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Q86UV5

- UBP48_HUMAN

UniProt

Q86UV5 - UBP48_HUMAN

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Protein

Ubiquitin carboxyl-terminal hydrolase 48

Gene

USP48

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981NucleophilePROSITE-ProRule annotation
Active sitei353 – 3531Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.068.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 48
Ubiquitin thioesterase 48
Ubiquitin-specific-processing protease 48
Gene namesi
Name:USP48
Synonyms:USP31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18533. USP48.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. mitochondrion Source: HPA
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134947522.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10351035Ubiquitin carboxyl-terminal hydrolase 48PRO_0000249523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei886 – 8861Phosphoserine2 Publications
Modified residuei887 – 8871Phosphoserine1 Publication
Modified residuei888 – 8881Phosphoserine2 Publications
Modified residuei956 – 9561N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ86UV5.
PaxDbiQ86UV5.
PRIDEiQ86UV5.

PTM databases

PhosphoSiteiQ86UV5.

Expressioni

Tissue specificityi

Widely expressed.3 Publications

Gene expression databases

BgeeiQ86UV5.
CleanExiHS_USP31.
HS_USP48.
ExpressionAtlasiQ86UV5. baseline and differential.
GenevestigatoriQ86UV5.

Organism-specific databases

HPAiHPA030045.
HPA030046.
HPA053976.

Interactioni

Subunit structurei

Interacts with TRAF2 and RELA.1 Publication

Protein-protein interaction databases

BioGridi123941. 14 interactions.
IntActiQ86UV5. 3 interactions.
MINTiMINT-7944238.

Structurei

3D structure databases

ProteinModelPortaliQ86UV5.
SMRiQ86UV5. Positions 84-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 421333USPAdd
BLAST
Domaini460 – 55495DUSP 1PROSITE-ProRule annotationAdd
BLAST
Domaini569 – 691123DUSP 2PROSITE-ProRule annotationAdd
BLAST
Domaini711 – 824114DUSP 3PROSITE-ProRule annotationAdd
BLAST
Domaini929 – 100981Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 DUSP domains.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00760000119158.
HOVERGENiHBG080368.
InParanoidiQ86UV5.
KOiK11858.
OrthoDBiEOG72G16G.
PhylomeDBiQ86UV5.
TreeFamiTF106280.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86UV5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCKG
60 70 80 90 100
NPNCLVGIGE HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV
110 120 130 140 150
NTFLQVWFLN LELRQALYLC PSTCSDYMLG DGIQEEKDYE PQTICEHLQY
160 170 180 190 200
LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ DAQEFSKLFM SLLEDTLSKQ
210 220 230 240 250
KNPDVRNIVQ QQFCGEYAYV TVCNQCGRES KLLSKFYELE LNIQGHKQLT
260 270 280 290 300
DCISEFLKEE KLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV
310 320 330 340 350
FDRQTGHKKK LNTYIGFSEI LDMEPYVEHK GGSYVYELSA VLIHRGVSAY
360 370 380 390 400
SGHYIAHVKD PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL AEPSKSQTRK
410 420 430 440 450
PKCGKGTHCS RNAYMLVYRL QTQEKPNTTV QVPAFLQELV DRDNSKFEEW
460 470 480 490 500
CIEMAEMRKQ SVDKGKAKHE EVKELYQRLP AGAEPYEFVS LEWLQKWLDE
510 520 530 540 550
STPTKPIDNH ACLCSHDKLH PDKISIMKRI SEYAADIFYS RYGGGPRLTV
560 570 580 590 600
KALCKECVVE RCRILRLKNQ LNEDYKTVNN LLKAAVKGSD GFWVGKSSLR
610 620 630 640 650
SWRQLALEQL DEQDGDAEQS NGKMNGSTLN KDESKEERKE EEELNFNEDI
660 670 680 690 700
LCPHGELCIS ENERRLVSKE AWSKLQQYFP KAPEFPSYKE CCSQCKILER
710 720 730 740 750
EGEENEALHK MIANEQKTSL PNLFQDKNRP CLSNWPEDTD VLYIVSQFFV
760 770 780 790 800
EEWRKFVRKP TRCSPVSSVG NSALLCPHGG LMFTFASMTK EDSKLIALIW
810 820 830 840 850
PSEWQMIQKL FVVDHVIKIT RIEVGDVNPS ETQYISEPKL CPECREGLLC
860 870 880 890 900
QQQRDLREYT QATIYVHKVV DNKKVMKDSA PELNVSSSET EEDKEEAKPD
910 920 930 940 950
GEKDPDFNQS NGGTKRQKIS HQNYIAYQKQ VIRRSMRHRK VRGEKALLVS
960 970 980 990 1000
ANQTLKELKI QIMHAFSVAP FDQNLSIDGK ILSDDCATLG TLGVIPESVI
1010 1020 1030
LLKADEPIAD YAAMDDVMQV CMPEEGFKGT GLLGH
Length:1,035
Mass (Da):119,032
Last modified:June 1, 2003 - v1
Checksum:i6F7DAF88527E2627
GO
Isoform 2 (identifier: Q86UV5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     909-960: Missing.

