Q86UR5 (RIMS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulating synaptic membrane exocytosis protein 1

Alternative name(s):
Rab-3-interacting molecule 1
Short name=RIM 1
Rab-3-interacting protein 2

Gene names

Name:	RIMS1
Synonyms:	KIAA0340, RAB3IP2, RIM1
ORF Names:	Nbla00761

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1692 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity By similarity.
Subunit structure	Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Interacts with RAB3C, RAB10, RAB26 AND RAB37. Binds UNC13A. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts with ERC1 By similarity. Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions. Ref.7
Subcellular location	Cell membrane; Peripheral membrane protein By similarity. Cell junction › synapse By similarity. Cell junction › synapse › presynaptic cell membrane; Peripheral membrane protein By similarity.
Tissue specificity	Detected in brain and retina.
Post-translational modification	Phosphorylated by BRSK1 By similarity.
Involvement in disease	Cone-rod dystrophy 7 (CORD7) [MIM:603649]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Note: The disease may be caused by mutations affecting the gene represented in this entry. Ref.1
Sequence similarities	Contains 2 C2 domains. Contains 1 FYVE-type zinc finger. Contains 1 PDZ (DHR) domain. Contains 1 RabBD (Rab-binding) domain.
Sequence caution	The sequence BAA20798.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI39600.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI42135.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Exocytosis Neurotransmitter transport Sensory transduction Transport Vision
Cellular component	Cell junction Cell membrane Membrane Synapse
Coding sequence diversity	Alternative splicing
Disease	Cone-rod dystrophy Disease mutation
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium ion-dependent exocytosis Traceable author statement Ref.7. Source: UniProtKB calcium ion-dependent exocytosis of neurotransmitter Inferred from electronic annotation. Source: Compara cellular membrane fusion Non-traceable author statement Ref.7. Source: UniProtKB glutamate secretion Traceable author statement. Source: Reactome intracellular protein transport Inferred from electronic annotation. Source: InterPro protein complex assembly Inferred from direct assay Ref.7. Source: UniProtKB regulated secretory pathway Non-traceable author statement Ref.7. Source: UniProtKB regulation of long-term neuronal synaptic plasticity Inferred from electronic annotation. Source: Compara regulation of membrane potential Inferred from electronic annotation. Source: Compara response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle exocytosis Traceable author statement Ref.7. Source: UniProtKB visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome presynaptic membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW small GTPase regulator activity Traceable author statement Ref.7. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	2	EBI-1043236,EBI-375543

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q86UR5-1)

Also known as: RIM1 alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86UR5-2)

Also known as: RIM short form;

The sequence of this isoform differs from the canonical sequence as follows:
     1040-1692: Missing.

Note: May be due to intron retention.

Isoform 3 (identifier: Q86UR5-3)

Also known as: RIM long form; Rab3 interacting protein variant 2;

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1102: Missing.
     1133-1245: Missing.
     1540-1573: Missing.

Isoform 4 (identifier: Q86UR5-4)

Also known as: Rab3 interacting protein variant 1;

The sequence of this isoform differs from the canonical sequence as follows:
     1065-1102: Missing.
     1133-1245: Missing.

Isoform 5 (identifier: Q86UR5-5)

Also known as: Rab3 interacting protein variant 3;

The sequence of this isoform differs from the canonical sequence as follows:
     924-924: Missing.
     1038-1244: Missing.
     1377-1385: Missing.

Isoform 6 (identifier: Q86UR5-6)

Also known as: Rab3 interacting protein variant 4;

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1102: Missing.
     1161-1245: Missing.
     1284-1455: Missing.

Isoform 7 (identifier: Q86UR5-7)

Also known as: Rab3 interacting protein variant 5;

The sequence of this isoform differs from the canonical sequence as follows:
     924-924: Missing.
     1039-1102: Missing.
     1133-1245: Missing.
     1284-1455: Missing.

Isoform 8 (identifier: Q86UR5-8)

Also known as: Rab3 interacting protein variant 6;

The sequence of this isoform differs from the canonical sequence as follows:
     924-924: Missing.
     1018-1245: Missing.
     1284-1455: Missing.

