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Protein

Pleckstrin homology-like domain family B member 1

Gene

PHLDB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family B member 1
Alternative name(s):
Protein LL5-alpha
Gene namesi
Name:PHLDB1
Synonyms:KIAA0638, LL5A
ORF Names:DLNB07
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23697. PHLDB1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917952.

Polymorphism and mutation databases

BioMutaiPHLDB1.
DMDMi74723506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13771377Pleckstrin homology-like domain family B member 1PRO_0000053891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201Phosphoserine1 Publication
Modified residuei223 – 2231Phosphoserine1 Publication
Modified residuei324 – 3241Phosphoserine2 Publications
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei430 – 4301Phosphoserine1 Publication
Modified residuei443 – 4431Phosphoserine1 Publication
Modified residuei501 – 5011Phosphoserine3 Publications
Modified residuei518 – 5181PhosphoserineBy similarity
Modified residuei520 – 5201Phosphoserine2 Publications
Modified residuei522 – 5221Phosphothreonine1 Publication
Modified residuei551 – 5511Phosphoserine1 Publication
Modified residuei555 – 5551Phosphoserine1 Publication
Modified residuei583 – 5831Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86UU1.
PaxDbiQ86UU1.
PRIDEiQ86UU1.

PTM databases

PhosphoSiteiQ86UU1.

Expressioni

Gene expression databases

BgeeiQ86UU1.
CleanExiHS_PHLDB1.
ExpressionAtlasiQ86UU1. baseline and differential.
GenevisibleiQ86UU1. HS.

Organism-specific databases

HPAiHPA037959.
HPA038448.

Interactioni

Protein-protein interaction databases

BioGridi116797. 4 interactions.
IntActiQ86UU1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ86UU1.
SMRiQ86UU1. Positions 28-139, 1261-1365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 12562FHAAdd
BLAST
Domaini1256 – 1370115PHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili683 – 809127Sequence AnalysisAdd
BLAST
Coiled coili1144 – 120865Sequence AnalysisAdd
BLAST

Domaini

The PH domain mediates the binding to phosphoinositides.

Sequence similaritiesi

Contains 1 FHA domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG86245.
GeneTreeiENSGT00530000063148.
HOGENOMiHOG000286004.
HOVERGENiHBG080571.
InParanoidiQ86UU1.
OMAiRLWESME.
OrthoDBiEOG779NX9.
PhylomeDBiQ86UU1.
TreeFamiTF329165.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALNRNQIG PGCQTQTMVQ KGPLDLIETG KGLKVQTDKP HLVSLGSGRL
60 70 80 90 100
STAITLLPLE EGRTVIGSAA RDISLQGPGL APEHCYIENL RGTLTLYPCG
110 120 130 140 150
NACTIDGLPV RQPTRLTQGC MLCLGQSTFL RFNHPAEAKW MKSMIPAGGR
160 170 180 190 200
APGPPYSPVP AESESLVNGN HTPQTATRGP SACASHSSLV SSIEKDLQEI
210 220 230 240 250
MDSLVLEEPG AAGKKPAATS PLSPMANGGR YLLSPPTSPG AMSVGSSYEN
260 270 280 290 300
TSPAFSPLSS PASSGSCASH SPSGQEPGPS VPPLVPARSS SYHLALQPPQ
310 320 330 340 350
SRPSGARSES PRLSRKGGHE RPPSPGLRGL LTDSPAATVL AEARRATESP
360 370 380 390 400
RLGGQLPVVA ISLSEYPASG ALSQPTSIPG SPKFQPPVPA PRNKIGTLQD
410 420 430 440 450
RPPSPFREPP GSERVLTTSP SRQLVGRTFS DGLATRTLQP PESPRLGRRG
460 470 480 490 500
LDSMRELPPL SPSLSRRALS PLPTRTTPDP KLNREVAESP RPRRWAAHGA
510 520 530 540 550
SPEDFSLTLG ARGRRTRSPS PTLGESLAPH KGSFSGRLSP AYSLGSLTGA
560 570 580 590 600
SPCQSPCVQR KLSSGDLRVP VTRERKNSIT EISDNEDDLL EYHRRQRQER
610 620 630 640 650
LREQEMERLE RQRLETILNL CAEYSRADGG PEAGELPSIG EATAALALAG
660 670 680 690 700
RRPSRGLAGA SGRSSEEPGV ATQRLWESME RSDEENLKEE CSSTESTQQE
710 720 730 740 750
HEDAPSTKLQ GEVLALEEER AQVLGHVEQL KVRVKELEQQ LQESAREAEM
760 770 780 790 800
ERALLQGERE AERALLQKEQ KAVDQLQEKL VALETGIQKE RDKEAEALET
810 820 830 840 850
ETKLFEDLEF QQLERESRVE EERELAGQGL LRSKAELLRS IAKRKERLAI
860 870 880 890 900
LDSQAGQIRA QAVQESERLA RDKNASLQLL QKEKEKLTVL ERRYHSLTGG
910 920 930 940 950
RPFPKTTSTL KEMEKLLLPA VDLEQWYQEL MAGLGTGPAA ASPHSSPPPL
960 970 980 990 1000
PAKASRQLQV YRSKMDGEAT SPLPRTRSGP LPSSSGSSSS SSQLSVATLG
1010 1020 1030 1040 1050
RSPSPKSALL TQNGTGSLPR NLAATLQDIE TKRQLALQQK GQQVIEEQRR
1060 1070 1080 1090 1100
RLAELKQKAA AEAQCQWDAL HGAAPFPAGP SGFPPLMHHS ILHHLPAGRE
1110 1120 1130 1140 1150
RGEEGEHAYD TLSLESSDSM ETSISTGGNS ACSPDNMSSA SGLDMGKIEE
1160 1170 1180 1190 1200
MEKMLKEAHA EKNRLMESRE REMELRRQAL EEERRRREQV ERRLQSESAR
1210 1220 1230 1240 1250
RQQLVEKEVK MREKQFSQAR PLTRYLPIRK EDFDLKTHIE SSGHGVDTCL
1260 1270 1280 1290 1300
HVVLSSKVCR GYLVKMGGKI KSWKKRWFVF DRLKRTLSYY VDKHETKLKG
1310 1320 1330 1340 1350
VIYFQAIEEV YYDHLRSAAK KRFFRFTMVT ESPNPALTFC VKTHDRLYYM
1360 1370
VAPSAEAMRI WMDVIVTGAE GYTQFMN
Note: Minor.
Length:1,377
Mass (Da):151,162
Last modified:June 1, 2003 - v1
Checksum:iDA2829CC9C2ECD3D
GO
Isoform 2 (identifier: Q86UU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     913-959: Missing.
     1321-1331: Missing.

Note: Major.
Show »
Length:1,319
Mass (Da):144,739
Checksum:iFC6698DAB7F99188
GO
Isoform 3 (identifier: Q86UU1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     913-959: Missing.
     1042-1042: Q → E
     1043-1377: Missing.

Note: No experimental confirmation available.
Show »
Length:995
Mass (Da):107,381
Checksum:iD11D43C8C73BB999
GO

Sequence cautioni

The sequence BAA31613.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB84896.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei913 – 95947Missing in isoform 2 and isoform 3. 2 PublicationsVSP_016737Add
BLAST
Alternative sequencei1042 – 10421Q → E in isoform 3. 1 PublicationVSP_016738
Alternative sequencei1043 – 1377335Missing in isoform 3. 1 PublicationVSP_016739Add
BLAST
Alternative sequencei1321 – 133111Missing in isoform 2. 1 PublicationVSP_016740Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB094090 mRNA. Translation: BAC76044.1.
AB014538 mRNA. Translation: BAA31613.2. Different initiation.
AK074070 mRNA. Translation: BAB84896.2. Different initiation.
EF445008 Genomic DNA. Translation: ACA06043.1.
EF445008 Genomic DNA. Translation: ACA06041.1.
AP000941 Genomic DNA. No translation available.
AP002954 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67401.1.
BC098586 mRNA. Translation: AAH98586.1.
CCDSiCCDS44750.1. [Q86UU1-2]
CCDS8401.1. [Q86UU1-1]
RefSeqiNP_001138230.1. NM_001144758.2. [Q86UU1-1]
NP_001138231.1. NM_001144759.2. [Q86UU1-2]
NP_055972.1. NM_015157.3. [Q86UU1-1]
UniGeneiHs.504062.

Genome annotation databases

EnsembliENST00000356063; ENSP00000348359; ENSG00000019144. [Q86UU1-2]
ENST00000361417; ENSP00000354498; ENSG00000019144. [Q86UU1-1]
ENST00000528594; ENSP00000435520; ENSG00000019144. [Q86UU1-3]
ENST00000530994; ENSP00000431508; ENSG00000019144. [Q86UU1-3]
ENST00000600882; ENSP00000469820; ENSG00000019144. [Q86UU1-1]
GeneIDi23187.
KEGGihsa:23187.
UCSCiuc001ptr.2. human. [Q86UU1-1]
uc001ptt.3. human. [Q86UU1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB094090 mRNA. Translation: BAC76044.1.
AB014538 mRNA. Translation: BAA31613.2. Different initiation.
AK074070 mRNA. Translation: BAB84896.2. Different initiation.
EF445008 Genomic DNA. Translation: ACA06043.1.
EF445008 Genomic DNA. Translation: ACA06041.1.
AP000941 Genomic DNA. No translation available.
AP002954 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67401.1.
BC098586 mRNA. Translation: AAH98586.1.
CCDSiCCDS44750.1. [Q86UU1-2]
CCDS8401.1. [Q86UU1-1]
RefSeqiNP_001138230.1. NM_001144758.2. [Q86UU1-1]
NP_001138231.1. NM_001144759.2. [Q86UU1-2]
NP_055972.1. NM_015157.3. [Q86UU1-1]
UniGeneiHs.504062.

3D structure databases

ProteinModelPortaliQ86UU1.
SMRiQ86UU1. Positions 28-139, 1261-1365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116797. 4 interactions.
IntActiQ86UU1. 1 interaction.

PTM databases

PhosphoSiteiQ86UU1.

Polymorphism and mutation databases

BioMutaiPHLDB1.
DMDMi74723506.

Proteomic databases

MaxQBiQ86UU1.
PaxDbiQ86UU1.
PRIDEiQ86UU1.

Protocols and materials databases

DNASUi23187.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356063; ENSP00000348359; ENSG00000019144. [Q86UU1-2]
ENST00000361417; ENSP00000354498; ENSG00000019144. [Q86UU1-1]
ENST00000528594; ENSP00000435520; ENSG00000019144. [Q86UU1-3]
ENST00000530994; ENSP00000431508; ENSG00000019144. [Q86UU1-3]
ENST00000600882; ENSP00000469820; ENSG00000019144. [Q86UU1-1]
GeneIDi23187.
KEGGihsa:23187.
UCSCiuc001ptr.2. human. [Q86UU1-1]
uc001ptt.3. human. [Q86UU1-2]

Organism-specific databases

CTDi23187.
GeneCardsiGC11P118478.
HGNCiHGNC:23697. PHLDB1.
HPAiHPA037959.
HPA038448.
MIMi612834. gene.
neXtProtiNX_Q86UU1.
PharmGKBiPA134917952.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG86245.
GeneTreeiENSGT00530000063148.
HOGENOMiHOG000286004.
HOVERGENiHBG080571.
InParanoidiQ86UU1.
OMAiRLWESME.
OrthoDBiEOG779NX9.
PhylomeDBiQ86UU1.
TreeFamiTF329165.

Miscellaneous databases

ChiTaRSiPHLDB1. human.
GeneWikiiPHLDB1.
GenomeRNAii23187.
NextBioi44659.
PROiQ86UU1.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UU1.
CleanExiHS_PHLDB1.
ExpressionAtlasiQ86UU1. baseline and differential.
GenevisibleiQ86UU1. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a 500-kb region of common allelic loss in chromosome 11q23 in non-MYCN amplified type of neuroblastoma."
    Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T., Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  5. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  9. "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities."
    Dowler S.J., Currie R.A., Campbell D.G., Deak M., Kular G., Downes C.P., Alessi D.R.
    Biochem. J. 351:19-31(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: BINDING TO PHOSPHOINOSITIDES.
  10. "Identification and characterization of human LL5A gene and mouse Ll5a gene in silico."
    Katoh M., Katoh M.
    Int. J. Oncol. 23:1477-1483(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220; SER-223; SER-430; SER-443; SER-501; SER-520; SER-551; SER-555 AND SER-583, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520 AND THR-522, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPHLB1_HUMAN
AccessioniPrimary (citable) accession number: Q86UU1
Secondary accession number(s): B0YJ63
, B0YJ64, O75133, Q4KMF8, Q8TEQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2003
Last modified: June 24, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.