Q86UU1 (PHLB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pleckstrin homology-like domain family B member 1

Alternative name(s):
Protein LL5-alpha

Gene names

Name:	PHLDB1
Synonyms:	KIAA0638, LL5A
ORF Names:	DLNB07

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1377 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Domain	The PH domain mediates the binding to phosphoinositides.
Sequence similarities	Contains 1 FHA domain. Contains 1 PH domain.
Sequence caution	The sequence BAA31613.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB84896.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86UU1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Minor.

Isoform 2 (identifier: Q86UU1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     913-959: Missing.
     1321-1331: Missing.

Note: Major.

Isoform 3 (identifier: Q86UU1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     913-959: Missing.
     1042-1042: Q → E
     1043-1377: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1377	1377	Pleckstrin homology-like domain family B member 1		PRO_0000053891
Regions
	Domain	64 – 125	62	FHA
	Domain	1256 – 1370	115	PH
	Coiled coil	683 – 809	127	Potential
	Coiled coil	1144 – 1208	65	Potential
Amino acid modifications
	Modified residue	220	1	Phosphoserine Ref.13
	Modified residue	223	1	Phosphoserine Ref.13
	Modified residue	324	1	Phosphoserine Ref.11
	Modified residue	430	1	Phosphoserine Ref.13
	Modified residue	443	1	Phosphoserine Ref.13
	Modified residue	501	1	Phosphoserine Ref.12 Ref.13 Ref.14
	Modified residue	518	1	Phosphoserine By similarity
	Modified residue	520	1	Phosphoserine Ref.13 Ref.15
	Modified residue	522	1	Phosphothreonine Ref.15
	Modified residue	551	1	Phosphoserine Ref.13
	Modified residue	555	1	Phosphoserine Ref.13
	Modified residue	563	1	Phosphoserine By similarity
	Modified residue	583	1	Phosphoserine Ref.13
Natural variations
	Alternative sequence	913 – 959	47	Missing in isoform 2 and isoform 3.		VSP_016737
	Alternative sequence	1042	1	Q → E in isoform 3.		VSP_016738
	Alternative sequence	1043 – 1377	335	Missing in isoform 3.		VSP_016739
	Alternative sequence	1321 – 1331	11	Missing in isoform 2.		VSP_016740

