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Q86UW1 (OSTA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Organic solute transporter subunit alpha

Short name=OST-alpha
Alternative name(s):
Solute carrier family 51 subunit alpha
Gene names
Name:SLC51A
Synonyms:OSTA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Ref.4

Subunit structure

Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Note: Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B By similarity. Mainly restricted to the lateral and basal membranes of ileal enterocytes. Ref.1 Ref.4

Tissue specificity

Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. Ref.1 Ref.4

Induction

Positively regulated via NR1H4/FXR in adrenal gland, kidney and intestine. Ref.5 Ref.6

Sequence similarities

Belongs to the OST-alpha family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Organic solute transporter subunit alpha
PRO_0000331543

Regions

Topological domain1 – 4848Extracellular Potential
Transmembrane49 – 6921Helical; Potential
Topological domain70 – 8718Cytoplasmic Potential
Transmembrane88 – 10821Helical; Potential
Topological domain109 – 11810Extracellular Potential
Transmembrane119 – 13921Helical; Potential
Topological domain140 – 18142Cytoplasmic Potential
Transmembrane182 – 20221Helical; Potential
Topological domain203 – 21816Extracellular Potential
Transmembrane219 – 23921Helical; Potential
Topological domain240 – 25516Cytoplasmic Potential
Transmembrane256 – 27621Helical; Potential
Topological domain277 – 29418Extracellular Potential
Transmembrane295 – 31723Helical; Potential
Topological domain318 – 34023Cytoplasmic Potential
Compositional bias160 – 1678Poly-Cys

Natural variations

Natural variant2021V → I. Ref.2
Corresponds to variant rs939885 [ dbSNP | Ensembl ].
VAR_042895

Sequences

Sequence LengthMass (Da)Tools
Q86UW1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: D6725C479A7DF114

FASTA34037,735
        10         20         30         40         50         60 
MEPGRTQIKL DPRYTADLLE VLKTNYGIPS ACFSQPPTAA QLLRALGPVE LALTSILTLL 

        70         80         90        100        110        120 
ALGSIAIFLE DAVYLYKNTL CPIKRRTLLW KSSAPTVVSV LCCFGLWIPR SLVLVEMTIT 

       130        140        150        160        170        180 
SFYAVCFYLL MLVMVEGFGG KEAVLRTLRD TPMMVHTGPC CCCCPCCPRL LLTRKKLQLL 

       190        200        210        220        230        240 
MLGPFQYAFL KITLTLVGLF LVPDGIYDPA DISEGSTALW INTFLGVSTL LALWTLGIIS 

       250        260        270        280        290        300 
RQARLHLGEQ NMGAKFALFQ VLLILTALQP SIFSVLANGG QIACSPPYSS KTRSQVMNCH 

       310        320        330        340 
LLILETFLMT VLTRMYYRRK DHKVGYETFS SPDLDLNLKA 

« Hide

References

« Hide 'large scale' references
[1]"Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta."
Seward D.J., Koh A.S., Boyer J.L., Ballatori N.
J. Biol. Chem. 278:27473-27482(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Liver.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-202.
Tissue: Small intestine.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia."
Ballatori N., Christian W.V., Lee J.Y., Dawson P.A., Soroka C.J., Boyer J.L., Madejczyk M.S., Li N.
Hepatology 42:1270-1279(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]"The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes."
Landrier J.-F., Eloranta J.J., Vavricka S.R., Kullak-Ublick G.A.
Am. J. Physiol. 290:G476-G485(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY NR1H4.
[6]"FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine."
Lee H., Zhang Y., Lee F.Y., Nelson S.F., Gonzalez F.J., Edwards P.A.
J. Lipid Res. 47:201-214(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY NR1H4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY194243 mRNA. Translation: AAP23993.1.
AK172837 mRNA. Translation: BAD18802.1.
CH471191 Genomic DNA. Translation: EAW53665.1.
RefSeqNP_689885.4. NM_152672.5.
UniGeneHs.630585.

3D structure databases

ProteinModelPortalQ86UW1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128357. 1 interaction.
IntActQ86UW1. 1 interaction.
MINTMINT-2879111.

Chemistry

ChEMBLCHEMBL2073724.

Protein family/group databases

TCDB2.A.82.1.2. the organic solute transporter (ost) family.

PTM databases

PhosphoSiteQ86UW1.

Proteomic databases

PaxDbQ86UW1.
PRIDEQ86UW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296327; ENSP00000296327; ENSG00000163959.
GeneID200931.
KEGGhsa:200931.
UCSCuc003fwd.3. human.

Organism-specific databases

CTD200931.
GeneCardsGC03P195939.
H-InvDBHIX0003964.
HGNCHGNC:29955. SLC51A.
HPAHPA039123.
MIM612084. gene.
neXtProtNX_Q86UW1.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85003.
HOGENOMHOG000115297.
HOVERGENHBG098275.
InParanoidQ86UW1.
KOK14360.
OMALTRMYYR.
PhylomeDBQ86UW1.

Gene expression databases

ArrayExpressQ86UW1.
BgeeQ86UW1.
GenevestigatorQ86UW1.

Family and domain databases

InterProIPR005178. Ost-alpha.
[Graphical view]
PANTHERPTHR23423. PTHR23423. 1 hit.
PfamPF03619. Solute_trans_a. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOSTalpha.
GenomeRNAi200931.
NextBio90016.
PROQ86UW1.
SOURCESearch...

Entry information

Entry nameOSTA_HUMAN
AccessionPrimary (citable) accession number: Q86UW1
Secondary accession number(s): Q6ZMC7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM