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Q86UV6 (TRI74_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 74
Alternative name(s):
Tripartite motif-containing protein 50C
Gene names
Name:TRIM74
Synonyms:TRIM50C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86UV6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86UV6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     243-243: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Tripartite motif-containing protein 74
PRO_0000056279

Regions

Zinc finger16 – 5742RING-type
Zinc finger84 – 12542B box-type
Coiled coil125 – 16945 Potential
Coiled coil204 – 23532 Potential

Natural variations

Alternative sequence2431Missing in isoform 2.
VSP_032087
Natural variant131W → R. Ref.3
Corresponds to variant rs121966 [ dbSNP | Ensembl ].
VAR_039576

Experimental info

Sequence conflict1281V → I in AAH33871. Ref.3
Sequence conflict1591K → N in AAH33871. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 6B2F10940B04AC2B

FASTA25028,547
        10         20         30         40         50         60 
MAWQVSLLEL EDWLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK VRCPMCWQVV 

        70         80         90        100        110        120 
DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH 

       130        140        150        160        170        180 
PVTPVSTVCS RMKEELAALF SELKQEQKKV DELIAKLVKN RTRIVNESDV FSWVIRREFQ 

       190        200        210        220        230        240 
ELRHPVDEEK ARCLEGIGGH TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF 

       250 
IWKFHSMASR 

« Hide

Isoform 2 [UniParc].

Checksum: 5EB8FF5830F401E7
Show »

FASTA24928,419

References

« Hide 'large scale' references
[1]"Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase."
Micale L., Fusco C., Augello B., Napolitano L.M.R., Dermitzakis E.T., Meroni G., Merla G., Reymond A.
Eur. J. Hum. Genet. 16:1038-1049(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-13.
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF498999 mRNA. Translation: AAP30736.1.
AC005488 Genomic DNA. No translation available.
BC033871 mRNA. Translation: AAH33871.1.
CCDSCCDS5545.1. [Q86UV6-1]
RefSeqNP_942150.1. NM_198853.1. [Q86UV6-1]
XP_006716043.1. XM_006715980.1. [Q86UV6-2]
UniGeneHs.645328.

3D structure databases

ProteinModelPortalQ86UV6.
SMRQ86UV6. Positions 10-59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid132031. 11 interactions.
IntActQ86UV6. 8 interactions.
STRING9606.ENSP00000285805.

Polymorphism databases

DMDM56404879.

Proteomic databases

PRIDEQ86UV6.

Protocols and materials databases

DNASU378108.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000285805; ENSP00000285805; ENSG00000155428. [Q86UV6-1]
ENST00000395244; ENSP00000378665; ENSG00000155428. [Q86UV6-2]
ENST00000571453; ENSP00000458771; ENSG00000262421. [Q86UV6-2]
ENST00000573986; ENSP00000458390; ENSG00000262421. [Q86UV6-1]
GeneID378108.
KEGGhsa:378108.
UCSCuc003tws.1. human. [Q86UV6-2]
uc022afm.1. human. [Q86UV6-1]

Organism-specific databases

CTD378108.
GeneCardsGC07M072430.
HGNCHGNC:17453. TRIM74.
MIM612550. gene.
neXtProtNX_Q86UV6.
PharmGKBPA38454.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000081784.
HOVERGENHBG094091.
InParanoidQ86UV6.
KOK12024.
OrthoDBEOG74R1QB.
PhylomeDBQ86UV6.
TreeFamTF342569.

Gene expression databases

BgeeQ86UV6.
CleanExHS_TRIM74.
GenevestigatorQ86UV6.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi378108.
NextBio100709.
PROQ86UV6.
SOURCESearch...

Entry information

Entry nameTRI74_HUMAN
AccessionPrimary (citable) accession number: Q86UV6
Secondary accession number(s): B7WP46
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM