Q86UV5 (UBP48_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 48
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 48
Ubiquitin thioesterase 48
Ubiquitin-specific-processing protease 48

Gene names

Name:	USP48
Synonyms:	USP31

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1035 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Ref.8
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Ref.8
Subunit structure	Interacts with TRAF2 and RELA. Ref.8
Subcellular location	Cytoplasm. Nucleus Ref.8.
Tissue specificity	Widely expressed. Ref.1 Ref.6 Ref.8
Sequence similarities	Belongs to the peptidase C19 family. Contains 3 DUSP domains. Contains 1 ubiquitin-like domain.
Caution	Was termed (Ref.1 and Ref.7) USP31.
Sequence caution	The sequence AAH13567.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH67261.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAI03725.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA92128.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI12124.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI16260.1 differs from that shown. Reason: Erroneous gene model prediction. Isoform 5: The sequence BAB15533.1 differs from that shown. Reason: Frameshift at position 109.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Molecular function	Hydrolase Protease Thiol protease
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86UV5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86UV5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     909-960: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q86UV5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     704-1035: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q86UV5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     369-392: FNDEDIEKMEGKKLQLGIEEDLAE → LILNTNYHLPPSPKPIKIKNYNKP
     393-1035: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q86UV5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.
     470-483: EEVKELYQRLPAGA → MNLSLSQKTVKIHRLFPMLAFS
     589-589: Missing.
     909-960: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q86UV5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-875: Missing.
     1020-1035: VCMPEEGFKGTGLLGH → GKDEFVLGIC

Note: No experimental confirmation available.

Isoform 7 (identifier: Q86UV5-7)

Also known as: USP31S1;

The sequence of this isoform differs from the canonical sequence as follows:
     484-485: EP → GL
     486-1035: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1035	1035	Ubiquitin carboxyl-terminal hydrolase 48		PRO_0000249523
Regions
	Domain	460 – 554	95	DUSP 1
	Domain	569 – 691	123	DUSP 2
	Domain	711 – 824	114	DUSP 3
	Domain	929 – 1009	81	Ubiquitin-like
Sites
	Active site	98	1	Nucleophile By similarity
	Active site	353	1	Proton acceptor By similarity
Amino acid modifications
	Modified residue	886	1	Phosphoserine Ref.10 Ref.12
	Modified residue	887	1	Phosphoserine Ref.10
	Modified residue	888	1	Phosphoserine Ref.10 Ref.12
	Modified residue	956	1	N6-acetyllysine Ref.9
Natural variations
	Alternative sequence	1 – 875	875	Missing in isoform 6.		VSP_020471
	Alternative sequence	1 – 469	469	Missing in isoform 5.		VSP_020472
	Alternative sequence	369 – 392	24	FNDED…EDLAE → LILNTNYHLPPSPKPIKIKN YNKP in isoform 4.		VSP_020473
	Alternative sequence	393 – 1035	643	Missing in isoform 4.		VSP_020474
	Alternative sequence	470 – 483	14	EEVKE…LPAGA → MNLSLSQKTVKIHRLFPMLA FS in isoform 5.		VSP_020475
	Alternative sequence	484 – 485	2	EP → GL in isoform 7.		VSP_020476
	Alternative sequence	486 – 1035	550	Missing in isoform 7.		VSP_020477
	Alternative sequence	589	1	Missing in isoform 5.		VSP_020478
	Alternative sequence	704 – 1035	332	Missing in isoform 3.		VSP_020479
	Alternative sequence	909 – 960	52	Missing in isoform 2 and isoform 5.		VSP_020480
	Alternative sequence	1020 – 1035	16	VCMPE…GLLGH → GKDEFVLGIC in isoform 6.		VSP_020481
	Natural variant	125	1	S → C. Corresponds to variant rs4253886 [ dbSNP | Ensembl ].		VAR_027427
	Natural variant	135	1	E → K. Corresponds to variant rs12097805 [ dbSNP | Ensembl ].		VAR_027428

