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Q86UV6

- TRI74_HUMAN

UniProt

Q86UV6 - TRI74_HUMAN

Protein

Tripartite motif-containing protein 74

Gene

TRIM74

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 5742RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri84 – 12542B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 74
    Alternative name(s):
    Tripartite motif-containing protein 50C
    Gene namesi
    Name:TRIM74
    Synonyms:TRIM50C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:17453. TRIM74.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38454.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Tripartite motif-containing protein 74PRO_0000056279Add
    BLAST

    Proteomic databases

    PRIDEiQ86UV6.

    Expressioni

    Gene expression databases

    BgeeiQ86UV6.
    CleanExiHS_TRIM74.
    GenevestigatoriQ86UV6.

    Interactioni

    Protein-protein interaction databases

    BioGridi132031. 11 interactions.
    IntActiQ86UV6. 8 interactions.
    STRINGi9606.ENSP00000285805.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UV6.
    SMRiQ86UV6. Positions 10-59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili125 – 16945Sequence AnalysisAdd
    BLAST
    Coiled coili204 – 23532Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 5742RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri84 – 12542B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    HOGENOMiHOG000081784.
    HOVERGENiHBG094091.
    InParanoidiQ86UV6.
    KOiK12024.
    OrthoDBiEOG74R1QB.
    PhylomeDBiQ86UV6.
    TreeFamiTF342569.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR000315. Znf_B-box.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00643. zf-B_box. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view]
    SMARTiSM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86UV6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAWQVSLLEL EDWLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK    50
    VRCPMCWQVV DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC 100
    EKDQELICGL CGLLGSHQHH PVTPVSTVCS RMKEELAALF SELKQEQKKV 150
    DELIAKLVKN RTRIVNESDV FSWVIRREFQ ELRHPVDEEK ARCLEGIGGH 200
    TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF IWKFHSMASR 250
    Length:250
    Mass (Da):28,547
    Last modified:June 1, 2003 - v1
    Checksum:i6B2F10940B04AC2B
    GO
    Isoform 2 (identifier: Q86UV6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         243-243: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:249
    Mass (Da):28,419
    Checksum:i5EB8FF5830F401E7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti128 – 1281V → I in AAH33871. (PubMed:15489334)Curated
    Sequence conflicti159 – 1591K → N in AAH33871. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131W → R.1 Publication
    Corresponds to variant rs121966 [ dbSNP | Ensembl ].
    VAR_039576

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei243 – 2431Missing in isoform 2. 1 PublicationVSP_032087

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF498999 mRNA. Translation: AAP30736.1.
    AC005488 Genomic DNA. No translation available.
    BC033871 mRNA. Translation: AAH33871.1.
    CCDSiCCDS5545.1. [Q86UV6-1]
    RefSeqiNP_942150.1. NM_198853.1. [Q86UV6-1]
    XP_006716043.1. XM_006715980.1. [Q86UV6-2]
    UniGeneiHs.645328.

    Genome annotation databases

    EnsembliENST00000285805; ENSP00000285805; ENSG00000155428. [Q86UV6-1]
    ENST00000395244; ENSP00000378665; ENSG00000155428. [Q86UV6-2]
    GeneIDi378108.
    KEGGihsa:378108.
    UCSCiuc003tws.1. human. [Q86UV6-2]
    uc022afm.1. human. [Q86UV6-1]

    Polymorphism databases

    DMDMi56404879.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF498999 mRNA. Translation: AAP30736.1 .
    AC005488 Genomic DNA. No translation available.
    BC033871 mRNA. Translation: AAH33871.1 .
    CCDSi CCDS5545.1. [Q86UV6-1 ]
    RefSeqi NP_942150.1. NM_198853.1. [Q86UV6-1 ]
    XP_006716043.1. XM_006715980.1. [Q86UV6-2 ]
    UniGenei Hs.645328.

    3D structure databases

    ProteinModelPortali Q86UV6.
    SMRi Q86UV6. Positions 10-59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132031. 11 interactions.
    IntActi Q86UV6. 8 interactions.
    STRINGi 9606.ENSP00000285805.

    Polymorphism databases

    DMDMi 56404879.

    Proteomic databases

    PRIDEi Q86UV6.

    Protocols and materials databases

    DNASUi 378108.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285805 ; ENSP00000285805 ; ENSG00000155428 . [Q86UV6-1 ]
    ENST00000395244 ; ENSP00000378665 ; ENSG00000155428 . [Q86UV6-2 ]
    GeneIDi 378108.
    KEGGi hsa:378108.
    UCSCi uc003tws.1. human. [Q86UV6-2 ]
    uc022afm.1. human. [Q86UV6-1 ]

    Organism-specific databases

    CTDi 378108.
    GeneCardsi GC07M072430.
    HGNCi HGNC:17453. TRIM74.
    MIMi 612550. gene.
    neXtProti NX_Q86UV6.
    PharmGKBi PA38454.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000081784.
    HOVERGENi HBG094091.
    InParanoidi Q86UV6.
    KOi K12024.
    OrthoDBi EOG74R1QB.
    PhylomeDBi Q86UV6.
    TreeFami TF342569.

    Miscellaneous databases

    GenomeRNAii 378108.
    NextBioi 100709.
    PROi Q86UV6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86UV6.
    CleanExi HS_TRIM74.
    Genevestigatori Q86UV6.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR000315. Znf_B-box.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00643. zf-B_box. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view ]
    SMARTi SM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-13.
      Tissue: Lung.

    Entry informationi

    Entry nameiTRI74_HUMAN
    AccessioniPrimary (citable) accession number: Q86UV6
    Secondary accession number(s): B7WP46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3