Isoform 9 (identifier: Q86UR5-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSSAVGPRGPRPPTVPPP → MFAGFLQFLLLHTLHSGT
     19-559: Missing.
     1039-1102: Missing.
     1133-1160: Missing.
     1185-1245: Missing.
     1284-1455: Missing.

Note: No experimental confirmation available.

Isoform 10 (identifier: Q86UR5-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-607: Missing.
     1039-1102: Missing.
     1133-1160: Missing.
     1185-1245: Missing.
     1284-1455: Missing.

Note: No experimental confirmation available.

Isoform 11 (identifier: Q86UR5-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1473: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1692

1692

Regulating synaptic membrane exocytosis protein 1

PRO_0000190198

Regions

Domain

22 – 182

161

RabBD

Domain

605 – 691

87

PDZ

Domain

744 – 850

107

C2 1

Domain

1538 – 1640

103

C2 2

Zinc finger

110 – 170

61

FYVE-type

Compositional bias

1336 – 1402

67

Ser-rich

Amino acid modifications

Modified residue

324

1

Phosphoserine By similarity

Modified residue

881

1

Phosphoserine By similarity

Modified residue

977

1

Phosphoserine By similarity

Modified residue

1252

1

Phosphoserine By similarity

Modified residue

1254

1

Phosphothreonine By similarity

Modified residue

1256

1

Phosphoserine By similarity

Modified residue

1677

1

Phosphoserine Ref.9

Modified residue

1680

1

Phosphoserine Ref.9

Modified residue

1683

1

Phosphoserine Ref.9

Modified residue

1692

1

Phosphoserine Ref.9

Natural variations

Alternative sequence

1 – 1473

1473

Missing in isoform 11.

VSP_045485

Alternative sequence

1 – 607

607

Missing in isoform 10.

VSP_045486

Alternative sequence

1 – 18

18

MSSAV…TVPPP → MFAGFLQFLLLHTLHSGT in isoform 9.

VSP_043177

Alternative sequence

19 – 559

541

Missing in isoform 9.

VSP_043178

Alternative sequence

924

1

Missing in isoform 5, isoform 7 and isoform 8.

VSP_008161

Alternative sequence

1018 – 1245

228

Missing in isoform 8.

VSP_008162

Alternative sequence

1038 – 1244

207

Missing in isoform 5.

VSP_008163

Alternative sequence

1039 – 1102

64

Missing in isoform 3, isoform 6, isoform 7, isoform 9 and isoform 10.

VSP_008164

Alternative sequence

1040 – 1692

653

Missing in isoform 2.

VSP_008165

Alternative sequence

1065 – 1102

38

Missing in isoform 4.

VSP_008166

Alternative sequence

1133 – 1245

113

Missing in isoform 3, isoform 4 and isoform 7.

VSP_008167

Alternative sequence

1133 – 1160

28

Missing in isoform 9 and isoform 10.

VSP_043179

Alternative sequence

1161 – 1245

85

Missing in isoform 6.

VSP_008168

Alternative sequence

1185 – 1245

61

Missing in isoform 9 and isoform 10.

VSP_043180

Alternative sequence

1284 – 1455

172

Missing in isoform 6, isoform 7, isoform 8, isoform 9 and isoform 10.

VSP_008169

Alternative sequence

1377 – 1385

9

Missing in isoform 5.

VSP_008170

Alternative sequence

1540 – 1573

34

Missing in isoform 3.

VSP_008171

Natural variant

820

1

R → H in CORD7. Ref.1

VAR_016804

Experimental info

Mutagenesis

796 – 797

2

RR → AA: Abolishes interaction with SYT1 and CACNA1B. Ref.7

Mutagenesis

1591 – 1592

2

KK → AA: Abolishes interaction with SYT1 and CACNA1B. Ref.7

Sequence conflict

157

1

V → Y in CAI16961. Ref.5

Sequence conflict

484 – 494

11

Missing in BAB87121. Ref.2

Sequence conflict

484 – 494

11

Missing in BAB87242. Ref.2

Sequence conflict

484 – 494

11

Missing in BAA20798. Ref.3

Sequence conflict

484 – 494

11

Missing in AAI51854. Ref.6

Sequence conflict

484 – 494

11

Missing in AAI52436. Ref.6

Sequence conflict

1609

1

V → A in BAH13358. Ref.4

Sequence conflict

1662

1

S → P in AK309185. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1692

Helix Strand Turn

Details...

Beta strand

585 – 589

5

Beta strand

591 – 602

12

Beta strand

609 – 611

3

Beta strand

616 – 625

10

Beta strand

629 – 638

10

Helix

643 – 646

4

Beta strand

655 – 661

7

Helix

669 – 678

10

Helix

679 – 681

3

Beta strand

685 – 691

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (RIM1 alpha) [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0A96642DC832C15E	FASTA	1,692	189,073
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 1040 1050 1060 1070 1080 LMLPRAKRGR SAECLHTTRH LVRHYKTLPP KMPLLQSSSH WNIYSSILPA HTKTKSVTRQ 1090 1100 1110 1120 1130 1140 DISLHHECFN STVLRFTDEI LVSELQPFLD RARSASTNCL RPDTSLHSPE RERGRWSPSL 1150 1160 1170 1180 1190 1200 DRRRPPSPRI QIQHASPEND RHSRKSERSS IQKQTRKGTA SDAERVLPTC LSRRGHAAPR 1210 1220 1230 1240 1250 1260 ATDQPVIRGK HPARSRSSEH SSIRTLCSMH HLVPGGSAPP SPLLTRMHRQ RSPTQSPPAD 1270 1280 1290 1300 1310 1320 TSFSSRRGRQ LPQVPVRSGS IEQASLVVEE RTRQMKMKVH RFKQTTGSGS SQELDREQYS 1330 1340 1350 1360 1370 1380 KYNIHKDQYR SCDNVSAKSS DSDVSDVSAI SRTSSASRLS STSFMSEQSE RPRGRISSFT 1390 1400 1410 1420 1430 1440 PKMQGRRMGT SGRSIMKSTS VSGEMYTLEH NDGSQSDTAV GTVGAGGKKR RSSLSAKVVA 1450 1460 1470 1480 1490 1500 IVSRRSRSTS QLSQTESGHK KLKSTIQRST ETGMAAEMRK MVRQPSREST DGSINSYSSE 1510 1520 1530 1540 1550 1560 GNLIFPGVRL GADSQFSDFL DGLGPAQLVG RQTLATPAMG DIQIGMEDKK GQLEVEVIRA 1570 1580 1590 1600 1610 1620 RSLTQKPGSK STPAPYVKVY LLENGACIAK KKTRIARKTL DPLYQQSLVF DESPQGKVLQ 1630 1640 1650 1660 1670 1680 VIVWGDYGRM DHKCFMGVAQ ILLEELDLSS MVIGWYKLFP PSSLVDPTLT PLTRRASQSS 1690 LESSTGPPCI RS
	Isoform 2 (RIM short form) [UniParc]. Checksum: EF56FBC20E5A629E	FASTA	1,039	116,704
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 LMLPRAKRGR SAECLHTTR
	Isoform 3 (RIM long form) (Rab3 interacting protein variant 2) [UniParc]. Checksum: F34E4B8FAF1D35FD	FASTA	1,481	165,360
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 1040 1050 1060 1070 1080 LMLPRAKRGR SAECLHTTSE LQPFLDRARS ASTNCLRPDT SLHSPERERM HRQRSPTQSP 1090 1100 1110 1120 1130 1140 PADTSFSSRR GRQLPQVPVR SGSIEQASLV VEERTRQMKM KVHRFKQTTG SGSSQELDRE 1150 1160 1170 1180 1190 1200 QYSKYNIHKD QYRSCDNVSA KSSDSDVSDV SAISRTSSAS RLSSTSFMSE QSERPRGRIS 1210 1220 1230 1240 1250 1260 SFTPKMQGRR MGTSGRSIMK STSVSGEMYT LEHNDGSQSD TAVGTVGAGG KKRRSSLSAK 1270 1280 1290 1300 1310 1320 VVAIVSRRSR STSQLSQTES GHKKLKSTIQ RSTETGMAAE MRKMVRQPSR ESTDGSINSY 1330 1340 1350 1360 1370 1380 SSEGNLIFPG VRLGADSQFS DFLDGLGPAQ LVGRQTLATP AMAPYVKVYL LENGACIAKK 1390 1400 1410 1420 1430 1440 KTRIARKTLD PLYQQSLVFD ESPQGKVLQV IVWGDYGRMD HKCFMGVAQI LLEELDLSSM 1450 1460 1470 1480 VIGWYKLFPP SSLVDPTLTP LTRRASQSSL ESSTGPPCIR S
	Isoform 4 (Rab3 interacting protein variant 1) [UniParc]. Checksum: 98A7006DC8206CB3	FASTA	1,541	172,224
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 1040 1050 1060 1070 1080 LMLPRAKRGR SAECLHTTRH LVRHYKTLPP KMPLLQSSSH WNIYSELQPF LDRARSASTN 1090 1100 1110 1120 1130 1140 CLRPDTSLHS PERERMHRQR SPTQSPPADT SFSSRRGRQL PQVPVRSGSI EQASLVVEER 1150 1160 1170 1180 1190 1200 TRQMKMKVHR FKQTTGSGSS QELDREQYSK YNIHKDQYRS CDNVSAKSSD SDVSDVSAIS 1210 1220 1230 1240 1250 1260 RTSSASRLSS TSFMSEQSER PRGRISSFTP KMQGRRMGTS GRSIMKSTSV SGEMYTLEHN 1270 1280 1290 1300 1310 1320 DGSQSDTAVG TVGAGGKKRR SSLSAKVVAI VSRRSRSTSQ LSQTESGHKK LKSTIQRSTE 1330 1340 1350 1360 1370 1380 TGMAAEMRKM VRQPSRESTD GSINSYSSEG NLIFPGVRLG ADSQFSDFLD GLGPAQLVGR 1390 1400 1410 1420 1430 1440 QTLATPAMGD IQIGMEDKKG QLEVEVIRAR SLTQKPGSKS TPAPYVKVYL LENGACIAKK 1450 1460 1470 1480 1490 1500 KTRIARKTLD PLYQQSLVFD ESPQGKVLQV IVWGDYGRMD HKCFMGVAQI LLEELDLSSM 1510 1520 1530 1540 VIGWYKLFPP SSLVDPTLTP LTRRASQSSL ESSTGPPCIR S
	Isoform 5 (Rab3 interacting protein variant 3) [UniParc]. Checksum: 8192B1AF38A1661B	FASTA	1,475	164,580
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPGYRSSAR ESKSTTLTVP EQQRTTHHRS RSVSPHRGND 970 980 990 1000 1010 1020 QGKPRSRLPN VPLQRSLDEI HPTRRSRSPT RHHDASRSPV DHRTRDVDSQ YLSEQDSELL 1030 1040 1050 1060 1070 1080 MLPRAKRGRS AECLHTTRMH RQRSPTQSPP ADTSFSSRRG RQLPQVPVRS GSIEQASLVV 1090 1100 1110 1120 1130 1140 EERTRQMKMK VHRFKQTTGS GSSQELDREQ YSKYNIHKDQ YRSCDNVSAK SSDSDVSDVS 1150 1160 1170 1180 1190 1200 AISRTSSASR LSSTSFMSEQ SERPRGRIRR MGTSGRSIMK STSVSGEMYT LEHNDGSQSD 1210 1220 1230 1240 1250 1260 TAVGTVGAGG KKRRSSLSAK VVAIVSRRSR STSQLSQTES GHKKLKSTIQ RSTETGMAAE 1270 1280 1290 1300 1310 1320 MRKMVRQPSR ESTDGSINSY SSEGNLIFPG VRLGADSQFS DFLDGLGPAQ LVGRQTLATP 1330 1340 1350 1360 1370 1380 AMGDIQIGME DKKGQLEVEV IRARSLTQKP GSKSTPAPYV KVYLLENGAC IAKKKTRIAR 1390 1400 1410 1420 1430 1440 KTLDPLYQQS LVFDESPQGK VLQVIVWGDY GRMDHKCFMG VAQILLEELD LSSMVIGWYK 1450 1460 1470 LFPPSSLVDP TLTPLTRRAS QSSLESSTGP PCIRS
	Isoform 6 (Rab3 interacting protein variant 4) [UniParc]. Checksum: 815C71ECFEF6D8C5	FASTA	1,371	153,500
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 1040 1050 1060 1070 1080 LMLPRAKRGR SAECLHTTSE LQPFLDRARS ASTNCLRPDT SLHSPERERG RWSPSLDRRR 1090 1100 1110 1120 1130 1140 PPSPRIQIQH ASPENDRMHR QRSPTQSPPA DTSFSSRRGR QLPQVPVRSG SIEQESGHKK 1150 1160 1170 1180 1190 1200 LKSTIQRSTE TGMAAEMRKM VRQPSRESTD GSINSYSSEG NLIFPGVRLG ADSQFSDFLD 1210 1220 1230 1240 1250 1260 GLGPAQLVGR QTLATPAMGD IQIGMEDKKG QLEVEVIRAR SLTQKPGSKS TPAPYVKVYL 1270 1280 1290 1300 1310 1320 LENGACIAKK KTRIARKTLD PLYQQSLVFD ESPQGKVLQV IVWGDYGRMD HKCFMGVAQI 1330 1340 1350 1360 1370 LLEELDLSSM VIGWYKLFPP SSLVDPTLTP LTRRASQSSL ESSTGPPCIR S
	Isoform 7 (Rab3 interacting protein variant 5) [UniParc]. Checksum: 87E88E425651F382	FASTA	1,342	150,109
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPGYRSSAR ESKSTTLTVP EQQRTTHHRS RSVSPHRGND 970 980 990 1000 1010 1020 QGKPRSRLPN VPLQRSLDEI HPTRRSRSPT RHHDASRSPV DHRTRDVDSQ YLSEQDSELL 1030 1040 1050 1060 1070 1080 MLPRAKRGRS AECLHTTSEL QPFLDRARSA STNCLRPDTS LHSPERERMH RQRSPTQSPP 1090 1100 1110 1120 1130 1140 ADTSFSSRRG RQLPQVPVRS GSIEQESGHK KLKSTIQRST ETGMAAEMRK MVRQPSREST 1150 1160 1170 1180 1190 1200 DGSINSYSSE GNLIFPGVRL GADSQFSDFL DGLGPAQLVG RQTLATPAMG DIQIGMEDKK 1210 1220 1230 1240 1250 1260 GQLEVEVIRA RSLTQKPGSK STPAPYVKVY LLENGACIAK KKTRIARKTL DPLYQQSLVF 1270 1280 1290 1300 1310 1320 DESPQGKVLQ VIVWGDYGRM DHKCFMGVAQ ILLEELDLSS MVIGWYKLFP PSSLVDPTLT 1330 1340 PLTRRASQSS LESSTGPPCI RS
	Isoform 8 (Rab3 interacting protein variant 6) [UniParc]. Checksum: 8D52C8AD83A640AD	FASTA	1,291	144,361
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPGYRSSAR ESKSTTLTVP EQQRTTHHRS RSVSPHRGND 970 980 990 1000 1010 1020 QGKPRSRLPN VPLQRSLDEI HPTRRSRSPT RHHDASRSPV DHRTRDVDSQ YLSEQDRMHR 1030 1040 1050 1060 1070 1080 QRSPTQSPPA DTSFSSRRGR QLPQVPVRSG SIEQESGHKK LKSTIQRSTE TGMAAEMRKM 1090 1100 1110 1120 1130 1140 VRQPSRESTD GSINSYSSEG NLIFPGVRLG ADSQFSDFLD GLGPAQLVGR QTLATPAMGD 1150 1160 1170 1180 1190 1200 IQIGMEDKKG QLEVEVIRAR SLTQKPGSKS TPAPYVKVYL LENGACIAKK KTRIARKTLD 1210 1220 1230 1240 1250 1260 PLYQQSLVFD ESPQGKVLQV IVWGDYGRMD HKCFMGVAQI LLEELDLSSM VIGWYKLFPP 1270 1280 1290 SSLVDPTLTP LTRRASQSSL ESSTGPPCIR S
	Isoform 9 [UniParc]. Checksum: C20C62181371B83B	FASTA	826	92,731
	10 20 30 40 50 60 MFAGFLQFLL LHTLHSGTGD LDYYWLDPAT WHSRETSPIS SHPVTWQPSK EGDRLIGRVI 70 80 90 100 110 120 LNKRTTMPKD SGALLGLKVV GGKMTDLGRL GAFITKVKKG SLADVVGHLR AGDEVLEWNG 130 140 150 160 170 180 KPLPGATNEE VYNIILESKS EPQVEIIVSR PIGDIPRIPE SSHPPLESSS SSFESQKMER 190 200 210 220 230 240 PSISVISPTS PGALKDAPQV LPGQLSVKLW YDKVGHQLIV NVLQATDLPA RVDGRPRNPY 250 260 270 280 290 300 VKMYFLPDRS DKSKRRTKTV KKILEPKWNQ TFVYSHVHRR DFRERMLEIT VWDQPRVQEE 310 320 330 340 350 360 ESEFLGEILI ELETALLDDE PHWYKLQTHD ESSLPLPQPS PFMPRRHIHG ESSSKKLQRS 370 380 390 400 410 420 QRISDSDISD YEVDDGIGVV PPVGYRSSAR ESKSTTLTVP EQQRTTHHRS RSVSPHRGND 430 440 450 460 470 480 QGKPRSRLPN VPLQRSLDEI HPTRRSRSPT RHHDASRSPV DHRTRDVDSQ YLSEQDSELL 490 500 510 520 530 540 MLPRAKRGRS AECLHTTSEL QPFLDRARSA STNCLRPDTS LHSPERERHS RKSERSSIQK 550 560 570 580 590 600 QTRKGTASDA ERMHRQRSPT QSPPADTSFS SRRGRQLPQV PVRSGSIEQE SGHKKLKSTI 610 620 630 640 650 660 QRSTETGMAA EMRKMVRQPS RESTDGSINS YSSEGNLIFP GVRLGADSQF SDFLDGLGPA 670 680 690 700 710 720 QLVGRQTLAT PAMGDIQIGM EDKKGQLEVE VIRARSLTQK PGSKSTPAPY VKVYLLENGA 730 740 750 760 770 780 CIAKKKTRIA RKTLDPLYQQ SLVFDESPQG KVLQVIVWGD YGRMDHKCFM GVAQILLEEL 790 800 810 820 DLSSMVIGWY KLFPPSSLVD PTLTPLTRRA SQSSLESSTG PPCIRS
	Isoform 10 [UniParc]. Checksum: 1BC5B3BB0B105D6B	FASTA	760	85,152
	10 20 30 40 50 60 MPKDSGALLG LKVVGGKMTD LGRLGAFITK VKKGSLADVV GHLRAGDEVL EWNGKPLPGA 70 80 90 100 110 120 TNEEVYNIIL ESKSEPQVEI IVSRPIGDIP RIPESSHPPL ESSSSSFESQ KMERPSISVI 130 140 150 160 170 180 SPTSPGALKD APQVLPGQLS VKLWYDKVGH QLIVNVLQAT DLPARVDGRP RNPYVKMYFL 190 200 210 220 230 240 PDRSDKSKRR TKTVKKILEP KWNQTFVYSH VHRRDFRERM LEITVWDQPR VQEEESEFLG 250 260 270 280 290 300 EILIELETAL LDDEPHWYKL QTHDESSLPL PQPSPFMPRR HIHGESSSKK LQRSQRISDS 310 320 330 340 350 360 DISDYEVDDG IGVVPPVGYR SSARESKSTT LTVPEQQRTT HHRSRSVSPH RGNDQGKPRS 370 380 390 400 410 420 RLPNVPLQRS LDEIHPTRRS RSPTRHHDAS RSPVDHRTRD VDSQYLSEQD SELLMLPRAK 430 440 450 460 470 480 RGRSAECLHT TSELQPFLDR ARSASTNCLR PDTSLHSPER ERHSRKSERS SIQKQTRKGT 490 500 510 520 530 540 ASDAERMHRQ RSPTQSPPAD TSFSSRRGRQ LPQVPVRSGS IEQESGHKKL KSTIQRSTET 550 560 570 580 590 600 GMAAEMRKMV RQPSRESTDG SINSYSSEGN LIFPGVRLGA DSQFSDFLDG LGPAQLVGRQ 610 620 630 640 650 660 TLATPAMGDI QIGMEDKKGQ LEVEVIRARS LTQKPGSKST PAPYVKVYLL ENGACIAKKK 670 680 690 700 710 720 TRIARKTLDP LYQQSLVFDE SPQGKVLQVI VWGDYGRMDH KCFMGVAQIL LEELDLSSMV 730 740 750 760 IGWYKLFPPS SLVDPTLTPL TRRASQSSLE SSTGPPCIRS
	Isoform 11 [UniParc]. Checksum: 9906E3592B6D9848	FASTA	219	24,013
	10 20 30 40 50 60 MAAEMRKMVR QPSRESTDGS INSYSSEGNL IFPGVRLGAD SQFSDFLDGL GPAQLVGRQT 70 80 90 100 110 120 LATPAMGDIQ IGMEDKKGQL EVEVIRARSL TQKPGSKSTP APYVKVYLLE NGACIAKKKT 130 140 150 160 170 180 RIARKTLDPL YQQSLVFDES PQGKVLQVIV WGDYGRMDHK CFMGVAQILL EELDLSSMVI 190 200 210 GWYKLFPPSS LVDPTLTPLT RRASQSSLES STGPPCIRS

References

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[1]	"Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7)." Johnson S., Halford S., Morris A.G., Patel R.J., Wilkie S.E., Hardcastle A.J., Moore A.T., Zhang K., Hunt D.M. Genomics 81:304-314(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT CORD7 HIS-820.
[2]	"Identification of the alternative form of human RIM." Aoyama M., Asai K., Shishikura T., Ohira M., Inuzuka H., Morohashi A., Kato T., Nakagawara A. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3). Tissue: Neuroblastoma.
[3]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 9; 10 AND 11). Tissue: Small intestine and Thalamus.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[7]	"Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin." Coppola T., Magnin-Luethi S., Perret-Menoud V., Gattesco S., Schiavo G., Regazzi R. J. Biol. Chem. 276:32756-32762(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 776-1692 (ISOFORMS 3; 4; 5; 6; 7 AND 8), MUTAGENESIS OF 796-LYS-LYS-797 AND 1591-ARG-ARG-1592, INTERACTION WITH SNAP25; SYT1 AND CACNA1B. Tissue: Brain.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1677; SER-1680; SER-1683 AND SER-1692, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Solution structure of the PDZ domain of human KIAA0340 protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 585-694.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY190519 mRNA. Translation: AAO38848.1.
AB045726 mRNA. Translation: BAB87121.1.
AB051866 mRNA. Translation: BAB87242.1.
AB002338 mRNA. Translation: BAA20798.1. Different initiation.
AK296303 mRNA. Translation: BAH12309.1.
AK300853 mRNA. Translation: BAH13358.1.
AK309185 mRNA. No translation available.
AL160405 Genomic DNA. No translation available.
AL590011 , AL034373, AL390056, AL445256 Genomic DNA. Translation: CAI16961.1.
AL034373 , AL390056, AL445256, AL590011 Genomic DNA. Translation: CAI20558.1.
AL390056 , AL034373, AL445256, AL590011 Genomic DNA. Translation: CAI21554.1.
AL445256 , AL034373, AL390056, AL590011 Genomic DNA. Translation: CAI39598.1.
AL445256, AL035633 Genomic DNA. Translation: CAI39600.1. Sequence problems.
AL445256, AL035633 Genomic DNA. Translation: CAI39604.1.
AL035633, AL445256 Genomic DNA. Translation: CAI42135.1. Sequence problems.
AL035633, AL445256 Genomic DNA. Translation: CAI42139.1.
BC151853 mRNA. Translation: AAI51854.1.
BC152435 mRNA. Translation: AAI52436.1.
AF263305 mRNA. Translation: AAG23162.1.
AF263306 mRNA. Translation: AAG23163.1.
AF263307 mRNA. Translation: AAG23164.1.
AF263308 mRNA. Translation: AAG23165.1.
AF263309 mRNA. Translation: AAG23166.1.
AF263310 mRNA. Translation: AAG23167.1.

IPI

IPI00339392.
IPI00339394.
IPI00339396.
IPI00387015.
IPI00387018.
IPI00387019.
IPI00472331.
IPI00848003.
IPI00954906.
IPI00978698.
IPI00985079.

RefSeq

NP_001161882.1. NM_001168410.1.
NP_001161883.1. NM_001168411.1.
NP_055804.2. NM_014989.5.

UniGene

Hs.485729.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CSS	NMR	-	A	585-692	[»]

ProteinModelPortal

Q86UR5.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q86UR5. 5 interactions.

MINT

MINT-2808819.

PTM databases

PhosphoSite

Q86UR5.

Polymorphism databases

DMDM

34395763.

Proteomic databases

PaxDb

Q86UR5.

PRIDE

Q86UR5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000264839; ENSP00000264839; ENSG00000079841.
ENST00000370420; ENSP00000359448; ENSG00000079841.
ENST00000414192; ENSP00000402273; ENSG00000079841.
ENST00000425662; ENSP00000411235; ENSG00000079841.
ENST00000491071; ENSP00000430101; ENSG00000079841.
ENST00000517827; ENSP00000428367; ENSG00000079841.
ENST00000517960; ENSP00000429959; ENSG00000079841.
ENST00000518273; ENSP00000430408; ENSG00000079841.
ENST00000520567; ENSP00000430502; ENSG00000079841.
ENST00000521978; ENSP00000428417; ENSG00000079841.
ENST00000522291; ENSP00000430932; ENSG00000079841.

GeneID

22999.

KEGG

hsa:22999.

UCSC

uc003pga.3. human.
uc003pgb.4. human.
uc003pge.3. human.
uc010kar.3. human.
uc010kas.1. human.
uc011dyg.2. human.

Organism-specific databases

CTD

22999.

GeneCards

GC06P072653.

HGNC

HGNC:17282. RIMS1.

HPA

HPA039297.

MIM

603649. phenotype.
606629. gene.

neXtProt

NX_Q86UR5.

Orphanet

1872. Cone rod dystrophy.

PharmGKB

PA38220.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG286957.

HOGENOM

HOG000082403.

HOVERGEN

HBG058147.

InParanoid

Q86UR5.

KO

K15291.

OMA

ERKKTPG.

Enzyme and pathway databases

Pathway_Interaction_DB

botulinumtoxinpathway. Effects of Botulinum toxin.

Reactome

REACT_13685. Neuronal System.

Gene expression databases

ArrayExpress

Q86UR5.

Bgee

Q86UR5.

Genevestigator

Q86UR5.

GermOnline

ENSG00000079841. Homo sapiens.

Family and domain databases

Gene3D

3.30.40.10. 1 hit.

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR001478. PDZ.
IPR010911. Rab-bd_domain.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF00168. C2. 2 hits.
PF00595. PDZ. 1 hit.
[Graphical view]

SMART

SM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 2 hits.
SSF57903. FYVE_PHD_ZnF. 1 hit.
SSF50156. PDZ. 1 hit.

PROSITE

PS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RIMS1. human.

EvolutionaryTrace

Q86UR5.

GenomeRNAi

22999.

NextBio

43896.

SOURCE

Search...

Entry information

Entry name

RIMS1_HUMAN

Accession

Primary (citable) accession number: Q86UR5
Secondary accession number(s): A7MBN6 , B7Z3S3, B7Z6S2, E7EX08, E9PCB7, E9PCZ1, E9PHR1, O15048, Q5JY21, Q5JY25, Q5SZK1, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.