Q86UR5 (RIMS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulating synaptic membrane exocytosis protein 1

Alternative name(s):
Rab-3-interacting molecule 1
Short name=RIM 1
Rab-3-interacting protein 2

Gene names

Name:	RIMS1
Synonyms:	KIAA0340, RAB3IP2, RIM1
ORF Names:	Nbla00761

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1692 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity By similarity.
Subunit structure	Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Binds UNC13A. Binds RIM binding proteins 1 and 2. Interacts with PPFIA3 and PPFIA4 By similarity. Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions. Ref.6
Subcellular location	Cell membrane; Peripheral membrane protein By similarity. Cell junction › synapse By similarity. Cell junction › synapse › presynaptic cell membrane; Peripheral membrane protein By similarity.
Tissue specificity	Detected in brain and retina.
Post-translational modification	Phosphorylated by BRSK1 By similarity. Ref.7 Ref.8 Ref.9 Ref.10
Involvement in disease	Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:603649]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Ref.1
Sequence similarities	Contains 2 C2 domains. Contains 1 FYVE-type zinc finger. Contains 1 PDZ (DHR) domain. Contains 1 RabBD (Rab-binding) domain.
Sequence caution	The sequence BAA20798.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI39600.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI42135.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Exocytosis Neurotransmitter transport Sensory transduction Transport Vision
Cellular component	Cell junction Cell membrane Membrane Synapse
Coding sequence diversity	Alternative splicing
Disease	Cone-rod dystrophy Disease mutation
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	calcium ion-dependent exocytosis Traceable author statement Ref.6. Source: UniProtKB cellular membrane fusion Non-traceable author statement Ref.6. Source: UniProtKB glutamate secretion Traceable author statement. Source: Reactome intracellular protein transport Inferred from electronic annotation. Source: InterPro protein complex assembly Inferred from direct assay Ref.6. Source: UniProtKB regulated secretory pathway Non-traceable author statement Ref.6. Source: UniProtKB response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle exocytosis Traceable author statement Ref.6. Source: UniProtKB visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome presynaptic membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	Rab GTPase binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW small GTPase regulator activity Traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	2	EBI-1043236,EBI-375543

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q86UR5-1)

Also known as: RIM1 alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86UR5-2)

Also known as: RIM short form;

The sequence of this isoform differs from the canonical sequence as follows:
     1040-1692: Missing.

Note: May be due to intron retention.

Isoform 3 (identifier: Q86UR5-3)

Also known as: RIM long form; Rab3 interacting protein variant 2;

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1102: Missing.
     1133-1245: Missing.
     1540-1573: Missing.

Isoform 4 (identifier: Q86UR5-4)

Also known as: Rab3 interacting protein variant 1;

The sequence of this isoform differs from the canonical sequence as follows:
     1065-1102: Missing.
     1133-1245: Missing.

Isoform 5 (identifier: Q86UR5-5)

Also known as: Rab3 interacting protein variant 3;

The sequence of this isoform differs from the canonical sequence as follows:
     924-924: Missing.
     1038-1244: Missing.
     1377-1385: Missing.

Isoform 6 (identifier: Q86UR5-6)

Also known as: Rab3 interacting protein variant 4;

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1102: Missing.
     1161-1245: Missing.
     1284-1455: Missing.

Isoform 7 (identifier: Q86UR5-7)

Also known as: Rab3 interacting protein variant 5;

The sequence of this isoform differs from the canonical sequence as follows:
     924-924: Missing.
     1039-1102: Missing.
     1133-1245: Missing.
     1284-1455: Missing.

Isoform 8 (identifier: Q86UR5-8)

Also known as: Rab3 interacting protein variant 6;

The sequence of this isoform differs from the canonical sequence as follows:
     924-924: Missing.
     1018-1245: Missing.
     1284-1455: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1692

1692

Regulating synaptic membrane exocytosis protein 1

PRO_0000190198

Regions

Domain

22 – 182

161

RabBD

Domain

605 – 691

87

PDZ

Domain

744 – 850

107

C2 1

Domain

1538 – 1640

103

C2 2

Zinc finger

110 – 170

61

FYVE-type

Compositional bias

1336 – 1402

67

Ser-rich

Amino acid modifications

Modified residue

324

1

Phosphoserine Ref.10

Modified residue

881

1

Phosphoserine By similarity

Modified residue

1252

1

Phosphoserine By similarity

Modified residue

1670

1

Phosphothreonine Ref.8

Modified residue

1677

1

Phosphoserine Ref.7 Ref.8 Ref.9

Modified residue

1679

1

Phosphoserine Ref.8

Modified residue

1680

1

Phosphoserine Ref.7 Ref.8 Ref.9

Modified residue

1683

1

Phosphoserine Ref.9

Modified residue

1692

1

Phosphoserine Ref.9

Natural variations

Alternative sequence

924

1

Missing in isoform 5, isoform 7 and isoform 8.

VSP_008161

Alternative sequence

1018 – 1245

228

Missing in isoform 8.

VSP_008162

Alternative sequence

1038 – 1244

207

Missing in isoform 5.

VSP_008163

Alternative sequence

1039 – 1102

64

Missing in isoform 3, isoform 6 and isoform 7.

VSP_008164

Alternative sequence

1040 – 1692

653

Missing in isoform 2.

VSP_008165

Alternative sequence

1065 – 1102

38

Missing in isoform 4.

VSP_008166

Alternative sequence

1133 – 1245

113

Missing in isoform 3, isoform 4 and isoform 7.

VSP_008167

Alternative sequence

1161 – 1245

85

Missing in isoform 6.

VSP_008168

Alternative sequence

1284 – 1455

172

Missing in isoform 6, isoform 7 and isoform 8.

VSP_008169

Alternative sequence

1377 – 1385

9

Missing in isoform 5.

VSP_008170

Alternative sequence

1540 – 1573

34

Missing in isoform 3.

VSP_008171

Natural variant

820

1

R → H in CORD7. Ref.1

VAR_016804

Experimental info

Mutagenesis

796 – 797

2

RR → AA: Abolishes interaction with SYT1 and CACNA1B. Ref.6

Mutagenesis

1591 – 1592

2

KK → AA: Abolishes interaction with SYT1 and CACNA1B. Ref.6

Sequence conflict

157

1

V → Y in CAI16961. Ref.4

Sequence conflict

484 – 494

11

Missing in BAB87121. Ref.2

Sequence conflict

484 – 494

11

Missing in BAB87242. Ref.2

Sequence conflict

484 – 494

11

Missing in BAA20798. Ref.3

Sequence conflict

484 – 494

11

Missing in AAI51854. Ref.5

Sequence conflict

484 – 494

11

Missing in AAI52436. Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1692

Helix Strand Turn

Details...

