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Q86UR5

- RIMS1_HUMAN

UniProt

Q86UR5 - RIMS1_HUMAN

Protein

Regulating synaptic membrane exocytosis protein 1

Gene

RIMS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri110 – 17061FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. small GTPase regulator activity Source: UniProtKB

    GO - Biological processi

    1. calcium ion-dependent exocytosis Source: UniProtKB
    2. calcium ion-dependent exocytosis of neurotransmitter Source: Ensembl
    3. glutamate secretion Source: Reactome
    4. intracellular protein transport Source: InterPro
    5. membrane fusion Source: UniProtKB
    6. neurotransmitter secretion Source: Reactome
    7. protein complex assembly Source: UniProtKB
    8. regulated secretory pathway Source: UniProtKB
    9. regulation of catalytic activity Source: GOC
    10. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    11. regulation of membrane potential Source: Ensembl
    12. response to stimulus Source: UniProtKB-KW
    13. secretion Source: UniProtKB
    14. synaptic transmission Source: Reactome
    15. synaptic vesicle exocytosis Source: UniProtKB
    16. visual perception Source: UniProtKB-KW

    Keywords - Biological processi

    Exocytosis, Neurotransmitter transport, Sensory transduction, Transport, Vision

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_15293. Dopamine Neurotransmitter Release Cycle.
    REACT_15309. Acetylcholine Neurotransmitter Release Cycle.
    REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
    REACT_15425. Serotonin Neurotransmitter Release Cycle.
    REACT_23947. GABA synthesis, release, reuptake and degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulating synaptic membrane exocytosis protein 1
    Alternative name(s):
    Rab-3-interacting molecule 1
    Short name:
    RIM 1
    Rab-3-interacting protein 2
    Gene namesi
    Name:RIMS1
    Synonyms:KIAA0340, RAB3IP2, RIM1
    ORF Names:Nbla00761
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17282. RIMS1.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity. Cell junctionsynapse By similarity. Cell junctionsynapsepresynaptic cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    3. presynaptic membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Synapse

    Pathology & Biotechi

    Involvement in diseasei

    Cone-rod dystrophy 7 (CORD7) [MIM:603649]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.1 Publication
    Note: The disease may be caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti820 – 8201R → H in CORD7. 1 Publication
    VAR_016804

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi796 – 7972RR → AA: Abolishes interaction with SYT1 and CACNA1B. 1 Publication
    Mutagenesisi1591 – 15922KK → AA: Abolishes interaction with SYT1 and CACNA1B. 1 Publication

    Keywords - Diseasei

    Cone-rod dystrophy, Disease mutation

    Organism-specific databases

    MIMi603649. phenotype.
    Orphaneti1872. Cone rod dystrophy.
    PharmGKBiPA38220.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16921692Regulating synaptic membrane exocytosis protein 1PRO_0000190198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1677 – 16771Phosphoserine1 Publication
    Modified residuei1680 – 16801Phosphoserine1 Publication
    Modified residuei1683 – 16831Phosphoserine1 Publication
    Modified residuei1692 – 16921Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated by BRSK1.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86UR5.
    PaxDbiQ86UR5.
    PRIDEiQ86UR5.

    PTM databases

    PhosphoSiteiQ86UR5.

    Expressioni

    Tissue specificityi

    Detected in brain and retina.

    Gene expression databases

    ArrayExpressiQ86UR5.
    BgeeiQ86UR5.
    GenevestigatoriQ86UR5.

    Organism-specific databases

    HPAiHPA039297.

    Interactioni

    Subunit structurei

    Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Interacts with RAB3C, RAB10, RAB26 AND RAB37. Binds UNC13A. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts with ERC1 By similarity. Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABL1P005192EBI-1043236,EBI-375543

    Protein-protein interaction databases

    BioGridi116646. 13 interactions.
    IntActiQ86UR5. 5 interactions.
    MINTiMINT-2808819.

    Structurei

    Secondary structure

    1
    1692
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi585 – 5895
    Beta strandi591 – 60212
    Beta strandi609 – 6113
    Beta strandi616 – 62510
    Beta strandi629 – 63810
    Helixi643 – 6464
    Beta strandi655 – 6617
    Helixi669 – 67810
    Helixi679 – 6813
    Beta strandi685 – 6917

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CSSNMR-A585-692[»]
    ProteinModelPortaliQ86UR5.
    SMRiQ86UR5. Positions 113-170, 583-691, 745-871, 1524-1671.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ86UR5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 182161RabBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini605 – 69187PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini744 – 850107C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1538 – 1640103C2 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1336 – 140267Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 C2 domains.PROSITE-ProRule annotation
    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri110 – 17061FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG286957.
    HOGENOMiHOG000082403.
    HOVERGENiHBG058147.
    InParanoidiQ86UR5.
    KOiK15291.
    OMAiERKKTPG.
    OrthoDBiEOG7BGHJV.
    PhylomeDBiQ86UR5.
    TreeFamiTF321703.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    2.60.40.150. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR001478. PDZ.
    IPR017455. Znf_FYVE-rel.
    IPR010911. Znf_FYVE-typ.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00168. C2. 2 hits.
    PF02318. FYVE_2. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 2 hits.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    SSF50156. SSF50156. 1 hit.
    SSF57903. SSF57903. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50916. RABBD. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequences (13)i

    Sequence statusi: Complete.

    This entry describes 13 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q86UR5-1) [UniParc]FASTAAdd to Basket

    Also known as: RIM1 alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE     50
    EAMLKCVVRD MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE 100
    EARRYQGEHK DDAPTCGICH KTKFADGCGH LCSYCRTKFC ARCGGRVSLR 150
    SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF GSGPQQTSQD GTLSDTATGA 200
    GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD RSKGAEPSQQ 250
    ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 300
    VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED 350
    YQTRYRSDPN LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA 400
    GAALPEGKAG KRAPAAARAS PPDSPRAYSA ERTAETRAPG AKQLTNHSPP 450
    APRHGPVPAE APELKAQEPL RKQSRLDPSS AVLMRKAKRE KVETMLRNDS 500
    LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST PEYTSCEDVE 550
    LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 600
    ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL 650
    RAGDEVLEWN GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP 700
    ESSHPPLESS SSSFESQKME RPSISVISPT SPGALKDAPQ VLPGQLSVKL 750
    WYDKVGHQLI VNVLQATDLP ARVDGRPRNP YVKMYFLPDR SDKSKRRTKT 800
    VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE EESEFLGEIL 850
    IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 900
    SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR 950
    SRSVSPHRGN DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP 1000
    VDHRTRDVDS QYLSEQDSEL LMLPRAKRGR SAECLHTTRH LVRHYKTLPP 1050
    KMPLLQSSSH WNIYSSILPA HTKTKSVTRQ DISLHHECFN STVLRFTDEI 1100
    LVSELQPFLD RARSASTNCL RPDTSLHSPE RERGRWSPSL DRRRPPSPRI 1150
    QIQHASPEND RHSRKSERSS IQKQTRKGTA SDAERVLPTC LSRRGHAAPR 1200
    ATDQPVIRGK HPARSRSSEH SSIRTLCSMH HLVPGGSAPP SPLLTRMHRQ 1250
    RSPTQSPPAD TSFSSRRGRQ LPQVPVRSGS IEQASLVVEE RTRQMKMKVH 1300
    RFKQTTGSGS SQELDREQYS KYNIHKDQYR SCDNVSAKSS DSDVSDVSAI 1350
    SRTSSASRLS STSFMSEQSE RPRGRISSFT PKMQGRRMGT SGRSIMKSTS 1400
    VSGEMYTLEH NDGSQSDTAV GTVGAGGKKR RSSLSAKVVA IVSRRSRSTS 1450
    QLSQTESGHK KLKSTIQRST ETGMAAEMRK MVRQPSREST DGSINSYSSE 1500
    GNLIFPGVRL GADSQFSDFL DGLGPAQLVG RQTLATPAMG DIQIGMEDKK 1550
    GQLEVEVIRA RSLTQKPGSK STPAPYVKVY LLENGACIAK KKTRIARKTL 1600
    DPLYQQSLVF DESPQGKVLQ VIVWGDYGRM DHKCFMGVAQ ILLEELDLSS 1650
    MVIGWYKLFP PSSLVDPTLT PLTRRASQSS LESSTGPPCI RS 1692
    Length:1,692
    Mass (Da):189,073
    Last modified:June 1, 2003 - v1
    Checksum:i0A96642DC832C15E
    GO
    Isoform 2 (identifier: Q86UR5-2) [UniParc]FASTAAdd to Basket

    Also known as: RIM short form

    The sequence of this isoform differs from the canonical sequence as follows:
         1040-1692: Missing.

    Note: May be due to intron retention.

    Show »
    Length:1,039
    Mass (Da):116,704
    Checksum:iEF56FBC20E5A629E
    GO
    Isoform 3 (identifier: Q86UR5-3) [UniParc]FASTAAdd to Basket

    Also known as: RIM long form, Rab3 interacting protein variant 2

    The sequence of this isoform differs from the canonical sequence as follows:
         1039-1102: Missing.
         1133-1245: Missing.
         1540-1573: Missing.

    Show »
    Length:1,481
    Mass (Da):165,360
    Checksum:iF34E4B8FAF1D35FD
    GO
    Isoform 4 (identifier: Q86UR5-4) [UniParc]FASTAAdd to Basket

    Also known as: Rab3 interacting protein variant 1

    The sequence of this isoform differs from the canonical sequence as follows:
         1065-1102: Missing.
         1133-1245: Missing.

    Show »
    Length:1,541
    Mass (Da):172,224
    Checksum:i98A7006DC8206CB3
    GO
    Isoform 5 (identifier: Q86UR5-5) [UniParc]FASTAAdd to Basket

    Also known as: Rab3 interacting protein variant 3

    The sequence of this isoform differs from the canonical sequence as follows:
         924-924: Missing.
         1038-1244: Missing.
         1377-1385: Missing.

    Show »
    Length:1,475
    Mass (Da):164,580
    Checksum:i8192B1AF38A1661B
    GO
    Isoform 6 (identifier: Q86UR5-6) [UniParc]FASTAAdd to Basket

    Also known as: Rab3 interacting protein variant 4

    The sequence of this isoform differs from the canonical sequence as follows:
         1039-1102: Missing.
         1161-1245: Missing.
         1284-1455: Missing.

    Show »
    Length:1,371
    Mass (Da):153,500
    Checksum:i815C71ECFEF6D8C5
    GO
    Isoform 7 (identifier: Q86UR5-7) [UniParc]FASTAAdd to Basket

    Also known as: Rab3 interacting protein variant 5

    The sequence of this isoform differs from the canonical sequence as follows:
         924-924: Missing.
         1039-1102: Missing.
         1133-1245: Missing.
         1284-1455: Missing.

    Show »
    Length:1,342
    Mass (Da):150,109
    Checksum:i87E88E425651F382
    GO
    Isoform 8 (identifier: Q86UR5-8) [UniParc]FASTAAdd to Basket

    Also known as: Rab3 interacting protein variant 6

    The sequence of this isoform differs from the canonical sequence as follows:
         924-924: Missing.
         1018-1245: Missing.
         1284-1455: Missing.

    Show »
    Length:1,291
    Mass (Da):144,361
    Checksum:i8D52C8AD83A640AD
    GO
    Isoform 9 (identifier: Q86UR5-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: MSSAVGPRGPRPPTVPPP → MFAGFLQFLLLHTLHSGT
         19-559: Missing.
         1039-1102: Missing.
         1133-1160: Missing.
         1185-1245: Missing.
         1284-1455: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:826
    Mass (Da):92,731
    Checksum:iC20C62181371B83B
    GO
    Isoform 10 (identifier: Q86UR5-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-607: Missing.
         1039-1102: Missing.
         1133-1160: Missing.
         1185-1245: Missing.
         1284-1455: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:760
    Mass (Da):85,152
    Checksum:i1BC5B3BB0B105D6B
    GO
    Isoform 11 (identifier: Q86UR5-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1473: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:219
    Mass (Da):24,013
    Checksum:i9906E3592B6D9848
    GO
    Isoform 12 (identifier: Q86UR5-12) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-559: MSSAVGPRGP...ELESESVSEK → MCAPGIHVSSEGWEEVRSVDSEEGTIEARRAVA
         924-924: Missing.
         1039-1102: Missing.
         1133-1160: Missing.
         1185-1245: Missing.

    Show »
    Length:1,012
    Mass (Da):112,988
    Checksum:iA6F0E2D8AFE8B426
    GO
    Isoform 13 (identifier: Q86UR5-13) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-559: MSSAVGPRGP...ELESESVSEK → MCAPGIHVSSEGWEEVRSVDSEEGTIEARRAVA
         1039-1102: Missing.
         1133-1245: Missing.
         1284-1455: Missing.

    Show »
    Length:817
    Mass (Da):91,530
    Checksum:i97107E7A7F961EC8
    GO

    Sequence cautioni

    The sequence BAA20798.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI39600.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI42135.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti157 – 1571V → Y in CAI16961. (PubMed:14574404)Curated
    Sequence conflicti484 – 49411Missing in BAB87121. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti484 – 49411Missing in BAB87242. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti484 – 49411Missing in BAA20798. (PubMed:9205841)CuratedAdd
    BLAST
    Sequence conflicti484 – 49411Missing in AAI51854. (PubMed:15489334)CuratedAdd
    BLAST
    Sequence conflicti484 – 49411Missing in AAI52436. (PubMed:15489334)CuratedAdd
    BLAST
    Sequence conflicti1272 – 12721P → S in BAH11945. (PubMed:14702039)Curated
    Sequence conflicti1606 – 16061Q → R in BAH11906. (PubMed:14702039)Curated
    Sequence conflicti1609 – 16091V → A in BAH13358. (PubMed:14702039)Curated
    Sequence conflicti1662 – 16621S → P in AK309185. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti820 – 8201R → H in CORD7. 1 Publication
    VAR_016804

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 14731473Missing in isoform 11. 1 PublicationVSP_045485Add
    BLAST
    Alternative sequencei1 – 607607Missing in isoform 10. 1 PublicationVSP_045486Add
    BLAST
    Alternative sequencei1 – 559559MSSAV…SVSEK → MCAPGIHVSSEGWEEVRSVD SEEGTIEARRAVA in isoform 12 and isoform 13. 1 PublicationVSP_046796Add
    BLAST
    Alternative sequencei1 – 1818MSSAV…TVPPP → MFAGFLQFLLLHTLHSGT in isoform 9. 1 PublicationVSP_043177Add
    BLAST
    Alternative sequencei19 – 559541Missing in isoform 9. 1 PublicationVSP_043178Add
    BLAST
    Alternative sequencei924 – 9241Missing in isoform 5, isoform 7, isoform 8 and isoform 12. 2 PublicationsVSP_008161
    Alternative sequencei1018 – 1245228Missing in isoform 8. 1 PublicationVSP_008162Add
    BLAST
    Alternative sequencei1038 – 1244207Missing in isoform 5. 1 PublicationVSP_008163Add
    BLAST
    Alternative sequencei1039 – 110264Missing in isoform 3, isoform 6, isoform 7, isoform 9, isoform 10, isoform 12 and isoform 13. 3 PublicationsVSP_008164Add
    BLAST
    Alternative sequencei1040 – 1692653Missing in isoform 2. 3 PublicationsVSP_008165Add
    BLAST
    Alternative sequencei1065 – 110238Missing in isoform 4. 1 PublicationVSP_008166Add
    BLAST
    Alternative sequencei1133 – 1245113Missing in isoform 3, isoform 4, isoform 7 and isoform 13. 3 PublicationsVSP_008167Add
    BLAST
    Alternative sequencei1133 – 116028Missing in isoform 9, isoform 10 and isoform 12. 1 PublicationVSP_043179Add
    BLAST
    Alternative sequencei1161 – 124585Missing in isoform 6. 1 PublicationVSP_008168Add
    BLAST
    Alternative sequencei1185 – 124561Missing in isoform 9, isoform 10 and isoform 12. 1 PublicationVSP_043180Add
    BLAST
    Alternative sequencei1284 – 1455172Missing in isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 13. 2 PublicationsVSP_008169Add
    BLAST
    Alternative sequencei1377 – 13859Missing in isoform 5. 1 PublicationVSP_008170
    Alternative sequencei1540 – 157334Missing in isoform 3. 2 PublicationsVSP_008171Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY190519 mRNA. Translation: AAO38848.1.
    AB045726 mRNA. Translation: BAB87121.1.
    AB051866 mRNA. Translation: BAB87242.1.
    AB002338 mRNA. Translation: BAA20798.1. Different initiation.
    AK296303 mRNA. Translation: BAH12309.1.
    AK294868 mRNA. Translation: BAH11906.1.
    AK295001 mRNA. Translation: BAH11945.1.
    AK300853 mRNA. Translation: BAH13358.1.
    AK309185 mRNA. No translation available.
    AL160405 Genomic DNA. No translation available.
    AL590011
    , AL034373, AL390056, AL445256 Genomic DNA. Translation: CAI16961.1.
    AL034373
    , AL390056, AL445256, AL590011 Genomic DNA. Translation: CAI20558.1.
    AL390056
    , AL034373, AL445256, AL590011 Genomic DNA. Translation: CAI21554.1.
    AL445256
    , AL034373, AL390056, AL590011 Genomic DNA. Translation: CAI39598.1.
    AL445256, AL035633 Genomic DNA. Translation: CAI39600.1. Sequence problems.
    AL445256, AL035633 Genomic DNA. Translation: CAI39604.1.
    AL035633, AL445256 Genomic DNA. Translation: CAI42135.1. Sequence problems.
    AL035633, AL445256 Genomic DNA. Translation: CAI42139.1.
    BC151853 mRNA. Translation: AAI51854.1.
    BC152435 mRNA. Translation: AAI52436.1.
    AF263305 mRNA. Translation: AAG23162.1.
    AF263306 mRNA. Translation: AAG23163.1.
    AF263307 mRNA. Translation: AAG23164.1.
    AF263308 mRNA. Translation: AAG23165.1.
    AF263309 mRNA. Translation: AAG23166.1.
    AF263310 mRNA. Translation: AAG23167.1.
    CCDSiCCDS47449.1. [Q86UR5-1]
    CCDS55029.1. [Q86UR5-13]
    CCDS55030.1. [Q86UR5-12]
    CCDS55031.1. [Q86UR5-9]
    CCDS55032.1. [Q86UR5-10]
    CCDS55033.1. [Q86UR5-11]
    RefSeqiNP_001161879.1. NM_001168407.1. [Q86UR5-12]
    NP_001161880.1. NM_001168408.1. [Q86UR5-13]
    NP_001161881.1. NM_001168409.1. [Q86UR5-10]
    NP_001161882.1. NM_001168410.1. [Q86UR5-9]
    NP_001161883.1. NM_001168411.1. [Q86UR5-11]
    NP_055804.2. NM_014989.5. [Q86UR5-1]
    XP_006715451.1. XM_006715388.1. [Q86UR5-5]
    UniGeneiHs.485729.

