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Q86UU9

- TKN4_HUMAN

UniProt

Q86UU9 - TKN4_HUMAN

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Protein

Tachykinin-4

Gene

TAC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.4 Publications

GO - Biological processi

  1. positive regulation of saliva secretion Source: Ensembl
  2. regulation of blood pressure Source: UniProtKB-KW
  3. tachykinin receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hypotensive agent

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-4
Alternative name(s):
Preprotachykinin-C
Short name:
PPT-C
Cleaved into the following 3 chains:
Endokinin-A
Short name:
EKA
Endokinin-A/B
Short name:
EKA/B
Endokinin-C
Short name:
EKC
Gene namesi
Name:TAC4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:16641. TAC4.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944925.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Peptidei21 – 6747Endokinin-APRO_5000063346Add
BLAST
Peptidei58 – 6710Endokinin-A/BPRO_0000320011
Propeptidei71 – 799By similarityPRO_0000320012
Peptidei82 – 9514Endokinin-CPRO_5000063347Add
BLAST
Propeptidei98 – 11316By similarityPRO_0000320013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671Methionine amide1 PublicationSequence Analysis
Modified residuei95 – 951Leucine amide1 PublicationSequence Analysis

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ86UU9.
PRIDEiQ86UU9.

Expressioni

Tissue specificityi

Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.2 Publications

Gene expression databases

BgeeiQ86UU9.
CleanExiHS_TAC4.
ExpressionAtlasiQ86UU9. baseline and differential.
GenevestigatoriQ86UU9.

Interactioni

Protein-protein interaction databases

BioGridi129073. 1 interaction.
STRINGi9606.ENSP00000334042.

Structurei

3D structure databases

ProteinModelPortaliQ86UU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Sequence Analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43589.
GeneTreeiENSGT00390000015220.
HOVERGENiHBG097570.
InParanoidiQ86UU9.
KOiK05241.
OMAiIFERFVH.
OrthoDBiEOG7NSB4F.
PhylomeDBiQ86UU9.
TreeFamiTF338519.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q86UU9-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPCLALLLL MELSVCTVAG DGGEEQTLST EAETWVIVAL EEGAGPSIQL
60 70 80 90 100
QLQEVKTGKA SQFFGLMGKR VGGRPLIQPR RKKAYQLEHT FQGLLGKRSL
110
FTEGREDEAQ GSE
Length:113
Mass (Da):12,305
Last modified:June 1, 2003 - v1
Checksum:iB8772582351C9163
GO
Isoform 21 Publication (identifier: Q86UU9-2) [UniParc]FASTAAdd to Basket

Also known as: Beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     73-83: Missing.

Show »
Length:96
Mass (Da):10,350
Checksum:iEAC9D18849DAA790
GO
Isoform 31 Publication (identifier: Q86UU9-3) [UniParc]FASTAAdd to Basket

Also known as: Gamma1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     84-103: Missing.

Show »
Length:87
Mass (Da):9,360
Checksum:i293F46CBFA82D37C
GO
Isoform 41 Publication (identifier: Q86UU9-4) [UniParc]FASTAAdd to Basket

Also known as: Delta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     75-105: Missing.

Show »
Length:76
Mass (Da):8,029
Checksum:i7B555CEC96EC1668
GO
Isoform 5 (identifier: Q86UU9-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.

Show »
Length:107
Mass (Da):11,680
Checksum:iE0DABEE064F1F94C
GO

Sequence cautioni

The sequence AAI00841.1 differs from that shown. Reason: Intron retention.
The sequence AAI00843.1 differs from that shown. Reason: Intron retention.
The sequence AAI00844.1 differs from that shown. Reason: Intron retention.
The sequence AAN77128.1 differs from that shown. Reason: Intron retention.
The sequence EAW94657.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei36 – 416Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsVSP_052676
Alternative sequencei73 – 8311Missing in isoform 2. 1 PublicationVSP_052677Add
BLAST
Alternative sequencei75 – 10531Missing in isoform 4. 1 PublicationVSP_052680Add
BLAST
Alternative sequencei84 – 10320Missing in isoform 3. 1 PublicationVSP_052681Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF515828 mRNA. Translation: AAP30874.1.
AF515829 mRNA. Translation: AAP30875.1.
AF515830 mRNA. Translation: AAP30876.1.
AF515831 mRNA. Translation: AAP30877.1.
AY471574 mRNA. Translation: AAS46596.1.
CH471109 Genomic DNA. Translation: EAW94657.1. Sequence problems.
AF521560 mRNA. Translation: AAN77128.1. Sequence problems.
BC100840 mRNA. Translation: AAI00841.1. Sequence problems.
BC100842 mRNA. Translation: AAI00843.1. Sequence problems.
BC100843 mRNA. Translation: AAI00844.1. Sequence problems.
CCDSiCCDS42357.1. [Q86UU9-1]
CCDS42358.1. [Q86UU9-4]
CCDS42359.1. [Q86UU9-2]
CCDS42360.1. [Q86UU9-3]
CCDS45727.1. [Q86UU9-5]
RefSeqiNP_001070971.1. NM_001077503.1. [Q86UU9-2]
NP_001070972.1. NM_001077504.1. [Q86UU9-3]
NP_001070973.1. NM_001077505.1. [Q86UU9-4]
NP_001070974.1. NM_001077506.1. [Q86UU9-5]
NP_733786.2. NM_170685.2. [Q86UU9-1]
XP_006721862.1. XM_006721799.1.
UniGeneiHs.652130.

