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Protein

Gametogenetin

Gene

GGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Gametogenetin
Gene namesi
Name:GGN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18869. GGN.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903452.

Polymorphism and mutation databases

BioMutaiGGN.
DMDMi108935993.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 652652GametogenetinPRO_0000239342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei389 – 3891PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86UU5.
PaxDbiQ86UU5.
PeptideAtlasiQ86UU5.
PRIDEiQ86UU5.

PTM databases

iPTMnetiQ86UU5.
PhosphoSiteiQ86UU5.

Expressioni

Gene expression databases

BgeeiQ86UU5.
CleanExiHS_GGN.
ExpressionAtlasiQ86UU5. baseline and differential.
GenevisibleiQ86UU5. HS.

Organism-specific databases

HPAiHPA031819.

Interactioni

Subunit structurei

Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-10259069,EBI-10171697

Protein-protein interaction databases

BioGridi128266. 3 interactions.
IntActiQ86UU5. 1 interaction.
STRINGi9606.ENSP00000334940.

Structurei

3D structure databases

ProteinModelPortaliQ86UU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 486364Interaction with GGNBP1By similarityAdd
BLAST
Regioni491 – 652162Interactions with ZNF403/GGNBP2 and OAZ3By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 520469Pro-richAdd
BLAST
Compositional biasi561 – 5688Poly-Gly

Phylogenomic databases

eggNOGiENOG410IVS8. Eukaryota.
ENOG41115RQ. LUCA.
GeneTreeiENSGT00700000104635.
HOGENOMiHOG000112718.
HOVERGENiHBG081555.
InParanoidiQ86UU5.
OMAiRGLGVWF.
OrthoDBiEOG74FF17.
PhylomeDBiQ86UU5.
TreeFamiTF337083.

Family and domain databases

InterProiIPR031400. GGN.
[Graphical view]
PfamiPF15685. GGN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNLQSEPSA GGGSRKVQPS DRAPDSRRTS LVEPEMTSQA MRLTRGLGVW
60 70 80 90 100
FPGSATPPGL MVPREPQASP STLPLTLERP SPVMPPPEEA AAVSAPPPAP
110 120 130 140 150
AGTLLPGPSK WQKPAGTPVP RIRRLLEASH RGQGDPPSLR PLKPPPPPRQ
160 170 180 190 200
LSVKDTVPRA PSQFPPPLET WKPPPPLPSE RQPADRRITP ALATPASPPT
210 220 230 240 250
ESQAGPRNQG QTAGRARGGA PPHAGEGEMA QPADSESGLS LLCKITFKSR
260 270 280 290 300
PSLAPPAASS SLAAKASLGG GGGGGLFAAS GAISYAEVLK QGPLPPGAAR
310 320 330 340 350
PLGEVSRGAQ EAEGGDGDGE GCSGPPSAPA SQARALPPPP YTTFPGSKPK
360 370 380 390 400
FDWVSAPDGP ERHFRFNGAG GGIGAPRRRA AALSGPWGSP PPPPEQIHSA
410 420 430 440 450
PGPRRPAPAL LAPPTFIFPA PTNGEPMRPG PPGLQELPPL PPPTPPPTLQ
460 470 480 490 500
PPALQPTPLP VAPPLTPGLG HKESALAPTA APALPPALAA DQAPAPSPAP
510 520 530 540 550
APTVAEPSPP VSAPAPAAAP IKTRTRRNKG SRAARGATRK DGLHGDGPRE
560 570 580 590 600
RATATVPDSS GGGGGGSGAS QTGAANTRAA RHWLPFQVLN SCPCKCYCHH
610 620 630 640 650
QPRHRRLPRN VSAWLSTSTN HLGEPPWVAT IKLSGSLVAK LEHYDLQATH

SN
Length:652
Mass (Da):66,699
Last modified:June 13, 2006 - v2
Checksum:i94E88A5409FA7647
GO
Isoform 2 (identifier: Q86UU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.
     540-540: K → A
     541-652: Missing.

Show »
Length:457
Mass (Da):45,949
Checksum:i990649C0D6456721
GO
Isoform 3 (identifier: Q86UU5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-224: SPPTESQAGPRNQGQTAGRARGGAPPHA → CVRARTRGCAHQDPHAQEQGFPCSPGRD
     225-652: Missing.

Show »
Length:224
Mass (Da):23,865
Checksum:iA8574AA29A66AB7A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801P → A in AAP31500 (PubMed:12574169).Curated
Sequence conflicti80 – 801P → A in AAP31501 (PubMed:12574169).Curated
Sequence conflicti113 – 1131K → R in DAA00240 (PubMed:12574169).Curated
Sequence conflicti166 – 1672PP → AH in AAP31500 (PubMed:12574169).Curated
Sequence conflicti166 – 1672PP → AH in AAP31501 (PubMed:12574169).Curated
Sequence conflicti174 – 1752PP → SR in AAP31500 (PubMed:12574169).Curated
Sequence conflicti195 – 1951P → T in AAP31500 (PubMed:12574169).Curated
Sequence conflicti198 – 1981P → T in AAP31500 (PubMed:12574169).Curated
Sequence conflicti212 – 2121T → K in AAP31500 (PubMed:12574169).Curated
Sequence conflicti219 – 2191G → R in AAP31500 (PubMed:12574169).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383Missing in isoform 2. CuratedVSP_019166Add
BLAST
Alternative sequencei197 – 22428SPPTE…APPHA → CVRARTRGCAHQDPHAQEQG FPCSPGRD in isoform 3. 1 PublicationVSP_019167Add
BLAST
Alternative sequencei225 – 652428Missing in isoform 3. 1 PublicationVSP_019168Add
BLAST
Alternative sequencei540 – 5401K → A in isoform 2. CuratedVSP_019169
Alternative sequencei541 – 652112Missing in isoform 2. CuratedVSP_019170Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF538035 mRNA. Translation: AAP31500.1.
AF538036 mRNA. Translation: AAP31501.1.
BK000550 mRNA. Translation: DAA00240.1.
AK093032 mRNA. Translation: BAC04025.1.
BC035008 mRNA. Translation: AAH35008.1.
CCDSiCCDS12516.1. [Q86UU5-1]
RefSeqiNP_689870.3. NM_152657.3. [Q86UU5-1]
XP_005258676.1. XM_005258619.3. [Q86UU5-1]
UniGeneiHs.447948.

Genome annotation databases

EnsembliENST00000334928; ENSP00000334940; ENSG00000179168. [Q86UU5-1]
ENST00000585737; ENSP00000467295; ENSG00000179168. [Q86UU5-2]
GeneIDi199720.
KEGGihsa:199720.
UCSCiuc002oij.2. human. [Q86UU5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF538035 mRNA. Translation: AAP31500.1.
AF538036 mRNA. Translation: AAP31501.1.
BK000550 mRNA. Translation: DAA00240.1.
AK093032 mRNA. Translation: BAC04025.1.
BC035008 mRNA. Translation: AAH35008.1.
CCDSiCCDS12516.1. [Q86UU5-1]
RefSeqiNP_689870.3. NM_152657.3. [Q86UU5-1]
XP_005258676.1. XM_005258619.3. [Q86UU5-1]
UniGeneiHs.447948.

3D structure databases

ProteinModelPortaliQ86UU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128266. 3 interactions.
IntActiQ86UU5. 1 interaction.
STRINGi9606.ENSP00000334940.

PTM databases

iPTMnetiQ86UU5.
PhosphoSiteiQ86UU5.

Polymorphism and mutation databases

BioMutaiGGN.
DMDMi108935993.

Proteomic databases

EPDiQ86UU5.
PaxDbiQ86UU5.
PeptideAtlasiQ86UU5.
PRIDEiQ86UU5.

Protocols and materials databases

DNASUi199720.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334928; ENSP00000334940; ENSG00000179168. [Q86UU5-1]
ENST00000585737; ENSP00000467295; ENSG00000179168. [Q86UU5-2]
GeneIDi199720.
KEGGihsa:199720.
UCSCiuc002oij.2. human. [Q86UU5-1]

Organism-specific databases

CTDi199720.
GeneCardsiGGN.
HGNCiHGNC:18869. GGN.
HPAiHPA031819.
MIMi609966. gene.
neXtProtiNX_Q86UU5.
PharmGKBiPA134903452.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVS8. Eukaryota.
ENOG41115RQ. LUCA.
GeneTreeiENSGT00700000104635.
HOGENOMiHOG000112718.
HOVERGENiHBG081555.
InParanoidiQ86UU5.
OMAiRGLGVWF.
OrthoDBiEOG74FF17.
PhylomeDBiQ86UU5.
TreeFamiTF337083.

Miscellaneous databases

GenomeRNAii199720.
PROiQ86UU5.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UU5.
CleanExiHS_GGN.
ExpressionAtlasiQ86UU5. baseline and differential.
GenevisibleiQ86UU5. HS.

Family and domain databases

InterProiIPR031400. GGN.
[Graphical view]
PfamiPF15685. GGN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis."
    Lu B., Bishop C.E.
    J. Biol. Chem. 278:16289-16296(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), ALTERNATIVE SPLICING (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiGGN_HUMAN
AccessioniPrimary (citable) accession number: Q86UU5
Secondary accession number(s): Q7RTU6, Q86UU4, Q8NAA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: July 6, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.