    Genome annotation databases

    EnsembliENST00000264839; ENSP00000264839; ENSG00000079841. [Q86UR5-4]
    ENST00000370420; ENSP00000359448; ENSG00000079841.
    ENST00000401910; ENSP00000385649; ENSG00000079841. [Q86UR5-12]
    ENST00000414192; ENSP00000402273; ENSG00000079841. [Q86UR5-11]
    ENST00000425662; ENSP00000411235; ENSG00000079841. [Q86UR5-10]
    ENST00000491071; ENSP00000430101; ENSG00000079841. [Q86UR5-3]
    ENST00000517827; ENSP00000428367; ENSG00000079841. [Q86UR5-9]
    ENST00000517960; ENSP00000429959; ENSG00000079841. [Q86UR5-5]
    ENST00000518273; ENSP00000430408; ENSG00000079841. [Q86UR5-6]
    ENST00000520567; ENSP00000430502; ENSG00000079841. [Q86UR5-7]
    ENST00000521978; ENSP00000428417; ENSG00000079841. [Q86UR5-1]
    ENST00000522291; ENSP00000430932; ENSG00000079841. [Q86UR5-8]
    ENST00000523963; ENSP00000428328; ENSG00000079841. [Q86UR5-13]
    GeneIDi22999.
    KEGGihsa:22999.
    UCSCiuc003pga.4. human. [Q86UR5-1]
    uc003pgb.4. human. [Q86UR5-2]
    uc003pgc.3. human. [Q86UR5-3]
    uc010kas.1. human. [Q86UR5-9]

