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Protein

NLR family member X1

Gene

NLRX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi166 – 1738ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-168928. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
R-HSA-936440. Negative regulators of RIG-I/MDA5 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
NLR family member X1
Alternative name(s):
Caterpiller protein 11.3
Short name:
CLR11.3
Nucleotide-binding oligomerization domain protein 26
Nucleotide-binding oligomerization domain protein 5
Nucleotide-binding oligomerization domain protein 9
Gene namesi
Name:NLRX1
Synonyms:NOD26, NOD5, NOD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29890. NLRX1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398052.

Polymorphism and mutation databases

BioMutaiNLRX1.
DMDMi74759406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8686MitochondrionAdd
BLAST
Chaini87 – 975889NLR family member X1PRO_0000296190Add
BLAST

Proteomic databases

EPDiQ86UT6.
MaxQBiQ86UT6.
PaxDbiQ86UT6.
PRIDEiQ86UT6.

PTM databases

iPTMnetiQ86UT6.
PhosphoSiteiQ86UT6.

Expressioni

Tissue specificityi

Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).3 Publications

Gene expression databases

BgeeiQ86UT6.
CleanExiHS_NLRX1.
ExpressionAtlasiQ86UT6. baseline and differential.
GenevisibleiQ86UT6. HS.

Organism-specific databases

HPAiHPA038630.

Interactioni

Subunit structurei

Homohexamer. Interacts with MAVS.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Sarm1Q6PDS32EBI-3893071,EBI-6117196From a different organism.

Protein-protein interaction databases

BioGridi122796. 27 interactions.
DIPiDIP-60637N.
IntActiQ86UT6. 9 interactions.
MINTiMINT-4995266.
STRINGi9606.ENSP00000292199.

Structurei

Secondary structure

1
975
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi672 – 68615Combined sources
Helixi688 – 6958Combined sources
Beta strandi700 – 7023Combined sources
Helixi710 – 72011Combined sources
Beta strandi727 – 7315Combined sources
Helixi739 – 7446Combined sources
Helixi746 – 7505Combined sources
Beta strandi752 – 7565Combined sources
Helixi764 – 77512Combined sources
Beta strandi783 – 7853Combined sources
Helixi792 – 80413Combined sources
Beta strandi811 – 8133Combined sources
Helixi820 – 83011Combined sources
Helixi831 – 8333Combined sources
Beta strandi839 – 8413Combined sources
Helixi849 – 86113Combined sources
Beta strandi867 – 8693Combined sources
Helixi877 – 8859Combined sources
Beta strandi895 – 8973Combined sources
Helixi907 – 92014Combined sources
Helixi926 – 94520Combined sources
Helixi950 – 96920Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UN9X-ray2.65A/B/C629-975[»]
ProteinModelPortaliQ86UT6.
SMRiQ86UT6. Positions 157-182, 667-970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 483324NACHTPROSITE-ProRule annotationAdd
BLAST
Domaini667 – 69428LRRNTAdd
BLAST
Repeati695 – 71824LRR 11 PublicationAdd
BLAST
Repeati724 – 74724LRR 21 PublicationAdd
BLAST
Repeati749 – 77729LRR 31 PublicationAdd
BLAST
Repeati778 – 80124LRR 41 PublicationAdd
BLAST
Repeati811 – 83424LRR 51 PublicationAdd
BLAST
Repeati835 – 85723LRR 61 PublicationAdd
BLAST
Repeati858 – 87720LRR 71 PublicationAdd
BLAST
Repeati878 – 89922LRR 81 PublicationAdd
BLAST
Domaini906 – 97065LRRCTAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 556482Required for interaction with MAVSAdd
BLAST
Regioni556 – 974419Required for the repression of MAVS-induced interferon signalingAdd
BLAST

Domaini

The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129829.
HOVERGENiHBG106320.
InParanoidiQ86UT6.
KOiK12653.
OMAiFTVPAMQ.
OrthoDBiEOG7P5T07.
PhylomeDBiQ86UT6.
TreeFamiTF331068.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRWGHHLPRA SWGSGFRRAL QRPDDRIPFL IHWSWPLQGE RPFGPPRAFI
60 70 80 90 100
RHHGSSVDSA PPPGRHGRLF PSASATEAIQ RHRRNLAEWF SRLPREERQF
110 120 130 140 150
GPTFALDTVH VDPVIRESTP DELLRPPAEL ALEHQPPQAG LPPLALSQLF
160 170 180 190 200
NPDACGRRVQ TVVLYGTVGT GKSTLVRKMV LDWCYGRLPA FELLIPFSCE
210 220 230 240 250
DLSSLGPAPA SLCQLVAQRY TPLKEVLPLM AAAGSHLLFV LHGLEHLNLD
260 270 280 290 300
FRLAGTGLCS DPEEPQEPAA IIVNLLRKYM LPQASILVTT RPSAIGRIPS
310 320 330 340 350
KYVGRYGEIC GFSDTNLQKL YFQLRLNQPY CGYAVGGSGV SATPAQRDHL
360 370 380 390 400
VQMLSRNLEG HHQIAAACFL PSYCWLVCAT LHFLHAPTPA GQTLTSIYTS
410 420 430 440 450
FLRLNFSGET LDSTDPSNLS LMAYAARTMG KLAYEGVSSR KTYFSEEDVC
460 470 480 490 500
GCLEAGIRTE EEFQLLHIFR RDALRFFLAP CVEPGRAGTF VFTVPAMQEY
510 520 530 540 550
LAALYIVLGL RKTTLQKVGK EVAELVGRVG EDVSLVLGIM AKLLPLRALP
560 570 580 590 600
LLFNLIKVVP RVFGRMVGKS REAVAQAMVL EMFREEDYYN DDVLDQMGAS
610 620 630 640 650
ILGVEGPRRH PDEPPEDEVF ELFPMFMGGL LSAHNRAVLA QLGCPIKNLD
660 670 680 690 700
ALENAQAIKK KLGKLGRQVL PPSELLDHLF FHYEFQNQRF SAEVLSSLRQ
710 720 730 740 750
LNLAGVRMTP VKCTVVAAVL GSGRHALDEV NLASCQLDPA GLRTLLPVFL
760 770 780 790 800
RARKLGLQLN SLGPEACKDL RDLLLHDQCQ ITTLRLSNNP LTAAGVAVLM
810 820 830 840 850
EGLAGNTSVT HLSLLHTGLG DEGLELLAAQ LDRNRQLQEL NVAYNGAGDT
860 870 880 890 900
AALALARAAR EHPSLELLHL YFNELSSEGR QVLRDLGGAA EGGARVVVSL
910 920 930 940 950
TEGTAVSEYW SVILSEVQRN LNSWDRARVQ RHLELLLRDL EDSRGATLNP
960 970
WRKAQLLRVE GEVRALLEQL GSSGS
Length:975
Mass (Da):107,616
Last modified:June 1, 2003 - v1
Checksum:i25B6624FC13217FF
GO
Isoform 2 (identifier: Q86UT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     869-921: HLYFNELSSE...VILSEVQRNL → QGVAIQMCWK...GLVAPRGRCT
     922-975: Missing.

Note: No experimental confirmation available.
Show »
Length:921
Mass (Da):101,876
Checksum:i1F67611ADB9FAA36
GO

Sequence cautioni

The sequence BAB15075.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAG51714.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG51714.1 differs from that shown. Reason: Erroneous termination at position 951. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti325 – 3251R → C in BAG53014 (PubMed:14702039).Curated
Sequence conflicti575 – 5751A → T in BAG51714 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631P → S.2 Publications
Corresponds to variant rs643423 [ dbSNP | Ensembl ].
VAR_034614
Natural varianti125 – 1251R → L.
Corresponds to variant rs3809045 [ dbSNP | Ensembl ].
VAR_034615
Natural varianti793 – 7931A → E.3 Publications
Corresponds to variant rs4245191 [ dbSNP | Ensembl ].
VAR_034616
Natural varianti843 – 8431A → S.
Corresponds to variant rs35500631 [ dbSNP | Ensembl ].
VAR_034617

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei869 – 92153HLYFN…VQRNL → QGVAIQMCWKLPLLPYAHLW TPRMPSHWCFLLILMPPLPQ WYDGLVAPRGRCT in isoform 2. 1 PublicationVSP_027158Add
BLAST
Alternative sequencei922 – 97554Missing in isoform 2. 1 PublicationVSP_027159Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY245437 mRNA. Translation: AAP31240.1.
BK001111 mRNA. Translation: DAA01244.1.
EF452237 mRNA. Translation: ABO40480.1.
AB094095 mRNA. Translation: BAC76049.1.
AK025131 mRNA. Translation: BAB15075.1. Different initiation.
AK056454 mRNA. Translation: BAG51714.1. Sequence problems.
AK095247 mRNA. Translation: BAG53014.1.
AK291716 mRNA. Translation: BAF84405.1.
BC013199 mRNA. Translation: AAH13199.3.
BC110890 mRNA. Translation: AAI10891.1.
CCDSiCCDS8416.1. [Q86UT6-1]
RefSeqiNP_001269072.1. NM_001282143.1. [Q86UT6-1]
NP_001269073.1. NM_001282144.1. [Q86UT6-1]
NP_001269287.1. NM_001282358.1. [Q86UT6-1]
NP_078894.2. NM_024618.3. [Q86UT6-1]
XP_005271726.1. XM_005271669.1. [Q86UT6-1]
XP_006718967.1. XM_006718904.1. [Q86UT6-2]
XP_011541282.1. XM_011542980.1. [Q86UT6-1]
UniGeneiHs.524082.

Genome annotation databases

EnsembliENST00000292199; ENSP00000292199; ENSG00000160703. [Q86UT6-1]
ENST00000409109; ENSP00000387334; ENSG00000160703. [Q86UT6-1]
ENST00000409265; ENSP00000386858; ENSG00000160703. [Q86UT6-1]
ENST00000409991; ENSP00000386851; ENSG00000160703. [Q86UT6-1]
ENST00000525863; ENSP00000433442; ENSG00000160703. [Q86UT6-2]
GeneIDi79671.
KEGGihsa:79671.
UCSCiuc001pvu.5. human. [Q86UT6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY245437 mRNA. Translation: AAP31240.1.
BK001111 mRNA. Translation: DAA01244.1.
EF452237 mRNA. Translation: ABO40480.1.
AB094095 mRNA. Translation: BAC76049.1.
AK025131 mRNA. Translation: BAB15075.1. Different initiation.
AK056454 mRNA. Translation: BAG51714.1. Sequence problems.
AK095247 mRNA. Translation: BAG53014.1.
AK291716 mRNA. Translation: BAF84405.1.
BC013199 mRNA. Translation: AAH13199.3.
BC110890 mRNA. Translation: AAI10891.1.
CCDSiCCDS8416.1. [Q86UT6-1]
RefSeqiNP_001269072.1. NM_001282143.1. [Q86UT6-1]
NP_001269073.1. NM_001282144.1. [Q86UT6-1]
NP_001269287.1. NM_001282358.1. [Q86UT6-1]
NP_078894.2. NM_024618.3. [Q86UT6-1]
XP_005271726.1. XM_005271669.1. [Q86UT6-1]
XP_006718967.1. XM_006718904.1. [Q86UT6-2]
XP_011541282.1. XM_011542980.1. [Q86UT6-1]
UniGeneiHs.524082.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UN9X-ray2.65A/B/C629-975[»]
ProteinModelPortaliQ86UT6.
SMRiQ86UT6. Positions 157-182, 667-970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122796. 27 interactions.
DIPiDIP-60637N.
IntActiQ86UT6. 9 interactions.
MINTiMINT-4995266.
STRINGi9606.ENSP00000292199.

PTM databases

iPTMnetiQ86UT6.
PhosphoSiteiQ86UT6.

Polymorphism and mutation databases

BioMutaiNLRX1.
DMDMi74759406.

Proteomic databases

EPDiQ86UT6.
MaxQBiQ86UT6.
PaxDbiQ86UT6.
PRIDEiQ86UT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292199; ENSP00000292199; ENSG00000160703. [Q86UT6-1]
ENST00000409109; ENSP00000387334; ENSG00000160703. [Q86UT6-1]
ENST00000409265; ENSP00000386858; ENSG00000160703. [Q86UT6-1]
ENST00000409991; ENSP00000386851; ENSG00000160703. [Q86UT6-1]
ENST00000525863; ENSP00000433442; ENSG00000160703. [Q86UT6-2]
GeneIDi79671.
KEGGihsa:79671.
UCSCiuc001pvu.5. human. [Q86UT6-1]

Organism-specific databases

CTDi79671.
GeneCardsiNLRX1.
H-InvDBHIX0010285.
HGNCiHGNC:29890. NLRX1.
HPAiHPA038630.
MIMi611947. gene.
neXtProtiNX_Q86UT6.
PharmGKBiPA162398052.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129829.
HOVERGENiHBG106320.
InParanoidiQ86UT6.
KOiK12653.
OMAiFTVPAMQ.
OrthoDBiEOG7P5T07.
PhylomeDBiQ86UT6.
TreeFamiTF331068.

Enzyme and pathway databases

ReactomeiR-HSA-168928. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
R-HSA-936440. Negative regulators of RIG-I/MDA5 signaling.

Miscellaneous databases

ChiTaRSiNLRX1. human.
GeneWikiiNLRX1.
GenomeRNAii79671.
NextBioi68897.
PROiQ86UT6.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UT6.
CleanExiHS_NLRX1.
ExpressionAtlasiQ86UT6. baseline and differential.
GenevisibleiQ86UT6. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NODs: intracellular proteins involved in inflammation and apoptosis."
    Inohara N., Nunez G.
    Nat. Rev. Immunol. 3:371-382(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-63 AND GLU-793.
  2. Kronos K.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Identification of a 500-kb region of common allelic loss in chromosome 11q23 in non-MYCN amplified type of neuroblastoma."
    Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T., Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-63 AND GLU-793.
    Tissue: Colon, Placenta and Tongue.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 214-975 (ISOFORM 2), VARIANT GLU-793.
    Tissue: Bone and Brain.
  6. "NOD-LRR proteins: role in host-microbial interactions and inflammatory disease."
    Inohara N., Chamaillard M., McDonald C., Nunez G.
    Annu. Rev. Biochem. 74:355-383(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "CATERPILLER: a novel gene family important in immunity, cell death, and diseases."
    Ting J.P.-Y., Davis B.K.
    Annu. Rev. Immunol. 23:387-414(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production."
    Tattoli I., Carneiro L.A., Jehanno M., Magalhaes J.G., Shu Y., Philpott D.J., Arnoult D., Girardin S.E.
    EMBO Rep. 9:293-300(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. Cited for: FUNCTION, INTERACTION WITH MAVS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. "Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator."
    Hong M., Yoon S.I., Wilson I.A.
    Immunity 36:337-347(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 629-975, LRR REPEATS, SUBUNIT.

Entry informationi

Entry nameiNLRX1_HUMAN
AccessioniPrimary (citable) accession number: Q86UT6
Secondary accession number(s): A8K6Q1
, B3KPK2, B3KTA2, Q7RTR3, Q96D51, Q9H724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.