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Q86UV5

- UBP48_HUMAN

UniProt

Q86UV5 - UBP48_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase 48

Gene

USP48

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981NucleophilePROSITE-ProRule annotation
    Active sitei353 – 3531Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.068.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 48
    Ubiquitin thioesterase 48
    Ubiquitin-specific-processing protease 48
    Gene namesi
    Name:USP48
    Synonyms:USP31
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18533. USP48.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. mitochondrion Source: HPA
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134947522.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10351035Ubiquitin carboxyl-terminal hydrolase 48PRO_0000249523Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei886 – 8861Phosphoserine2 Publications
    Modified residuei887 – 8871Phosphoserine1 Publication
    Modified residuei888 – 8881Phosphoserine2 Publications
    Modified residuei956 – 9561N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ86UV5.
    PaxDbiQ86UV5.
    PRIDEiQ86UV5.

    PTM databases

    PhosphoSiteiQ86UV5.

    Expressioni

    Tissue specificityi

    Widely expressed.3 Publications

    Gene expression databases

    ArrayExpressiQ86UV5.
    BgeeiQ86UV5.
    CleanExiHS_USP31.
    HS_USP48.
    GenevestigatoriQ86UV5.

    Organism-specific databases

    HPAiHPA030045.
    HPA030046.
    HPA053976.

    Interactioni

    Subunit structurei

    Interacts with TRAF2 and RELA.1 Publication

    Protein-protein interaction databases

    BioGridi123941. 13 interactions.
    IntActiQ86UV5. 3 interactions.
    MINTiMINT-7944238.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UV5.
    SMRiQ86UV5. Positions 84-442, 945-996.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini89 – 421333USPAdd
    BLAST
    Domaini460 – 55495DUSP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini569 – 691123DUSP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini711 – 824114DUSP 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini929 – 100981Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 3 DUSP domains.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5077.
    HOVERGENiHBG080368.
    InParanoidiQ86UV5.
    KOiK11858.
    OrthoDBiEOG72G16G.
    PhylomeDBiQ86UV5.
    TreeFamiTF106280.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86UV5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCKG     50
    NPNCLVGIGE HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV 100
    NTFLQVWFLN LELRQALYLC PSTCSDYMLG DGIQEEKDYE PQTICEHLQY 150
    LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ DAQEFSKLFM SLLEDTLSKQ 200
    KNPDVRNIVQ QQFCGEYAYV TVCNQCGRES KLLSKFYELE LNIQGHKQLT 250
    DCISEFLKEE KLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV 300
    FDRQTGHKKK LNTYIGFSEI LDMEPYVEHK GGSYVYELSA VLIHRGVSAY 350
    SGHYIAHVKD PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL AEPSKSQTRK 400
    PKCGKGTHCS RNAYMLVYRL QTQEKPNTTV QVPAFLQELV DRDNSKFEEW 450
    CIEMAEMRKQ SVDKGKAKHE EVKELYQRLP AGAEPYEFVS LEWLQKWLDE 500
    STPTKPIDNH ACLCSHDKLH PDKISIMKRI SEYAADIFYS RYGGGPRLTV 550
    KALCKECVVE RCRILRLKNQ LNEDYKTVNN LLKAAVKGSD GFWVGKSSLR 600
    SWRQLALEQL DEQDGDAEQS NGKMNGSTLN KDESKEERKE EEELNFNEDI 650
    LCPHGELCIS ENERRLVSKE AWSKLQQYFP KAPEFPSYKE CCSQCKILER 700
    EGEENEALHK MIANEQKTSL PNLFQDKNRP CLSNWPEDTD VLYIVSQFFV 750
    EEWRKFVRKP TRCSPVSSVG NSALLCPHGG LMFTFASMTK EDSKLIALIW 800
    PSEWQMIQKL FVVDHVIKIT RIEVGDVNPS ETQYISEPKL CPECREGLLC 850
    QQQRDLREYT QATIYVHKVV DNKKVMKDSA PELNVSSSET EEDKEEAKPD 900
    GEKDPDFNQS NGGTKRQKIS HQNYIAYQKQ VIRRSMRHRK VRGEKALLVS 950
    ANQTLKELKI QIMHAFSVAP FDQNLSIDGK ILSDDCATLG TLGVIPESVI 1000
    LLKADEPIAD YAAMDDVMQV CMPEEGFKGT GLLGH 1035
    Length:1,035
    Mass (Da):119,032
    Last modified:June 1, 2003 - v1
    Checksum:i6F7DAF88527E2627
    GO
    Isoform 2 (identifier: Q86UV5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         909-960: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:983
    Mass (Da):112,959
    Checksum:iB19F5EC40029858F
    GO
    Isoform 3 (identifier: Q86UV5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         704-1035: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:703
    Mass (Da):81,449
    Checksum:iA7608F78005CF98D
    GO
    Isoform 4 (identifier: Q86UV5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         369-392: FNDEDIEKMEGKKLQLGIEEDLAE → LILNTNYHLPPSPKPIKIKNYNKP
         393-1035: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:392
    Mass (Da):45,481
    Checksum:i675B208E4EFA5350
    GO
    Isoform 5 (identifier: Q86UV5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-469: Missing.
         470-483: EEVKELYQRLPAGA → MNLSLSQKTVKIHRLFPMLAFS
         589-589: Missing.
         909-960: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:521
    Mass (Da):59,454
    Checksum:i20D3FA1221CF6383
    GO
    Isoform 6 (identifier: Q86UV5-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-875: Missing.
         1020-1035: VCMPEEGFKGTGLLGH → GKDEFVLGIC