Note: No experimental confirmation available.

Show »
Length:983
Mass (Da):112,959
Checksum:iB19F5EC40029858F
GO
Isoform 3 (identifier: Q86UV5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     704-1035: Missing.

Note: No experimental confirmation available.

Show »
Length:703
Mass (Da):81,449
Checksum:iA7608F78005CF98D
GO
Isoform 4 (identifier: Q86UV5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-392: FNDEDIEKMEGKKLQLGIEEDLAE → LILNTNYHLPPSPKPIKIKNYNKP
     393-1035: Missing.

Note: No experimental confirmation available.

Show »
Length:392
Mass (Da):45,481
Checksum:i675B208E4EFA5350
GO
Isoform 5 (identifier: Q86UV5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.
     470-483: EEVKELYQRLPAGA → MNLSLSQKTVKIHRLFPMLAFS
     589-589: Missing.
     909-960: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:521
Mass (Da):59,454
Checksum:i20D3FA1221CF6383
GO
Isoform 6 (identifier: Q86UV5-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-875: Missing.
     1020-1035: VCMPEEGFKGTGLLGH → GKDEFVLGIC

Note: No experimental confirmation available.

Show »
Length:154
Mass (Da):17,094
Checksum:iC8309D66B49A9AF6
GO
Isoform 7 (identifier: Q86UV5-7) [UniParc]FASTAAdd to Basket

Also known as: USP31S1

The sequence of this isoform differs from the canonical sequence as follows:
     484-485: EP → GL
     486-1035: Missing.

Show »
Length:485
Mass (Da):56,151
Checksum:iE519B70ABF229820
GO
Isoform 8 (identifier: Q86UV5-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-391: Missing.
     654-654: H → HAVFFFSKYIFLNS

Note: No experimental confirmation available.

Show »
Length:1,047
Mass (Da):120,526
Checksum:i6DD9F285164E7ADD
GO

Sequence cautioni

The sequence AAH67261.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAI03725.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
Isoform 5 : The sequence BAB15533.1 differs from that shown. Reason: Frameshift at position 109.
The sequence AAH13567.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA92128.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI12124.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI16260.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251S → C.
Corresponds to variant rs4253886 [ dbSNP | Ensembl ].
VAR_027427
Natural varianti135 – 1351E → K.
Corresponds to variant rs12097805 [ dbSNP | Ensembl ].
VAR_027428

