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Protein

Organic solute transporter subunit alpha

Gene

SLC51A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.1 Publication

GO - Molecular functioni

GO - Biological processi

  • bile acid and bile salt transport Source: UniProtKB
  • transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.82.1.2. the organic solute transporter (ost) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Organic solute transporter subunit alpha
Short name:
OST-alpha
Alternative name(s):
Solute carrier family 51 subunit alpha
Gene namesi
Name:SLC51A
Synonyms:OSTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29955. SLC51A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 87CytoplasmicSequence analysisAdd BLAST18
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 118ExtracellularSequence analysis10
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 181CytoplasmicSequence analysisAdd BLAST42
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 218ExtracellularSequence analysisAdd BLAST16
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 255CytoplasmicSequence analysisAdd BLAST16
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 294ExtracellularSequence analysisAdd BLAST18
Transmembranei295 – 317HelicalSequence analysisAdd BLAST23
Topological domaini318 – 340CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi200931.
OpenTargetsiENSG00000163959.

Chemistry databases

ChEMBLiCHEMBL2073724.
DrugBankiDB00286. Conjugated Estrogens.
DB00390. Digoxin.
DB00917. Dinoprostone.

Polymorphism and mutation databases

BioMutaiSLC51A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315431 – 340Organic solute transporter subunit alphaAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei330PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ86UW1.
PeptideAtlasiQ86UW1.
PRIDEiQ86UW1.

PTM databases

iPTMnetiQ86UW1.
PhosphoSitePlusiQ86UW1.

Expressioni

Tissue specificityi

Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.2 Publications

Inductioni

Positively regulated via NR1H4/FXR in adrenal gland, kidney and intestine.2 Publications

Gene expression databases

BgeeiENSG00000163959.
ExpressionAtlasiQ86UW1. baseline and differential.
GenevisibleiQ86UW1. HS.

Organism-specific databases

HPAiHPA039123.

Interactioni

Subunit structurei

Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128357. 6 interactors.
IntActiQ86UW1. 1 interactor.
MINTiMINT-2879111.
STRINGi9606.ENSP00000296327.

Structurei

3D structure databases

ProteinModelPortaliQ86UW1.
SMRiQ86UW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 167Poly-Cys8

Sequence similaritiesi

Belongs to the OST-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKZG. Eukaryota.
ENOG410XW07. LUCA.
GeneTreeiENSGT00640000091510.
HOGENOMiHOG000115297.
HOVERGENiHBG098275.
InParanoidiQ86UW1.
KOiK14360.
OMAiFMVGGPV.
OrthoDBiEOG091G0CFZ.
PhylomeDBiQ86UW1.

Family and domain databases

InterProiIPR005178. Ostalpha/TMEM184C.
[Graphical view]
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiPF03619. Solute_trans_a. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86UW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGRTQIKL DPRYTADLLE VLKTNYGIPS ACFSQPPTAA QLLRALGPVE
60 70 80 90 100
LALTSILTLL ALGSIAIFLE DAVYLYKNTL CPIKRRTLLW KSSAPTVVSV
110 120 130 140 150
LCCFGLWIPR SLVLVEMTIT SFYAVCFYLL MLVMVEGFGG KEAVLRTLRD
160 170 180 190 200
TPMMVHTGPC CCCCPCCPRL LLTRKKLQLL MLGPFQYAFL KITLTLVGLF
210 220 230 240 250
LVPDGIYDPA DISEGSTALW INTFLGVSTL LALWTLGIIS RQARLHLGEQ
260 270 280 290 300
NMGAKFALFQ VLLILTALQP SIFSVLANGG QIACSPPYSS KTRSQVMNCH
310 320 330 340
LLILETFLMT VLTRMYYRRK DHKVGYETFS SPDLDLNLKA
Length:340
Mass (Da):37,735
Last modified:June 1, 2003 - v1
Checksum:iD6725C479A7DF114
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042895202V → I.1 PublicationCorresponds to variant rs939885dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194243 mRNA. Translation: AAP23993.1.
AK172837 mRNA. Translation: BAD18802.1.
CH471191 Genomic DNA. Translation: EAW53665.1.
CCDSiCCDS3314.1.
RefSeqiNP_689885.4. NM_152672.5.
UniGeneiHs.630585.

Genome annotation databases

EnsembliENST00000296327; ENSP00000296327; ENSG00000163959.
GeneIDi200931.
KEGGihsa:200931.
UCSCiuc003fwd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194243 mRNA. Translation: AAP23993.1.
AK172837 mRNA. Translation: BAD18802.1.
CH471191 Genomic DNA. Translation: EAW53665.1.
CCDSiCCDS3314.1.
RefSeqiNP_689885.4. NM_152672.5.
UniGeneiHs.630585.

3D structure databases

ProteinModelPortaliQ86UW1.
SMRiQ86UW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128357. 6 interactors.
IntActiQ86UW1. 1 interactor.
MINTiMINT-2879111.
STRINGi9606.ENSP00000296327.

Chemistry databases

ChEMBLiCHEMBL2073724.
DrugBankiDB00286. Conjugated Estrogens.
DB00390. Digoxin.
DB00917. Dinoprostone.

Protein family/group databases

TCDBi2.A.82.1.2. the organic solute transporter (ost) family.

PTM databases

iPTMnetiQ86UW1.
PhosphoSitePlusiQ86UW1.

Polymorphism and mutation databases

BioMutaiSLC51A.

Proteomic databases

PaxDbiQ86UW1.
PeptideAtlasiQ86UW1.
PRIDEiQ86UW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296327; ENSP00000296327; ENSG00000163959.
GeneIDi200931.
KEGGihsa:200931.
UCSCiuc003fwd.4. human.

Organism-specific databases

CTDi200931.
DisGeNETi200931.
GeneCardsiSLC51A.
H-InvDBHIX0003964.
HGNCiHGNC:29955. SLC51A.
HPAiHPA039123.
MIMi612084. gene.
neXtProtiNX_Q86UW1.
OpenTargetsiENSG00000163959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKZG. Eukaryota.
ENOG410XW07. LUCA.
GeneTreeiENSGT00640000091510.
HOGENOMiHOG000115297.
HOVERGENiHBG098275.
InParanoidiQ86UW1.
KOiK14360.
OMAiFMVGGPV.
OrthoDBiEOG091G0CFZ.
PhylomeDBiQ86UW1.

Miscellaneous databases

GeneWikiiOSTalpha.
GenomeRNAii200931.
PROiQ86UW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163959.
ExpressionAtlasiQ86UW1. baseline and differential.
GenevisibleiQ86UW1. HS.

Family and domain databases

InterProiIPR005178. Ostalpha/TMEM184C.
[Graphical view]
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiPF03619. Solute_trans_a. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTA_HUMAN
AccessioniPrimary (citable) accession number: Q86UW1
Secondary accession number(s): Q6ZMC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.