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Protein

Tripartite motif-containing protein 74

Gene

TRIM74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 5742RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri84 – 12542B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 74
Alternative name(s):
Tripartite motif-containing protein 50C
Gene namesi
Name:TRIM74
Synonyms:TRIM50C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:17453. TRIM74.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38454.

Polymorphism and mutation databases

BioMutaiTRIM74.
DMDMi56404879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Tripartite motif-containing protein 74PRO_0000056279Add
BLAST

Proteomic databases

PRIDEiQ86UV6.

Expressioni

Gene expression databases

BgeeiQ86UV6.
CleanExiHS_TRIM74.
GenevisibleiQ86UV6. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10259086,EBI-307352

Protein-protein interaction databases

BioGridi132031. 13 interactions.
IntActiQ86UV6. 9 interactions.
STRINGi9606.ENSP00000285805.

Structurei

3D structure databases

ProteinModelPortaliQ86UV6.
SMRiQ86UV6. Positions 10-59, 89-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili125 – 16945Sequence AnalysisAdd
BLAST
Coiled coili204 – 23532Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 5742RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri84 – 12542B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118838.
HOGENOMiHOG000081784.
HOVERGENiHBG094091.
InParanoidiQ86UV6.
KOiK12024.
OMAiCHRDAEL.
OrthoDBiEOG74R1QB.
PhylomeDBiQ86UV6.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWQVSLLEL EDWLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK
60 70 80 90 100
VRCPMCWQVV DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC
110 120 130 140 150
EKDQELICGL CGLLGSHQHH PVTPVSTVCS RMKEELAALF SELKQEQKKV
160 170 180 190 200
DELIAKLVKN RTRIVNESDV FSWVIRREFQ ELRHPVDEEK ARCLEGIGGH
210 220 230 240 250
TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF IWKFHSMASR
Length:250
Mass (Da):28,547
Last modified:June 1, 2003 - v1
Checksum:i6B2F10940B04AC2B
GO
Isoform 2 (identifier: Q86UV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-243: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):28,419
Checksum:i5EB8FF5830F401E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281V → I in AAH33871 (PubMed:15489334).Curated
Sequence conflicti159 – 1591K → N in AAH33871 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131W → R.1 Publication
Corresponds to variant rs121966 [ dbSNP | Ensembl ].
VAR_039576

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei243 – 2431Missing in isoform 2. 1 PublicationVSP_032087

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498999 mRNA. Translation: AAP30736.1.
AC005488 Genomic DNA. No translation available.
BC033871 mRNA. Translation: AAH33871.1.
CCDSiCCDS5545.1. [Q86UV6-1]
RefSeqiNP_942150.1. NM_198853.1. [Q86UV6-1]
XP_006716043.1. XM_006715980.2. [Q86UV6-2]
XP_011514489.1. XM_011516187.1. [Q86UV6-1]
XP_011514490.1. XM_011516188.1. [Q86UV6-1]
XP_011514491.1. XM_011516189.1. [Q86UV6-2]
UniGeneiHs.645328.

Genome annotation databases

EnsembliENST00000285805; ENSP00000285805; ENSG00000155428.
ENST00000395244; ENSP00000378665; ENSG00000155428. [Q86UV6-2]
GeneIDi378108.
KEGGihsa:378108.
UCSCiuc003tws.1. human. [Q86UV6-2]
uc022afm.1. human. [Q86UV6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498999 mRNA. Translation: AAP30736.1.
AC005488 Genomic DNA. No translation available.
BC033871 mRNA. Translation: AAH33871.1.
CCDSiCCDS5545.1. [Q86UV6-1]
RefSeqiNP_942150.1. NM_198853.1. [Q86UV6-1]
XP_006716043.1. XM_006715980.2. [Q86UV6-2]
XP_011514489.1. XM_011516187.1. [Q86UV6-1]
XP_011514490.1. XM_011516188.1. [Q86UV6-1]
XP_011514491.1. XM_011516189.1. [Q86UV6-2]
UniGeneiHs.645328.

3D structure databases

ProteinModelPortaliQ86UV6.
SMRiQ86UV6. Positions 10-59, 89-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132031. 13 interactions.
IntActiQ86UV6. 9 interactions.
STRINGi9606.ENSP00000285805.

Polymorphism and mutation databases

BioMutaiTRIM74.
DMDMi56404879.

Proteomic databases

PRIDEiQ86UV6.

Protocols and materials databases

DNASUi378108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285805; ENSP00000285805; ENSG00000155428.
ENST00000395244; ENSP00000378665; ENSG00000155428. [Q86UV6-2]
GeneIDi378108.
KEGGihsa:378108.
UCSCiuc003tws.1. human. [Q86UV6-2]
uc022afm.1. human. [Q86UV6-1]

Organism-specific databases

CTDi378108.
GeneCardsiGC07M072430.
HGNCiHGNC:17453. TRIM74.
MIMi612550. gene.
neXtProtiNX_Q86UV6.
PharmGKBiPA38454.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118838.
HOGENOMiHOG000081784.
HOVERGENiHBG094091.
InParanoidiQ86UV6.
KOiK12024.
OMAiCHRDAEL.
OrthoDBiEOG74R1QB.
PhylomeDBiQ86UV6.
TreeFamiTF342569.

Miscellaneous databases

GenomeRNAii378108.
NextBioi100709.
PROiQ86UV6.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UV6.
CleanExiHS_TRIM74.
GenevisibleiQ86UV6. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-13.
    Tissue: Lung.

Entry informationi

Entry nameiTRI74_HUMAN
AccessioniPrimary (citable) accession number: Q86UV6
Secondary accession number(s): B7WP46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.