1060 1070 1080 ASKTTDLRIP ASVCTMFNVL VDAKKQSTKL CALDGGQEFG SQWQQYHSKI DDLIDNSVKE 1090 1100 1110 1120 1130 1140 IISLLVSKFV SVLEGVLSKL SRYDEGTFFS SILSFTVKAA AKYVDVPKPG MDLADTYIMF 1150 1160 1170 1180 1190 1200 VRQNQDILRE KVNEEMYIEK LFDQWYSSSM KVICVWLTDR LDLQLHIYQL KTLIKIVKKT 1210 1220 1230 1240 1250 YRDFRLQGVL EGTLNSKTYD TVHRRLTVEE ATASVSEGGG LQGITMKDSD EEEEG « Hide
Isoform 3. Checksum: C13FA0A5AC04DD7F Show »	FASTA	1,250	142,883
10 20 30 40 50 60 MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG GGAARSVSPS 70 80 90 100 110 120 PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN AKQPTDMARR QQKLNKQQLQ 130 140 150 160 170 180 LLKERFQAFL NGETQIVADE AFCNAVRSYY EVFLKSDRVA RMVQSGGCSA NDFREVFKKN 190 200 210 220 230 240 IEKRVRSLPE IDGLSKETVL SSWIAKYDAI YRGEEDLCKQ PNRMALSAVS ELILSKEQLY 250 260 270 280 290 300 EMFQQILGIK KLEHQLLYNA CQLDNADEQA AQIRRELDGR LQLADKMAKE RKFPKFIAKD 310 320 330 340 350 360 MENMYIEELR SSVNLLMANL ESLPVSKGGP EFKLQKLKRS QNSAFLDIGD ENEIQLSKSD 370 380 390 400 410 420 VVLSFTLEIV IMEVQGLKSV APNRIVYCTM EVEGEKLQTD QAEASRPQWG TQGDFTTTHP 430 440 450 460 470 480 RPVVKVKLFT ESTGVLALED KELGRVILYP TSNSSKSAEL HRMVVPKNSQ DSDLKIKLAV 490 500 510 520 530 540 RMDKPAHMKH SGYLYALGQK VWKRWKKRYF VLVQVSQYTF AMCSYREKKS EPQELMQLEG 550 560 570 580 590 600 YTVDYTDPHP GLQGGCMFFN AVKEGDTVIF ASDDEQDRIL WVQAMYRATG QSYKPVPAIQ 610 620 630 640 650 660 TQKLNPKGGT LHADAQLYAD RFQKHGMDEF ISANPCKLDH AFLFRILQRQ TLDHRLNDSY 670 680 690 700 710 720 SCLGWFSPGQ VFVLDEYCAR YGVRGCHRHL CYLAELMEHS ENGAVIDPTL LHYSFAFCAS 730 740 750 760 770 780 HVHGNRPDGI GTVSVEEKER FEEIKERLSS LLENQISHFR YCFPFGRPEG ALKATLSLLE 790 800 810 820 830 840 RVLMKDIATP IPAEEVKKVV RKCLEKAALI NYTRLTEYAK IEETMNQASP ARKLEEILHL 850 860 870 880 890 900 AELCIEVLQQ NEEHHAEAFA WWPDLLAEHA EKFWALFTVD MDTALEAQPQ DSWDSFPLFQ 910 920 930 940 950 960 LLNNFLRNDT LLCNGKFHKH LQEIFVPLVV RYVDLMESSI AQSIHRGFEQ ETWQPVNNGS 970 980 990 1000 1010 1020 ATSEDLFWKL DALQMFVFDL HWPEQEFAHH LEQRLKLMAS DMLEACVKRT RTAFELKLQK 1030 1040 1050 1060 1070 1080 ASKTTDLRIP ASVCTMFNVL VDAKKQSTKL CALDGGQEQQ YHSKIDDLID NSVKEIISLL 1090 1100 1110 1120 1130 1140 VSKFVSVLEG VLSKLSRYDE GTFFSSILSF TVKAAAKYVD VPKPGMDLAD TYIMFVRQNQ 1150 1160 1170 1180 1190 1200 DILREKVNEE MYIEKLFDQW YSSSMKVICV WLTDRLDLQL HIYQLKTLIK IVKKTYRDFR 1210 1220 1230 1240 1250 LQGVLEGTLN SKTYDTVHRR LTVEEATASV SEGGGLQGIT MKDSDEEEEG « Hide

