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Protein

LHFPL tetraspan subfamily member 3 protein

Gene

LHFPL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LHFPL tetraspan subfamily member 3 proteinImported
Alternative name(s):
Lipoma HMGIC fusion partner-like 3 proteinImported
Gene namesi
Name:LHFPL3Imported
Synonyms:LHFPL4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000187416.11.
HGNCiHGNC:6589. LHFPL3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi375612.
PharmGKBiPA30361.

Polymorphism and mutation databases

DMDMi109892510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002447661 – 236LHFPL tetraspan subfamily member 3 proteinAdd BLAST236

Proteomic databases

PaxDbiQ86UP9.
PeptideAtlasiQ86UP9.
PRIDEiQ86UP9.

PTM databases

iPTMnetiQ86UP9.
PhosphoSitePlusiQ86UP9.

Expressioni

Gene expression databases

BgeeiENSG00000187416.
CleanExiHS_LHFPL3.
HS_LHFPL4.
ExpressionAtlasiQ86UP9. baseline and differential.
GenevisibleiQ86UP9. HS.

Organism-specific databases

HPAiHPA069691.

Interactioni

Protein-protein interaction databases

IntActiQ86UP9. 1 interactor.
STRINGi9606.ENSP00000444350.

Structurei

3D structure databases

ProteinModelPortaliQ86UP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
HOGENOMiHOG000294163.
HOVERGENiHBG056723.
InParanoidiQ86UP9.
OrthoDBiEOG091G0H85.

Family and domain databases

InterProiView protein in InterPro
IPR019372. Lipome_HGMIC_fus_partner-like.
PfamiView protein in Pfam
PF10242. L_HMGIC_fpl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86UP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAAAAAAA AAAAMLPAQE AAKLYHTNYV RNSRAIGVLW AIFTICFAIV
60 70 80 90 100
NVVCFIQPYW IGDGVDTPQA GYFGLFHYCI GNGFSRELTC RGSFTDFSTL
110 120 130 140 150
PSGAFKAASF FIGLSMMLII ACIICFTLFF FCNTATVYKI CAWMQLTSAA
160 170 180 190 200
CLVLGCMIFP DGWDSDEVKR MCGEKTDKYT LGACSVRWAY ILAIIGILDA
210 220 230
LILSFLAFVL GNRQDSLMAE ELKAENKVLL SQYSLE
Length:236
Mass (Da):25,769
Last modified:March 19, 2014 - v3
Checksum:i6066467C92D6FFF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18A → T in AAI29938 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260763 mRNA. Translation: AAP14954.1.
AK299759 mRNA. Translation: BAG61648.1.
CH236947 Genomic DNA. Translation: EAL24407.1.
BC129937 mRNA. Translation: AAI29938.1.
RefSeqiNP_945351.1. NM_199000.2.
UniGeneiHs.659164.

Genome annotation databases

EnsembliENST00000424859; ENSP00000393128; ENSG00000187416.
GeneIDi375612.
KEGGihsa:375612.
UCSCiuc064gsi.1. human.

Similar proteinsi

Entry informationi

Entry nameiLHPL3_HUMAN
AccessioniPrimary (citable) accession number: Q86UP9
Secondary accession number(s): A1L383, A4D0Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 19, 2014
Last modified: October 25, 2017
This is version 78 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families