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Q86UW2

- OSTB_HUMAN

UniProt

Q86UW2 - OSTB_HUMAN

Protein

Organic solute transporter subunit beta

Gene

SLC51B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.1 Publication

    GO - Molecular functioni

    1. protein heterodimerization activity Source: UniProtKB
    2. transporter activity Source: Ensembl

    GO - Biological processi

    1. bile acid and bile salt transport Source: UniProtKB
    2. positive regulation of protein exit from endoplasmic reticulum Source: UniProtKB
    3. positive regulation of protein glycosylation Source: UniProtKB
    4. positive regulation of protein targeting to membrane Source: UniProtKB
    5. regulation of protein stability Source: UniProtKB

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.82.1.2. the organic solute transporter (ost) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Organic solute transporter subunit beta
    Short name:
    OST-beta
    Alternative name(s):
    Solute carrier family 51 subunit beta
    Gene namesi
    Name:SLC51B
    Synonyms:OSTB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:29956. SLC51B.

    Subcellular locationi

    Cell membrane 2 Publications; Single-pass membrane protein 2 Publications
    Note: Mainly restricted to the lateral and basal membranes of ileal enterocytes.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: MGI
    3. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 128128Organic solute transporter subunit betaPRO_0000331554Add
    BLAST

    Proteomic databases

    PRIDEiQ86UW2.

    PTM databases

    PhosphoSiteiQ86UW2.

    Expressioni

    Tissue specificityi

    Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.2 Publications

    Inductioni

    Positively regulated via NR1H4/FXR.2 Publications

    Gene expression databases

    BgeeiQ86UW2.
    GenevestigatoriQ86UW2.

    Organism-specific databases

    HPAiHPA008533.

    Interactioni

    Subunit structurei

    Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UW2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini57 – 12872CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface By similarity.By similarity

    Sequence similaritiesi

    Belongs to the OST-beta family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44194.
    HOGENOMiHOG000115298.
    HOVERGENiHBG095150.
    InParanoidiQ86UW2.
    KOiK14361.
    OMAiQANRNQK.
    OrthoDBiEOG7XSTH6.
    PhylomeDBiQ86UW2.

    Family and domain databases

    InterProiIPR029387. OSTbeta.
    [Graphical view]
    PfamiPF15048. OSTbeta. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86UW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHSEGAPGD PAGTVVPQEL LEEMLWFFRV EDASPWNHSI LALAAVVVII    50
    SMVLLGRSIQ ASRKEKMQPP EKETPEVLHL DEAKDHNSLN NLRETLLSEK 100
    PNLAQVELEL KERDVLSVFL PDVPETES 128
    Length:128
    Mass (Da):14,346
    Last modified:April 29, 2008 - v2
    Checksum:iA6D6F9391CB15794
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661K → T in AAP23992. (PubMed:12719432)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY194242 mRNA. Translation: AAP23992.1.
    CH471082 Genomic DNA. Translation: EAW77708.1.
    BC103842 mRNA. Translation: AAI03843.1.
    BC103843 mRNA. Translation: AAI03844.1.
    BC103844 mRNA. Translation: AAI03845.1.
    CCDSiCCDS10199.1.
    RefSeqiNP_849190.2. NM_178859.3.
    XP_005254216.1. XM_005254159.2.
    UniGeneiHs.27018.
    Hs.534533.

    Genome annotation databases

    EnsembliENST00000334287; ENSP00000335292; ENSG00000186198.
    GeneIDi123264.
    KEGGihsa:123264.
    UCSCiuc002aog.3. human.

    Polymorphism databases

    DMDMi187471105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY194242 mRNA. Translation: AAP23992.1 .
    CH471082 Genomic DNA. Translation: EAW77708.1 .
    BC103842 mRNA. Translation: AAI03843.1 .
    BC103843 mRNA. Translation: AAI03844.1 .
    BC103844 mRNA. Translation: AAI03845.1 .
    CCDSi CCDS10199.1.
    RefSeqi NP_849190.2. NM_178859.3.
    XP_005254216.1. XM_005254159.2.
    UniGenei Hs.27018.
    Hs.534533.

    3D structure databases

    ProteinModelPortali Q86UW2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.82.1.2. the organic solute transporter (ost) family.

    PTM databases

    PhosphoSitei Q86UW2.

    Polymorphism databases

    DMDMi 187471105.

    Proteomic databases

    PRIDEi Q86UW2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334287 ; ENSP00000335292 ; ENSG00000186198 .
    GeneIDi 123264.
    KEGGi hsa:123264.
    UCSCi uc002aog.3. human.

    Organism-specific databases

    CTDi 123264.
    GeneCardsi GC15P065420.
    HGNCi HGNC:29956. SLC51B.
    HPAi HPA008533.
    MIMi 612085. gene.
    neXtProti NX_Q86UW2.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44194.
    HOGENOMi HOG000115298.
    HOVERGENi HBG095150.
    InParanoidi Q86UW2.
    KOi K14361.
    OMAi QANRNQK.
    OrthoDBi EOG7XSTH6.
    PhylomeDBi Q86UW2.

    Miscellaneous databases

    GeneWikii OSTbeta.
    GenomeRNAii 123264.
    NextBioi 81097.
    PROi Q86UW2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86UW2.
    Genevestigatori Q86UW2.

    Family and domain databases

    InterProi IPR029387. OSTbeta.
    [Graphical view ]
    Pfami PF15048. OSTbeta. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta."
      Seward D.J., Koh A.S., Boyer J.L., Ballatori N.
      J. Biol. Chem. 278:27473-27482(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia."
      Ballatori N., Christian W.V., Lee J.Y., Dawson P.A., Soroka C.J., Boyer J.L., Madejczyk M.S., Li N.
      Hepatology 42:1270-1279(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes."
      Landrier J.-F., Eloranta J.J., Vavricka S.R., Kullak-Ublick G.A.
      Am. J. Physiol. 290:G476-G485(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY NR1H4.
    6. "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine."
      Lee H., Zhang Y., Lee F.Y., Nelson S.F., Gonzalez F.J., Edwards P.A.
      J. Lipid Res. 47:201-214(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY NR1H4.

    Entry informationi

    Entry nameiOSTB_HUMAN
    AccessioniPrimary (citable) accession number: Q86UW2
    Secondary accession number(s): Q3SYF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3