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: DA2829CC9C2ECD3D	FASTA	1,377	151,162
	10 20 30 40 50 60 MDALNRNQIG PGCQTQTMVQ KGPLDLIETG KGLKVQTDKP HLVSLGSGRL STAITLLPLE 70 80 90 100 110 120 EGRTVIGSAA RDISLQGPGL APEHCYIENL RGTLTLYPCG NACTIDGLPV RQPTRLTQGC 130 140 150 160 170 180 MLCLGQSTFL RFNHPAEAKW MKSMIPAGGR APGPPYSPVP AESESLVNGN HTPQTATRGP 190 200 210 220 230 240 SACASHSSLV SSIEKDLQEI MDSLVLEEPG AAGKKPAATS PLSPMANGGR YLLSPPTSPG 250 260 270 280 290 300 AMSVGSSYEN TSPAFSPLSS PASSGSCASH SPSGQEPGPS VPPLVPARSS SYHLALQPPQ 310 320 330 340 350 360 SRPSGARSES PRLSRKGGHE RPPSPGLRGL LTDSPAATVL AEARRATESP RLGGQLPVVA 370 380 390 400 410 420 ISLSEYPASG ALSQPTSIPG SPKFQPPVPA PRNKIGTLQD RPPSPFREPP GSERVLTTSP 430 440 450 460 470 480 SRQLVGRTFS DGLATRTLQP PESPRLGRRG LDSMRELPPL SPSLSRRALS PLPTRTTPDP 490 500 510 520 530 540 KLNREVAESP RPRRWAAHGA SPEDFSLTLG ARGRRTRSPS PTLGESLAPH KGSFSGRLSP 550 560 570 580 590 600 AYSLGSLTGA SPCQSPCVQR KLSSGDLRVP VTRERKNSIT EISDNEDDLL EYHRRQRQER 610 620 630 640 650 660 LREQEMERLE RQRLETILNL CAEYSRADGG PEAGELPSIG EATAALALAG RRPSRGLAGA 670 680 690 700 710 720 SGRSSEEPGV ATQRLWESME RSDEENLKEE CSSTESTQQE HEDAPSTKLQ GEVLALEEER 730 740 750 760 770 780 AQVLGHVEQL KVRVKELEQQ LQESAREAEM ERALLQGERE AERALLQKEQ KAVDQLQEKL 790 800 810 820 830 840 VALETGIQKE RDKEAEALET ETKLFEDLEF QQLERESRVE EERELAGQGL LRSKAELLRS 850 860 870 880 890 900 IAKRKERLAI LDSQAGQIRA QAVQESERLA RDKNASLQLL QKEKEKLTVL ERRYHSLTGG 910 920 930 940 950 960 RPFPKTTSTL KEMEKLLLPA VDLEQWYQEL MAGLGTGPAA ASPHSSPPPL PAKASRQLQV 970 980 990 1000 1010 1020 YRSKMDGEAT SPLPRTRSGP LPSSSGSSSS SSQLSVATLG RSPSPKSALL TQNGTGSLPR 1030 1040 1050 1060 1070 1080 NLAATLQDIE TKRQLALQQK GQQVIEEQRR RLAELKQKAA AEAQCQWDAL HGAAPFPAGP 1090 1100 1110 1120 1130 1140 SGFPPLMHHS ILHHLPAGRE RGEEGEHAYD TLSLESSDSM ETSISTGGNS ACSPDNMSSA 1150 1160 1170 1180 1190 1200 SGLDMGKIEE MEKMLKEAHA EKNRLMESRE REMELRRQAL EEERRRREQV ERRLQSESAR 1210 1220 1230 1240 1250 1260 RQQLVEKEVK MREKQFSQAR PLTRYLPIRK EDFDLKTHIE SSGHGVDTCL HVVLSSKVCR 1270 1280 1290 1300 1310 1320 GYLVKMGGKI KSWKKRWFVF DRLKRTLSYY VDKHETKLKG VIYFQAIEEV YYDHLRSAAK 1330 1340 1350 1360 1370 KRFFRFTMVT ESPNPALTFC VKTHDRLYYM VAPSAEAMRI WMDVIVTGAE GYTQFMN
	Isoform 2 [UniParc]. Checksum: FC6698DAB7F99188	FASTA	1,319	144,739
	10 20 30 40 50 60 MDALNRNQIG PGCQTQTMVQ KGPLDLIETG KGLKVQTDKP HLVSLGSGRL STAITLLPLE 70 80 90 100 110 120 EGRTVIGSAA RDISLQGPGL APEHCYIENL RGTLTLYPCG NACTIDGLPV RQPTRLTQGC 130 140 150 160 170 180 MLCLGQSTFL RFNHPAEAKW MKSMIPAGGR APGPPYSPVP AESESLVNGN HTPQTATRGP 190 200 210 220 230 240 SACASHSSLV SSIEKDLQEI MDSLVLEEPG AAGKKPAATS PLSPMANGGR YLLSPPTSPG 250 260 270 280 290 300 AMSVGSSYEN TSPAFSPLSS PASSGSCASH SPSGQEPGPS VPPLVPARSS SYHLALQPPQ 310 320 330 340 350 360 SRPSGARSES PRLSRKGGHE RPPSPGLRGL LTDSPAATVL AEARRATESP RLGGQLPVVA 370 380 390 400 410 420 ISLSEYPASG ALSQPTSIPG SPKFQPPVPA PRNKIGTLQD RPPSPFREPP GSERVLTTSP 430 440 450 460 470 480 SRQLVGRTFS DGLATRTLQP PESPRLGRRG LDSMRELPPL SPSLSRRALS PLPTRTTPDP 490 500 510 520 530 540 KLNREVAESP RPRRWAAHGA SPEDFSLTLG ARGRRTRSPS PTLGESLAPH