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Q86UU9 (TKN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tachykinin-4
Alternative name(s):
Preprotachykinin-C
Short name=PPT-C

Cleaved into the following 3 chains:

  1. Endokinin-A
    Short name=EKA
  2. Endokinin-A/B
    Short name=EKA/B
  3. Endokinin-C
    Short name=EKC
Gene names
Name:TAC4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. Ref.1 Ref.7 Ref.8 Ref.9

Subcellular location

Secreted Probable.

Tissue specificity

Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta. Ref.1 Ref.4 Ref.6

Sequence similarities

Belongs to the tachykinin family.

Sequence caution

The sequence AAI00841.1 differs from that shown. Reason: Intron retention.

The sequence AAI00843.1 differs from that shown. Reason: Intron retention.

The sequence AAI00844.1 differs from that shown. Reason: Intron retention.

The sequence AAN77128.1 differs from that shown. Reason: Intron retention.

The sequence EAW94657.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q86UU9-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: Q86UU9-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     73-83: Missing.
Isoform 3 Ref.1 (identifier: Q86UU9-3)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     84-103: Missing.
Isoform 4 Ref.1 (identifier: Q86UU9-4)

Also known as: Delta;

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     75-105: Missing.
Isoform 5 Ref.3 (identifier: Q86UU9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Peptide21 – 6747Endokinin-A Ref.1
PRO_5000063346
Peptide58 – 6710Endokinin-A/B Ref.1
PRO_0000320011
Propeptide71 – 799 By similarity
PRO_0000320012
Peptide82 – 9514Endokinin-C Ref.1
PRO_5000063347
Propeptide98 – 11316 By similarity Ref.1
PRO_0000320013

Amino acid modifications

Modified residue671Methionine amide Potential Ref.1
Modified residue951Leucine amide Potential Ref.1

Natural variations

Alternative sequence36 – 416Missing in isoform 2, isoform 3, isoform 4 and isoform 5. Ref.1 Ref.3 Ref.5
VSP_052676
Alternative sequence73 – 8311Missing in isoform 2. Ref.1
VSP_052677
Alternative sequence75 – 10531Missing in isoform 4. Ref.1
VSP_052680
Alternative sequence84 – 10320Missing in isoform 3. Ref.1
VSP_052681

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Alpha) [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B8772582351C9163

FASTA11312,305
        10         20         30         40         50         60 
MLPCLALLLL MELSVCTVAG DGGEEQTLST EAETWVIVAL EEGAGPSIQL QLQEVKTGKA 

        70         80         90        100        110 
SQFFGLMGKR VGGRPLIQPR RKKAYQLEHT FQGLLGKRSL FTEGREDEAQ GSE 

« Hide

Isoform 2 (Beta) [UniParc].

Checksum: EAC9D18849DAA790
Show »

FASTA9610,350
Isoform 3 (Gamma) [UniParc].

Checksum: 293F46CBFA82D37C
Show »

FASTA879,360
Isoform 4 (Delta) [UniParc].

Checksum: 7B555CEC96EC1668
Show »

FASTA768,029
Isoform 5 [UniParc].

Checksum: E0DABEE064F1F94C
Show »

FASTA10711,680

References

« Hide 'large scale' references
[1]"Characterization of the endokinins: human tachykinins with cardiovascular activity."
Page N.M., Bell N.J., Gardiner S.M., Manyonda I.T., Brayley K.J., Strange P.G., Lowry P.J.
Proc. Natl. Acad. Sci. U.S.A. 100:6245-6250(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, TISSUE SPECIFICITY.
[2]Page N.M.
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Identification, localization and receptor characterization of novel mammalian substance P-like peptides."
Kurtz M.M., Wang R., Clements M.K., Cascieri M.A., Austin C.P., Cunningham B.R., Chicchi G.G., Liu Q.
Gene 296:205-212(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-72 (ISOFORM 1).
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-72 (ISOFORMS 2/3/4/5).
[6]"Tachykinins and tachykinin receptors in human uterus."
Patak E., Candenas M.L., Pennefather J.N., Ziccone S., Lilley A., Martin J.D., Flores C., Mantecon A.G., Story M.E., Pinto F.M.
Br. J. Pharmacol. 139:523-532(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat."
Yoshioka D., Takebuchi F., Nishimori T., Naono R., Ikeda T., Nakayama T.
Neurosci. Lett. 410:193-197(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing."
Naono R., Nakayama T., Ikeda T., Matsushima O., Nishimori T.
Brain Res. 1165:71-80(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"A role for tachykinins in the regulation of human sperm motility."
Ravina C.G., Seda M., Pinto F.M., Orea A., Fernandez-Sanchez M., Pintado C.O., Candenas M.L.
Hum. Reprod. 22:1617-1625(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF515828 mRNA. Translation: AAP30874.1.
AF515829 mRNA. Translation: AAP30875.1.
AF515830 mRNA. Translation: AAP30876.1.
AF515831 mRNA. Translation: AAP30877.1.
AY471574 mRNA. Translation: AAS46596.1.
CH471109 Genomic DNA. Translation: EAW94657.1. Sequence problems.
AF521560 mRNA. Translation: AAN77128.1. Sequence problems.
BC100840 mRNA. Translation: AAI00841.1. Sequence problems.
BC100842 mRNA. Translation: AAI00843.1. Sequence problems.
BC100843 mRNA. Translation: AAI00844.1. Sequence problems.
CCDSCCDS42357.1. [Q86UU9-1]
CCDS42358.1. [Q86UU9-4]
CCDS42359.1. [Q86UU9-2]
CCDS42360.1. [Q86UU9-3]
CCDS45727.1. [Q86UU9-5]
RefSeqNP_001070971.1. NM_001077503.1. [Q86UU9-2]
NP_001070972.1. NM_001077504.1. [Q86UU9-3]
NP_001070973.1. NM_001077505.1. [Q86UU9-4]
NP_001070974.1. NM_001077506.1. [Q86UU9-5]
NP_733786.2. NM_170685.2. [Q86UU9-1]
XP_006721862.1. XM_006721799.1.
UniGeneHs.652130.

3D structure databases

ProteinModelPortalQ86UU9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129073. 1 interaction.
STRING9606.ENSP00000334042.

Polymorphism databases

DMDM74723510.

Proteomic databases

PaxDbQ86UU9.
PRIDEQ86UU9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326219; ENSP00000325286; ENSG00000176358. [Q86UU9-3]
ENST00000334568; ENSP00000334042; ENSG00000176358. [Q86UU9-1]
ENST00000352793; ENSP00000340461; ENSG00000176358. [Q86UU9-4]
ENST00000398154; ENSP00000381221; ENSG00000176358. [Q86UU9-2]
ENST00000436235; ENSP00000399702; ENSG00000176358. [Q86UU9-5]
GeneID255061.
KEGGhsa:255061.
UCSCuc002ipo.1. human. [Q86UU9-1]
uc002ipp.1. human. [Q86UU9-5]
uc002ipq.1. human. [Q86UU9-3]
uc002ipr.1. human. [Q86UU9-2]
uc002ips.1. human. [Q86UU9-4]

Organism-specific databases

CTD255061.
GeneCardsGC17M047915.
HGNCHGNC:16641. TAC4.
MIM607833. gene.
neXtProtNX_Q86UU9.
PharmGKBPA134944925.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43589.
HOVERGENHBG097570.
InParanoidQ86UU9.
KOK05241.
OMAIFERFVH.
OrthoDBEOG7NSB4F.
PhylomeDBQ86UU9.
TreeFamTF338519.

Gene expression databases

ArrayExpressQ86UU9.
BgeeQ86UU9.
CleanExHS_TAC4.
GenevestigatorQ86UU9.

Family and domain databases

InterProIPR013055. Tachy_Neuro_lke_CS.
[Graphical view]
PROSITEPS00267. TACHYKININ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAC4.
GenomeRNAi255061.
NextBio92462.
PROQ86UU9.
SOURCESearch...

Entry information

Entry nameTKN4_HUMAN
AccessionPrimary (citable) accession number: Q86UU9
Secondary accession number(s): Q2M2P1 expand/collapse secondary AC list , Q6ECK8, Q86UU6, Q86UU7, Q86UU8, Q8IWZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM