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Protein

Tachykinin-4

Gene

TAC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.4 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hypotensive agent

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-4
Alternative name(s):
Preprotachykinin-C
Short name:
PPT-C
Cleaved into the following 3 chains:
Endokinin-A
Short name:
EKA
Endokinin-A/B
Short name:
EKA/B
Endokinin-C
Short name:
EKC
Gene namesi
Name:TAC4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16641. TAC4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi255061.
OpenTargetsiENSG00000176358.
PharmGKBiPA134944925.

Polymorphism and mutation databases

BioMutaiTAC4.
DMDMi74723510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PeptideiPRO_500006334621 – 67Endokinin-AAdd BLAST47
PeptideiPRO_000032001158 – 67Endokinin-A/B10
PropeptideiPRO_000032001271 – 79By similarity9
PeptideiPRO_500006334782 – 95Endokinin-CAdd BLAST14
PropeptideiPRO_000032001398 – 113By similarityAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67Methionine amide1 PublicationSequence analysis1
Modified residuei95Leucine amide1 PublicationSequence analysis1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ86UU9.
PRIDEiQ86UU9.

Expressioni

Tissue specificityi

Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.2 Publications

Gene expression databases

BgeeiENSG00000176358.
CleanExiHS_TAC4.
ExpressionAtlasiQ86UU9. baseline and differential.
GenevisibleiQ86UU9. HS.

Organism-specific databases

HPAiCAB009564.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129073. 2 interactors.
STRINGi9606.ENSP00000334042.

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi59 – 61Combined sources3
Helixi62 – 66Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MOCNMR-A57-67[»]
ProteinModelPortaliQ86UU9.
SMRiQ86UU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QI. Eukaryota.
ENOG41113ZV. LUCA.
GeneTreeiENSGT00390000015220.
HOVERGENiHBG097570.
InParanoidiQ86UU9.
KOiK05241.
OMAiHTFQGLL.
OrthoDBiEOG091G0TYJ.
PhylomeDBiQ86UU9.
TreeFamiTF338519.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PROSITEiPS00267. TACHYKININ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q86UU9-1) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPCLALLLL MELSVCTVAG DGGEEQTLST EAETWVIVAL EEGAGPSIQL
60 70 80 90 100
QLQEVKTGKA SQFFGLMGKR VGGRPLIQPR RKKAYQLEHT FQGLLGKRSL
110
FTEGREDEAQ GSE
Length:113
Mass (Da):12,305
Last modified:June 1, 2003 - v1
Checksum:iB8772582351C9163
GO
Isoform 21 Publication (identifier: Q86UU9-2) [UniParc]FASTAAdd to basket
Also known as: Beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     73-83: Missing.

Show »
Length:96
Mass (Da):10,350
Checksum:iEAC9D18849DAA790
GO
Isoform 31 Publication (identifier: Q86UU9-3) [UniParc]FASTAAdd to basket
Also known as: Gamma1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     84-103: Missing.

Show »
Length:87
Mass (Da):9,360
Checksum:i293F46CBFA82D37C
GO
Isoform 41 Publication (identifier: Q86UU9-4) [UniParc]FASTAAdd to basket
Also known as: Delta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     75-105: Missing.

Show »
Length:76
Mass (Da):8,029
Checksum:i7B555CEC96EC1668
GO
Isoform 5 (identifier: Q86UU9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.

Show »
Length:107
Mass (Da):11,680
Checksum:iE0DABEE064F1F94C
GO

Sequence cautioni

The sequence AAI00841 differs from that shown. Intron retention.Curated
The sequence AAI00843 differs from that shown. Intron retention.Curated
The sequence AAI00844 differs from that shown. Intron retention.Curated
The sequence AAN77128 differs from that shown. Intron retention.Curated
The sequence EAW94657 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05267636 – 41Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 Publications6
Alternative sequenceiVSP_05267773 – 83Missing in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_05268075 – 105Missing in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_05268184 – 103Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF515828 mRNA. Translation: AAP30874.1.
AF515829 mRNA. Translation: AAP30875.1.
AF515830 mRNA. Translation: AAP30876.1.
AF515831 mRNA. Translation: AAP30877.1.
AY471574 mRNA. Translation: AAS46596.1.
CH471109 Genomic DNA. Translation: EAW94657.1. Sequence problems.
AF521560 mRNA. Translation: AAN77128.1. Sequence problems.
BC100840 mRNA. Translation: AAI00841.1. Sequence problems.
BC100842 mRNA. Translation: AAI00843.1. Sequence problems.
BC100843 mRNA. Translation: AAI00844.1. Sequence problems.
CCDSiCCDS42357.1. [Q86UU9-1]
CCDS42358.1. [Q86UU9-4]
CCDS42359.1. [Q86UU9-2]
CCDS42360.1. [Q86UU9-3]
CCDS45727.1. [Q86UU9-5]
RefSeqiNP_001070971.1. NM_001077503.1. [Q86UU9-2]
NP_001070972.1. NM_001077504.1. [Q86UU9-3]
NP_001070973.1. NM_001077505.1. [Q86UU9-4]
NP_001070974.1. NM_001077506.1. [Q86UU9-5]
NP_733786.2. NM_170685.2. [Q86UU9-1]
UniGeneiHs.652130.