KGSFSGRLSP 550 560 570 580 590 600 AYSLGSLTGA SPCQSPCVQR KLSSGDLRVP VTRERKNSIT EISDNEDDLL EYHRRQRQER 610 620 630 640 650 660 LREQEMERLE RQRLETILNL CAEYSRADGG PEAGELPSIG EATAALALAG RRPSRGLAGA 670 680 690 700 710 720 SGRSSEEPGV ATQRLWESME RSDEENLKEE CSSTESTQQE HEDAPSTKLQ GEVLALEEER 730 740 750 760 770 780 AQVLGHVEQL KVRVKELEQQ LQESAREAEM ERALLQGERE AERALLQKEQ KAVDQLQEKL 790 800 810 820 830 840 VALETGIQKE RDKEAEALET ETKLFEDLEF QQLERESRVE EERELAGQGL LRSKAELLRS 850 860 870 880 890 900 IAKRKERLAI LDSQAGQIRA QAVQESERLA RDKNASLQLL QKEKEKLTVL ERRYHSLTGG 910 920 930 940 950 960 RPFPKTTSTL KEVYRSKMDG EATSPLPRTR SGPLPSSSGS SSSSSQLSVA TLGRSPSPKS 970 980 990 1000 1010 1020 ALLTQNGTGS LPRNLAATLQ DIETKRQLAL QQKGQQVIEE QRRRLAELKQ KAAAEAQCQW 1030 1040 1050 1060 1070 1080 DALHGAAPFP AGPSGFPPLM HHSILHHLPA GRERGEEGEH AYDTLSLESS DSMETSISTG 1090 1100 1110 1120 1130 1140 GNSACSPDNM SSASGLDMGK IEEMEKMLKE AHAEKNRLME SREREMELRR QALEEERRRR 1150 1160 1170 1180 1190 1200 EQVERRLQSE SARRQQLVEK EVKMREKQFS QARPLTRYLP IRKEDFDLKT HIESSGHGVD 1210 1220 1230 1240 1250 1260 TCLHVVLSSK VCRGYLVKMG GKIKSWKKRW FVFDRLKRTL SYYVDKHETK LKGVIYFQAI 1270 1280 1290 1300 1310 EEVYYDHLRS AAKSPNPALT FCVKTHDRLY YMVAPSAEAM RIWMDVIVTG AEGYTQFMN
	Isoform 3 [UniParc]. Checksum: D11D43C8C73BB999	FASTA	995	107,381
	10 20 30 40 50 60 MDALNRNQIG PGCQTQTMVQ KGPLDLIETG KGLKVQTDKP HLVSLGSGRL STAITLLPLE 70 80 90 100 110 120 EGRTVIGSAA RDISLQGPGL APEHCYIENL RGTLTLYPCG NACTIDGLPV RQPTRLTQGC 130 140 150 160 170 180 MLCLGQSTFL RFNHPAEAKW MKSMIPAGGR APGPPYSPVP AESESLVNGN HTPQTATRGP 190 200 210 220 230 240 SACASHSSLV SSIEKDLQEI MDSLVLEEPG AAGKKPAATS PLSPMANGGR YLLSPPTSPG 250 260 270 280 290 300 AMSVGSSYEN TSPAFSPLSS PASSGSCASH SPSGQEPGPS VPPLVPARSS SYHLALQPPQ 310 320 330 340 350 360 SRPSGARSES PRLSRKGGHE RPPSPGLRGL LTDSPAATVL AEARRATESP RLGGQLPVVA 370 380 390 400 410 420 ISLSEYPASG ALSQPTSIPG SPKFQPPVPA PRNKIGTLQD RPPSPFREPP GSERVLTTSP 430 440 450 460 470 480 SRQLVGRTFS DGLATRTLQP PESPRLGRRG LDSMRELPPL SPSLSRRALS PLPTRTTPDP 490 500 510 520 530 540 KLNREVAESP RPRRWAAHGA SPEDFSLTLG ARGRRTRSPS PTLGESLAPH KGSFSGRLSP 550 560 570 580 590 600 AYSLGSLTGA SPCQSPCVQR KLSSGDLRVP VTRERKNSIT EISDNEDDLL EYHRRQRQER 610 620 630 640 650 660 LREQEMERLE RQRLETILNL CAEYSRADGG PEAGELPSIG EATAALALAG RRPSRGLAGA 670 680 690 700 710 720 SGRSSEEPGV ATQRLWESME RSDEENLKEE CSSTESTQQE HEDAPSTKLQ GEVLALEEER 730 740 750 760 770 780 AQVLGHVEQL KVRVKELEQQ LQESAREAEM ERALLQGERE AERALLQKEQ KAVDQLQEKL 790 800 810 820 830 840 VALETGIQKE RDKEAEALET ETKLFEDLEF QQLERESRVE EERELAGQGL LRSKAELLRS 850 860 870 880 890 900 IAKRKERLAI LDSQAGQIRA QAVQESERLA RDKNASLQLL QKEKEKLTVL ERRYHSLTGG 910 920 930 940 950 960 RPFPKTTSTL KEVYRSKMDG EATSPLPRTR SGPLPSSSGS SSSSSQLSVA TLGRSPSPKS 970 980 990 ALLTQNGTGS LPRNLAATLQ DIETKRQLAL QQKGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a 500-kb region of common allelic loss in chromosome 11q23 in non-MYCN amplified type of neuroblastoma." Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T., Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Spleen.
