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Q86UV6

- TRI74_HUMAN

UniProt

Q86UV6 - TRI74_HUMAN

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Protein
Tripartite motif-containing protein 74
Gene
TRIM74, TRIM50C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 5742RING-type
Add
BLAST
Zinc fingeri84 – 12542B box-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 74
Alternative name(s):
Tripartite motif-containing protein 50C
Gene namesi
Name:TRIM74
Synonyms:TRIM50C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:17453. TRIM74.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Tripartite motif-containing protein 74
PRO_0000056279Add
BLAST

Proteomic databases

PRIDEiQ86UV6.

Expressioni

Gene expression databases

BgeeiQ86UV6.
CleanExiHS_TRIM74.
GenevestigatoriQ86UV6.

Interactioni

Protein-protein interaction databases

BioGridi132031. 11 interactions.
IntActiQ86UV6. 8 interactions.
STRINGi9606.ENSP00000285805.

Structurei

3D structure databases

ProteinModelPortaliQ86UV6.
SMRiQ86UV6. Positions 10-59.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili125 – 16945 Reviewed prediction
Add
BLAST
Coiled coili204 – 23532 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000081784.
HOVERGENiHBG094091.
InParanoidiQ86UV6.
KOiK12024.
OrthoDBiEOG74R1QB.
PhylomeDBiQ86UV6.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86UV6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAWQVSLLEL EDWLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK    50
VRCPMCWQVV DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC 100
EKDQELICGL CGLLGSHQHH PVTPVSTVCS RMKEELAALF SELKQEQKKV 150
DELIAKLVKN RTRIVNESDV FSWVIRREFQ ELRHPVDEEK ARCLEGIGGH 200
TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF IWKFHSMASR 250
Length:250
Mass (Da):28,547
Last modified:June 1, 2003 - v1
Checksum:i6B2F10940B04AC2B
GO
Isoform 2 (identifier: Q86UV6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-243: Missing.

Note: No experimental confirmation available.

Show »
Length:249
Mass (Da):28,419
Checksum:i5EB8FF5830F401E7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131W → R.1 Publication
Corresponds to variant rs121966 [ dbSNP | Ensembl ].
VAR_039576

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei243 – 2431Missing in isoform 2.
VSP_032087

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281V → I in AAH33871. 1 Publication
Sequence conflicti159 – 1591K → N in AAH33871. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498999 mRNA. Translation: AAP30736.1.
AC005488 Genomic DNA. No translation available.
BC033871 mRNA. Translation: AAH33871.1.
CCDSiCCDS5545.1. [Q86UV6-1]
RefSeqiNP_942150.1. NM_198853.1. [Q86UV6-1]
XP_006716043.1. XM_006715980.1. [Q86UV6-2]
UniGeneiHs.645328.

Genome annotation databases

EnsembliENST00000285805; ENSP00000285805; ENSG00000155428. [Q86UV6-1]
ENST00000395244; ENSP00000378665; ENSG00000155428. [Q86UV6-2]
ENST00000571453; ENSP00000458771; ENSG00000262421. [Q86UV6-2]
ENST00000573986; ENSP00000458390; ENSG00000262421. [Q86UV6-1]
GeneIDi378108.
KEGGihsa:378108.
UCSCiuc003tws.1. human. [Q86UV6-2]
uc022afm.1. human. [Q86UV6-1]

Polymorphism databases

DMDMi56404879.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498999 mRNA. Translation: AAP30736.1 .
AC005488 Genomic DNA. No translation available.
BC033871 mRNA. Translation: AAH33871.1 .
CCDSi CCDS5545.1. [Q86UV6-1 ]
RefSeqi NP_942150.1. NM_198853.1. [Q86UV6-1 ]
XP_006716043.1. XM_006715980.1. [Q86UV6-2 ]
UniGenei Hs.645328.

3D structure databases

ProteinModelPortali Q86UV6.
SMRi Q86UV6. Positions 10-59.
ModBasei Search...

Protein-protein interaction databases

BioGridi 132031. 11 interactions.
IntActi Q86UV6. 8 interactions.
STRINGi 9606.ENSP00000285805.

Polymorphism databases

DMDMi 56404879.

Proteomic databases

PRIDEi Q86UV6.

Protocols and materials databases

DNASUi 378108.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285805 ; ENSP00000285805 ; ENSG00000155428 . [Q86UV6-1 ]
ENST00000395244 ; ENSP00000378665 ; ENSG00000155428 . [Q86UV6-2 ]
ENST00000571453 ; ENSP00000458771 ; ENSG00000262421 . [Q86UV6-2 ]
ENST00000573986 ; ENSP00000458390 ; ENSG00000262421 . [Q86UV6-1 ]
GeneIDi 378108.
KEGGi hsa:378108.
UCSCi uc003tws.1. human. [Q86UV6-2 ]
uc022afm.1. human. [Q86UV6-1 ]

Organism-specific databases

CTDi 378108.
GeneCardsi GC07M072430.
HGNCi HGNC:17453. TRIM74.
MIMi 612550. gene.
neXtProti NX_Q86UV6.
PharmGKBi PA38454.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000081784.
HOVERGENi HBG094091.
InParanoidi Q86UV6.
KOi K12024.
OrthoDBi EOG74R1QB.
PhylomeDBi Q86UV6.
TreeFami TF342569.

Miscellaneous databases

GenomeRNAii 378108.
NextBioi 100709.
PROi Q86UV6.
SOURCEi Search...

Gene expression databases

Bgeei Q86UV6.
CleanExi HS_TRIM74.
Genevestigatori Q86UV6.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view ]
SMARTi SM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-13.
    Tissue: Lung.

Entry informationi

Entry nameiTRI74_HUMAN
AccessioniPrimary (citable) accession number: Q86UV6
Secondary accession number(s): B7WP46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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