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 875875Missing in isoform 6. 1 PublicationVSP_020471Add
BLAST
Alternative sequencei1 – 469469Missing in isoform 5. 1 PublicationVSP_020472Add
BLAST
Alternative sequencei369 – 39224FNDED…EDLAE → LILNTNYHLPPSPKPIKIKN YNKP in isoform 4. 1 PublicationVSP_020473Add
BLAST
Alternative sequencei391 – 3911Missing in isoform 8. 1 PublicationVSP_054487
Alternative sequencei393 – 1035643Missing in isoform 4. 1 PublicationVSP_020474Add
BLAST
Alternative sequencei470 – 48314EEVKE…LPAGA → MNLSLSQKTVKIHRLFPMLA FS in isoform 5. 1 PublicationVSP_020475Add
BLAST
Alternative sequencei484 – 4852EP → GL in isoform 7. CuratedVSP_020476
Alternative sequencei486 – 1035550Missing in isoform 7. CuratedVSP_020477Add
BLAST
Alternative sequencei589 – 5891Missing in isoform 5. 1 PublicationVSP_020478
Alternative sequencei654 – 6541H → HAVFFFSKYIFLNS in isoform 8. 1 PublicationVSP_054488
Alternative sequencei704 – 1035332Missing in isoform 3. 1 PublicationVSP_020479Add
BLAST
Alternative sequencei909 – 96052Missing in isoform 2 and isoform 5. 2 PublicationsVSP_020480Add
BLAST
Alternative sequencei1020 – 103516VCMPE…GLLGH → GKDEFVLGIC in isoform 6. 1 PublicationVSP_020481Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF502942 mRNA. Translation: AAP30832.1.
AL590103 Genomic DNA. Translation: CAI12124.1. Sequence problems.
AL590103, AL359815 Genomic DNA. Translation: CAI12127.1.
AL359815, AL590103 Genomic DNA. Translation: CAI16256.1.
AL359815 Genomic DNA. Translation: CAI16260.1. Sequence problems.
AK000110 mRNA. Translation: BAA90950.1.
AK002190 mRNA. Translation: BAA92128.1. Different initiation.
AK026707 mRNA. Translation: BAB15533.1. Frameshift.
AK026930 mRNA. Translation: BAB15591.1.
BC007326 mRNA. Translation: AAH07326.2.
BC013567 mRNA. Translation: AAH13567.1. Different initiation.
BC067261 mRNA. Translation: AAH67261.1. Sequence problems.
BC103724 mRNA. Translation: AAI03725.1. Sequence problems.
BC104896 mRNA. Translation: AAI04897.1.
BC143354 mRNA. Translation: AAI43355.1.
AL834375 mRNA. Translation: CAD39038.1.
CCDSiCCDS30623.1. [Q86UV5-1]
CCDS44084.1. [Q86UV5-7]
RefSeqiNP_001027902.1. NM_001032730.1. [Q86UV5-7]
NP_115612.4. NM_032236.5. [Q86UV5-1]
XP_005246066.1. XM_005246009.1. [Q86UV5-2]
UniGeneiHs.467524.

Genome annotation databases

EnsembliENST00000308271; ENSP00000309262; ENSG00000090686. [Q86UV5-1]
ENST00000400301; ENSP00000383157; ENSG00000090686. [Q86UV5-2]
ENST00000421625; ENSP00000406256; ENSG00000090686. [Q86UV5-7]
ENST00000529637; ENSP00000431949; ENSG00000090686. [Q86UV5-8]
GeneIDi84196.
KEGGihsa:84196.
UCSCiuc001bfa.3. human. [Q86UV5-5]
uc001bfb.3. human. [Q86UV5-1]
uc001bfc.3. human. [Q86UV5-2]
uc001bfd.1. human. [Q86UV5-6]
uc001bfe.1. human.
uc001bff.3. human. [Q86UV5-7]

Polymorphism databases

DMDMi74750436.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF502942 mRNA. Translation: AAP30832.1 .
AL590103 Genomic DNA. Translation: CAI12124.1 . Sequence problems.
AL590103 , AL359815 Genomic DNA. Translation: CAI12127.1 .
AL359815 , AL590103 Genomic DNA. Translation: CAI16256.1 .
AL359815 Genomic DNA. Translation: CAI16260.1 . Sequence problems.
AK000110 mRNA. Translation: BAA90950.1 .
AK002190 mRNA. Translation: BAA92128.1 . Different initiation.
AK026707 mRNA. Translation: BAB15533.1 . Frameshift.
AK026930 mRNA. Translation: BAB15591.1 .
BC007326 mRNA. Translation: AAH07326.2 .
BC013567 mRNA. Translation: AAH13567.1 . Different initiation.
BC067261 mRNA. Translation: AAH67261.1 . Sequence problems.
BC103724 mRNA. Translation: AAI03725.1 . Sequence problems.
BC104896 mRNA. Translation: AAI04897.1 .
BC143354 mRNA. Translation: AAI43355.1 .
AL834375 mRNA. Translation: CAD39038.1 .
CCDSi CCDS30623.1. [Q86UV5-1 ]
CCDS44084.1. [Q86UV5-7 ]
RefSeqi NP_001027902.1. NM_001032730.1. [Q86UV5-7 ]
NP_115612.4. NM_032236.5. [Q86UV5-1 ]
XP_005246066.1. XM_005246009.1. [Q86UV5-2 ]
UniGenei Hs.467524.