[5]	NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Placenta.
[9]	"Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities." Dowler S.J., Currie R.A., Campbell D.G., Deak M., Kular G., Downes C.P., Alessi D.R. Biochem. J. 351:19-31(2000) [PubMed] [Europe PMC] [Abstract] Cited for: BINDING TO PHOSPHOINOSITIDES.
[10]	"Identification and characterization of human LL5A gene and mouse Ll5a gene in silico." Katoh M., Katoh M. Int. J. Oncol. 23:1477-1483(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220; SER-223; SER-430; SER-443; SER-501; SER-520; SER-551; SER-555 AND SER-583, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520 AND THR-522, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB094090 mRNA. Translation: BAC76044.1. AB014538 mRNA. Translation: BAA31613.2. Different initiation. AK074070 mRNA. Translation: BAB84896.2. Different initiation. EF445008 Genomic DNA. Translation: ACA06043.1. EF445008 Genomic DNA. Translation: ACA06041.1. AP000941 Genomic DNA. No translation available. AP002954 Genomic DNA. No translation available. CH471065 Genomic DNA. Translation: EAW67401.1. BC098586 mRNA. Translation: AAH98586.1.
IPI	IPI00413100. IPI00478789. IPI00657870.
RefSeq	NP_001138230.1. NM_001144758.2. NP_001138231.1. NM_001144759.2. NP_055972.1. NM_015157.3.
UniGene	Hs.504062.
3D structure databases
ProteinModelPortal	Q86UU1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000354498.
PTM databases
PhosphoSite	Q86UU1.
Polymorphism databases
DMDM	74723506.
Proteomic databases
PaxDb	Q86UU1.
PRIDE	Q86UU1.
Protocols and materials databases
DNASU	23187.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356063; ENSP00000348359; ENSG00000019144. ENST00000361417; ENSP00000354498; ENSG00000019144. ENST00000528594; ENSP00000435520; ENSG00000019144. ENST00000530994; ENSP00000431508; ENSG00000019144.
GeneID	23187.
KEGG	hsa:23187.
UCSC	uc001ptr.2. human. uc001ptt.3. human.
Organism-specific databases
CTD	23187.
GeneCards	GC11P118478.
HGNC	HGNC:23697. PHLDB1.
HPA	HPA037959. HPA038448.
MIM	612834. gene.
neXtProt	NX_Q86UU1.
PharmGKB	PA134917952.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86245.
HOGENOM	HOG000286004.
HOVERGEN	HBG080571.
InParanoid	Q86UU1.
OMA	PSACASH.
OrthoDB	EOG4M0F15.
Gene expression databases
ArrayExpress	Q86UU1.
Bgee	Q86UU1.
CleanEx	HS_PHLDB1.
Genevestigator	Q86UU1.
GermOnline	ENSG00000019144. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit. 2.60.200.20. 1 hit.
InterPro	IPR000253. FHA_dom. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR008984. SMAD_FHA_domain. [Graphical view]
Pfam	PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
SUPFAM	SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS50006. FHA_DOMAIN. False negative. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PHLDB1. human.
GenomeRNAi	23187.
NextBio	44659.
SOURCE	Search...

Entry information

Entry name

PHLB1_HUMAN

Accession

Primary (citable) accession number: Q86UU1
Secondary accession number(s): B0YJ63 , B0YJ64, O75133, Q4KMF8, Q8TEQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.