Beta strand

585 – 589

5

Beta strand

591 – 602

12

Beta strand

609 – 611

3

Beta strand

616 – 625

10

Beta strand

629 – 638

10

Helix

643 – 646

4

Beta strand

655 – 661

7

Helix

669 – 678

10

Helix

679 – 681

3

Beta strand

685 – 691

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (RIM1 alpha) [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0A96642DC832C15E	FASTA	1,692	189,073
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 1040 1050 1060 1070 1080 LMLPRAKRGR SAECLHTTRH LVRHYKTLPP KMPLLQSSSH WNIYSSILPA HTKTKSVTRQ 1090 1100 1110 1120 1130 1140 DISLHHECFN STVLRFTDEI LVSELQPFLD RARSASTNCL RPDTSLHSPE RERGRWSPSL 1150 1160 1170 1180 1190 1200 DRRRPPSPRI QIQHASPEND RHSRKSERSS IQKQTRKGTA SDAERVLPTC LSRRGHAAPR 1210 1220 1230 1240 1250 1260 ATDQPVIRGK HPARSRSSEH SSIRTLCSMH HLVPGGSAPP SPLLTRMHRQ RSPTQSPPAD 1270 1280 1290 1300 1310 1320 TSFSSRRGRQ LPQVPVRSGS IEQASLVVEE RTRQMKMKVH RFKQTTGSGS SQELDREQYS 1330 1340 1350 1360 1370 1380 KYNIHKDQYR SCDNVSAKSS DSDVSDVSAI SRTSSASRLS STSFMSEQSE RPRGRISSFT 1390 1400 1410 1420 1430 1440 PKMQGRRMGT SGRSIMKSTS VSGEMYTLEH NDGSQSDTAV GTVGAGGKKR RSSLSAKVVA 1450 1460 1470 1480 1490 1500 IVSRRSRSTS QLSQTESGHK KLKSTIQRST ETGMAAEMRK MVRQPSREST DGSINSYSSE 1510 1520 1530 1540 1550 1560 GNLIFPGVRL GADSQFSDFL DGLGPAQLVG RQTLATPAMG DIQIGMEDKK GQLEVEVIRA 1570 1580 1590 1600 1610 1620 RSLTQKPGSK STPAPYVKVY LLENGACIAK KKTRIARKTL DPLYQQSLVF DESPQGKVLQ 1630 1640 1650 1660 1670 1680 VIVWGDYGRM DHKCFMGVAQ ILLEELDLSS MVIGWYKLFP PSSLVDPTLT PLTRRASQSS 1690 LESSTGPPCI RS
	Isoform 2 (RIM short form) [UniParc]. Checksum: EF56FBC20E5A629E	FASTA	1,039	116,704
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 LMLPRAKRGR SAECLHTTR
	Isoform 3 (RIM long form) (Rab3 interacting protein variant 2) [UniParc]. Checksum: F34E4B8FAF1D35FD	FASTA	1,481	165,360
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 1040 1050 1060 1070 1080 LMLPRAKRGR SAECLHTTSE LQPFLDRARS ASTNCLRPDT SLHSPERERM HRQRSPTQSP 1090 1100 1110 1120 1130 1140 PADTSFSSRR GRQLPQVPVR SGSIEQASLV VEERTRQMKM KVHRFKQTTG SGSSQELDRE 1150 1160 1170 1180 1190 1200 QYSKYNIHKD QYRSCDNVSA KSSDSDVSDV SAISRTSSAS RLSSTSFMSE QSERPRGRIS 1210 1220 1230 1240 1250 1260 SFTPKMQGRR MGTSGRSIMK STSVSGEMYT LEHNDGSQSD TAVGTVGAGG KKRRSSLSAK 1270 1280 1290 1300 1310 1320 VVAIVSRRSR STSQLSQTES GHKKLKSTIQ RSTETGMAAE MRKMVRQPSR ESTDGSINSY 1330 1340 1350 1360 1370 1380 SSEGNLIFPG VRLGADSQFS DFLDGLGPAQ LVGRQTLATP AMAPYVKVYL LENGACIAKK 1390 1400 1410 1420 1430 1440 KTRIARKTLD PLYQQSLVFD ESPQGKVLQV IVWGDYGRMD HKCFMGVAQI LLEELDLSSM 1450 1460 1470 1480 VIGWYKLFPP SSLVDPTLTP LTRRASQSSL ESSTGPPCIR S
	Isoform 4 (Rab3 interacting protein variant 1) [UniParc]. Checksum: 98A7006DC8206CB3	FASTA	1,541	172,224
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 1040 1050 1060 1070 1080 LMLPRAKRGR SAECLHTTRH LVRHYKTLPP KMPLLQSSSH WNIYSELQPF LDRARSASTN 1090 1100 1110 1120 1130 1140 CLRPDTSLHS PERERMHRQR SPTQSPPADT SFSSRRGRQL PQVPVRSGSI EQASLVVEER 1150 1160 1170 1180 1190 1200 TRQMKMKVHR FKQTTGSGSS QELDREQYSK YNIHKDQYRS CDNVSAKSSD SDVSDVSAIS 1210 1220 1230 1240 1250 1260 RTSSASRLSS TSFMSEQSER PRGRISSFTP KMQGRRMGTS GRSIMKSTSV SGEMYTLEHN 1270 1280 1290 1300 1310 1320 DGSQSDTAVG TVGAGGKKRR SSLSAKVVAI VSRRSRSTSQ LSQTESGHKK LKSTIQRSTE 1330 1340 1350 1360 1370 1380 TGMAAEMRKM VRQPSRESTD GSINSYSSEG NLIFPGVRLG ADSQFSDFLD GLGPAQLVGR 1390 1400 1410 1420 1430 1440 QTLATPAMGD IQIGMEDKKG QLEVEVIRAR SLTQKPGSKS TPAPYVKVYL LENGACIAKK 1450 1460 1470 1480 1490 1500 KTRIARKTLD PLYQQSLVFD ESPQGKVLQV IVWGDYGRMD HKCFMGVAQI LLEELDLSSM 1510 1520 1530 1540 VIGWYKLFPP SSLVDPTLTP LTRRASQSSL ESSTGPPCIR S
	Isoform 5 (Rab3 interacting protein variant 3) [UniParc]. Checksum: 8192B1AF38A1661B	FASTA	1,475	164,580
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPGYRSSAR ESKSTTLTVP EQQRTTHHRS RSVSPHRGND 970 980 990 1000 1010 1020 QGKPRSRLPN VPLQRSLDEI HPTRRSRSPT RHHDASRSPV DHRTRDVDSQ YLSEQDSELL 1030 1040 1050 1060 1070 1080 MLPRAKRGRS AECLHTTRMH RQRSPTQSPP ADTSFSSRRG RQLPQVPVRS GSIEQASLVV 1090 1100 1110 1120 1130 1140 EERTRQMKMK VHRFKQTTGS GSSQELDREQ YSKYNIHKDQ YRSCDNVSAK SSDSDVSDVS 1150 1160 1170 1180 1190 1200 AISRTSSASR LSSTSFMSEQ SERPRGRIRR MGTSGRSIMK STSVSGEMYT LEHNDGSQSD 1210 1220 1230 1240 1250 1260 TAVGTVGAGG KKRRSSLSAK VVAIVSRRSR STSQLSQTES GHKKLKSTIQ RSTETGMAAE 1270 1280 1290 1300 1310 1320 MRKMVRQPSR ESTDGSINSY SSEGNLIFPG VRLGADSQFS DFLDGLGPAQ LVGRQTLATP 1330 1340 1350 1360 1370 1380 AMGDIQIGME DKKGQLEVEV IRARSLTQKP GSKSTPAPYV KVYLLENGAC IAKKKTRIAR 1390 1400 1410 1420 1430 1440 KTLDPLYQQS LVFDESPQGK VLQVIVWGDY GRMDHKCFMG VAQILLEELD LSSMVIGWYK 1450 1460 1470 LFPPSSLVDP TLTPLTRRAS QSSLESSTGP PCIRS
	Isoform 6 (Rab3 interacting protein variant 4) [UniParc]. Checksum: 815C71ECFEF6D8C5	FASTA	1,371	153,500
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 970 980 990 1000 1010 1020 DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1030 1040 1050 1060 1070 1080 LMLPRAKRGR SAECLHTTSE LQPFLDRARS ASTNCLRPDT SLHSPERERG RWSPSLDRRR 1090 1100 1110 1120 1130 1140 PPSPRIQIQH ASPENDRMHR QRSPTQSPPA DTSFSSRRGR QLPQVPVRSG SIEQESGHKK 1150 1160 1170 1180 1190 1200 LKSTIQRSTE TGMAAEMRKM VRQPSRESTD GSINSYSSEG NLIFPGVRLG ADSQFSDFLD 1210 1220 1230 1240 1250 1260 GLGPAQLVGR QTLATPAMGD IQIGMEDKKG QLEVEVIRAR SLTQKPGSKS TPAPYVKVYL 1270 1280 1290 1300 1310 1320 LENGACIAKK KTRIARKTLD PLYQQSLVFD ESPQGKVLQV IVWGDYGRMD HKCFMGVAQI 1330 1340 1350 1360 1370 LLEELDLSSM VIGWYKLFPP SSLVDPTLTP LTRRASQSSL ESSTGPPCIR S
	Isoform 7 (Rab3 interacting protein variant 5) [UniParc]. Checksum: 87E88E425651F382	FASTA	1,342	150,109
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPGYRSSAR ESKSTTLTVP EQQRTTHHRS RSVSPHRGND 970 980 990 1000 1010 1020 QGKPRSRLPN VPLQRSLDEI HPTRRSRSPT RHHDASRSPV DHRTRDVDSQ YLSEQDSELL 1030 1040 1050 1060 1070 1080 MLPRAKRGRS AECLHTTSEL QPFLDRARSA STNCLRPDTS LHSPERERMH RQRSPTQSPP 1090 1100 1110 1120 1130 1140 ADTSFSSRRG RQLPQVPVRS GSIEQESGHK KLKSTIQRST ETGMAAEMRK MVRQPSREST 1150 1160 1170 1180 1190 1200 DGSINSYSSE GNLIFPGVRL GADSQFSDFL DGLGPAQLVG RQTLATPAMG DIQIGMEDKK 1210 1220 1230 1240 1250 1260 GQLEVEVIRA RSLTQKPGSK STPAPYVKVY LLENGACIAK KKTRIARKTL DPLYQQSLVF 1270 1280 1290 1300 1310 1320 DESPQGKVLQ VIVWGDYGRM DHKCFMGVAQ ILLEELDLSS MVIGWYKLFP PSSLVDPTLT 1330 1340 PLTRRASQSS LESSTGPPCI RS
	Isoform 8 (Rab3 interacting protein variant 6) [UniParc]. Checksum: 8D52C8AD83A640AD	FASTA	1,291	144,361
	10 20 30 40 50 60 MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 70 80 90 100 110 120 MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 130 140 150 160 170 180 KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 190 200 210 220 230 240 GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 250 260 270 280 290 300 RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 310 320 330 340 350 360 VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 370 380 390 400 410 420 LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 430 440 450 460 470 480 PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 490 500 510 520 530 540 AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 550 560 570 580 590 600 PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 610 620 630 640 650 660 ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 670 680 690 700 710 720 GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 730 740 750 760 770 780 RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 790 800 810 820 830 840 YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 850 860 870 880 890 900 EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 910 920 930 940 950 960 SQRISDSDIS DYEVDDGIGV VPPGYRSSAR ESKSTTLTVP EQQRTTHHRS RSVSPHRGND 970 980 990 1000 1010 1020 QGKPRSRLPN VPLQRSLDEI HPTRRSRSPT RHHDASRSPV DHRTRDVDSQ YLSEQDRMHR 1030 1040 1050 1060 1070 1080 QRSPTQSPPA DTSFSSRRGR QLPQVPVRSG SIEQESGHKK LKSTIQRSTE TGMAAEMRKM 1090 1100 1110 1120 1130 1140 VRQPSRESTD GSINSYSSEG NLIFPGVRLG ADSQFSDFLD GLGPAQLVGR QTLATPAMGD 1150 1160 1170 1180 1190 1200 IQIGMEDKKG QLEVEVIRAR SLTQKPGSKS TPAPYVKVYL LENGACIAKK KTRIARKTLD 1210 1220 1230 1240 1250 1260 PLYQQSLVFD ESPQGKVLQV IVWGDYGRMD HKCFMGVAQI LLEELDLSSM VIGWYKLFPP 1270 1280 1290 SSLVDPTLTP LTRRASQSSL ESSTGPPCIR S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7)." Johnson S., Halford S., Morris A.G., Patel R.J., Wilkie S.E., Hardcastle A.J., Moore A.T., Zhang K., Hunt D.M. Genomics 81:304-314(2003) [PubMed: 12659814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT CORD7 HIS-820.
[2]	"Identification of the alternative form of human RIM." Aoyama M., Asai K., Shishikura T., Ohira M., Inuzuka H., Morohashi A., Kato T., Nakagawara A. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3). Tissue: Neuroblastoma.
[3]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]	"Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin." Coppola T., Magnin-Luethi S., Perret-Menoud V., Gattesco S., Schiavo G., Regazzi R. J. Biol. Chem. 276:32756-32762(2001) [PubMed: 11438518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 776-1692 (ISOFORMS 3; 4; 5; 6; 7 AND 8), MUTAGENESIS OF 796-LYS-LYS-797 AND 1591-ARG-ARG-1592, INTERACTION WITH SNAP25; SYT1 AND CACNA1B. Tissue: Brain.
[7]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1677 AND SER-1680, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1670; SER-1677; SER-1679 AND SER-1680, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1677; SER-1680; SER-1683 AND SER-1692, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[11]	"Solution structure of the PDZ domain of human KIAA0340 protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 585-694.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY190519 mRNA. Translation: AAO38848.1.
AB045726 mRNA. Translation: BAB87121.1.
AB051866 mRNA. Translation: BAB87242.1.
AB002338 mRNA. Translation: BAA20798.1. Different initiation.
AL160405 Genomic DNA. No translation available.
AL590011 , AL034373, AL390056, AL445256 Genomic DNA. Translation: CAI16961.1.
AL034373 , AL390056, AL445256, AL590011 Genomic DNA. Translation: CAI20558.1.
AL390056 , AL034373, AL445256, AL590011 Genomic DNA. Translation: CAI21554.1.
AL445256 , AL034373, AL390056, AL590011 Genomic DNA. Translation: CAI39598.1.
AL445256, AL035633 Genomic DNA. Translation: CAI39600.1. Sequence problems.
AL035633, AL445256 Genomic DNA. Translation: CAI42135.1. Sequence problems.
BC151853 mRNA. Translation: AAI51854.1.
BC152435 mRNA. Translation: AAI52436.1.
AF263305 mRNA. Translation: AAG23162.1.
AF263306 mRNA. Translation: AAG23163.1.
AF263307 mRNA. Translation: AAG23164.1.
AF263308 mRNA. Translation: AAG23165.1.
AF263309 mRNA. Translation: AAG23166.1.
AF263310 mRNA. Translation: AAG23167.1.

IPI

IPI00339392.
IPI00339394.
IPI00339396.
IPI00387015.
IPI00387018.
IPI00387019.
IPI00472331.
IPI00848003.

RefSeq

NP_055804.2. NM_014989.4.

UniGene

Hs.485729.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CSS	NMR	-	A	585-692	[»]

ProteinModelPortal

Q86UR5.

SMR

Q86UR5. Positions 27-188, 583-691, 745-871, 1524-1671.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q86UR5. 5 interactions.

MINT

MINT-2808819.

STRING

Q86UR5.

PTM databases

PhosphoSite

Q86UR5.

Polymorphism databases

DMDM

34395763.

Proteomic databases

PRIDE

Q86UR5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000264839; ENSP00000264839; ENSG00000079841.

GeneID

22999.

KEGG

hsa:22999.

UCSC

uc003pga.1. human.

Organism-specific databases

CTD

22999.

GeneCards

GC06P072653.

H-InvDB

HIX0006004.

HGNC

HGNC:17282. RIMS1.

HPA

HPA039297.

MIM

603649. phenotype.
606629. gene.

neXtProt

NX_Q86UR5.

Orphanet

1872. Cone rod dystrophy.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG15507.

GeneTree

ENSGT00550000074588.

HOVERGEN

HBG058147.

InParanoid

Q86UR5.

OMA

CLSRRGY.

PhylomeDB

Q86UR5.

Enzyme and pathway databases

Pathway_Interaction_DB

botulinumtoxinpathway. Effects of Botulinum toxin.

Reactome

REACT_13685. Neuronal System.

Gene expression databases

ArrayExpress

Q86UR5.

Bgee

Q86UR5.

Genevestigator

Q86UR5.

GermOnline

ENSG00000079841. Homo sapiens.

Family and domain databases

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR001478. PDZ/DHR/GLGF.
IPR010911. Rab-bd_domain.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Gene3D

G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.

KO

K15291.

Pfam

PF00168. C2. 2 hits.
PF00595. PDZ. 1 hit.
[Graphical view]

SMART

SM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 2 hits.
SSF57903. FYVE_PHD_ZnF. 1 hit.
SSF50156. PDZ. 1 hit.

PROSITE

PS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

43896.

SOURCE

Search...

Entry information

Entry name

RIMS1_HUMAN

Accession

Primary (citable) accession number: Q86UR5
Secondary accession number(s): A7MBN6 , O15048, Q5JY25, Q5SZK1, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.