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Q86UU9

- TKN4_HUMAN

UniProt

Q86UU9 - TKN4_HUMAN

Protein

Tachykinin-4

Gene

TAC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.4 Publications

    GO - Biological processi

    1. positive regulation of saliva secretion Source: Ensembl
    2. regulation of blood pressure Source: UniProtKB-KW
    3. tachykinin receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Hypotensive agent

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tachykinin-4
    Alternative name(s):
    Preprotachykinin-C
    Short name:
    PPT-C
    Cleaved into the following 3 chains:
    Endokinin-A
    Short name:
    EKA
    Endokinin-A/B
    Short name:
    EKA/B
    Endokinin-C
    Short name:
    EKC
    Gene namesi
    Name:TAC4Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:16641. TAC4.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134944925.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Peptidei21 – 6747Endokinin-APRO_5000063346Add
    BLAST
    Peptidei58 – 6710Endokinin-A/BPRO_0000320011
    Propeptidei71 – 799By similarityPRO_0000320012
    Peptidei82 – 9514Endokinin-CPRO_5000063347Add
    BLAST
    Propeptidei98 – 11316By similarityPRO_0000320013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei67 – 671Methionine amide1 PublicationSequence Analysis
    Modified residuei95 – 951Leucine amide1 PublicationSequence Analysis

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiQ86UU9.
    PRIDEiQ86UU9.

    Expressioni

    Tissue specificityi

    Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.2 Publications

    Gene expression databases

    ArrayExpressiQ86UU9.
    BgeeiQ86UU9.
    CleanExiHS_TAC4.
    GenevestigatoriQ86UU9.

    Interactioni

    Protein-protein interaction databases

    BioGridi129073. 1 interaction.
    STRINGi9606.ENSP00000334042.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tachykinin family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43589.
    HOVERGENiHBG097570.
    InParanoidiQ86UU9.
    KOiK05241.
    OMAiIFERFVH.
    OrthoDBiEOG7NSB4F.
    PhylomeDBiQ86UU9.
    TreeFamiTF338519.

    Family and domain databases

    InterProiIPR013055. Tachy_Neuro_lke_CS.
    [Graphical view]
    PROSITEiPS00267. TACHYKININ. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q86UU9-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPCLALLLL MELSVCTVAG DGGEEQTLST EAETWVIVAL EEGAGPSIQL    50
    QLQEVKTGKA SQFFGLMGKR VGGRPLIQPR RKKAYQLEHT FQGLLGKRSL 100
    FTEGREDEAQ GSE 113
    Length:113
    Mass (Da):12,305
    Last modified:June 1, 2003 - v1
    Checksum:iB8772582351C9163
    GO
    Isoform 21 Publication (identifier: Q86UU9-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         36-41: Missing.
         73-83: Missing.

    Show »
    Length:96
    Mass (Da):10,350
    Checksum:iEAC9D18849DAA790
    GO
    Isoform 31 Publication (identifier: Q86UU9-3) [UniParc]FASTAAdd to Basket

    Also known as: Gamma1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         36-41: Missing.
         84-103: Missing.

    Show »
    Length:87
    Mass (Da):9,360
    Checksum:i293F46CBFA82D37C
    GO
    Isoform 41 Publication (identifier: Q86UU9-4) [UniParc]FASTAAdd to Basket

    Also known as: Delta1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         36-41: Missing.
         75-105: Missing.

    Show »
    Length:76
    Mass (Da):8,029
    Checksum:i7B555CEC96EC1668
    GO
    Isoform 5 (identifier: Q86UU9-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-41: Missing.

