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Protein

Organic solute transporter subunit beta

Gene

SLC51B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.1 Publication

GO - Molecular functioni

  1. protein heterodimerization activity Source: UniProtKB
  2. transporter activity Source: Ensembl

GO - Biological processi

  1. bile acid and bile salt transport Source: UniProtKB
  2. positive regulation of protein exit from endoplasmic reticulum Source: UniProtKB
  3. positive regulation of protein glycosylation Source: UniProtKB
  4. positive regulation of protein targeting to membrane Source: UniProtKB
  5. regulation of protein stability Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.82.1.2. the organic solute transporter (ost) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Organic solute transporter subunit beta
Short name:
OST-beta
Alternative name(s):
Solute carrier family 51 subunit beta
Gene namesi
Name:SLC51B
Synonyms:OSTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29956. SLC51B.

Subcellular locationi

  1. Cell membrane 2 Publications; Single-pass membrane protein 2 Publications

  2. Note: Mainly restricted to the lateral and basal membranes of ileal enterocytes.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Topological domaini57 – 12872CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: MGI
  3. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

DrugBankiDB00286. Conjugated Estrogens.
DB00390. Digoxin.
DB00917. Dinoprostone.

Polymorphism and mutation databases

BioMutaiSLC51B.
DMDMi187471105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Organic solute transporter subunit betaPRO_0000331554Add
BLAST

Proteomic databases

PRIDEiQ86UW2.

PTM databases

PhosphoSiteiQ86UW2.

Expressioni

Tissue specificityi

Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.2 Publications

Inductioni

Positively regulated via NR1H4/FXR.2 Publications

Gene expression databases

BgeeiQ86UW2.
GenevestigatoriQ86UW2.

Organism-specific databases

HPAiHPA008533.

Interactioni

Subunit structurei

Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ86UW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface (By similarity).By similarity

Sequence similaritiesi

Belongs to the OST-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44194.
GeneTreeiENSGT00390000010409.
HOGENOMiHOG000115298.
HOVERGENiHBG095150.
InParanoidiQ86UW2.
KOiK14361.
OMAiEDATPWN.
OrthoDBiEOG7XSTH6.
PhylomeDBiQ86UW2.

Family and domain databases

InterProiIPR029387. OSTbeta.
[Graphical view]
PfamiPF15048. OSTbeta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86UW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHSEGAPGD PAGTVVPQEL LEEMLWFFRV EDASPWNHSI LALAAVVVII
60 70 80 90 100
SMVLLGRSIQ ASRKEKMQPP EKETPEVLHL DEAKDHNSLN NLRETLLSEK
110 120
PNLAQVELEL KERDVLSVFL PDVPETES
Length:128
Mass (Da):14,346
Last modified:April 29, 2008 - v2
Checksum:iA6D6F9391CB15794
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661K → T in AAP23992 (PubMed:12719432).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194242 mRNA. Translation: AAP23992.1.
CH471082 Genomic DNA. Translation: EAW77708.1.
BC103842 mRNA. Translation: AAI03843.1.
BC103843 mRNA. Translation: AAI03844.1.
BC103844 mRNA. Translation: AAI03845.1.
CCDSiCCDS10199.1.
RefSeqiNP_849190.2. NM_178859.3.
XP_005254216.1. XM_005254159.3.
UniGeneiHs.27018.
Hs.534533.

Genome annotation databases

EnsembliENST00000334287; ENSP00000335292; ENSG00000186198.
GeneIDi123264.
KEGGihsa:123264.
UCSCiuc002aog.3. human.

Polymorphism and mutation databases

BioMutaiSLC51B.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194242 mRNA. Translation: AAP23992.1.
CH471082 Genomic DNA. Translation: EAW77708.1.
BC103842 mRNA. Translation: AAI03843.1.
BC103843 mRNA. Translation: AAI03844.1.
BC103844 mRNA. Translation: AAI03845.1.
CCDSiCCDS10199.1.
RefSeqiNP_849190.2. NM_178859.3.
XP_005254216.1. XM_005254159.3.
UniGeneiHs.27018.
Hs.534533.

3D structure databases

ProteinModelPortaliQ86UW2.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

DrugBankiDB00286. Conjugated Estrogens.
DB00390. Digoxin.
DB00917. Dinoprostone.

Protein family/group databases

TCDBi2.A.82.1.2. the organic solute transporter (ost) family.

PTM databases

PhosphoSiteiQ86UW2.

Polymorphism and mutation databases

BioMutaiSLC51B.
DMDMi187471105.

Proteomic databases

PRIDEiQ86UW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334287; ENSP00000335292; ENSG00000186198.
GeneIDi123264.
KEGGihsa:123264.
UCSCiuc002aog.3. human.

Organism-specific databases

CTDi123264.
GeneCardsiGC15P065762.
HGNCiHGNC:29956. SLC51B.
HPAiHPA008533.
MIMi612085. gene.
neXtProtiNX_Q86UW2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44194.
GeneTreeiENSGT00390000010409.
HOGENOMiHOG000115298.
HOVERGENiHBG095150.
InParanoidiQ86UW2.
KOiK14361.
OMAiEDATPWN.
OrthoDBiEOG7XSTH6.
PhylomeDBiQ86UW2.

Miscellaneous databases

GeneWikiiOSTbeta.
GenomeRNAii123264.
NextBioi81097.
PROiQ86UW2.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UW2.
GenevestigatoriQ86UW2.

Family and domain databases

InterProiIPR029387. OSTbeta.
[Graphical view]
PfamiPF15048. OSTbeta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta."
    Seward D.J., Koh A.S., Boyer J.L., Ballatori N.
    J. Biol. Chem. 278:27473-27482(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia."
    Ballatori N., Christian W.V., Lee J.Y., Dawson P.A., Soroka C.J., Boyer J.L., Madejczyk M.S., Li N.
    Hepatology 42:1270-1279(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes."
    Landrier J.-F., Eloranta J.J., Vavricka S.R., Kullak-Ublick G.A.
    Am. J. Physiol. 290:G476-G485(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY NR1H4.
  6. "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine."
    Lee H., Zhang Y., Lee F.Y., Nelson S.F., Gonzalez F.J., Edwards P.A.
    J. Lipid Res. 47:201-214(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY NR1H4.

Entry informationi

Entry nameiOSTB_HUMAN
AccessioniPrimary (citable) accession number: Q86UW2
Secondary accession number(s): Q3SYF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 29, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.