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Q86UW1

- OSTA_HUMAN

UniProt

Q86UW1 - OSTA_HUMAN

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Protein

Organic solute transporter subunit alpha

Gene

SLC51A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.1 Publication

GO - Molecular functioni

  1. protein heterodimerization activity Source: UniProtKB
  2. protein homodimerization activity Source: UniProtKB
  3. transporter activity Source: UniProtKB

GO - Biological processi

  1. bile acid and bile salt transport Source: UniProtKB
  2. transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.82.1.2. the organic solute transporter (ost) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Organic solute transporter subunit alpha
Short name:
OST-alpha
Alternative name(s):
Solute carrier family 51 subunit alpha
Gene namesi
Name:SLC51A
Synonyms:OSTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:29955. SLC51A.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Note: Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: MGI
  4. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Organic solute transporter subunit alphaPRO_0000331543Add
BLAST

Proteomic databases

PaxDbiQ86UW1.
PRIDEiQ86UW1.

PTM databases

PhosphoSiteiQ86UW1.

Expressioni

Tissue specificityi

Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.2 Publications

Inductioni

Positively regulated via NR1H4/FXR in adrenal gland, kidney and intestine.2 Publications

Gene expression databases

BgeeiQ86UW1.
ExpressionAtlasiQ86UW1. baseline and differential.
GenevestigatoriQ86UW1.

Organism-specific databases

HPAiHPA039123.

Interactioni

Subunit structurei

Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit (By similarity).By similarity

Protein-protein interaction databases

BioGridi128357. 1 interaction.
IntActiQ86UW1. 1 interaction.
MINTiMINT-2879111.

Structurei

3D structure databases

ProteinModelPortaliQ86UW1.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularSequence AnalysisAdd
BLAST
Topological domaini70 – 8718CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini109 – 11810ExtracellularSequence Analysis
Topological domaini140 – 18142CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini203 – 21816ExtracellularSequence AnalysisAdd
BLAST
Topological domaini240 – 25516CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini277 – 29418ExtracellularSequence AnalysisAdd
BLAST
Topological domaini318 – 34023CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence AnalysisAdd
BLAST
Transmembranei295 – 31723HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi160 – 1678Poly-Cys

Sequence similaritiesi

Belongs to the OST-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85003.
GeneTreeiENSGT00640000091510.
HOGENOMiHOG000115297.
HOVERGENiHBG098275.
InParanoidiQ86UW1.
KOiK14360.
OMAiLTRMYYR.
PhylomeDBiQ86UW1.

Family and domain databases

InterProiIPR005178. Ostalpha/TMEM184C.
[Graphical view]
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiPF03619. Solute_trans_a. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86UW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPGRTQIKL DPRYTADLLE VLKTNYGIPS ACFSQPPTAA QLLRALGPVE
60 70 80 90 100
LALTSILTLL ALGSIAIFLE DAVYLYKNTL CPIKRRTLLW KSSAPTVVSV
110 120 130 140 150
LCCFGLWIPR SLVLVEMTIT SFYAVCFYLL MLVMVEGFGG KEAVLRTLRD
160 170 180 190 200
TPMMVHTGPC CCCCPCCPRL LLTRKKLQLL MLGPFQYAFL KITLTLVGLF
210 220 230 240 250
LVPDGIYDPA DISEGSTALW INTFLGVSTL LALWTLGIIS RQARLHLGEQ
260 270 280 290 300
NMGAKFALFQ VLLILTALQP SIFSVLANGG QIACSPPYSS KTRSQVMNCH
310 320 330 340
LLILETFLMT VLTRMYYRRK DHKVGYETFS SPDLDLNLKA
Length:340
Mass (Da):37,735
Last modified:June 1, 2003 - v1
Checksum:iD6725C479A7DF114
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021V → I.1 Publication
Corresponds to variant rs939885 [ dbSNP | Ensembl ].
VAR_042895

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY194243 mRNA. Translation: AAP23993.1.
AK172837 mRNA. Translation: BAD18802.1.
CH471191 Genomic DNA. Translation: EAW53665.1.
CCDSiCCDS3314.1.
RefSeqiNP_689885.4. NM_152672.5.
UniGeneiHs.630585.

Genome annotation databases

EnsembliENST00000296327; ENSP00000296327; ENSG00000163959.
GeneIDi200931.
KEGGihsa:200931.
UCSCiuc003fwd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY194243 mRNA. Translation: AAP23993.1 .
AK172837 mRNA. Translation: BAD18802.1 .
CH471191 Genomic DNA. Translation: EAW53665.1 .
CCDSi CCDS3314.1.
RefSeqi NP_689885.4. NM_152672.5.
UniGenei Hs.630585.

3D structure databases

ProteinModelPortali Q86UW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128357. 1 interaction.
IntActi Q86UW1. 1 interaction.
MINTi MINT-2879111.

Chemistry

ChEMBLi CHEMBL2073724.
DrugBanki DB00286. Conjugated Estrogens.
DB00390. Digoxin.
DB00917. Dinoprostone.

Protein family/group databases

TCDBi 2.A.82.1.2. the organic solute transporter (ost) family.

PTM databases

PhosphoSitei Q86UW1.

Proteomic databases

PaxDbi Q86UW1.
PRIDEi Q86UW1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296327 ; ENSP00000296327 ; ENSG00000163959 .
GeneIDi 200931.
KEGGi hsa:200931.
UCSCi uc003fwd.3. human.

Organism-specific databases

CTDi 200931.
GeneCardsi GC03P195939.
H-InvDB HIX0003964.
HGNCi HGNC:29955. SLC51A.
HPAi HPA039123.
MIMi 612084. gene.
neXtProti NX_Q86UW1.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85003.
GeneTreei ENSGT00640000091510.
HOGENOMi HOG000115297.
HOVERGENi HBG098275.
InParanoidi Q86UW1.
KOi K14360.
OMAi LTRMYYR.
PhylomeDBi Q86UW1.

Miscellaneous databases

GeneWikii OSTalpha.
GenomeRNAii 200931.
NextBioi 90016.
PROi Q86UW1.
SOURCEi Search...

Gene expression databases

Bgeei Q86UW1.
ExpressionAtlasi Q86UW1. baseline and differential.
Genevestigatori Q86UW1.

Family and domain databases

InterProi IPR005178. Ostalpha/TMEM184C.
[Graphical view ]
PANTHERi PTHR23423. PTHR23423. 1 hit.
Pfami PF03619. Solute_trans_a. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta."
    Seward D.J., Koh A.S., Boyer J.L., Ballatori N.
    J. Biol. Chem. 278:27473-27482(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-202.
    Tissue: Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia."
    Ballatori N., Christian W.V., Lee J.Y., Dawson P.A., Soroka C.J., Boyer J.L., Madejczyk M.S., Li N.
    Hepatology 42:1270-1279(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes."
    Landrier J.-F., Eloranta J.J., Vavricka S.R., Kullak-Ublick G.A.
    Am. J. Physiol. 290:G476-G485(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY NR1H4.
  6. "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine."
    Lee H., Zhang Y., Lee F.Y., Nelson S.F., Gonzalez F.J., Edwards P.A.
    J. Lipid Res. 47:201-214(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY NR1H4.

Entry informationi

Entry nameiOSTA_HUMAN
AccessioniPrimary (citable) accession number: Q86UW1
Secondary accession number(s): Q6ZMC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3