    Show »
    Length:107
    Mass (Da):11,680
    Checksum:iE0DABEE064F1F94C
    GO

    Sequence cautioni

    The sequence AAI00841.1 differs from that shown. Reason: Intron retention.
    The sequence AAI00843.1 differs from that shown. Reason: Intron retention.
    The sequence AAI00844.1 differs from that shown. Reason: Intron retention.
    The sequence AAN77128.1 differs from that shown. Reason: Intron retention.
    The sequence EAW94657.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei36 – 416Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsVSP_052676
    Alternative sequencei73 – 8311Missing in isoform 2. 1 PublicationVSP_052677Add
    BLAST
    Alternative sequencei75 – 10531Missing in isoform 4. 1 PublicationVSP_052680Add
    BLAST
    Alternative sequencei84 – 10320Missing in isoform 3. 1 PublicationVSP_052681Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF515828 mRNA. Translation: AAP30874.1.
    AF515829 mRNA. Translation: AAP30875.1.
    AF515830 mRNA. Translation: AAP30876.1.
    AF515831 mRNA. Translation: AAP30877.1.
    AY471574 mRNA. Translation: AAS46596.1.
    CH471109 Genomic DNA. Translation: EAW94657.1. Sequence problems.
    AF521560 mRNA. Translation: AAN77128.1. Sequence problems.
    BC100840 mRNA. Translation: AAI00841.1. Sequence problems.
    BC100842 mRNA. Translation: AAI00843.1. Sequence problems.
    BC100843 mRNA. Translation: AAI00844.1. Sequence problems.
    CCDSiCCDS42357.1. [Q86UU9-1]
    CCDS42358.1. [Q86UU9-4]
    CCDS42359.1. [Q86UU9-2]
    CCDS42360.1. [Q86UU9-3]
    CCDS45727.1. [Q86UU9-5]
    RefSeqiNP_001070971.1. NM_001077503.1. [Q86UU9-2]
    NP_001070972.1. NM_001077504.1. [Q86UU9-3]
    NP_001070973.1. NM_001077505.1. [Q86UU9-4]
    NP_001070974.1. NM_001077506.1. [Q86UU9-5]
    NP_733786.2. NM_170685.2. [Q86UU9-1]
    XP_006721862.1. XM_006721799.1.
    UniGeneiHs.652130.

    Genome annotation databases

    EnsembliENST00000326219; ENSP00000325286; ENSG00000176358. [Q86UU9-3]
    ENST00000334568; ENSP00000334042; ENSG00000176358. [Q86UU9-1]
    ENST00000352793; ENSP00000340461; ENSG00000176358. [Q86UU9-4]
    ENST00000398154; ENSP00000381221; ENSG00000176358. [Q86UU9-2]
    ENST00000436235; ENSP00000399702; ENSG00000176358. [Q86UU9-5]
    GeneIDi255061.
    KEGGihsa:255061.
    UCSCiuc002ipo.1. human. [Q86UU9-1]
    uc002ipp.1. human. [Q86UU9-5]
    uc002ipq.1. human. [Q86UU9-3]
    uc002ipr.1. human. [Q86UU9-2]
    uc002ips.1. human. [Q86UU9-4]

    Polymorphism databases

    DMDMi74723510.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF515828 mRNA. Translation: AAP30874.1 .
    AF515829 mRNA. Translation: AAP30875.1 .
    AF515830 mRNA. Translation: AAP30876.1 .
    AF515831 mRNA. Translation: AAP30877.1 .
    AY471574 mRNA. Translation: AAS46596.1 .
    CH471109 Genomic DNA. Translation: EAW94657.1 . Sequence problems.
    AF521560 mRNA. Translation: AAN77128.1 . Sequence problems.
    BC100840 mRNA. Translation: AAI00841.1 . Sequence problems.
    BC100842 mRNA. Translation: AAI00843.1 . Sequence problems.
    BC100843 mRNA. Translation: AAI00844.1 . Sequence problems.
    CCDSi CCDS42357.1. [Q86UU9-1 ]
    CCDS42358.1. [Q86UU9-4 ]
    CCDS42359.1. [Q86UU9-2 ]
    CCDS42360.1. [Q86UU9-3 ]
    CCDS45727.1. [Q86UU9-5 ]
    RefSeqi NP_001070971.1. NM_001077503.1. [Q86UU9-2 ]
    NP_001070972.1. NM_001077504.1. [Q86UU9-3 ]
    NP_001070973.1. NM_001077505.1. [Q86UU9-4 ]
    NP_001070974.1. NM_001077506.1. [Q86UU9-5 ]
    NP_733786.2. NM_170685.2. [Q86UU9-1 ]
    XP_006721862.1. XM_006721799.1.
    UniGenei Hs.652130.

