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Q86UW2 (OSTB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Organic solute transporter subunit beta

Short name=OST-beta
Alternative name(s):
Solute carrier family 51 subunit beta
Gene names
Name:SLC51B
Synonyms:OSTB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities. Ref.4

Subunit structure

Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane By similarity.

Subcellular location

Cell membrane; Single-pass membrane protein. Note: Mainly restricted to the lateral and basal membranes of ileal enterocytes. Ref.1 Ref.4

Tissue specificity

Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. Ref.1 Ref.4

Induction

Positively regulated via NR1H4/FXR. Ref.5 Ref.6

Domain

The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface By similarity.

Sequence similarities

Belongs to the OST-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 128128Organic solute transporter subunit beta
PRO_0000331554

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5621Helical; Potential
Topological domain57 – 12872Cytoplasmic Potential

Experimental info

Sequence conflict661K → T in AAP23992. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q86UW2 [UniParc].

Last modified April 29, 2008. Version 2.
Checksum: A6D6F9391CB15794

FASTA12814,346
        10         20         30         40         50         60 
MEHSEGAPGD PAGTVVPQEL LEEMLWFFRV EDASPWNHSI LALAAVVVII SMVLLGRSIQ 

        70         80         90        100        110        120 
ASRKEKMQPP EKETPEVLHL DEAKDHNSLN NLRETLLSEK PNLAQVELEL KERDVLSVFL 


PDVPETES 

« Hide

References

« Hide 'large scale' references
[1]"Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta."
Seward D.J., Koh A.S., Boyer J.L., Ballatori N.
J. Biol. Chem. 278:27473-27482(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Liver.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia."
Ballatori N., Christian W.V., Lee J.Y., Dawson P.A., Soroka C.J., Boyer J.L., Madejczyk M.S., Li N.
Hepatology 42:1270-1279(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]"The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes."
Landrier J.-F., Eloranta J.J., Vavricka S.R., Kullak-Ublick G.A.
Am. J. Physiol. 290:G476-G485(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY NR1H4.
[6]"FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine."
Lee H., Zhang Y., Lee F.Y., Nelson S.F., Gonzalez F.J., Edwards P.A.
J. Lipid Res. 47:201-214(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY NR1H4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY194242 mRNA. Translation: AAP23992.1.
CH471082 Genomic DNA. Translation: EAW77708.1.
BC103842 mRNA. Translation: AAI03843.1.
BC103843 mRNA. Translation: AAI03844.1.
BC103844 mRNA. Translation: AAI03845.1.
CCDSCCDS10199.1.
RefSeqNP_849190.2. NM_178859.3.
XP_005254216.1. XM_005254159.2.
UniGeneHs.27018.
Hs.534533.

3D structure databases

ProteinModelPortalQ86UW2.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.82.1.2. the organic solute transporter (ost) family.

PTM databases

PhosphoSiteQ86UW2.

Polymorphism databases

DMDM187471105.

Proteomic databases

PRIDEQ86UW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334287; ENSP00000335292; ENSG00000186198.
GeneID123264.
KEGGhsa:123264.
UCSCuc002aog.3. human.

Organism-specific databases

CTD123264.
GeneCardsGC15P065420.
HGNCHGNC:29956. SLC51B.
HPAHPA008533.
MIM612085. gene.
neXtProtNX_Q86UW2.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44194.
HOGENOMHOG000115298.
HOVERGENHBG095150.
InParanoidQ86UW2.
KOK14361.
OMAQANRNQK.
OrthoDBEOG7XSTH6.
PhylomeDBQ86UW2.

Gene expression databases

BgeeQ86UW2.
GenevestigatorQ86UW2.

Family and domain databases

InterProIPR029387. OSTbeta.
[Graphical view]
PfamPF15048. OSTbeta. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOSTbeta.
GenomeRNAi123264.
NextBio81097.
PROQ86UW2.
SOURCESearch...

Entry information

Entry nameOSTB_HUMAN
AccessionPrimary (citable) accession number: Q86UW2
Secondary accession number(s): Q3SYF5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM