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Q86UW7

- CAPS2_HUMAN

UniProt

Q86UW7 - CAPS2_HUMAN

Protein

Calcium-dependent secretion activator 2

Gene

CADPS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca2+-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles By similarity.By similarity

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of exocytosis Source: Ensembl
    2. protein transport Source: UniProtKB-KW
    3. synaptic vesicle priming Source: Ensembl

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Keywords - Ligandi

    Calcium, Lipid-binding, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-dependent secretion activator 2
    Alternative name(s):
    Calcium-dependent activator protein for secretion 2
    Short name:
    CAPS-2
    Gene namesi
    Name:CADPS2
    Synonyms:CAPS2, KIAA1591
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:16018. CADPS2.

    Subcellular locationi

    Cytoplasmic vesicle membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated. Cell junctionsynapse
    Note: Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. postsynaptic membrane Source: Ensembl
    4. presynaptic membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26025.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12961296Calcium-dependent secretion activator 2PRO_0000053868Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei56 – 561Phosphoserine1 Publication
    Modified residuei58 – 581Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86UW7.
    PaxDbiQ86UW7.
    PRIDEiQ86UW7.

    PTM databases

    PhosphoSiteiQ86UW7.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.1 Publication

    Gene expression databases

    ArrayExpressiQ86UW7.
    BgeeiQ86UW7.
    CleanExiHS_CAPS2.
    GenevestigatoriQ86UW7.

    Interactioni

    Subunit structurei

    Homodimer By similarity. Interacts with the dopamine receptor DRD2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi125051. 11 interactions.
    IntActiQ86UW7. 13 interactions.
    MINTiMINT-6939745.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UW7.
    SMRiQ86UW7. Positions 488-601.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini367 – 44781C2Add
    BLAST
    Domaini487 – 590104PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini885 – 1056172MHD1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni755 – 1074320Interaction with DRD2Add
    BLAST

    Domaini

    The PH domain is essential for regulated exocytosis and binds phospholipids.By similarity

    Sequence similaritiesi

    Contains 1 C2 domain.Curated
    Contains 1 MHD1 (MUNC13 homology domain 1) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG292723.
    HOVERGENiHBG080678.
    InParanoidiQ86UW7.
    OMAiHMKHSGY.
    OrthoDBiEOG7K0ZD0.
    PhylomeDBiQ86UW7.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR010439. Ca-dep_secretion_activator.
    IPR014770. Munc13_1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF06292. DUF1041. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    PROSITEiPS51258. MHD1. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86UW7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG     50
    GGAARSVSPS PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN 100
    AKQPTDMARR QQKLNKQQLQ LLKERFQAFL NGETQIVADE AFCNAVRSYY 150
    EVFLKSDRVA RMVQSGGCSA NDFREVFKKN IEKRVRSLPE IDGLSKETVL 200
    SSWIAKYDAI YRGEEDLCKQ PNRMALSAVS ELILSKEQLY EMFQQILGIK 250
    KLEHQLLYNA CQLDNADEQA AQIRRELDGR LQLADKMAKE RKFPKFIAKD 300
    MENMYIEELR SSVNLLMANL ESLPVSKGGP EFKLQKLKRS QNSAFLDIGD 350
    ENEIQLSKSD VVLSFTLEIV IMEVQGLKSV APNRIVYCTM EVEGEKLQTD 400
    QAEASRPQWG TQGDFTTTHP RPVVKVKLFT ESTGVLALED KELGRVILYP 450
    TSNSSKSAEL HRMVVPKNSQ DSDLKIKLAV RMDKPAHMKH SGYLYALGQK 500
    VWKRWKKRYF VLVQVSQYTF AMCSYREKKS EPQELMQLEG YTVDYTDPHP 550
    GLQGGCMFFN AVKEGDTVIF ASDDEQDRIL WVQAMYRATG QSYKPVPAIQ 600
    TQKLNPKGGT LHADAQLSGK DADRFQKHGM DEFISANPCK LDHAFLFRIL 650
    QRQTLDHRLN DSYSCLGWFS PGQVFVLDEY CARYGVRGCH RHLCYLAELM 700
    EHSENGAVID PTLLHYSFAF CASHVHGNRP DGIGTVSVEE KERFEEIKER 750
    LSSLLENQIS HFRYCFPFGR PEGALKATLS LLERVLMKDI ATPIPAEEVK 800
    KVVRKCLEKA ALINYTRLTE YAKIEETMNQ ASPARKLEEI LHLAELCIEV 850
    LQQNEEHHAE GREAFAWWPD LLAEHAEKFW ALFTVDMDTA LEAQPQDSWD 900
    SFPLFQLLNN FLRNDTLLCN GKFHKHLQEI FVPLVVRYVD LMESSIAQSI 950
    HRGFEQETWQ PVKNIANSLP NVALPKVPSL PLNLPQIPNI STASWMPSLY 1000
    ESTNGSATSE DLFWKLDALQ MFVFDLHWPE QEFAHHLEQR LKLMASDMLE 1050
    ACVKRTRTAF ELKLQKASKT TDLRIPASVC TMFNVLVDAK KQSTKLCALD 1100
    GGQEQQYHSK IDDLIDNSVK EIISLLVSKF VSVLEGVLSK LSRYDEGTFF 1150
    SSILSFTVKA AAKYVDVPKP GMDLADTYIM FVRQNQDILR EKVNEEMYIE 1200
    KLFDQWYSSS MKVICVWLTD RLDLQLHIYQ LKTLIKIVKK TYRDFRLQGV 1250
    LEGTLNSKTY DTVHRRLTVE EATASVSEGG GLQGITMKDS DEEEEG 1296
    Length:1,296
    Mass (Da):147,735
    Last modified:January 10, 2006 - v2
    Checksum:i7BF3456F3D90410C
    GO
    Isoform 2 (identifier: Q86UW7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         618-621: SGKD → Y
         860-862: Missing.
         963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N
         1104-1104: E → EFGSQW

    Show »
    Length:1,255
    Mass (Da):143,489
    Checksum:iD13DA3579388CC04
    GO
    Isoform 3 (identifier: Q86UW7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         618-621: SGKD → Y
         860-862: Missing.
         963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N

    Note: No experimental confirmation available.

    Show »
    Length:1,250
    Mass (Da):142,883
    Checksum:iC13FA0A5AC04DD7F
    GO

    Sequence cautioni

    The sequence AAH54339.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AK098170 differs from that shown. Reason: Chimera.
    The sequence BAA91372.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB15210.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 474APGR → GRG in AAN38707. (PubMed:12659812)Curated
    Sequence conflicti90 – 901F → L in AAP22132. (PubMed:14530279)Curated
    Sequence conflicti360 – 3601D → G in AAP22132. (PubMed:14530279)Curated
    Sequence conflicti457 – 4571S → T in AK098170. (PubMed:14702039)Curated
    Sequence conflicti488 – 4881M → I in AAN38707. (PubMed:12659812)Curated
    Sequence conflicti579 – 5791I → V in BAB15210. (PubMed:14702039)Curated
    Sequence conflicti1068 – 10681S → G in BAB15210. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti298 – 2981A → T.1 Publication
    Corresponds to variant rs17144625 [ dbSNP | Ensembl ].
    VAR_024786

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei618 – 6214SGKD → Y in isoform 2 and isoform 3. 5 PublicationsVSP_016815
    Alternative sequencei860 – 8623Missing in isoform 2 and isoform 3. 5 PublicationsVSP_016816
    Alternative sequencei963 – 100341KNIAN…LYEST → N in isoform 2 and isoform 3. 5 PublicationsVSP_016817Add
    BLAST
    Alternative sequencei1104 – 11041E → EFGSQW in isoform 2. 5 PublicationsVSP_016818

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY264289 mRNA. Translation: AAP22132.1.
    AF401638 mRNA. Translation: AAN38707.1.
    AC004594 Genomic DNA. No translation available.
    AC004838 Genomic DNA. No translation available.
    AC004986 Genomic DNA. No translation available.
    AC006009 Genomic DNA. No translation available.
    AC006463 Genomic DNA. No translation available.
    AC015983 Genomic DNA. No translation available.
    AC091438 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24339.1.
    BC054339 mRNA. Translation: AAH54339.1. Sequence problems.
    BC136601 mRNA. Translation: AAI36602.1.
    BC144278 mRNA. Translation: AAI44279.1.
    AK000768 mRNA. Translation: BAA91372.1. Different initiation.
    AK025672 mRNA. Translation: BAB15210.1. Different initiation.
    AK098170 mRNA. No translation available.
    AB046811 mRNA. Translation: BAB13417.1.
    AL833058 mRNA. Translation: CAH56288.1.
    CCDSiCCDS47691.1. [Q86UW7-2]
    CCDS55158.1. [Q86UW7-1]
    RefSeqiNP_001009571.2. NM_001009571.3. [Q86UW7-2]
    NP_001161412.1. NM_001167940.1.
    NP_060424.9. NM_017954.10. [Q86UW7-1]
    UniGeneiHs.649459.

    Genome annotation databases

    EnsembliENST00000412584; ENSP00000400401; ENSG00000081803. [Q86UW7-2]
    ENST00000449022; ENSP00000398481; ENSG00000081803. [Q86UW7-1]
    GeneIDi93664.
    KEGGihsa:93664.
    UCSCiuc003vkg.4. human. [Q86UW7-3]
    uc010lkq.3. human. [Q86UW7-2]
    uc022akq.1. human. [Q86UW7-1]

    Polymorphism databases

    DMDMi85540964.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY264289 mRNA. Translation: AAP22132.1 .
    AF401638 mRNA. Translation: AAN38707.1 .
    AC004594 Genomic DNA. No translation available.
    AC004838 Genomic DNA. No translation available.
    AC004986 Genomic DNA. No translation available.
    AC006009 Genomic DNA. No translation available.
    AC006463 Genomic DNA. No translation available.
    AC015983 Genomic DNA. No translation available.
    AC091438 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24339.1 .
    BC054339 mRNA. Translation: AAH54339.1 . Sequence problems.
    BC136601 mRNA. Translation: AAI36602.1 .
    BC144278 mRNA. Translation: AAI44279.1 .
    AK000768 mRNA. Translation: BAA91372.1 . Different initiation.
    AK025672 mRNA. Translation: BAB15210.1 . Different initiation.
    AK098170 mRNA. No translation available.
    AB046811 mRNA. Translation: BAB13417.1 .
    AL833058 mRNA. Translation: CAH56288.1 .
    CCDSi CCDS47691.1. [Q86UW7-2 ]
    CCDS55158.1. [Q86UW7-1 ]
    RefSeqi NP_001009571.2. NM_001009571.3. [Q86UW7-2 ]
    NP_001161412.1. NM_001167940.1.
    NP_060424.9. NM_017954.10. [Q86UW7-1 ]
    UniGenei Hs.649459.

    3D structure databases

    ProteinModelPortali Q86UW7.
    SMRi Q86UW7. Positions 488-601.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125051. 11 interactions.
    IntActi Q86UW7. 13 interactions.
    MINTi MINT-6939745.

    PTM databases

    PhosphoSitei Q86UW7.

    Polymorphism databases

    DMDMi 85540964.

    Proteomic databases

    MaxQBi Q86UW7.
    PaxDbi Q86UW7.
    PRIDEi Q86UW7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412584 ; ENSP00000400401 ; ENSG00000081803 . [Q86UW7-2 ]
    ENST00000449022 ; ENSP00000398481 ; ENSG00000081803 . [Q86UW7-1 ]
    GeneIDi 93664.
    KEGGi hsa:93664.
    UCSCi uc003vkg.4. human. [Q86UW7-3 ]
    uc010lkq.3. human. [Q86UW7-2 ]
    uc022akq.1. human. [Q86UW7-1 ]

    Organism-specific databases

    CTDi 93664.
    GeneCardsi GC07M121958.
    HGNCi HGNC:16018. CADPS2.
    MIMi 609978. gene.
    neXtProti NX_Q86UW7.
    PharmGKBi PA26025.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292723.
    HOVERGENi HBG080678.
    InParanoidi Q86UW7.
    OMAi HMKHSGY.
    OrthoDBi EOG7K0ZD0.
    PhylomeDBi Q86UW7.

    Miscellaneous databases

    ChiTaRSi CADPS2. human.
    GeneWikii CADPS2.
    GenomeRNAii 93664.
    NextBioi 78208.
    PROi Q86UW7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UW7.
    Bgeei Q86UW7.
    CleanExi HS_CAPS2.
    Genevestigatori Q86UW7.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR010439. Ca-dep_secretion_activator.
    IPR014770. Munc13_1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF06292. DUF1041. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    PROSITEi PS51258. MHD1. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function."
      Speidel D., Varoqueaux F., Enk C., Nojiri M., Grishanin R.N., Martin T.F.J., Hofmann K., Brose N., Reim K.
      J. Biol. Chem. 278:52802-52809(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family."
      Cisternas F.A., Vincent J.B., Scherer S.W., Ray P.N.
      Genomics 81:279-291(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANT THR-298.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-180.
      Tissue: Brain, Skin and Testis.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-506 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1296 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-1296 (ISOFORM 3).
      Tissue: Hepatoma and Trachea.
    7. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-1296 (ISOFORM 2).
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 262-1296 (ISOFORM 2).
      Tissue: Stomach.
    9. "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)."
      Binda A.V., Kabbani N., Levenson R.
      Biochem. Pharmacol. 69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DRD2.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56 AND SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCAPS2_HUMAN
    AccessioniPrimary (citable) accession number: Q86UW7
    Secondary accession number(s): A4D0X3
    , B7ZM56, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3