    Note: No experimental confirmation available.

    Show »
    Length:154
    Mass (Da):17,094
    Checksum:iC8309D66B49A9AF6
    GO
    Isoform 7 (identifier: Q86UV5-7) [UniParc]FASTAAdd to Basket

    Also known as: USP31S1

    The sequence of this isoform differs from the canonical sequence as follows:
         484-485: EP → GL
         486-1035: Missing.

    Show »
    Length:485
    Mass (Da):56,151
    Checksum:iE519B70ABF229820
    GO
    Isoform 8 (identifier: Q86UV5-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         391-391: Missing.
         654-654: H → HAVFFFSKYIFLNS

    Note: No experimental confirmation available.

    Show »
    Length:1,047
    Mass (Da):120,526
    Checksum:i6DD9F285164E7ADD
    GO

    Sequence cautioni

    The sequence AAH67261.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAI03725.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    Isoform 5 : The sequence BAB15533.1 differs from that shown. Reason: Frameshift at position 109.
    The sequence AAH13567.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA92128.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI12124.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI16260.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti125 – 1251S → C.
    Corresponds to variant rs4253886 [ dbSNP | Ensembl ].
    VAR_027427
    Natural varianti135 – 1351E → K.
    Corresponds to variant rs12097805 [ dbSNP | Ensembl ].
    VAR_027428