Genome annotation databases

EnsembliENST00000326219; ENSP00000325286; ENSG00000176358. [Q86UU9-3]
ENST00000334568; ENSP00000334042; ENSG00000176358. [Q86UU9-1]
ENST00000352793; ENSP00000340461; ENSG00000176358. [Q86UU9-4]
ENST00000398154; ENSP00000381221; ENSG00000176358. [Q86UU9-2]
ENST00000436235; ENSP00000399702; ENSG00000176358. [Q86UU9-5]
GeneIDi255061.
KEGGihsa:255061.
UCSCiuc002ipo.1. human. [Q86UU9-1]
uc002ipp.1. human. [Q86UU9-5]
uc002ipq.1. human. [Q86UU9-3]
uc002ipr.1. human. [Q86UU9-2]
uc002ips.1. human. [Q86UU9-4]

Polymorphism databases

DMDMi74723510.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF515828 mRNA. Translation: AAP30874.1 .
AF515829 mRNA. Translation: AAP30875.1 .
AF515830 mRNA. Translation: AAP30876.1 .
AF515831 mRNA. Translation: AAP30877.1 .
AY471574 mRNA. Translation: AAS46596.1 .
CH471109 Genomic DNA. Translation: EAW94657.1 . Sequence problems.
AF521560 mRNA. Translation: AAN77128.1 . Sequence problems.
BC100840 mRNA. Translation: AAI00841.1 . Sequence problems.
BC100842 mRNA. Translation: AAI00843.1 . Sequence problems.
BC100843 mRNA. Translation: AAI00844.1 . Sequence problems.
CCDSi CCDS42357.1. [Q86UU9-1 ]
CCDS42358.1. [Q86UU9-4 ]
CCDS42359.1. [Q86UU9-2 ]
CCDS42360.1. [Q86UU9-3 ]
CCDS45727.1. [Q86UU9-5 ]
RefSeqi NP_001070971.1. NM_001077503.1. [Q86UU9-2 ]
NP_001070972.1. NM_001077504.1. [Q86UU9-3 ]
NP_001070973.1. NM_001077505.1. [Q86UU9-4 ]
NP_001070974.1. NM_001077506.1. [Q86UU9-5 ]
NP_733786.2. NM_170685.2. [Q86UU9-1 ]
XP_006721862.1. XM_006721799.1.
UniGenei Hs.652130.

3D structure databases

ProteinModelPortali Q86UU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129073. 1 interaction.
STRINGi 9606.ENSP00000334042.

Polymorphism databases

DMDMi 74723510.

Proteomic databases

PaxDbi Q86UU9.
PRIDEi Q86UU9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326219 ; ENSP00000325286 ; ENSG00000176358 . [Q86UU9-3 ]
ENST00000334568 ; ENSP00000334042 ; ENSG00000176358 . [Q86UU9-1 ]
ENST00000352793 ; ENSP00000340461 ; ENSG00000176358 . [Q86UU9-4 ]
ENST00000398154 ; ENSP00000381221 ; ENSG00000176358 . [Q86UU9-2 ]
ENST00000436235 ; ENSP00000399702 ; ENSG00000176358 . [Q86UU9-5 ]
GeneIDi 255061.
KEGGi hsa:255061.
UCSCi uc002ipo.1. human. [Q86UU9-1 ]
uc002ipp.1. human. [Q86UU9-5 ]
uc002ipq.1. human. [Q86UU9-3 ]
uc002ipr.1. human. [Q86UU9-2 ]
uc002ips.1. human. [Q86UU9-4 ]

Organism-specific databases

CTDi 255061.
GeneCardsi GC17M047915.
HGNCi HGNC:16641. TAC4.
MIMi 607833. gene.
neXtProti NX_Q86UU9.
PharmGKBi PA134944925.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43589.
GeneTreei ENSGT00390000015220.
HOVERGENi HBG097570.
InParanoidi Q86UU9.
KOi K05241.
OMAi IFERFVH.
OrthoDBi EOG7NSB4F.
PhylomeDBi Q86UU9.
TreeFami TF338519.

Miscellaneous databases

GeneWikii TAC4.
GenomeRNAii 255061.
NextBioi 92462.
PROi Q86UU9.
SOURCEi Search...

Gene expression databases

Bgeei Q86UU9.
CleanExi HS_TAC4.
ExpressionAtlasi Q86UU9. baseline and differential.
Genevestigatori Q86UU9.

Family and domain databases

InterProi IPR013055. Tachy_Neuro_lke_CS.
[Graphical view ]
PROSITEi PS00267. TACHYKININ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the endokinins: human tachykinins with cardiovascular activity."
    Page N.M., Bell N.J., Gardiner S.M., Manyonda I.T., Brayley K.J., Strange P.G., Lowry P.J.
    Proc. Natl. Acad. Sci. U.S.A. 100:6245-6250(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, TISSUE SPECIFICITY.
  2. Page N.M.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification, localization and receptor characterization of novel mammalian substance P-like peptides."
    Kurtz M.M., Wang R., Clements M.K., Cascieri M.A., Austin C.P., Cunningham B.R., Chicchi G.G., Liu Q.
    Gene 296:205-212(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-72 (ISOFORM 1).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-72 (ISOFORMS 2/3/4/5).
  6. Cited for: TISSUE SPECIFICITY.
  7. "Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat."
    Yoshioka D., Takebuchi F., Nishimori T., Naono R., Ikeda T., Nakayama T.
    Neurosci. Lett. 410:193-197(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing."
    Naono R., Nakayama T., Ikeda T., Matsushima O., Nishimori T.
    Brain Res. 1165:71-80(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: FUNCTION.

Entry informationi

Entry nameiTKN4_HUMAN
AccessioniPrimary (citable) accession number: Q86UU9
Secondary accession number(s): Q2M2P1
, Q6ECK8, Q86UU6, Q86UU7, Q86UU8, Q8IWZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3