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 6F7DAF88527E2627	FASTA	1,035	119,032
	10 20 30 40 50 60 MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCKG NPNCLVGIGE 70 80 90 100 110 120 HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV NTFLQVWFLN LELRQALYLC 130 140 150 160 170 180 PSTCSDYMLG DGIQEEKDYE PQTICEHLQY LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ 190 200 210 220 230 240 DAQEFSKLFM SLLEDTLSKQ KNPDVRNIVQ QQFCGEYAYV TVCNQCGRES KLLSKFYELE 250 260 270 280 290 300 LNIQGHKQLT DCISEFLKEE KLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV 310 320 330 340 350 360 FDRQTGHKKK LNTYIGFSEI LDMEPYVEHK GGSYVYELSA VLIHRGVSAY SGHYIAHVKD 370 380 390 400 410 420 PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL AEPSKSQTRK PKCGKGTHCS RNAYMLVYRL 430 440 450 460 470 480 QTQEKPNTTV QVPAFLQELV DRDNSKFEEW CIEMAEMRKQ SVDKGKAKHE EVKELYQRLP 490 500 510 520 530 540 AGAEPYEFVS LEWLQKWLDE STPTKPIDNH ACLCSHDKLH PDKISIMKRI SEYAADIFYS 550 560 570 580 590 600 RYGGGPRLTV KALCKECVVE RCRILRLKNQ LNEDYKTVNN LLKAAVKGSD GFWVGKSSLR 610 620 630 640 650 660 SWRQLALEQL DEQDGDAEQS NGKMNGSTLN KDESKEERKE EEELNFNEDI LCPHGELCIS 670 680 690 700 710 720 ENERRLVSKE AWSKLQQYFP KAPEFPSYKE CCSQCKILER EGEENEALHK MIANEQKTSL 730 740 750 760 770 780 PNLFQDKNRP CLSNWPEDTD VLYIVSQFFV EEWRKFVRKP TRCSPVSSVG NSALLCPHGG 790 800 810 820 830 840 LMFTFASMTK EDSKLIALIW PSEWQMIQKL FVVDHVIKIT RIEVGDVNPS ETQYISEPKL 850 860 870 880 890 900 CPECREGLLC QQQRDLREYT QATIYVHKVV DNKKVMKDSA PELNVSSSET EEDKEEAKPD 910 920 930 940 950 960 GEKDPDFNQS NGGTKRQKIS HQNYIAYQKQ VIRRSMRHRK VRGEKALLVS ANQTLKELKI 970 980 990 1000 1010 1020 QIMHAFSVAP FDQNLSIDGK ILSDDCATLG TLGVIPESVI LLKADEPIAD YAAMDDVMQV 1030 CMPEEGFKGT GLLGH
	Isoform 2 [UniParc]. Checksum: B19F5EC40029858F	FASTA	983	112,959
	10 20 30 40 50 60 MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCKG NPNCLVGIGE 70 80 90 100 110 120 HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV NTFLQVWFLN LELRQALYLC 130 140 150 160 170 180 PSTCSDYMLG DGIQEEKDYE PQTICEHLQY LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ 190 200 210 220 230 240 DAQEFSKLFM SLLEDTLSKQ KNPDVRNIVQ QQFCGEYAYV TVCNQCGRES KLLSKFYELE 250 260 270 280 290 300 LNIQGHKQLT DCISEFLKEE KLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV 310 320 330 340 350 360 FDRQTGHKKK LNTYIGFSEI LDMEPYVEHK GGSYVYELSA VLIHRGVSAY SGHYIAHVKD 370 380 390 400 410 420 PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL AEPSKSQTRK PKCGKGTHCS RNAYMLVYRL 430 440 450 460 470 480 QTQEKPNTTV QVPAFLQELV DRDNSKFEEW CIEMAEMRKQ SVDKGKAKHE EVKELYQRLP 490 500 510 520 530 540 AGAEPYEFVS LEWLQKWLDE STPTKPIDNH ACLCSHDKLH PDKISIMKRI SEYAADIFYS 550 560 570 580 590 600 RYGGGPRLTV KALCKECVVE RCRILRLKNQ LNEDYKTVNN LLKAAVKGSD GFWVGKSSLR 610 620 630 640 650 660 SWRQLALEQL DEQDGDAEQS NGKMNGSTLN KDESKEERKE EEELNFNEDI LCPHGELCIS 670 680 690 700 710 720 ENERRLVSKE AWSKLQQYFP KAPEFPSYKE CCSQCKILER EGEENEALHK MIANEQKTSL 730 740 750 760 770 780 PNLFQDKNRP CLSNWPEDTD VLYIVSQFFV EEWRKFVRKP TRCSPVSSVG NSALLCPHGG 790 800 810 820 830 840 LMFTFASMTK EDSKLIALIW PSEWQMIQKL FVVDHVIKIT RIEVGDVNPS ETQYISEPKL 850 860 870 880 890 900 CPECREGLLC QQQRDLREYT QATIYVHKVV DNKKVMKDSA PELNVSSSET EEDKEEAKPD 910 920 930 940 950 960 GEKDPDFNQI MHAFSVAPFD QNLSIDGKIL SDDCATLGTL GVIPESVILL KADEPIADYA 970 980 AMDDVMQVCM PEEGFKGTGL LGH
	Isoform 3 [UniParc]. Checksum: A7608F78005CF98D	FASTA	703	81,449
	10 20 30 40 50 60 MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCKG NPNCLVGIGE 70 80 90 100 110 120 HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV NTFLQVWFLN LELRQALYLC 130 140 150 160 170 180 PSTCSDYMLG DGIQEEKDYE PQTICEHLQY LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ 190 200 210 220 230 240 DAQEFSKLFM SLLEDTLSKQ KNPDVRNIVQ QQFCGEYAYV TVCNQCGRES KLLSKFYELE 250 260 270 280 290 300 LNIQGHKQLT DCISEFLKEE KLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV 310 320 330 340 350 360 FDRQTGHKKK LNTYIGFSEI LDMEPYVEHK GGSYVYELSA VLIHRGVSAY SGHYIAHVKD 370 380 390 400 410 420 PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL AEPSKSQTRK PKCGKGTHCS RNAYMLVYRL 430 440 450 460 470 480 QTQEKPNTTV QVPAFLQELV DRDNSKFEEW CIEMAEMRKQ SVDKGKAKHE EVKELYQRLP 490 500 510 520 530 540 AGAEPYEFVS LEWLQKWLDE STPTKPIDNH ACLCSHDKLH PDKISIMKRI SEYAADIFYS 550 560 570 580 590 600 RYGGGPRLTV KALCKECVVE RCRILRLKNQ LNEDYKTVNN LLKAAVKGSD GFWVGKSSLR 610 620 630 640 650 660 SWRQLALEQL DEQDGDAEQS NGKMNGSTLN KDESKEERKE EEELNFNEDI LCPHGELCIS 670 680 690 700 ENERRLVSKE AWSKLQQYFP KAPEFPSYKE CCSQCKILER EGE
	Isoform 4 [UniParc]. Checksum: 675B208E4EFA5350	FASTA	392	45,481
	10 20 30 40 50 60 MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCKG NPNCLVGIGE 70 80 90 100 110 120 HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV NTFLQVWFLN LELRQALYLC 130 140 150 160 170 180 PSTCSDYMLG DGIQEEKDYE PQTICEHLQY LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ 190 200 210 220 230 240 DAQEFSKLFM SLLEDTLSKQ KNPDVRNIVQ QQFCGEYAYV TVCNQCGRES KLLSKFYELE 250 260 270 280 290 300 LNIQGHKQLT DCISEFLKEE KLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV 310 320 330 340 350 360 FDRQTGHKKK LNTYIGFSEI LDMEPYVEHK GGSYVYELSA VLIHRGVSAY SGHYIAHVKD 370 380 390 PQSGEWYKLI LNTNYHLPPS PKPIKIKNYN KP
	Isoform 5 [UniParc]. Checksum: 20D3FA1221CF6383	FASTA	521	59,454