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 875875Missing in isoform 6. 1 PublicationVSP_020471Add
    BLAST
    Alternative sequencei1 – 469469Missing in isoform 5. 1 PublicationVSP_020472Add
    BLAST
    Alternative sequencei369 – 39224FNDED…EDLAE → LILNTNYHLPPSPKPIKIKN YNKP in isoform 4. 1 PublicationVSP_020473Add
    BLAST
    Alternative sequencei391 – 3911Missing in isoform 8. 1 PublicationVSP_054487
    Alternative sequencei393 – 1035643Missing in isoform 4. 1 PublicationVSP_020474Add
    BLAST
    Alternative sequencei470 – 48314EEVKE…LPAGA → MNLSLSQKTVKIHRLFPMLA FS in isoform 5. 1 PublicationVSP_020475Add
    BLAST
    Alternative sequencei484 – 4852EP → GL in isoform 7. CuratedVSP_020476
    Alternative sequencei486 – 1035550Missing in isoform 7. CuratedVSP_020477Add
    BLAST
    Alternative sequencei589 – 5891Missing in isoform 5. 1 PublicationVSP_020478
    Alternative sequencei654 – 6541H → HAVFFFSKYIFLNS in isoform 8. 1 PublicationVSP_054488
    Alternative sequencei704 – 1035332Missing in isoform 3. 1 PublicationVSP_020479Add
    BLAST
    Alternative sequencei909 – 96052Missing in isoform 2 and isoform 5. 2 PublicationsVSP_020480Add
    BLAST
    Alternative sequencei1020 – 103516VCMPE…GLLGH → GKDEFVLGIC in isoform 6. 1 PublicationVSP_020481Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF502942 mRNA. Translation: AAP30832.1.
    AL590103 Genomic DNA. Translation: CAI12124.1. Sequence problems.
    AL590103, AL359815 Genomic DNA. Translation: CAI12127.1.
    AL359815, AL590103 Genomic DNA. Translation: CAI16256.1.
    AL359815 Genomic DNA. Translation: CAI16260.1. Sequence problems.
    AK000110 mRNA. Translation: BAA90950.1.
    AK002190 mRNA. Translation: BAA92128.1. Different initiation.
    AK026707 mRNA. Translation: BAB15533.1. Frameshift.
    AK026930 mRNA. Translation: BAB15591.1.
    BC007326 mRNA. Translation: AAH07326.2.
    BC013567 mRNA. Translation: AAH13567.1. Different initiation.
    BC067261 mRNA. Translation: AAH67261.1. Sequence problems.
    BC103724 mRNA. Translation: AAI03725.1. Sequence problems.
    BC104896 mRNA. Translation: AAI04897.1.
    BC143354 mRNA. Translation: AAI43355.1.
    AL834375 mRNA. Translation: CAD39038.1.
    CCDSiCCDS30623.1. [Q86UV5-1]
    CCDS44084.1. [Q86UV5-7]
    RefSeqiNP_001027902.1. NM_001032730.1. [Q86UV5-7]
    NP_115612.4. NM_032236.5. [Q86UV5-1]
    XP_005246066.1. XM_005246009.1. [Q86UV5-2]
    UniGeneiHs.467524.

    Genome annotation databases

    EnsembliENST00000308271; ENSP00000309262; ENSG00000090686. [Q86UV5-1]
    ENST00000400301; ENSP00000383157; ENSG00000090686. [Q86UV5-2]
    ENST00000421625; ENSP00000406256; ENSG00000090686. [Q86UV5-7]
    ENST00000529637; ENSP00000431949; ENSG00000090686. [Q86UV5-8]
    GeneIDi84196.
    KEGGihsa:84196.
    UCSCiuc001bfa.3. human. [Q86UV5-5]
    uc001bfb.3. human. [Q86UV5-1]
    uc001bfc.3. human. [Q86UV5-2]
    uc001bfd.1. human. [Q86UV5-6]
    uc001bff.3. human. [Q86UV5-7]

    Polymorphism databases

    DMDMi74750436.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF502942 mRNA. Translation: AAP30832.1 .
    AL590103 Genomic DNA. Translation: CAI12124.1 . Sequence problems.
    AL590103 , AL359815 Genomic DNA. Translation: CAI12127.1 .
    AL359815 , AL590103 Genomic DNA. Translation: CAI16256.1 .
    AL359815 Genomic DNA. Translation: CAI16260.1 . Sequence problems.
    AK000110 mRNA. Translation: BAA90950.1 .
    AK002190 mRNA. Translation: BAA92128.1 . Different initiation.
    AK026707 mRNA. Translation: BAB15533.1 . Frameshift.
    AK026930 mRNA. Translation: BAB15591.1 .
    BC007326 mRNA. Translation: AAH07326.2 .
    BC013567 mRNA. Translation: AAH13567.1 . Different initiation.
    BC067261 mRNA. Translation: AAH67261.1 . Sequence problems.
    BC103724 mRNA. Translation: AAI03725.1 . Sequence problems.
    BC104896 mRNA. Translation: AAI04897.1 .
    BC143354 mRNA. Translation: AAI43355.1 .
    AL834375 mRNA. Translation: CAD39038.1 .
    CCDSi CCDS30623.1. [Q86UV5-1 ]
    CCDS44084.1. [Q86UV5-7 ]
    RefSeqi NP_001027902.1. NM_001032730.1. [Q86UV5-7 ]
    NP_115612.4. NM_032236.5. [Q86UV5-1 ]
    XP_005246066.1. XM_005246009.1. [Q86UV5-2 ]
    UniGenei Hs.467524.