3D structure databases

ProteinModelPortali Q86UV5.
SMRi Q86UV5. Positions 84-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123941. 14 interactions.
IntActi Q86UV5. 3 interactions.
MINTi MINT-7944238.

Protein family/group databases

MEROPSi C19.068.

PTM databases

PhosphoSitei Q86UV5.

Polymorphism databases

DMDMi 74750436.

Proteomic databases

MaxQBi Q86UV5.
PaxDbi Q86UV5.
PRIDEi Q86UV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308271 ; ENSP00000309262 ; ENSG00000090686 . [Q86UV5-1 ]
ENST00000400301 ; ENSP00000383157 ; ENSG00000090686 . [Q86UV5-2 ]
ENST00000421625 ; ENSP00000406256 ; ENSG00000090686 . [Q86UV5-7 ]
ENST00000529637 ; ENSP00000431949 ; ENSG00000090686 . [Q86UV5-8 ]
GeneIDi 84196.
KEGGi hsa:84196.
UCSCi uc001bfa.3. human. [Q86UV5-5 ]
uc001bfb.3. human. [Q86UV5-1 ]
uc001bfc.3. human. [Q86UV5-2 ]
uc001bfd.1. human. [Q86UV5-6 ]
uc001bfe.1. human.
uc001bff.3. human. [Q86UV5-7 ]

Organism-specific databases

CTDi 84196.
GeneCardsi GC01M022004.
HGNCi HGNC:18533. USP48.
HPAi HPA030045.
HPA030046.
HPA053976.
neXtProti NX_Q86UV5.
PharmGKBi PA134947522.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00760000119158.
HOVERGENi HBG080368.
InParanoidi Q86UV5.
KOi K11858.
OrthoDBi EOG72G16G.
PhylomeDBi Q86UV5.
TreeFami TF106280.

Miscellaneous databases

ChiTaRSi USP48. human.
GeneWikii USP48.
GenomeRNAii 84196.
NextBioi 35481187.
PROi Q86UV5.

Gene expression databases

Bgeei Q86UV5.
CleanExi HS_USP31.
HS_USP48.
ExpressionAtlasi Q86UV5. baseline and differential.
Genevestigatori Q86UV5.

Family and domain databases

Gene3Di 3.30.2230.10. 1 hit.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis."
    Lockhart P.J., Hulihan M., Lincoln S., Hussey J., Skipper L., Bisceglio G., Wilkes K., Farrer M.J.
    DNA Seq. 15:9-14(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 712-1035 (ISOFORM 1).
    Tissue: Colon, Hepatoma and Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 399-1035 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-636 (ISOFORMS 1/2).
    Tissue: Colon, Eye, Pancreas, Skin and Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 691-1035 (ISOFORM 1).
    Tissue: Melanoma.
  6. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
    Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
    Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB."
    Tzimas C., Michailidou G., Arsenakis M., Kieff E., Mosialos G., Hatzivassiliou E.G.
    Cell. Signal. 18:83-92(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 7), ENZYME ACTIVITY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH RELA AND TRAF2.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-956, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886; SER-887 AND SER-888, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886 AND SER-888, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBP48_HUMAN
AccessioniPrimary (citable) accession number: Q86UV5
Secondary accession number(s): B7ZKS7
, Q2M3I4, Q5SZI4, Q5T3T5, Q6NX53, Q8N3F6, Q96F64, Q96IQ3, Q9H5N3, Q9H5T7, Q9NUJ6, Q9NXR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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