##gff-version 3 Q86US8 UniProtKB Chain 1 1419 . . . ID=PRO_0000087069;Note=Telomerase-binding protein EST1A Q86US8 UniProtKB Domain 1246 1397 . . . Note=PINc Q86US8 UniProtKB Region 25 79 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Region 39 59 . . . Note=EJC-binding motif 1%3B mediates interaction with the EJC Q86US8 UniProtKB Region 99 165 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Region 114 503 . . . Note=Interaction with telomeric DNA Q86US8 UniProtKB Region 133 153 . . . Note=EJC-binding motif 2%3B mediates interaction with the EJC Q86US8 UniProtKB Region 177 405 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Region 419 472 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Region 854 883 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Coiled coil 163 193 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86US8 UniProtKB Coiled coil 567 625 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86US8 UniProtKB Coiled coil 1197 1239 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86US8 UniProtKB Compositional bias 30 79 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Compositional bias 99 125 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Compositional bias 129 144 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Compositional bias 177 203 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Compositional bias 212 245 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Compositional bias 257 272 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Compositional bias 275 345 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Compositional bias 364 402 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Compositional bias 861 883 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86US8 UniProtKB Binding site 1251 1251 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86US8 UniProtKB Binding site 1353 1353 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86US8 UniProtKB Binding site 1392 1392 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86US8 UniProtKB Modified residue 203 203 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86US8 UniProtKB Modified residue 332 332 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P61406 Q86US8 UniProtKB Modified residue 406 406 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P61406 Q86US8 UniProtKB Modified residue 433 433 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P61406 Q86US8 UniProtKB Modified residue 471 471 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P61406 Q86US8 UniProtKB Modified residue 479 479 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163 Q86US8 UniProtKB Modified residue 484 484 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86US8 UniProtKB Modified residue 831 831 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86US8 UniProtKB Modified residue 870 870 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86US8 UniProtKB Modified residue 874 874 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86US8 UniProtKB Alternative sequence 1 1089 . . . ID=VSP_010360;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q86US8 UniProtKB Alternative sequence 1 908 . . . ID=VSP_047157;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q86US8 UniProtKB Alternative sequence 1090 1119 . . . ID=VSP_010361;Note=In isoform 2. ILEEDRLLSGFVPLLAAPQDPCYVEKTSDK->MRFRLCHQRGCCPHERENTCTCKMIISSLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q86US8 UniProtKB Natural variant 291 291 . . . ID=VAR_018499;Note=R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9872452;Dbxref=dbSNP:rs1885986,PMID:9872452 Q86US8 UniProtKB Natural variant 294 294 . . . ID=VAR_018500;Note=K->Q;Dbxref=dbSNP:rs216195 Q86US8 UniProtKB Natural variant 341 341 . . . ID=VAR_018501;Note=N->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676087,ECO:0000269|PubMed:9872452;Dbxref=dbSNP:rs1885987,PMID:12676087,PMID:9872452 Q86US8 UniProtKB Natural variant 575 575 . . . ID=VAR_050978;Note=N->S;Dbxref=dbSNP:rs34047637 Q86US8 UniProtKB Natural variant 972 972 . . . ID=VAR_018502;Note=A->T;Dbxref=dbSNP:rs903160 Q86US8 UniProtKB Natural variant 984 984 . . . ID=VAR_050979;Note=R->C;Dbxref=dbSNP:rs35173108 Q86US8 UniProtKB Natural variant 1189 1189 . . . ID=VAR_061648;Note=E->K;Dbxref=dbSNP:rs58801957 Q86US8 UniProtKB Natural variant 1233 1233 . . . ID=VAR_018503;Note=H->R;Dbxref=dbSNP:rs2273980 Q86US8 UniProtKB Mutagenesis 46 52 . . . Note=Alters interaction with the EJC. Loss of interaction with the EJC%3B when associated with 140-E--E-146. RPDLEIY->EPDLEIE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20930030;Dbxref=PMID:20930030 Q86US8 UniProtKB Mutagenesis 140 146 . . . Note=Alters interaction with the EJC. Loss of interaction with the EJC%3B when associated with 46-E--E-52. KPDLQIY->EPDLQIE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20930030;Dbxref=PMID:20930030 Q86US8 UniProtKB Mutagenesis 1251 1251 . . . Note=Impaired nonsense-mediated RNA decay. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18974281,ECO:0000269|PubMed:19060897;Dbxref=PMID:18974281,PMID:19060897 Q86US8 UniProtKB Mutagenesis 1251 1251 . . . Note=Loss of endonuclease activity and nonsense-mediated RNA decay%3B when associated with N-1392. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18974281,ECO:0000269|PubMed:19060897;Dbxref=PMID:18974281,PMID:19060897 Q86US8 UniProtKB Mutagenesis 1353 1353 . . . Note=Abolishes RNase activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17053788,ECO:0000269|PubMed:19060897;Dbxref=PMID:17053788,PMID:19060897 Q86US8 UniProtKB Mutagenesis 1392 1392 . . . Note=Impaired nonsense-mediated RNA decay%3B when associated with A-1251. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18974281,ECO:0000269|PubMed:19060897;Dbxref=PMID:18974281,PMID:19060897 Q86US8 UniProtKB Mutagenesis 1392 1392 . . . Note=Loss of endonuclease activity and nonsense-mediated RNA decay%3B when associated with N-1251. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18974281,ECO:0000269|PubMed:19060897;Dbxref=PMID:18974281,PMID:19060897 Q86US8 UniProtKB Helix 580 600 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 601 603 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 606 629 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 631 636 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 639 647 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 649 660 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 667 696 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 700 703 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 716 742 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 749 761 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 767 778 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 782 793 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 795 797 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 801 820 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 880 882 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 885 905 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 909 911 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 912 928 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 929 931 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 936 951 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 966 992 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1001 1003 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1006 1008 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1012 1014 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1017 1020 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1023 1035 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1037 1039 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1057 1068 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 1079 1081 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 1086 1088 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1092 1097 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1101 1105 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 1112 1114 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Helix 1119 1139 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 1140 1143 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 1145 1149 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 1152 1155 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UM2 Q86US8 UniProtKB Beta strand 1240 1250 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Helix 1252 1268 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Beta strand 1270 1276 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Helix 1277 1287 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Helix 1298 1319 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Beta strand 1325 1328 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Beta strand 1334 1336 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Helix 1352 1361 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Helix 1368 1371 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Beta strand 1381 1389 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Helix 1393 1401 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK Q86US8 UniProtKB Helix 1409 1416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DOK