    3D structure databases

    ProteinModelPortali Q86UU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129073. 1 interaction.
    STRINGi 9606.ENSP00000334042.

    Polymorphism databases

    DMDMi 74723510.

    Proteomic databases

    PaxDbi Q86UU9.
    PRIDEi Q86UU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326219 ; ENSP00000325286 ; ENSG00000176358 . [Q86UU9-3 ]
    ENST00000334568 ; ENSP00000334042 ; ENSG00000176358 . [Q86UU9-1 ]
    ENST00000352793 ; ENSP00000340461 ; ENSG00000176358 . [Q86UU9-4 ]
    ENST00000398154 ; ENSP00000381221 ; ENSG00000176358 . [Q86UU9-2 ]
    ENST00000436235 ; ENSP00000399702 ; ENSG00000176358 . [Q86UU9-5 ]
    GeneIDi 255061.
    KEGGi hsa:255061.
    UCSCi uc002ipo.1. human. [Q86UU9-1 ]
    uc002ipp.1. human. [Q86UU9-5 ]
    uc002ipq.1. human. [Q86UU9-3 ]
    uc002ipr.1. human. [Q86UU9-2 ]
    uc002ips.1. human. [Q86UU9-4 ]

    Organism-specific databases

    CTDi 255061.
    GeneCardsi GC17M047915.
    HGNCi HGNC:16641. TAC4.
    MIMi 607833. gene.
    neXtProti NX_Q86UU9.
    PharmGKBi PA134944925.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43589.
    HOVERGENi HBG097570.
    InParanoidi Q86UU9.
    KOi K05241.
    OMAi IFERFVH.
    OrthoDBi EOG7NSB4F.
    PhylomeDBi Q86UU9.
    TreeFami TF338519.

    Miscellaneous databases

    GeneWikii TAC4.
    GenomeRNAii 255061.
    NextBioi 92462.
    PROi Q86UU9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UU9.
    Bgeei Q86UU9.
    CleanExi HS_TAC4.
    Genevestigatori Q86UU9.

    Family and domain databases

    InterProi IPR013055. Tachy_Neuro_lke_CS.
    [Graphical view ]
    PROSITEi PS00267. TACHYKININ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the endokinins: human tachykinins with cardiovascular activity."
      Page N.M., Bell N.J., Gardiner S.M., Manyonda I.T., Brayley K.J., Strange P.G., Lowry P.J.
      Proc. Natl. Acad. Sci. U.S.A. 100:6245-6250(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, TISSUE SPECIFICITY.
    2. Page N.M.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Identification, localization and receptor characterization of novel mammalian substance P-like peptides."
      Kurtz M.M., Wang R., Clements M.K., Cascieri M.A., Austin C.P., Cunningham B.R., Chicchi G.G., Liu Q.
      Gene 296:205-212(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-72 (ISOFORM 1).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-72 (ISOFORMS 2/3/4/5).
    6. Cited for: TISSUE SPECIFICITY.
    7. "Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat."
      Yoshioka D., Takebuchi F., Nishimori T., Naono R., Ikeda T., Nakayama T.
      Neurosci. Lett. 410:193-197(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing."
      Naono R., Nakayama T., Ikeda T., Matsushima O., Nishimori T.
      Brain Res. 1165:71-80(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. Cited for: FUNCTION.

    Entry informationi

    Entry nameiTKN4_HUMAN
    AccessioniPrimary (citable) accession number: Q86UU9
    Secondary accession number(s): Q2M2P1
    , Q6ECK8, Q86UU6, Q86UU7, Q86UU8, Q8IWZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3