	10 20 30 40 50 60 MNLSLSQKTV KIHRLFPMLA FSEPYEFVSL EWLQKWLDES TPTKPIDNHA CLCSHDKLHP 70 80 90 100 110 120 DKISIMKRIS EYAADIFYSR YGGGPRLTVK ALCKECVVER CRILRLKNQL NEDYKTVNNL 130 140 150 160 170 180 LKAAVKGDGF WVGKSSLRSW RQLALEQLDE QDGDAEQSNG KMNGSTLNKD ESKEERKEEE 190 200 210 220 230 240 ELNFNEDILC PHGELCISEN ERRLVSKEAW SKLQQYFPKA PEFPSYKECC SQCKILEREG 250 260 270 280 290 300 EENEALHKMI ANEQKTSLPN LFQDKNRPCL SNWPEDTDVL YIVSQFFVEE WRKFVRKPTR 310 320 330 340 350 360 CSPVSSVGNS ALLCPHGGLM FTFASMTKED SKLIALIWPS EWQMIQKLFV VDHVIKITRI 370 380 390 400 410 420 EVGDVNPSET QYISEPKLCP ECREGLLCQQ QRDLREYTQA TIYVHKVVDN KKVMKDSAPE 430 440 450 460 470 480 LNVSSSETEE DKEEAKPDGE KDPDFNQIMH AFSVAPFDQN LSIDGKILSD DCATLGTLGV 490 500 510 520 IPESVILLKA DEPIADYAAM DDVMQVCMPE EGFKGTGLLG H
	Isoform 6 [UniParc]. Checksum: C8309D66B49A9AF6	FASTA	154	17,094
	10 20 30 40 50 60 MKDSAPELNV SSSETEEDKE EAKPDGEKDP DFNQSNGGTK RQKISHQNYI AYQKQVIRRS 70 80 90 100 110 120 MRHRKVRGEK ALLVSANQTL KELKIQIMHA FSVAPFDQNL SIDGKILSDD CATLGTLGVI 130 140 150 PESVILLKAD EPIADYAAMD DVMQGKDEFV LGIC
	Isoform 7 (USP31S1) [UniParc]. Checksum: E519B70ABF229820	FASTA	485	56,151
	10 20 30 40 50 60 MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCKG NPNCLVGIGE 70 80 90 100 110 120 HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV NTFLQVWFLN LELRQALYLC 130 140 150 160 170 180 PSTCSDYMLG DGIQEEKDYE PQTICEHLQY LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ 190 200 210 220 230 240 DAQEFSKLFM SLLEDTLSKQ KNPDVRNIVQ QQFCGEYAYV TVCNQCGRES KLLSKFYELE 250 260 270 280 290 300 LNIQGHKQLT DCISEFLKEE KLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV 310 320 330 340 350 360 FDRQTGHKKK LNTYIGFSEI LDMEPYVEHK GGSYVYELSA VLIHRGVSAY SGHYIAHVKD 370 380 390 400 410 420 PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL AEPSKSQTRK PKCGKGTHCS RNAYMLVYRL 430 440 450 460 470 480 QTQEKPNTTV QVPAFLQELV DRDNSKFEEW CIEMAEMRKQ SVDKGKAKHE EVKELYQRLP AGAGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis." Lockhart P.J., Hulihan M., Lincoln S., Hussey J., Skipper L., Bisceglio G., Wilkes K., Farrer M.J. DNA Seq. 15:9-14(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 712-1035 (ISOFORM 1). Tissue: Colon, Hepatoma and Placenta.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 399-1035 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-636 (ISOFORMS 1/2). Tissue: Colon, Eye, Pancreas, Skin and Uterus.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 691-1035 (ISOFORM 1). Tissue: Melanoma.
[6]	"Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases." Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C. Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB." Tzimas C., Michailidou G., Arsenakis M., Kieff E., Mosialos G., Hatzivassiliou E.G. Cell. Signal. 18:83-92(2006) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 7), ENZYME ACTIVITY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH RELA AND TRAF2.
