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Protein

B-cell CLL/lymphoma 9-like protein

Gene

BCL9L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).By similarity

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

  • beta-catenin-TCF complex assembly Source: Reactome
  • canonical Wnt signaling pathway Source: Ensembl
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  • positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • regulation of cell morphogenesis Source: BHF-UCL
  • skeletal muscle cell differentiation Source: Ensembl
  • somatic stem cell population maintenance Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 9-like protein
Short name:
B-cell lymphoma 9-like protein
Short name:
BCL9-like protein
Alternative name(s):
Protein BCL9-2
Gene namesi
Name:BCL9L
Synonyms:DLNB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23688. BCL9L.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974002.

Polymorphism and mutation databases

BioMutaiBCL9L.
DMDMi74750433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14991499B-cell CLL/lymphoma 9-like proteinPRO_0000314079Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei25 – 251PhosphoserineCombined sources
Modified residuei36 – 361N6-acetyllysineCombined sources
Modified residuei88 – 881PhosphoserineCombined sources
Modified residuei108 – 1081N6-acetyllysineCombined sources
Modified residuei110 – 1101N6-acetyllysineBy similarity
Modified residuei116 – 1161PhosphoserineCombined sources
Modified residuei118 – 1181PhosphoserineCombined sources
Modified residuei137 – 1371N6-acetyllysineCombined sources
Modified residuei424 – 4241PhosphoserineCombined sources
Modified residuei514 – 5141PhosphothreonineCombined sources
Modified residuei750 – 7501PhosphoserineCombined sources
Modified residuei813 – 8131PhosphoserineCombined sources
Modified residuei915 – 9151PhosphoserineCombined sources
Modified residuei926 – 9261PhosphoserineBy similarity
Modified residuei938 – 9381PhosphoserineCombined sources
Modified residuei942 – 9421PhosphoserineBy similarity
Modified residuei947 – 9471PhosphoserineCombined sources
Modified residuei975 – 9751PhosphoserineCombined sources
Modified residuei987 – 9871PhosphoserineBy similarity
Modified residuei991 – 9911PhosphoserineBy similarity
Modified residuei997 – 9971PhosphoserineCombined sources
Modified residuei1004 – 10041PhosphoserineCombined sources
Modified residuei1010 – 10101PhosphoserineCombined sources
Modified residuei1017 – 10171PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86UU0.
MaxQBiQ86UU0.
PaxDbiQ86UU0.
PeptideAtlasiQ86UU0.
PRIDEiQ86UU0.

PTM databases

iPTMnetiQ86UU0.
PhosphoSiteiQ86UU0.

Expressioni

Tissue specificityi

Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.3 Publications

Gene expression databases

BgeeiENSG00000186174.
CleanExiHS_BCL9L.
ExpressionAtlasiQ86UU0. baseline and differential.
GenevisibleiQ86UU0. HS.

Organism-specific databases

HPAiHPA049370.
HPA053421.

Interactioni

Subunit structurei

Found in a complex with CDC73; CTNNB1 and PYGO1. Interacts with CTNNB1.2 Publications

GO - Molecular functioni

  • beta-catenin binding Source: MGI

Protein-protein interaction databases

BioGridi129475. 7 interactions.
IntActiQ86UU0. 4 interactions.
MINTiMINT-7969417.
STRINGi9606.ENSP00000335320.

Structurei

Secondary structure

1
1499
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi241 – 2433Combined sources
Helixi245 – 25612Combined sources
Beta strandi259 – 2624Combined sources
Helixi263 – 2664Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XB1X-ray1.90A/C237-271[»]
4UP0X-ray1.28A240-268[»]
4UP5X-ray1.65A240-268[»]
ProteinModelPortaliQ86UU0.
SMRiQ86UU0. Positions 240-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni304 – 533230Necessary for interaction with CTNNB1By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 493214Pro-richAdd
BLAST
Compositional biasi689 – 837149Met-richAdd
BLAST
Compositional biasi891 – 1378488Pro-richAdd
BLAST

Domaini

Tne C-terminal domain is important for its transactivation activity.By similarity

Sequence similaritiesi

Belongs to the BCL9 family.Curated

Phylogenomic databases

eggNOGiENOG410IEDB. Eukaryota.
ENOG410XRMX. LUCA.
GeneTreeiENSGT00730000110915.
HOGENOMiHOG000060118.
HOVERGENiHBG031116.
InParanoidiQ86UU0.
OMAiTMRILAN.
OrthoDBiEOG091G00PV.
PhylomeDBiQ86UU0.
TreeFamiTF331144.

Family and domain databases

InterProiIPR015668. Bcl-9.
IPR024670. BCL9_beta-catenin-bd_dom.
[Graphical view]
PANTHERiPTHR15185. PTHR15185. 1 hit.
PfamiPF11502. BCL9. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRILANKTRL PHPRRREAPG SPPLSPRGHC PPAPAKPMHP ENKLTNHGKT
60 70 80 90 100
GNGGAQSQHQ NVNQGPTCNV GSKGVGAGNH GAKANQISPS NSSLKNPQAG
110 120 130 140 150
VPPFSSLKGK VKRDRSVSVD SGEQREAGTP SLDSEAKEVA PRSKRRCVLE
160 170 180 190 200
RKQPYSGDEW CSGPDSEEDD KPIGATHNCN VADPAMAAPQ LGPGQTTQLP
210 220 230 240 250
LSESSVPGAP HGPPPGLRPD APGGGGGGGG VPGKPPSQFV YVFTTHLANT
260 270 280 290 300
AAEAVLQGRA DSILAYHQQN VPRAKLDQAP KVPPTPEPLP LSTPSAGTPQ
310 320 330 340 350
SQPPPLPPPP PPAPGSAPPA LPPEGPPEDS SQDLAPNSVG AASTGGGTGG
360 370 380 390 400
THPNTPTATT ANNPLPPGGD PSSAPGPALL GEAAAPGNGQ RSLVGSEGLS
410 420 430 440 450
KEQLEHRERS LQTLRDIERL LLRSGETEPF LKGPPGGAGE GGPPAQAPPP
460 470 480 490 500
PQQPPTAPPS GLKKYEEPLQ SMISQTQSLG GPPLEHEVPG HPPGGDMGQQ
510 520 530 540 550
MNMMIQRLGQ DSLTPEQVAW RKLQEEYYEE KRRKEEQIGL HGSRPLQDMM
560 570 580 590 600
GMGGMMVRGP PPPYHSKPGD QWPPGMGAQL RGPMDVQDPM QLRGGPPFPG
610 620 630 640 650
PRFPGNQIQR VPGFGGMQSM PMEVPMNAMQ RPVRPGMGWT EDLPPMGGPS
660 670 680 690 700
NFAQNTMPYP GGQGEAERFM TPRVREELLR HQLLEKRSMG MQRPLGMAGS
710 720 730 740 750
GMGQSMEMER MMQAHRQMDP AMFPGQMAGG EGLAGTPMGM EFGGGRGLLS
760 770 780 790 800
PPMGQSGLRE VDPPMGPGNL NMNMNVNMNM NMNLNVQMTP QQQMLMSQKM
810 820 830 840 850
RGPGDLMGPQ GLSPEEMARV RAQNSSGVMG GPQKMLMPSQ FPNQGQQGFS
860 870 880 890 900
GGQGPYQAMS QDMGNTQDMF SPDQSSMPMS NVGTTRLSHM PLPPASNPPG
910 920 930 940 950
TVHSAPNRGL GRRPSDLTIS INQMGSPGMG HLKSPTLSQV HSPLVTSPSA
960 970 980 990 1000
NLKSPQTPSQ MVPLPSANPP GPLKSPQVLG SSLSVRSPTG SPSRLKSPSM
1010 1020 1030 1040 1050
AVPSPGWVAS PKTAMPSPGV SQNKQPPLNM NSSTTLSNME QGTLPPSGPR
1060 1070 1080 1090 1100
SSSSAPPANP PSGLMNPSLP FTSSPDPTPS QNPLSLMMTQ MSKYAMPSST
1110 1120 1130 1140 1150
PLYHNAIKTI ATSDDELLPD RPLLPPPPPP QGSGPGISNS QPSQMHLNSA
1160 1170 1180 1190 1200
AAQSPMGMNL PGQQPLSHEP PPAMLPSPTP LGSNIPLHPN AQGTGGPPQN
1210 1220 1230 1240 1250
SMMMAPGGPD SLNAPCGPVP SSSQMMPFPP RLQQPHGAMA PTGGGGGGPG
1260 1270 1280 1290 1300
LQQHYPSGMA LPPEDLPNQP PGPMPPQQHL MGKAMAGRMG DAYPPGVLPG
1310 1320 1330 1340 1350
VASVLNDPEL SEVIRPTPTG IPEFDLSRII PSEKPSSTLQ YFPKSENQPP
1360 1370 1380 1390 1400
KAQPPNLHLM NLQNMMAEQT PSRPPNLPGQ QGVQRGLNMS MCHPGQMSLL
1410 1420 1430 1440 1450
GRTGVPPQQG MVPHGLHQGV MSPPQGLMTQ QNFMLMKQRG VGGEVYSQPP
1460 1470 1480 1490
HMLSPQGSLM GPPPQQNLMV SHPLRQRSVS LDSQMGYLPA PGGMANLPF
Length:1,499
Mass (Da):157,129
Last modified:June 1, 2003 - v1
Checksum:i8415C2EDB7AA9C0C
GO
Isoform 2 (identifier: Q86UU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-13: Missing.

Show »
Length:1,494
Mass (Da):156,529
Checksum:i2D591F45FF3AEE36
GO
Isoform 3 (identifier: Q86UU0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1333-1394: EKPSSTLQYF...RGLNMSMCHP → WFLRTRPFSF...GLCVCCISVF
     1395-1499: Missing.

