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Q86UW1

- OSTA_HUMAN

UniProt

Q86UW1 - OSTA_HUMAN

Protein

Organic solute transporter subunit alpha

Gene

SLC51A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.1 Publication

    GO - Molecular functioni

    1. protein heterodimerization activity Source: UniProtKB
    2. protein homodimerization activity Source: UniProtKB
    3. transporter activity Source: UniProtKB

    GO - Biological processi

    1. bile acid and bile salt transport Source: UniProtKB
    2. transport Source: UniProtKB

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.82.1.2. the organic solute transporter (ost) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Organic solute transporter subunit alpha
    Short name:
    OST-alpha
    Alternative name(s):
    Solute carrier family 51 subunit alpha
    Gene namesi
    Name:SLC51A
    Synonyms:OSTA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:29955. SLC51A.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
    Note: Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B By similarity. Mainly restricted to the lateral and basal membranes of ileal enterocytes.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB
    3. plasma membrane Source: MGI
    4. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Organic solute transporter subunit alphaPRO_0000331543Add
    BLAST

    Proteomic databases

    PaxDbiQ86UW1.
    PRIDEiQ86UW1.

    PTM databases

    PhosphoSiteiQ86UW1.

    Expressioni

    Tissue specificityi

    Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.2 Publications

    Inductioni

    Positively regulated via NR1H4/FXR in adrenal gland, kidney and intestine.2 Publications

    Gene expression databases

    ArrayExpressiQ86UW1.
    BgeeiQ86UW1.
    GenevestigatoriQ86UW1.

    Organism-specific databases

    HPAiHPA039123.

    Interactioni

    Subunit structurei

    Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit By similarity.By similarity

    Protein-protein interaction databases

    BioGridi128357. 1 interaction.
    IntActiQ86UW1. 1 interaction.
    MINTiMINT-2879111.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4848ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini70 – 8718CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 11810ExtracellularSequence Analysis
    Topological domaini140 – 18142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini203 – 21816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 25516CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 29418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini318 – 34023CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi160 – 1678Poly-Cys

    Sequence similaritiesi

    Belongs to the OST-alpha family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85003.
    HOGENOMiHOG000115297.
    HOVERGENiHBG098275.
    InParanoidiQ86UW1.
    KOiK14360.
    OMAiLTRMYYR.
    PhylomeDBiQ86UW1.

    Family and domain databases

    InterProiIPR005178. Ostalpha/TMEM184C.
    [Graphical view]
    PANTHERiPTHR23423. PTHR23423. 1 hit.
    PfamiPF03619. Solute_trans_a. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86UW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGRTQIKL DPRYTADLLE VLKTNYGIPS ACFSQPPTAA QLLRALGPVE    50
    LALTSILTLL ALGSIAIFLE DAVYLYKNTL CPIKRRTLLW KSSAPTVVSV 100
    LCCFGLWIPR SLVLVEMTIT SFYAVCFYLL MLVMVEGFGG KEAVLRTLRD 150
    TPMMVHTGPC CCCCPCCPRL LLTRKKLQLL MLGPFQYAFL KITLTLVGLF 200
    LVPDGIYDPA DISEGSTALW INTFLGVSTL LALWTLGIIS RQARLHLGEQ 250
    NMGAKFALFQ VLLILTALQP SIFSVLANGG QIACSPPYSS KTRSQVMNCH 300
    LLILETFLMT VLTRMYYRRK DHKVGYETFS SPDLDLNLKA 340
    Length:340
    Mass (Da):37,735
    Last modified:June 1, 2003 - v1
    Checksum:iD6725C479A7DF114
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti202 – 2021V → I.1 Publication
    Corresponds to variant rs939885 [ dbSNP | Ensembl ].
    VAR_042895

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY194243 mRNA. Translation: AAP23993.1.
    AK172837 mRNA. Translation: BAD18802.1.
    CH471191 Genomic DNA. Translation: EAW53665.1.
    CCDSiCCDS3314.1.
    RefSeqiNP_689885.4. NM_152672.5.
    UniGeneiHs.630585.

    Genome annotation databases

    EnsembliENST00000296327; ENSP00000296327; ENSG00000163959.
    GeneIDi200931.
    KEGGihsa:200931.
    UCSCiuc003fwd.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY194243 mRNA. Translation: AAP23993.1 .
    AK172837 mRNA. Translation: BAD18802.1 .
    CH471191 Genomic DNA. Translation: EAW53665.1 .
    CCDSi CCDS3314.1.
    RefSeqi NP_689885.4. NM_152672.5.
    UniGenei Hs.630585.

    3D structure databases

    ProteinModelPortali Q86UW1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128357. 1 interaction.
    IntActi Q86UW1. 1 interaction.
    MINTi MINT-2879111.

    Chemistry

    ChEMBLi CHEMBL2073724.

    Protein family/group databases

    TCDBi 2.A.82.1.2. the organic solute transporter (ost) family.

    PTM databases

    PhosphoSitei Q86UW1.

    Proteomic databases

    PaxDbi Q86UW1.
    PRIDEi Q86UW1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296327 ; ENSP00000296327 ; ENSG00000163959 .
    GeneIDi 200931.
    KEGGi hsa:200931.
    UCSCi uc003fwd.3. human.

    Organism-specific databases

    CTDi 200931.
    GeneCardsi GC03P195939.
    H-InvDB HIX0003964.
    HGNCi HGNC:29955. SLC51A.
    HPAi HPA039123.
    MIMi 612084. gene.
    neXtProti NX_Q86UW1.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85003.
    HOGENOMi HOG000115297.
    HOVERGENi HBG098275.
    InParanoidi Q86UW1.
    KOi K14360.
    OMAi LTRMYYR.
    PhylomeDBi Q86UW1.

    Miscellaneous databases

    GeneWikii OSTalpha.
    GenomeRNAii 200931.
    NextBioi 90016.
    PROi Q86UW1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UW1.
    Bgeei Q86UW1.
    Genevestigatori Q86UW1.

    Family and domain databases

    InterProi IPR005178. Ostalpha/TMEM184C.
    [Graphical view ]
    PANTHERi PTHR23423. PTHR23423. 1 hit.
    Pfami PF03619. Solute_trans_a. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta."
      Seward D.J., Koh A.S., Boyer J.L., Ballatori N.
      J. Biol. Chem. 278:27473-27482(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-202.
      Tissue: Small intestine.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia."
      Ballatori N., Christian W.V., Lee J.Y., Dawson P.A., Soroka C.J., Boyer J.L., Madejczyk M.S., Li N.
      Hepatology 42:1270-1279(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes."
      Landrier J.-F., Eloranta J.J., Vavricka S.R., Kullak-Ublick G.A.
      Am. J. Physiol. 290:G476-G485(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY NR1H4.
    6. "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine."
      Lee H., Zhang Y., Lee F.Y., Nelson S.F., Gonzalez F.J., Edwards P.A.
      J. Lipid Res. 47:201-214(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY NR1H4.

    Entry informationi

    Entry nameiOSTA_HUMAN
    AccessioniPrimary (citable) accession number: Q86UW1
    Secondary accession number(s): Q6ZMC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3