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Protein

CUB and zona pellucida-like domain-containing protein 1

Gene

CUZD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.By similarity1 Publication

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cell proliferation Source: UniProtKB
  • substrate-dependent cell migration, cell attachment to substrate Source: UniProtKB
  • trypsinogen activation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
CUB and zona pellucida-like domain-containing protein 1
Short name:
CUB and ZP domain-containing protein 1
Alternative name(s):
Transmembrane protein UO-44
Gene namesi
Name:CUZD1Imported
ORF Names:UNQ224/PRO257
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17937. CUZD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 568544ExtracellularSequence analysisAdd
BLAST
Transmembranei569 – 58921HelicalSequence analysisAdd
BLAST
Topological domaini590 – 60718CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • transport vesicle membrane Source: UniProtKB-SubCell
  • zymogen granule membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903546.

Polymorphism and mutation databases

BioMutaiCUZD1.
DMDMi74750426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 607583CUB and zona pellucida-like domain-containing protein 1Sequence analysisPRO_0000233331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi17 ↔ 58PROSITE-ProRule annotation
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Disulfide bondi85 ↔ 107PROSITE-ProRule annotation
Disulfide bondi154 ↔ 180PROSITE-ProRule annotation
Disulfide bondi207 ↔ 229PROSITE-ProRule annotation
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence analysis
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi442 ↔ 498PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ86UP6.
PaxDbiQ86UP6.
PeptideAtlasiQ86UP6.
PRIDEiQ86UP6.

PTM databases

iPTMnetiQ86UP6.
PhosphoSiteiQ86UP6.

Expressioni

Tissue specificityi

Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue.1 Publication

Gene expression databases

BgeeiQ86UP6.
CleanExiHS_CUZD1.
ExpressionAtlasiQ86UP6. baseline and differential.
GenevisibleiQ86UP6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357900.

Structurei

3D structure databases

ProteinModelPortaliQ86UP6.
SMRiQ86UP6. Positions 58-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 146122CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini154 – 265112CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini276 – 519244ZPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
GeneTreeiENSGT00840000129876.
HOVERGENiHBG081378.
InParanoidiQ86UP6.
OMAiIIVKCEM.
OrthoDBiEOG71CFMK.
PhylomeDBiQ86UP6.
TreeFamiTF351216.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00042. CUB. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
PROSITEiPS01180. CUB. 2 hits.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q86UP6-1) [UniParc]FASTAAdd to basket

Also known as: UO-44D1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELVRRLMPL TLLILSCLAE LTMAEAEGNA SCTVSLGGAN MAETHKAMIL
60 70 80 90 100
QLNPSENCTW TIERPENKSI RIIFSYVQLD PDGSCESENI KVFDGTSSNG
110 120 130 140 150
PLLGQVCSKN DYVPVFESSS STLTFQIVTD SARIQRTVFV FYYFFSPNIS
160 170 180 190 200
IPNCGGYLDT LEGSFTSPNY PKPHPELAYC VWHIQVEKDY KIKLNFKEIF
210 220 230 240 250
LEIDKQCKFD FLAIYDGPST NSGLIGQVCG RVTPTFESSS NSLTVVLSTD
260 270 280 290 300
YANSYRGFSA SYTSIYAENI NTTSLTCSSD RMRVIISKSY LEAFNSNGNN
310 320 330 340 350
LQLKDPTCRP KLSNVVEFSV PLNGCGTIRK VEDQSITYTN IITFSASSTS
360 370 380 390 400
EVITRQKQLQ IIVKCEMGHN STVEIIYITE DDVIQSQNAL GKYNTSMALF
410 420 430 440 450
ESNSFEKTIL ESPYYVDLNQ TLFVQVSLHT SDPNLVVFLD TCRASPTSDF
460 470 480 490 500
ASPTYDLIKS GCSRDETCKV YPLFGHYGRF QFNAFKFLRS MSSVYLQCKV
510 520 530 540 550
LICDSSDHQS RCNQGCVSRS KRDISSYKWK TDSIIGPIRL KRDRSASGNS
560 570 580 590 600
GFQHETHAEE TPNQPFNSVH LFSFMVLALN VVTVATITVR HFVNQRADYK

YQKLQNY
Length:607
Mass (Da):68,153
Last modified:June 1, 2003 - v1
Checksum:i098A365612251C5E
GO
Isoform 21 Publication (identifier: Q86UP6-2) [UniParc]FASTAAdd to basket

Also known as: UO-44B1 Publication

, UO-44C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.

Show »
Length:326
Mass (Da):36,978
Checksum:iAE3B82BB66C99920
GO
Isoform 31 Publication (identifier: Q86UP6-3) [UniParc]FASTAAdd to basket

Also known as: UO-44A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-366: Missing.

Show »
Length:241
Mass (Da):27,486
Checksum:iBE6169197516A767
GO

Sequence cautioni

The sequence AAG23215.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351T → P in CAD98079 (PubMed:17974005).Curated
Sequence conflicti331 – 3311V → A in CAD98079 (PubMed:17974005).Curated
Sequence conflicti494 – 4952VY → AC in AAG23215 (PubMed:15184879).Curated
Sequence conflicti560 – 5601E → G in CAD98080 (PubMed:17974005).Curated
Sequence conflicti583 – 5831T → I in CAD98080 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561G → S.
Corresponds to variant rs35120257 [ dbSNP | Ensembl ].
VAR_061992

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 366366Missing in isoform 3. 1 PublicationVSP_052018Add
BLAST
Alternative sequencei1 – 281281Missing in isoform 2. 2 PublicationsVSP_052019Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260047 mRNA. Translation: AAP15458.1.
AY260048 mRNA. Translation: AAP15459.1.
AY260049 mRNA. Translation: AAP15460.1.
AY260050 mRNA. Translation: AAP15461.1.
AF305835 mRNA. Translation: AAG23215.1. Frameshift.
AY358556 mRNA. Translation: AAQ88920.1.
AK289445 mRNA. Translation: BAF82134.1.
AL359747 Genomic DNA. Translation: CAH70003.1.
AL359747 Genomic DNA. Translation: CAH70004.1.
AL359747, AC073585 Genomic DNA. Translation: CAH70006.1.
CH471066 Genomic DNA. Translation: EAW49302.1.
CH471066 Genomic DNA. Translation: EAW49303.1.
CH471066 Genomic DNA. Translation: EAW49304.1.
CH471066 Genomic DNA. Translation: EAW49305.1.
BC136755 mRNA. Translation: AAI36756.1.
BX538283 mRNA. Translation: CAD98079.2.
BX538284 mRNA. Translation: CAD98080.2.
CCDSiCCDS7631.1. [Q86UP6-1]
RefSeqiNP_071317.2. NM_022034.5. [Q86UP6-1]
UniGeneiHs.647182.

Genome annotation databases

EnsembliENST00000368904; ENSP00000357900; ENSG00000138161. [Q86UP6-1]
ENST00000392790; ENSP00000376540; ENSG00000138161. [Q86UP6-1]
GeneIDi50624.
KEGGihsa:50624.
UCSCiuc001lgs.4. human. [Q86UP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260047 mRNA. Translation: AAP15458.1.
AY260048 mRNA. Translation: AAP15459.1.
AY260049 mRNA. Translation: AAP15460.1.
AY260050 mRNA. Translation: AAP15461.1.
AF305835 mRNA. Translation: AAG23215.1. Frameshift.
AY358556 mRNA. Translation: AAQ88920.1.
AK289445 mRNA. Translation: BAF82134.1.
AL359747 Genomic DNA. Translation: CAH70003.1.
AL359747 Genomic DNA. Translation: CAH70004.1.
AL359747, AC073585 Genomic DNA. Translation: CAH70006.1.
CH471066 Genomic DNA. Translation: EAW49302.1.
CH471066 Genomic DNA. Translation: EAW49303.1.
CH471066 Genomic DNA. Translation: EAW49304.1.
CH471066 Genomic DNA. Translation: EAW49305.1.
BC136755 mRNA. Translation: AAI36756.1.
BX538283 mRNA. Translation: CAD98079.2.
BX538284 mRNA. Translation: CAD98080.2.
CCDSiCCDS7631.1. [Q86UP6-1]
RefSeqiNP_071317.2. NM_022034.5. [Q86UP6-1]
UniGeneiHs.647182.

3D structure databases

ProteinModelPortaliQ86UP6.
SMRiQ86UP6. Positions 58-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357900.

PTM databases

iPTMnetiQ86UP6.
PhosphoSiteiQ86UP6.

Polymorphism and mutation databases

BioMutaiCUZD1.
DMDMi74750426.

Proteomic databases

EPDiQ86UP6.
PaxDbiQ86UP6.
PeptideAtlasiQ86UP6.
PRIDEiQ86UP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368904; ENSP00000357900; ENSG00000138161. [Q86UP6-1]
ENST00000392790; ENSP00000376540; ENSG00000138161. [Q86UP6-1]
GeneIDi50624.
KEGGihsa:50624.
UCSCiuc001lgs.4. human. [Q86UP6-1]

Organism-specific databases

CTDi50624.
GeneCardsiCUZD1.
HGNCiHGNC:17937. CUZD1.
MIMi616644. gene.
neXtProtiNX_Q86UP6.
PharmGKBiPA134903546.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
GeneTreeiENSGT00840000129876.
HOVERGENiHBG081378.
InParanoidiQ86UP6.
OMAiIIVKCEM.
OrthoDBiEOG71CFMK.
PhylomeDBiQ86UP6.
TreeFamiTF351216.

Miscellaneous databases

ChiTaRSiCUZD1. human.
GeneWikiiCUZD1.
GenomeRNAii50624.
PROiQ86UP6.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UP6.
CleanExiHS_CUZD1.
ExpressionAtlasiQ86UP6. baseline and differential.
GenevisibleiQ86UP6. HS.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00042. CUB. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
PROSITEiPS01180. CUB. 2 hits.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44."
    Leong C.T.C., Ng C.Y., Ng C.P., Ma Z.S., Nguyen T.H., Tay S.K., Huynh H.
    Oncogene 23:5707-5718(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Urinary bladder.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-607 (ISOFORM 1).

Entry informationi

Entry nameiCUZD1_HUMAN
AccessioniPrimary (citable) accession number: Q86UP6
Secondary accession number(s): A8K080
, B2RN93, D3DRE5, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.