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References

[1]	"A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function." Speidel D., Varoqueaux F., Enk C., Nojiri M., Grishanin R.N., Martin T.F.J., Hofmann K., Brose N., Reim K. J. Biol. Chem. 278:52802-52809(2003) [PubMed: 14530279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family." Cisternas F.A., Vincent J.B., Scherer S.W., Ray P.N. Genomics 81:279-291(2003) [PubMed: 12659812] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANT THR-298.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-180. Tissue: Brain, Skin and Testis.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-506 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1296 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-1296 (ISOFORM 3). Tissue: Hepatoma and Trachea.
[7]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed: 10997877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-1296 (ISOFORM 2).
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 262-1296 (ISOFORM 2). Tissue: Stomach.
[9]	"Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)." Binda A.V., Kabbani N., Levenson R. Biochem. Pharmacol. 69:1451-1461(2005) [PubMed: 15857609] [Abstract] Cited for: INTERACTION WITH DRD2.
[10]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1061 (ISOFORM 2), MASS SPECTROMETRY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AY264289 mRNA. Translation: AAP22132.1. AF401638 mRNA. Translation: AAN38707.1. AC004594 Genomic DNA. No translation available. AC004838 Genomic DNA. No translation available. AC004986 Genomic DNA. No translation available. AC006009 Genomic DNA. No translation available. AC006463 Genomic DNA. No translation available. AC015983 Genomic DNA. No translation available. AC091438 Genomic DNA. No translation available. CH236947 Genomic DNA. Translation: EAL24339.1. BC054339 mRNA. Translation: AAH54339.1. Sequence problems. BC136601 mRNA. Translation: AAI36602.1. BC144278 mRNA. Translation: AAI44279.1. AK000768 mRNA. Translation: BAA91372.1. Different initiation. AK025672 mRNA. Translation: BAB15210.1. Different initiation. AK098170 mRNA. No translation available. AB046811 mRNA. Translation: BAB13417.1. AL833058 mRNA. Translation: CAH56288.1.
IPI	IPI00550275. IPI00873837. IPI00945569.
RefSeq	NP_001009571.2. NP_060424.9.
UniGene	Hs.708214
3D structure databases
SMR	Q86UW7. Positions 488-601.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86UW7. 1 interaction.
STRING	Q86UW7.
PTM databases
PhosphoSite	Q86UW7.
Genome annotation databases
Ensembl	ENST00000449022; ENSP00000398481; ENSG00000081803; Homo sapiens. [Genome view]
GeneID	93664.
KEGG	hsa:93664.
UCSC	uc003vkg.2. human. uc010lkq.1. human.
Organism-specific databases
CTD	93664.
GeneCards	GC07M121746.
H-InvDB	HIX0007033.
HGNC	HGNC:16018. CADPS2.
MIM	609978. gene.
PharmGKB	PA26025.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16624.
HOVERGEN	Q86UW7.
InParanoid	Q86UW7.
Gene expression databases
ArrayExpress	Q86UW7.
Bgee	Q86UW7.
CleanEx	HS_CAPS2.
Genevestigator	Q86UW7.
GermOnline	ENSG00000081803. Homo sapiens.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR010439. DUF1041. IPR014770. Munc13_1. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF06292. DUF1041. 1 hit. PF00169. PH. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50004. C2. False negative. PS51258. MHD1. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	78208.
SOURCE	Search...

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Entry information

Entry name

CAPS2_HUMAN

Accession

Primary (citable) accession number: Q86UW7
Secondary accession number(s): A4D0X3

Q9NWK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	February 9, 2010
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents