Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q86UW7

- CAPS2_HUMAN

UniProt

Q86UW7 - CAPS2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Calcium-dependent secretion activator 2

Gene

CADPS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca2+-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).By similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to starvation Source: Ensembl
  2. positive regulation of exocytosis Source: Ensembl
  3. protein transport Source: UniProtKB-KW
  4. synaptic vesicle priming Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Keywords - Ligandi

Calcium, Lipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-dependent secretion activator 2
Alternative name(s):
Calcium-dependent activator protein for secretion 2
Short name:
CAPS-2
Gene namesi
Name:CADPS2
Synonyms:CAPS2, KIAA1591
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:16018. CADPS2.

Subcellular locationi

Cytoplasmic vesicle membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated. Cell junctionsynapse
Note: Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasmic membrane-bounded vesicle Source: Ensembl
  3. postsynaptic membrane Source: Ensembl
  4. presynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12961296Calcium-dependent secretion activator 2PRO_0000053868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561Phosphoserine1 Publication
Modified residuei58 – 581Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86UW7.
PaxDbiQ86UW7.
PRIDEiQ86UW7.

PTM databases

PhosphoSiteiQ86UW7.

Expressioni

Tissue specificityi

Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.1 Publication

Gene expression databases

BgeeiQ86UW7.
CleanExiHS_CAPS2.
ExpressionAtlasiQ86UW7. baseline and differential.
GenevestigatoriQ86UW7.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with the dopamine receptor DRD2.By similarity1 Publication

Protein-protein interaction databases

BioGridi125051. 12 interactions.
IntActiQ86UW7. 13 interactions.
MINTiMINT-6939745.

Structurei

3D structure databases

ProteinModelPortaliQ86UW7.
SMRiQ86UW7. Positions 488-601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini367 – 44781C2Add
BLAST
Domaini487 – 590104PHPROSITE-ProRule annotationAdd
BLAST
Domaini885 – 1056172MHD1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni755 – 1074320Interaction with DRD2Add
BLAST

Domaini

The PH domain is essential for regulated exocytosis and binds phospholipids.By similarity

Sequence similaritiesi

Contains 1 C2 domain.Curated
Contains 1 MHD1 (MUNC13 homology domain 1) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG292723.
GeneTreeiENSGT00590000083094.
HOVERGENiHBG080678.
InParanoidiQ86UW7.
OMAiHMKHSGY.
OrthoDBiEOG7K0ZD0.
PhylomeDBiQ86UW7.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000008. C2_dom.
IPR010439. Ca-dep_secretion_activator.
IPR014770. Munc13_1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF06292. DUF1041. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS51258. MHD1. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86UW7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG
60 70 80 90 100
GGAARSVSPS PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN
110 120 130 140 150
AKQPTDMARR QQKLNKQQLQ LLKERFQAFL NGETQIVADE AFCNAVRSYY
160 170 180 190 200
EVFLKSDRVA RMVQSGGCSA NDFREVFKKN IEKRVRSLPE IDGLSKETVL
210 220 230 240 250
SSWIAKYDAI YRGEEDLCKQ PNRMALSAVS ELILSKEQLY EMFQQILGIK
260 270 280 290 300
KLEHQLLYNA CQLDNADEQA AQIRRELDGR LQLADKMAKE RKFPKFIAKD
310 320 330 340 350
MENMYIEELR SSVNLLMANL ESLPVSKGGP EFKLQKLKRS QNSAFLDIGD
360 370 380 390 400
ENEIQLSKSD VVLSFTLEIV IMEVQGLKSV APNRIVYCTM EVEGEKLQTD
410 420 430 440 450
QAEASRPQWG TQGDFTTTHP RPVVKVKLFT ESTGVLALED KELGRVILYP
460 470 480 490 500
TSNSSKSAEL HRMVVPKNSQ DSDLKIKLAV RMDKPAHMKH SGYLYALGQK
510 520 530 540 550
VWKRWKKRYF VLVQVSQYTF AMCSYREKKS EPQELMQLEG YTVDYTDPHP
560 570 580 590 600
GLQGGCMFFN AVKEGDTVIF ASDDEQDRIL WVQAMYRATG QSYKPVPAIQ
610 620 630 640 650
TQKLNPKGGT LHADAQLSGK DADRFQKHGM DEFISANPCK LDHAFLFRIL
660 670 680 690 700
QRQTLDHRLN DSYSCLGWFS PGQVFVLDEY CARYGVRGCH RHLCYLAELM
710 720 730 740 750
EHSENGAVID PTLLHYSFAF CASHVHGNRP DGIGTVSVEE KERFEEIKER
760 770 780 790 800
LSSLLENQIS HFRYCFPFGR PEGALKATLS LLERVLMKDI ATPIPAEEVK
810 820 830 840 850
KVVRKCLEKA ALINYTRLTE YAKIEETMNQ ASPARKLEEI LHLAELCIEV
860 870 880 890 900
LQQNEEHHAE GREAFAWWPD LLAEHAEKFW ALFTVDMDTA LEAQPQDSWD
910 920 930 940 950
SFPLFQLLNN FLRNDTLLCN GKFHKHLQEI FVPLVVRYVD LMESSIAQSI
960 970 980 990 1000
HRGFEQETWQ PVKNIANSLP NVALPKVPSL PLNLPQIPNI STASWMPSLY
1010 1020 1030 1040 1050
ESTNGSATSE DLFWKLDALQ MFVFDLHWPE QEFAHHLEQR LKLMASDMLE
1060 1070 1080 1090 1100
ACVKRTRTAF ELKLQKASKT TDLRIPASVC TMFNVLVDAK KQSTKLCALD
1110 1120 1130 1140 1150
GGQEQQYHSK IDDLIDNSVK EIISLLVSKF VSVLEGVLSK LSRYDEGTFF
1160 1170 1180 1190 1200
SSILSFTVKA AAKYVDVPKP GMDLADTYIM FVRQNQDILR EKVNEEMYIE
1210 1220 1230 1240 1250
KLFDQWYSSS MKVICVWLTD RLDLQLHIYQ LKTLIKIVKK TYRDFRLQGV
1260 1270 1280 1290
LEGTLNSKTY DTVHRRLTVE EATASVSEGG GLQGITMKDS DEEEEG
Length:1,296
Mass (Da):147,735
Last modified:January 10, 2006 - v2
Checksum:i7BF3456F3D90410C
GO
Isoform 2 (identifier: Q86UW7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-621: SGKD → Y
     860-862: Missing.
     963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N
     1104-1104: E → EFGSQW

Show »
Length:1,255
Mass (Da):143,489
Checksum:iD13DA3579388CC04
GO
Isoform 3 (identifier: Q86UW7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-621: SGKD → Y
     860-862: Missing.
     963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N

Note: No experimental confirmation available.

Show »
Length:1,250
Mass (Da):142,883
Checksum:iC13FA0A5AC04DD7F
GO

Sequence cautioni

The sequence AAH54339.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AK098170 differs from that shown. Reason: Chimera.
The sequence BAA91372.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB15210.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 474APGR → GRG in AAN38707. (PubMed:12659812)Curated
Sequence conflicti90 – 901F → L in AAP22132. (PubMed:14530279)Curated
Sequence conflicti360 – 3601D → G in AAP22132. (PubMed:14530279)Curated
Sequence conflicti457 – 4571S → T in AK098170. (PubMed:14702039)Curated
Sequence conflicti488 – 4881M → I in AAN38707. (PubMed:12659812)Curated
Sequence conflicti579 – 5791I → V in BAB15210. (PubMed:14702039)Curated
Sequence conflicti1068 – 10681S → G in BAB15210. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti298 – 2981A → T.1 Publication
Corresponds to variant rs17144625 [ dbSNP | Ensembl ].
VAR_024786

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei618 – 6214SGKD → Y in isoform 2 and isoform 3. 5 PublicationsVSP_016815
Alternative sequencei860 – 8623Missing in isoform 2 and isoform 3. 5 PublicationsVSP_016816
Alternative sequencei963 – 100341KNIAN…LYEST → N in isoform 2 and isoform 3. 5 PublicationsVSP_016817Add
BLAST
Alternative sequencei1104 – 11041E → EFGSQW in isoform 2. 5 PublicationsVSP_016818

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY264289 mRNA. Translation: AAP22132.1.
AF401638 mRNA. Translation: AAN38707.1.
AC004594 Genomic DNA. No translation available.
AC004838 Genomic DNA. No translation available.
AC004986 Genomic DNA. No translation available.
AC006009 Genomic DNA. No translation available.
AC006463 Genomic DNA. No translation available.
AC015983 Genomic DNA. No translation available.
AC091438 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24339.1.
BC054339 mRNA. Translation: AAH54339.1. Sequence problems.
BC136601 mRNA. Translation: AAI36602.1.
BC144278 mRNA. Translation: AAI44279.1.
AK000768 mRNA. Translation: BAA91372.1. Different initiation.
AK025672 mRNA. Translation: BAB15210.1. Different initiation.
AK098170 mRNA. No translation available.
AB046811 mRNA. Translation: BAB13417.1.
AL833058 mRNA. Translation: CAH56288.1.
CCDSiCCDS47691.1. [Q86UW7-2]
CCDS55158.1. [Q86UW7-1]
RefSeqiNP_001009571.2. NM_001009571.3. [Q86UW7-2]
NP_001161412.1. NM_001167940.1.
NP_060424.9. NM_017954.10. [Q86UW7-1]
UniGeneiHs.649459.

Genome annotation databases

EnsembliENST00000412584; ENSP00000400401; ENSG00000081803. [Q86UW7-2]
ENST00000449022; ENSP00000398481; ENSG00000081803. [Q86UW7-1]
GeneIDi93664.
KEGGihsa:93664.
UCSCiuc003vkg.4. human. [Q86UW7-3]
uc010lkq.3. human. [Q86UW7-2]
uc022akq.1. human. [Q86UW7-1]

Polymorphism databases

DMDMi85540964.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY264289 mRNA. Translation: AAP22132.1 .
AF401638 mRNA. Translation: AAN38707.1 .
AC004594 Genomic DNA. No translation available.
AC004838 Genomic DNA. No translation available.
AC004986 Genomic DNA. No translation available.
AC006009 Genomic DNA. No translation available.
AC006463 Genomic DNA. No translation available.
AC015983 Genomic DNA. No translation available.
AC091438 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24339.1 .
BC054339 mRNA. Translation: AAH54339.1 . Sequence problems.
BC136601 mRNA. Translation: AAI36602.1 .
BC144278 mRNA. Translation: AAI44279.1 .
AK000768 mRNA. Translation: BAA91372.1 . Different initiation.
AK025672 mRNA. Translation: BAB15210.1 . Different initiation.
AK098170 mRNA. No translation available.
AB046811 mRNA. Translation: BAB13417.1 .
AL833058 mRNA. Translation: CAH56288.1 .
CCDSi CCDS47691.1. [Q86UW7-2 ]
CCDS55158.1. [Q86UW7-1 ]
RefSeqi NP_001009571.2. NM_001009571.3. [Q86UW7-2 ]
NP_001161412.1. NM_001167940.1.
NP_060424.9. NM_017954.10. [Q86UW7-1 ]
UniGenei Hs.649459.

3D structure databases

ProteinModelPortali Q86UW7.
SMRi Q86UW7. Positions 488-601.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125051. 12 interactions.
IntActi Q86UW7. 13 interactions.
MINTi MINT-6939745.

PTM databases

PhosphoSitei Q86UW7.

Polymorphism databases

DMDMi 85540964.

Proteomic databases

MaxQBi Q86UW7.
PaxDbi Q86UW7.
PRIDEi Q86UW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000412584 ; ENSP00000400401 ; ENSG00000081803 . [Q86UW7-2 ]
ENST00000449022 ; ENSP00000398481 ; ENSG00000081803 . [Q86UW7-1 ]
GeneIDi 93664.
KEGGi hsa:93664.
UCSCi uc003vkg.4. human. [Q86UW7-3 ]
uc010lkq.3. human. [Q86UW7-2 ]
uc022akq.1. human. [Q86UW7-1 ]

Organism-specific databases

CTDi 93664.
GeneCardsi GC07M121958.
HGNCi HGNC:16018. CADPS2.
MIMi 609978. gene.
neXtProti NX_Q86UW7.
PharmGKBi PA26025.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292723.
GeneTreei ENSGT00590000083094.
HOVERGENi HBG080678.
InParanoidi Q86UW7.
OMAi HMKHSGY.
OrthoDBi EOG7K0ZD0.
PhylomeDBi Q86UW7.

Miscellaneous databases

ChiTaRSi CADPS2. human.
GeneWikii CADPS2.
GenomeRNAii 93664.
NextBioi 78208.
PROi Q86UW7.
SOURCEi Search...

Gene expression databases

Bgeei Q86UW7.
CleanExi HS_CAPS2.
ExpressionAtlasi Q86UW7. baseline and differential.
Genevestigatori Q86UW7.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR000008. C2_dom.
IPR010439. Ca-dep_secretion_activator.
IPR014770. Munc13_1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF06292. DUF1041. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
PROSITEi PS51258. MHD1. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function."
    Speidel D., Varoqueaux F., Enk C., Nojiri M., Grishanin R.N., Martin T.F.J., Hofmann K., Brose N., Reim K.
    J. Biol. Chem. 278:52802-52809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family."
    Cisternas F.A., Vincent J.B., Scherer S.W., Ray P.N.
    Genomics 81:279-291(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANT THR-298.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-180.
    Tissue: Brain, Skin and Testis.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-506 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1296 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-1296 (ISOFORM 3).
    Tissue: Hepatoma and Trachea.
  7. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-1296 (ISOFORM 2).
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 262-1296 (ISOFORM 2).
    Tissue: Stomach.
  9. "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)."
    Binda A.V., Kabbani N., Levenson R.
    Biochem. Pharmacol. 69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DRD2.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56 AND SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCAPS2_HUMAN
AccessioniPrimary (citable) accession number: Q86UW7
Secondary accession number(s): A4D0X3
, B7ZM56, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3