Genome annotation databases

EnsembliENST00000326219; ENSP00000325286; ENSG00000176358. [Q86UU9-3]
ENST00000334568; ENSP00000334042; ENSG00000176358. [Q86UU9-1]
ENST00000352793; ENSP00000340461; ENSG00000176358. [Q86UU9-4]
ENST00000398154; ENSP00000381221; ENSG00000176358. [Q86UU9-2]
ENST00000436235; ENSP00000399702; ENSG00000176358. [Q86UU9-5]
GeneIDi255061.
KEGGihsa:255061.
UCSCiuc002ipo.1. human. [Q86UU9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF515828 mRNA. Translation: AAP30874.1.
AF515829 mRNA. Translation: AAP30875.1.
AF515830 mRNA. Translation: AAP30876.1.
AF515831 mRNA. Translation: AAP30877.1.
AY471574 mRNA. Translation: AAS46596.1.
CH471109 Genomic DNA. Translation: EAW94657.1. Sequence problems.
AF521560 mRNA. Translation: AAN77128.1. Sequence problems.
BC100840 mRNA. Translation: AAI00841.1. Sequence problems.
BC100842 mRNA. Translation: AAI00843.1. Sequence problems.
BC100843 mRNA. Translation: AAI00844.1. Sequence problems.
CCDSiCCDS42357.1. [Q86UU9-1]
CCDS42358.1. [Q86UU9-4]
CCDS42359.1. [Q86UU9-2]
CCDS42360.1. [Q86UU9-3]
CCDS45727.1. [Q86UU9-5]
RefSeqiNP_001070971.1. NM_001077503.1. [Q86UU9-2]
NP_001070972.1. NM_001077504.1. [Q86UU9-3]
NP_001070973.1. NM_001077505.1. [Q86UU9-4]
NP_001070974.1. NM_001077506.1. [Q86UU9-5]
NP_733786.2. NM_170685.2. [Q86UU9-1]
UniGeneiHs.652130.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MOCNMR-A57-67[»]
ProteinModelPortaliQ86UU9.
SMRiQ86UU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129073. 2 interactors.
STRINGi9606.ENSP00000334042.

Polymorphism and mutation databases

BioMutaiTAC4.
DMDMi74723510.

Proteomic databases

PaxDbiQ86UU9.
PRIDEiQ86UU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326219; ENSP00000325286; ENSG00000176358. [Q86UU9-3]
ENST00000334568; ENSP00000334042; ENSG00000176358. [Q86UU9-1]
ENST00000352793; ENSP00000340461; ENSG00000176358. [Q86UU9-4]
ENST00000398154; ENSP00000381221; ENSG00000176358. [Q86UU9-2]
ENST00000436235; ENSP00000399702; ENSG00000176358. [Q86UU9-5]
GeneIDi255061.
KEGGihsa:255061.
UCSCiuc002ipo.1. human. [Q86UU9-1]

Organism-specific databases

CTDi255061.
DisGeNETi255061.
GeneCardsiTAC4.
HGNCiHGNC:16641. TAC4.
HPAiCAB009564.
MIMi607833. gene.
neXtProtiNX_Q86UU9.
OpenTargetsiENSG00000176358.
PharmGKBiPA134944925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2QI. Eukaryota.
ENOG41113ZV. LUCA.
GeneTreeiENSGT00390000015220.
HOVERGENiHBG097570.
InParanoidiQ86UU9.
KOiK05241.
OMAiHTFQGLL.
OrthoDBiEOG091G0TYJ.
PhylomeDBiQ86UU9.
TreeFamiTF338519.

Miscellaneous databases

GeneWikiiTAC4.
GenomeRNAii255061.
PROiQ86UU9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176358.
CleanExiHS_TAC4.
ExpressionAtlasiQ86UU9. baseline and differential.
GenevisibleiQ86UU9. HS.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PROSITEiPS00267. TACHYKININ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTKN4_HUMAN
AccessioniPrimary (citable) accession number: Q86UU9
Secondary accession number(s): Q2M2P1
, Q6ECK8, Q86UU6, Q86UU7, Q86UU8, Q8IWZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.