Note: No experimental confirmation available.
Show »
Length:1,395
Mass (Da):145,906
Checksum:i521D25B73F563E8E
GO
Isoform 4 (identifier: Q86UU0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1238-1283: Missing.

Note: No experimental confirmation available.
Show »
Length:1,453
Mass (Da):152,547
Checksum:iD325D91BF6C1ED29
GO

Sequence cautioni

The sequence AAH33257 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85500 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85512 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei9 – 135Missing in isoform 2. 1 PublicationVSP_030205
Alternative sequencei1238 – 128346Missing in isoform 4. 1 PublicationVSP_030206Add
BLAST
Alternative sequencei1333 – 139462EKPSS…SMCHP → WFLRTRPFSFCLYLLRILSL LMWLTPLPPLPAGGWPGGQV PAGAVNRALRFCAGLCVCCI SVF in isoform 3. 1 PublicationVSP_030207Add
BLAST
Alternative sequencei1395 – 1499105Missing in isoform 3. 1 PublicationVSP_030208Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296059 mRNA. Translation: AAQ62697.1.
AB094091 mRNA. Translation: BAC76045.1.
CH471065 Genomic DNA. Translation: EAW67418.1.
BC033257 mRNA. Translation: AAH33257.1. Different initiation.
AK122650 mRNA. Translation: BAC85500.1. Different initiation.
AK122882 mRNA. Translation: BAC85512.1. Different initiation.
CCDSiCCDS8403.1. [Q86UU0-1]
RefSeqiNP_872363.1. NM_182557.2. [Q86UU0-1]
XP_005271568.1. XM_005271511.2. [Q86UU0-1]
XP_006718878.1. XM_006718815.2. [Q86UU0-1]
UniGeneiHs.414740.

Genome annotation databases

EnsembliENST00000334801; ENSP00000335320; ENSG00000186174. [Q86UU0-1]
GeneIDi283149.
KEGGihsa:283149.
UCSCiuc001pug.5. human. [Q86UU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296059 mRNA. Translation: AAQ62697.1.
AB094091 mRNA. Translation: BAC76045.1.
CH471065 Genomic DNA. Translation: EAW67418.1.
BC033257 mRNA. Translation: AAH33257.1. Different initiation.
AK122650 mRNA. Translation: BAC85500.1. Different initiation.
AK122882 mRNA. Translation: BAC85512.1. Different initiation.
CCDSiCCDS8403.1. [Q86UU0-1]
RefSeqiNP_872363.1. NM_182557.2. [Q86UU0-1]
XP_005271568.1. XM_005271511.2. [Q86UU0-1]
XP_006718878.1. XM_006718815.2. [Q86UU0-1]
UniGeneiHs.414740.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XB1X-ray1.90A/C237-271[»]
4UP0X-ray1.28A240-268[»]
4UP5X-ray1.65A240-268[»]
ProteinModelPortaliQ86UU0.
SMRiQ86UU0. Positions 240-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129475. 7 interactions.
IntActiQ86UU0. 4 interactions.
MINTiMINT-7969417.
STRINGi9606.ENSP00000335320.

PTM databases

iPTMnetiQ86UU0.
PhosphoSiteiQ86UU0.

Polymorphism and mutation databases

BioMutaiBCL9L.
DMDMi74750433.

Proteomic databases

EPDiQ86UU0.
MaxQBiQ86UU0.
PaxDbiQ86UU0.
PeptideAtlasiQ86UU0.
PRIDEiQ86UU0.

Protocols and materials databases

DNASUi283149.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334801; ENSP00000335320; ENSG00000186174. [Q86UU0-1]
GeneIDi283149.
KEGGihsa:283149.
UCSCiuc001pug.5. human. [Q86UU0-1]

Organism-specific databases

CTDi283149.
GeneCardsiBCL9L.
HGNCiHGNC:23688. BCL9L.
HPAiHPA049370.
HPA053421.
MIMi609004. gene.
neXtProtiNX_Q86UU0.
PharmGKBiPA134974002.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEDB. Eukaryota.
ENOG410XRMX. LUCA.
GeneTreeiENSGT00730000110915.
HOGENOMiHOG000060118.
HOVERGENiHBG031116.
InParanoidiQ86UU0.
OMAiTMRILAN.
OrthoDBiEOG091G00PV.
PhylomeDBiQ86UU0.
TreeFamiTF331144.

Enzyme and pathway databases

ReactomeiR-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-3769402. Deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

ChiTaRSiBCL9L. human.
GenomeRNAii283149.
PROiQ86UU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186174.
CleanExiHS_BCL9L.
ExpressionAtlasiQ86UU0. baseline and differential.
GenevisibleiQ86UU0. HS.

Family and domain databases

InterProiIPR015668. Bcl-9.
IPR024670. BCL9_beta-catenin-bd_dom.
[Graphical view]
PANTHERiPTHR15185. PTHR15185. 1 hit.
PfamiPF11502. BCL9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCL9L_HUMAN
AccessioniPrimary (citable) accession number: Q86UU0
Secondary accession number(s): A1A4C1
, Q67FY1, Q6ZWJ0, Q6ZWK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.