[9]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-956, MASS SPECTROMETRY.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886; SER-887 AND SER-888, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886 AND SER-888, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF502942 mRNA. Translation: AAP30832.1. AL590103 Genomic DNA. Translation: CAI12124.1. Sequence problems. AL590103, AL359815 Genomic DNA. Translation: CAI12127.1. AL359815, AL590103 Genomic DNA. Translation: CAI16256.1. AL359815 Genomic DNA. Translation: CAI16260.1. Sequence problems. AK000110 mRNA. Translation: BAA90950.1. AK002190 mRNA. Translation: BAA92128.1. Different initiation. AK026707 mRNA. Translation: BAB15533.1. Frameshift. AK026930 mRNA. Translation: BAB15591.1. BC007326 mRNA. Translation: AAH07326.2. BC013567 mRNA. Translation: AAH13567.1. Different initiation. BC067261 mRNA. Translation: AAH67261.1. Sequence problems. BC103724 mRNA. Translation: AAI03725.1. Sequence problems. BC104896 mRNA. Translation: AAI04897.1. AL834375 mRNA. Translation: CAD39038.1.
IPI	IPI00328815. IPI00414817. IPI00748485. IPI00786950. IPI00787034. IPI00787461. IPI00788045.
RefSeq	NP_001027902.1. NM_001032730.1. NP_115612.4. NM_032236.5.
UniGene	Hs.467524.
3D structure databases
ProteinModelPortal	Q86UV5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86UV5. 2 interactions.
MINT	MINT-7944238.
Protein family/group databases
MEROPS	C19.068.
PTM databases
PhosphoSite	Q86UV5.
Polymorphism databases
DMDM	74750436.
Proteomic databases
PaxDb	Q86UV5.
PRIDE	Q86UV5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308271; ENSP00000309262; ENSG00000090686. ENST00000374732; ENSP00000363864; ENSG00000090686. ENST00000400301; ENSP00000383157; ENSG00000090686. ENST00000421625; ENSP00000406256; ENSG00000090686.
GeneID	84196.
KEGG	hsa:84196.
UCSC	uc001bfa.3. human. uc001bfb.3. human. uc001bfc.3. human. uc001bfd.1. human. uc001bff.3. human.
Organism-specific databases
CTD	84196.
GeneCards	GC01M022004.
HGNC	HGNC:18533. USP48.
HPA	HPA030045. HPA030046. HPA053976.
neXtProt	NX_Q86UV5.
PharmGKB	PA134947522.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5077.
HOVERGEN	HBG080368.
InParanoid	Q86UV5.
KO	K11858.
OrthoDB	EOG4GF3DC.
PhylomeDB	Q86UV5.
Gene expression databases
ArrayExpress	Q86UV5.
Bgee	Q86UV5.
CleanEx	HS_USP31. HS_USP48.
Genevestigator	Q86UV5.
GermOnline	ENSG00000090686. Homo sapiens.
Family and domain databases
InterPro	IPR006615. Pept_C19_DUSP. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR019955. Ubiquitin_supergroup. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS51283. DUSP. 3 hits. PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. PS00972. UCH_2_1. False negative. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	USP48. human.
GenomeRNAi	84196.
NextBio	73598.

Entry information

Entry name

UBP48_HUMAN

Accession

Primary (citable) accession number: Q86UV5
Secondary accession number(s): Q2M3I4 , Q5SZI4, Q5T3T5, Q6NX53, Q8N3F6, Q96F64, Q96IQ3, Q9H5N3, Q9H5T7, Q9NUJ6, Q9NXR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.