    3D structure databases

    ProteinModelPortali Q86UV5.
    SMRi Q86UV5. Positions 84-442, 945-996.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123941. 13 interactions.
    IntActi Q86UV5. 3 interactions.
    MINTi MINT-7944238.

    Protein family/group databases

    MEROPSi C19.068.

    PTM databases

    PhosphoSitei Q86UV5.

    Polymorphism databases

    DMDMi 74750436.

    Proteomic databases

    MaxQBi Q86UV5.
    PaxDbi Q86UV5.
    PRIDEi Q86UV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308271 ; ENSP00000309262 ; ENSG00000090686 . [Q86UV5-1 ]
    ENST00000400301 ; ENSP00000383157 ; ENSG00000090686 . [Q86UV5-2 ]
    ENST00000421625 ; ENSP00000406256 ; ENSG00000090686 . [Q86UV5-7 ]
    ENST00000529637 ; ENSP00000431949 ; ENSG00000090686 . [Q86UV5-8 ]
    GeneIDi 84196.
    KEGGi hsa:84196.
    UCSCi uc001bfa.3. human. [Q86UV5-5 ]
    uc001bfb.3. human. [Q86UV5-1 ]
    uc001bfc.3. human. [Q86UV5-2 ]
    uc001bfd.1. human. [Q86UV5-6 ]
    uc001bff.3. human. [Q86UV5-7 ]

    Organism-specific databases

    CTDi 84196.
    GeneCardsi GC01M022004.
    HGNCi HGNC:18533. USP48.
    HPAi HPA030045.
    HPA030046.
    HPA053976.
    neXtProti NX_Q86UV5.
    PharmGKBi PA134947522.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5077.
    HOVERGENi HBG080368.
    InParanoidi Q86UV5.
    KOi K11858.
    OrthoDBi EOG72G16G.
    PhylomeDBi Q86UV5.
    TreeFami TF106280.

    Miscellaneous databases

    ChiTaRSi USP48. human.
    GeneWikii USP48.
    GenomeRNAii 84196.
    NextBioi 35481187.
    PROi Q86UV5.

    Gene expression databases

    ArrayExpressi Q86UV5.
    Bgeei Q86UV5.
    CleanExi HS_USP31.
    HS_USP48.
    Genevestigatori Q86UV5.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis."
      Lockhart P.J., Hulihan M., Lincoln S., Hussey J., Skipper L., Bisceglio G., Wilkes K., Farrer M.J.
      DNA Seq. 15:9-14(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 712-1035 (ISOFORM 1).
      Tissue: Colon, Hepatoma and Placenta.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 399-1035 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-636 (ISOFORMS 1/2).
      Tissue: Colon, Eye, Pancreas, Skin and Uterus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 691-1035 (ISOFORM 1).
      Tissue: Melanoma.
    6. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
      Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
      Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB."
      Tzimas C., Michailidou G., Arsenakis M., Kieff E., Mosialos G., Hatzivassiliou E.G.
      Cell. Signal. 18:83-92(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 7), ENZYME ACTIVITY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH RELA AND TRAF2.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-956, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886; SER-887 AND SER-888, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886 AND SER-888, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUBP48_HUMAN
    AccessioniPrimary (citable) accession number: Q86UV5
    Secondary accession number(s): B7ZKS7
    , Q2M3I4, Q5SZI4, Q5T3T5, Q6NX53, Q8N3F6, Q96F64, Q96IQ3, Q9H5N3, Q9H5T7, Q9NUJ6, Q9NXR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3