    Polymorphism databases

    DMDMi34395763.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY190519 mRNA. Translation: AAO38848.1 .
    AB045726 mRNA. Translation: BAB87121.1 .
    AB051866 mRNA. Translation: BAB87242.1 .
    AB002338 mRNA. Translation: BAA20798.1 . Different initiation.
    AK296303 mRNA. Translation: BAH12309.1 .
    AK294868 mRNA. Translation: BAH11906.1 .
    AK295001 mRNA. Translation: BAH11945.1 .
    AK300853 mRNA. Translation: BAH13358.1 .
    AK309185 mRNA. No translation available.
    AL160405 Genomic DNA. No translation available.
    AL590011
    , AL034373 , AL390056 , AL445256 Genomic DNA. Translation: CAI16961.1 .
    AL034373
    , AL390056 , AL445256 , AL590011 Genomic DNA. Translation: CAI20558.1 .
    AL390056
    , AL034373 , AL445256 , AL590011 Genomic DNA. Translation: CAI21554.1 .
    AL445256
    , AL034373 , AL390056 , AL590011 Genomic DNA. Translation: CAI39598.1 .
    AL445256 , AL035633 Genomic DNA. Translation: CAI39600.1 . Sequence problems.
    AL445256 , AL035633 Genomic DNA. Translation: CAI39604.1 .
    AL035633 , AL445256 Genomic DNA. Translation: CAI42135.1 . Sequence problems.
    AL035633 , AL445256 Genomic DNA. Translation: CAI42139.1 .
    BC151853 mRNA. Translation: AAI51854.1 .
    BC152435 mRNA. Translation: AAI52436.1 .
    AF263305 mRNA. Translation: AAG23162.1 .
    AF263306 mRNA. Translation: AAG23163.1 .
    AF263307 mRNA. Translation: AAG23164.1 .
    AF263308 mRNA. Translation: AAG23165.1 .
    AF263309 mRNA. Translation: AAG23166.1 .
    AF263310 mRNA. Translation: AAG23167.1 .
    CCDSi CCDS47449.1. [Q86UR5-1 ]
    CCDS55029.1. [Q86UR5-13 ]
    CCDS55030.1. [Q86UR5-12 ]
    CCDS55031.1. [Q86UR5-9 ]
    CCDS55032.1. [Q86UR5-10 ]
    CCDS55033.1. [Q86UR5-11 ]
    RefSeqi NP_001161879.1. NM_001168407.1. [Q86UR5-12 ]
    NP_001161880.1. NM_001168408.1. [Q86UR5-13 ]
    NP_001161881.1. NM_001168409.1. [Q86UR5-10 ]
    NP_001161882.1. NM_001168410.1. [Q86UR5-9 ]
    NP_001161883.1. NM_001168411.1. [Q86UR5-11 ]
    NP_055804.2. NM_014989.5. [Q86UR5-1 ]
    XP_006715451.1. XM_006715388.1. [Q86UR5-5 ]
    UniGenei Hs.485729.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CSS NMR - A 585-692 [» ]
    ProteinModelPortali Q86UR5.
    SMRi Q86UR5. Positions 113-170, 583-691, 745-871, 1524-1671.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116646. 13 interactions.
    IntActi Q86UR5. 5 interactions.
    MINTi MINT-2808819.

    PTM databases

    PhosphoSitei Q86UR5.

    Polymorphism databases

    DMDMi 34395763.

    Proteomic databases

    MaxQBi Q86UR5.
    PaxDbi Q86UR5.
    PRIDEi Q86UR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264839 ; ENSP00000264839 ; ENSG00000079841 . [Q86UR5-4 ]
    ENST00000370420 ; ENSP00000359448 ; ENSG00000079841 .
    ENST00000401910 ; ENSP00000385649 ; ENSG00000079841 . [Q86UR5-12 ]
    ENST00000414192 ; ENSP00000402273 ; ENSG00000079841 . [Q86UR5-11 ]
    ENST00000425662 ; ENSP00000411235 ; ENSG00000079841 . [Q86UR5-10 ]
    ENST00000491071 ; ENSP00000430101 ; ENSG00000079841 . [Q86UR5-3 ]
    ENST00000517827 ; ENSP00000428367 ; ENSG00000079841 . [Q86UR5-9 ]
    ENST00000517960 ; ENSP00000429959 ; ENSG00000079841 . [Q86UR5-5 ]
    ENST00000518273 ; ENSP00000430408 ; ENSG00000079841 . [Q86UR5-6 ]
    ENST00000520567 ; ENSP00000430502 ; ENSG00000079841 . [Q86UR5-7 ]
    ENST00000521978 ; ENSP00000428417 ; ENSG00000079841 . [Q86UR5-1 ]
    ENST00000522291 ; ENSP00000430932 ; ENSG00000079841 . [Q86UR5-8 ]
    ENST00000523963 ; ENSP00000428328 ; ENSG00000079841 . [Q86UR5-13 ]
    GeneIDi 22999.
    KEGGi hsa:22999.
    UCSCi uc003pga.4. human. [Q86UR5-1 ]
    uc003pgb.4. human. [Q86UR5-2 ]
    uc003pgc.3. human. [Q86UR5-3 ]
    uc010kas.1. human. [Q86UR5-9 ]

    Organism-specific databases

    CTDi 22999.
    GeneCardsi GC06P072653.
    HGNCi HGNC:17282. RIMS1.
    HPAi HPA039297.
    MIMi 603649. phenotype.
    606629. gene.
    neXtProti NX_Q86UR5.
    Orphaneti 1872. Cone rod dystrophy.
    PharmGKBi PA38220.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286957.
    HOGENOMi HOG000082403.
    HOVERGENi HBG058147.
    InParanoidi Q86UR5.
    KOi K15291.
    OMAi ERKKTPG.
    OrthoDBi EOG7BGHJV.
    PhylomeDBi Q86UR5.
    TreeFami TF321703.

    Enzyme and pathway databases

    Reactomei REACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_15293. Dopamine Neurotransmitter Release Cycle.
    REACT_15309. Acetylcholine Neurotransmitter Release Cycle.
    REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
    REACT_15425. Serotonin Neurotransmitter Release Cycle.
    REACT_23947. GABA synthesis, release, reuptake and degradation.

    Miscellaneous databases

    ChiTaRSi RIMS1. human.
    EvolutionaryTracei Q86UR5.
    GeneWikii RIMS1.
    GenomeRNAii 22999.
    NextBioi 43896.
    PROi Q86UR5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UR5.
    Bgeei Q86UR5.
    Genevestigatori Q86UR5.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    2.60.40.150. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR001478. PDZ.
    IPR017455. Znf_FYVE-rel.
    IPR010911. Znf_FYVE-typ.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00168. C2. 2 hits.
    PF02318. FYVE_2. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 2 hits.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    SSF50156. SSF50156. 1 hit.
    SSF57903. SSF57903. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50916. RABBD. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7)."
      Johnson S., Halford S., Morris A.G., Patel R.J., Wilkie S.E., Hardcastle A.J., Moore A.T., Zhang K., Hunt D.M.
      Genomics 81:304-314(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT CORD7 HIS-820.
    2. "Identification of the alternative form of human RIM."
      Aoyama M., Asai K., Shishikura T., Ohira M., Inuzuka H., Morohashi A., Kato T., Nakagawara A.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
      Tissue: Neuroblastoma.
    3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 9; 10; 11; 12 AND 13).
      Tissue: Brain, Small intestine and Thalamus.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    7. "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin."
      Coppola T., Magnin-Luethi S., Perret-Menoud V., Gattesco S., Schiavo G., Regazzi R.
      J. Biol. Chem. 276:32756-32762(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 776-1692 (ISOFORMS 3; 4; 5; 6; 7 AND 8), MUTAGENESIS OF 796-LYS-LYS-797 AND 1591-ARG-ARG-1592, INTERACTION WITH SNAP25; SYT1 AND CACNA1B.
      Tissue: Brain.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1677; SER-1680; SER-1683 AND SER-1692, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Solution structure of the PDZ domain of human KIAA0340 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 585-694.

    Entry informationi

    Entry nameiRIMS1_HUMAN
    AccessioniPrimary (citable) accession number: Q86UR5
    Secondary accession number(s): A7MBN6
    , B7Z2M0, B7Z2Q9, B7Z3S3, B7Z6S2, E7EX08, E9PCB7, E9PCZ1, E9PF48, E9PHF5, E9PHR1, O15048, Q5JY21, Q5JY25, Q5SZK1, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3